<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJ80</accession>
    <name>A0A367IJ80_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005711">
        <property type="protein sequence ID" value="RCH77725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJ80"/>
    <dbReference type="OrthoDB" id="2290007at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="128" mass="15062" checksum="EAE5DA4A78EB643C" modified="2018-11-07" version="1" fragment="single">IPFVHARHDHVHLWSLELCAKKLYALKKVFKFKIPGDKSDVKNILAMGHFVWQLKKQLEQAHYVVQQMKQEHDDNEINRIMDDGDIEIESLKSWINLEIKKPVKGAEYGLLLPVEKNGDEENLRFVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJM9</accession>
    <name>A0A367IJM9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005583">
        <property type="protein sequence ID" value="RCH77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJM9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17367" checksum="663C43B121D34BB1" modified="2018-11-07" version="1" fragment="single">KLSSFHFNYSQFSFLPNQIYFIMSAALRFTCPSCGYIAGSYRELTAHQNRSSCLYAIINDSSDESISDQPEATVLSPMNMDTDIEYPSAADDSDTTINPIIYEHTTQESQLSIIQQFAVAFYKIADESSVSREAERQLGRCINTFLIQKLNQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK51</accession>
    <name>A0A367IK51_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005444">
        <property type="protein sequence ID" value="RCH78067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK51"/>
    <dbReference type="STRING" id="86630.A0A367IK51"/>
    <dbReference type="OrthoDB" id="2288457at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="17762" checksum="B6D10AE2A9BF8C32" modified="2018-11-07" version="1" fragment="single">SDVLYCPMKTVKSNKLPPLLVEVQCTANMAFFRRLMEYSLSINKHYHALPVVLAICIHNTTSDLMELSTPSRTLPFLVELPCVGWAKSCYLMNGGSIAKHLQEIPLDLFVAVGYFLIEQKPSLADMIHRDDKTIIMLYELAKKVFGDQIQVEQGAANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKX1</accession>
    <name>A0A367IKX1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005251">
        <property type="protein sequence ID" value="RCH78332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKX1"/>
    <dbReference type="STRING" id="86630.A0A367IKX1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="118" mass="13112" checksum="541723BF86CA6FB0" modified="2018-11-07" version="1" fragment="single">RPLPKALNIIRPAPPPFPNQHDSLSSSTASSPSEISTISNFSTFSNSRPQPTIFNPASLFQSNINTFKSPASTVGINPQRFYQRPRSNSNLSRSTFFSAFSDHHNNTNTDNEEEDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL20</accession>
    <name>A0A367IL20_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005336">
        <property type="protein sequence ID" value="RCH78221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL20"/>
    <dbReference type="OrthoDB" id="10413411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016605020" evidence="2">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH78221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="118" mass="12967" checksum="358362749B94FC0E" modified="2018-11-07" version="1">MQIKLVILTICASLAAIGFATPSPQADGLDSITLSDEQTPPGFAIDDLDSLGGIDEDIGDPILGNLDEALVRRRIPGGIRRIMRLRGGRRGRGRGGRRRRGRIGRRIRKAQRELKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INZ2</accession>
    <name>A0A367INZ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004527">
        <property type="protein sequence ID" value="RCH79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INZ2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9605" checksum="AF94D543EF3D7A52" modified="2018-11-07" version="1" fragment="single">STPRRSAQYFYRTGKCNKRREKRSQSLPKLCRPGKNLEGRQAIAGVRLLFLNENEEQEGTSSSESVLEMGEGWENDAWRLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPC5</accession>
    <name>A0A367IPC5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metaxin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MTX1</name>
        <name evidence="8" type="ORF">CU097_000209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004429">
        <property type="protein sequence ID" value="RCH79544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPC5"/>
    <dbReference type="STRING" id="86630.A0A367IPC5"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH79544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11983" checksum="325637735D02370B" modified="2018-11-07" version="1" fragment="single">NELDKQQAKAFVTLVEQKLKPALLFSMWLEPPNANEITFKSYYGHLPQPINQIVFYKKQSQVTKSLLADRDILVREEIYQEAMKALEALSVKLGDNTYFFNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISN0</accession>
    <name>A0A367ISN0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MLH3_1</name>
        <name evidence="2" type="ORF">CU097_001956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003781">
        <property type="protein sequence ID" value="RCH80700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISN0"/>
    <dbReference type="STRING" id="86630.A0A367ISN0"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="1">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="30362" checksum="D416C5D2E236DF16" modified="2018-11-07" version="1">MTPLDSSQFGTFLSIPNRLSREDLKSAKVLGQVDRKFIAIKLDDKSILMMDQHAADERIKLESMMKSDIISRKTVILEPCIPFDLNSAAEYELMTSDRILEYLKIWGIHLVTTKTMPIASSASDDTIILSSSHYFSSTPNTKTYYRVYVTRLPELIADRCITNHALIKTIIRDYVYWIVEQHYNPAIVKTNCPKGMVDILKSKACRNAIMFNDPLSLEQCQDIVDNLSKSSFPFQCAHGRPSVIPLSLSLQPTVIQRTIHWDKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT62</accession>
    <name>A0A367IT62_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein SGT1 A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SGT1A</name>
        <name evidence="6" type="ORF">CU097_001292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003797">
        <property type="protein sequence ID" value="RCH80661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT62"/>
    <dbReference type="STRING" id="86630.A0A367IT62"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000012">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="158"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="4">
        <location>
            <begin position="260"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH80661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="346" mass="39024" checksum="488DFC107D787784" modified="2018-11-07" version="1" fragment="single">MNVTEQTKKSAEIYAKANDAFFDDDYDEALSLFSQLVDLEPENAEFILKRCSVYQKVNKLDLALKDVEKALDILKHGSRSLMARAHLQKGIILHRLERYKEAEEHLNQSKGLNPNEKTLTTWLRKNADKLKEVNQSSSNATINTTTPVPMESTNKPLNTTARHEWFQNDNFVTIEVFVKKVMAQDVSVGFYEDSLSLAAKLPNGSTYSIELDPLAHKIIPEESTYKVLSTKIEVKLKKKVPGIMWGALEGENDLGTPAPAVTNNKKQTKDWNKLIKEVDDEKLEGEAAVNALFQQIYRDADPDARRAMMKSFIESNGTCLSTNWSEVGSKKVETKPPEGTIVKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW06</accession>
    <name>A0A367IW06_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003246">
        <property type="protein sequence ID" value="RCH81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW06"/>
    <dbReference type="OrthoDB" id="10314047at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="238" mass="26642" checksum="E298643D49BC4EED" modified="2018-11-07" version="1">MSLTRFFQYQALEKLINLTCEKAERIFRGQVCPLILSYQLQTVVDRLAEEQVRILRDDLSWRTFPKKHKLVMADPSPVPTKRHRPNPSSAGAVSVVKKVASGRASTPLPCRFVLQRNRQDDSLRAALQRPSQFGGSRFGKRPVNDLLVLSISSCRKDPGITFSPGAFVSLCPPSVPACIPSAAEIRPSCLPALSSSVVFHCPQKRRHEEDVDDRNMAHSSSRPIKRRKTQSGHVSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWT9</accession>
    <name>A0A367IWT9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003157">
        <property type="protein sequence ID" value="RCH82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWT9"/>
    <dbReference type="OrthoDB" id="2291008at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="10237" checksum="646AF9657F786A3E" modified="2018-11-07" version="1" fragment="single">PTHKHHRSMPSLSFSISSTSHQSSPGTSIHHKRHSETISVKRWDDSQLEMDLAEDMDDKKQPLVSRMKYKLSRYRHEFKKMATWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXT5</accession>
    <name>A0A367IXT5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S14 cytosolic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SEC14_1</name>
        <name evidence="2" type="ORF">CU097_005170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002988">
        <property type="protein sequence ID" value="RCH82515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXT5"/>
    <dbReference type="STRING" id="86630.A0A367IXT5"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="98"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="325" mass="36979" checksum="DF3506CD7E4B5DF1" modified="2018-11-07" version="1">MLTPEQQRERINQLRDQIGQVDYPLTDEYLEQFLIARSWNVSGAKDQLVKTFEWRKSNGIDLHPVATRENKLPVLYAVRGYESIPDSNLEALPGVSESVLRINKYMGGTCLHKTDREGCPVYIERLGYHKAKEIAKNVKMEEVEWYHIACTEFLNRVIMKDCSKKAGRIINRETVIFDCTGMGWHQLHMPALNYIRAIAHCDQNYYPETLNKLFLINAPSAFVYVWKIAKTWLDPGTIAKIQILGSDYKDTLLKQIPPENLPSFLGGECTCEHMDGGCVPSQVLKNAKPLEARDDNEKVSTAYNTSIMNEAKTSAVVRGPSFYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYB7</accession>
    <name>A0A367IYB7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PHO85_1</name>
        <name evidence="17" type="ORF">CU097_006111</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002931">
        <property type="protein sequence ID" value="RCH82680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYB7"/>
    <dbReference type="STRING" id="86630.A0A367IYB7"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH82680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="313" mass="35756" checksum="515447F003975FBF" modified="2018-11-07" version="1">MATGYPPEQRYTRLEKLGEGTYATVYKGKNRATGEIVALKEIHLDPEEGAPSTAIREISLMKELKHPNIVRLQDIIHTENKLSLVFEYMDQDLKKYMDSTARATRGALDVSIIKSFMYQLLRGIAYCHENRVLHRDLKPQNLLINKHLQLKLGDFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRMYSTSIDIWSAGCIMAEMYTGRPLFPGSTNEDQLQKIFRLLGTPTEQTWPTISQFPEYKPPQVIYPAQHISQVLTTIDPIGIDLLSRMLQYQPQMRISAKDALEHAYFNEVRFLFENSAPTKVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZL0</accession>
    <name>A0A367IZL0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein PEP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VPS10_1</name>
        <name evidence="3" type="ORF">CU097_000437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002766">
        <property type="protein sequence ID" value="RCH83126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZL0"/>
    <dbReference type="STRING" id="86630.A0A367IZL0"/>
    <dbReference type="OrthoDB" id="2290808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sortilin N-terminal" evidence="2">
        <location>
            <begin position="396"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="701" mass="78942" checksum="CEA7AAA2D4B8E8F8" modified="2018-11-07" version="1" fragment="single">MCEMNGNVRGANEMLERGTKMTVRFDKAIQEQVKRSGQEKKKDDLIKIHSQTTGVFSATDYLIDGANDFTFSGTDNGLVNLSTSVPFTSQQFQLHIQLYNRYHVLQEPNVDIKDEKTAFLNLPQSKTINANEIDINCMHRKNRKHLEWLKKKTSQGKEASTLEAKLEKASFSASNNVEEFQQNYRIHEDCSKKLRSFYSSSNRASRLQSLEIQKKKYLNKITAQERKFLTKTNTGADKKQLLMFIRDRGRSRWKEQLHGKHVNVCITNGHMTSQTCIYCYQKLCHPKAMLTKKNKQVSQEIKGALMCVNPKFMAVKSGRSTKSRDALSSLAISLSGLTQCLIGSPLPPFAQSQTSQFNTDTFNKLLWSFVPARDYLTSTLCAHTIVVLWLDANSHTLYRSENQGKEWNQVEDIGKTATYLYEHPYDNDRAYVLSSGTTHWKTVDKGKTWQEFHTRSEPGSSSSHLSFHAERSGYILFSGVSCKFGSWLGIDCQTSISYTYDNFDTINPLRTHASSCIWSRSSAEFKSAPTSEIMCVQSASGKSTNGLSLPDDLQLVRSDDFFHTEKVVDFGLGREMTGVLAVSAVGRFIVAAVKPTSQTDMTLYVTHDGEHWHETIFPEGAALHEKSFTIIESSNPALLVDVLSGENAQFGSLYKSNSNGTFFSKSLENTNRNSMGYIDIERIPGVEGVLVANQILNPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J042</accession>
    <name>A0A367J042_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002706">
        <property type="protein sequence ID" value="RCH83308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J042"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="510"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="645" mass="72054" checksum="46930394DF305C93" modified="2018-11-07" version="1">MAAYNIPPPIPDRPPQEKIEVCNVTEGETVHQRFLLVNGRAGKRDGKFDLLIQVYCNDFPPTQWPCVDSYFKALVHLVPGPNTITFAFVNVTLHFHVNYLPLLQNPPLSLAIIIGSDSPATFDVPPEKEGQNTLDVAIRKLRMAGYMWQAFCAEQMYRNGMQRRTFRLDEDWLPDTTSCQENRVMRTTAKVHIIRSTKTVAEIRDIRRAQQRHDDQANSEDLESLFGICLNDLGRYSPFNQPCHVACMLLDAHWDPQRQAILGHAALGGGGGDIALGIFGSHSLHAWPSCIEDIVPCFMNDTRTDTRFIANDAGESGTWWKALNIGMGAMLHEVGHSYTLDHTPSGIMSRGFNNWNRTFMAKEPGHSPIPPEDEEGSHWHRVDVIRLRFHPAFRLPQDGPRGAINHSSPTIMPLEENCLRISVPAGLSMIVYSVNSHYRTHTEFLQHQPKNVTLSLSDIYKQLQCNPNDNIKLETISVNQQGQSIDSVATFFHTHIVQLPGLSSTVFKSPTFGGMEGGSKYLVPFISDAFKKQLVRIVIHHGDFLDGFILYWSDGTRDTVGCLGGRRSTYDVLPGESIQGLLVRCGAWIDGIQFKLSSGKTSPWYGGQGGSPVLIEPPSGYNLIGVHASSGNWMYQIGILYQKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0C4</accession>
    <name>A0A367J0C4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBC13_2</name>
        <name evidence="9" type="ORF">CU097_005376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01002675">
        <property type="protein sequence ID" value="RCH83398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0C4"/>
    <dbReference type="STRING" id="86630.A0A367J0C4"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH83398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="16755" checksum="6E65958C056C6E8C" modified="2018-11-07" version="1">MALPKRIVKETERLLADPAPGISATPHEENLRYFDVVIAGPSQSPFEGGVFRLELFLPEDYPMGPPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVASHWKEDEKGAIEQARQWTAMYAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0E4</accession>
    <name>A0A367J0E4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL4_1</name>
        <name evidence="5" type="ORF">CU097_001557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002744">
        <property type="protein sequence ID" value="RCH83191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0E4"/>
    <dbReference type="STRING" id="86630.A0A367J0E4"/>
    <dbReference type="OrthoDB" id="2245170at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH83191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="11217" checksum="F274CAE751B42072" modified="2018-11-07" version="1" fragment="single">MSAARPVINVYADSGKNVTSTVPLPAVFKAPIRPDIVNFVHTNMAKNKRQPHSVSAKAGEQTSAESWGTGRAVARIPRVNGSGTHRAGQAAFGNMCRGGRMFAPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J143</accession>
    <name>A0A367J143_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002601">
        <property type="protein sequence ID" value="RCH83630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J143"/>
    <dbReference type="STRING" id="86630.A0A367J143"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="514" mass="56644" checksum="3CA8DCBF31383AC7" modified="2018-11-07" version="1">MADSFCSSISEIVTQRIIQSSGFESATNQSIHVLSDVLRQYLELLGSYVSAYANLNGRTIGNAWDLIDAMEDLYITPDSLKEWLDKEGKQLSPCWAAQSDPSRLLEGTVRKGRHNFEDIIEYNFQSIPEFELCPESPPIEEPLSPTPTYSTTLPQYIPPFLPAFPEIKEDGVVEEENGPAIDKSLKEKAIQSMIPQVKAASAESLPPPLIVKNKKKPVDNPFTHIVPFEESILAAEANISQQPLSLAIEPADLSTKKMSTPEKEPPRKKARLPALKGLSNTNGAALKLGEGIVGHDELFRIQTENEAAPGNHMFDRDIGVFEEIVRSVTDPLLLPRLTTPNLLIDVATTGTTSVPATPTTQHTMNDQHSVPSSPQSSASNDITRPNKASMLAALASSKAGLKRLGRPLSPMSLSEFANAKASTGSVDINNMQKTGDSKYIIKKKKMLLQQQLLQQQQQLLLQQQQQQQQQQQQGQQGQQGQNQQIQLMQPSPSDSQVPQQDTQQNMDEIKEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1Q1</accession>
    <name>A0A367J1Q1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002534">
        <property type="protein sequence ID" value="RCH83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1Q1"/>
    <dbReference type="STRING" id="86630.A0A367J1Q1"/>
    <dbReference type="OrthoDB" id="2363016at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="562" mass="65292" checksum="D9FA7C71C7DA3707" modified="2018-11-07" version="1">MNSPCVQEQQPQKHFIPQAEDILTDEDLLELFRIIKLIVRKKPDTERIAKLYFCIVYALGDQYPFHKPAHGDHIIFRDEFMTGHVQLPFSAFCTCPERAESTQQQQQQQQKQLSVSYLTNPSSSLAPLPRLISKSEEIMTDRYSVRPYTHIRPNTTINNITTTATTTWSPEPIHSHRSSESSPGIDVVMEPKQRGFYYEDGRITREPPLLQRYAEQGVLTQASLLRKRKKHTPDLDYHELSVLPPKKPKIPHRHGEFKQRRKISLSLCLEWIGNEKGSDCMFIGDDIISRMRTVMITDLEQKAQRLPEDFSLAIEQVSLPDDLDADQLNADEAGRLLMPALMILTHHSNMKPHLDNGMNQNGIYYNNDYFRLYLAFVQFQNIFARLFPNEIIKIATPSSLEDEAESPVSERDKDRERNVNMKAYRVWIEPRLTETNWAAFRRNVMVGERMMQLTKVVGQGVLLMTKELSGSKLHLTFTNNEWDEFIQGLSQGKWDETIDWSHEDQEKMQGDSESRLVNELRYKFDTHFWFTDQGTLVSPAERRAARAQEKEKRLKKARNAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1Z2</accession>
    <name>A0A367J1Z2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALG2</name>
        <name evidence="15" type="ORF">CU097_003480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01002502">
        <property type="protein sequence ID" value="RCH83958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1Z2"/>
    <dbReference type="STRING" id="86630.A0A367J1Z2"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="211"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH83958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="452" mass="51755" checksum="29A2D9DEA36D0F02" modified="2018-11-07" version="1">MDAKLNIAFIHPDLGIGGAERLVVDAAAGIQSKGHQVVMYTSHHDPNHCFEETRDGTLSVRVFGDFLPREIFGKFYIICAMLRQFALILWILWNDRDTYDVFFVDQLSMCVPLLKWFTSSKVLFYCHFPDKMLSVRNSTLKELYRAPIDLLEEWTTSKADTITVNSQFTATIFRKSFRSILKKPRVLYPPINFALYDRQVDMSDITVQILESDRTTCLSINRFERKKNVELALRAFAALSQLVPASEFDNYRLVLAGGYDRRVTENVEYLKELDKLARQTFGLETFIIYPSCTEKPPKTAQVVFLCSFNDAQRTYLLKSSAILLYTPSNEHFGIVPVEAMYASLPVIAANSGGPLETVIDQRTGLILPPEPELWSKGMSDILLSKYDRQEMGRAGHDHVKDKFSLEAFTDQLEDILEELASGGRPSKHKYDNVEYIIRIIIAIAIFIVWYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2F3</accession>
    <name>A0A367J2F3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002455">
        <property type="protein sequence ID" value="RCH84124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2F3"/>
    <dbReference type="STRING" id="86630.A0A367J2F3"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="392" mass="45881" checksum="B453C41CEB5473D3" modified="2018-11-07" version="1">MCTTLFILYCLRHVILIYWAFLKIKLDNAVFDRGYVPCGRLRKQPILYVYDSDHVEIVWETNCGTTDRQMQLTYHAKEEQPITIGPIEPIVLDRYHTVYRTKIGPIEGREIDYLIHDEQRTLTKGTFQWHKHTQDEPIRIAAMADNQFGMLTFVSLLRQVASKKPHYLLHAGDAIQNYPDLRQWQTDFVAPLTFFGLGQTTPMIYAHGNHDFDGTSRYVYSRSSNWFSFSLAQGAIHFIVLDSNLDWESQDDWLQAELETEAFKQAQFRIVVVHVPPFLEYWDPEAWFNLQQSEWSRFVKDRYVPLFEASGVDVVISGHQHNYERGERNGVQYGIIGGAGGDLDREQVKDWGMYEAKLFDFHFVMIELVNNSLIWETFDLHGQRVDRVVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3J2</accession>
    <name>A0A367J3J2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002352">
        <property type="protein sequence ID" value="RCH84483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3J2"/>
    <dbReference type="STRING" id="86630.A0A367J3J2"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="317"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="563" mass="64471" checksum="12DB0E28F5372D3E" modified="2018-11-07" version="1">MKIIEKIEQAQKNNKINYSFEYFPPKTELGYANLIDRIERMAKLGPEFISCTWGAGGSTHERTLELCSTTQSVYGLDTCMHLTCTNMEKDKIDIALKQAKEAGIQNILALRGDPPRGHEYWTPIDNQFTHAIDLVKYIRQQYGDTFCIGVAGYPEGHVDSPNKEQDMQYLKEKVDAGADFIVTQFFYDPEAFINWMQNIRHIGITVPVVPCIMPIPTYQSFRRMIHLCNVKVPTEVMKDLDEIKSDDQKVKDYGVRLAVNIINELHKRANICNFHISTLNLERSTRLILEQLGLIHHTEKLTANKPSPWAPVHDPIKVEMWDEFPNGRYGDSRSPAYGENTYSLNQILPTSQAILKWGQPQSEEDVRQLFKRYIQGELDSLPWCEESPQTETGTICQQLIHLIEQGYLTISSQPAVNGAPSDDKVYGWGPKGGYVYQKAFIEFFISDQAVSELLARLSKDPSVTFYAANRKGDFVTNVTDPDAQNAVTWGVFPSKEIIQPTIIEKASFESWKEEAFGLWKEWEEQYTPNSPSQKLLKDIGDRYWLVNVVHHDFQKPDLLFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3Y2</accession>
    <name>A0A367J3Y2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002305">
        <property type="protein sequence ID" value="RCH84650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3Y2"/>
    <dbReference type="STRING" id="86630.A0A367J3Y2"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="58"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH84650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="50022" checksum="4EAD2E8D3C16E88B" modified="2018-11-07" version="1">MTNYHSIVDNSDRASSVSSYRANSEFGNALDYYRPLLTNDTEDISICHTVFPTDEPSATITSCSINLANTILGTGMLAMPAALASIGLIPGIILILYAGCTSALGLYFLSQCAARVGDRHASFSALSKLTWPKLGIFFDLAIAIKCFGVAISYLIIIGDLMPQVIISFFHDAEQNALLMDRRLWITLFMITAVGPLSYLKRLDSLKYTSLVALFAVGYLVAIVVYHYISPNFPSPPPESIEYFHFSTKVFGQLPVFIFAFTCHQNIFSIYNELSDNSERSIIRVIANSIGSAAFIYELVAILGYLSFGKDVNGNIILEYPQSYFVAYGRLAIVILVIFSYPLQAHPCRASLEKTLVQHTTHKRSHFLLTTAIVVCSYLVAITITQLDVVLSFVGSTGSTTISFILPGLFYFKIFQDDHWYHWKRIVSLFLAIYGALVMCICLSFNIMRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J436</accession>
    <name>A0A367J436_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_003860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002297">
        <property type="protein sequence ID" value="RCH84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J436"/>
    <dbReference type="STRING" id="86630.A0A367J436"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="554" mass="60992" checksum="4ECCB75FDE73FAEC" modified="2018-11-07" version="1">MTLEQERDPLLRNQAIDYHTVDPTDRGDEENRLRKQHDHEDILKTRLGKITLPMVTTCLCIGSFLAAMDTSIVTTVFNEIGTEFKSSNLSVWIMTSYMLSTSALQPLYGKLSDIFGRKTTLVAILCFFLLGSWLCGAANTMTQMSIARAIAGLGGGGLMTMASVVIHDLLPLRERGKYQSYVNMAQTVGTTIGAPLGGLINDTFGWRYCFYLNVPPCLFILYCYIYRLENYNLSQDTSAFSDLRKKLRSIDLAGAGFMLIANVCFVTSTSLGGNTREWTDPLVVTLLITAIAMFILFGVYEIYWAKNPIVSKKLMKNRNVAAVCLNNFFLCSSTMVYIYLLPQFFMGVIGYSASSAGLWVLPRTAMVAAGCWVAGRYLGIKGKYKYFIITVMSAHMVTSIGMSTWTETSPLWFELICMNIEGLCFGCVLVATMVALVADIDHSDTASATSMIFLCRSMGWLSGGTITAAILQANFKMSLHKSLSGPEAAKIIEFVRTSISKIRTLSPEVQTIIIASLQVSIHRALLYGVACSILCFLSSTLLRNCQLGSVSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4Y8</accession>
    <name>A0A367J4Y8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002209">
        <property type="protein sequence ID" value="RCH85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4Y8"/>
    <dbReference type="STRING" id="86630.A0A367J4Y8"/>
    <dbReference type="OrthoDB" id="2349151at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="15617" checksum="EFAFB861657CE62D" modified="2018-11-07" version="1">MYLRCSIALTSICTKTDSPAPLSMIIETKANVRMSFWHSKVVTSVASRGIDIKNAMYVINYDMTPHIDEYIHRIGRTARVGTAGLATSFFNGANTTVTKDQTKVLILVISVSFSNNLLRFTLLLTTDQNCSIGLSSGEYDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J559</accession>
    <name>A0A367J559_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_004788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002189">
        <property type="protein sequence ID" value="RCH85077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J559"/>
    <dbReference type="STRING" id="86630.A0A367J559"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="412" mass="46734" checksum="1DEE47BC26B01307" modified="2018-11-07" version="1">MSELIKKSRWMSDEDEQEVKKEPKKRKQDKAKSEKPPERQNVVRSVRSEVVYPYLRECRHVDSYERLNHIEEGSYGIVFRAKDKETGDIVALKKLKLELANGGFPVTSLREIHALMNIKHPNIVNVREIVVGNHMDQVFIVMDFIEHDLKGLMQDMRAPFLQSEIKTLMIQLLSAVALMHDNWIIHRDLKTSNLLLNNRGEIKVADFGLARKYGSPMGHMTQLVVTLWYRAPELLLGAKEYTTAIDMWSVGCIFAELLNNEPLLPGRSELDQLDKIFKLLGRPSEEIWPGYSDLPHAKNISPAYQPYSTLRSKFTNLTQAGLDLLSKLLTYDPAKRITAEQALKHHYFSESPAPKDPALFPTWPSKGSGHRKHTYSPSAPTAIHGEQIEDAGLEGTIFGGQADTAGFRLKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J593</accession>
    <name>A0A367J593_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002180">
        <property type="protein sequence ID" value="RCH85112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J593"/>
    <dbReference type="STRING" id="86630.A0A367J593"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="65" mass="7337" checksum="73B616B767542440" modified="2018-11-07" version="1">MHNESDFATDTVIEDQVLSDKPRILLMGLQRSGKSSIQRVVFGKMPPNDTLYLESTTKIQKEDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6I3</accession>
    <name>A0A367J6I3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002078">
        <property type="protein sequence ID" value="RCH85520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6I3"/>
    <dbReference type="STRING" id="86630.A0A367J6I3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="275" mass="31096" checksum="39DC75270F533B32" modified="2018-11-07" version="1">MSEHKSCINIEEGENNPRDVSSISTPIVSKIPNLQLFPSKSTVLAKSSLVSVVDKDLSKTTDSQLAKTRKITPELGILRARSLSIGSTISASHDHSRKSSIAEKGEGTKDAIVTEEYEFFKRQGDVQISIKDIKQQGLKALLRSSVPLGYFLYYLMTEYCSENLFFYLAVDNYQRYEFSNQAERRRMASKIAKTYLESTSEVEANLEDRIHKTVKKALEQQQKVPTASSGNEFDAAKRHVFTLLNSSYHRFRISPIWSIMESKCSKIHSIINISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6R8</accession>
    <name>A0A367J6R8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002051">
        <property type="protein sequence ID" value="RCH85623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6R8"/>
    <dbReference type="STRING" id="86630.A0A367J6R8"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052835">
        <property type="entry name" value="Nepro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761:SF1">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="34065" checksum="C0039D8CE1E1318D" modified="2018-11-07" version="1">MTPPPYYTLLDPPVPTKSVLSDVRINKSIKINHQQELEKLKGFLDSFKDQKLFWIEVTLIDRLYYKNVNQQRPFHRFKRSMEIRKLVKRLKALAIEKELERLYLSFWNAKTLDKCTGKWTFIPSKESIQYTMHRLIGAALILDKLKIVLVETYRANSTLLKLEHFVSLALVFMGICSRMYSLSQAWISQIEGCYQQLYSWSEAFPTGLKQKEYDLFISSHNLACTRDTMKEARSTFAEQWMTLKSSIHHKTHLETYLANQAVVDKAKEIQKEIGVKSADPLSFDLEEDLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6T0</accession>
    <name>A0A367J6T0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002053">
        <property type="protein sequence ID" value="RCH85616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6T0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017009341" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9518" checksum="2CB923962C2DB0A5" modified="2018-11-07" version="1">MNLFGVFVSFFLLFSNFEYIATTKYHRGALLTPLTTPSVSSPRGQRKKRLNYLHGNGKEDWPPESFVSSIQSYQHQPINFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7N4</accession>
    <name>A0A367J7N4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STE20_4</name>
        <name evidence="14" type="ORF">CU097_003963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001973">
        <property type="protein sequence ID" value="RCH85957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7N4"/>
    <dbReference type="STRING" id="86630.A0A367J7N4"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="123"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH85957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="42844" checksum="91B484CF38C0E98B" modified="2018-11-07" version="1">MQTAANNKKLKKKSISDNSTATKATSFKSDSNKRTSNIWRSPGQCCEIPNILGNTYLAPFTVQTDKPKKPKEGPKRPPWIPAGYNWTPSPLPPIIRSDETLFEKRLRKALPKLSIAVSPKSRYIGSKEIGTGVNGAVIQVHVKNNAAQKLALKKCKLNHDKEYRTAIIRELRIMSTGHSHIIKVREVSLYQSDIWIAMDLMRCSVFAVLCVRALPEEYAILVAKETLKALEFLHCKGFIHRDIKCENLLISQNGEIKLADFGLATTKKHLNRERLGTAKWMSPEVIREEFYDEKVDLWSLGITIIEMMDRVPPHYNIKSDEKVFQKILKEPSPTFSFSYPTIYCTGLVAWLLEEDPINRPSATEVIRELNNLFIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7N8</accession>
    <name>A0A367J7N8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001968">
        <property type="protein sequence ID" value="RCH85982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7N8"/>
    <dbReference type="STRING" id="86630.A0A367J7N8"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11600">
        <property type="entry name" value="CAF1A_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 p150 subunit acidic region" evidence="8">
        <location>
            <begin position="229"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="9">
        <location>
            <begin position="450"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="659" mass="76695" checksum="A7C44682A39F8669" modified="2018-11-07" version="1" fragment="single">MTETMQTHPMEVDADHSSIPIVDLSEKMKTLQCEEPNGTIQSCAYLKNGKLDFYEPKLLLENHMLIAQKIIFFRDFRYKIETTHDLHTHPLEIPPAYLDVIASVIQDSDESLYALTSRVNDLLSPYGRDESLSHKFESAIQKAIEQVATRVKYGLSKEVYKSIKNTTDKMPWHLYIYRWEVKDMNFFPPEIQQAVLARKKKRMEMSEEVSNYIKSLPVEESLGLINAKHRRADNNEKWSAKIEKERQQREEDKKKWEDEKKRRQEEQRQREEEKKKKREEEKKLKEEQKIKREEEKKLKEEQRIKREEEKKLKEEQKKKREDDKKKKEQSQLRLTSLFTKAAPNENTIPEKIVEPSKPTLFPPFYVKDNVTITENTTFNWPSPSSDTDDFVNKIRSPSNNINVHTFLSELPSEAKQKRGFTPSIDIRTLLLPGSADLLNTPHVRMTLRMKLLQFTEDVRPAYYGTFTQKSSVITGKTPFAQDTSNFDYEVDSEAEWEPEGEGEEINSGDEDEEEVSDYVDPEDSGWVVPEGYLSDNEGVEGEHDQLNKPRTTNAPKKKAVIRKIVLGPYFEGETDQDEAMKPFEMQFLIDIPEQGFDPFFEEPSRKNTSNITSFTNAANIGISSTPQSSIPNHNKVEFTEEHKNALINLINEKQSDSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8S8</accession>
    <name>A0A367J8S8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001894">
        <property type="protein sequence ID" value="RCH86320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8S8"/>
    <dbReference type="STRING" id="86630.A0A367J8S8"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="69"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="354"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="748" mass="86104" checksum="439180946A298F1E" modified="2018-11-07" version="1">MPSNSSDQKDRSYGLQLESEIEAKEEGCEQLPQGVRYVADTRRQSINPEHFTKFNLENTTFGHRRHGYLPIENYGIIGNMRTIALVGTDSSIDFYCYPKFDSPTIFCRVLDKDKGGHFSVNPCTRYSSNKQMYLPNSNILTTRFLSDEGVAEITDFMHVPIQGQNLSTKPLLPWIIRKVSVIRGKVSFRMECYPAFNFGMNEHTTEIVRDQTSKEHEEAVGFEAKLYNDRDLHYYTAQDRAIFKTKDLTMDLRYLVKCGEFDCPRVQCVIDHDDKHHKGPGVYAVFELQETQEVEFVFREVPKKELVDNESPVDRKLRIAIDPPLTLSLLDALFRQTSMFWLNWVSESTYKGRWREHVLRSALTLKLLTYEPTGAVVASPTFGLPEAIGGPRNWDYRYAWIRDSSFTIYAFLRLGFTKEAGQFMKYIEDRCSDLNEDGSLNIMYSIDGVKRLDETELTHLDGYRGSRPVRIGNGAYDHLQLDIYGELMDGIYLYNKYGSPISYDMWCSVRKLANYVCANWNQPDMSIWEVRGRKQHFTYSLVMCWVAIDRALRLAEKRVFPCPDRQKWMNTRDEIYELVQTRCYNKELQTFTMSIESPDALDASTLIMPLVFFSSPSDPRLLNTIKRILLPPEKGGLVANDLVFRYNFLTTDDGVGGLEGAFSMCTFWLVEALTRAGKYDKRLLTRAVVMFEKMLGYGNHLGLFSEEVARSGEMLGNFPQAFTHLSFISAAYNLDRVLSGSHRESGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J953</accession>
    <name>A0A367J953_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PGM2_2</name>
        <name evidence="17" type="ORF">CU097_008308</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001854">
        <property type="protein sequence ID" value="RCH86494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J953"/>
    <dbReference type="STRING" id="86630.A0A367J953"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="189"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="303"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH86494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="557" mass="61237" checksum="CEF5CA692A1BC618" modified="2018-11-07" version="1">MVNIQTIPTKPFEGQKPGTSGLRKRVKVFQEKNYTENFVQAILEAIPESDGGAKGATLVIGGDGRYYSNEVLQVIVKCSVAHGVSKLIVGRNGIVSTPAASNIIRKHKATGGILLTASHNPGGPDNDFGIKYNCSNGGPAPESVTDRIYEISKNIKELKLADVPEIDFSKLGTQTVGDMTIEVIDGVDDYVELMKEIFDFDSIKEFFKKNTDFKMLFDGMNGVTGPYGYRLFVEEFGLPESNVMRCKPLPDFGGGHPDPNLTYAHDLVEAVNKQGFDFGAASDGDGDRNMIIGKNAFVTPSDSVAIIAHYAKDAIPYFKKHGVKGLARSMPTSQAVDLVAKKMGVEHFEVPTGWKFFGNLMDAGRCSICGEESFGTGSDHIREKDGVWAILAWLSIIAHVNKEKRASVQDILQEHYKIYGRNFFSRYDYEEVDSKGAEEMVDYLRGLIEKNELVDKTFGGFTVAAADDFEYKDPIDGSVAKKQGIRIVFKDGSRIIIRLSGTGSQGATVRLYVEKYTNDASEYTKDTQVALKPLIDVALDLSQLEKYTGRKEPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J984</accession>
    <name>A0A367J984_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RWD domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RWDD1_1</name>
        <name evidence="4" type="ORF">CU097_007794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001858">
        <property type="protein sequence ID" value="RCH86476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J984"/>
    <dbReference type="STRING" id="86630.A0A367J984"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="238" mass="27511" checksum="18FAA5C02E09E69D" modified="2018-11-07" version="1">MTDYLEEQKNEIEALQSIYPDEFEGISETEFRISIYPEEQDLENPRALSLHVIYTPNYPDELPEYEIEIIQGQVPESYLSRIEQSVKQAAEESIGMAMVFSLVMIIKEELDNIVLDVKRAEEELVKEKKRKEEEAEQAKFVGTKVTRDSFLDWKKKFDAEIAEKDAVARAQKAKELKGKLTGRQLFEQDKTLAMSDAGYMDEGDVSVDVSQFDKEDRAGAFDDQYKDEEENPVWKNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9F6</accession>
    <name>A0A367J9F6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001840">
        <property type="protein sequence ID" value="RCH86568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9F6"/>
    <dbReference type="STRING" id="86630.A0A367J9F6"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="204"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41440" checksum="CAE70499C849ABC9" modified="2018-11-07" version="1" fragment="single">MVLGKLDIKVDIRLDEDKKYFPGDTIVGKIILRANQNHTLRKLWLIWTGRIQVQPRENEKESHDYFVDCWKLCSPIFKSPVRIDKNIPIYHTAFVNYSPNENTNDDESEPMLLELAKNKPVAFAFEAKVPDDIPLPSSTKNEFAAHKIVYYLEAFTGTSHVFSKSRAIQVYEPIYVMTPLMMTPQRAERVFSVVANSKHFCTSSMQLIVPCQGHIQGTIVPISIIVQSEYELTRKQGISVSLLRTHEVMVNGRKFSSFVEPVSRSVGDLHLTSQNGNPSQTVEIKLQIPKDAVPTIAMEQSKIMAVNYYIRALVYAHEGTYISQDLQESQFMSAELPFIIGTLKEPPAALSSPPISPQTSPALSAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAQ6</accession>
    <name>A0A367JAQ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001745">
        <property type="protein sequence ID" value="RCH87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAQ6"/>
    <dbReference type="STRING" id="86630.A0A367JAQ6"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15657">
        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15657:SF1">
        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="19584" checksum="5FF2A607C0F01A03" modified="2018-11-07" version="1">MPPKKHRKPLTPLQRKQIKRKRELIHKATVKSQYYKELNQQKDDTPDYVKEVFGMQERTIDENGNVVELHKPEDEKEQGKRQNKPNPFKSQMEESLKRKRESEQERREKEEKLKEQKEQRHAYYKERSEKRRKMLSKTKRGQPKMAARMDVLLEKIEKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAW5</accession>
    <name>A0A367JAW5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein sds23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SDS23_3</name>
        <name evidence="5" type="ORF">CU097_010284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001734">
        <property type="protein sequence ID" value="RCH87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAW5"/>
    <dbReference type="STRING" id="86630.A0A367JAW5"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="24831" checksum="5DDC596AF311EB47" modified="2018-11-07" version="1" fragment="single">MNHYQDWREIKVSTLVKDQKVIEISSKISIEEACQVLFENNISSAPIKHEGNYIGVFDYGDVIAYILLVLQPRDKEKEGYSIQDIMNKALKGEKVSVGLVSDLSRKNPFYSIQQDSTLSSVIEIFALGTRRVCVKKPDGGIQAILSQSTVIQYLYEHTKQFPELSECMNKTIHQLNLGKEPVISVPANATVLNALYQGQHGVSSLAVVSNDKIIGNISMTDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBN2</accession>
    <name>A0A367JBN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_006138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001678">
        <property type="protein sequence ID" value="RCH87338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBN2"/>
    <dbReference type="STRING" id="86630.A0A367JBN2"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="82"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="507" mass="57217" checksum="1AC55706F7E53014" modified="2018-11-07" version="1">MSSRVLLRRLFQQSQSTVTRRTVNALPTIARMSMNANRRLIQTRYILSGQNAKKMYSTSSTSISGLESAQTEVIHKSNLAVREVILNRPKKLNALSLPMVRSILPELQSWEKSDLAKIILLKHSGGKGFCAGGDVKTVVDLAEAKDPNAAKFFEEEYQLDHLIATLETPFVSIMNGITMGGGVGLSVHAPFRIATENTLFAMPETAIGFLPEVGGSFFLPRLDGQLGLYLGLTGKRLKGVDVLYSGVATHYVPSSRLSALEARLAELEEPTHDMVNQAIEEFSAELEAEPTFSLGGPIRQAIDRCFKYDTIEEIIKALEKDEQTEWAQETLKLLRSMSPTSLKVTIQQIRNGSTLSISQCFKMEYHLVQKFLQGHDFKEGVYATLVRRDKANWKPSDLKEVDARQIKQDYFDSPSPLRLDFLVKRDYKKYPHRKYMLPSEQDIMRVVTGEASDVGNYALNRQQVIDYFVRERQGKQGVKQKVAEVLDRKTIEIEKDADKSLKWVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCT7</accession>
    <name>A0A367JCT7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001596">
        <property type="protein sequence ID" value="RCH87758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCT7"/>
    <dbReference type="STRING" id="86630.A0A367JCT7"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH87758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31523" checksum="E136412D4D5E97B0" modified="2018-11-07" version="1" fragment="single">MPTISISKHASTALILASGMLISGVCNTILNKYQDMQCVDHCDDPDPKKRIYFEQPLWQTLNMFVGEFAVWAVYLYQLYEKRYQTTIAPPSSVNQLDASALIDDVDNEVQKVENTLPELKGIKSLLFWIPTVCDLTATTMMNVGLILTSASVYQMLRGAVVIFTGAFSYLFLNRRLRGYEWFSLVLVVLGVAIVGLSSVLYPQNSPHAAGASMDYASLIGVCLVLGAQLFTASQFVIEEKIMMHYKVTPLKAVGLEGTFGMVSILASMPFLHFTLGQRYPSFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDT8</accession>
    <name>A0A367JDT8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coth protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001538">
        <property type="protein sequence ID" value="RCH88055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDT8"/>
    <dbReference type="STRING" id="86630.A0A367JDT8"/>
    <dbReference type="OrthoDB" id="2387105at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016976549" description="Coth protein-domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66168" checksum="96825B423D32D869" modified="2018-11-07" version="1">MKLSLAIISSALLVAVHAANIQFNVIAPSATDVKVSVNGQQVALKASNPSVPYFTGTAETGSATTYKYVVGGTEESFDRSLKGITNSTYNDFINRPVTYANLPQLPWPIENNPQWTRKGPKPEIFDDNYIPTVFFQGDDTQVTNLVKNVPADRVSGTLTFIGANYVHTFQNVSFGIHGAGKKHNNAKQSWNWRLSGSDSMGNRNFFKLRHMEEDPTQLRERLYADVLHAMGTYANEATMVRLFINGQGFGTFNMLDDITDFSFINAMFYAGKPPATLGPLFDGASGADFQYHPGNLDGYASWVANKNNPNGEAYEALDPLCKAWNETNYSDNNAIANFEKMFDVDHFLRFMVMEYLAGHWDGYWMGQTNDGAYRDPTDNNKWYFIDQDFDGTFGVNLAVPEGNNFISVSYKEFPNRYPAAVMINGLLKNPDKQALFEKYLKDTVSVLFNNVTLTNRVLALHDFLLPDLQWDRSIVQQSPGINFGWTFDQVTQNLWQGVSAPNANGGGAAWGLVEWIAARSQAMAKEFNISITTTPVGPPTNSSTTSPATGNNNNTTSSSKPISSSNSSTTNKDASAQSASSATRPAASVAFVAISALAAAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEI3</accession>
    <name>A0A367JEI3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001486">
        <property type="protein sequence ID" value="RCH88330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEI3"/>
    <dbReference type="STRING" id="86630.A0A367JEI3"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="66"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="29420" checksum="C5629E919B35BB2B" modified="2018-11-07" version="1">MTTATTTTTTTTAAAVSSTATIATTTFKSASTSLSQRRKNKKNLSLCLPQTTLSTPVKTTDPYSNGPIEIMPHLYLGSEQNTLNMDQLRELNIQSILNVAAEVSHPYQDMFQSIQSIIPSPTLSKSSTISSTSTIHTNYSSDSLLHHPSDIIYHKLNWEHNQDNLVLELEKAIDIIDRSRSVNQNILVHCQCGVSRSATVIIAYIIKTLKLPMQDAYNHVKNLSPAINPNLSLLFQLREFEQFTLKKKPHFLFSCSLTSKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JET5</accession>
    <name>A0A367JET5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">STT3</name>
        <name evidence="24" type="ORF">CU097_006832</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01001461">
        <property type="protein sequence ID" value="RCH88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JET5"/>
    <dbReference type="STRING" id="86630.A0A367JET5"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="13"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="535"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="721"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCH88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="750" mass="85299" checksum="57FC3A78A20FDF49" modified="2018-11-07" version="1">MAQLDVSSQKILLKRSILGLIAVVAFASRLFSIVRYESIIHEFDPWFNYRATRMLVKDGFYEFWNWFDDRSWYPLGRVVGGTVYPGLMVTAAIIHNVLHFLNFPVDIRNICVLLAPMFSGLTALATYLLTSELKDSSAGLLAAAFIGIAPGYISRSVAGSYDNEAIAIFLLMFTFYLWIKALKLGSALWASASAFFYFYMVAAWGGYVFIINLIPLHVFVLMLMGRFSNRVYVSYSTFYVLGTLMSMQIPFVGFQPTRTSEHMAALGVFGLCQIMGFVNLLRSHLQARQFQIILKAFVGITFVVGFSAIVGLTLTGYIAPWTGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPMFFFDLHMLVFLFPVGIYLCFEKLRDEHVFVIVYSIFASYFAGVMVRLMLTLTPVVCICGGIAISTLLDTYLKLDSGSSGKENKKEDKGSTSKKDDKSSKKKASTKSQASGILGAGPRILVVGCFTFMLMMFVWHCTWVTSNAYSSPSVVLASRNPDGSQRIIDDFREAYYWLRKNTDEDAKIMSWWDYGYQIAGFSNRTTLVDNNTWNNTHIATVGRAMATNEDDAYEIMKRHDVDYVLVIFGGLLGYSGDDINKFLWMIRIAQGIWPDKIKESDYFTATGEYRVDDQASKAMRESLMYKMSYYRFNELFGGRQPFDRVRNQPLPMQGPELSVLEEAFTSENWIVRIYKVKDYDTLGRDHKDAMLFQNGKKKYKSKKSKKTENRRRRAAAAYDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH33</accession>
    <name>A0A367JH33_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PGK1</name>
        <name evidence="20" type="ORF">CU097_003359</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="PJQL01001333">
        <property type="protein sequence ID" value="RCH89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH33"/>
    <dbReference type="STRING" id="86630.A0A367JH33"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="416" mass="44588" checksum="764A17C93DBD504D" modified="2018-11-07" version="1">MSLSNKLSIRDLDLKDKRVLIRVDFNVPMKDGAITNNNRIVQALPTVQYALDNGASAVILMSHLGRPNGEVVDKYSLKPVAAEVEKLLNKPVQFLNDCVGPEVEKACQSATGGKVILLENLRFHIEEEGSAKKDGQKVKADPEAVQKFRASLTSLADVYVNDAFGTAHRAHSSMVGVDLPQRAAGFLMQKELEYFAKALENPSRPFLAILGGAKVSDKIQLIENMLDKVNALIICGGMAFTFKKTLNNVKIGTSLFDEAGAKLVDNLVKKAAEKNVKLVFPVDFITADKFDANAKTGYATDADGIPDDWMGLDCGEQSSKLFREEILKSKTIVWNGPSGVFEFDAFANGTKSVLEAVIEATKEGATTIIGGGDTATAALKWGAGDKVSHISTGGGASLELLEGKELPGVTALSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHJ3</accession>
    <name>A0A367JHJ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-binding cassette, sub-B (MDR TAP), member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABCB4_2</name>
        <name evidence="16" type="ORF">CU097_009406</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with 1-naphthylphthalamic acid (NPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001293">
        <property type="protein sequence ID" value="RCH89410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JHJ3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="740"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="87"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="411"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="744"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1069"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="669"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH89410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1317" mass="144910" checksum="F4A2FAE998E1A6AC" modified="2018-11-07" version="1">MTEALSTSRSSSTVQSTEEIVIKSTSIEKHEDHLLLEEIAAAKNVKIEEESADKTKKGKKEKKEKQPAVPIYKLFRFATKIEILMILTACVFSAGIGAMQPVSIIIFGKFMSTIGNSMATGDFAHLVEASHPLVLIFVYMGTAVLACAYIAQCFWVLTGENQVRRIRNMYVHAILRQDMAWFDKAEEGSLTTRLATDTQLIQDGISEKFGILIMCVGQFVAGFVTAFVKGWRLAVVILATLPLMAGCGAAMGHFITKYTLKAQDSYADAGAVAEQVFSGIRTVYSFSLQNRFAELYAKKLEKAMKTGIQRGQILGLGFGSFMFILFCTYGLSFWYGSKLTRDHMMDGSDVMVVFFAMIMGAMALLQLPQNLSAVSSACGAAYKIYATIDRVPTIDPDNTEGLKPEKFTAEIEFKDVMFKYPTRPDITILKKLNLKIRPGMTVAFVGPSGSGKSTSVQLIQRFYDPNEGQVLLDGHDLKEYNVSWLRSQIGVVSQEPVLFNMTIKQNLLMGVSHQVSSEEIIEACKKANCHSFISQLPNGYETMVGEHGGMLSGGQKQRIAIARAILKNPSILLLDEATSALDTQSERLVQAALDAASADRTTIVIAHRLSTIRNADLIVVMQQGDLIEQGTHNELLALDGVYADLVRKQEIATKQVGVDVEEPDAEELLQREQMEIARELNNDEKLDEKDTTSQLIKISSHASSVDAFEIKLRKAKAERKAAKKQSIPMGKVLKQMRPEWPLLATGVVGAAIAGAVFPLFSLIFARVIAMLIDPFSAPPGPMSGTNLYAFLFVVLGIGAFIGFSCQVISFEVAGERYTKRLRADIFRAFMKQEIGFYDQEDNSLGALTSKLAIDSKNVNELVTKTWGDVTQIIVTAITGLAIAFSQTWALTLVILCMAPFIGGATFYESTIHRGFEDKTKKANEQSGEVAGEAIKEIRTVSALNKQAYFENKYHRATDHPHYLAQKKAYTSAVGYALQQGIILYTNAVAFYAGTNFIAKGMIDFQRMFTCMMAIMITAQGVGRASVFTSTLSKAKFSAIAAFEILEREPEIDPELEGIEPSHSQIKGDIDFENITFRYPARPDTAIFNGEFNLHGKAGQTIALVGPSGCGKSTTIGMLQRWYDPVSGTVRLDDNNVKNYSLHNLRSHMALVGQEPVLFDMTIGENIRFGVDEGTQVTQEQVEDACRAANIHKFISNLPNGYDTRVGDKGSQLSGGQKQRIAIARALIRRPKVLLLDEATSALDSESEKLVQAAIDNILEEGGRTTITIAHRLSTIQNADLICVVKNGRVIEQGTHWELLKLNGVYTELVHQQSLNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIR8</accession>
    <name>A0A367JIR8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001228">
        <property type="protein sequence ID" value="RCH89785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIR8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="125" mass="14138" checksum="C2DB753C91E62D9A" modified="2018-11-07" version="1">MEQDTKNAYQEATLAKFNGMTDIDEIDCTILVKSLLRKRRRSVDKRTVDIETDITHLREKRPFVGKRTIGVQTDIVPSKKKRSFIGRKTVGIQTDSTPGLASTSVDPLEHAQHILNLRVLPQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM07</accession>
    <name>A0A367JM07_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001051">
        <property type="protein sequence ID" value="RCH90899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM07"/>
    <dbReference type="OrthoDB" id="2281119at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="236" mass="26906" checksum="2C287A9C80187686" modified="2018-11-07" version="1">MNIPATFTLAPGYIPGTDFVTRFLLQDERIMDIIVKEVAGQNVDNTAYGLGRCAWASKCISDAVYIPKLPHLSPILVEVQCDINEDFIARLVSYSLQLKQEYGQLPKVLVISIKSITTEVKSKFKNLENNCMYTMNCDFWAEICQIISAESIQTHLNKNPLNKLAALGHFLIQQKRNILSIGQKHDPTIQLLYQILKDKFENECYVEEEKLVVIKDLCFKAKTQFEKIVKCLQNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM91</accession>
    <name>A0A367JM91_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPS0_3</name>
        <name evidence="6" type="synonym">RPS0</name>
        <name evidence="8" type="ORF">CU097_012482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001029">
        <property type="protein sequence ID" value="RCH91046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM91"/>
    <dbReference type="STRING" id="86630.A0A367JM91"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="30875" checksum="8043D3B629CE2E9E" modified="2018-11-07" version="1">MSKVPAILNPTEEDLQLLLAAKAHIGTKNLNARMKPYVFKRRSDGVHLINLGKTWEKIIFAARVIATIENPADIVVIAASSYGHRAALKFAKYIGAEAIVGRFTPGTFTNYITRSFREPRLVICTDPRADFQAILEASYVNIPVISLADADASLQYVDVAIPTNNKGKHAIGLIYWLLARSVLRLRGTLDYNTPWDVMVDMFFYRDPEEIEKENEAAELAEEAGRFDYGATTEDQDWTIEAEGPSSFAATAADWNTEAPSGEVGDWAEDVSAAPASSGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMW8</accession>
    <name>A0A367JMW8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UGP1_2</name>
        <name evidence="7" type="ORF">CU097_012824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000994">
        <property type="protein sequence ID" value="RCH91276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMW8"/>
    <dbReference type="STRING" id="86630.A0A367JMW8"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="33671" checksum="C9739169BA9C90FD" modified="2018-11-07" version="1">MLPVPRSPDSPIEQWYPPGHGDLYESIYNSGLLDQLIAQGKEYLFVSNVDNLGATVDLNILHHMVESGAEFIMEVTDKTKADIKGGTLVDDDGHIRLLEIAQVPDEHVEDFKSVKKFKIFNTNNLWINLKAIKRVMDEEAMDLEIIVNHKTTPQGEKVIQLETAVGAAIKHFRNAHGVNVPRARFLPVKSTSDLFLVTSNLYSLVHGQLIMNPDRMFNNVPLVKLGDHFKKVSDFLTRFKTIPKILELDHLTVTGDVCFGSKVELRGTVIIVANHGEHIDIPSGTVLENKVVTGCLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMX6</accession>
    <name>A0A367JMX6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_011397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001003">
        <property type="protein sequence ID" value="RCH91219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMX6"/>
    <dbReference type="STRING" id="86630.A0A367JMX6"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="641"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="519"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="690"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH91219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="839" mass="93412" checksum="0ECB7D0D68813057" modified="2018-11-07" version="1">MDIQQQQQQQQQQQQQQQQELNNLISCNYHQSYEIKPIIDSSKDDNNNNNNTNSLNHSNSSSATSTPLPQLYSDVISVHSVMPQSTDNQINIEQNTLANAGHATLLTDSPNPLIHSNVISTADQSQLSSPQLSVPNHASPTDPVGSMVSNEATNELINNNGLVLPHGNMFINSSSPPIHLNQSPFYDQNIQQIQPQVSMQLQEISSHLPTQQQQQQQQQQQQSSFGIIAQPSIEHHPIVPSQRTLEHAHTVPSQAQSTLEEHQERVAAAAQQVMAQQIAQQYAIIQHQQVVNEHILQSQQSAQSVQPQSQPMPIQHQFLMNNDPGQPPTAPSQETPHVVLSQMSMLSPSSPNPSLVNNLANANGNTTATTTPVATPTSSLQNAIFHQHIHRTNFVHESNKRPAAGQSTLIERKKSRRHTVSNGQPPVLSIDTKDIPALSSSPRSDVVLVPSQPFTRSEERKAFIDQQKKSLGTIKIPPPPTPQELGMVQSASAISAKDYEGLTRAQLISRLIELETEKIQNDNSDNKEKGEEEEASPSDNQESKPDSATVDEDKSTVDEEEEEESVEEEPKTEKMQCKWRDCGIYLDELQKLITHINTEHVGSGKASYSCEWENCPRKEKPFTKRHKMYNHLRTHTGERPFVCTQDGCGKKFSRPDSLTTHIKTHSNVRPYTCYVKNCGKSYYHARSLRKHEKTHEESPTTMLSTPNSSIQYSGVSPAATSTNSTPFSSNMPGHIQVDYLNSPIQHSPLPVQTPSLPNSPHPPVPQQQQNFTMLQSQTSSPVNKSYTPPNHMLSFSPAGMVEQQQQQQNNELSINQQQQQLLDSVNQQHNTAFGYGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP02</accession>
    <name>A0A367JP02_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_011695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000971">
        <property type="protein sequence ID" value="RCH91431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP02"/>
    <dbReference type="STRING" id="86630.A0A367JP02"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000003">
        <property type="entry name" value="Related to J kappa-recombination signal binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="7">
        <location>
            <begin position="103"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="8">
        <location>
            <begin position="247"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="669" mass="74328" checksum="4F2826380B75EA69" modified="2018-11-07" version="1">MNYPELLSNFFYDPSSTTSSLNHVTTPDLFSPSFLDALKQEQDYLMTIHPSIITQHSPSNTSISSPISNYSNHNVHTMPEDDLIIRLRPFIRHYLHSNQGERKITILTSKVAQKSYGTEKRFLCPPPSTILSGTDSWFPLNQYSPEITVQITGEQPVHQTTIDWYQDNSLLDPSSAISAARHGHALKGSCVSKQLHINDADEKRKHVQAHVKINLGHGVSLGTFDSKNIKVISKPSKKRQSLKNMDLCIHHGSTVALFNRVRSQTVSTKYLGVSSLPDSGTCFVTRTSSWDPFLIWIVDLHRSSDAPVPKHHPDNPHYPAPPAIAIQTSAGQSPIALHYNQPIVLQCVTTGLVSPVMIIRRVDKASMVMGGNRVDDLSCPTGGEYGDEALGDPVSQLHKVAFQIVQDLSAAQYCQTRCPPSAYIPPMTEWSLPETSPNTIYLACLNEVVGMHKAVSGRSIVSPLDPTRHAYETKPGRKRRLSYQHMPFPTKPSLNRRRVNSLNDGLLLSRHGAGRRLSDDGTDNYYPLNGDCWTEDVSDASVWTIVGTDSVTYSFWTPPEHLLLNSPFSSDTASPITPFPMVHSTQYDQGILTLTGDKFSEEITVWLGDVAINTELKSKQVLSCTVPDTNELKESTAVQLDTSIGKYMIPILLVRKDGIVYNPQLFFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP51</accession>
    <name>A0A367JP51_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Meiotic recombination protein dmc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DMC1_2</name>
        <name evidence="13" type="ORF">CU097_005378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000964">
        <property type="protein sequence ID" value="RCH91481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP51"/>
    <dbReference type="STRING" id="86630.A0A367JP51"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="93"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH91481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="336" mass="36711" checksum="9622923ADFAFDD42" modified="2018-11-07" version="1">MPSKYDDDDAVAAQQENETTKSSQEQLFYTEIDDLQAHGIGVADITKLKTAGLCTVRGVQMTTKRALLKIKGLSETKGPGFVTAKQVAVQREKVVRISTGSKQLDSLLGGGIQTMSLTEAFGEYRTGKTQLAHTLCVQVQLSPEEGGANSKAAYIDTEGTFRPDRISAIADRYGVDPDIVLDNIVVARVWNSDQQMELISELAAHFAEQRGTYRLLVIDSIISLFRCDYSGRGELADRQQKLNQMLNRLQKISEEYNIAVFMTNQVSSDPGGGMTFVADPKKPVGGHVLAHASSTRIYLRKGRGEERVAKLFDSPDMPESEAKYAINSGGIVDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ35</accession>
    <name>A0A367JQ35_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000885">
        <property type="protein sequence ID" value="RCH92038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ35"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="69" mass="7646" checksum="8305ABB4BBCBAFDE" modified="2018-11-07" version="1">MNKIHLVVFVHGMMGSRAHSFYVSERLVKKCPNIQTYISSANEGWLMNDGVDACGLRLAQEASIYGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQD9</accession>
    <name>A0A367JQD9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000879">
        <property type="protein sequence ID" value="RCH92079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQD9"/>
    <dbReference type="STRING" id="86630.A0A367JQD9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="558" mass="63328" checksum="8F4E586D6F73D992" modified="2018-11-07" version="1">MDGHSEEFILTDPVSTTSGKIQGFRDETNQTHVFMGIPYAKPPTGSLRFRPTVPLDTPDTERICTAYPPSAPQTNMPFDTLMCVEINYQSEDCLYMNIWRPASAATDNAKPVIVWFHPGACLSGSCSQPFWDGTHLAKNDVIVVGFNYRLGALGWMSMDHLSSELKGSANLGLLDQITVLKWVQKNISSFGGDPNNVTAFGSSAGAACIMSIILSPNTAGLFHRVILQSPPMFMTSPQDWAEFKGTVFARSLGLDTSNLLSDLQSIEVETFLESQTFMTTWPNFLEGLAPISSSVDNYLLYDTLIERFFHQPLPAGYEQLEIIMGYTRDEFNFFFPFLPNFQEMDESMFVRTYFTHVFGLRNARRAYEIYKQEIVPPMSPPSEVARYMCSDVMCRIATLLASENLVKHGHKVYVYQWDYESNDVQNVIKAAHMVDSIFSWDNLVYWTDNPFLGPGDEYERDRVAKQISRAVVQFAKIGDPNHDGIPLWPVHSLEERSAIVFDREVRVEDNMYQTGVHLWKTILKDYVTNSLFPIKPKTKDITKDDALESTNKRRRVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQE6</accession>
    <name>A0A367JQE6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SMU1_2</name>
        <name evidence="11" type="ORF">CU097_011688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000876">
        <property type="protein sequence ID" value="RCH92105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQE6"/>
    <dbReference type="STRING" id="86630.A0A367JQE6"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH92105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="508" mass="57486" checksum="5472855E121ECBEC" modified="2018-11-07" version="1">MSIEIESEDVIRLILQFLKENQFDETATTLQTETSVKIEHIENKDQFIKEIKQGEWDTVLRHVMDLKIPSQKVIDLYEHIILELVELRELGAARTLLRQTEPMFILKQRYPERYLRLEHTLSRTSLDPREIYPHGATKEKRRQVIAQALASEVTIAEPSRLMKLLNDSIKWQRQQKLLSTDTPIDLFQNPEQTQEIEADAFVNQSYATIKFPGKNTYAECTAFSPDGQYFATGSVDGFIEIWNHLTGKLRKDLRYQADENLMAMDQSVICLSFSLNSELLVSGSTDGKIAIWRVQNGFCQRKYTPAHSQGVTSVRFNKDASEILSCSYDHTVKIHSVKSGKLIREFKGHRAFVNSAIYFADYTRVISASSDGEVKIWDISSGFNISCFPQGNLTIHALLTISEDSAHLVMVNKSNRLHILNSQGKITKSFGQSQAKDFVAAATSHNGTLIYAVSEESIMYCFDVHTEALVGQVQLSDNSEIIGITHHPLSNVIAANNDAGRVFLFKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQP6</accession>
    <name>A0A367JQP6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000859">
        <property type="protein sequence ID" value="RCH92226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQP6"/>
    <dbReference type="STRING" id="86630.A0A367JQP6"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="185" mass="21223" checksum="BE9A92D26C6FCCD0" modified="2018-11-07" version="1">MLLSSNKRSCCLFVPIKTGVYLITTIGLLNKLSGFYGLISLEYGDPFAVLAHVYSLIALFIFSLGLYGINNNHHTLIRSYAIFYWIDFVIGSLMTVYFAFQWFIFTDHSLPEIADDVDKTRQHDDIFKTESIVSITILCVIRMVQIYFACIITEYYLSLNKIKYSKITAVVDEEMSMTETKQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQY4</accession>
    <name>A0A367JQY4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHDC1</name>
        <name evidence="4" type="ORF">CU097_012424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000840">
        <property type="protein sequence ID" value="RCH92362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQY4"/>
    <dbReference type="STRING" id="86630.A0A367JQY4"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="515" mass="57854" checksum="DD4CA3EAC357C203" modified="2018-11-07" version="1">MLTRSVLAYRIAYVDTVNRPMSALPPFINFRAGVAIGTTFYMPFMSESLLCYTFDLLAHEWSSHKLTPIDHDEIHPQVTSAAAIGHKIYLVGGRLLKSYTLSNSLIEIDTRTFTIRIVKDAQGSPPRPRHEHSVDTVDNRYLIVFGGLCYNSVGENDVFVYDSLKNTWFVPPISGQIPHLRFGHASAVIGKDFYVHGGAQIDSDSSYIIYDDLYKLDCNTWVWYKYEHPEVERYFRHQPERGTTLQKEHLIPTTGDSPHDRFQAYMCAASGKLIIFGGHSIRVDEDDDEILCNYPLNELSIFNTRRQSWVTVHAQLVEPQNEASLTVSNMCVAVLPIDSRGARLFVFASKKLDEYGKVTNQLEAAKKAPSESSFSSSDRISSGSLSRSILHDIAETTAQEELPEGRTWQQENSKHVENATGQYAKPEDTQYADRVKEVFQITDPDFKMESSGIGQVDGTSNGGFKTEGPRIDQVDGTSKDSSNSIEPPRRPSIKPIHNDAPKTDHLRTCGVIQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRE7</accession>
    <name>A0A367JRE7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000852">
        <property type="protein sequence ID" value="RCH92271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRE7"/>
    <dbReference type="STRING" id="86630.A0A367JRE7"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="444" mass="52232" checksum="71B0F10D4BEDE451" modified="2018-11-07" version="1">MTQVVSSTPPVLPEHVKKPNEEEYKKNIESINASIEKIQKQFDVVKDKIAKLPAKGDNSRREQIKTELAEIREKQAELKKSRKAVYEQLDALNESIRKKVTVVKGFQSKIPYRSTEEVDARISELERKIEAGVRIVEEKKMLQEISLLKRNRLSFEDIDQQQNEINRERAIYDELKKNIDDSEAKKLSDRYEQLDAEFKTIQEDQNKQREARNKLYDERNRLKGLLDEEYNKLRTLRDEHRKNNDEYYTFIRKLREWKKEQEQLRKVQEENERRQEAAKQELELASLPAFENEIALCDNLSAFLESYLSPNHKNDASADSNASEIANAFEGMVIKKKEDDFFFVGNNKKKHGKNKEAVKDTKKSDALKLPLSTMEAFFDIKVTVPTKISEIPTTLQKLKERKEHFIKEQPKATEANRKKAEERIQAMLKAEEEEKEKEEENKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRH7</accession>
    <name>A0A367JRH7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000812">
        <property type="protein sequence ID" value="RCH92554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRH7"/>
    <dbReference type="STRING" id="86630.A0A367JRH7"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="252"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="412" mass="48333" checksum="C58CD245E363208C" modified="2018-11-07" version="1">MLPCFIFMLVSIPVKKRNIIQELCLLLLWLIGLSVPIYYAGKLPYVYLISTSVWSWGTSMKMGVWLFSMSMEERRQRPFALTILQWRKERYSEKAKVDHHPSHVYINFPLAQFIFSTIKHQIVYDLIEIILRRLDLDRPVRLFSAVIYHCLGMFFNLSVSETELPFSFGNVALSTCTCILFLVYVQMQLQLTYDIFNILFTLMYKSLPTLEKWQLGNKAIDTRDVAKTKAALKRIRGIRAVKVYLEQTISMPPAFNRPWCAYSLRDFWARRWHTYYNECFYRLGYQPIRLIMIPILGRKPPRWLPALSVFVMSGLMHEYFLYAATGPALYFQGTPISACFIQFSFFVSQAVFISIGDRLSLSDGFLGRTYAVLIMILTCHLFVVPYLLTGYLYMPRFSFYRTFVNIYQGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRJ9</accession>
    <name>A0A367JRJ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000813">
        <property type="protein sequence ID" value="RCH92538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRJ9"/>
    <dbReference type="STRING" id="86630.A0A367JRJ9"/>
    <dbReference type="OrthoDB" id="2358153at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="43991" checksum="CC701272A3C6093C" modified="2018-11-07" version="1" fragment="single">NACIVCSKCFTCSKASIHYYGIDCNCPEVQPRRGKNLPEGGLDSRAKKLHRDDPDYEFSINWINENAHTMYKDENDTVIGLRDLSEVSLCKAHSSTLYRAKKRHERMLVTPPSPADSSIQYNPYPMNQSIGSGGLAAKVREISTQYNQVLPVQQQQQDVPDFTRMTPSHSAKRKRSSKPLIRKTGSKSTDLRHSARPHSSMSTPLFNSRMFVDNPMNGPINNQDFMQQVNQFPSQLPPLHTRNNNESNSNMLYNDHLKIHQQQQHQDMDYTNNNMATSNNNNNNNNNIPMVVETVSLRPSNSSDIPSNYYFRNLAITDTFTFRDLLNEIDITGSPPPGKRIVISDEHKIYPLDQAIRSVIRRPTSTHLDLFLGLTDKPSINWNHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRT9</accession>
    <name>A0A367JRT9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_011562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000806">
        <property type="protein sequence ID" value="RCH92595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRT9"/>
    <dbReference type="STRING" id="86630.A0A367JRT9"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="40"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="437" mass="48008" checksum="911094141594223A" modified="2018-11-07" version="1">MIKKYFSSSKDESTDTVCDYEVTTEANQDKLQFGIDRSKQGSSFTAFFNVVCVVAGTGALGLPYALSQGGWIGLFILGLSWILSVYTGIILIKSMYYDGTHRLSSYQEVAEAAFGPIGGWLAFFFTAITLVGVPVLYLLLSGLNLHNVAKGTSAELTFPIWVIICTAIVAVPFLFFRSLKEIGILSCFGMLSTVIVILIVLGVAVQQHVPAEQVHHDSVIWDMFPIALSSIVFSFGGNPVYAHVEAGMRRPKDWNKVCFTGLTFCVILYFLTAVPGYYVYGTSVKSPVYDSLPDGGPKSASIIIITIHLILATPILLTSFAIDVEKMLKISPDHRSFVVEWALRWLFRGALIVAIAVIAIFVPFFGDFMSLLGAFSNCALVFIFPVIFYYKLTGIRGKPWYDYILGFLTLLLGIVGLIFGTISAIKALNNDFKSQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS62</accession>
    <name>A0A367JS62_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, AN1-type domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZFAND2B</name>
        <name evidence="8" type="ORF">CU097_001685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000784">
        <property type="protein sequence ID" value="RCH92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS62"/>
    <dbReference type="STRING" id="86630.A0A367JS62"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="177" mass="20688" checksum="D04966A905006C5E" modified="2018-11-07" version="1" fragment="single">MEFPDLGKRCTAPACNLYDFLPYTCIYCKHIFCQEHFKLQDHHCPSLNDPNMDIRVPTCPICEKPVSVPRGQDPNIRMNEHIQNNCADLKPKNDNTCRKKGCTTKMLVPMQCPDCKRSFCVKHRLPVDHLCKGKQIDEKPVKQTNNTSRAEMERQRKDRIEQRKQEIHRLQLKAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JST7</accession>
    <name>A0A367JST7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000763">
        <property type="protein sequence ID" value="RCH92919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JST7"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="366" mass="41871" checksum="D50122FE856B6E34" modified="2018-11-07" version="1">MATVVKEEKDEYYDVDDGGSIGGDSGFSTGEEDKHDGSKATTAVATVQEVTTEQSEQLEDVIDVSRDVRDEQVSVVVQEEMILVDDEEEQKKNFFTRVASIPIIQDSYLGAHSIVRQHAIGQKALDYAETKIQTILVSAQSIDNKPLGTIFSHANDLGNRSLDLLERQFPVINSPTQEIIQPIKGRLDQAISLWKEKGDRASMDRITDQFERLLDYYLPAEQEEKVTIQEHGVQRLVKVINILSSRITQKVVNKVEASKEEERRIRAVIKTWIIEQAKSMIEKRPFLKEKIDIGSEQVQTLYNFTQTELDKVRQELNKQNLSHMERVRSIWTLSRNDIILPLFEKSSSLFYFKRQDQQQSKMAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSU4</accession>
    <name>A0A367JSU4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000751">
        <property type="protein sequence ID" value="RCH93024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSU4"/>
    <dbReference type="STRING" id="86630.A0A367JSU4"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="14002" checksum="0ACB024AE3725658" modified="2018-11-07" version="1">MPTATTTTDEINLHRLLIHCEERLKSQPADAWSALEIAKFATASFERNKTDTPKETKESEIRQRTGGKRDEAFDLEHVLQHHRQIHDELTTDLSRMAEQLKKNSQAFGDTLKNDDRETETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTR6</accession>
    <name>A0A367JTR6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CCA1_1</name>
        <name evidence="8" type="ORF">CU097_012417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000714">
        <property type="protein sequence ID" value="RCH93308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTR6"/>
    <dbReference type="STRING" id="86630.A0A367JTR6"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="215"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="510" mass="57871" checksum="C8D2A6BC520C69E8" modified="2018-11-07" version="1">MSTRVYGVAKNGATMKIELTEVEDKICKVLQGVSELIAQKRPDLPKIESRIAGGWVRDKLLGNECNDLDVAVNDMMGYEFATFVNEHLKNQGVATRNIAKIDSNPEKSKHLETATTKLFDRDVDFCNLRTEAYEPDSRIPSQITFGTPTEDAYRRDITINSLFYNVNTNEVEDFTERGIHDLIYGIIRTPLEPFETFHDDPLRVLRCIRFASRFNFQMTPELCEAAKHPQIKNALIHKISRERIGTEFDKMISGPHPLLALELIQQLELYPIVMKAPEDISSGTVGSDQMAVDAVGAVTWLEQQETALKSSSKAEKRTMFLTASVLPFLGVTVEQKKRFYPGVQSVLRDSIKTNNADIKTVSSIFQGIPVLVELAKENTQRQIKRAELGMVIRELKETWKTAIKCAAIKELLDVYPNAPWTNPKEIQIDNGVCQKYVDLIKRAEEYGITNCYEWKHLINGKRVAEVVGVRPGPDITGLLEVQMKWQLDNPDGTIEECEKMLSEYWANKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTT1</accession>
    <name>A0A367JTT1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000715">
        <property type="protein sequence ID" value="RCH93295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTT1"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="22129" checksum="A1D4B3C9EA0A0FD7" modified="2018-11-07" version="1">MTIPKLALAISSKRHRQMVLGGLGAATLLSSVLGPAVWIAVGGATSVFFWRLYKRAKNWWNYLSPTSSQLATITERLVSSMSSHRATELVREEAIRQLREYFESTDQGKQILEEFGLDHVKDLVWDDVYKSETTRLDKDGKLHQVVINFWLSDETSQGPKGGSCEVTASATVREGGKIHLDSLSMNAPGWHAEEAIPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUQ5</accession>
    <name>A0A367JUQ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000670">
        <property type="protein sequence ID" value="RCH93663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUQ5"/>
    <dbReference type="STRING" id="86630.A0A367JUQ5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="6108" checksum="CF081297A74B7D5A" modified="2018-11-07" version="1">MNNNQGQYYASPPQQGGYYPPPQQGGYYQPAPPPQTIVVQQQPPKEDHSCCWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWG2</accession>
    <name>A0A367JWG2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Arf GTPase arl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARL1</name>
        <name evidence="14" type="ORF">CU097_006304</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000596">
        <property type="protein sequence ID" value="RCH94270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWG2"/>
    <dbReference type="STRING" id="86630.A0A367JWG2"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000510">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH94270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="182" mass="20381" checksum="BBFCE650EDAD6254" modified="2018-11-07" version="1">MGALFSSLFSKLWGEKEVRILILGLDGAGKTTILYRLQIGEVVSTIPTIGFNVETVTYKNIKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSVDKDRMQTSKEELHAMLEEEELKDAALLVFANKQDMEGALSAAEVADALGLSTLKNRQYSIYKTSAVKGEGLTEGLDWLVNIIQENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYA4</accession>
    <name>A0A367JYA4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000524">
        <property type="protein sequence ID" value="RCH94926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYA4"/>
    <dbReference type="STRING" id="86630.A0A367JYA4"/>
    <dbReference type="OrthoDB" id="2283750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="524" mass="56368" checksum="36D303F1CD3037E2" modified="2018-11-07" version="1">MVESTKDNTDGFANKDTQGIQTKIADVKDTSAKDTGVNGAAVDNPSSSKDTSDPFANADPPNTTSSKTSAAPEPTTQPKPEPTTTQPKPEPTTATTTTAAQPKPTTTTQQKPNPTTTNAAVTTTAAPVAPSIASTPSINVAPSVIVPNLSSSSTTAAITEAITSMMSNTAIPSISSTQSIQPSATSSVAPTADNSNNTALIGGIVGAIAGVAAIGAFALLMIRRSRHKAKSTRASRTMDEIFTPNGTTGDGTKNYDAYQGGAAHPSEQGFTVGNLHDYAATASPAVTYVGAYQEPGNQYYNAASHEHYQDAGYAHDAAYAHGQPTNFAPGAAVVAGAAAATYPVTQQEEMYYESKPNEHDAYRHDPNQQQDKVYHGPDQHLYHDNSQQVYQDPNTQMYHDPNAQMYVDPHQQGYYDPNQQAYPDPHQQMYHDPHQQVYHDPNQQMYHDPNYQYQEQYHSPNMSYQQVQPSHNSPTVGNYHLEQPLTSPQPQQQQQTYRLSVDLGHNQQTPSGTFIETHPGKPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ25</accession>
    <name>A0A367JZ25_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000497">
        <property type="protein sequence ID" value="RCH95145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ25"/>
    <dbReference type="STRING" id="86630.A0A367JZ25"/>
    <dbReference type="OrthoDB" id="2289449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="36550" checksum="92A4F40050D1EDE9" modified="2018-11-07" version="1">MNNNTSTFSSAASRPNKIVRLNKSSTYKAVHASSSSTINEVEINDLETQVNAMEIDNNVSSTNTKENHKSYKSSYQTDPAYDKTIDENTFNLVENLSISLNNIMNSYGASRELHRKVVGFVSTVIRDNEKLEQRMIVFFPPDTVDGLMRNTLPIHGHTYDICKNGCKMFKLNDENDDTCNYCGEDQYKPEESLQPVSTMKIISIVGYLSNMLSNEETRSMLLYRSNREAKNNVYQDIFDGDIYKSLKQQNLFDNDLDITLALFVDDYNPEERQKNNENYPLVIPGPRKSKDIDSFLKPIVDELMDLCDFSRHTTSNWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZE3</accession>
    <name>A0A367JZE3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Abasic site processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000484">
        <property type="protein sequence ID" value="RCH95267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZE3"/>
    <dbReference type="STRING" id="86630.A0A367JZE3"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23948" checksum="68BC25B4AD7D3AB6" modified="2018-11-07" version="1">MCGRFACSLNPEQIVERLHKDNYCREDIQVDCQDFRPSYNVAPIHQIVTLYENNNQKSLKTMEWGYVPSWIKKLPINRPINARQETLEQTKGFYVSSKDTHRCVIVAEGFYEWKKPGNGTKKPYYIKRKDGQLMMFAGLYDINELTDKSYTCAIVTTEASKEFSSIHTRMPVILNQDQVNTWIDGSIPWSSRVIDLMKSFEGELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZG6</accession>
    <name>A0A367JZG6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SNRPD1</name>
        <name evidence="13" type="ORF">CU097_014209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000478">
        <property type="protein sequence ID" value="RCH95333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZG6"/>
    <dbReference type="STRING" id="86630.A0A367JZG6"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH95333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="15049" checksum="C7EB3E7247F77412" modified="2018-11-07" version="1">MINVRAVPSTDERKAVYETAGNDCLEFLMKLNNETVSIELKNGTVVHGTITGVDMSMNTHLKTVKMTVKNKDPVSLDSLSVRGNNVRCIILPDSLPLDTLLIDDTPKSKKKKTEDGAGRGRGRGLRGGRGSARGRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZW0</accession>
    <name>A0A367JZW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_010455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000462">
        <property type="protein sequence ID" value="RCH95483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZW0"/>
    <dbReference type="STRING" id="86630.A0A367JZW0"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30348" checksum="F80B39D81A8A0201" modified="2018-11-07" version="1">MSATRHDEYSIQENGPLQPPPLPTHQIMTPSPTPTVKPPNMDLDAEKMSDIQYIDTEKGMKKRRMDNRNGCLRCLCCACCLPAWAAGIVWFIIVAIIIVVIVLGAVAGTFVMPKVDMAGVSTSPAEGGSQISFTGETFNINFGLIISVNNPNLLSIDLTDIKATAYYPNQSGNGRTRVGGGYLAEQFVPKYSNFNFTFPFAIQYNPTLDTDQSVLSDLASKCGLTGEKKQDITVDYTIHLTARVLFIKVHPTIDSSATFACPISANGALDGLGDGTTISGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0B1</accession>
    <name>A0A367K0B1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDE9A_2</name>
        <name evidence="8" type="ORF">CU097_012026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000449">
        <property type="protein sequence ID" value="RCH95610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0B1"/>
    <dbReference type="STRING" id="86630.A0A367K0B1"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="573" mass="65553" checksum="871F2A50AC144BC9" modified="2018-11-07" version="1">MLLLRHNTLSAEDLFTIECKMIKIADQNHKIGNLQHFTVLDKSRAELYGYILGFSERLGLCDSIGVTPSEFLDFLIDVDHGYLPNAYHSFYHAVDVAIVLYQMVCQYDVANYLSRIDLAALFIAGLCHDIGHPGKNNNYQVNLNTELAKRYSNKSVLESYSCTLTMDLLTKHKLLKQLEKTSSLLGLRTTEPEMRTSIIKMILATDMIFHYELQENLANLLELVVDHEEHTCKKKHKPTLPSTAEENEDESDNDDQSPNEPEIKDIFTNQGAKSAIDYFRKKSYFEDSIPLYLKNMPLLPASPEEDEDEEDDEDDEDDEEISGVMNTTIKVKEKTTYTPPNYIMEPQQRLILCQIILHAADISNALRPWPICKSWSNLVCEEFFGQGEAEKAHGLPVSPNMDRDQVSQTTIGLQFGDFVVSPYFEIFAAFFPKADELLKTLADNRKEWLKMEEELAKTVKIEENEGRNERLPSNMLPDDRPIINPTGRRVSVAAGMVIIPDELEERTVGTGKNKRKYWGVRSVSHSEAFEDRKRSEIVRRRKSEEPMRKIKTISPIRKITKKSVTINACSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K115</accession>
    <name>A0A367K115_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CLP1_2</name>
        <name evidence="8" type="synonym">CLP1</name>
        <name evidence="12" type="ORF">CU097_011964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000424">
        <property type="protein sequence ID" value="RCH95876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K115"/>
    <dbReference type="STRING" id="86630.A0A367K115"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.330:FF:000002">
        <property type="entry name" value="Protein CLP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="118"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="324"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH95876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="438" mass="48649" checksum="6B288925DFDF165D" modified="2018-11-07" version="1">MQENEGSDTPREVSLGPDHEFRFEVDFNKKATVKLTKGTAEIFGTELAIGVEYTFSGRKAAVYTWHGCTLEVKGQFSVEYTANETPMTSYLNTHLALEQLRQKMKKEKELGPRVLVIGPHDVGKTSLCKILMSYSLRQGGTPIYVSLDTSEGSITMPGAVTATCINHIIDVEEGFGSSATTAASMGSATTPLVYYYGFESPAENVKLYKLVLSKLAEAVKSRMAVDEECRTSGIIIDTSGLVDQIGYETIQHTIEEFSVNVVIVLGHERLYSDMNKLLSNRNPNISIIKLAKSGGVVERDREYKSMLQRTKIHEYFYGTPKCELLPYSMLVNYDDIKIWRVGDVIAPSSALPLGMEGSSNETQIVKVDSYDMCLHSILAILNAPPDEHENKLLESNTVGFIYVSDVNDEKRKLTILSPSPGRLPKKHLLMGVFKWMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1J8</accession>
    <name>A0A367K1J8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000403">
        <property type="protein sequence ID" value="RCH96083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1J8"/>
    <dbReference type="STRING" id="86630.A0A367K1J8"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000008">
        <property type="entry name" value="GRAM domain containing 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="420"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="795" mass="89283" checksum="CFE053AC16AC7EBC" modified="2018-11-07" version="1">MDSLNVNDTTASKRRSHSNTVSGARPPALDISLVRPPNIRRNSEGSPNVPPIQVSEPTPIEPSVNVQHDFFKEGEISRASSPNQMSSTTDHSPQSGPKVNNSSAISLLESATAPKKKSRSRASSLTSNLINEIKENPTIQKVSTTLAQKIKPRQNSDNTNGDRSSIDGGNSYTAPSSASTYDLASVKRNQDFHSLFRSVPEDDSLIEDYGCALQKEILLQGRIYVSENHLCFNANIFGWVTNLVIAFADITNIEKKSTAYFIPNAIQISTESAKYFFASFLSRDQAYDLMVEIWHNCRPDLFPPKEDDIDECDEEEESEPAEDDDSDYDSDTSSQGDDIEPEDTNKQSTVQTTTKDVNGSESNTNHQDSPETASSTAQSNKASEKTAKGSQVSVNGTKKANEEPSNQLHEKTKCGCQEHYPNTVLDMTYRGSLEKIYKALFHSDFLETFLVDNQKSTELSMGDWKPGEGDVKSVRELSYIKPLNNSLGPKSTKCYLTQEILHEDFDNYVTALITTNTPDVPSGSAFCCKTRTCFTWAGKQKVRVMVTVAVEFSKSSWLKSTIEKASIEGQQTYYKDLDAALRTYFKEHPSEFGAYEEKTERKKRQKGKRRRSAKATVQQEDKDTVSRPETKGFMGNLISHITRVTQSASASHFMIFCLVLMVITNMFIARKMSFIEKQLDEICNIIPRHGRASQSNEQVSMMQKQSYDTKEQQELWEWLSRLDPEKTASEEPILLATHTSEGKENEWDDAIYLSKSTKDRLDKHISEISNLIHEAEKNLKVVTESVNFQRQKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1P4</accession>
    <name>A0A367K1P4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell division control protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000396">
        <property type="protein sequence ID" value="RCH96162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1P4"/>
    <dbReference type="STRING" id="86630.A0A367K1P4"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="577"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="742"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="114334" checksum="24EBED1C388BE879" modified="2018-11-07" version="1">MTAPSILCKVRALYAFESDDPSSLRFNEGDYINVFYKLPSGWWDGWCNGQRGWFPSNYVEVIEDYCDTDFNSTALHQDELLQKDCNYYSNNQLQQFPVYYEEGSASTIERSTSANDLTDMRHKRWCMSLPAYSPWQQQEMTQREKLLNRPLSLSIDYNELISYKKLLVDITLAINNLVTAARSSQSYNIYTTQVVNTVRNMMLATGTASKESINIKSDSLLRSHHRHLMSILSRLIFSAQTGEATRLFIESQDLLSTARNYVHLCESMGIELQHIDPILLSDWSYRRQNSIQSKYQLVPDLIDNVIACGNGMQESMKSFIAHLGCSSDTNSLIVLLFTHYRNIVNQNGQFLSIIEDVDFQYVAHSPRMKELAYSKQRLYTALGTLFIKIQSMTEDGDECITENMRQTAHSIIEAIQTICKVISELLAEQSNVTHIDEGSSSNQVKTNGNNLMLLSDTSSHSSSRSSLIEPASSEQKPHAVDLFHDYSLDNQMSLRSSDTLKHFSLEDKGALDITPPNEDDEEPPVYKANEHDNDNNMTSRKVSILTATTQSSRTATVESEPEYLRYDYAPSEIVFTTDGSVKGGTLRALVERMTLHDYLDMNFNTTFLLTYRSFCTSREFLDLLKARYNIQPPDGLTPEEYEVWVNKKQKLVRLRVFNVLKIWLEQYYYEDDSIILDQLLEFTNTTLKNTLSFSAFQLEKLISKRKEACTTSLKKLVMTQSINVPDPILPRNLKKFKLPDIDTTEMARQLTLIDYKLYSSIRPIECLDKAWSKDLQENGVPIAANIQASIHYCNQITTWVSDEILSQSEVKKRSMQIKYWVNVAEKCRQFNNFNTCMAILSAFDNGAIGRLKRTWESVGARTHHIVAHIRKLMGANRNFVQYRALIHSVNPPCIPFLGIYLQDLTFIEDGNPNFLKGSNLINFAKRAKTAEVIREIQQYQSIGYPFKPVEEIQGFIWENLHSSRDEDQLYNESLKLEPKERGDEKITRLLQESGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2K7</accession>
    <name>A0A367K2K7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_004835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000363">
        <property type="protein sequence ID" value="RCH96492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2K7"/>
    <dbReference type="STRING" id="86630.A0A367K2K7"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023269">
        <property type="entry name" value="RCMT_subfamily_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02010">
        <property type="entry name" value="RCMT9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="15">
        <location>
            <begin position="219"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH96492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="562" mass="63963" checksum="192C05C4192C986F" modified="2018-11-07" version="1">MARYAVICASNQNRSMEAHHVLQKKGFNVNSYGTGTMVRLPGPSIDKPNIYPFGTPYEQVYQELKSKDPNLYTQNGLLNMLDRNRKTKPAPQRWHESREVFDVIITCEERCFDAVVEDLVNRGQNLNQSTHVINVEIKDNHEDALLGGRAILQLAQMIEASTDIDADMDGIIEEFTLRNPSFPILHTLDDEEVPSSSTFDLSQLPSSFKKFLDDNSIDPAIYTVVDLPRYFRINTGLPKEKWPTLEGLREQFKTDQVQEIKGIKGFFSVKLDNVRLSDTQAYKESAIFGIDVSSAIAVEALSITQDDQVLDLCCAPGAKLCMISNLFGKEGVGTVTGVDIAEHRLSTCRSLLKRYRVGERVRLFKADGTRFSILPPSRIGNRVIHEEHDSKRQKTEIVKPFWAPKTLRYDRQINHGVLYDKVLVDAECTHDGSIAHILKYEKWGWDSFEKNFMDSNRLSSITELQRNLMKQGWRMLKKGGIMVYSTCSLTISQNEENTAWFLTEHPDAQIEKIPNYDIQPSPIKKQNINDKLQGALEEHCVRFDPISSCTSGFFLVKFVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3X4</accession>
    <name>A0A367K3X4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000332">
        <property type="protein sequence ID" value="RCH96846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3X4"/>
    <dbReference type="STRING" id="86630.A0A367K3X4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="34285" checksum="80855261E3BDC5EF" modified="2018-11-07" version="1">MSNQSSIINRFSAINSSPSIVSSPSTSEKQHIHSHQSNSFFLPKDWESKNYDYNLHFALKTIFGGNVTPAVAPRLQKGAVIVQMGSCTGPWMMDLATQYPDCRFFGIELIPNSFLQDFPPLPNVTFERGLPYNEIFEKFKDNSVDYVHLRTCSGYLDVTRWTLLIQDIFRALKPGGVIRVEDIHNQPSGTVMIESFIETIRNISAANNFDYDIMAKMGTILTQQNFQVIETKKKTIHYGSGGRLAEEFLLFVLNSFEQAGDQLGPMLGLDTEDYKHRVEMFCAQCVKNDASMDWYSYVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K417</accession>
    <name>A0A367K417_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000328">
        <property type="protein sequence ID" value="RCH96886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K417"/>
    <dbReference type="STRING" id="86630.A0A367K417"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12078" checksum="D9B8005A8DCE9191" modified="2018-11-07" version="1">MSDIEEYQPLFGQKKNKRSTLQKYGYYIATGVVLFTASLFLGHFVYESNVQLDSPVEFVGHIAKGTKGAVAVEAEQCSNIGVEILKKGGNAVDAAIASTLCIGVIDTFATGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4C0</accession>
    <name>A0A367K4C0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000317">
        <property type="protein sequence ID" value="RCH96999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4C0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016662551" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="79" mass="8697" checksum="2713610C80B120C0" modified="2018-11-07" version="1">MLPSFYIALVVCFISLLASKVASASHLDDSRGYLLKRIIFLPPLPPLPPLPPLPSLQPPGVAVGRLSYKKYSKYNDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4F4</accession>
    <name>A0A367K4F4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000304">
        <property type="protein sequence ID" value="RCH97142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4F4"/>
    <dbReference type="OrthoDB" id="273230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="200" mass="22774" checksum="BBF1842549B7507A" modified="2018-11-07" version="1">MSQNTTPTTNATAKTLSSSKTFPRRIRSASARLFSSTKSNPALHKRYSCYFNSESNQQHISILNPSTWFPKIRCRSSSTSSSFSLAYSPSSEHYSPKHQHYSEPHASNLESLSSELEELYNNAKIEIDFATESFGSIYYEGDYSTAHSSFESCLSKYQSAMQTFGDTANSIKFRFRWETDIHQLRLRLDALPEVTHSIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6E4</accession>
    <name>A0A367K6E4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000280">
        <property type="protein sequence ID" value="RCH97411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6E4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="96" mass="11135" checksum="326C8B389EB80CE3" modified="2018-11-07" version="1">MFSYPTTEKAEVLPPYANLTPTYNKDHWRLVKVPPLATGDNNNNNTYPLLSMVEQQQINFYTKPPAFIPPQQFIQQQQQQQKMTPPVGQGFVQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6Z5</accession>
    <name>A0A367K6Z5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein phosphatase PP2A regulatory subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAB1_7</name>
        <name evidence="9" type="ORF">CU097_008804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000238">
        <property type="protein sequence ID" value="RCH97909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6Z5"/>
    <dbReference type="STRING" id="86630.A0A367K6Z5"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000651">
        <property type="entry name" value="Poly(A) binding protein cytoplasmic 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="126"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="220"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="317"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH97909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="412" mass="46544" checksum="D84CE41C92270367" modified="2018-11-07" version="1">MTMTDTSLGPKGLTIEQQKEIAEMQAKSVNERYKPRITTQTSLYIGELAPDIDEEKLKAHFDNVKHVQIYRDSVSNENLGYARIDFYTHKDCSAAFENLNNSKIDGIDYRLMISDRDTAKRVSGTGNIIIKNLHPGVDNKSLYDTFSRWGNVTSCRVINKLTGGTVKGYGYVNYDTYAAAERAVALVNGKMLFGIEVHATHQIPKHERELTSTHNENRFTNVYVKNLSIDVTEQDLNQLFSTMGSVSSILIQRDDQQKSKGFGFVNFELPDDAERAVNELHDTEFFGKKLFVTRAQKRSEREDELKRHSSTSRHTGVNLYIKNLADNVTDEMLVERFSTFGTITSAKIMREEKTGASKGFGFVCFSSSEEASKAVTGMNGQSICSKSIYVALAQRKEDRRHFLETQISQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8S3</accession>
    <name>A0A367K8S3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000212">
        <property type="protein sequence ID" value="RCH98241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8S3"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="504" mass="57094" checksum="AC7F0576A61683CD" modified="2018-11-07" version="1">MMTSGPDALLISDFNQKAIDSIEYARSNKHAVFSSIFDMSEITNTCDSYKLKFAYNIQILPGSGQEKKKDDLIKINSQTTGVFNTTDCLIDGANDFTFSGTDNGLINLSRSVPFTSQQFQFHIQLYNRYHVLQEPDVDIKDEETTFLNLLQSKTINANEIDINYMHRKNRKHLGRLKKKTSQGEEVSTLEAKLEKASLSASSNVEEFQQNYHVHEDYYEASRSRKKKYLDKIIAQERESLTKANTGSDKKQLHGKHVNVCITNEHMTSQTCIYCYQKLCHPKAMLTKKNKQVSQEIKGALMCVNPKCMAVKSGRSTKSRDALSSLAIGLSGLAQCLIGSPLPPFAQFQISQFNTDTVNKLSWSFVSARDHLTSTLPPRSLPILTLFHNVKSDNSRAALRLLQSRQKNADGEEKYRIDVMDEYKQPITDTQLRQVASYLGSKTPWKDMLLPEASQIIDNAQDAFKIIKDKPEVLRCPIVVDWERGRAASGIKGLEDIERLINERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA88</accession>
    <name>A0A367KA88_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000150">
        <property type="protein sequence ID" value="RCH99060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA88"/>
    <dbReference type="STRING" id="86630.A0A367KA88"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="54"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="54"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="382" mass="43391" checksum="25F96D41D62A388D" modified="2018-11-07" version="1">MNTMQQSKEWQHQHQQQQQPLPMTQQTPMENTKSGPSSSPKPESDHYGYLRQLNNNSSNRYEQTIMAHSQPSTPHPYPMTQMIKSTRSHFNTQECSPKFLPTKSMANLLLSDKSTLSPIQIQAKMDRGFFLADGEWTCYRRNYFQVSAVFSLASYPEVYYVQTHRGPQYVQRFLIGLSARVANSDRDIELVQQTPKRDKGPQYKPAPKPVIPGGYLSPGNSQHEAHPQQNIATFERLQFKSATANNGKRRAAQQYFVCVLSLYAETKDQQELIQIASCQSVPLVVRGRSPGHYADTAKTSSSPVTPVMQVNDSYYYYHPVPYYSCEESPSNTKLPYEPYDWQRARYNSTSSSGSSSATSPHQPSQESYFPAPPHPLANVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAH2</accession>
    <name>A0A367KAH2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000139">
        <property type="protein sequence ID" value="RCH99214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAH2"/>
    <dbReference type="STRING" id="86630.A0A367KAH2"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="58"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="289" mass="33189" checksum="A836BC2DE47F715C" modified="2018-11-07" version="1" fragment="single">QLGPILANDYSKLTVSVKDPLLYGSIQQYLMRTEHNDAISTRAFLLQKDSVDDFGPNTLQLKDNWRMNDEMNRFFKLIYGPDLISRNPERKLKLREKDMKDDLLRSILDPSRAISLVNVQVPVYLISQMQEVEANIVCKLVDAYLGSLKESSMPVRQDAPKVMVIAPYVKQCVAIKRRLNHISDKILVGTVDKMQGQESDLIIACYVCKLNDYRNDFLVDFRRWNVTLSRAKCKVVVLAIDNLFEQNVHKQIVKSLGSSNFEPVDGLALLCLLKEWTTQRKSSHVWVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBB3</accession>
    <name>A0A367KBB3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">WDR43_4</name>
        <name evidence="6" type="ORF">CU097_014396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000122">
        <property type="protein sequence ID" value="RCH99457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBB3"/>
    <dbReference type="STRING" id="86630.A0A367KBB3"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="250" mass="29205" checksum="9AD7C939ABA5A672" modified="2018-11-07" version="1">MAKKGDKNNRRSSIVEDMKKSETIEIANGEVDHSKFSVIRQGNEYNVPKEIKHWNELKQECTTAEEIHNTVRRLPLDNVLPLLQELLEKFDVQQARDTELTEWIKAVLLTHTAYFMSLPEIVQQLSDLYNELNVRLTVYPKLLAMHGRLGLIQRQIDYRNRKEEDESEDEDEEDVKVFSESEDEDAEDDAVAYGDEEDDEDNDDLMDIDDSHGHDNNNDEETMFAEEEEDYLNTEDEEDEEDLSESEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCB7</accession>
    <name>A0A367KCB7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000093">
        <property type="protein sequence ID" value="RCH99893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCB7"/>
    <dbReference type="STRING" id="86630.A0A367KCB7"/>
    <dbReference type="OrthoDB" id="5514950at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="33241" checksum="225983C9623B8AED" modified="2018-11-07" version="1" fragment="single">PSFAYLDVHFSPQGKIVTDLLIRKNTASAISAMRATLLSIGVPSSSFSRLIASCLYATFIRPKFEYGLCICTFLVKQLALLEKAQDHCLCMAFGGHRASSISVFKHLVNLSSMTERSNILVFKFILRVHFLPEDTLLSLLLRFVQDAPAYVFYPTCRAVGLLLYNDYIPTVTSILTKAGIAQLSVFNPRDEASLCDPKHAQLPPDGRTAMITSIHTIYTLRALKRIRSEVRPAVLRAFIECNWLPATQYADYTNELAANNNSQPSALVNTEMSDIPTAPPSTLALPSPTGDGQPVEGQLCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCW8</accession>
    <name>A0A367KCW8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000108">
        <property type="protein sequence ID" value="RCH99661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCW8"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="17534" checksum="249C407746D5574B" modified="2018-11-07" version="1">MSEDFQPYRLDTEYTEEIEQLIELQRRHTETRKAHIENIIVDEDDDSFSVHEKHPRLNAPPVPDFRYEQQVEKTIKSLRDKGTSPIGIFWTVVIQDQIILPFVSGFAWCICSNAWKWYRTRGVVNKQTPKRTMGFLRGLQHGITEWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCY0</accession>
    <name>A0A367KCY0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000084">
        <property type="protein sequence ID" value="RCI00037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCY0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="131" mass="14625" checksum="6141D85C2439445B" modified="2018-11-07" version="1">MSSYTSRFTELDIYSSEFVLREIATTNSSTQSSSIYCNPYFANSDPILQGKSSSSLAKHYLTIPENSRPIDFSADQRSTLPLPPPCSSSQPNSTEKHFQSLAKRFKRFLHSISTPRPKSSFSSSSSYSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD41</accession>
    <name>A0A367KD41_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein tssc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSSC1</name>
        <name evidence="6" type="ORF">CU097_015461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000081">
        <property type="protein sequence ID" value="RCI00097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD41"/>
    <dbReference type="STRING" id="86630.A0A367KD41"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="5">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="360" mass="39994" checksum="1E51482EA5B06513" modified="2018-11-07" version="1">MENSNVFGLRHQARCLTSVKKSTEKSKFLAGTVGAKENIVCLLEYDDDNALLSSFMFQHPQEVWDIASCPNDEDVFFTCHSSACESPLKSKATLWRKPSVSIENQQQELIPLMTLDYEGAKKVVWSNEGGNQQAACIDSTRIHLFSTENAKTLRTIDASSMFSADSDAPSLKLLQNAVWNPHDPQVVAVGGSCVAGWDIRSGQNNFKISNAHQSTVRAVDYNPNKRYHLATGSDDALVHLWDVRQLEKPLMTLEGNSHWIWSVAFNPLQDQLLLASGSDGLVHLHNVYSISSAATMEEEEEEIGRKPSDGLICTYDQHEDSIYSAVWSFADTWTFASISYAGRVVISQVPSEEKFKILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDC8</accession>
    <name>A0A367KDC8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MGE1_2</name>
        <name evidence="7" type="ORF">CU097_015649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000075">
        <property type="protein sequence ID" value="RCI00198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDC8"/>
    <dbReference type="STRING" id="86630.A0A367KDC8"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="27213" checksum="2C3E3FAA1F628CC9" modified="2018-11-07" version="1">MLSTSIFRNAAALSVKRTVSARLAISAPMTARRAYATESGEGKTEQTANEESKNDQVPKEEETKVQGELSEEAKKLLAEKDKKISELQDAYLRCLADQENLRERSRREIETTKEFAIQKFAKDLLDTVDILNMALNAVPTELRSKSTSLESEFAKDNEKLIDQLTNLYTGVSMTEAELIKALKRHGVERVNPEGEAFDPNQHQALFQAPIPGKEAGTIFSVQKMGYTLKGRIIRPAQVGVVADAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDG7</accession>
    <name>A0A367KDG7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000069">
        <property type="protein sequence ID" value="RCI00283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDG7"/>
    <dbReference type="OrthoDB" id="2247533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="116" mass="13147" checksum="3C01F8FDB1AFAEA0" modified="2018-11-07" version="1">MNGHNDKTNVDLNYATIVTNLSKGQLDSLNVEDFIEQENINLGQHQKFYQKQQQPNEVHLSNIDESNTLFVVNSFMSLTETIPDTKQTCTESIEKINAAMSIVNQTIQSIENAQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDQ4</accession>
    <name>A0A367KDQ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000088">
        <property type="protein sequence ID" value="RCH99971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDQ4"/>
    <dbReference type="OrthoDB" id="2240884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="191" mass="23024" checksum="7097300A0BC76223" modified="2018-11-07" version="1">MKSVRFYYRKKFDDQYTFELESNLTIHEFHAIMALFNQVAKRYPPPTSRMYYMMGLFMLWMVAFTVFYYVWIKFHASYILLGLPVFMLLTSFILGWVSKRRMIKFENEILQVCSRLNATENIRGINFRFTRDGLDITHCRYFYKPNYAIDIEMDERFTALNQFHQSNISVPTTAFTVNEKQALNMFDYINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEF9</accession>
    <name>A0A367KEF9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000057">
        <property type="protein sequence ID" value="RCI00500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEF9"/>
    <dbReference type="STRING" id="86630.A0A367KEF9"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="183" mass="21053" checksum="A2D91AD3CD4E822E" modified="2018-11-07" version="1">MENKTGIKITFNFTEQHEGIDDNYMDGTYLSSFDFSNNQTLLSPRIPKQEPAIVGRPVEATPDAHEPDYPIPEQMNKNDDMIVAVFEISNRVDNVESLLTGPSQHNMQNAEYLSLISDATLTICTLIGRRIMIEGYNEESVNDALSRFERLQTTYVYWMLYEAYDCSMPSLFMRIRFLPTVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEU3</accession>
    <name>A0A367KEU3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_015361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000049">
        <property type="protein sequence ID" value="RCI00630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEU3"/>
    <dbReference type="STRING" id="86630.A0A367KEU3"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="283"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="416" mass="47640" checksum="7564C00EABF4FE67" modified="2018-11-07" version="1">MGVACCKEEPVDLLGEVELSHFLLLRSVGKGSFGKVRVVQHKGTKKLYALKYINKEKCIQMKAVDNIISERRLLERIDYNLIVNMRYAFQDDENLFMVLDLMLGGDLRFHLERLGTLPEDYVRFYAAELALSLNYLHSKQIIHRDIKPDNILLDEKGHAHLTDFNIAAQLGNKKNKSLTSIAGSMAYIAPEILKKQGYSYSVDWWSLGILLYELLYGKRPFQGKSNEELQRSILHDPIEFPKEPKVSQEAISFIKELLTRDVSRRMGVNEVGFKRLKNHAWVSGMCWDILHSKTVGAPFIPDENKSNFDPTHELEEVLLEENPLKVKKRTALPKKSMSNDELAMIAAEDSYYAEKIRLEQSFKTFDYTKPDCKLQILTDSCTIPKEEKDMSEESSTLLGDSDIAIDKPKHAHVLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF37</accession>
    <name>A0A367KF37_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_015754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000060">
        <property type="protein sequence ID" value="RCI00442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF37"/>
    <dbReference type="STRING" id="86630.A0A367KF37"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="191"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="86652" checksum="01718DE52CCCAD66" modified="2018-11-07" version="1">MLDIQKTDTAWHTTSHNTVPPELLHSLRHHSLFQRANNESFLEKIACRMHLRTYGPRDVIVVEGEPAKAMFFLLRGSVDVCSADFERIYANLSQGSCFGEIGILYSMPRTATVIARTKCIVASLTAEEVNNLLPRYPEVERMLRFEAEERLAVLNKSKNLGVKEKVSLKPMTERNIEDFTGIRQLLQKIPFFQGCPEEFLHLISLKVEPRHYAPNAIIISKGEYGSELIFIISGTVELTNTDDSGILVPITRLSPGDYFGAISVLLNTPRATNARAVTALELYILKKSDFMDVVHHFPDLLGRFKAMAEISLSHLQSMTGVYQMRAVEEAIDTPISPRANHEQLSPEGLSSLTIPTNSVCSTTADQDPTLLPPTPTSNLKKSETRRRRASVAVWSDPNLVALANRHIKPDKHETQQTKMTTESTQPQPKISQPVIKGQLSLFTEDILSRIVNCLDFTSILQLSMVSKQCREFIQQNNNVLKSLDWSSMHKKITDSNVNHLVQFTGSRVRSLNLSQCFYLTDDGFKVLVENLPSVEAMDLSSCWLLTDKSLALLGTACPQLTRLNLSNCRKISDTGIFRLLDAKASNAYPMLEELSVSYCKKLSDTTMRHLASYCSNTLQLLNLQRCTRITDIGFLAWTSTHFPQLQELNLNDCSFLTDQAIGYLISATPNLKRLSLSFCCALSDSAIERLATLKQLEYLDVSFCGAAVSDVSVRTLLASQSIGSLNIRGCVRVTDTTIYSILELGQLRMLNISQCPGISPNAKEAIKAPAKLQELIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF52</accession>
    <name>A0A367KF52_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000037">
        <property type="protein sequence ID" value="RCI00855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF52"/>
    <dbReference type="STRING" id="86630.A0A367KF52"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42047" checksum="3080FED3258F1D91" modified="2018-11-07" version="1">MGQYELLYAHDFKKDSFKMIELATPELMEAFESGNSVVIKGLEEDDAVLCTESKTFAIRQINTSNSLLLVNQANDKLFVKDNLSNTIELQPCLAKLGRIDELLSKICYEGETKEAEIMRSGPLYTLEDLTSIVQASPVELRRGLEERGVFEYNGYCRIFEKTWLSHLFDALLTNAVFHGLDLNQMTMEQAKQCILEEKEAIDEDVNIPDEIIKAALNLFANEVDGRLKFDDAKVCRFLGEWLLCNPRDKRWLLDEFLQMWKTLGHNLFEPKLEYLCGLFIMYENVKMQQIERYIQYFPISELSTDPAKRFSALFAAKPLWTTEDIEPFLNDLAPTKKEREALLLKYTRTHRTKDTVLYASRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG99</accession>
    <name>A0A367KG99_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000021">
        <property type="protein sequence ID" value="RCI01198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG99"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="88" mass="9917" checksum="37EF945EB5428AA4" modified="2018-11-07" version="1">MPSKVVLSGNRNKYYVICKDGMVDKWKQNKSMSIDDVVCDKKIYASSGADPQDYEASYDNPDFRETFGSVKFEDAACKILEKGQQTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJW5</accession>
    <name>A0A367IJW5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005507">
        <property type="protein sequence ID" value="RCH77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJW5"/>
    <dbReference type="STRING" id="86630.A0A367IJW5"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="111" mass="12423" checksum="116ACEE13AA66C30" modified="2018-11-07" version="1" fragment="single">MTTGLDPLPSPTASSLLPPHHDSTSLLPLPPPPTGSTPTKRRSKVPNTDRRNTDIEFATEIGQGLLLEVRKMQALLQEKEEKLRTLENQKADLERAAEAMAKQMRQREENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMH0</accession>
    <name>A0A367IMH0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004859">
        <property type="protein sequence ID" value="RCH78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMH0"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="178" mass="20685" checksum="59C470F03D49D81D" modified="2018-11-07" version="1" fragment="single">MPSYAAFSIERTIQEYKTRIKSRKDPFTNSGNVLVELASSRWIERTALFGNEDKSKAGEVLLDDDEENEYEVWEPINRVELRNNEEVLDFDCFPYLKAYFDIQSRDSNNALDAESIVKFGSRLWSPDGAVFGCSVNHKRDNRTSFFIKLCLKVNTNKQRGLKIDIRELTYFSEAIVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRB5</accession>
    <name>A0A367IRB5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pectin methylesterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01004024">
        <property type="protein sequence ID" value="RCH80240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRB5"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF57">
        <property type="entry name" value="PECTINESTERASE 53-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH80240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="102" mass="11530" checksum="54547E826DFA2502" modified="2018-11-07" version="1">MAFTSPAQFPDTCFFARPWGKYSRVIIMNSDIGSYIKPAGWSGWSDASPNTANVVYGEYKNFGARPWTNARARFAKNLSDSQVAQYSAKKIFNGDVTWFKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRH4</accession>
    <name>A0A367IRH4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_001349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004104">
        <property type="protein sequence ID" value="RCH80091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRH4"/>
    <dbReference type="STRING" id="86630.A0A367IRH4"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="103"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH80091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="37673" checksum="895F47737BD72C27" modified="2018-11-07" version="1" fragment="single">MSQQIPINITNLHPEQRPTYLSNSFRSFVSSYSRASMMHMAENVVLSDGGLSDDEEDGRSIYSSRPHSITTAQEAHEQSPLLHKTSTNHSIMTVADSYHTSSKKSTFMQSVFNSINILLGVGILALPLGFKSAGWVIGLGIFVFCFCLTNYTAKILIKCLDLNPEAKTYGDIGAYTFGMRGRVFISILFLTELITCSIALVVLLTDGIASLFPGYDLIWLRLVSFIILTPTLLLPVRYLSYTSLLGILSVFSLLLVILYDGFTKTDAPGSLREPADTSVLPNNWFDVPLSFGLIMAGFAGHAVFPTIYHDMDHPKEYRKMVNVTYLTTSIIYLTVAAAGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISR4</accession>
    <name>A0A367ISR4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003773">
        <property type="protein sequence ID" value="RCH80718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISR4"/>
    <dbReference type="STRING" id="86630.A0A367ISR4"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="76"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="311" mass="34670" checksum="8E1595B1F6D8B3A9" modified="2018-11-07" version="1" fragment="single">NEPVVRGYVTNTESSSQDTPSAHTQRTAIFLRSSRKIILTGSETEEEARAAENVPIRISKQITFNDVHTQRVHMKQKLAAGFRLLAKFGWDEGVAGHMTLRDPEYPDLFWVNAFGQYFGHIKASDLVLVDHSGAIVRGNRTVNKAAFVIHEAVHRARPDVTCAVHTHSMYGKTFSTFGRKLLPISQDACAFYNTHGVYDDFGGIVYDKEEGERLVNAMGPTNKALILKNHGILTVGKTVDEAIWWFVCMERCCQSQLLAEAASPDGYKGLPLISDQVAEQTVKVLGDSLTGYAMFQPMYEMIIKEQPDCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT25</accession>
    <name>A0A367IT25_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003736">
        <property type="protein sequence ID" value="RCH80786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT25"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="51" mass="5884" checksum="3F475883584AFE48" modified="2018-11-07" version="1" fragment="single">MSNIDQLKFWLEEEPAGREDDVYLPPDTPTVNPGPNTLSLIHKKKTLLKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITN9</accession>
    <name>A0A367ITN9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003599">
        <property type="protein sequence ID" value="RCH81060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITN9"/>
    <dbReference type="OrthoDB" id="2341448at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="68" mass="7532" checksum="635EACCA16C57E18" modified="2018-11-07" version="1" fragment="single">LKWLTFKTTMVILFIALFVAIYYGFHGLLADSVLMDKDRVAAKDNIQNVLQKSAARRAAAATGDKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITY1</accession>
    <name>A0A367ITY1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003559">
        <property type="protein sequence ID" value="RCH81154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITY1"/>
    <dbReference type="OrthoDB" id="5600564at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46191" checksum="B285983282C6D00D" modified="2018-11-07" version="1" fragment="single">TPEPRMSEVEEEENDLATKTAQPPSTAASRRLRSATSHSGLRPIIINAHQFQQGKQRPLSFVDSCMDDYTTTRKPICDSSDTYSPISRKIANYRLHKRLSEHDLYNTDTSSESTQGGDIIKRIDSAKSIDSNVATDAKCEHLKKMLEKEKAIVRALQKQKEAINKDVTFLSQSVEELTAQNSELKKKLDHEKTMKERFQDDLSSTMDKLNDATEYIRRHSRSSIDAGKTSDKSLAVQLRHSQNQVRLLKSTMEQFLRMGVFSDDPNLSSTLSPTVSLDLVVPDFKVKQRQQRQAPSVNNKAPSKKISEVTGKTAKESETASAANQEKPEKKTNEATEKKNESNGSGADLDLQLRALQREKEILQAEYSKAPSSGGNAIVRRRREEIESRLDSIDSQICRIKLKIRSRQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU78</accession>
    <name>A0A367IU78_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003532">
        <property type="protein sequence ID" value="RCH81212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU78"/>
    <dbReference type="OrthoDB" id="10529792at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11018" checksum="368C08A34AE38A3F" modified="2018-11-07" version="1">MANIENEMPTTKSALYPSSHPDESELNFYGRLAAILELVLDCTDVMLVDGEHSCEATKNVAHLNKVMFNPMQNAPPYGKKTGLMLRYDGNIEIELSSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUA7</accession>
    <name>A0A367IUA7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin-like protein Klp8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KLP8_4</name>
        <name evidence="3" type="ORF">CU097_005919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003520">
        <property type="protein sequence ID" value="RCH81242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUA7"/>
    <dbReference type="STRING" id="86630.A0A367IUA7"/>
    <dbReference type="OrthoDB" id="2280331at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="52" mass="5694" checksum="138EA186F16F9214" modified="2018-11-07" version="1" fragment="single">MTGGGNIKVVVRCRPLNSREIARGATCLIRMEGNQTIITKPPDHKGSRDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXV6</accession>
    <name>A0A367IXV6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI transamidase component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_001606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002981">
        <property type="protein sequence ID" value="RCH82535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXV6"/>
    <dbReference type="STRING" id="86630.A0A367IXV6"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH82535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45396" checksum="4DEFBAC47B1F3DEF" modified="2018-11-07" version="1">MLKLLYGTGFLIRIALFNFPSVIDTLSQRVELSTPVTSFKRLTEGVFLYNNNIPPYDGGVFHQSPLLLCLFSFITTFAPFIVPVLYATIDVIIAYALSIITTIKQQQPEPKLSIEKTSISPSTVAALYLFNPFTILNCVSKSTLIFTNLSIILAVLSALRGNMKPSMFWASVSAYLSFYPAMLLPALLLFFNNKKTAAVGSFTGWMIILFGLSRLFIGSWDFIRSTYGTILFLTDLTPNVGLFWYFFIEMFDQFRSFFMMVFQFHAFIFTVPICIKFQHKPLFAITFLCGIMAIFKSYPSIGDASLYLALVPIHDEILKYCRHKFLIFNLFAYASVLSPIFWHLWIYAGSGNANFFYAITLVYNLGQVYLLIELAWAMLRRDFDIEHPEDIGKPVIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXW5</accession>
    <name>A0A367IXW5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003011">
        <property type="protein sequence ID" value="RCH82449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXW5"/>
    <dbReference type="STRING" id="86630.A0A367IXW5"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="51"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="297" mass="33710" checksum="46F3D62089759DB0" modified="2018-11-07" version="1" fragment="single">LFKSLMNPFWRPPNLVIHPNITYATSEELRDALDNSNQDFDQPRKLMLDVITSNKKSTKPRPVLIHVHGGAWRGGRKDIFYPYEKLLVSEDDWIIVNIGYRLAPKSAYPNHLIDVKRAIRWTRQNIASFGGDPDFIVFSGDSAGAHLAAMASLTANDPQYQPGFEQVDTSCRGVVSVNGVLDLTYSNMINYFSKQVAMLSDVNMDFLNKHSPTTVIQQTKDCVPYLVLAGQRDALVNSDVSVKFKKQFDEARHKNPCTLVLFPGGRHISYIAWSPRSLYAARIIQTWCRQLHNDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY49</accession>
    <name>A0A367IY49_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001734</name>
        <name evidence="2" type="ORF">CU097_007202</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002956">
        <property type="protein sequence ID" value="RCH82607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01002956">
        <property type="protein sequence ID" value="RCH82608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY49"/>
    <dbReference type="STRING" id="86630.A0A367IY49"/>
    <dbReference type="OrthoDB" id="2248528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="13022" checksum="A552CAFDC85BE6AD" modified="2018-11-07" version="1">MGCTNYRPIIEFYPESEAEDMDLGYEYGEITTLTDFIAPVHNIKMDENLEEITTNLAVVSLSDDKKKKDKYGPEQIRRSIEILQEEGVSIPVATKICMILIFTTPMAEIVPRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZL8</accession>
    <name>A0A367IZL8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box protein J2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FOXJ2</name>
        <name evidence="9" type="ORF">CU097_005821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002763">
        <property type="protein sequence ID" value="RCH83135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZL8"/>
    <dbReference type="STRING" id="86630.A0A367IZL8"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="56"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="56"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH83135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="272" mass="31227" checksum="20DB1330A2EAC575" modified="2018-11-07" version="1">MNSRTSSTIAIRSRNAKKRSPCIIEQANVDISSQSYYPPGPIHIVPSWNPINKKEKPPYSYATIIAHAILSSKERKLTLNEIYQWITEHYPYYTNSNLGWQNSVRHNLSLHKAFVKVQRETSDPGQSRKGCFWTIQPGKEQAFIDNLEAPMTKRSGRRRSSQLSVGMPYPEATSDTAQCTSSNSSVYTTTSSSSSSLYDYECYYNNYYYTHSHNQSQQYPSQQYPSQSYQPQQYIQQPNLHEIYKPSYPLLFTGSAAATQYPMFYGSTLMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0D4</accession>
    <name>A0A367J0D4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002748">
        <property type="protein sequence ID" value="RCH83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0D4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="73" mass="8538" checksum="48F7E6B5325BD60B" modified="2018-11-07" version="1" fragment="single">MTTIVKMNRSMNENLSLDVLQKKTIILHYLGTIWRPRSGEIAMTEYRLSLYRRRYKANECNSIGTTSKERAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0U7</accession>
    <name>A0A367J0U7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002621">
        <property type="protein sequence ID" value="RCH83563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0U7"/>
    <dbReference type="OrthoDB" id="2269335at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="11756" checksum="57DF39C87F331E8E" modified="2018-11-07" version="1">MGTKLVNGIIIHACLKEIDIPLSDNNGAGIVDYLTAVISLARMVTSNFEAIQLMIQTAQQDNMTFLAKPATSNICYREGSPISEGNNITDTDSESYSVELGWEEEEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J146</accession>
    <name>A0A367J146_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002593">
        <property type="protein sequence ID" value="RCH83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J146"/>
    <dbReference type="STRING" id="86630.A0A367J146"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="305" mass="35308" checksum="FCE93D97BD65D502" modified="2018-11-07" version="1">MPFFRKKKSKEGLNEDSIVYSMTPRHGHGQDVVDENGIRQVAGCLPIDPINKRFLLVTSASNPGSWVIPKGGWEKDETQKQAAMRETWEEAGVKGTITRHVGVFAEKSRHGVKAHHWIYEMEIKEVTKKFPEQKKRERRWFTYNEAMLVVKAHYIKDAISLSSLSPLVHPENLEEKKKKKKKKKKEKKDGDEEDDSEDDGEEKKKKKKKNKDEDNEDDEENDEDDEEKKKKKKKNKKKDGSDEDENGGQEGNEDEEKEKKKKKKKNKDGEITELSEEEIAKLQFSKLGLESKTDVPELVGTETRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J158</accession>
    <name>A0A367J158_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_003605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002590">
        <property type="protein sequence ID" value="RCH83665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J158"/>
    <dbReference type="STRING" id="86630.A0A367J158"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="9">
        <location>
            <begin position="123"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="10">
        <location>
            <begin position="291"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="11">
        <location>
            <begin position="433"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH83665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="67163" checksum="0B2D87AD8D5C5038" modified="2018-11-07" version="1">MKIRTTSNFFVCGISYFFFWWALFALYCIAYQINRWRVYLTRKKRISGQEKVITSLPGSKLVSFLNYVVPIPFVTDMIAVKHIIGVTLFIIINLLFIFFAPFKMADDKPYVLPSISIFDRRAAFVGMVNWGFVFFLAQRNSILPKMSGLTFEELIPFHRWVARIGLAEFIPHFVYRMYRGYIKHYIVKDTLFEDLEQTSGTIAMLGFLLMFVTSFEYIRRNFFEIFYYSHIIGVIIAIIFACIHEPTCFAYFIPATILWVFDRAVRSYNSWIIKTTSVRVDEVASSTATQEGIFRVLFEYPGMVNFRPGQYVFVAMARAQSRILGYANWHPFTISEVFRLSHSIDSGIEERIAEGINEKEKRSTDIASLSDTSSLRRRANVGIDATTTMATFHAKALGNYTRDILKAAARNEPIEVAVDGPFGPQLQYQDFPVLALFGAGIGITPAMAIVKDCVERRSLGVKTVATEYIQLSWAVRSSEEVLPFMDMFSYWHEKMTKAILPIHISFTIYVTRAKDGHNYFEGMHGFNMVYGQRPNVSECLDKVKTLNPDRRVWVHTCGPTSLTKIVTNEAVKRHFSAHNETFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1M9</accession>
    <name>A0A367J1M9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002571">
        <property type="protein sequence ID" value="RCH83739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1M9"/>
    <dbReference type="STRING" id="86630.A0A367J1M9"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="714"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="846"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH83739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="122620" checksum="C05118F99EE1CD58" modified="2018-11-07" version="1">MSKKKARPKKNKILDAKTRFRLSSTTGHPLPLESIQQRLVGFWKSMTWPICVKIVKANIALTIAFGLFLIDPIRQLTGASGILAAVAVEFVHPSKSYGFLAEDIVYGSLMCCLVAAWSILGTFLSSLVRDQTNTMMAQPKVCVILIFFLIIGCFFLSIIRVRVEKANVGGMLAATIMVISLTAAVQNSEFTAAPTLQALIPTLVGFSLVFLVFFLFPENSTRVYVEQLIKVLEEFDYITQHQVNAFLQSEHHVDSVAVIHKKVDLLVSTLIQKKRMVRREPSYNVIATTDVSDLTTLIKQLHVPLRGLGISRAMEENMRNAEKKVMERDSQQNDEMHINRPRSYYGGTDDEEEAEAVEVSDSEEEEFTESNETTCSSQQLRQRKVQWEDSMKVITFWKTDYDEILNVVRPIYINLALACSEAVKESVKRLRRMQSLDPRYQGKPFFYKYYYRWKVGAEKEKEEEKAFYYDPSVDPSIPLYEAIRQFHEQRLVGLNKLYTSTGVPRRILFLLLTFQFNLHTFAKLLYTLTSLIYELDLNRSRRQLWWPHLSFTKWLFQDHQTEASFDLETPAAIAGTTYPLAIQESLRRRATVIAASAATHRRSSIVDLESQLPKKPLYKLETPYRGQVRTPEEHRQGHLEKVVINPWRRNALDPMDYHDPDAAYPTTKRQHFFYNVYLFIIQYIYTADAAFAFRAIIVVVVLSLPAFLEDSIGWYSESRGQWAVVVALIWMGPSVGSNFFATATRTVGTFIGAIQSIIIWEIARGTIPGLIVLTFFVNLPWWLVYINGKFWKASGLFALVTTSLILGYTYNLDEGNNQTTIFVITYQRTVTCLVGVLAALIISAFPYPRTGRVELRHRISNTIGDLGSLYSTFLALLVRDTPEDPETRRADKALFQAIANSIRQQIKGERVLLDQSRFEPTLRGTFPAHKYLYLLQVLDNILGLIIGMEFVMQKISFEWRMMVVKDTWQARKQMIASYLTALHLSSDALTNKSPLPPYVVRPTKARRTLTNLARRMDVFKVQHLGEREYTYYSTYMMNSEQLSVELELLVATVRDLVGPDSVSIWLNYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J241</accession>
    <name>A0A367J241_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002487">
        <property type="protein sequence ID" value="RCH84008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J241"/>
    <dbReference type="STRING" id="86630.A0A367J241"/>
    <dbReference type="OrthoDB" id="2287482at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="36676" checksum="85B6E5F6DA6B3C3C" modified="2018-11-07" version="1">MSVTLSPFTRSDPVSIPTSNNKNTDNEQSYKDMIKQLAAQAPEPYGAIPPLKRKQKKKRPKETTIRRLSYVENWLAVDSKESIPDEEDLKPSSPFRNFLSTDFLVLPLHMPPPSLSAQNEELPIYDSRPSSEIDLLHMEEVEEEDDEDEEEDDEIEYDIPDEQQRPKTLTKQRSIPSFSKSVRPSTSTTKSYAMSSSPPHQEESSSWIETLRRSLVLSTSPRQAKQLIPMPLPPPKPRMRKRRSEATTQPRFNPETNTYTRDTRSNPDHLRMISAELNMMRARKLSSPLKPRGFLPRRTDVFIRGENRRKSLLCNEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2A3</accession>
    <name>A0A367J2A3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002536">
        <property type="protein sequence ID" value="RCH83851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2A3"/>
    <dbReference type="STRING" id="86630.A0A367J2A3"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="383"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="453" mass="51847" checksum="61872ECBBD24F21B" modified="2018-11-07" version="1">MRCLLNTYKSVLPKCRWSLHTFRYSSSGGPSEKKLKAIPFAQHVNAASETFERYHGSGFFSVKLSQSSPPEQYFLPFWVVSATVHSTIEQAQVGRRTIRTHYNPATKKNESRWDTDWVWVPHKHSFTRDYSPLAHPKLQIYASHRYRRGLVEAITQGPALESAISFSPSLLDSKELRGIDPFAIYPSTAVRFAKSYIQSTEEKVADEYLRQVYRMDETRFLKVNVRLENVIVSPVYYPAYIFSVNYLGRTLRTFVNGNDLTVGGTKVYNWQRTAMVSAAGMATIMTMTGGIGWGGASGSFWLGIVLPTVAVSMLTLYYPIISLRIRDLIRDYEIRSMAHDPSTWDEDWVRGYAAYEDQERSRTWREERASQSWYTGTNADPKGYYRTLNVSPNASQSEIQGAFRGLAMKYHPDRYSDPEEKKQAKVKFQSISAAYSVLRDARKRQVYDQSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2M5</accession>
    <name>A0A367J2M5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RPL11_2</name>
        <name evidence="10" type="ORF">CU097_005899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002441">
        <property type="protein sequence ID" value="RCH84176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2M5"/>
    <dbReference type="STRING" id="86630.A0A367J2M5"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="8">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="9">
        <location>
            <begin position="264"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="375" mass="42590" checksum="22B479D9BCD28B7D" modified="2018-11-07" version="1">MGISRDSRHKRSATGARRAQYRKKRKFELGRQSANTKLGSKRIHLVRVRGGNYKRRALRLDSGNFSWGSEGISRKTRVLTVVYNASNNELVRTNTLVKGAVIQVDATPFRQWYESHYAIGLGKQKATENAEAEKKSKAVQKKIDARAATAAIDPLLNDQFNAGRLYAVIASRPGQSGRCDGYILEGKELEFYIRKIKSAEQQKVTKNPMRNLKIEKLVLNICVGESGDRLTRAAKVLEQLTGQTPVYSKARYTVRTFSIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELKTRNFSDTGNFGFGIDEHIDLGIKYDPSIGIYGMDYYVVMGRPGYRVSRRKHCKAKVGVTHRIKKEESIEWFKNRFDGVVSNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5E4</accession>
    <name>A0A367J5E4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adrenodoxin-NADP(+) reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_008962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002163">
        <property type="protein sequence ID" value="RCH85184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5E4"/>
    <dbReference type="STRING" id="86630.A0A367J5E4"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38338" checksum="CF4DE88C71945962" modified="2018-11-07" version="1" fragment="single">DLYGVESARTFVGWYNGHPSYRNLKLPLNDTDTVVVVGQGNVALDVARILLSPIDELRKTDITEYALEALSKSRIKHVHVVGRRGPVQVSFTSKELREQMSLPGIAFDADMDLIHREIEASQPIISKNRPLKRLMSLLEKGSPNKDTEKTWSAKFLRSPVEILGNADHSRVQGIKYVINRLEGPLEQRKAVPTEEYETQECGIVLKSIGYKSVPIEDVPFDSRRGIIPNEYGKILDGEKEVPGMYTAGWLKRGPTGVIVSTMTDAYETADTIVNDLQQDKEMLSGGSKDGADGLDLTFKERGIMPVSYSDWKKIEAAEFAIGEKLGKPREKFTTVEDMLAVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5K3</accession>
    <name>A0A367J5K3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002155">
        <property type="protein sequence ID" value="RCH85210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5K3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8437" checksum="036584D1851DDB85" modified="2018-11-07" version="1" fragment="single">TTSPNSTNSHYPKRQHSSRQSSVDAMTAAVWVTGFPGNMSKQQPSSSTSHHPDYTHPPQAQPTIDDHHGESRWLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5Y5</accession>
    <name>A0A367J5Y5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002132">
        <property type="protein sequence ID" value="RCH85305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5Y5"/>
    <dbReference type="STRING" id="86630.A0A367J5Y5"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000070">
        <property type="entry name" value="Endoplasmic reticulum protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="390" mass="44139" checksum="24D49F692FBEB39E" modified="2018-11-07" version="1">MEINKEEAIRCLRIAKNHYGNKNYDAAVRLAQKSIKLYPTEEAKEFLVKAEQTAAKAGPEEIKKEAKSTSSTQSSSSSSSSSTQQQSQEVKEILACGTDYYKVLKLNRNCTEVEIKKAYRKLALKFHPDKNKTPGADEAFKLISKAFTVLSDPQKRAVHDAGGGDPEQRGNGGFSGFRTQTYGASPFGDEISPEDLFNMFFGGGMGGRAYTFGGPTGFSSATFVGPGFRARTFNTAGGPYQRARSHQPEQQQRTGWSIFLQLLPLLLLFGYTLFSGLFVDDTPSFAFQSNSVYSQPRMTTRNHVRYFVNPAAFKPYQDNRNKLYQFEYQVEKDWLQSLQQKCFMERKHRQMLLDKSKGTFGFINRDEKLYQEALNMQLDSCEAVKRFRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6I6</accession>
    <name>A0A367J6I6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002068">
        <property type="protein sequence ID" value="RCH85557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6I6"/>
    <dbReference type="STRING" id="86630.A0A367J6I6"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="411"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="892" mass="100233" checksum="655BC4ABF80F17DB" modified="2018-11-07" version="1">MSGMNFTEKVEKIIARAQALTREFGNSQIMPAHIACAMFDETDGAALFRSIIEKTGAEPATVERGYKKMMVQLPSQDPAPTDVTIGSQTSKLLRNAEKRMKDQKDTYISVDHIILALSDDDTTFKPMKDAGITKKALEAAVSQVRGNRRVDSKNAEEVYEALSKYAIDLTQMAQNGKLDPVIGRDDEIRRVIRVLARRTKNNPVLIGEPGVGKTAIVEGLARRIIERDVPQSLQCKLFSLDMGALIAGAKYRGEFEERLKAVLKEVKESEEGIILFIDEIHTVLGAGKGEGSMDAANLLKPMLARGELRCIGATTLTEYREIEKDPAFERRFQKVDVGEPSVAATISILRGLKERYENYHGVKITDSALVSAAQLSDRYITTRFLPDKAIDLIDEAAANTRVQLDSKPEEIDVLERKRFQLEIEVKALSKEKNNKESNERLQAVREEMARIDEELKPLKLKYELTKGRLDEIRDLKQKLDELKSKAIQARNNYDLDTAADIEYYAIPDVEQRIAELQAEKQRKMSEDLANDQPSDAIISEVVRPEQIMEVVSRWTGIPVQNLAKSEREKLLTMETEIARHVVGQDAAIKAVCDAIRLSKAGLQDPRRPLASFMFLGPTGVGKTLLCKTLAEFLFNDERALIRIDMSELMEQHSVAKLIGAPPGYVGHEEGGLFESVRRKPYSVVLLDELEKAHRDVANVLLQVLDEGFIHDSKGRRIDFRNTIIVMTSNLGANLLADNVKGEEMNILKEQIMEVVRKHFSPEFTNRIDEVVIFNRLTQTNITNIVDVRLKEIEDRLADRRITLQVSQAAKEWLGAHGYEPIFGARPLNRLIQQKVLNQLAKLIIDGGIRNNEVAKVDISTDGSTIEIARNHESEAGYIVEEPMDEDQDLDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J725</accession>
    <name>A0A367J725_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CCP1_3</name>
        <name evidence="15" type="ORF">CU097_006302</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="PJQL01002048">
        <property type="protein sequence ID" value="RCH85639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J725"/>
    <dbReference type="STRING" id="86630.A0A367J725"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="168"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH85639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="373" mass="41445" checksum="5F3137740F293F2F" modified="2018-11-07" version="1">MNSISSSLLKNISSRTASRPIVTSTSALSANVRHAGAVRASLMHQRGYTSSATPKKGSSGRLAFLTLATLGGIGGYYYTSAQAIKTKTIPVTTTKKDIDYEKIYKEIAEMLDENPDYDDGSYGPVLVRLAWHASGTYDKETKTGGSNGATMRFEPESAHAANNGLAIARDLLEKIHQKYPEISYGDLWTLAGVCAIQELGGPTIPWRPGRQDAFEAKSCTPDGRLPDATKKEDHIRDVFYRMGFNDQEIVALTGAHALGRCHPERSGFDGPWQEAPTIFSNEYFKAISGRKWIKKTLPHGGWQWVDENNTDVMMLPAEISMYNDKEFKKYFDLYAKDEQKFFEDFAAAFVKLLELGVPFKGDEKVYRFKATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J822</accession>
    <name>A0A367J822_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001969">
        <property type="protein sequence ID" value="RCH85979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J822"/>
    <dbReference type="OrthoDB" id="2271790at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="310" mass="35643" checksum="E584D9E3C357FB30" modified="2018-11-07" version="1">MLSPKVLQSPSIESKTVFQPSYFSSNHYQYQLAVDAKRKYSVKDCIRLASQVNIKHDANGCYRCDLVASYYMTALKITREQEPIICNQDLFQLVSEMINLILSHRETSKYQSLVWFDLLTAELWDFAKQLKEESFENDLYIPMDGVIKRGSVDSSVSQESEELELEDEEEMFKRAIRTSIYHCRAVVCEQHKDVEQAIVYYRKCASVRPTVFESQQNMQKHALTSMRRLISSEVPSRPISTLKTRPTWSSTYSSDSASSSIKTLSTFICSNCSIEKQTMPVCAKCKIQPYCSIRCMKSHKSVHELTCSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J839</accession>
    <name>A0A367J839_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UBP2</name>
        <name evidence="10" type="ORF">CU097_005119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01001945">
        <property type="protein sequence ID" value="RCH86080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J839"/>
    <dbReference type="STRING" id="86630.A0A367J839"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02666">
        <property type="entry name" value="Peptidase_C19J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="435"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="820"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH86080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="945" mass="108323" checksum="D59E0EC5D39D5F79" modified="2018-11-07" version="1">MSPQVPALPPRQLIKVNSSSSYFSPLALFYHLETHQSDHRHVFKSISDKENKNIFACSICHIWLHVTSSSNQNNACSNPDYLCHHYHATAVAYECCGCQYQLQAQYQAPIIPLSLIKQLETTRPKGKSFAQTMQQSEQSPTMSTTFTTILIYVHDLLNGTKKNINTNNPHFLSRIGNTKESLDLLYAIGFKLENEYLVPPDIEPGTASEARLKQIREEILLTIDALRSELGEAAVPSGYAEKDVKVIPANVDTLFGIIPALEQSNVSTNGYLAEAYHYFGLVYGASDQLVSWTYKKLINEVQLDIHTAIDYLTRIANVTKSELLETLVVCEKSTGNIGYNDISDAYAYFNISLDSNVDDKLLIGLYQVKLSDEPEERNMHQDKLRMIAIAKNSTELIEFLKTEKGITSATSIESIQQIMGVPSHMLTAPTSPVPVGLNNIGNTCYFNSLLQYYFTLLPFRQTMMNNEMYIEDENSEPKKIGGIEVDQLEIKRAKRFVELLKTLFVNLQYTSERAISPEYDLAYMALLNERDQQGDDTNSTDTDKEAITKDTEEVEYEATDNASLSSTPADAPPSYDEVVNKTDVIMEEKTPTKPKERPSVDAMMFGKQQDVTECMGNVMYLVEAALKPISKTEDGEQVDDMIRQLFYGKARQIISYCDDTTLKVIKKEMEEDFSHVIVDASEGKDLYDGLDEYFFENQLESFQGGHEATRQVSVKSFPPVLQILVQRVQFDRATANVYKSNAYIQFDKTIYLDRYMDDNFERLKDKRTEVAKWRREYEAYKQQIGKYKKFKTCQLPVPDLLEATYKILEEFKSEWSTEERDKYEIALQLLEKEAKETKKIIEEGTEKMKSIKSDIRNQYKDYKQIEYKLHAVFIHQGQANYGHYWIYILDHQQNQWWKYNDSLVTKVKESEIFHDTTGSTANPYFLVYIDSSKIDELVETIVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB75</accession>
    <name>A0A367JB75_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01001710">
        <property type="protein sequence ID" value="RCH87184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB75"/>
    <dbReference type="STRING" id="86630.A0A367JB75"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="114"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="327"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH87184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="649" mass="74269" checksum="600BF02169C6BA8B" modified="2018-11-07" version="1">MLSRLTTQAIRLYSQRNLATLPSSFVNRSRSNLAQPLFKHTPVYGFKTIPYSLLHTVSVNKANATELLKEETTIEPIEGKKRFDSIDTLQLSTQKAIQRIFKYQEMSSVQEAVLSRLPNQDDMFVKAKTGTGKTLAFLIAALETAVAGQRPTQWKHFDGTSILIISPTRELASQIADEANKLTAFYPFKVHCLVGGESKRRQISNLERQRADIIVATPGRLYDMLSSVPRFKKMCQNLKVLVLDEADQLLDMGFKQELQNILTEIPEKRQTMLFSATISPEIRKNLGDFALSPDYKLIDTVGENEVHTHMHVKQSAIVAPYQKQFALIHDALNNKESAQSGKVIVFLPTTKATMLYAQIFKKLLPDRDVYELHSKKTQSSRSTIAQRFRKSSKGSILFTSDVSARGVDYPGVSLVVQVGVPSTREQYIHRLGRTGRAGKDGEGLIFLAPFEKKFLKTELSDLPIEQVNTTLDEVEEERLNNELSRVVSYVDHESIREMYTAYLGYYAGRLSSMGMNRRIAVDEANNLLDALGVQDKPHLSQRFLAQIGIGSSREDGGFQRRNNFRGGSFERKNFNKREDSFDRRSYSKRDDGFNRRSSFKEDRFERKSFSREDRFPRDNKFERRSSFEEDKPQRQQNRWSQRGSSRKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC56</accession>
    <name>A0A367JC56_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001647">
        <property type="protein sequence ID" value="RCH87486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC56"/>
    <dbReference type="OrthoDB" id="2121849at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="384" mass="43514" checksum="2F8962F5AE3CCB55" modified="2018-11-07" version="1">MASLFFKDYFFPSELYEKDSGSFTTPVQTLIDFAPHILQELPKKEKDQKPIKSSREDTWTKESVKARPKSYFRSLLTSDTSKTITEFVIRCGNEYLRQTSERNQDNKYRNRHKEKKRRSTFWRQDDTSSSSEEEEEEEEKNKAKSNKDKEDKKKDDQLVTQKDDKNNTLVKSVAAAGFLSFSLYSTYKASAAFSEISFHNQLEILLSQVQAILQSTDIWIREHEKLGDKVPNQVRSDVAYLKELVDFIERLDPRSHKKMETAGWGCGALGGLSALGGIVVGSTAIATGGAALAIGGAIVMISSKAQGSSKSTLGARLLLEGQVRDRVSILLKDKKERQRVIQHEFDKQSLKSEPKPIPIREEYIKEPKMDKQPPKKAKIPLSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD71</accession>
    <name>A0A367JD71_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001575">
        <property type="protein sequence ID" value="RCH87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD71"/>
    <dbReference type="OrthoDB" id="10301491at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="248" mass="27634" checksum="6FF9EA54F6EADF82" modified="2018-11-07" version="1">MNDKQELKTTLLNPVASSSKTKRHVPTLLSLPECLAYTCPEQSNSDLSSSTAIGTTGQDKQSFLITRLPKAMIHQWKQISSLRQHSVKSRLSSNDMKDQKRIYSYYRDPNISPCSTAVADEEKGYFHIHAAQKIKKTPRGRIAALVMILFGFLIVIVFIIMGLGKATESNEDSIDSMQNSTISASFIDANKLMMMPTTHLPRQTHNQTELMPTPICDTMTRFVLIEDASVLSQIITQGVTPSYLPIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDP2</accession>
    <name>A0A367JDP2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001552">
        <property type="protein sequence ID" value="RCH87989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDP2"/>
    <dbReference type="STRING" id="86630.A0A367JDP2"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="737" mass="82784" checksum="7A6E97D5704E9F8A" modified="2018-11-07" version="1" fragment="single">ALTTNQQASTEHFKSTLYKNTASSLASSSNNNLSMDKSEQQTKELLSHTFPTKKPQWPPASIQPPNKVQTVSPRPDQQQDQQQHSNILTPSQPLAATASTSVTASQPSKPLIQTTKLPAQAAQSSIQTQVPAQTPKAVQQVSVPALQSPKPVQGKHPEVPKSIQQQTIPQPSEPVQQQQPIPPKPTQVPTPQPPKPVQQVSAPTPQPLKSVQQQQVTSSRPILQQQQAILPKPIFQQQQSTTQLPSFVLSSPRPHQYKLAEQGLKYKLNQQTPRQDQPKISIIHEARDPRLKTIVGKDPRIKKQQQSDPKQSPETNGELLEHKDLEMDVVLFKGDKEIAPITLKRKQKCYHRDKIIQLINAQAKGPNQLHIISYLPLRALNEIIHNRRVTLIDILMTKSLVNFGKLRSFLQVNEIAGLAYDTNNTKDILVLLPVIDLHKLTNVPSDHGLMNYYHQLCAIYIEGVPEKPNIIEGFSGVGPLTNRDYTMLEWELTAAYLRFPPELKRLRTEAKFFIYGNSLAATLLAKSLNATHTQSSPKSHVMMFDRYNKTIFTKSLTRHKKEPSTQIWEFGVPDLSTGDMLPPEQVFPNYSGGFITTDAKNIIHRPGIIDDISEQVAKLNADTIANGKWKFVLPHNFFVQMKHVINSEIHATAGREAVVKIALALSEGRLDILRVWSSGEIQEKDSLEFMDNIAHNYYKEHQFFIYVDDIDAIPVNKRLNSIDFVTSANIYSSFALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE69</accession>
    <name>A0A367JE69_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001543">
        <property type="protein sequence ID" value="RCH88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE69"/>
    <dbReference type="STRING" id="86630.A0A367JE69"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44314" checksum="CCE0C1A473EB55E2" modified="2018-11-07" version="1">MVTAINEYTLENNTVFSIAGKGLKLNTAEDVKEFVETIDQMDDLEVIKLSGNTIGVEAGQALAEALKTKTKLKQALLSDIFTGRLLSEIPLALKALCDAFEQVDLLELDLSDNAFGPAGAQPLIDFLSNTKTLQTLRLNNNGLGIGGGTMIAQALQANADKAKAENRTSSLRTIICGRNRLEDGSSKALARAFASHGTLEVVRMPQNGIRSDGIRTIVEGLRECKNLKHLDLQDNTFTVKGSKALAAALGSWPQLEVLNVSDCLLSRKGSIHVFGALHQNTQLRELMAQYNEIQADAIRILADAVKGHLNLLEKVELNGNRFDESDPAVDILKEALAKWDHEDALDELDDMEEIDSEEEEEEEEEEEEEDEVVKEAREAESQTPLPDKDQEEELVEKLSKTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEA5</accession>
    <name>A0A367JEA5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001537">
        <property type="protein sequence ID" value="RCH88061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEA5"/>
    <dbReference type="STRING" id="86630.A0A367JEA5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="73" mass="8412" checksum="31C5B1DC9FAFF98E" modified="2018-11-07" version="1">MDQQQKGYYPPPPQNQQYYAPPPPNQSGQYYQQPYYQPQPQPQAVYVQQQPQHKDDSSILAAMCFCCALDAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEH8</accession>
    <name>A0A367JEH8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ectonucleotide pyrophosphatase phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001523">
        <property type="protein sequence ID" value="RCH88141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEH8"/>
    <dbReference type="STRING" id="86630.A0A367JEH8"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="51686" checksum="A35D43086D03D01E" modified="2018-11-07" version="1" fragment="single">MATRQEEYEMTRSHSAGSSRDYERQEEEEEEEAQLLDKEDSSSSSSDDEWTVIVDEDQQELPPDNPIMRYVCLGLAIGFGYFVVRMILTLSGHDHTKHREAEKLYHNGSDYFASTVLLISFDGFRPDYLDRHITPNLKKLAEDGVMAKYMHPSYPPSTFPNHWTLVTGLYPEIHGIVSNSFYDPEMGLFQHTDHSATSNHSWWKGEPIWLTSRMHRQRTASIMWPGSETHHNTPDYVVPFNGSMEMKEKMDITLRWLDMEYDQRPQMISIYIPQVDQEGHRGGPNSPKMNKYIQEADDAIGYLTDELSKRNLDSHVHIVVVSDHGMTATTKDKLIYYDDILPANLLKYVRNKSPLSTLEFQPNMTKETIQQVYHQLSKYTHTHHFNVYLRQNMPDRYHYKHSDRIAPIVVIPDIGYTFVTHKMPLEQLGAGDHHGYDNLAEDMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFZ4</accession>
    <name>A0A367JFZ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="8">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_011283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01001393">
        <property type="protein sequence ID" value="RCH88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFZ4"/>
    <dbReference type="STRING" id="86630.A0A367JFZ4"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="317" mass="34290" checksum="7796083FAC380BBC" modified="2018-11-07" version="1">MTAITEETYKTSADYIASRLPEEFKKVKLGIICGSGLGGLVTTIDQTTKVEFHYKDIPGFVSSTVIGHAGKLVFGHLGESRTPTVFMVGRFHFYEGHSMLQVTFPVRVMALLGVQYLIVTNACGGLQPTFKVGDIMIINDHLSIPGMVGNNPLVGPNMESFGTRFPAVSDAYTYGLRKLAFKAAFDVGISPDDIREGVYCMVSGPSFETRVEARYLASIGADVVGMSTVPEVVVARHAGVKVLGISLVTNAVINARGKDAKLEVLREMGLTDCVDEEPDTEIYVANHEEVLETSAKKSNDMQRMVARFADLLAASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG81</accession>
    <name>A0A367JG81_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001388">
        <property type="protein sequence ID" value="RCH88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG81"/>
    <dbReference type="OrthoDB" id="2217590at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="17310" checksum="593EC80D2D181A7A" modified="2018-11-07" version="1" fragment="single">MKTPEEVIRHVEVLKKVEKLKYFESMQHSVIMKSNLSQLVHAFVSRLFDTSCYKLLQNEDIQAMLAEERIDNDEAKLIITRHCPKFVETVVIINEIWFLYTSFCAFIHKKELDDCADASRVGSQTEPVSFVRRKTRAGSDYFEQMART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGA2</accession>
    <name>A0A367JGA2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell differentiation protein rcd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RCD1</name>
        <name evidence="2" type="ORF">CU097_001030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001385">
        <property type="protein sequence ID" value="RCH88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGA2"/>
    <dbReference type="STRING" id="86630.A0A367JGA2"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="373" mass="41626" checksum="DCAFE37B0A8D4834" modified="2018-11-07" version="1">MHPNSHLHQYIQQSSLANAAAAAAVNPLSASLPNNALSQHFPAMRSTNGANADPYVFAQMLGNPSQAMPLYNIQQQQQEAAAAAHAHAHAAAQQQQHKLAHLDEEKIYGLVLELLNPSTREQALLDLSKKREQFEDLALVLWYSYGVIPVLLQEIITVYPLLNPPTLSGGASNRVCNALALLQCVANHNETRSLFLQAHIPLYLYPFLNTTSKTRPFEYLRLTSLGVIGALVKNDNPEVISFLLSTEIIPLCLRIMESGSELSKTVAIFVVQKILLDETGLYYICQTYERFYAVATVLHNMVNQLVETQAMRLLKHVIRCYLRLSENPRAREALRQCLPEPLRDSTFHQALKDDIATKRCLAQLLLNLSDGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGV9</accession>
    <name>A0A367JGV9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="16">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CU097_010145</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01001333">
        <property type="protein sequence ID" value="RCH89192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGV9"/>
    <dbReference type="STRING" id="86630.A0A367JGV9"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 21" id="KW-0349">Heme</keyword>
    <keyword evidence="11 21" id="KW-0408">Iron</keyword>
    <keyword evidence="8 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="23">
        <location>
            <begin position="104"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCH89192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="495" mass="55860" checksum="D9C766B8C2CB3348" modified="2018-11-07" version="1">MAVISLQEVEKHNTKDDIWVIIHGKVYDLTNFLPEHPGGQKVILKYAGKDATDAFDPIHPPDIIQRFLSPDVCKGEVDPEALAKVEKVETEEDKRVRIARENMPRLEEMYNSFDFEAVAKTVLKSDAWAYYSSGADDEITMRENHNAYHRIWFKPRVMVNVQDVDPSTTMLGTRVSFPLYITATALGKLGHREGEVVLTRAAAKRNVIQMISTLSSCSFDEIVNASVPHQSQWLQLYVNSNRKVTETFIRHAEKRGMKGLFITADAPQLGRREKDMRQKYSLDAPEEIERSATEMRRDEGAARAISKFIDPSLCWDDIAWFKSITKMPILIKGIQTPEDAVLAAKHGCQGIVVSNHGGRQLDFAPSAIEILPEVMSALKREKLDEGFEVYVDGGIRRGSDIFKAIALGAKGVGIGRPSLYAMSSYGEAGVERLLELLQNEFEMVMRLMGVTSIDQIKPEMVDIRNLQDHFVANPKDYLGSYAYDKMYPRTHFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHE9</accession>
    <name>A0A367JHE9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycogen synthase kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RIM11_2</name>
        <name evidence="13" type="ORF">CU097_008426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Protein kinase that acts downstream of the MPS1 MAPK cascade as a highly conservative signal modulator that dictates growth, conidiation and pathogenicity. Phosphorylates HAT1 at 'Ser-8' to block its translocation from the nucleus to the cytoplasm where HAT1 positively regulates appressorium development and pathogenicity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001299">
        <property type="protein sequence ID" value="RCH89378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHE9"/>
    <dbReference type="STRING" id="86630.A0A367JHE9"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0309">Germination</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="56"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH89378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="47125" checksum="A2C4967C86D23D26" modified="2018-11-07" version="1">MSALSHFKFSGNKEAKHDAVKKKLMLFKVSDAFDSFRTIRVPAKDGMSGHNMQLQYTHQKVIGNGSFGVVYHIKLSHNSEDAAIKKVLQDKRFKNRELEIMRLMHHPNICGLKAYFYTQGDSKKDEVYLNLVMEYVPETVYRVCRHYTKLKQTVPMLIVKLYMYQLFRSLAYSHTLGVCHRDIKPQNLLVHPITGELKLCDFGSAKVLVEGGTNVAYICSRYYRAPELIFGACHYTYSIDIWSAGCVMGELLLGQPLFPGESGIDQLVEIIKVLGTPTKEEVLIMNPNYTEHKFPIIKPHPLAKVFRSRTPPEAIDLLSHILQYDPRKRLTASEAMVHPFFDELRNPETKMANGRDLPELFNFTREELSVRPDLIHKLVPAYCKENLLQSGIDIDNFIPIPLKDLRLNIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIW4</accession>
    <name>A0A367JIW4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar transporter chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VTC4_3</name>
        <name evidence="9" type="ORF">CU097_002183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001221">
        <property type="protein sequence ID" value="RCH89826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIW4"/>
    <dbReference type="STRING" id="86630.A0A367JIW4"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="VTC" evidence="8">
        <location>
            <begin position="171"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="626"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="740" mass="86322" checksum="03CA54CD78576585" modified="2018-11-07" version="1">MNFEQEFKENIYEPWRSEYVNYEEIQFNLKNQYISQPEFESIISAEADKVELFINRKQREIESRISYCERSLSNVTSPLVYETTDDALTEMLLDLNDLSKYTRYNFLALQKLINETKFDHSRLLYWLRSKSLDKQRFDLALVKIATLHDLCRLHGKARPPSPSNIDGTFEKAKFWVHPDNITELKAILLFHLPVVISNTDKPIEQSDSSVSSIYFDNPYFDLYQNRLQRDEGAEAIRCRWLGPVNEAKEIYIERKTHHAPWMNGLSVKDKISFNVDQVDGFVKGTYTAEQYANDLRHKKNMSEEQVKKCHAIASGIQMSIQEKELEPMMRVFYHRTVFQVPDDPRIVITLDTDVNFIREDPPRGHWRRENMDYPFDSEEEVYSFPYAIMETTTQIPPPEWLTRLLDSRLVYEVPRFSKYLQGVAYFWNSRLPLVPWWLEQLELDIRNAKQPTGNFSGLSRSKSLRPLIDGKYRMGYLESQLERSSGFKRTVNRYSTASRASNPFDDPIWSQHSPLSPTVASSISRVMSPSDGRRTTIFLDSASTDFLIGGKHTPRSSYLQVEKDEKEKERLFSEDITIVEEGRRNKKEKKAEEEKLGVEVDEEEEKPKKKKKKNKEGGAMVEPKIFFANERTFIHWLHFATILLSAAVTLLNFGDRVNRIVGAVFFGIAFLFSFYSFGFYRWRAHRIATKPHLRFDDIFGPVLLCILLIGALVLNFALRFNTPPQSNTYLGVNNTNNSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ17</accession>
    <name>A0A367JJ17_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED23_1</name>
        <name evidence="6" type="ORF">CU097_008652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001201">
        <property type="protein sequence ID" value="RCH89944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JJ17"/>
    <dbReference type="OrthoDB" id="9982951at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH89944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1505" mass="172599" checksum="9967CF17885A7F53" modified="2018-11-07" version="1">MLSCLKSVPQQTLFHAGVTTPVILGVIKQVLLGMTSLPEKNMNLIQQKCFSVGRELLNLFLIRDPSVVKESDDMDIDASIQNFTATSNNNSNSNMSAISFYDVIYSFPELYGHLSTTPATTEMYPPSPQPSIANSNIWLMTLSFMTASILQDHKLLERISTLMAINIIKHILKEINTLPPSLNTIQVNCINKGKELINLLLLGASGDGAGVVSHYDIIVALPDVYGHFLGGTFPQSIHWTLEKFINELGKRRRHLAFLMMPPDASWPLISQMSRRHEYNDLTTRTSYHMFEGDLIEFVKEGNSTNTETHFRDMLHQRASMDEFRQLAMSLTQTGLDTTQIRKAMVAKVRDVIRCIQQHSRKGRAEDKDEKAFEPFNPSLTNIKGEDIKMAIPENIHLWELMTETADQLYSFVSGEFFSYEDILQDFYDLVYKPDGTPYTSSTKNHIAKDNGLVWLLLQLFYIEKVSTNVIQKDFENDERLFDKLVKLYNEEQTESKDAFTLRDLSLQCAINHQKAHIKDVTNIKQRHPLITASLQYASLCYHIQAYFNNHYHSNVPTNSTLFRNLDLQEMTKIAMESQLRQDVVPYTLYVYLVPTKADIDTLGHSSTTYIKGGTLNYKLLDLLCINAKHRLLQVIYKMMLDSELGPRYQSTASPVACVPPNVLDVVYKLLYSAPCSAELMVKEIFDKLRRCDKMIKMKRTGESESLPTQLPDQTMRWLQTILQLMNYRFIRFLKYSPLSSGLLHYIRYSISFLESRQCYQSLESFTVNIINMQMDVKLLRSLDDPHREKTIWFGESEMLARLTVCTISRLIKTRGQADIKTEQIHRVLSNLYEHSLDWSSAALEHFPPVVRAFYESPSNQAPRPSVTAAKVQQIVSNNKVLTTYLLQGSPEAERMAIQYFSSAENQSSLLCIMWVIAITRSTAECFHMQSVRKLLLLIPPSKMATNTIDLMDFILSVEYPSNAQSSIFVLLDAFIWKYQWVNFNHVLFALTKGSGTPERTSKAMTALRYLLLESPEFVKRVHKWDSLGFSCRPWTEEDFQEKLMAYLRVFPEYSEFEAFAMQQFEPRIDLSPPLQVKLPIYFGNVISDFVVSLENILMRLVEYGQTELLIDILDKHGHLFKYHQCPLSFVANFFLYYHASPTLMNLSVRKRILRLIDFDQYNIAPEAVAYAQNEDDDGSLFDAGYFERVIYKLAKSINPQTCAPRANPDLPERHFREIGSPAIEGIVIATLETMLTTIAPSTIIKYFLDLALLRESHHVGVSALTIHAIGLLIPLLPPQDFIHPMFKELNDLILTDPYLLAVSEPCRLIRCGIPKSVNGKYTMTQSLPDLTTTPVLKDSMSARVGKAMIFPYIFNDYTFNLHNYSTNAPNSFLTLFHSMVHYSSLDIFGIFLEYFQTLRNSEKLLTDVQLLYVCFLIGPALHRIEKLDISEAGFLVELMHMVKQVTTLMDMKDGWTTQALEQSFDFLYHIRTRFVKTNELAAQIREIIRSMNPPISQRLLRLVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKG4</accession>
    <name>A0A367JKG4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative electron transfer flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CIR1_4</name>
        <name evidence="9" type="ORF">CU097_010708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001132">
        <property type="protein sequence ID" value="RCH90375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKG4"/>
    <dbReference type="STRING" id="86630.A0A367JKG4"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="44758" checksum="A0450484AAE084CD" modified="2018-11-07" version="1">MTVKSPFYNKPSTATSVDSCHKCPSEPSTKTQVSMTADYMCVNKVQQPVGFEQAKVTTSSSNNQHIIEPSNSSVAKSDIGSTVVTSCSNCGTTTTPLWRRSPLGEAICNACGLYYKARNTCRPVWLKRNSLKQRQQQQLQKNLVPRQQPPLLAPATHKPIQYKQPQQPQQPQQPIAIQPAFSSPPMPKPLNNESSNTSDFVCANCHTTTTPLWRRNEAGQPICNACGLYFKLHNVHRPMTMKRSTIKRRKRVTAANLVTHKPPMVYQPLKSDDKREHLRPLLPSPATSPSPEPIEPEIQQQQQRYYLPSPPMRPTKNNIACLLNPELPRPHLPSPPMAPHDDILPCSPINMFHPVDSHVLEAHRNELKREVNNLTSLLSRTTAMLQNIDHVMAASLHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKW1</accession>
    <name>A0A367JKW1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001102">
        <property type="protein sequence ID" value="RCH90568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKW1"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="34871" checksum="E2FB26C9F6B71E6B" modified="2018-11-07" version="1">MCILFWTVENHPKYKFIFAGNRDEFLRRPTARARFWEEADENILGGIDLEAHPMDNVKNGTWLGINRQGKFAALTNFREQRFKGTVTRGALVRDFLYSRDPVHMAIDYVKSRAEDFGGFSLICFDFGNKNQVEMMYITNRENQLVTELEPEKIYGTKKKYKDSICVLTMTGLSNSILTKPWPKVAQGKELFEKIIKSGNNDPKELTEALFDMLSQPMTDTENVDTIMNNLKERIFIPKFDFPDITGIKEPSYGTRTSTVVLIDYDDNVTFVERDWYDSNLSLCKSGECDERSFRFQIDQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL07</accession>
    <name>A0A367JL07_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001103">
        <property type="protein sequence ID" value="RCH90559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL07"/>
    <dbReference type="OrthoDB" id="2265221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="35006" checksum="49E96BDBB5013B99" modified="2018-11-07" version="1">MKQCMLRNPLTYRKYLDIVEEKEETNFKRKKSELVTESQVIQFVNNVYSVDDFGNPEIYIKKLTSTKDIFELVKENSTLFSNKTSRWCSSNKLKFLNAVRDKNQGTRKRNLFVMDDIYRDCLITSITEYLPNCQQSLKVLQNNAFEIVGYTRKSPTADTSDNCVKLLNKMINNLRSRSFASHIFVSSSSRVSTAFVERDLKVDQKIYEQLDAVDGTTQDFIKYINASKHSICLAVLDFGGLSSRYHHVQKLLKDYPAIKKVAVDTFMISDELFIYDTDDLKANASLLERFNCRYKLMQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL97</accession>
    <name>A0A367JL97_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001081">
        <property type="protein sequence ID" value="RCH90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL97"/>
    <dbReference type="OrthoDB" id="2213130at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="374" mass="42360" checksum="6329A558DB16E791" modified="2018-11-07" version="1">MESSFASKQFWLQKTRLMTDLDAHLSRAEYVQKVIQQEIRALPDANCSTSFRVSSHDTTYRSMSPAIDDNTNSISPNSDNQETNDWQESANTPVLADSVLNSNCFVTTDNENSTDDSASADMTRHNDADLLDLPGHQTSSTLLSRTNASAGWMFKGTNISTLFMIFQQKSEEEESIVIVEEVELNLWELWVIVLIKMKDEDIHEYSLEKLNIIQIGNNIGSDTTRKYYPKDLVQKTIKNTQPAALLTQNPEFHNHILNLRVSENPDFEHILASTAPHLYSADLVKRFLTNVIHSFQLYSADGVLWNKNHNLEVAILEMTGPFKKHNPPKETKDYIKSGYGLVAMLHAIGREYQYDGFGIFKQIGVFFVQGTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLW2</accession>
    <name>A0A367JLW2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RPB1_2</name>
        <name evidence="19" type="ORF">CU097_006910</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="PJQL01001045">
        <property type="protein sequence ID" value="RCH90934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JLW2"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="18">
        <location>
            <begin position="241"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1510"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="933"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1517"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1553"/>
            <end position="1766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH90934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1779" mass="197206" checksum="739EA76284559322" modified="2018-11-07" version="1">MNGHPFAYSSAPLRRVDAVQFGILSPEEIKAMSVAKVEFPELYEEGTQKPRNGGLLDPRMGTIDRNYKCQTCGEGMAECPGHFGHIDLAKPVFHIGFLAKVKKILECVCFHCSKLKIDQSNPRFERARRINDRKVRLRAVWDIAKTKMTCEGGDEEDGLEEKEEFNSGKRKSNHGGCGYKQPLIRKDGLKLYAQFRASPGDDAGSEGKQLLTPAKVLQILKNIPDQDIKDMGLSEEFARPEWMIITVLPVPPPQVRPSIQMDGTSRGEDDLTHKLSDILKANANVKRCESEGAPVHVVNEFEQLLQFHVATYMDNDIAGQPQALQKSGRPLKSIRARLKGKEGRLRGNLMGKRVDFSARTVITGDPNLALDQVGVPRSIARNLTYPEIVTPYNIDKLQQLVRNGPLEHPGAKYVIRDNGERIDLRYRKRAGEIPLQYGYRVERHINDDDVVIFNRQPSLHKMSMMGHRVKVMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSLETRAEITEICMVPKQIVSPQSNRPVMGIVQDTLCGIRKFTLRDCFLAKDLVMNIVMWVPSWDGYIPPPAILKPRPLWTGKQILSMVIPKGINCQTFHSTHPDGETTLISPGDTRVVIENGELICGIVCKKTVGTSNGGLVHTIMNELGPEAAKDFLSGTQLVVNYWLLQNGFSIGIGDTIADQVSMATITNIISQAKQRVQEVIITAQQDKLEVQPGMTLRESFEAKVNQTLNKARDDAGKMAQNSLKEDNNVKQMVIAGSKGSFINISQMSACVGQQNVEGKRIPYGFKFRTLPHFSKDDHSPESRGFVENSYLRGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDVMVKYDGTVRNSLGDIIEFCYGEDGMDAATVESQKFASLRCSNEDFEKRFRVDVMKDGFKKGTLSYNIRQKIEGNEDAQAILEQEFAQLQEDRHKLQTTIFKNGEDKWPLPVNLSRLIVNAQQIFHIDPRTPSDINPFQVIDGVSSIVDRLHVVRGKDKISAETQKNATLLFGILLRSTLAVKRVVEEYHLTSQAFDWILGEIEARFLQSVVAPGEMVGTIAAQSIGEPATQMTLNTFHYAGVSSKNVTLGVPRLKEIINVAKNIKTPRLEVWLDAERSRNIELAKEVQVKLEHTTLQKLTSVAEIYYDPDPRQTVIAEDVDFVETYYSLEDDNSPFVTRVSPWLLRLELNRAMMVDKGIYVTDIVQKISEEFRHDLHVMGSDDNSEKQVIRCRVMLDENEKNAEIDDENKPEEDTFLRKLESSMLSSINLCGIPGIKKVYIVERKNTVLNDKGSFETTTEWGLDTDGTNLQEVMCQEGVDETRTYSNNTVEIMEVLGIEATRKALLKELRNVIEFDGSYVNYRHLALLCDVMTNRGHLMAITRHGINRAETGALMRCSFEETVEILMEAAAVGELDDCKGVAENIMLGQMAPLGTGEFDIVLDEELLQTVPQDHRQNLQMGITGDVAGFATPGPGYMTPGVATPYDTRSPDWVDFSQPSSPSEPMFSPMGNTGAAGIASPWRGDLSPYAQSPGYSPTSPGYSPSSPSYAASPGYSPASPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSQNANNRKKRWPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JND0</accession>
    <name>A0A367JND0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000975">
        <property type="protein sequence ID" value="RCH91395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JND0"/>
    <dbReference type="STRING" id="86630.A0A367JND0"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43275" checksum="636194CF24209F40" modified="2018-11-07" version="1">MIPFIVDTINQSMTPDVTASNLYQILSTSITDSASRKSSTSLIMFSVDTIVGSVIFGYLGECIIAFSVILLMLVVISDKIKHRRPLLMFSVFWLVLSTVLFMFGNVFQMLQLARLIQGLSNLCIWIMGMCLIVDMFPTNKAGIIVAAHSFGFLIGPPVGRGKLNSRLMYNSDAYHEFVALFQTTGYKASFILCMKNPSECLNPGRLDEMNELTFSTVDSERSIYDNQEQSVETEKGRRMTYLKLFQHNRLLNTTLMALLQGFVIAGLDNSLTIRLASEWKYTSGQIGLIFIARVIPTFISAPFAVMTPVQFEIACIVRFHNEGGEGDDSMGRSYGLFNIAYAVGGIIGPLTSGYLCHWILLALYHHGLHVSFTCSIRVILIGGRRVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP22</accession>
    <name>A0A367JP22_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FIS1_2</name>
        <name evidence="12" type="ORF">CU097_001617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000968">
        <property type="protein sequence ID" value="RCH91451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP22"/>
    <dbReference type="STRING" id="86630.A0A367JP22"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH91451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="622" mass="71624" checksum="0764058B33BAD81B" modified="2018-11-07" version="1">MKFNPTPSVQDADIALSPAELEVLRRQYIKEGEYATIQTKFNYAWGLIRSTKPDHIELGIKLLTEIYTDAPERRRECLYFLAIGNYKISNYSEARRFNDQLLKLEPRNEQAASLKKLIDDKVSTEGVIGLAIVSGVVAVGAALIAAVVKREYLKHRKHPTSISQPLNDVFITKPKNDNKTMPRIPLKRAIDALEDDISDQPDDLSTPSKTTHELQDTQHEKQIENTQEMHPIQDTIQSDTMPQEDIDMEKQTVRSSSFSEKELTDVESLAYTQTTDSQLVRDSMINTQEEEQLEDEEMMKVTHLKPDESKEIEKLEGTEQAMDVQVEQTEMQLEEGDDQARQLEVDDDQIKQAEADGDQARQLEADEDQARQLEVDDNMQAEQTEIQLEIEQKETELMGTDQLEIEDAKQSEEEIQDELVRDDAQSAYGYDGMELLNNDALADEQPIASPISKLSEGIDDLAFLDDKASDVVDAHRERLDEVIDELKSSIRSNYQSKSMKLRDIQAEVLDSVIVKVIKDEKNKSNNPFAHRVINHFYDSLSATLNHQVKLYTEYQKLQSQKQRLSKVRQKYKMELLDIERKRHQVRIKIEEERTAFEKMDQRELILSNLDTFFKDIQSLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPE2</accession>
    <name>A0A367JPE2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000919">
        <property type="protein sequence ID" value="RCH91798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPE2"/>
    <dbReference type="STRING" id="86630.A0A367JPE2"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="214" mass="23949" checksum="31CD82EF8A99B61F" modified="2018-11-07" version="1" fragment="single">KVSAAAVREIVQAIQAGSQEKPRKFVETVELQIGLKNYDPQRDKRFSGTIKLPHVARPRMTVCVLGDAFHCDQAKGAGMEFQSVDDLKKLNKNKKLIKKLAKKYDAFLASEALIKQIPRLLGPGLHKVGKFPTPVSHNDSLVDKANEIRATIKFQLKKVLCLGVAVGHLDMTEDQLIGNIMLSVNFLVSLLKKHWQNVKSLYLKSTMGKPHRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPW9</accession>
    <name>A0A367JPW9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000900">
        <property type="protein sequence ID" value="RCH91935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPW9"/>
    <dbReference type="STRING" id="86630.A0A367JPW9"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="544" mass="61971" checksum="A3BFBC81F629E8A6" modified="2018-11-07" version="1">MNNLDQYNDKFSSLNYRYMEDDVYNRYPSPELEIETPPFQDKSWQYTRNRDDIFHGVIDVNVQDYSTEEKALVRKIDLLVLPIVCTLDFLQFLDKSTINYAALMSFKTDLNLQGSQYSLLGTMFYLGYFVYQLPNNFLLQCIPIARYIGALVILWGLVLLCTAFVTNFSQVAALRFLLGFFEAGIYPCLTLLISTFYRRAEQVIRLGAFWICNGFALFTGGLVAYGIGHMTNIAGLKAWQWLMIILGSATILMGIITFFFLIDTPKSPALQLNAEQELLVEERTKDNATVRTTEIKREQIMEAIKEVRFWCYSFACLLINLQNGAMTIYNGQIAQNFGFNVRNPAQLTKYFMLIYIYLWQQLQSMLLTAGAGGSTVIFIVIAIVAVRKTQQTIYTACTLTAVNIIGLILLLVIPITHIKLIGFYLAWSYCSVYVLLITSVSNNVTGYTKKIFYNGVLMLFYTIGNAVGPLMMVRPPFIEGMLGYLVANCLVFVLFLVARWRMAVANSRRLLLMGHSSNVNMVPAHTYVQEDISDEQDQSFIYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQJ8</accession>
    <name>A0A367JQJ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000860">
        <property type="protein sequence ID" value="RCH92217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQJ8"/>
    <dbReference type="STRING" id="86630.A0A367JQJ8"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12214">
        <property type="entry name" value="ChiA1_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="371" mass="41816" checksum="3DAEE3ECCBE1EE2E" modified="2018-11-07" version="1">MFESHTTTTVYTSESTSEGGVQTSFSSSHSHTSATLSIHVATASNLVAAQRFGKQDPYLRFSLDFNNKEAFFKTFTHKDGGDSAVWNQSFTLPLNGEPDLYVEVVNEENTIDEVIGFCAIPINQIVHAPGANLNGLFDLYDLKGQRAGTVNIQFAALGFPNSQPADFSGQPVRGQSYVHEGHAARMKSSHNKATGVAVGAALLGGALAVGAGFLGKKMYDDHKEQEEQERLEEEEKQRLAQEEEERRNRERAEFEAERERFEAEKNERRNEEEHEKKECKPKKECKPKKCDDEKNKHHKKKCDDDEEEEHHRRRRNSCSDDDEDAKKWNPVGTYAAGDRVKYHGKVYVCLQGHTSNPTWTPDAAHSLWQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQT3</accession>
    <name>A0A367JQT3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000846">
        <property type="protein sequence ID" value="RCH92312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQT3"/>
    <dbReference type="STRING" id="86630.A0A367JQT3"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="360" mass="40160" checksum="40B41A8F512A3A62" modified="2018-11-07" version="1">MSAIGQAYPTISYIMVDQTDNMTRLYPQALLKQFTNLSVKPNWAYYDINAEFNSQVNWYFFNSSNPIRSDQIDLLRNVVHEFIHGLGFLSSWSDSFYAKLSPLVDGIDRFITPMLLTSVKESSATSYDAPQPFWGFVEFPFDKLIYANSSNALSPFTTVTYQLNQFYGSNVTFKSALDWANAWYASDAYKIASSAYSRTVSADNVLAVVNNVPTLLLETSLNPFSQGSSLCHVDQQTYVNSTEALMVYMADRGVSLNKTNRGPFGPKLIKVLAGLGYKINASFFNATTIRPELIYWMPPQGLVNTNQNPSPSLVSYTNGPAHAPITSTSSISVSHTSSCNHLIISSWLILLLLLFNVLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQY8</accession>
    <name>A0A367JQY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF2421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000851">
        <property type="protein sequence ID" value="RCH92279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQY8"/>
    <dbReference type="STRING" id="86630.A0A367JQY8"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="115"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="575"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="6">
        <location>
            <begin position="710"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="105268" checksum="4789036F7ABFE165" modified="2018-11-07" version="1">MDDIELSNQSTRHTENIQDRSVHGMIPEASKTSVLDRLKSIIPPLPLLRPMLKGSLAILIALIFVFVDRLRNAFGQGVILVPIGTILNFPFRPVAMYLANLARDPTINSPVQPNSSAILAIFLLISVFAITYLRVKNQQAFLASIFGSIILVFSITQASVTSGFQPVIIYTFLKPVAMSTAIALAVNLLIWPDDSMTKFMLMFTKSLKEYNEFFEEHAHNFLTLATSASTTTLPSLHTRLQGTILALIDSKREVQRGIMWSRLSQKDASTLTRIIKQMRTPLYGIGLSLLSKSDLLNKGELGSNGDEEKDTFIQTLADMKKLSQELTDTCIEALSECSARLIKFGDQPRTLKSTLLWPFPRIFLWNRSELKVPSNDSGLKERLDRLVDRYELEMKHGTLSFINSKTDVQNHFNSLFQIIYLFQFNLISHARNLQELLAFVQNLESTRTKKQLWFPRIGLRKWLSKTQRVDATLGGLTVNNVTSQNDMTLSRTMTAPNELERQEDLGLLGQKNKAGKVTYPRDPDVNPPETAFEKFFYSLYQIILWAQTVETGFAIKTASGFVLLSLPAFLPQSASWFFAWRGQWATVTLMMWMSPLAGMFLFGTVLRVIGTVAGGVLGIIVWEITRGNPYGLAVLMFILMIPLYYLFFTNKMLSPLVIMIQVTCILVVCYEYQYVTSGVAVYDSAEVVAGKRMLLVSIGVAAAAILSILPKPVTGRVELRKRISLTLHDISKLYGILVGDIISNYDNRIEQTPRLNKSLRKLFLDIRRQVADARSHLQLSKLEPPLRGKFPYETYAVLVEKVDNMADLLIGMAYAVKSIDRSWQRNLVSAMRDERTEYMAFIMGLMKLLSATMASKIALPPFIVSPNDIRDRFGKRLASEIVQCPGRLDNATFPNYCAFTMNAIYFVNELSVVLDCIKQLVGVEDPEQWIVLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRN9</accession>
    <name>A0A367JRN9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000804">
        <property type="protein sequence ID" value="RCH92607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRN9"/>
    <dbReference type="OrthoDB" id="2272123at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="8940" checksum="9EACEF435538074D" modified="2018-11-07" version="1">MNMSLCLYCEKQLLDESASFCSLACQINEASKPIHHILILFNRRNQFTLYRASSLHYHSHIMALPDANTRNNSPCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSG9</accession>
    <name>A0A367JSG9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000778">
        <property type="protein sequence ID" value="RCH92799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSG9"/>
    <dbReference type="OrthoDB" id="19659at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="9047" checksum="15B24CEC934DC45F" modified="2018-11-07" version="1" fragment="single">MSQTDISSSYTIQIQSTIDQLEHQLLTIKNESNNLAILIQKTRDASLLTEKELSEIKANMDMLSVYNNKLLSIKATMSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSZ7</accession>
    <name>A0A367JSZ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cu/Pi carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PIC2_3</name>
        <name evidence="13" type="ORF">CU097_007351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000745">
        <property type="protein sequence ID" value="RCH93070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSZ7"/>
    <dbReference type="STRING" id="86630.A0A367JSZ7"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="106"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH93070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="309" mass="34034" checksum="D8231616001653FE" modified="2018-11-07" version="1">MTIELYSTNYFLACTLGGILACGPTHSLVTPLDLVKCRNQVKPGLYKSVFDGWKTIAKSEGIGGVFTGVGPTAIGYSFQGAGKYGLYEVFKYRYANLVGEENAHKYRTLLYLGASASAEFFADIFLCPMEALKVKMQTTVPPFARTTGEGFKKIICTEGYLGFYKGIVPLWGRQVPYTMVKFASFERTVEFLYKTFLPKPKSEYNKLQQLGVSFSGGYIAGIFCALVSHPADVLVSKLNNLPKTEAGQKQVTAMDVVKQLGWKGLWTGLGPRIVMIGTLTGLQWLIYDTFKVYVGLPTTGGGEEQKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTM3</accession>
    <name>A0A367JTM3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hit protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HNT1_1</name>
        <name evidence="5" type="ORF">CU097_007774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000715">
        <property type="protein sequence ID" value="RCH93293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTM3"/>
    <dbReference type="STRING" id="86630.A0A367JTM3"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="159" mass="18345" checksum="7C2F5288E14DFF65" modified="2018-11-07" version="1">MTALFRPFTHTFKFSKRTMSTASQHLSDNCIFCKIIRHEIPSFKLVETDKSFAFMDIEPLSEGHALIIPKYHAEFMHQVPDEYLSEMMPIAKKIAAAGGYSQYNVLQNNGRLANQAVPHVHFHVIPKPDTETGLGIRWRPLEKTKDEIKARYESIMQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUC0</accession>
    <name>A0A367JUC0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000685">
        <property type="protein sequence ID" value="RCH93533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUC0"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="269" mass="29732" checksum="3A7EDEC26F09F986" modified="2018-11-07" version="1" fragment="single">MSFPRDSSNASLSNNTSHFSLYAESSSTRSADSPSLPRKHSDSTCSEPKFSFVPLRASHSHHHSRQSSLNQTDVQRDRSADSNDPFRLIRMAPNIIKMRKGSVLARNTILKMDHFSSGTNTNLDFHLQGAPNFRVADLNVYGVAQPTVIGLSTILAILNCHPKSSNSVSCTWFSTREEPLVYLNGIPYVLREFADPLQNMRAFLGINSVRLEKVEERLKSDVIKESRTLGGLILVHQELSDGTIVPCYIAADKVQTPKEGTGQGFKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUS5</accession>
    <name>A0A367JUS5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000667">
        <property type="protein sequence ID" value="RCH93690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUS5"/>
    <dbReference type="STRING" id="86630.A0A367JUS5"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="17716" checksum="971748D66B96043A" modified="2018-11-07" version="1">MLQNVRIKAAQCVSRRSLHMSRTLFEQSQIESIANQFKLSPNVLTQALTHKSFKHGNVPNNERLQYLGRRSLEYFAVDLNKSQNAQQLNQIIGKANESQHLVARFDALGLESAVRCQLPGNNVSPAVKSKVMQALVGAVYHEQGLNAAREFVKKTIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUZ2</accession>
    <name>A0A367JUZ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fe(2+) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRS3</name>
        <name evidence="10" type="synonym">4_3</name>
        <name evidence="10" type="ORF">CU097_009227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000664">
        <property type="protein sequence ID" value="RCH93715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUZ2"/>
    <dbReference type="STRING" id="86630.A0A367JUZ2"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="211"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="306" mass="33975" checksum="64B9023B5BF5128F" modified="2018-11-07" version="1">MQDIEYEYESLGANSTMTQNAIAGAMAGIGEHCIMYPVDSIRTRMQVLSVPELTTAITSRKQWIKQGNLWKGVYSVIAGAGPAHAVHFATYEFCKERFNRSIAYSTEVKLPNGDVLTIPSHLIASAGAGAIATFSHDFLLTPFDVIKQRMQIQGIKYTSVRECAKTVYRTEGLKAFYISFPTTLSMSIPFQSVQFATYEYCRSKLDPAGTYSPKTHVIAGAVAGAVASSVTTPLDVIKTLLQTRGTSIDPEVRDVRGFRQAARLIYSRYGIKGFFRGFRPRVLTNMPSTAISWSVYEYFKWFLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVC2</accession>
    <name>A0A367JVC2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000653">
        <property type="protein sequence ID" value="RCH93809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVC2"/>
    <dbReference type="STRING" id="86630.A0A367JVC2"/>
    <dbReference type="OrthoDB" id="2285422at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="88712" checksum="F48F6083471F1835" modified="2018-11-07" version="1">MPFDTVKRSNKRIRANLSSLHEDEDDDWYNTTIEIFNNQKNNFESSSFLENNYQSSITSSPPMDYIHTPSTIPIDIPYSNDPSDPHDSSSLDNITPPSSLCWQDDYFTGLSAASTVLSPSSPQPLDSFVDLSSINPHTADIFSKIQFSCTDKGINLEAKISNASDLRSLIDAFSHLCCTDKGVSSPTQAPQINNKIVLCRNKSNQTKPVNYFASTCDLGQIPNAHPTLDSPHSLREIADACIDTYFTCWVRFKPILKRDEFMAWYKAQERPTDTLIVNAICSYVFRHMVFHHPQPQFMHFLKDQDKLQEQEEYFFSCARECLAQSFDTPDRYTIAALLYMCVRAEPSRRHHYIGMAVSALHELEIYPRMAHEDADCYDKEMDTRLWWFVWAIDFYLWSAGAPKNTPQPRVPGEIDLPQVFEQDIDDTEIGVIAFIHCLTLWRIQADIVAALYDTENSELTIEQLVEYDKRLLSFYEGLPKYLQLDSGFEYGTGDLFMACLRVNIEYNATRIILHKLFIPEMHDPRPSQTSLDSLNICLSTALTQLSTIKTCNMVDVGRCAFDRDELWRAAEIVSVAMDIYQTCASSDDQARILRGIKMEDFHHGLIKSFDILRNTREFQFNAKNWLQVADWMQVEIRRHQLNTYRPATTEDTTAIKKPDFFLAHLKPHATLSPTLSHKQPQKSLKQPRRSISFQNQFTVSPQQQQQQHSRKSSFSTAPPFLQFNNYVPPSSQASSKVQPQFVNGGKSQARFRYFNPRKMNKFLFIDEHPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVX6</accession>
    <name>A0A367JVX6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000613">
        <property type="protein sequence ID" value="RCH94134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVX6"/>
    <dbReference type="OrthoDB" id="2367383at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="379" mass="40512" checksum="1AAF644C0DD076DA" modified="2018-11-07" version="1">MSSQKRQRSCPICDSEVLPYTINFDCQFIMCENLKCVYPFTQSDITDLLIEGPDTYKGYSIKKRIIPSTAANTAGVPAASVVHSEQSATDPRQGLIATKPSDSPLKQKEQLQLKALPIAKEATHTRVLHDTQNTQEHSSIGSRPIITPKSISKLATKPSPAYNNVTTSKDTGSNTAQLDVASLVKPVVHPQLVPTATKTLANASSTVSSDKSSSTAVLKAMPTTPVLASAKTSIFMPKTKSNAPKASTSLYIPKTKPKIVAPTTSSIYMPKAKPRADLNNTFSTGLVLPQTPTRSPTTSTSSQTSPKSVPDLCLDMNFDINDIEGLLTSDVGSISSAAPTPEGMSAMLKTALQQTEWLNDLQDIFTAPGVIESTYNPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXD1</accession>
    <name>A0A367JXD1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000561">
        <property type="protein sequence ID" value="RCH94593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXD1"/>
    <dbReference type="STRING" id="86630.A0A367JXD1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="572" mass="65584" checksum="296CCE89D1B5AFC4" modified="2018-11-07" version="1">MTTVQDLGLTTVANKEQFLDSVIIKECPGVGRSLVTKKPLTPGDVVLVEEPLIKYRLNPSCRSSNSPYYSKKLWNNIMWMVQSEEGYDEDKESVYSNSSTDSSYSDDSDDDNQTIQSDFCPGVPAAILAYLDLYPPFPVKNQRKYNKQDFEFFYYPNLDHPTVQLIRSVTQKVVDTEPLFSHVDPQDLCQFVLKIYANAHTVTIPSLRNEPTHSKRKARRLFYQSKFGESTSWGSDDRDTSSMPTIALLRWGSKFAHSCSPNMFLRYEPTKNVMIFTVIRPVKEGEVLSFSYLPEDDSTVGGLLCGSTEDRQAKLEKFKFFTCACERCSDWDWSRSVNCPACGHDCYPRLGQWKCFECERKYEDKEIEFLSNEQDVVQTVIGFITRVYGGRRLDQNTMSSLEPQLMDMLNGQVPKHHWTYGLIHSLLAAYHLQIFPQIYGKGLASQLGLTAKGIEEALVYIDFLNNVIFKHANPKSTSHGNPMTAFFASWKLLAIVIDLVMDNTVDKYANKESIMLIPLDKEWIEPLCKITDIIHSEWLPLIEQIFPSQRPVVIEDMIRQLQAFHDRVQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZF9</accession>
    <name>A0A367JZF9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000477">
        <property type="protein sequence ID" value="RCH95344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZF9"/>
    <dbReference type="OrthoDB" id="10300322at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="61767" checksum="A99E1C1DF3C7E5A9" modified="2018-11-07" version="1">MGIFKFYKKGNKNRQKTANSVDEISNKEKIFDDTPIYIPFALDSSTSGTTQSSLMDEIFKELPLSAYSKTDSNNDVPKSIRHSLTLGLRKNRVTSFNSSSNSIDLSGCSKSIETNSTLSEPENYSRKTSVFTDSSVSSDSTFSNPSSADERTSLNSVSVPMPPTSYMENQFDLQLQTQSNIKPSVARRSTTQIHSALSQSSTESILARMKERHRQERQKQHYWLPSYSIPVDRTAYFSPAVSQLILTQQAAIGHMQPYSMSQPVQPYFDPAIQSFSTQVPCAMTPTITPDAPCSPYYPYPTSVISSFTPNSSTSTPLSQLKGNPDSHYCHHHTKERELRSPSLYHPKYRTSRKTQQTDPAYSYNVASGVTESSIHSQYANHNDIKYVVTHPTNNCCKGTTKSIEYCRKSTCKKKKRMDPCLERLHTCHNVSLESQVNQKYREELDLMQKIHKRNCYSVSSCLHLLDKKHNVFEENDAAVIKVIQELKNSEEKTVRPLKAYCEQNQASIVITCCCHQSNNNSNRTRNGRQCHQASRIHANVCDPKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZU4</accession>
    <name>A0A367JZU4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000467">
        <property type="protein sequence ID" value="RCH95440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZU4"/>
    <dbReference type="STRING" id="86630.A0A367JZU4"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="257"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="338" mass="38789" checksum="99D8F4656A2DEA9D" modified="2018-11-07" version="1">MSEIITLLVKHVPDFITQSPELQKNYFKPYKPIATRFMQTASMPGFVFIDFANRHAAEEAYKELKKIHFGLYFKPIQVEYAKPDPSGQKELPSSTPSESPEPIAPLQGIDYPSNPHLRYLYPDPTPEILTNITHAIGSVPRLYTQVLHLMNKMNLPPPFGPLVKHAVPTLRKRKEDALLSSDESELEEETPQDTSKEQEERVKEARQARIAAEKQRLALKRAKENQQIQQIQRQCLPLEQLTHLAAFKNYEPGEVSNRLYIKNLHKKTTEQDLINIYSVFSNDIKVNLMTKGRLRDQAFVTLPDENVAKLALQSTNGYVLHDRPMAVVFSKNRDKVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K042</accession>
    <name>A0A367K042_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000458">
        <property type="protein sequence ID" value="RCH95515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K042"/>
    <dbReference type="OrthoDB" id="2208184at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10288" checksum="114965815E748FAB" modified="2018-11-07" version="1">MVIYKTILKIWKEQGCIVIGYARKSDIPLVKDDVRVKNIQSMIDILRERSGADEVYVSSCTNSTEPIASRDINVNQDMISSLHQCSGDAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K104</accession>
    <name>A0A367K104_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_013018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000425">
        <property type="protein sequence ID" value="RCH95866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K104"/>
    <dbReference type="STRING" id="86630.A0A367K104"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="383" mass="41755" checksum="6703D7E2B8448F1F" modified="2018-11-07" version="1">MSSGFGTRAVHAAQRPDPTTGAVIPALSLSTTYKQSAAGVHTGFEYSRSGNPNRNNFEEAMAELEGAKYGLAFASGSATTATIVNSLEKGAHLISVNDVYGGTYRYFTKVANKLGIEATFVNLSDPANIEKEFKPNTKLVWIETPTNPTLRVIDIKAIAERAHAHGARLVVDNTFMSPYFQNPISLGADIVVHSVTKYINGHSDVVMGVAVMNDKETYEQLKFMQNSLGAVPAPFDCFLARRGLMTLEVRMQRHAENAQAVAEYLETNQYVDEVIYPGLPSHPNHELAKKQQRGFGGMISFRMKGSLDNVNKFLQNLHHITLAESLGGVESLVEVPAIMTHGSVSAEDRAILGITDTLVRVSIGIENKEDLIADLKQALEKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1R6</accession>
    <name>A0A367K1R6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000402">
        <property type="protein sequence ID" value="RCH96095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1R6"/>
    <dbReference type="OrthoDB" id="2329895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1460.10">
        <property type="entry name" value="Nuclease A inhibitor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036587">
        <property type="entry name" value="NucleaseA_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82602">
        <property type="entry name" value="Nuclease A inhibitor (NuiA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19437" checksum="000C76EBF464A212" modified="2018-11-07" version="1">MTDNNDGEDAYMQMLNNPMINPPHSTKPQMTKESKLKPASFPIVEEVRNLLTSSAKNIYLESESDEPFEWINTKTTKTTLPTSIDELDDLDLLNGDEENHLEIKSYHDFLQDERYRPIKESLDKLKEKVDQESKVYLVGRNSITVLILTIVHHEQEHAIVGLKSLLVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K202</accession>
    <name>A0A367K202_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000392">
        <property type="protein sequence ID" value="RCH96198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K202"/>
    <dbReference type="OrthoDB" id="2239299at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11398" checksum="46E6AB9FD3D8EC82" modified="2018-11-07" version="1">MPSTTYNRSSSSASESELIHKQDALPLFSKDKQTFILPPPSSLPGYHLPLPPLLKQQQQQQHYDDVSTAAATLASFAYEDEMCSESQVIEAAKILMNISRCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2B9</accession>
    <name>A0A367K2B9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_005471</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000381">
        <property type="protein sequence ID" value="RCH96299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2B9"/>
    <dbReference type="STRING" id="86630.A0A367K2B9"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="17">
        <location>
            <begin position="645"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH96299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="750" mass="81583" checksum="77074B145B9D67DA" modified="2018-11-07" version="1">MRIPFFSTVAITAILIIYAWIKPTEHKINLRSWDEAYTMARTMVDRMSLEQKVNIATGVGWKNGPCVGNSYAISNPDFPSLCLQDAPLGVRFAYNVTSGVAGINAAASFDRNAIYERGVYMGQEFRGKGVHIQLGPAMNFMRSPEGGRGWESGGEDPFLMGVLAEQTVLGIQSQGVIATAKHYILNEQELHRTTGSSEADERTLHEIYLWPFARAIEAGVGSVMCSYNQVNGIFACENDYLLNTVLKGELGFKGFVQSDWSATMSTVDSANHGLDMTMPGDITMGSNDSYFGKNLTDAVRAKKVPESRVTDMATRIVAAWYKLGQDKGFPKTALDSFHLDKAPYINVQLDHYKLVRTMGAASTVLLKNSGILPLNKSIKNVAFVGSDAAVNPDDINACDDHGCNKGTLAQGWGSGTAFFPYLVDPITGLTGALGKDVKFTKSLDDWNLDAAVAAAKDADVAFVFSSANSGEEYIIVDGNVGDRNNLSLWNNGDNLIKAVADTNKNTVVVIHSVGPVLMPWIDHPNIKAVVWPGLPGQESGNSLADVVTGMVNPSGRLPYTIAKKASDYPLKPDPAHNVVYKEKLLMGYKWFDANNVTPLFPFGHGLSYTSFTYSGLTVKTVASGKSTKVSITVTIKNTGHLDGAEIPQLYLSFPESTNEPPKLLRGFEKVFIKAGKEKDVKFELTSTELSIWDTDSKSWVVPSGKFIAHVGASSRDIRQSTDFTLLPGVEKYVKGAALDRLVRLILSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3M9</accession>
    <name>A0A367K3M9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 UFM1-protein ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000340">
        <property type="protein sequence ID" value="RCH96745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3M9"/>
    <dbReference type="STRING" id="86630.A0A367K3M9"/>
    <dbReference type="OrthoDB" id="2281719at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="19206" checksum="BF7F566844E4EDFB" modified="2018-11-07" version="1">MTVPRDLFIQFIEQGLQKGLLPKDITRTLDGEYYLDPTFIQQTIVKHIEKEGKVTIEKLAKLLNIEQYVVAQVVEKSPDKTWTRVDDLIVTHNTTKHVQKELNKEGSLSIVSLSQSMKLPYNVLKLTLSAVQGYVQYPQLPDIIMTKDYVGRGKTRVEEALSAIEEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K403</accession>
    <name>A0A367K403_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA delta isomerase 1, peroxisomal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000329">
        <property type="protein sequence ID" value="RCH96875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K403"/>
    <dbReference type="STRING" id="86630.A0A367K403"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000049">
        <property type="entry name" value="Enoyl-CoA delta isomerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27372" checksum="597E2674BC32C65C" modified="2018-11-07" version="1">MVQFPVALPSKEVHYMTLDQEGPLFILYLHNKDNRFTTEFCQSIIKALTIIEGIFFEAENPVDMALVTVGQDRIYSNGLDLAHALANPLFIDTFMLMLRRMLTFCIPTVAAINGHAFAGGCMLSLAHDYRVMRSDKGFICMNEVDLPSALAPGMAALCRDKSTPVTFRKMILQGHRFTAQEALDHGLVDVVCPEKEVLPKAKELALKWAPKAKAGIVYKQLKEEMYTDIVRHLAVPFNRLASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4T9</accession>
    <name>A0A367K4T9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000302">
        <property type="protein sequence ID" value="RCH97169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4T9"/>
    <dbReference type="STRING" id="86630.A0A367K4T9"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7371" checksum="554421823A59931D" modified="2018-11-07" version="1">MNPTEAIQAHHDLGSPCISIGIHWGTFHLSNENYLSPPELLARLWAAQNTNGSQFITTSLGQLIDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5C0</accession>
    <name>A0A367K5C0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HMGCLL1</name>
        <name evidence="8" type="ORF">CU097_012653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000284">
        <property type="protein sequence ID" value="RCH97355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5C0"/>
    <dbReference type="STRING" id="86630.A0A367K5C0"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000201">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="340" mass="36427" checksum="D1B173028D0671AD" modified="2018-11-07" version="1">MYSMSRLSVANVAKSLLPLAMKRNFATAHRANGEFVKIVEVGPRDGLQNEKTLVPASVKIELIERLANNGLPVVEVTSFVSPKWVPQMGDNKEVFTSIQKKQGVGYPVLTPNLKGLEGAVASGAQEVALFTAVTESFNRKNTNCSTEESLKRAREITKKALDQNLKVRGYLSCVLGCPYEGPVNPEIVASMAKELYEAGCYEISLGDTIGVGTAGSMGTLLEHVLKVVPVDAVAVHCHDTYGQALANILKALEYGVRVVDSSVAGLGGCPYAPGAKGNVATEDVVYMLNGLGYKTNVDLDGLIETGQWISEKLGRPTSSRAGAALMLARKRKQELEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5I5</accession>
    <name>A0A367K5I5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000274">
        <property type="protein sequence ID" value="RCH97474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5I5"/>
    <dbReference type="STRING" id="86630.A0A367K5I5"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016652921" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15525" checksum="F543EC8A54C99A77" modified="2018-11-07" version="1">MSRSVSFIIFAILAFVALVYAAPIDSKYSSELEKRSSGMSGTFKGTGTWFLPATEGGSQGACGPEENNNSMIVAMNRPQYGSTSKKSKWCGKKLKIKGPKGTAYAKVNDACPECKKGDLDLTPIVFKKVIGDMNKGVGKITWSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5J2</accession>
    <name>A0A367K5J2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000280">
        <property type="protein sequence ID" value="RCH97409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5J2"/>
    <dbReference type="STRING" id="86630.A0A367K5J2"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="190" mass="22421" checksum="DD5655689697C025" modified="2018-11-07" version="1">MTDQSDQDGFTTVESFKYKKISKKKRNKYTFKDPDDYTIDDLEAKLKERREFLENSRFYKELLDIFKEHLLNSKFNDIVCYGIGSMQKSKNAQYQFILALILRDLLNIPGKMYIFDPVMTELDKELCTIYKLDIIQENEQGKRAVEQSTLFYMPHCGRGLYSNTLSANWTARQLPLITIIGNRFDMYVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5N4</accession>
    <name>A0A367K5N4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000270">
        <property type="protein sequence ID" value="RCH97524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5N4"/>
    <dbReference type="OrthoDB" id="2355659at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="23174" checksum="A8F1DF7A63D4A2BD" modified="2018-11-07" version="1">MLSHCCFCINLKTATLLLAVLGTISHLYGALTLTALSDEFEDADMGAVFGLTAYSYLSGFACLAGAIGVIKNNVKHLKFFSIYYWADLVLHTFFSVASAVLLFSLDHEICKEIVSEVKDDELDMNTCESIYISSAWIVTLAMAINMLLKLHFAFAIHSYTHRVQQETSMDTIEERVIVAPYPAAQISKEQPIFVAGQEFIPDEKKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6N1</accession>
    <name>A0A367K6N1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS5_2</name>
        <name evidence="6" type="ORF">CU097_011697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000245">
        <property type="protein sequence ID" value="RCH97825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6N1"/>
    <dbReference type="STRING" id="86630.A0A367K6N1"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="22684" checksum="F787485C7F825B11" modified="2018-11-07" version="1">MVALNLPADVLATADGSRKLFNKWSYEDVEVKDISLQDYIQIRQHVFLPHTAGRFAVKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAARIVQHAFEIIHLLTDANPLQILVDAIINCGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAISLLTIGAREAAFRNIKTIAECLADELINAAKGSANSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6U5</accession>
    <name>A0A367K6U5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Angiogenic factor with G patch and FHA domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AGGF1</name>
        <name evidence="3" type="ORF">CU097_010569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000241">
        <property type="protein sequence ID" value="RCH97876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6U5"/>
    <dbReference type="STRING" id="86630.A0A367K6U5"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="34561" checksum="323B18F01C12EDBB" modified="2018-11-07" version="1">MSQDASNEEQWTFDDFFNVYVMHNKKRVMYHNGQVWVNGDYDSFYTTQHNAISTESIRLVILSSPFYRAGQVVLVDENGLTMGRDRSWDRRLRLPELAVSKFHCHIFLNPTTELFYLVDVGSQHGTRVNGELLSEAKKSSLPYLLKHKDIIEIGSTTLQVHKHPICSECRAKEVIDVCAGKKEKKKKEGMQSLEVDRHEWIKQYKEKYDISSHAVQDDYVDRAELRRQGIESDMAPPKVIPPKNNLALPEPIIRVEGVGSNMLKKLGWQEGQGLGKDSHGIKEPIELATQIDRAGLGMKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K772</accession>
    <name>A0A367K772_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000230">
        <property type="protein sequence ID" value="RCH98018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K772"/>
    <dbReference type="STRING" id="86630.A0A367K772"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="254" mass="28420" checksum="337C3560F7861A02" modified="2018-11-07" version="1">MRKKTITAACCVIGDEILSGKTQDANSHYLAKTLFDLGIELKCIQVIGDNKQDIINSVRELSSTYDIVFTSGGIGPTHDDITYESIASAYGLQLKTDKDTLEFFKRQAEKRNMKWTKSHVRMATFPYPAELLREKKGIPFPVVVVNKNIHVLPGVPMLFKILLDSLKPRLAVISGSRFYRCEIATRKTEVSIAEVLADIQARSDDAKIGSYPFGKNQDGIQVVITVSGKEQSKVDNITREIMEKTEGWLYNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7L3</accession>
    <name>A0A367K7L3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000218">
        <property type="protein sequence ID" value="RCH98165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7L3"/>
    <dbReference type="STRING" id="86630.A0A367K7L3"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="21996" checksum="084A02DBABADB23B" modified="2018-11-07" version="1">MQQTSTELDFIHAYLDRLSVKSVRYGQDYLTHTVPTLRIKRQPVVHKVSSESDSSPATTATTTTESSDKFQLNIKVLKPSFQFSIGGLQSNDTVSHLKQRIYQQQSAYPVNRQRLLVKGKVLGDQKTLGELGLEGDSVVHLMLTAAPASKTGRFGISAEAEQKMNSPEFWETIEKTLVDQLGQADATLVFSKVKAALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7L9</accession>
    <name>A0A367K7L9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000218">
        <property type="protein sequence ID" value="RCH98168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7L9"/>
    <dbReference type="STRING" id="86630.A0A367K7L9"/>
    <dbReference type="OrthoDB" id="2248794at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="16667" checksum="C3F816CE32958E1E" modified="2018-11-07" version="1">MKVKLDALTQILFSRRYSVILIKEGTYSVLESSSKQPDFGGNVLENSNWVGPVLVEEVKGEDRKDDMYMYLMDLYRISSLSVESINQNRYKGVVGIQMIGMQATFYVSTFLSKGFYVMTEICSITLSKDLTKILSYFANVSDLLPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7P3</accession>
    <name>A0A367K7P3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor of the MADS box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MCM1_5</name>
        <name evidence="8" type="ORF">CU097_014068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000216">
        <property type="protein sequence ID" value="RCH98195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7P3"/>
    <dbReference type="STRING" id="86630.A0A367K7P3"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="29507" checksum="6D47423434CD0356" modified="2018-11-07" version="1">MSHDMNNSKMFETEDPANDSGNDSDSEKPARRSGRRKIKIEYIEDKNRRHITFSKRKAGIMKKAYELSTLTGTQVLLLVVSETGLVYTFTTVKLQPIVTKPEGKNLIQACLNAPDPSEPSTSGDASYSNTSPQVNDAKSKFEDTKPEPPKQELTQPPNTRYGVGGGAPGYASSQYAPGAPNTNNTGSHLPYNYPTYQQSSQQQPSQYGMQQPFYGNQQPHYMSSQQQQPGYWQQQQQQPQQQQPPNTNPQATLTKQEEDKSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8S1</accession>
    <name>A0A367K8S1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_013195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000187">
        <property type="protein sequence ID" value="RCH98567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8S1"/>
    <dbReference type="STRING" id="86630.A0A367K8S1"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF2">
        <property type="entry name" value="OS02G0536400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="37231" checksum="1C2CADEEFE7F864B" modified="2018-11-07" version="1">MSHYDRERDYDNSRPRDIDKPNPCRLYVGNVSRYVREKDLRNLFSRYGRIRDLILRNFYAFVEYDDVRDAEDATKELNGYKLEGERIIVHVANVARSRLNRTRDREDRDRDSRRRDDSRERDHDYRSSRKGADSNDPDRCYNCGEFGKENDYMNVNNRLTIKHSGERAMRFQKGVCFECGETGHRARDCPDRRNGSHRRRRSRSRSVGKRSRSRSERRSRSDSPARRSRSRSPVRRSRRSRSPRRSPSPRRRSDRSFSRSRSNSGNRAQSNSPKRRRSDSRTVSPKRRRSYSSHSRRSNSRESVKEKDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K920</accession>
    <name>A0A367K920_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000179">
        <property type="protein sequence ID" value="RCH98667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K920"/>
    <dbReference type="STRING" id="86630.A0A367K920"/>
    <dbReference type="OrthoDB" id="2393255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="44967" checksum="2B3AB2257E743B41" modified="2018-11-07" version="1">MFHSSGLRHEQYLIRSKQDSKHTLHKKRSSLESEISAGADSGYTSSSFTPTCSINKKPHITGPPKKKKRYHQTPRQPDLVYSCPRPLAFPFHNDDHFLPIAEADPRDVARVSPPSINRASSIQSKSTTSISRHDADSSYSRRSSVLSSIQRGTVRSIRSLFQLPDSLSNLSQRTTQTSIITTDPPLERLEIKKGTVQSLKDFFSKRQPPQTSSSIVSPASPKRGQLGTTIGSIQTNKTTNDSRASLKKNSNSSSSSCTKLSSNPSSKKSFTSRASEFASRAFWKKPAESTTPCSAKQPNVSTTPRVDRSAAQKPLPEPPKKKTIKSEVKKISARVISSFRPTPNADKIDKPSKPSLFSFKKNNNDELLKKKPSTAATTIPEEPSKVGKLWKSFKNLMTGKKSSRVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA95</accession>
    <name>A0A367KA95_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000146">
        <property type="protein sequence ID" value="RCH99108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA95"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="100" mass="10834" checksum="1BA7E33485AE03F2" modified="2018-11-07" version="1">MDKKQHSNVGDVDDLPPPSYEEVINPPFNPNYSASSSNAQSQPQPPISRPIYPQLPSPPPAVQHHQPSSFFLAGFARPCGYLVPAVVQVVETNMKLGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAH1</accession>
    <name>A0A367KAH1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_008365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000136">
        <property type="protein sequence ID" value="RCH99243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAH1"/>
    <dbReference type="STRING" id="86630.A0A367KAH1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="425" mass="48237" checksum="3776936B68DC54CF" modified="2018-11-07" version="1">MAPILLKVKGNTESLPFGNLDSPDDLSKTWRVCTKVKDSLENGSRLENLSWRLWFAHNVNQKKKKFASPAVSFKIPDDFDFNRKKKKKTIQEKEIEYRRNLKLQQQKQAQHILQEQFTLQKFTSDQAGDQVIELDDIFKNYLIPSTTPPHPQQQSHQRQHPSTQQQQQQQQQQQQQQQLNSESLMHQNWPIEDYSLSCMQNYSQQQAYCNQSSALYVSAETMPPIPIGTLHNRLLATLPRETLESAERLLLSSTDNEMLMQSSQQPCFIQSTPSTPFLSFSSSSSSSFVHQPQLSQLSQQQQHLAPQQQLPQRLPQQLSQPSVLLNQNSYHSYTQSSLTVNTETADSIPYQSKSLPSSRAPSPTSHSPSPSSPLSVKKNSYQKRGLIHSSPADGKIPICSNCSTTTTPLWRRSADDELLCNACGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB92</accession>
    <name>A0A367KB92_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000124">
        <property type="protein sequence ID" value="RCH99437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB92"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="74" mass="7488" checksum="EE5810DEA634B27E" modified="2018-11-07" version="1">MGVLGGCIAFEDDVGLFEIGLDADVGLGFGCTPFDVVGGAADVGLGFGCTPFDVVGGATVDGWIRFFFTSFVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBD2</accession>
    <name>A0A367KBD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_015059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000121">
        <property type="protein sequence ID" value="RCH99477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBD2"/>
    <dbReference type="STRING" id="86630.A0A367KBD2"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040797">
        <property type="entry name" value="ZMIZ1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18028">
        <property type="entry name" value="Zmiz1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="7">
        <location>
            <begin position="745"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="904" mass="101006" checksum="330B26DE795560A0" modified="2018-11-07" version="1">MNNDLTTSAHQSINNSLTGSHNQPDHISNNNNNNVLSVRHIETVYQDRNTIRLAQIEEELRKISSYGSACDELLVWINDNRAYNSHYEAALLKCFRAIYETAESFGAWSGLQILKKASENRANLSLISQKLIEELYEGLKVKVLNKKKESTSMANPTTSTANSPTAAPLNSTSSGPSTPTTPALAQPQQLELSTSKNYDDLVREILASVCEPATGTAQKDACVNQPNQSTSIQNDSSPTATTVAATARSQQRVLSQSPVQASFATRSHPAIFINQGQPVVAPLTSHYSTLSAPILQQQQMAWLQYQQMLLQQQAQQQAQQQAQQQAQQLTLQQFQQRLQQKAQQLQQQAPRLNKINSIKQYMVPASPTKQGSPQLQRTNEYGQTVQSPTNQSGASFSSLPQSISSPTIVQQQTAAQNAQATQYTYNSNQIAAWQQLMQQQQQQQQQQEQEQRLRKYYNQQLLAAAVQMPQRGMQQRVQNAFIPQQMSPDYQSPQQQQFNNNNNISNQQQQPSAPVYIQPTQAQSQLSNTVGNSNTLQKQAQQSQQQSSSVSLAEIQAVSTAAMLPTTTDLFIPARLTNGSNSSTSPTQPRPAQASTSNFGQQNAVYLPNITQPSFDQLVLPNKTTGLIPALANDSDPKDLADFLRPSSAILGPFRLVHSQRVTEKQFFIGKNYFTSLFNETNNREGTNVLRIYQDDCACSFNFCIRLYVRESENYIVEKVRKTPLSVQRGKEAIDKLLGKKGGSDDDEIVIEQKTLRVSLKCPITLTRIKIPAKGIKCKHVDCFDLHDYLLLNKMERPMWTCPHCNDVVTSEQLGYDLFFEGLLKTLPKNVSEIEFKDNHSTITVTKEDDLDDDNSNSEDEDGSMDNKAIIQSNIQKVEQNVDVIDLISDDEEDTNTHKRLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBV6</accession>
    <name>A0A367KBV6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ERAD-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000104">
        <property type="protein sequence ID" value="RCH99714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBV6"/>
    <dbReference type="STRING" id="86630.A0A367KBV6"/>
    <dbReference type="OrthoDB" id="2235346at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="78606" checksum="4D8B343928391E54" modified="2018-11-07" version="1">MIKEADLLYTPRSEAHYSKACVNHIDTFTKDDEEVLDSNTVDDLSVTITSDLSYTMDEPITADMLLFENADIPVNIVDCKGFIVDLFQETPSSVDARGHQKRCSIVMKLIDDYYYLHGGYSEAMQWYIGSIKKGNVNAMKAAGWMHLLGEGVIMNRHKAIQFFQQAAGKKDLDSTHILQLVGQHNNSYDMELGSAVEQCLQDSAEDRMNDIGCTYRFKRNYEEARQWYLKACKRDHDESMVDMYLDDFGASKNYTEAVLWYKKAIEEGNSAAMNNIGNLYCNGEYLSQNYEAAMQRYQYAAIRGNVDAMFNMGWIYYHVIPNYEKAMIWYKIAARRGHANSMCNICDMYFYGEYKTQDYKKALKWYKKAARNNCNNAIYNIGCMYHRGETASVTNSRDKNLNYNYKKAMMCYLKAAKAGNSSAMNQISFMYRSGDGVACDYAKAMMWFLKVAEKDCSNSMYDIIPADQVKQEFEKAKGFYTTGGNYHATDSVICRQRVHKTVENEWTRTIHWFKLAAEKGNSDAMFNIGCMYRDGKGVDKDNEIAMDWFNKVAERSHINAMFSLICIYKYIKKDEEIADDWFKLAVDRICGWNMNRLGCLYRDGDGVEKNNKKAKEWFFKAYENGNVDAIYNIGGMYRDGKAIKKDYQTAMGWFLEAAKEGSSCAMYNICCMYQHGKAVVKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCE5</accession>
    <name>A0A367KCE5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coatomer subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COP1_1</name>
        <name evidence="5" type="ORF">CU097_001355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000091">
        <property type="protein sequence ID" value="RCH99912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCE5"/>
    <dbReference type="STRING" id="86630.A0A367KCE5"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF6">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_30, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="487" mass="54957" checksum="6AB2C4914AA2C067" modified="2018-11-07" version="1" fragment="single">TIKNLMLQNRYIVADLDILVNRQSSTSPSSIAGPSSSSSPLATPVSNNQRRRKRKFAASTSFDIVDLTRRDDEQQLVDQSTEEVENDENRSTSRARSVFEDVNISAPNENPVVSRMDERFSDLRSLYYCMMNPPNSADLDEDERHSQLEVFSSHLYEIARYGSFDVLDTLHYSDTSHSTSIVSSIEFDKDEEFFAVGGILKDIKIYDFRMTCRPGESRTMMHCPVRRIACENKISCVAWSPYIKGQIASSDYLGVISVWDVGTGQKTASFAEHRKRAWSVDICQTNPSWLASGSDDTTVKVWSLNSPRSIFTLPHKGNICCAKFAPNNQNYLAVGTADHNIICYDLRNPTLPLYTYHGHQKAVSYVKWLNDNELVSASTDNSIKLWERETVTCMRTFTGHLNEKNFVGLSVNENWIACGSETNTVYAYHKHAQAPIAKYTFPIDAIPTRMMLDSDPAYFVSSVCWKKDTSKLLSANSKGVVRVLQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDD3</accession>
    <name>A0A367KDD3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CDA2_6</name>
        <name evidence="6" type="ORF">CU097_007318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000071">
        <property type="protein sequence ID" value="RCI00244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDD3"/>
    <dbReference type="STRING" id="86630.A0A367KDD3"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017009355" evidence="4">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="5">
        <location>
            <begin position="108"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="404" mass="42884" checksum="7711ED0B9390434B" modified="2018-11-07" version="1">MYQQLFVLASVALAIVNAHPGAHTSGTKTTTTPSTFKFTETFPEPGSVPTPKPEWLELIKNANVTNAPVYKVGDGEGPKPEVEGQDPYCDWTFTGCFGKDDLYQCPKGQWALTYDDGPSEFSPKLYDYLDKINVKATFFMVGGQVVKFPEYALRAYKSGHEIAMHTWSHSYMTSLTNEQIVAELKWNELAIKEVTGVAPKYFRPPYGDIDNRVRDVAAALGFIPVIWNHDTNDWAAASNPQSFKESWIDGNVTKWAQEAKHAKVGGISLEHDLYEKTVDAAIRITPTLQKAYTLVPVGVCNNVTMYKDNATVPTNTTTSTTTADAPGTTTIRLDSNAPAADAAAPAAPAAPAADAAPAAPAADAAPAGNQPIAANIASTSGASSVSSSAVGLGVAAAAAALVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDP9</accession>
    <name>A0A367KDP9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000072">
        <property type="protein sequence ID" value="RCI00230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDP9"/>
    <dbReference type="STRING" id="86630.A0A367KDP9"/>
    <dbReference type="OrthoDB" id="2387105at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016759825" evidence="1">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="525" mass="60142" checksum="1295D87489732345" modified="2018-11-07" version="1">MQILSYSVCLFLTASLVQARVVQFNVISPGSKTVQVKVNGKVGNLQPVSPDVPLYTGAFEIGHESVYTYIADSEPEEFKRKLDPKTNKTLNEFFGRPITYASIPPLPRPLDNGKQWTRADKNPDLFDTNYIPTVFVQGDPEDMDTLVSTVPKQKFKVTLTMVGKDYYRTFHDVKFSITGAGKRHNPAKQSWRWTFADGDFINHRNNFKIRNMEEDPTQMREKLYADCLRAMGTYANQANMVRLFINGRGYGTFNMLDDIPKYSYIRANFYAGHPPEQMGPLYNGATGASFDVLSPNEYTMFKPSKDSPEDADAILELAKAFDELDLSNDKDIAEFDNNVFDVDQFLRFMVMEYLAGHWDGYWMEQTNDGAYKDYANNNKWYYLGQDYDATFGVNLSKDVLKVSYKDYPTRYPGGTFINGFLENKKLHARFESYLVETVKTLFNNRTLGEHIVAYHQFLAPDLEWDRSIKQLSPGINFGWSFKQTYENLFKKVNSPNHNGGGADYGLTEWIDKKSKFVAKDLGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE11</accession>
    <name>A0A367KE11_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000058">
        <property type="protein sequence ID" value="RCI00473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE11"/>
    <dbReference type="STRING" id="86630.A0A367KE11"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016595641" description="Phospholipase B1, membrane-associated" evidence="1">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41678" checksum="8BF6DB55EC5F8F74" modified="2018-11-07" version="1">MVQFKLLALPLLVAVGTVFANVQSISDCPALPPRKSPPKDVTDLRPDDIKVVAALGDSIMAGFAMMGVNYGAHGTGIVNFTSIMEFRGNSYGIGGDTDAVTLANFVKHYSPNVKGASRLAHIVSYCSAKECTIPESFYRPLIDNLNGAQSGAIAMNLDYELDYLIPRMKSYFKKDEDFKKAWKFITIQIGSNDQCDACSASEKSKYVTPELYGKYVNAALQRIQKEIPRVVVNLLGTFKVSNVLRLTAGHHDYCPPNGILENTKECACGTSEEGLKAMDATSEAYNKQLEKIAAKYPGKPGGSFAVMYSPAPIDILSFPIDAISNIDCFHPSLKGHQWIAKNFWNQIFLSKDKKPKHMKFDDKLKIYCPTENDRFPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE79</accession>
    <name>A0A367KE79_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000060">
        <property type="protein sequence ID" value="RCI00441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KE79"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="3">
        <location>
            <begin position="1415"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="797"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1524" mass="170642" checksum="109591AC0F31FD22" modified="2018-11-07" version="1">MASQQNVSKSSRPISFVGMNVNQVKSELAAQLSNQEQLLAKLGTSQISRNAFLKQSDMIRKELQDLNKYNQQDELPTEIREKLETLANEFQHIKATKSSDTVSPLLPPAPTHSSSSKQRAKYANGNKRNPDIEFATEIGQGLLIEVRKLQSIIQEKEEIIKQLEAAKRENERHHETAQRHLKQREEIEERLKEENWNLEVANQELRTHLLESNQTIAKHNAEYARLVKQIKNQSEQIDIMKAQEEKNTSLIEAMKARHEQETHQLRKHAANAQRENAQIQKQIEALNTELKICKAKLAIKMATASARSEEPSESSEAAADKNDQDSDHSVKDVHPTSSTSTTTNRSQQLETETLKQSLAHAHRIISNLRSTAHKEKLEKFELKKMLSDSQETIEQLRKDIANMSNNAISINGSRSNTKTAKKKHTKKRRGGVARQARGVSINDSSDSDQQSIKSSDSELDDSMDEQQDPQFNNGLGLGFGMPISALPMKPLSSELEFKVQVIDVGINTDPIDIVAHEKPSDSLSSVSLSTHSVAPVTSNGKAVDVTTVPQLSETSFITDAREVTLEHTTDNQPSLDTNDIPKTAEKPQVIVQEQIKHVVLRELQTASARAAIILPQEQMTLLIKEKVFVPTESSFSQLPTLDSHQQTSINVDPTADVQPRADLISLEEAKKMVKEALEKSQVEVQQTMISKTEVDKLITEALEKSAAATKQDMVPKAAVDQLIAEAIEKAVLSEREEMQSRMIEREKVEEMMKTMVERQEVEEMMKTMVEREKVEEMMKTMVEREKVEEMMKTMVPRSTVDQLIAKATEEAIQLEQQKRADEVSGYLVQPSRQQDEEIITKRQADMLVYEAVENAISAERQRVAAEKDNEPSRKDTKPRIVFSEGHESVIDIAPTDHHEAAEKQLTEIKSIHISEQSAIAEEKENEPKEDMIAQSQVDKLIAEATEKALLLERQKISSTMVLKEEAEKMAVEASTKALEEAKREMQKKIDQDMISKSNVDTLIEQAKQSVRAELDVILKEAQIAATKDMITKSEAETMALEAVEKERSNMISKEEAQGLVTQAVAKETERLLNEHQQALETALAEAEAAKSAEKESLLKTIESYKKECDDLNQRMKHMLTKDSTDVLIKRAVADALKTAEKKQKEMLANMISKVDADILIQQAVSRALEQERKEVAEREATETVEMISKAEAEALAKVAAADAIVKERQAQAAREKELITKEEADTLLQQAAETMVAEAVHNALEKEKKARAEQNTKPNTSVPSKHSQLSHSPLAIERSISTSRLAPPSSQVSPSPSVSTPPATSRHKLRLSSSVSSLRRKASADHGSSKKEPHSRQSTESHRNFGTLRIFESTTYGSRKLSSRSNLRNIANQESATSISTISSEDAQPYLPPSARSDDNLAAFANHEGTTDLEVITAITKTMIGEWLLKHTRRYVGGGISENKHRRFFWVHPYTKTLYWSSIEPGIDGSESKAKSAFIEAVVQVPSNNNQEASPMSLLIRTPKRDLKLTAPTLERHEIWFKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEG2</accession>
    <name>A0A367KEG2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="3">1.1.1.271</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TSTA3</name>
        <name evidence="8" type="ORF">CU097_008923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000050">
        <property type="protein sequence ID" value="RCI00605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEG2"/>
    <dbReference type="STRING" id="86630.A0A367KEG2"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="37112" checksum="2C104FFE695A43F9" modified="2018-11-07" version="1">MATESVILVTGGTGLVGEAIKWVIENEKSERFGKREGETWIFLSSKDGDLRKEEDVKAIFDKYKPTHVIHLAAMVGGLFKNMKYKLDFLRDNMLINEHVLWQSKEHNVKKVVSCLSTCIFPDKTTYPIDETMVHNGPPHDSNFGYAHGKRMIDVYNRAYYEQYGCHFTSVIPTNIFGPHDNYELEGSHVLPGLTHKCYLAKKNGTPFVVWGSGKPLRQFIYSRDLAKLFVWALREYEEIDPIILSVGEEDEVSIKDVADAIVKALDFKGEYKFDTTKADGQYKKTASNAKLMKYLPDFQFTPFETAIKESVDWFVENYDRCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFI9</accession>
    <name>A0A367KFI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ARO7</name>
        <name evidence="15" type="ORF">CU097_013284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="PJQL01000035">
        <property type="protein sequence ID" value="RCI00890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFI9"/>
    <dbReference type="STRING" id="86630.A0A367KFI9"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="134"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI00890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="263" mass="30152" checksum="BD43C0C07B66311E" modified="2018-11-07" version="1">MTVDTYSLDKLRSTLIRLEDTIIFALIERAQFALNQCVYERGALEFNGATGEKSFLEYFFWETEKVHAKVRRYTSPDEYAFTSPLPDPILPPLQYDEFLYPNDINVNSQIMDIYIKDILPVICKKGDDMNYGSSATKDIEALQALSKRIHFGKFIAESKFRSNPSEYIKLALAEDREKIDELLTNKQVEAKVLERLHRKALVYGQTLDEEQEGTSKHLRIPVELVVNLYKQWVIPLTKQVEVDYLIIRGKAAAAAAAACQMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGY3</accession>
    <name>A0A367KGY3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-dehydrosphinganine reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000008">
        <property type="protein sequence ID" value="RCI01485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGY3"/>
    <dbReference type="STRING" id="86630.A0A367KGY3"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016833998" description="3-dehydrosphinganine reductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34215" checksum="B25000BE05158066" modified="2018-11-07" version="1">MSLLVSTFFWIGVLAVVPYLALVAYGAYGCSEQNLKQKYNAQWALVTGGSSGIGAAIVRKFATQGLNVVVVALDDAVLTKFKETIVKEFPRVQFRFVGCDLSEASGKVYLEAVKKATHDIDVQILCNNAGFITTGGYADVALEREMANFHTNVTSGLVLTHHFVDEMLNKGLKGLVTFTSSSAGFIPNPMSALYASSKIFLTTFAASLAAEVAEAKIDVLAIHPSPINSSFYNNAGKMSALLTAQKFSSPPSVIADTICRNAGKIVIVDQGPITVIMKILMTKVMDWNVFTEIMKLGLRFNGDYKAMKVTRPMKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL42</accession>
    <name>A0A367IL42_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxyacid-oxoacid transhydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ADHFE1_2</name>
        <name evidence="3" type="ORF">CU097_001310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005201">
        <property type="protein sequence ID" value="RCH78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL42"/>
    <dbReference type="STRING" id="86630.A0A367IL42"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="177" mass="18963" checksum="E8AC1EEFEBF53E9F" modified="2018-11-07" version="1" fragment="single">MAAAASRSNVTRLLKVIQSGANSCPCHSHAHSTPATAGTFSSLLKYGRQYASAAETTDYAFEMAASNIRFGPGVTSEIGMDLNNLKAKKVAVYTDSTIAQLHPLKAVVESLEKHKVNYVVYDTCRVEPTDTSFKQAIDFARKHDPDAFVAVGGGSVIDTTKAASLYSAHPEADFLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILS9</accession>
    <name>A0A367ILS9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005012">
        <property type="protein sequence ID" value="RCH78642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILS9"/>
    <dbReference type="STRING" id="86630.A0A367ILS9"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH78642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="26132" checksum="B8F99C8D9E5FA2D8" modified="2018-11-07" version="1" fragment="single">ITTNFGHEPFMFDIEQYIKDQKVLSIQQMTSRQSIDRTPYTEYDLNQLVLSYLIHHGYTKTAFAFVKNTKSISDTDQEDTVTVRGTGMEQRTAIRSAIIRGDIDDAIRLIQQHFPKLLDQGERGKSVQLMLKCGKFVEMMREYCEHTHKKNGKSPFECNEFGELPKPSKQKRRLSYAEIASSINQKKDVNLEGSKHTKHEHSETQAHMMDIDEKSEKDVSAESLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPY0</accession>
    <name>A0A367IPY0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004315">
        <property type="protein sequence ID" value="RCH79738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPY0"/>
    <dbReference type="STRING" id="86630.A0A367IPY0"/>
    <dbReference type="OrthoDB" id="2216267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016968419" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH79738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="18847" checksum="0D67BE64E2104166" modified="2018-11-07" version="1">MKLFVISSAALSVLGLVQALDQPHCRKTYEVVNGDSCQSIASKHSITKDHLSEWTKKINMNFDCDKIKPGEVICLDYESPIEKRSPKKAHVKKPAHPKKHTTTKKPVHRKKHAKSKKVAHDKDKREVKEPVDHKKKPSHSKKHAAKPVHPKKHTTKPAHPKKLARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUM3</accession>
    <name>A0A367IUM3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003456">
        <property type="protein sequence ID" value="RCH81393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUM3"/>
    <dbReference type="STRING" id="86630.A0A367IUM3"/>
    <dbReference type="OrthoDB" id="2207231at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="397" mass="44887" checksum="F0D3E7461CBEA283" modified="2018-11-07" version="1" fragment="single">MGITLLVNPECPYPVTHFPSSSPYVLSCQVASLLIHCVYLPPSTLSDTEALDILRSLPTQTHPSQSNTIICGDINARHQLLLGDTRTTTRGTLLQEWLEDSGHTCWNSSLAYGVPTYSSQSRVHHQSGVQFKSVIDLFISTQDLVNPTLIVREDLNMGSDHHPVSLTCLLPTPPPTHSRKLWNLSRLTEEDCTYVSIFSDRILPFHVRLLTFFDPHSQSSFQKPNLDALAAELTGIIHSSLDDSVGRKTPKQSNNSWFWTPLLQDAFDHREHCRREWHRAVGIEKCQAWDRYQLACRHFNRDMKRRRRETWRQFCNKLSSGPLQETASIVRRVKRNRTITPTFNHPDGPQVAADTMANHLKQVFSGASLPASHYPAPPIPSGPHEIDLSTCPFTEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVQ8</accession>
    <name>A0A367IVQ8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003289">
        <property type="protein sequence ID" value="RCH81768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVQ8"/>
    <dbReference type="STRING" id="86630.A0A367IVQ8"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="497" mass="55619" checksum="2A94898AE19D5B90" modified="2018-11-07" version="1" fragment="single">DHLFDISAIQNKIVYQDIHAQLEEWEVLEESDAVPYLPARTEPVNVKVGIEEKTSVRLDLFGSIQLANHFKYKKGYVLNTGGNTWGLDFVPKVESRDTSPFIQYLAVAGYRGASEERIGLNEEQPTGTYKNCVQLWKLKLSVKQEPEEPLLDVCILHDFGAVYDIKWCPYGVYEEVLEGAANGLPKLGILAMACGDGTIRTLVVPHPDALRASLKLNHNTVYLRVKSSRCTFAATNSKPLTIQWGGHKKLASGGTGNDMSIWNMESALTQPTTRYGQHLIFSYVVLDSPSKCITWRGQEDPYHVIVCGFDGRIQVIDIRDPCIPFTFMRSRGPVYAACWVGHAPMLLVAGSEDSVRGMTYYPGLTPCLTKYGNLPGPCWYLGTSEHHGQFLMATATGWLASANMYQYKGRVASLYHYYIYKLCYSEETNTYIYIDGIGFKSQEEIAKTPQYELFTVGEVSLQRAVWNPNRRTAGFIASAGSAGLCRIEFEGRGSKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVX3</accession>
    <name>A0A367IVX3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003263">
        <property type="protein sequence ID" value="RCH81827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVX3"/>
    <dbReference type="OrthoDB" id="2270846at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="95" mass="10978" checksum="F3D43BD6F561FAD5" modified="2018-11-07" version="1" fragment="single">VHMMGETALIQNTVENDHSEVATDSSDVLQSEVLSDAGDRTDECIKNQDVQVEYTASYVVIKKETSLKKKRATQYNVYTDEDRRRYFHFLAEKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX98</accession>
    <name>A0A367IX98_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003066">
        <property type="protein sequence ID" value="RCH82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX98"/>
    <dbReference type="STRING" id="86630.A0A367IX98"/>
    <dbReference type="OrthoDB" id="10676418at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="15420" checksum="0ED423330098E30C" modified="2018-11-07" version="1">MRSRKVLNRVLIILLRIHLAPKRERRKIEELTKKKSEKAKNTDKAPTKIKLANKSYNTRKRLFKNEKKKRETYIRKSRNDKINELKWKYKATKCQMRVSKYEEILRKEASSLFDCLNAIFIYLVTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXK1</accession>
    <name>A0A367IXK1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003042">
        <property type="protein sequence ID" value="RCH82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXK1"/>
    <dbReference type="OrthoDB" id="2244979at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="28324" checksum="F44798D9CB95A383" modified="2018-11-07" version="1">MKAVGLDVQAIQDFQTKFMISNLTCPNVDKEVQQLMKKADKLSSLREKYNLHITTSLTFDGDIRKKLEILAAVYKNFVFKKNDVNSWKTMSEWSIIIKLWVNIFEILFEEEDYIRATKEDAAKVLVEAKTILNSLSQYHNLDLQETKNIKVVVGQFCGLKGEFKQIRLVAPGAYMVDKWGGTIKYPINERMVDTFVDKLEQLFVFKDDILKKAENLKGRLLEDDSLFGSQSTTEDQSFLKKKRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYG6</accession>
    <name>A0A367IYG6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ERAD-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002915">
        <property type="protein sequence ID" value="RCH82735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYG6"/>
    <dbReference type="STRING" id="86630.A0A367IYG6"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48373" checksum="B9DD21DC231D122D" modified="2018-11-07" version="1">MTLEQDQQLLENVPDELKLIQCIDVIQTTNDLNTCLQALNYLRGKATKHQDTEAKTKLSLLYTEDHKYITKDSAEVIIWSRSVFDKQLSQALHQSSIAFTTSRHTSGVQVIHEGTENDSNLCYLAGLLYTKGIGFEQNLERGITLLKYAATEGKLGEAACELGRIYGDRYRYSYHQLADSVYWFERGFECGSNQAIVDLAYSFFEGSQDVPKDDARAFRYAKDGALSNDKYCQYIVGHMYLKGRGVKEDAAEAMKWLDASAKQGFTVALEEQVAVYMHGAGNVPKDYKKAYQCCTQSIAANIPYCQVCLGDMYRNGWGVEQDFHKAFEYYQNAASTQQSDIPYSHAQHMIGEMFLHGEGVPKDLAVAKEWFQIASTHGYEPSQIKLQQISILEQNLLQQQREVLANGEGTTNQEKRSSRWSLGFFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZU5</accession>
    <name>A0A367IZU5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p24 complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EMP24_2</name>
        <name evidence="11" type="ORF">CU097_001659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002737">
        <property type="protein sequence ID" value="RCH83215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZU5"/>
    <dbReference type="STRING" id="86630.A0A367IZU5"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016892808" evidence="9">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH83215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22572" checksum="83E5EF2C7CF36345" modified="2018-11-07" version="1">MIVTVLASVLLLVQHIIALSINIKAGEVDCYYEYLEVGEKLIVSYQVGDGGNYDIDFWIKDPHDAFIISKVKQTSDAHSLTANIAGKYTFCFGNEFSTVSDKKVGFNVHENIQKIHESVKENTDPLEKEISELAESVFNIKAQQEYIVVRERQHRDTAESTNARVKWWSIAQLGLLVSVCFWQVYYLKRFFEVKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZZ8</accession>
    <name>A0A367IZZ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">URA3</name>
        <name evidence="12" type="ORF">CU097_007358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="PJQL01002718">
        <property type="protein sequence ID" value="RCH83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZZ8"/>
    <dbReference type="STRING" id="86630.A0A367IZZ8"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="29401" checksum="0EC6BBBBBD1E9B27" modified="2018-11-07" version="1">MNTFKSYGERAKQHSNACARTLLELMERKQTNLSVAVDVTTKKELLSIADAVGPYVCVLKTHIDIVEDFDTDLIQQLQELAKKHDFLFFEDRKFADIGNTVKHQYANGIYKIASWSHITNAHTVPGEGIIKGLAEVGLPLGRGLLLLAEMSSKGALTKGSYTTESVEMARRNKDFVFGFIAQHKMNEFDDEDFIVMSPGVGLDVKGDGLGQQYRTPREVIVESGGDVIIVGRGIYGQPDKVAEQAQRYRQAGWEAYLERLASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0Q1</accession>
    <name>A0A367J0Q1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRAPPC2</name>
        <name evidence="1" type="ORF">CU097_007940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002632">
        <property type="protein sequence ID" value="RCH83523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0Q1"/>
    <dbReference type="STRING" id="86630.A0A367J0Q1"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="65" mass="7544" checksum="3545BD122EA60B7B" modified="2018-11-07" version="1">MSNYYFVIVGATDNPIYESEIIPSSRSSAFIDPSRQKEDHKHLNQFIIHAALDVVEEYQWNVQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1Y5</accession>
    <name>A0A367J1Y5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002511">
        <property type="protein sequence ID" value="RCH83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1Y5"/>
    <dbReference type="OrthoDB" id="5561232at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016784754" evidence="3">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="32373" checksum="46EDFA4CD5C0BD49" modified="2018-11-07" version="1">MKFFTKAIFFLLAYILLSTTSILASPLRDVSTTSVDLTENPLDMNGDETLYVTVTRVDDLLDDDGSLLAERVMAVRVTFDVFENRLMCNGQPVEIGVSNIQVEAQMVSNPEKLTITSEEDAAILADSFDTGLVTVEITATLLDELKTDDGMVFRRLSVKELITEVNGAKVVQTEAAQQILDVFDNGALVKWTVDPLTGFMLPADDNSNASASSESALDSVSTWWHSQSSLNQEAICTGAAASGFLLLTLAFVLIHRSLKKKREYELVQEEEQPPAYDEQEETTVEEKKPFLASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2T5</accession>
    <name>A0A367J2T5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002414">
        <property type="protein sequence ID" value="RCH84264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2T5"/>
    <dbReference type="STRING" id="86630.A0A367J2T5"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="168"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="401" mass="44735" checksum="804A6A42334C9958" modified="2018-11-07" version="1">MSALTKACTVKGCCIEEIMLTTSVAAAATAFPLITVAQEVCRTAYWLPSSLVRIASDIWSHVQSKPRIPTWDIQTTIIIGFMQAFRSNSTSCSIAYWRLCTDSARIFGLIKAASIEPISVPIRSRGLYGILKKMDEEEKGDRTLYAEWVSAILPNISNYYGTENEKVVLYFHGGGYCMMSAQTHRILTTKISQATGRRVLAVNYRLAPETKFPGALYDAVQTFLWLISKEGGFKAENISVMGDSAGGGLCLSSMLYLRDHGLPLPESAVLLSPFVDLTYSYSSWDDCVMYDYLAPRPNHELTVNPLVLYLESPDFATHPYVSPIYADHFDHLPPILIQSGGCESLRDEIVALENKISKSKATKVRHEVYKDMMHVFQAFPFAKSAEAIENIGQWTRINFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J351</accession>
    <name>A0A367J351_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002385">
        <property type="protein sequence ID" value="RCH84367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J351"/>
    <dbReference type="OrthoDB" id="2258835at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="528" mass="61422" checksum="20F0E1D86DB2CB4A" modified="2018-11-07" version="1">MHNNNKNNILEENSWQIDNRNDPIFGQDSIEITAEDLYNQSDLTERIQDAEKRFSTSSITTSYFSSERFEYPAVYRVLFMGAAEQEVKKRLLEKLGQGFIHVLLDKQRVWGDQPIAPFREIKHNLVPLNNYYLDQRILSASYEEYGVSIIEADFTWTSTAAECSDDPAQLLLHYAWKQCPNPYELPSAHLGNDLPSEFQGTMCPDKTPNGIDLCVYVYDDENDDRTRRDMQLLYKIRKLGIYVLPLTLSRSEEIKSYFAKVLTQYQVPCLDLSTIQIGRQPSFLQYKKAATVDRLSRIQEMECREQLNRRPAVASYQILAVDQFCAIENTSILELLKRTRDREVERDENKRQDYRSLLPSATNSVESEEEQKKPVDTTQSDRYPMISILIIAILGILCAIYFASFNKAPEIWTARFEMMNRSDQIILVTRDPMGQLSWSRTDPMIWLNEQERIPIEKMSTGYYQLIIDNVNNSHILTFHVNTTDEHIIYFGSRTTFYNIAPTPTKSTRTTKSTERKVQSEIIIQILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3Y5</accession>
    <name>A0A367J3Y5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHS7_1</name>
        <name evidence="13" type="ORF">CU097_000169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002311">
        <property type="protein sequence ID" value="RCH84633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3Y5"/>
    <dbReference type="STRING" id="86630.A0A367J3Y5"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH84633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="22480" checksum="463716069B98FB5D" modified="2018-11-07" version="1" fragment="single">MVGIIYKFESFSFNGICQTVALSLCPLIGQPNGIEPVCYSRNIDLAGNIVFQPATLVTDIVAIIMAAIMIYHIRSKYTAVGRKEIVMFFYLYMITVFLEMLLVTGVIPTASPVYPWFTAVHIGLMCATFWCLLLNGFVGFQFAEDGTPLSLWSIRISSLVIFLITGFIAIATFQNISPFSNKAPGALWAFYFIFNGIAFIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4R5</accession>
    <name>A0A367J4R5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002229">
        <property type="protein sequence ID" value="RCH84928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4R5"/>
    <dbReference type="OrthoDB" id="10417743at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="88" mass="9964" checksum="ACD22EB645477E04" modified="2018-11-07" version="1" fragment="single">MDSITSYCNSRQLKFIHRILVRPSLVNCILTGVSLKIISATTTPISSKQSVLIPSSSEERQSKEKRLKDLKEEIMTLNAQLLKKKEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J515</accession>
    <name>A0A367J515_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002201">
        <property type="protein sequence ID" value="RCH85032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J515"/>
    <dbReference type="STRING" id="86630.A0A367J515"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="30"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="540" mass="60931" checksum="E2FD9321F6A30DAB" modified="2018-11-07" version="1">MASNSLLKWMGISGKAVADNDILDEGERYFGLENFGNTCYSNSVVQALYFCKPFRHCVLNYPQPAFPEISTPQTPLANGNGHYSFPSSTSITSTTAVPSNGSISTKLTSRNSINGMSNSTSSSNNSSNTNGNNANTGSTTTVEKDQNSINLTPGMEDTLFSSLKDLFWKISTHKKKTGVIAPVNFINKVKKENELFRSSMHQDAHEFLNYVLNTIAEDVQKYQQKNQQDESDSKKGSSIHSETDESSSSSKTTWVHQLFEGIFSNETKCLSCETVTSRDECFMDLSIDVEMNSSITSCLRQFSASETLCHKNKYFCDVCASLQEAERRMKIKKLPNILALHLKRFKYQEQLQKYIKLTYRVVFPFELRLFNTSDDTEDADRMYELWAIVVHIGSGPHHGHYVAIVKSNGQWMLFDDDVVTPIQEEDIQKYFSDLPGSGSGYVLFYQAIDLNMENISTPPLRNPMEYTAYSNGGPMPSGVSPSDPHPMSPLQLNFSHYQIDSPKREEFDDVPHTPHPLPPIEEKKSRWGLGRKMREKREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J670</accession>
    <name>A0A367J670_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002102">
        <property type="protein sequence ID" value="RCH85423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J670"/>
    <dbReference type="OrthoDB" id="2286658at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="29422" checksum="21B0AD5C6F2419E9" modified="2018-11-07" version="1">MSNSIQVYLHPPSPKECKLPSIDSIYDLNEPIKNDQLPIVCLTTDDQTKKLNTLEPQPHLTILTSPSLSSHSSALSPISPLLSPIEHNNLLAPPLPTSSSSTISASSFRRCRSASSNTSSPTCSPSYSFRSLKRGRPPNTSRPESQTTDNANWTFIKPTVWDVKNKNFELRNQKHQSIRPSFTDNNAISTFTSTNMDMTLSIPKKKRGRKPKKQLAGNSCFVWKDLTAPRGANKKRLLRLEKLAESRTILPATVPIPRLPRQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6D3</accession>
    <name>A0A367J6D3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002081">
        <property type="protein sequence ID" value="RCH85507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6D3"/>
    <dbReference type="OrthoDB" id="2287198at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="9103" checksum="2DF1551D6DB5C3D5" modified="2018-11-07" version="1">MSTYFFYEDGQGKVFDERGNDAMEWVEDVDPFHLETLTTFQKYKQAQPSEQERMRDELDETMNEVSLRCYISGIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J764</accession>
    <name>A0A367J764_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002009">
        <property type="protein sequence ID" value="RCH85812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J764"/>
    <dbReference type="STRING" id="86630.A0A367J764"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH85812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23920" checksum="452EDB56292A3840" modified="2018-11-07" version="1">MTRGLMIVVEGCDRSGKSTQCELLVHNLKSRNIDSELIKFPDRTTQTGKMIDSYLRQKSDLDDHAIHLLFSANRWEAMKAISEKLLAGKTLVIDRYAYSGVAFSVAKGLDFDWCKHPDVGLLSPDLVLFLDLSINEAEKRGGFGEERYEKRDLQIKVRTEFRKLKDDSWKFIDASSSMEKVEQDVMKIVLDEMSKPRKELQYNLWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7I3</accession>
    <name>A0A367J7I3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_007089</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01002014">
        <property type="protein sequence ID" value="RCH85789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7I3"/>
    <dbReference type="STRING" id="86630.A0A367J7I3"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH85789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="472" mass="54714" checksum="0644055E32383617" modified="2018-11-07" version="1">MSKEFKPTTWAAIHNATLPAEGAGNQTFDNRILAGAVLGVPAFITYSLGLGAWSFLFLTVLLFLPILACTLYLFSRFAPRYRNHIPLPGKPIESYLTFHDAELRAKYHGRNKIPMETFFEAYFVGKVDFNGDPLEIMELRHDWAAFQFTYGQFKFFLTQWLPETFWHSREQDENQVRDHYDRGNDFYEAFLGPLMVYTSGIISDPTKRETLEELQENKMELICEKLHMKEGDKHLDIGCGWGTLVAYAAKHYNTQSTGVTLARNQVAFGDKRIEEWGVKGKANLLCMDYRDIPKGQKYDKISAVEMAEHVGIRRFQTFLQEIRELLEDDGLFYMQVAGLRATWQYEDFIWGLFMARYIFPGADASTPLYWYLRQLETAGFEIHNVDTVGVHYSATLERWYENWMKNKGAMTEKYGSKLVRIWEIFLSWSVITSRQGSATCFQIVANKNRNSFDRAALICNRTNPRAWKSKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J866</accession>
    <name>A0A367J866_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001941">
        <property type="protein sequence ID" value="RCH86095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J866"/>
    <dbReference type="OrthoDB" id="10426403at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016842524" evidence="2">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="10130" checksum="91AB6770493DBEF9" modified="2018-11-07" version="1">MKLSNFGFLLGLYTTSSQVLAQTSDNTQTDMLNYHSQMNHLARRNFYNWSPGWNGWNGWNGWSGWGGWRGWGAPPTPPTPPTPPSPVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8W1</accession>
    <name>A0A367J8W1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_008143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001923">
        <property type="protein sequence ID" value="RCH86181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8W1"/>
    <dbReference type="STRING" id="86630.A0A367J8W1"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016604580" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="28"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="307"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="567" mass="58816" checksum="A893C8589AAF75D4" modified="2018-11-07" version="1">MRFGYYCITALGFLYLVSCQSGGNGSSSDNGSSSTNATTTNSTIYEVLNSTESSPVQWISQFLQSSPNYESLINLLNQSETNITVFIPSDQVYQAISSFMNSTNNTTNGGGTTNGGTNNGNSSNGGTSTNGSENNGASFNMSQYFTSPYIMNFNMTDVIYYHIVNESILIQDLFSNDTMGNATVVNSLVSNDTINRLGYGVQLLLQKIQANQTNSTETSGNQTNGTETSGNQTNSTETSGDQSSTLVTDGSSNNNTGFNYTIGNGFGYATINTTQIVQTSNGIIYIIDKVLVPPVDFNLTLEALPNITQFSNLTTEQFNITQFEQLFTTLNATNSSAFETLANMTNVTYFVPVDNAFAMTGESQVDNQTLPNLLAAHIVQGVYYTTNITNATEDITAQSLAGQNITLSKNDTSFFVNNATIVVPDILLDSGVVHLIDTVLNYTSGAGNNTTGSSNGTAVPPPPPGGSGTLSSIATSNTMSGATSNPTSTASGATGSGTGNASPTPTTSGATGGGTGNASPTPTTSGATGGGTGNAFPTPTTGSSSDASMNAPAMYLAAVFAIVAYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAI7</accession>
    <name>A0A367JAI7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_004086</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the NDK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001782">
        <property type="protein sequence ID" value="RCH86849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JAI7"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04416">
        <property type="entry name" value="NDPk_TX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000010">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="15">
        <location>
            <begin position="646"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="828"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1048"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1090"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1113"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1164"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1239"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1265"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1284"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1302"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1318"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1335"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1348"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1424"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1467"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1483"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1511"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1530"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1583"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1652"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1733"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="11">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1759" mass="194384" checksum="368B87FD282BE233" modified="2018-11-07" version="1">MAILSQGVGYGVVLGFGALFALIMTGITYLCKRYLKEVQTSEMYMTAQRTVKTGLVASAIVSSWTWAATLLTSTEVAYKYGVSGPIWYASGAVVQVLLFAVLAIELKRRAPNAHTFLEVVLARYGKGAHAVYLAFSLLTNIIVTAMLLLGGSAVVNYLTGMHTIAACFLLPLGVIVYTLFGGIKATFMSDYAHTVVIFIIIISFVFTVYASSPKIGSISTMYDLLTAASAASPIADNQGGSLVTMSSLQALLFGIINIVGNFGTVFVDNAYWQRAIAAHPQYAVKAYLIGGLSWFAIPFTLATTMGLAGRALQIDLTPFAVSQGLVLPDVAVALLGQAGGFACLVLVFMAVTSASSAELIAVSSVMTYDVYRTYIRPDAEGKQVVHFSHICVIAFGILMGVLAVLLNLTGINLGYLYTLMGVLISSAVVPLTLTLLWSKQNKTAAIVSPLFGFCAAVSTWLAVTYSMYGTITVETTAQNYPMMSGNIVALVSPIFVILPLSLIWPDNFDFDATRKIEKIDDSNDIGHEASEITQDELISMAKSSRFAKISSVVLSLALFILWPLPMFFSRYIFSKSFFTGWVVVSIIWMFCSFFAVGIYPIYEARHTLVNVTRELWRDLTGQRVPNLPQATHLSEENIVVYTNEKKQKTLAIIKPDAYHVKDKIIERIRQEGFTIAQEREITLTEETARLFYKEHEAKPFYEDVVKWISSSPIYAMVLEKEDAVQSWRLLIGPTDSNKAKETEQNSIRALFGTDALHNAVHGSDCHTSAEREIDLLFGQFGRDNGPSKEDLAIQDNTDLSVHTADHVEHTHQSEEKSDDAILTTDKRDATQEASMNQTEQEEAKEIEQPKDASEQANVQPEQKSSHDEKQQGTEEQANVTTETAANEKTGLVTPVLAQSEEQQATEHDTFETVEITNDVQHEVHEQIVTEVSVIEEQESSTVLSKEQINKPNQISEMIVEKGDAQEEQKQEKEQETTIETVSLLEVAQKHEMSTVTEQVVHTEVVTKDIKQEAITDIKTTENVDDKARTAENIKDSAESKVTETVNGHNDDKVDDTAKHEDKVTEKSNDESKVPEIAKHDVSCEAFVATKADDENKVADKNEDGASSAEVEQGDVKTEETKQEQIDTIVKEEPVEARENKVEENVKRETSVNKEPVSTHEDQHQTNARTEQTSIKDVTETLTPENNISPVVEISASTSTESADVNKVETGDADTVQINSQGTAIADGIESETEVTTNDEPYKPDEAEQEEHSLLDDEEHLIETVVHTDELKDMMEEAEVNNDVTTKENSEKENEGKGDTKESAPSVTPENQDGLTASDHVEESSSSHTEEHQTISRDSSSTANSSNTDNHKEAKDKSGVTKTKKTVVKESKTVTKKPLSKKAESTVSRLSNVKKPVANEEKKTHTTTATKPARVPRVATLTKKTTTDEKKSAEEKPKKVKSTTKSLVSRLTAPTEASARRKTTSAVVHEKKSTDSVEPKKKSTSPTSTTVKTIKKTTTITNNTNTANTTANHHEPKGTLRTATEKRAARTSPPSSTTTIKKVTSSKLNNDTHKDTTSRVSGTLTRKEMQKKPVKKVVAKSAHGKKEETSKKDVKETKKEATPKAHVEEQKESDDDHKQEVDVEQEEHQKKETEQEEKEHEIIIVETHEEEIIEHNEVHEEEPVKHNEPHEETKAQDELHAEEIKGHDDPQNEPSKDSHVDLAPEQPKQEERRRSRSPEIASIRNKFEALQAASVVTSQSKELRSKSPNRVSDMINRFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAU7</accession>
    <name>A0A367JAU7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HUT1_2</name>
        <name evidence="11" type="ORF">CU097_009506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001738">
        <property type="protein sequence ID" value="RCH87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAU7"/>
    <dbReference type="STRING" id="86630.A0A367JAU7"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="367" mass="41680" checksum="C691514C3BDED0FE" modified="2018-11-07" version="1">MLRFAFCVIGIYTCFLTWGVVQERVSTTPYGDTEPPKKFKYFIVLNLVQSLIAAIVAFIYLKVCGKSLNLKDTPYSLYLKYAQVAFFNCIGSPFGYEALKHIDYPTMILGKSCKLVPVLFMNVLVYRRKFDWHKYLCVTLVTMGVSMFMLYHETSSSKKAAATSSLWGLFLLSMNLAIDGLTNATQDQIFTKYKHLVSGQHMMFYMNIISSVFSAAYLIFHPFNNELQQALLFFHQHPAVIRDVLLFGFCGALGQCFIFYTLQHYGSLRLVTVTVTRKLFTMLLSVFWFNHTLTFGQWAGVALVFTGNKNKTKSKSEINPELCTAIGIEAYIGKQQKLQVKKTMNASVKELDIKKALNGEKPAHKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB17</accession>
    <name>A0A367JB17_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001732">
        <property type="protein sequence ID" value="RCH87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB17"/>
    <dbReference type="STRING" id="86630.A0A367JB17"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="224"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="981" mass="111265" checksum="1E81E75FD8D6F93B" modified="2018-11-07" version="1" fragment="single">MDKFNRPPPDIDNIDNEQPYVSLTQFDTELQQQAQLVMEQDIDVWQDFENYLPLAYQQSNSRNISQPTNSQLLDFMTNNDLPFNSVLSTQNNSSLKLYPQQNNMWPSNDISFISPHSDPIPSPFSSPSSIPEPLSSPGQLTTPFEPSSTATTVNIALNNSASSTPDQSPKAETFSLNFISVPDQQQQQHQQLNNLACKPTIKIAQSQDKATAQTSNPSSAAPQQKKRAHNVIERRYRNNINERITELKNAVPALLHAKVKDGNNSAKTGAKRGRKSSHDDDDDDDDNEDDEEYLDGVAIATKLNKATILRKATEYILHLRRSGDVLRHENDILQSLIGQLPGGQEILSRYLLQKMQRDQEMQQQISYERQLQKQMKQRRKYPVGRKRSRLSTLDDGTASQVKHEPVPLVPATPSVTNRVFMAAFMAISFFSSSPLFTGPTTKEQFESHHHISRTVDEYPSNNGNRESSLLGLFFSTQDTWSTFRTTIFVICLFQLLFPLFKSWILGSLRIKSVNKRSRVKSSSSGNIASHVTSLTPGDQKCMQIYNILAKSLENDSNNRKRAVFPQKRGSTVSLCLSLCKEIARFISRHWLGYEILYDDHDLAPQEQWIQTCKWIKLNEVECLGGNPQITRISMLFSCFRVLNLIEMMEDDENEYVEQSRSRVYATAALQMALIIPHHGISQSLSKYFWRMAMYESGLEDDPLMSALTFDCHEDDGEDRIEVMLKSRAWNETLEVMSHQIQHFKQDRVYGLSLSMNAPVLVPVGILSTLHLLDNLQTQFGRLIISVTAAPLLSDELRDEEEEDSDFNETAFAQILDMTTPQEDHERVDDYHRLAHWLAAVGAIVEALWKSDTKTANKLINTILEKIPLSLVSREMMGSDVDMVGHKERLNQLDGLTKKSIIHTLVGAALLKKGKPEDLFRGVEELWNAERIKMTMKKLLARIDNNHEHRNQILKDSEDIIDLESSVLGLAEFVTAVTGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBL9</accession>
    <name>A0A367JBL9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NineTeen Complex (NTC) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ISY1</name>
        <name evidence="4" type="ORF">CU097_009848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001723">
        <property type="protein sequence ID" value="RCH87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBL9"/>
    <dbReference type="STRING" id="86630.A0A367JBL9"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="23186" checksum="562C7CFFDE331CB9" modified="2018-11-07" version="1">MARNEEKAQSMLYRFREAQAAQLGLAKTRQRRPGFAGSVTSITEAEMWRRDLLSEISRKIAKIQDVSLSDYQVRDLNDEINKLMGQKYHWEKRIVELGGPDYTRSGPRMFSYEGREAPGIRGYRYFGRARDLPGVRELFEQEVAEPVNRSITEINRDIDANYYGYHDEENQALLEYEKALEKELAQKLLSTPLESLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBW3</accession>
    <name>A0A367JBW3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001672">
        <property type="protein sequence ID" value="RCH87375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBW3"/>
    <dbReference type="OrthoDB" id="2214365at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="153" mass="18069" checksum="E6092CCBCC3C983F" modified="2018-11-07" version="1">MNTFFYKDGFENLYNEQGEKVYDPMEGILSDVINPNIILEYVTSREKYLSGKRSEKMIEEVSIKNQPRAEKPKQASSYNNYSDFTTETFIDRMFEQPVKRDVVSKVARDLNINYHTAVGWWHLHNETEDIAYKKSEQNNGPKKLIYDCTQRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC08</accession>
    <name>A0A367JC08_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001651">
        <property type="protein sequence ID" value="RCH87467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC08"/>
    <dbReference type="OrthoDB" id="2264705at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="51" mass="6010" checksum="C38FCB850DAF8397" modified="2018-11-07" version="1" fragment="single">MKDIDVCYIDDPTDPILVSLRKININPFRYRRYLSTLEETTHITDALQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCI0</accession>
    <name>A0A367JCI0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclin-D1-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CCNDBP1</name>
        <name evidence="10" type="ORF">CU097_006549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001610">
        <property type="protein sequence ID" value="RCH87672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCI0"/>
    <dbReference type="STRING" id="86630.A0A367JCI0"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="174"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="33382" checksum="8101B28C69CC6119" modified="2018-11-07" version="1">MCNLYLEEIREERNVTDDKFNTVTFKDTMVNLGKVLSHDATKFTLSCKPPRKPNDAIRMIQEISNTVYRIVGFYHTIPVSAGKIYKTQYRLAVNELIQGVMSLCSNFLPEEHKVSFMVPTAAIWDSCKELVKLPKNNQEAVIQAWHELEGTLKDAKTEVHEIVAGEDRSEGFDDNEGSDDETELGQEELEVAKSCAKLVDMAVFVLQKIERRCLRNSESVTWLDDVYTAASQLVDETDLLVSQIYDEDAAYMKEQVKRYIEHSTSLVKIAKQEAKGEHADWFAMCENKYESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCS3</accession>
    <name>A0A367JCS3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001613">
        <property type="protein sequence ID" value="RCH87659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCS3"/>
    <dbReference type="STRING" id="86630.A0A367JCS3"/>
    <dbReference type="OrthoDB" id="10368008at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="29119" checksum="8E5A4D3172A8A53D" modified="2018-11-07" version="1">MATIHKDLVFFEGRIADIQKLISGKRGSTVNTHTVPAREAESVVPMTSISSLRLLNDFTHNSKYFESNKAHPVDASTDKAFKTIGAFLDKFELTLAYHRVNIGKEWYNYLQTSVQDGQDSRYIKWLKQRDQEANFKSSKWLEVREMLIEKFYKSFSYLQYKEKMMRCKQRKGEYMHLYIERFLDLVTKPSSPIILPWYQSFSIHCWIPYANRNQETRRHEKGRRNVSCWALCLRRRDSRAITPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDB2</accession>
    <name>A0A367JDB2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEAT repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HEATR2_2</name>
        <name evidence="2" type="ORF">CU097_009910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001569">
        <property type="protein sequence ID" value="RCH87906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDB2"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="1">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="497" mass="56280" checksum="187FC70CAB5F1F9D" modified="2018-11-07" version="1">MATEIEEINNTVSPYFSVLEDTSTKDRPAKRRAIDGIKKSYSQVKSSSVANGLIENTTHSLLICVESEIESVRENSVHILKRLIAINDKESIQETTLVTILKAADKRLDQSIEQTEEIRAVWMELVIMLLELQSSNIKAEHFMDILQTAVKDPFSEVQKLASTLLCLFTIKYPKMVDYACDRMIEYVIPLLIHKHTAIRSSGIKAMEAVLLTCAKGFHLLFEYNEDLDKQPIIPSLIYDPSALVRQQLFTTLGNLLCEWSPRDRYEHGEKILPVILSGAFDELPAVESTCQSALTRVADICVHDLHDAEILKEIPIDASVRKTIGLKHLVHICYDSSLNYLLDKSTDFVISRQITNLSALKLFLEYASADDLVRTFKKLMNCLVLVFSSNHAAESDVFEILSIISNQLHSVDIYLDILLPKLDPRYLNDETSNFPAEVVITTVITFLEYLITVTEVSTQSTDRIKKALQRPHFENYKNRLSSKTKQSITALNENVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF12</accession>
    <name>A0A367JF12_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001462">
        <property type="protein sequence ID" value="RCH88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF12"/>
    <dbReference type="OrthoDB" id="2401156at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="384" mass="43653" checksum="1488543B40FFC30F" modified="2018-11-07" version="1">MIFQDNTRNNTKPAPYTPLPKQEAQPKRSNTLPTSAATTKRSNTLRKTPTLKSYEKHMPKPTYSQQESIYRFKSNDRKDDNKQNNREQERPWSVIGSSDTKDTYTISWKDEGTGDDLLTPLVTFQTIFESVDKNEGLSDILEQKAKELKDKKLKVQEPEPTEQLPPRRPDCLTLSYRQGPKHNPLTLYHTMKMNKENERLNAYGIAFNHCIQSNSGLKDWIKKPKAPPPVREGSKLIQTAHQKPKRSLFSTLRKGHKMSNHSEEQLMFWASTDQLSQKKKSTETLNQPTDILLAAQALLPNQQGSITIEPNQKAPYDHIDVPGKPRVMDTKDVNNSISSTESNTSNKIVNKSGRLFSSLSRKASLKSYSSDTSPSIKSLEKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFS2</accession>
    <name>A0A367JFS2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001400">
        <property type="protein sequence ID" value="RCH88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFS2"/>
    <dbReference type="OrthoDB" id="2277358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="12921" checksum="425AA45516FC5BFC" modified="2018-11-07" version="1">MIKAIADRFYLGTIKTFSKLKVSFIHASDMLHKTIYVWSLIYTEEGSAYEMWLEGAQDVVLELEREHKSKLRECGFSAVQPENLSTIVNPSIMKLIEEEEKTGMRRLGSLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG97</accession>
    <name>A0A367JG97_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001365">
        <property type="protein sequence ID" value="RCH89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG97"/>
    <dbReference type="STRING" id="86630.A0A367JG97"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016628206" description="TM7S3/TM198-like domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="80"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="326" mass="36019" checksum="0E7F32A3F6BBBA69" modified="2018-11-07" version="1">MYLLYLLFLAQLISAAPTGDLPQNPPGTAYLPDKAIVLDDGYYLTVQGMLGGIIIIVSGLLLIFRSLWDRTLAGTHTQNLTGFITLGLVAWIMLANFEPQQSYGTNRLTIYFIVPLIIGLIATCFMFITVQLYLMLLGGLGGLAFGLWILGWKNDLSITSGYGRAILLTILVIVFMILSLYHHSMHKLGAALAGSYMLFMGLDIYFHTGFLYCFTTTLDANHSHKYQVYREVYIMQSCLIIAFLVSYICQGLGIRPGILHQHRVCMSTYTSNPEYNIKGSAQGFFVPTRFVPQVNWRFWAPRPPVAQAIPVAAPAPAPAPAPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHI7</accession>
    <name>A0A367JHI7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS7_1</name>
        <name evidence="5" type="ORF">CU097_007625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001290">
        <property type="protein sequence ID" value="RCH89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHI7"/>
    <dbReference type="STRING" id="86630.A0A367JHI7"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="192" mass="21310" checksum="E86CFBCB8C460214" modified="2018-11-07" version="1">MASNKIVKKAGAPAANEFELSVAQALVDLETSVPDLKALRALQISAAKEVELGGGKKAIVIFVPVPSLNAFHKIQARLTRELEKKFSDRHVVFVAQRRILPVPTRRSNDKQPRPRSRTLTAVHDAILDDLVYPTEIVGKRLRQKVDGSKTLKVFLDAKDATSLEYKLDTFSAVYKKLTGKNVVFEFPANAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHW6</accession>
    <name>A0A367JHW6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OST1_2</name>
        <name evidence="11" type="ORF">CU097_010197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001275">
        <property type="protein sequence ID" value="RCH89517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHW6"/>
    <dbReference type="STRING" id="86630.A0A367JHW6"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016480176" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="28"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="476" mass="53973" checksum="A1C9AAD82882AE41" modified="2018-11-07" version="1">MSVVRFMCRPLLPLLLLLIAFNHVCYALTIPKQFENTKIIRTFEVNSGIAREDTGIRAKNIGDGSASEYYFYLPNVLYKNVASVSAFLRKQKTELQVSLEGLDAEKEVYVYKIDLKEHSVQPNEDVLLGIKVAYTHVIKPMPAKLPQLARQHTMIAFNSYFLSPYFTKEIKTTLTTPTQNVVSHVGDLGKSSLNGNKVTYGPYENVEPLSFGVATCHFENLQPILTVPSLRRDIEVSHWGKNLAVEEHYSLRNDGASLETNFNRVQYQMTAHIHSQTNVLKELSFKLPPSAQDAYFRDEVGNVSTSHFRVENKNAVLELAPRYPIFGGWNYTWYHGYNADLGSFVRKSKTSGKYILNVKFVENVNDMAIDKAVVRVILPEGASNIKVHSPFSIDAQTIVPHFTYFDSTGRVMVVLEKDRVVREHEQFIQIEYDYSISELLRKPIVASTALLLLFVTSILFGKASFNIGKEQKVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI81</accession>
    <name>A0A367JI81_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_004438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001252">
        <property type="protein sequence ID" value="RCH89637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI81"/>
    <dbReference type="STRING" id="86630.A0A367JI81"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="609" mass="70330" checksum="D264E42599EABF3D" modified="2018-11-07" version="1">MSIYNMSKYDKSRSRTASPRPRIVGGPMRPMPNAQQRMMAQQQQQQQPQQQFQQQFQQQFIPPQYEEFQLYSSSKTGQHHLMDFKTNKKVDFKSFAPPVKLHRKEPDRIPYRQYIQQKNNEQQQQQQQQQGQQQQQQPSHGPKTGADTSLIAPMGGATRNKQMLFKKRTKQIYLAKEDTRELKEQEQRPWILEDIEGQNNFTGTLEGGQRSDYVFFVLTNDGFKVVPVDRWYKFQPKRNVKTLTPEEVEEAFKKRNRQPDNQRWAMLSRREKENPESPIPRQKFKVVDNGERKGAGSDDDVPTKRDSDIDDLDFDEDFQDDEEDGAEHEAEDEEVKDSKERFKKEIKGFTINGGDEDEIDTFESTSKLSSEGKQLRKLVRDLEKNRAYESDEDEDPYASSADEVVSDDEEKKSDEEGKEKSTPALPKKKPTMANSPSKLFMPKKPVTKVKKESVSRPVGRPESPSLFMNKKKEGSPYPTSPTHKPTSPPHHPNGNHSPTAPPHSAPAPVDQNKKRKPEDAPSGHSPDHKHRKMPGPSDEDLITEQEVIETLRGRKMTTKEFLISFRKRIKKNPRNREVITALLKKVARHSASNDPNTHILELKPDLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIR9</accession>
    <name>A0A367JIR9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MNS1_1</name>
        <name evidence="15" type="ORF">CU097_006351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="PJQL01001215">
        <property type="protein sequence ID" value="RCH89862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIR9"/>
    <dbReference type="STRING" id="86630.A0A367JIR9"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH89862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="568" mass="65823" checksum="4B7703781B5F6754" modified="2018-11-07" version="1">MLPTHNRMKNGRRDFYVDDKYEKIHKQRWLYSRNVIFCISILIIFLYVNKYVLVENDNKVLDNSNQDTVQIKEEEEGSLTGLLFTQYPPVQSLRHSDEQTAQRQKKIVDAFLHAWKGYTQDAFGKDEYQPLTHTGHNWAPGGIGLMLIDSLDTIMLMNLTEEYNQVRNWIATELDFNKDQDVNVFETTIRVLGGLLSAYHLSNNDLLYLEKAQDLADRLLPAFDSSSGIPFNGVILSTGQPSTHGESSSTAEATTIQLEFKYLSYLTGDMKYWKAAEKVMDRMHELTKDNDHQALDGLVPIYIDPHHGNFVTKEIRLGSRGDSYYEYLLKQYLQTNKTEPQYRQRYDAAVEGIKKHLIQYSYPNHYMYIAELLDRTTPGNRHPKMDHLVCFMGGNFVLGATEGGSIQNANIQNSDDVRLGEEMTKTCYEMYNMTATGLASEIVYFNTNDRSEGPDMEIHVRDRHNLLRPETVESLFLLYRMTGDEKYREWGWSIFESFEKYTKLPEGGYSALKDVTLIPPVRDNRMDTFFLAETLKYLYLLFSPSDFIPLEYYVFNTEAHPLPIFTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJW6</accession>
    <name>A0A367JJW6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_001483</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="PJQL01001152">
        <property type="protein sequence ID" value="RCH90244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJW6"/>
    <dbReference type="STRING" id="86630.A0A367JJW6"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH90244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="287" mass="34242" checksum="61CE5BC23CD32912" modified="2018-11-07" version="1">MRNLSEAVKVTEAWETFIKQKYGHNHSNKETSDFRDYQLASKVQPTVENFYKENHEKQTLEHVLDKKKTYESLTHGEMGIWEALELMNTLVDESDPDTQMPQIMHALQSAEAARRDNQPRWMILTCLIHDLGKYLFFLGEPQWTVVGDTFPVGCKFSEKIVYSKYFEKNPDYSRQEYSTLHGIYSPHCGLDQVHMSYGHDEYLYHVTKDYLPPEASYVIRYHSFYPCHTEGQYSWLLNQYDVEMMKWVKIFNQYDLYSKAEDEPDVEALKPFYQELIREFFPEKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK17</accession>
    <name>A0A367JK17_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHS1_4</name>
        <name evidence="14" type="ORF">CU097_010825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="PJQL01001145">
        <property type="protein sequence ID" value="RCH90292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK17"/>
    <dbReference type="STRING" id="86630.A0A367JK17"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="94"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="840" mass="95069" checksum="D6467CA1CA2DFAEA" modified="2018-11-07" version="1">MSEETSTFGGWLSNWFNTSKEQESSTNLLQQQQQQGTNYARNQQTLSSLRSQKQQAEPSNKQTENNRHKLTRSDTEKSYLDAPKSQQAGNGRKITRRLPLTNNHLVVDCPIPDRLLGALNFSERDEFSQLRYTAATCEPDDFETEGYTLRQKIYNRETELFIVMTMYNEDEVLFTRTMHGVMKNIAHLCSLKRSPMWGPDGWKKVVVCIVADGRKVVNKRVLNVLASMGIYQAGIAKNVVDDKPVKAHIYEYTTQISIDPSMNIKGSDKGIVPVQVIFCLKEKNAKKINSHRWFFNAFGPILQPNVCILLDVGTRPGNSSIYQLWKVFNNNPLVGGACGEIRAMLGTACCQLLNPLVAAQNFEYKMSNILDKPLESVFGYISVLPGAFSAYRYAALKNDANGHGPLEKYFLGEDLLHKDQSGKQAGLFEANMYLAEDRILCFELVAKKNERWLLQYVNSAFGETDVPNQLPEFISQRRRWLNGSFFAGVYGLIHFSKIWNSGHGFNRTLLLLIEGIYNVISLIFSWFAVGNFYIAFYFITKSLADPSVDPFGNGWGERVFDFCRYVYASLLFIVFICSMGNRPQGSKHLFMACLVGFACIMVYMLFCASWLIYKGIQLAAERYQWTLDTTTNFQIAMNDPGLRNMLISLSSTYGIYFVSSCLHGQPFHMFTSFLPYLLLLPGYINILNIYAFCNTHDVSWGTKGDNTIAKDLGIVKVSDEKEKGVKTAEVELPADQYDINCQYDAALFALDDRPSKMEENKSTLTKDDYQRAFRTHLVLAWIACNAILVIFITAPSYESIFVQSAGTTYMSVLLWVNCGLGIFRFIGSCIFLLLSIFTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK56</accession>
    <name>A0A367JK56_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ATG9</name>
        <name evidence="20" type="ORF">CU097_007284</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 18">Preautophagosomal structure membrane</location>
            <topology evidence="3 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001141">
        <property type="protein sequence ID" value="RCH90313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK56"/>
    <dbReference type="STRING" id="86630.A0A367JK56"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0072">Autophagy</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 18" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="592"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH90313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="664" mass="78445" checksum="C51FBFBBE33B6EC9" modified="2018-11-07" version="1">MSSSRLFRNDSEEELMLNHLSEEEDEDLEAPASLILERPKNDRPTLLSTRDHVSIEDRTMWRWANVENMDYFFQRVYDYYQGKGIYCILLARLLNLLTLSFMIVFSTFLVGCVNYSEIPSSHSLDQVIVPQCLSKLSTTKFLYLIMFVLWWLWQAIRFVTDIPALKEMYNFYTILLNIPDAILDRIIDIRETNPNTSEQSPIRLTEHDVASRIMRKENYLIALFNKDIFNLTIPLPYLRHRQLFTKDIQWNLSFCLLDFVFDQRGQIRKRFLKEKNKQILVAGLKRRFIFMGLLNCVLAPFIFIYLFLFFFFKYFEEYHKDPSRIGSRTYSPFAKWKFREFNELPHLFDKRINQSYEYANLYVNQFPKEKTILFARFASFIAGSFAGVLALFSLFDSEALLNFEITPNGTVLFYLGVTGTIFAVTRGMIPDEKQVFDPERTLKQVIEHTHYLPSKWKHKLHTDQVRADFCLLFDYKVGLFLQELTSVLFAPLVLCFSLPKSAEQIIDFFREFTVHVNGLGYVCSFAQFDFEKHGNPRYGVEGVLVEDEYYLSNEGKMEKSFLNFKANHPHWIPNDMAGSLYLSRLERFKNQKRQNDITKDEPSPIRLNKYGIPSNLGDSFEPSTPHFQYQQHHEEEEEEEEEEESTKKNVVGLLNQFYDLNNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKD2</accession>
    <name>A0A367JKD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_010263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001127">
        <property type="protein sequence ID" value="RCH90402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKD2"/>
    <dbReference type="STRING" id="86630.A0A367JKD2"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH90402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="288" mass="33272" checksum="462B8CFD58F1C21C" modified="2018-11-07" version="1">MSTYNCVSIPQSTFYDTLYSIPTGRSLSCSSSSTSESHWEDDESTKRSSKKGVSTFISKLFSIVNDAHNQHLIAWNNSGTSFFIYNATRFSQDILPIHFKHSNYSSFVRQLNMYGFHKINKSPRGQRGSNEYEVWEFSHKNFQRDNPSLLEDIKRKTMDSELLRRENGDVHASLATMQQYQADLLRQFKTLQENYSNLLQNMEEMKKTQDQQQATIRKLLDYATQTSSIKAHQNMSDMAVMPTYQTTSQSNQKSHGYSAINQDMWCLSNFNPHLSSSYPTTDFCGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL72</accession>
    <name>A0A367JL72_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001094">
        <property type="protein sequence ID" value="RCH90619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL72"/>
    <dbReference type="STRING" id="86630.A0A367JL72"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="525" mass="59229" checksum="A839EA2EE9487943" modified="2018-11-07" version="1">MLACPQEIFFHNDTSMQPQAKKSRQYNRKDQYNGLINNPNVIISANTFRDKEEQVWPPDVEDAFTEALESIPKLGRRKILVNGKPCGRNELISDFIYRKTGKIRTRKQVSSHIQVLKNTRKSDFHCKSHSMHYLTGINTSSVVMRLLTDSNEVSEESNNNNKSCAQPVSTHMHPSSSAPTSSVNPQLKTIKSIESFSSDDSSINSCSPSPTDFMLDMMQGDPAQRHVFSVLKDLYDPFQQPIFNDLMHLDPLMTGMDPFLGTFPTLNQSVVDTANLMLPNQQNTSMIESSSPLPSTNEFAFWPSYFCLYLEYTLPCDPYRRLTYNLAHMPQCHPSSISTISLEGLPKEKCPPLATLSPDTVALMAKVCSSTQVKIDLSLDISDFTFNNTSYFETSERKTMECTTTVYSFGNIVLESKESQQALWLTEGKYVYNFALVNQFLDAFIKGIRSLLSWEEVDMAINNLCIVQSFEDVEIKLCGTNQPPSLVIAYEFERGPATIEVSAISNKIVNEKFNQGLEFLGELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLB4</accession>
    <name>A0A367JLB4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001084">
        <property type="protein sequence ID" value="RCH90685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLB4"/>
    <dbReference type="STRING" id="86630.A0A367JLB4"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="17058" checksum="F67FFD1EAEC54822" modified="2018-11-07" version="1">MVSAFLSEGPQFRPEFKYGVEFKKTATSEEVKENQTVVKFAAAAFNHRDIWILTGNYAGIVLNSVLGSDGVGHIIKNGKIDQRVLVNPAIGWISDPRKPEKTPHIFGLLPAIGTLTEEPVVVDQEDVVPCPEHLSLAEAAALPLAARFPLGPTLSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM46</accession>
    <name>A0A367JM46_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putrescine aminopropyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SPE3</name>
        <name evidence="6" type="ORF">CU097_012377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001036">
        <property type="protein sequence ID" value="RCH90997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM46"/>
    <dbReference type="STRING" id="86630.A0A367JM46"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="33007" checksum="126D7F514BEE7445" modified="2018-11-07" version="1">MSAPISHPCIVDGWFMEKSTMWPGQAMSLKVEEILHHEKSQYQDVLVFQSSNYGNVLVLDNVIQATERDEFSYQEMITHLAMNSHPCPKKVLVIGGGDGGVLREVVKHECVEEATLVDIDEAVPRVSKKFLPNMAIGFDHPKVKVHIGDGFEFLKDKVNQYDVIITDSSDPDGPAESLFGPDFFQLLKNALTENGVFSTQGECMWLHLPLIKKVKDFCKNLYPQVEYAYTCIPTYPSGQIGHVICTKNPNANLKEPLRKFTPEQEDKLLRYYSADMHRAAFILPQFAKKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMR1</accession>
    <name>A0A367JMR1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="20">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CU097_003755</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="20"/>
    <dbReference type="EMBL" id="PJQL01001003">
        <property type="protein sequence ID" value="RCH91217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMR1"/>
    <dbReference type="STRING" id="86630.A0A367JMR1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="982"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1060"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1090"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1135"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="911"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="17">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="865"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="889"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="889"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCH91217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1232" mass="140874" checksum="DFEAD041A532E47F" modified="2018-11-07" version="1">MSSFSSSSPFNWESQEKSRTNLIKKVRSFETAYTSEDGRTMPEDYEEGIGLLKPNNNMPTSFVPDYSFSSNANLLNVTEATEMLEHTPQTTKETKETINKRPFRWKQWFTKNTVPEGTPRRIYVNKPEMNEQQHFMTNAVSTAKYNLFTFLPKFLYEEFSKSANIFFLFISGIQQIPNISPTSRYTTLVPLVIVLLITAVKEVIEDFGVHKSDSELNARKCKVYDGSRFIEKPWRQIKVGDICRVDNAQFFPADLILLSSSEPEGLCYIETSNLDGEVNLKIKQALPVTATMVSPAQLATFEGMIESEQPNNRLYNYDGTLTTKDEDGNTKRFPLDPNMLLLRGAQLRNTSWIYGIVIFTGHETKLMLNSSKKPTKASNVTRKTNRNILYLFAMLVTMSVLCSIGNYVTSTRDGANLDYVGVPITQLGKEVGYNILTFMILFNSFIPISLMVTMEIVKYIQSTMIDNDLDIYYDKTDTPAVARSSSLIEELGQIEYVFSDKTGTLTCNEMEFRQCSIAGLSYASHPDPDKRPTSDDDAHGQFSFEQLEEHLQTSQHKHIINEFLTSLMTCHTVIPETENGTIIYQASSPDESALVKGASEVFGYKFVARRPHSIHCIRKGTEEEYQILNVCEFNSTRKRMSVVLRGPDGKIKLYCKGADTVILERLAKGSNPFVSATLSHLEDYACEGLRTLCFAMREISNEEYTEWSVMYDKAATTLVNRADELDHVAEMIEKDMFLLGATAIEDKLQDGVPDTIHTLQEANIKVWVLTGDRQETAINIGYSCKLLTEDMELVVCNEEDQISTKKFLQERLGQLSAQMQQDPLALVIEGRSLTFALEKDVEKTFYDLATQCKAVICCRVSPLQKALVVKLVKKFSKSILLAIGDGANDVSMIQAAHVGVGISGVEGLQAARSADFAISQFRFLRKLLLVHGAWAYQRLSKMIFFYFYKNVAMYLTQFWYAIFNGFSGQTLYESWTMSCFNVFFTFLPPMAIGVFDQFTSARLLDKYPQMYTLGQRNEFFNQKRFWGWIFNAVYHSAMLYFLGMAAFADDSVFTNGHSGGQWWVGTTIFTATLATILWKAALITDIWTKYTFIAIPGSMVIWFIFLPLVSYVGPLLPVDIFMEYYGIIPELFGNINYWLFFIIVPLMCVLRDYLWKYVKRMYRPQSYHYIQEIQKYNLPDYRPRMDRFRRAVNKVRKIQRLKQSRGFAFAQNDNDQSRLIRMYDTTRQKPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMZ8</accession>
    <name>A0A367JMZ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_004992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000987">
        <property type="protein sequence ID" value="RCH91312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMZ8"/>
    <dbReference type="STRING" id="86630.A0A367JMZ8"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8713" checksum="25E9E39DFD3CCABA" modified="2018-11-07" version="1">MSIQQLGKILGIIGAIFLAHSAYSTYEHLAYVKAVDEEDASVPIEIAVECLVSSFIALLGVILSADSFKHIDMTDEIQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNG8</accession>
    <name>A0A367JNG8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SUB8_4</name>
        <name evidence="10" type="ORF">CU097_006820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000970">
        <property type="protein sequence ID" value="RCH91435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNG8"/>
    <dbReference type="STRING" id="86630.A0A367JNG8"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF13">
        <property type="entry name" value="SUBTILASE-TYPE PROTEINASE RRT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016611944" evidence="8">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="156"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="52582" checksum="254B414D4CB11B1B" modified="2018-11-07" version="1">MIAILFLLCLYFYNVVLASIHKNVAPVVSELKDTDQYIIIFKPEVPSIKIHNQLKNIQLHQTTKHKSHHTSKLHTVDNSYSSIGKFKWYSAQFYSEPFEEYLSTNQTVNDTVHYWVKDTQFSLQEFIQTNPPSWGLDRIDQREGLDNEYRFASSQGTGVTIYLMDTGIREDHNDIAGRVTIGKTIVGDPNDPSDKNGHGTFVAGVCCGTKYGVAKNAQIVSVKTLDDEGNGRLSDVLIGLEWIVQQHKSQPNAKSIVNLSLGALYSQPTNDAITAAMSLGIHFSIAAGNYGEDACKYSPGSTPGAITVGAFDQDDSVSYYSNFGKCVDIFAPGTNIKSIWPTSQDATHVLTGTSMAAPHVAGTMAIFLSQANFTPPELATYLKNVSTLRTEDFTINNTGTWYSENKTVVDNAIDVGYQVQNLMNQKTRVNLLYNHPQDGQQFWVYGRTLNSASILSFNFMIPLFTAIITFIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNU8</accession>
    <name>A0A367JNU8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000947">
        <property type="protein sequence ID" value="RCH91598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNU8"/>
    <dbReference type="STRING" id="86630.A0A367JNU8"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="155" mass="17663" checksum="DD1B3040E940A30B" modified="2018-11-07" version="1">MLISNQGNPNKIKRDSVLAYITVTVDTLLPCSNCKDQQRILPPLNEFVNSFIEKSKLPIPILLITLLYLTRLKTKLPSTAKGAYDTPYRLFLASVLTSSKYLSDLNSLTSIRVCEMIQRQYSVREINSMERSFLSLLSYDLRVTADQLQELNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPI3</accession>
    <name>A0A367JPI3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000919">
        <property type="protein sequence ID" value="RCH91795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPI3"/>
    <dbReference type="OrthoDB" id="2202855at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WWE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="68" mass="7744" checksum="93411601BB290B14" modified="2018-11-07" version="1">MAIQWVYANGSIWTIFDKNTQQQIEALWSKHTSGWIQSSSFRGPVFVDTTQMVLIADGYSCAIARRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ00</accession>
    <name>A0A367JQ00_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_001328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000887">
        <property type="protein sequence ID" value="RCH92022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ00"/>
    <dbReference type="STRING" id="86630.A0A367JQ00"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="778"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH92022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="920" mass="92322" checksum="C0651D918131C062" modified="2018-11-07" version="1">MFGKSTFGTSTGGFGQPQQTSNVFGQQPQQPQQPSAFGGFGATSTPNAFGAANTGSAFGQPAQQQQQQPAFGSTAPSTGFGAGTSAFGQPKPTGFGGFGSTSTPAFGSTQPATTGFGGFGSTPASNTSAFGSTSTSTGGFFGQRPATGGFGSTPTTTAFGQPQQQQQQTPAFGGFGSGGTAFNQPAAGANQGTAIADFTATQDRDITTGVNNFFQTITAMPQYKDYSLEELRLQDYVQGRKTASAFGAPAAGGAFGQTTSTMGGGAFGQPSTGGAFGQPAASTGFGQPAQSNMFGATANTGGMFGQQQQQQQQQPTTAFGQSTGTNAFGSTTNAFGATGTGTTGFGAGTTGGAFGASAAKPFGFGGTSTAPTTGFGATTTGFGQQGTTGGFGQQNTTGGFGQQAGQTSGFGGFGVKPATTTTGTTGFGGFGNTGATTGGFGTATSKPATGFSFGQPATSTGTTGFGGFGASTTPNLGGFGQTGAGATTGAFGGNKPATSTSFFGNTTGATTGTTGFGGFGTGQTNTTGGFGTGTTGGLLGQKPAGTLGGSFTSGGLGGTGFGSFGQQQQTGAFNLPGQGGLTTFATTGPQNGVQQQPLIATVDKNPYGNNPLFDLSKLSGTNADNRSGPSAVAVSGSTSKPSTPHFPVSPRVVSKIKLRGFSTAAARPTRKTMGNSSLEGISDDAVLGTGAFAPRDNNKKLVFDNDVDAASIVALVNKKGEKKKAVFDPNLEYVASKEIHKDTTSTAPLSSASLDSIHPGTSNNNIAPASTSSALAIKNGYYVSPTLDTLKGMSKESLKSVQNLVVGRTGFGEIRFEKPVDLSQVDLDDFLGNLIVIDDRRVVVYPDEATKKPAGTELNVPAVISIENCFSHDKYTGAPIRDPEHPRFKLFVDKMRQRPGVEFVSYDNSTGTWSFRAQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSE9</accession>
    <name>A0A367JSE9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ergothioneine biosynthesis protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_010060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000767">
        <property type="protein sequence ID" value="RCH92884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSE9"/>
    <dbReference type="STRING" id="86630.A0A367JSE9"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="63"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="467"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="680"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="886" mass="101661" checksum="9E265E9F65994A6D" modified="2018-11-07" version="1">MVFNDLSVRAPSPPSTGYSIIDIRTPTNGEVKDNGDIKVSRPPSPPHSADASEDAFDHSDLSKTILDSLDKPANQKSIPTYVLYDKKGLRLFDQITYLDEYYLTNAELDILQRKANELAARLENGSMIFELGAGALRKTQVILRAIEKRQIHVDYYALDLDQHELDRSLMSLGEFQYVKLFGLLGTYDQGIPWINQHFTSKGIKKAFLWLGSSIGNQTRLESALFLKRLQEMCVEPGDLCIIGFDKRNHTEKIKTAYNDPKGVTREFIMNGLDHINRIMGCGKFIDPASFAYDSAYLEKQGRHVAHYRALDNMILNYRSDTFDRTIQIKKDELIHVEHSYKYSFQEITSLLAAAGLDMAECWTDSKDQYRLVLAEVRPFKFACNVNAVREILFPSKKSLGEEEKSIQCQHCIDSKDMSAYKHEATELGVSLSESEIWPIDSLPTLKEWKELWKSWDLVTQQMINHDTMLFERPIALRHPFIFYLGHIPAFLDIQLSRHKVDIEVGPANPIQPEYFTDIFERGIDPDMDDPTQCHPHSEVPKNDNDWPSVKSILKYQQDVRKRVTDLLNLWLSEARDAQSTAWIDKVIRRRKPARALWMSFEHEAMHLETIIYMLVQSPNTLPPKGVSLPSWKFAAEAEADIIPLAEASYINIAGAASVIIGHNDREEEDSNPSCQKIQSFGWDNESPQREYKNQRSFRIQTRPITNGEYLAYLKDIGSSDIPASWLKHGDQLYVRTVFGPCPMAFAKDWPAQVSYNEANGYAKSKGRRLPTELELTRFRREIASGSRPKKVPNIGFLNWTPTPVNNEQVHYLGDVWEWTNTIWDKYDGFQPSTIYPGYSADFFDGKHRVVLGGSWATHPRIAERDTFRNWYQSGYPYVFAGFRLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSH0</accession>
    <name>A0A367JSH0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase (NAD(P)(+)) ald5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ALD5_2</name>
        <name evidence="6" type="ORF">CU097_007031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000769">
        <property type="protein sequence ID" value="RCH92868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSH0"/>
    <dbReference type="STRING" id="86630.A0A367JSH0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="494" mass="54277" checksum="6AE51FDE2DB1D2D4" modified="2018-11-07" version="1">MSNLVVETTTPKGYKLKLQTGLFINNQFVKGSDTIDTVNPATGKVICAVQAAEAKDVDAAVEAAEAAFQGPWKNMPALQRAALMHKLADLIDRDNEELAQIETLDNGKGITFSRLFDAKQIAISLRYFAGFADKVHGKVIDTEGCLSYTRHEPIGVCGAIIPWNFPLMMLGWKLGPALATGNTIVVKTSEMTPLSALKVAQLVIEAGFPPGVINIITGYGAKAGDALARHMKVAKIAFTGSTLVGRMVMKAAAESNLKKVTLELGGKSPNIIFDDADLDQAVRWAHKGIFFNHGQCCCAGSRVYVQESIYDEFLKRFKEYTSKTKLGDPHDDDTFQGPQISQTQFERIMGYIESGKKEGATCYMGGQRWGNEGYYIEPTVFTDVRQDMKIVQEEIFGPVVTVSKFKDIDDVVHMALDTEYGLAAAVFTQNTARAVDISNRLQAGTVWINCYNELDYNTPFGGFRQSGIGRENGEYALDNYIQVKTVKININREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSW3</accession>
    <name>A0A367JSW3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000750">
        <property type="protein sequence ID" value="RCH93033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSW3"/>
    <dbReference type="OrthoDB" id="2366918at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="20022" checksum="A035D4EAEAD4BF69" modified="2018-11-07" version="1">MSRLTSLPDKVIIRVTRYLELRDIIELGKAHKKLCHCIYAQPSVWTKDILFPINDPSITDQFIKQTITKITRNYGILDIRMVNLPLTWFGYFLIFDQFAHSLTSITIQSDHQLFMQLCYHLTRFATDLAILQQDNKIPSGQSIHPTKRSRSPSPRTSTRRHQSSSSFSLPDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT94</accession>
    <name>A0A367JT94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000736">
        <property type="protein sequence ID" value="RCH93138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT94"/>
    <dbReference type="OrthoDB" id="2288096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16532" checksum="7394210EB39A9DE4" modified="2018-11-07" version="1" fragment="single">ILGHGEVKTAGPTCNKAALCMDLARIACFSKEAIDLHLLESSISFQIHGFAIIFFLTRLDHDGLYIMYEIGHLEFPSSLAQLAVFTKLKNLNILLLVCHVFWKFCKKSDIPSIMQQRHRTSVKLIDLIDLTDPTKDRNRNCLVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTQ1</accession>
    <name>A0A367JTQ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000724">
        <property type="protein sequence ID" value="RCH93229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTQ1"/>
    <dbReference type="OrthoDB" id="2438895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016934237" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12747" checksum="A6054AC9D14064AF" modified="2018-11-07" version="1">MRFDFSYTVIVFLALFATVFAAHGDHASSSQVAAPSTTSSAQAAATATNGSGHGSATTTTTTTTTVKKNVGNFDSPPILMDGTLFWISLGISCGLWTTGKFIDVKIQRQERYAESRVYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVK8</accession>
    <name>A0A367JVK8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL13_2</name>
        <name evidence="5" type="ORF">CU097_014048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000638">
        <property type="protein sequence ID" value="RCH93938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVK8"/>
    <dbReference type="STRING" id="86630.A0A367JVK8"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="16387" checksum="97C41B849F7AF893" modified="2018-11-07" version="1" fragment="single">MVLKHNNQLPNQHFRKQWDRRVKTWFDQAGRKKSRRIARVQKAGRIAPRPIDGLLRPAVRCPTVRYNMKLRAGRGFTLEELKEAGIRRKEARSIGIAVDHRRRNRSNESLELNVQRLKAYKAKLIVFPRKAGKPKKGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX86</accession>
    <name>A0A367JX86_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Thiamine phosphate synthase/TenI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CU097_010532</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000574">
        <property type="protein sequence ID" value="RCH94479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX86"/>
    <dbReference type="STRING" id="86630.A0A367JX86"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH94479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="504" mass="53861" checksum="26EF44D4679FF29B" modified="2018-11-07" version="1">MSIKKIDYSLYLVTDRSLVPEGKTFLGQIEQALEGGTTLVQLREKDTDTGPFIEFALKVKELTRRFGVPLIINDRIDVALAVDAEGVHIGQDDMPLAQARAILGPKKIIGVSCNNEKEAEEAIRGGADYLGIGAVWFTSTKKLVKQPLGIEGVQRILRSIESNPVPTVAIGGINTDNAGELIKGSQTGSLCLDGLAIVSAIMAADNPKATCQQFADIIQISKQSSVNKDVTTEAVIQYAIQAMKNIKSKGPMVHHITNYVVINDNANATLAVGASPIMSTNRSEVEDLAKVNGAMLLNMGTLNDIDTMILAAQANTRHGNPVVLDPVGCGATSFRKQTLARFLDECKLTVIKGNAGEILSMAGAGGKSRGVDSVGTYDEQRIIGAVKYLARQHDCIIGLTGPTDYVSDGDRVIAIDNGHRYLPLITGSGCMVSSVVACFVAANRDDYLLATVAGILTVTIASEIASEREYVNGPGTFRAALIDELFNLTDSPEIIRQYAKIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYD6</accession>
    <name>A0A367JYD6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000525">
        <property type="protein sequence ID" value="RCH94917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYD6"/>
    <dbReference type="STRING" id="86630.A0A367JYD6"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24096" checksum="ACDA0CCAFEA4ADBA" modified="2018-11-07" version="1">MMAIHLKISVAMLIPINVLKMISILGIILIFTSLIGLLGSFYRERRSLHILCTTTVIIAFLYQVSIAIMVYNQAAHTTSWLSEAWAESSVDYRLYAQTKLHCCGFTGPSDHPVPSPTCVPHQLTNSEQPCRDPMNQYMKEELTHIYIVLFTSLAIEVLALCNSITHLCTMNPTRSWEVSPEDVEQKKFASMNEYNASAATLVNPVYSKYKRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYQ2</accession>
    <name>A0A367JYQ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000503">
        <property type="protein sequence ID" value="RCH95084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYQ2"/>
    <dbReference type="STRING" id="86630.A0A367JYQ2"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="264"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH95084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="487" mass="55143" checksum="879B16D4776DDE2A" modified="2018-11-07" version="1">MSESVWFSGPVKDAVSLVNQKDCVFLVYIYDDSDKTKTLDNTLNDEEIANHIKQHAVALKMEKDSENASLFSQLYPIQTVPILYFIKQGVIREFGTEAITKQELLEKITTAKNQTTVGQQNASLNMNTSSEASGSRTTVDTPFENQNNASTNNNANAEAAAAKKAELQKRLEEARKQRAEQERQEERAREIKRRNEAKAIQEAQQMQKDKENQLYLEKIKKERKEAEEHKRRVREQIARDRAERLAERKAEKERQEVAGSSSQQIDNTSNLNIRLLDGTNMRHQFEASDTLATVKHWIEQNRTDEKRDYKLSSLFPTRLFTEADDNTSLRDLDLCPSATIILKRSKNIALSLNQNSSSQLGFFQAGLGHVYAFFVGLLAFFAGLFGTLFPRNGYNPIQPSAASEQQGQEQQQQQQQQQQQSSAHSLKGGHRLGGTPNSSEDSTSTSVADRGQRRTPFTARFNTLYEGNDNAENEKRPTYNGNSVNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYW2</accession>
    <name>A0A367JYW2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000499">
        <property type="protein sequence ID" value="RCH95126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYW2"/>
    <dbReference type="STRING" id="86630.A0A367JYW2"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="137"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="317" mass="37328" checksum="F291DE9AD5B32816" modified="2018-11-07" version="1">MNVFNRLKSNSNASLKLPETGLVEKFGPVIHEPKLTPTNEYTPVQQASLTSEQKDKLEKLRNYIESIMLPKDHEYYPNEKGFITEATLKRYMRARKWDYENAKTMLENTVRWRRDYRPDQLDPEYIKPEAETGKMYFNGFDKCGRPVWIMRPRLQNSKDADRQIKHIVFSLERGIRLMPELVENLAIIVDFKDSSASHNPSVATCKKFLDILGNHYPERLGIAFVVKSPWFFFATFKVISPFMDPVTKNKIKFVYDSEKEKDTKSTSNEWVHIQDYIDPDQLECDFGGKFNYLFELEPYWSALLERTGNPYKVIEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYX3</accession>
    <name>A0A367JYX3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000502">
        <property type="protein sequence ID" value="RCH95095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYX3"/>
    <dbReference type="OrthoDB" id="2230841at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="54" mass="6499" checksum="E683619B9D7626BC" modified="2018-11-07" version="1" fragment="single">MKLYFELVFKLEDRFIKRTHATIKLSTTPAEMKDFFNQIQLLFSWKKSLIDSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ14</accession>
    <name>A0A367JZ14_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000491">
        <property type="protein sequence ID" value="RCH95204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ14"/>
    <dbReference type="STRING" id="86630.A0A367JZ14"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59626" checksum="ECF4BD860C2AC10D" modified="2018-11-07" version="1">MYSLLTDHPHMAVSVILSSVIGYVFWKMHQQPNTNELLPPKAPGYIPILGHILQLIKPIPIHILFSNWSHEVGPIYTCYFGAQRWIVLNSSDLIKDLIVGRGTIYSSRRMPATLTEDLFQGEKGGAFAFMPYGPKWRRFRRIAHLGLIKPKIKLYQSIIDERQASFISHLYRISTENENMHGEGIGLSYFIEHYTLTSILAIVFGDMCSFEPSDPLLHRIFSLTERAAKALSPSDQIKEFFPILKKILPNTKTKYIEISNDVQSFYNVLLQQFKTQENRQECFVKDIIDQDELTDLQIIYFVALFVGAGSETTGSTIEWAVAYLANHPEIQEKAYGEIKSQIGLDRLPGADDEPLLPFVQCIILETLRMRPPAPIAIPHATSTDDTYKNWHIPKDTIIVMNLFAIHHDPIRYPDPYQFKPERHMQFVKDTLDDRKLSQSVEDRPHLSFSTGRRVCVGIHLAERSLFMALSALLACFRIERVSEQLIEVDTVRDTRGATLAIPHYKVRLIPRHDKVVLFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0C0</accession>
    <name>A0A367K0C0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000476">
        <property type="protein sequence ID" value="RCH95351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0C0"/>
    <dbReference type="STRING" id="86630.A0A367K0C0"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="254" mass="29599" checksum="8529E874153DFCF7" modified="2018-11-07" version="1">MNSFAPELTRNSPTANASSHFKAANNKSTVIDVKKIEREINEIRENAGQRPHIDELEAADPFNRLWSAVEPLMDRLSYSVTYPTSTFNHSEEQEDEEMIRIRRELSAALHDCLPRANEKTDDERLELEDTKREYEELQQKLGQLQNQVRILEKKNMDNTTLKSSIIQFKNDVHKQAKLLLQNQEHAFMTRSAIATGRTTTGGHSTAEIMTRIKELEEKNRNLRLQNRKLDAHLEKYRERFEKLKEGAKKRQQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0N2</accession>
    <name>A0A367K0N2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000437">
        <property type="protein sequence ID" value="RCH95728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0N2"/>
    <dbReference type="STRING" id="86630.A0A367K0N2"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19489" checksum="0A57225B17853029" modified="2018-11-07" version="1">MFRFLGSQLKAYKNASTSKLSYSTVVNKTPKINVMEHVSKQLVEKANIDGRRELFSRNNPNGIKPGSIVMVETLNGPNETTTSTFMGVCIAIRRKGIDTNFTLRNIVMRVGVEQRYNLYSPLLKSIKVMQKPNEVKFRRAKLYYLRDQPGKAFQSLQGLWKQEQLDKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0P1</accession>
    <name>A0A367K0P1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000429">
        <property type="protein sequence ID" value="RCH95812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0P1"/>
    <dbReference type="STRING" id="86630.A0A367K0P1"/>
    <dbReference type="OrthoDB" id="2216267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016875884" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="402" mass="46368" checksum="653761AD80E085AD" modified="2018-11-07" version="1">MANSYRYKFTMRLFLIASAALSVFGLTQALDQHAAQPACREKYTVTKGDTCQSIASKHHVTKDHLAEWTKKLEPSFDCDKIKPGQFICVDYASIERRDAHEYRHPAHNKFHPKKPTTTHVPPPPKPTHAPKESEHEKRDFNDEHDKKPAEHDKKPKHPKKPTSTHVPPPPKPTHAPKEPEHEKRDFNDKHDKKPAEHDKKPKHPKKPTSTHVPPPPKPTHAPKEPEHEKRDFNDEHDKKPAEHEKKPKHPKKPTSTHVPPPPKPTHAPKEPEHEKRDFNDEHDKKPAEHEKKPKHPKKPTSTHVPPPPKPTHAPKEPEHEKRDFNDEHDKKPAEHEKKPKHPKKPTSTHVPPPPKPTHAPKKPEHEKREVKEPATPKKAHHKKLHHKKPAKKHTTKAKPARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K113</accession>
    <name>A0A367K113_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000427">
        <property type="protein sequence ID" value="RCH95835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K113"/>
    <dbReference type="STRING" id="86630.A0A367K113"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017043295" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15419" checksum="ECF02327E21FA2E5" modified="2018-11-07" version="1">MSRSVSFIILAILAFVALVYAAPIDSKYSSELEKRGSGMSGTFKGTGTWFLPATEGGSQGACGPEENNNSMIVAMNRPQYGSTSKKSKWCGKKLKIKGPKGTAYAKVNDACPECKKGDLDLTPAVFKKVIGDMNKGVGKITWSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K147</accession>
    <name>A0A367K147_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MABP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000421">
        <property type="protein sequence ID" value="RCH95900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K147"/>
    <dbReference type="STRING" id="86630.A0A367K147"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016826039" description="MABP domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="MABP" evidence="2">
        <location>
            <begin position="120"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="630" mass="71147" checksum="1833E60E23827D69" modified="2018-11-07" version="1">MVTVLLVLLCISIVYAYITDIKLVSCDSNHACPNYAGYKRISTDLNLGVKGAKSIFMHLKQDPREDPITDIQIVRNTNTTVISDTARWTRLDVDLNEMEDQEQGRSPLWLYYTKDTSISKNPISSIIVKEGSGPSVAPEYTRIPVDLNDGVDGYHLFMYYSQDGPKDPITAITAKQCFTSNCYMDGWERVEKDLNKGVVVGMSVYLFYKREKAKEPVTDIVVLLNDQSTPEGYTKVDVNLNSVTLRGDDIYLWYKTSNDIKNAIQDLAIQFGPRPVTPFGWEQIPVNLNSANNGKDGFGEPTYLYIKKGYQESPTVRRLEFDQEGEFKILQIADLHFTNEKGVCRDVPSEFDCKGDDTTIEYISKLLDRELPNLVVFSGDNINAAGVSDARAAVFKFTSLVVQKKIPWAAVFGEHDDKNELSREELVEVMRRIPYSLIEQGPAELPGVGNYIQKIYTNGTRAATHDFTLYFLDSPLQTMGDVQVNAIQKEQLEWVVQSDLEFQKQNSNPNAAIFFYAPVWEYHDEYPRLGDARESVSTPKNELSTLDYFKQAKAIKIASCGRDHVNDFCLEKEGIQLCYAGGAGVGGYGAAHMGWPRRSRIIKLSQHGQVLTTWKRLDDEKLTMIDFQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K183</accession>
    <name>A0A367K183_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NOG2_2</name>
        <name evidence="10" type="ORF">CU097_010816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000417">
        <property type="protein sequence ID" value="RCH95940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K183"/>
    <dbReference type="STRING" id="86630.A0A367K183"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="206"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="665" mass="75670" checksum="1C3420466D18E363" modified="2018-11-07" version="1">MGQYKKEKQRVTRDKAGGDDRAKNMRVKGENFYRDAKKIKYINMLKGGKAIRDSQGKIVQAAEYQSSEAKVARVAPNRKWFGNTRVIGQKALEQFRENLGAKVSDPYQVLLKQNKLPMSLLQDATKHTRMHILDTDPFSNTFGKKAQRKKPKIEIGSMEELMSRVDDTHENYKSDKDSSLLANKESDYTDASRAWYLQAGQSKRIWNELYKVIDSSDVIIHVLDARDPIGTRCRNVENFIRKEKPHKQLIFVLNKCDLVPTWVTARWVSHLSQSAPTLAFHASINNSFGKGSLIQLLRQFATLHSDRKQISVGFIGYPNTGKSSIINTLKSKKVCSVAPIPGETKVWQYITLMKRIYLIDCPGVVPPNSDDTEVDIILKGSVRAEKMASPEDTIPTILERVRPEYLKRTYGLQGWEDSTDFLEQIARKTGKLLKKGEPDIHNVSIMVLHDWLRGRIPFYTPPPESVEPLTEEQEEEKKKRKLGVEQIFGKINVTAEYMEDDLANNAQLIEEERAKENAKKEEEAANKKSTKSAAKQTTDWDEVFEDVVGEQGPVVKAPVIEGEEDEEEQGIDSELELSEDEGGNNDEEEEEEEEEDEVEEQPAKKVKTNNNETEVPKKGKVGVHYYETANVKNKNRNKVKPDDEKKKVLHSRLKGSAVAGKRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K245</accession>
    <name>A0A367K245_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000390">
        <property type="protein sequence ID" value="RCH96227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K245"/>
    <dbReference type="STRING" id="86630.A0A367K245"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="477"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH96227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72263" checksum="DA3BA7A179344708" modified="2018-11-07" version="1">MDRRKEELEKKRQKLAELRRAREERRALLESQSTHSSSTTTTGSAGRDRKAIDDLVALVLGERPSTPNATTASGSDRGSDAGSEFSSRPTSANFGYSSPGTPISATDARLSMVSAASQPNQSTTTTPHYVAELTETQALIADIPPLERVVYSKEIQTTDGSLEAPQVSEEEIRKQITEEFEQREKQKIAQLEEEIKRLEQEKHEEIKELTEEEAKVIQKSQEFIDFVDTSTKLVERALNEKYDFMKDYTLGIDVEQDENSGKHVKFVCNFWDEKWCKNRSVTDVNWSLKYPELVVSSYNKNPLAPNEPDGIALVWNLHLLDRPEFIFHSQSDVLSVMFSKFHPNYVIGGTYSGQIVLWDTRAKSLPVLKTPLSAGGHTHPVYSIEMVGTQNAHNLISASTDGFVCSWQLDMLAQPQDYLELLHSAHNKTDEVSATCLGFPDNETTAFWVGTEEGNIYQANRYDRAGSKAGINQYDTYRGHHGMVTGIDFHPLHGPVDFSDLFLTSSVDWTVKLWRAKSISKTSTQASTVTPLYSFEHSDDYIYDVKWSPVHPALFGTVDGTGQFDLWNLNADTEEPFVSTQVGSGKALNKLAWDKEGRKTAIGSSDGHVYVYDIGEVANPKPEDWSLLQKNITEMISNQENPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2Z6</accession>
    <name>A0A367K2Z6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CDA2_9</name>
        <name evidence="6" type="ORF">CU097_014711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000359">
        <property type="protein sequence ID" value="RCH96536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2Z6"/>
    <dbReference type="STRING" id="86630.A0A367K2Z6"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="5">
        <location>
            <begin position="112"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="44659" checksum="2B07B7D2E8EE7ABF" modified="2018-11-07" version="1">MMAIIVNAATPPSKHRHFDDDDDDDDDHHKKPKNDDDNDNDSKKNPDSETTTPKKKSWLEDIDFDAIEGEVRPVGSGICKDAKCDGTDNDQCFETCGNLATHEDIYGCKYDKTWALTFDDGPSEFTQELLDILDKLDVKATFCVMGSHVKKFPEIIKRAYESGHQIASHTYSHPHLMSLSNEDIVYEVRATEEAIEDVIGVKPKYIRPPYGEADKRVKGLLKQMGYKVLMWNVDPTDYDVYNLKDGAKRIQDTFEKVLKNNNSSLNVHADDGFISLQHDLYRVSIHQVPQIYRALRKHDYSLTTAAECIGDDEPHIRMAVPRPAASASNSSLSGKSLPTNLSGSNLSDRPNNKALFDKQNVDRNVNKANKQESSGSIVASVGYISTLLAAMAAWINYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3M0</accession>
    <name>A0A367K3M0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_005577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01000339">
        <property type="protein sequence ID" value="RCH96760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3M0"/>
    <dbReference type="STRING" id="86630.A0A367K3M0"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH96760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="451" mass="52850" checksum="5D39AC18B0E1D1A0" modified="2018-11-07" version="1">MTSIKETNELDGVDHLFSDDELMGEMDDEFAKVNIQTSGLYNSFIEHESENTVFLYRMFYSSLFPYKPYFYWLNQDTTPTRNFTHREFSFTLPSDIYIRYKSFNGIDDLKKEIERIQPTKIDIGAIYSIKPNLKKTVPEKAFKPVEKEFVLDIDMTDYDDIRTCCSGGDICHLCWEFMTVAIKIVHAALQEDFGYKHILWVYSGRRGVHCWVSDERARKLSNEGRKAVINFLNVVKDSAQKARRVRLNTLHPSLKRSFDIISQHFDHLILENMGILNTEERCRKVLDIIPDGQAKEKTEKMWLDHPEKSTAQEKWDYMNEMVEKIESKKRFKDNVGRDIMFQYTYPRLDVGVSTNLNHLLKSPFCVHPKTLKVCVPIPIEDCERFDPLSVPTLSSLSDEIYAYNNNPTTDKNVADYKKTSLAPYIEYFDNYAKSIMLQTKREKRDADSMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3N9</accession>
    <name>A0A367K3N9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_003363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01000339">
        <property type="protein sequence ID" value="RCH96759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3N9"/>
    <dbReference type="STRING" id="86630.A0A367K3N9"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="9">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Mur ligase C-terminal" evidence="8">
        <location>
            <begin position="292"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="417" mass="45973" checksum="6B4A714E16124503" modified="2018-11-07" version="1">MDFGLERTRRLLDALDRPDERIKIVHVAGTNGKGSVCAYIASVLRTCGYSVGRFNSPHLIEPRDSINVNGQAISQIDYNHAVETIDRLDKSEKIGATSFERLVATAFYLFDQHHIEFVVLEVGLGGRYDATNAIGRPMMCIITAIGMDHANILGNTIEEIAYAKAGIMKPGCPVVIAPQDNSAALDTLENYARQIQCPYKLAMAAEWIGPQMCSLSVDKQEYTYPIQLNGDYQRMNSGTAVTALDWLHQLGVIQLAADQLAAGMAKTLWPGRLDWITSARVPKLKMFHLDDILVDGAHNPPAATALHRHVESLRKKRVIWIIGATAGKDIKDMLHQLVKPEDALLAVPFSQPEGMPWIQSIDPSEIASHVKGASSWCSLEQALKEAGTLRQPKDIVVLCGSLYLVADFYRLCESNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Q0</accession>
    <name>A0A367K3Q0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000332">
        <property type="protein sequence ID" value="RCH96844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Q0"/>
    <dbReference type="STRING" id="86630.A0A367K3Q0"/>
    <dbReference type="OrthoDB" id="10581921at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="190" mass="22358" checksum="4BA7E4C85FFEDDDF" modified="2018-11-07" version="1">MTTSRLPIPSLAELTYNVNKLSQPNIYLYHQLQPHHHPLSFQPSSSTVHHDYPPTPPQPPLTQRFCEPEAENDRLLLKQVYEQCTVIHKEIARYRVDALTETDRNKIVDLVYCTTESMMRSLKTLNDQLFQYHDQEIDNTLSSSQPIRSLQDDPNSSKYEMIRQARNLQDSSMRPKYRRRNVKKAFTSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K469</accession>
    <name>A0A367K469_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000319">
        <property type="protein sequence ID" value="RCH96978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K469"/>
    <dbReference type="OrthoDB" id="10316463at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47568" checksum="35BDF9D2660686D4" modified="2018-11-07" version="1">MSSIQFLESFPSLQQLYLHKYRVVSMEEFMFIFDTCLDLQLAAISLHIDRIPNTFIRPKPYPSLKELAIASYSHPIHEGTIDYITQKFTGLCKIRIQVDSSPEHDAYNVAYSRLLETHLMRSGQSYEFQLTFIHNDGWTDTENSSIRIDTTRACLSSIFGTRQTSSNIYHYLIVRVLDDRAKRLKLETCLKKVKIDLSRCRTEISLPHAGIGSQLNEYLDDTASNIYELHVNGLSNPKEKPLQGLHTAIEKCSRLEKLTLLACKLQSFKGCLSLSVQTVHINHVETYPTFFKDLVVSFPNLKYLCIGHTTIVNDCLPVKPVVIDLLNLNLESLSLYNLKQQHCDFDRKPCMILVTTSGKTTYFKKCLFDNPEKLTREDAIEEEIRADPMHQLHIRCRKIHQLWLYGIKFEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K492</accession>
    <name>A0A367K492_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COA3</name>
        <name evidence="11" type="ORF">CU097_011500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000309">
        <property type="protein sequence ID" value="RCH97082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K492"/>
    <dbReference type="STRING" id="86630.A0A367K492"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH97082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9454" checksum="F7A9E1A14B91B56D" modified="2018-11-07" version="1">MNNQPTREKLYSQPKGYGFSPALERTRKPFAVRNMLTLAGLLTFTGSVYAYSLFAVKQDDFSDVTLPSQLPGVHDVTKEQKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4Z8</accession>
    <name>A0A367K4Z8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPB7</name>
        <name evidence="8" type="ORF">CU097_008829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000293">
        <property type="protein sequence ID" value="RCH97257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4Z8"/>
    <dbReference type="STRING" id="86630.A0A367K4Z8"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="19115" checksum="3FDCCC2F2EBF9B37" modified="2018-11-07" version="1">MFFLKELSHTITLHPSYFGPNMQDKIREKLYADVEGTCSGRYGYVVTVVSISRLEKGKVLPGSGLAEFKVTYQAILFKPFKGEVLDGIVTTVNKMGFFVDVGPLQVFVSSHLIPSEFKFDVNGNPPCYSSEDQVIQKDVRVRLKLVGTRVDATEIFAIGTIKEDYLGVLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6H7</accession>
    <name>A0A367K6H7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FMP21</name>
        <name evidence="4" type="ORF">CU097_010867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000242">
        <property type="protein sequence ID" value="RCH97862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6H7"/>
    <dbReference type="STRING" id="86630.A0A367K6H7"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10502" checksum="2BC058172D4F7124" modified="2018-11-07" version="1">MLRTTLVRTYSSLNRPGPLPLGNKKQQKEMLDLIRKRQEQDVQSTELHQDAIKKPQAEFEGDVNPKTGEVNGPKTEPVKHNDWSFGGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6L6</accession>
    <name>A0A367K6L6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000273">
        <property type="protein sequence ID" value="RCH97481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6L6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="8254" checksum="75651088425270D1" modified="2018-11-07" version="1">MTASLNTWIKSLRSYNELKKEGSSKKPKPKLSRKRKAGGSKEPSGSRKRARSNVSDFASSSAAQPVPVPPSQPSAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K731</accession>
    <name>A0A367K731_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000229">
        <property type="protein sequence ID" value="RCH98033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K731"/>
    <dbReference type="STRING" id="86630.A0A367K731"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="2">
        <location>
            <begin position="189"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="3">
        <location>
            <begin position="414"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="4">
        <location>
            <begin position="561"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="838" mass="96034" checksum="5B6EFC772CA99B23" modified="2018-11-07" version="1">MPPIQQLHEAFLSQLLYKEQPIDNILDTSVDKTTLTQVLSHLDAKYTSLQSELYQYVQQHLDPFSTSHQAVQDITTKSRELCASVEQRYDSISQTHSQVESTLDEYSQALYNAQLGKSKVNILEDIIQILEILESVQENTRQSQFIKAVEQLQTVKMPTNLPTSTADLIKHKVNQASNHIVNQLHETLHSIVHFEERTVKVTKGDLECVLTSFNKLGRLTEELMSIKRIVFKHIIDPYFECGCRCTVESKHTDEEAILTIKKLPYEEEEGASYRIDPVTMIDCINNMLSFFFEHLFNHKKNEMTRLFGHLFLSDLMNLMLSKSVVPAVPSSRHQLSSFDRVMESIISFEQTCQQCGFDLLENPLRTFAENIDRHYAKKRREVILKEGRKVILRKLYDAEPTQIELEDGQVQEFQITQSPQLLSVLISDTLAETLELEQQHPVSATQLTEGVQDLLDLYRAIMPSYHRPQFLSNPASALVFRNDCFWLANQLKWTARRYPAIKDTLHEALKRLEELGKAWHELCMMQCMDKIQRCLDRFDGFVGGAEDTKVQQAWDQTMSEVIQLAHSFAAAIRPVVDIRVFTDILGRVIDSLLNRLIGDIEDLTDIGAEESHVIARTLNSIAQLVGVFDHPKHGEATDSYVSQLVPNWQKFWLLKDILEMSMREIMDAFRRGQLHMFAKSELEHLLCALFADTELRRTNIEEIKSGQPPVNLSGIETIMHAEPTKAPVPTVTPSAAVSTINAPAPVQTLMNKLAYSPDDDEETTTGWDDDDDIEIPEVDNDKEGWDDDDELEIPDIDENLEKKMDEKKEKSKPIEEDIDLTLSDNEGWDDEDLFKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7F1</accession>
    <name>A0A367K7F1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000223">
        <property type="protein sequence ID" value="RCH98100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7F1"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="2">
        <location>
            <begin position="62"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="3">
        <location>
            <begin position="561"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="782" mass="89740" checksum="86721D57CB24584F" modified="2018-11-07" version="1">MPTFANYPSALPYLDELHKEDLLAELVASLKGQRTRRIRTKQEDTSNPFINSINHAAKLNLTKEDNVTYFSTCDPCLDLYYASYKVSDDRDLRRMLENAWAVDADLTLHIIFYIRSIHRGQSLTAPFMSAFSWLLQYHPRTALANLHVLVDGTVRTDAALKAQEREEYFRIKAEKEGREYKRRDYGQLLERRDFKSHGCWKDLCTILTIYAQGELRGPSDAIYKALKWPKTATTYRYAINERQERNRRRKEEMTREEAKKDAEIYIKKGAEHNAKAQAKAKEAKEKTRRERNERVTKLLQADPLYRALHFTIARLFANQLKADMVQLQKNKDAIEQGVLKGRHALGFNLSLAGKWAPSLCRSHDKHTFLATSIAELLFPPEKHQDDGESREHYLNKIRDLYRKQYLVPLRDALDIVEHYKAEGKWKKIDFTHVPAICLKHNWARFYKHAPYAVTTFLNGSPLYVEKAKGEKRTTFSSNALPRRIKISGETTLPGDLLANIFDPEIPKTLQPIVNFARDAKRKILDIQTEITNRQWENLIESFRKTSLLNTGKSSNTVDLGECIAVCNLSDAMWYSRSSKLVHHGVALSLIIANLAKPPFDGSIIAYSKGPTAFKLDTSLPFDEQARQIMQRVNNSNGFDLKGVFTDIILPLAVKNKVKPKDMIKRMFIITDNNFNFGELEAEKLETAFGLIRRRYHEAGYEVPEMVWWNVADPGSCTMYDLKAPVSKDDAGVKMLTGISANMLKTFLDGGDIDEDKAKQETPLDFAKKAVYHESFKDLVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8R0</accession>
    <name>A0A367K8R0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_013811</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000187">
        <property type="protein sequence ID" value="RCH98568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8R0"/>
    <dbReference type="STRING" id="86630.A0A367K8R0"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="156"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH98568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="418" mass="47874" checksum="B5A3249BF17ECD2A" modified="2018-11-07" version="1">MIRRGLFQLAQKTYFSTATPRLHLAQAKKRLQGTGNTPQRAGIANDKQVYLDWNAQKTSVYHHFWLRDHCRCEKCYHPVTRQRLVNTFDIPRDIHPTSVESTEAGLQVTWPDGHQSTYAWDWLYTHSYSPILRASDPLEGKRPKLWDASLKLDAVPHEAVMNTDEGLRQWLDQLETYGIAFVEGVPTTVEATEALARRICFLRETHYSEGIWSFTADLAHADTAYTTLALGAHTDNTYFTEPSGLQMFHKLEFNGKGGDSLFVDGFHVAKQLKEESPNAYQTLSKTLIPTHSAGDENVLIAPTPRAFPILNHGPDGDLYQIRYNNDDRSTMNHLSSSQLDEFYDALFMWHKLLTSAKNELWDSLPPGRVVTFDNWRVLHGRSAFTGHRRICGAYLPWDDYKSRCRTMRLSSVDKDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8U8</accession>
    <name>A0A367K8U8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000180">
        <property type="protein sequence ID" value="RCH98662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8U8"/>
    <dbReference type="OrthoDB" id="2280705at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="309" mass="35549" checksum="8163D18F1B79B578" modified="2018-11-07" version="1">MLTAQEVAWVIYAIFFTALSLALVIRSRHHVLLLPFVLFSILISIALIVMLSAHYNYILAETWASKSLALNILPVISLLVFLGIMEAQILFIRQVATALNNRERWRSIYLRDSEKQEGFPVRQRKQSLHPWNYWTSITILIIYALVVLCCIILQLLAFRMSSVKTRDLGMAICITILFILSSTNCIVIWNSSASSTIRQNRDDTLFLRCVPALFSIALTGMCILAWIHYGAFGYSLAAWILVESLLVYLPFILILCMSIHVRKFKSMGRQYPNQYSPKTIREISFVTKRLTAEEVNQKYTYPPPSYYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8Y3</accession>
    <name>A0A367K8Y3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000183">
        <property type="protein sequence ID" value="RCH98620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8Y3"/>
    <dbReference type="STRING" id="86630.A0A367K8Y3"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="88965" checksum="BB08885E26C8D13E" modified="2018-11-07" version="1">MGTTDSKLAFRKGVFRLFEERNLPKNMDDYWTLFWTLPESIDDVYTLISIHDIRRTRDTAIENLETLIDRLLEQMNSILNSTNTNQNIQLLNCCRILSRVMPFIFESPEHAEWEDRFFWTPRLIERERTEDGQKPQYDSLPPRGEMMLSLCLKSLFLAGFTIPSSIGTADNKVNYVIWETGVGCSTPIGSSRDNDMNRIEVLRLLTVLLSKSMYTTPTQIISKEDRWLTYMITKTEKKIVLAFLCSMINISCKYNPLGWTVVPYNHIMFSDPRELLVGHCLRILLIILDYRLPLTRNTSSTDVIVEKMEDLNLSPKQNDGQVESSDNVYRYYLSKLHRAQDFQFLIDGIYRILDNPMQTLNNYIPGSLKRARYHVEMLMLCWKLLETNTRFNHYLMETERGLDLMVVLVFYANENKLDPSQVGLVRMCAFMLQTLSSNRLFGVKINKSFDGHASLPASSKIPNFQGTYADYLILSIFSLIATSRGTLSTLYPAFIMTITNISPYLKSISPIASSKLIALFSSMSAPGFLLADEANHKLIEYLLEAFNNMIRFQFSFNSRFVYALVRNALKFQKLADFNLDAALSEKSSNIARKHATDDEAGLSEKAKGKLPEGSTLTRHSSSSSQLQSNNVSFPGIKNGFIPTENWVNSWHSQLPLDTILSLIDYLRPQLDKPGLTGDQIVEYINNLSLSDIPLSTPAHPVTVRKFQWTDTLMIWFQSMLWGHTYISSVSNYGPWTGTQIKLFHIKQQQPAVPDNTPPLPASSPTSGHSSRPALTTSRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAB8</accession>
    <name>A0A367KAB8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Survival motor neuron Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000141">
        <property type="protein sequence ID" value="RCH99182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAB8"/>
    <dbReference type="OrthoDB" id="2279078at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21691" checksum="A64C1AF653489F29" modified="2018-11-07" version="1">MSIKVPDTWDSDIIEYWDALLKSYKTCHEQPASFDTFEKVTQSIMDNLPKETLKQQEEEPRKRQKTKEDQLSNKKVHFKDQYEGQEEEQYEQEEEQYEQEEEEEYEQEKEQYDQEEEQYDQGEQEKQAENINEQTQYDYSIPSPPPVSAGDDDGLSNVIMAWYYAGYYTALYQSRHGSRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB40</accession>
    <name>A0A367KB40_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000130">
        <property type="protein sequence ID" value="RCH99329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB40"/>
    <dbReference type="STRING" id="86630.A0A367KB40"/>
    <dbReference type="OrthoDB" id="2289488at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28659" checksum="68DE12F2B0CB453E" modified="2018-11-07" version="1">MPYSIQQLDSSIDLFAPPVPTSIPTYISTKDDQAKQKADNVVHITITESGTVVYTHTATSYSYIPTYSTVSTIPNNDPTSSSRKPNNNSNTNTGAIIGGAVGGGVALIALVGLLFLLLCRRRRRHSHLYGKAYAIDNESNIKYSCAEPNASGSANPLNNGLVPRQLIAPLQGVADEPNIRESKYVGNVFYEDTADPSYNNLYTKPYFALNNTTDSMNSDSSPSTTVEGNTILPSYDISRHVPNEIDPILDRPSQERHVPHLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBL6</accession>
    <name>A0A367KBL6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain transcription factor ste12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">STE12_2</name>
        <name evidence="9" type="ORF">CU097_015227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000117">
        <property type="protein sequence ID" value="RCH99530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBL6"/>
    <dbReference type="STRING" id="86630.A0A367KBL6"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="716" mass="81194" checksum="58E2F2201A909A84" modified="2018-11-07" version="1">MLNSKPYTKKKPSDKNNSNPLGSASYGLPAPTEENIMIRQTQIDEMKLFFATAPHQWETNKFIKRFHLPNGESISCVLWDNVFFISGTDIVRSLTFRFHAFGRPVINPKKFEEGIFSDLRNLKPGHDARLEDPKSELLDILYKNNCIRTQKKQKVFYWFSVPHDRLFLDALERDLKREKMGLESTTRAIAEPAASLSLDSTQELFDELRKSMSLVKTPLTNSLSMNQVTPKNEDPWPTRLTIKRSRVNSVPASLGQQQKHQLAAHREYRLKSIEKDYLEPISSAVNQLDINRSSRSLDLKKQKAIFGSLSLFDGSPAYKQRRRRTVSSTQSSPSLHSAGGPDRVRRHDKCHHPTPAPSSINFSRVPSFGNPPPRKSTNSGQSRLAMAAYKAGLTQTLPSATLHEYHQQQQHPMDWRSSSSTSSTATTATASVDFYPSPCQQHLEPVHMFTCHLCGKCFAQSENLEEHHRLEHSADMNTSITAMIDDKDDDDDDSHIKDNSHYSSFIIHQDYPHASNSTTSTQDSFFHSPPGKSNLTGTTTTTTTTMTTTTTTTTTTTRKAIKTGHVHDTGTSPEPVASWPTLALDEKPFIDIDFQMQDVTNRDDCLFSVYNNNNNNNSNHKHDCMYNPIISSTSSINSLTHEENDASSSLASSPTDPFHSMTLFSPFKPIFQEQEEQQQQQFSFDDYYYYAPYTMDAYYHHHLYTPLNDMNFVFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBM8</accession>
    <name>A0A367KBM8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhizopuspepsin</fullName>
            <ecNumber evidence="4">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PEP2_4</name>
        <name evidence="16" type="ORF">CU097_015430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000110">
        <property type="protein sequence ID" value="RCH99632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBM8"/>
    <dbReference type="STRING" id="86630.A0A367KBM8"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="88"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH99632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="403" mass="44520" checksum="A73DE4446AF38AD4" modified="2018-11-07" version="1">MKVLTTFIAITVAFTTVSNAITFKVPIKKIKESPNEQYARFISSNSVALQKYVETERYQDTKSKIFDPAADGTVEHGVPLSNYLNAQYYGEIGIGTPAQTFTVIFDTGSSNLWVPSTHCLALACLMHRRYSSSKSSSYQKNGTEFAIRYGTGSLEGFTSQDILHVGEIDIKDQGFAESTNEPGLTFALAHFDGIFGLGYDTISVKKTVPPFYNMVKRGLIDEPVFSFWLNDVEQGGESNGGELVFGGIDENRYTGDITWSPVTRKGYWEIELQNIKFNDQYLNTFSMGAAIDTGTSLLVAPRSVAETINSQLGGKLDGYGQYTVDCSTISSLPEFCFVFSEKEFCLQGTDYILQLDEECISGFVGMDIPPPAGPLWIVGDVFLRKFYSIYDLGNHRVGLAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCK0</accession>
    <name>A0A367KCK0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_015341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000092">
        <property type="protein sequence ID" value="RCH99907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCK0"/>
    <dbReference type="STRING" id="86630.A0A367KCK0"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="225"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="442"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="682" mass="78164" checksum="B4E357D857516E37" modified="2018-11-07" version="1">MPPNPTHVPTRASLRKFSLNHVPLPVYLGVDIEVRDGMKSYYAISVHDGFYTTDYYEGELVEHDIENDSVEKMVKDALSKLTSIVSLYSMAQNYKVQLIACSYDIARDYLKQKSLVITEEMNMMNEFWKQLDAIPFRVTTHGESCDERASAAVRKAVMWLSPIYPGNLPRISVGYRHEVEGRQTQVQIKMVNLWEYKETVCDETWRVFTEMVNEFKEKKLRVSFFNSTPQGGGVALMRHAIVRFLRLAGVEVHWYVARPKPEVFDITKRKFHNVLQGVAPPDVYLTETDKQIFIDWSNENAKRFWLDDKGPIKNSDVIVIDDPQVCGIIPHIREHAPNTKIIFRSHIEIRADLIKEYPEGPQAITWNFLWNFIQHADVFVAHPIKNFVPEVVPTRNVVLLPAATDPLDGLNKQLNDWCKTYYQSVFNRVCVDLGVNEVDWYRPYIVQVARFDPSKGIPDVLEAYRLLRAKMDGNFEDAQTPQLVICGHGSIDDPDGTVIFEQVQEILNSEPFTGIASDIIAVRLPASDQLLNMILRGAYVALQLSHREGFEVKVTEALHKGVPVIAYRAGGIPLQIREDEDGFLVPIGHVEEVADKLFELFNNPELRDAMGEAAKKCVTEEYFTVWNSMSWLHMFLELTQNQSEDEHNGGGLLDMNTLSHTNLGHQRKVSDLWKEKYNYCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD76</accession>
    <name>A0A367KD76_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000074">
        <property type="protein sequence ID" value="RCI00203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD76"/>
    <dbReference type="STRING" id="86630.A0A367KD76"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="16917" checksum="A126BCE3F68898E3" modified="2018-11-07" version="1">MPQPLVSNLLLPELERQLKEDKNLWPNVKGLFIVTVTKKKKPQAKWFLLLQGNNVLPYISTNEEEVRAGIKGKVRTVHIQVDDADLLNFITGGMTGVRAYMTGKIKVKGDLLLAQRLEEVFEKLGGRERAIEFIKKNEETFTAVNKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEI5</accession>
    <name>A0A367KEI5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">ERB1</name>
        <name evidence="10" type="ORF">CU097_011716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000049">
        <property type="protein sequence ID" value="RCI00626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEI5"/>
    <dbReference type="STRING" id="86630.A0A367KEI5"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="187"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="702"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="789" mass="91231" checksum="58AA4CFBC9C5A69B" modified="2018-11-07" version="1">MAPRKKTATLATNGKTATNTAKKVENGKDKKPLKRRAEELEEDEQSDQEFGSVDIDMHSDDEEEQSEKENDDDEDIEEFPEIDLGDDDEDEADSEDMDENEEEEEGDEDDMDEDEEEIDEDAELEAELEREQNESDDEEEEKEFKIPPPYRQRYSKEKLPDIEANYDSDTSTEETENTIGNVPLEWYKDLPHIGYDIDGKKVLKPATADELDKFLATVEDPESWKTVKSDKEGKDIVLNDVELDIIQRLQRGIIPDSTYNPYEPTVEWFTSKTEVMPLSARPEPKSRFIPSKWEAKKIMKIVRAIRQGRIVPRKPKDEKPRFYNLWGDDDVPREDHVMHIAAPKMKLPEHDESYNPPEEYLLDEEETKKWHEMDEEDRPKNYLPKKHSSLRHVPAYDKFIQERFQRCLDLYLAPRVRKNRLDIDPESLIPKLPSPKDLRPFPTRQSLTYEGHTARIRSLSIHPNGLYALSGADDHTCRLWEVLTGRCLAMWKFEAVIHAIAWCPNPDVWLFAISVGHGDVHLISPPKLCSPIQAMNTDQFTKAGFANPAESKQNVSWIRASEADEEKYGYKVLIQHSQAVKQITWHRKGDYVSTVAPDAKNLAVLIHQVSKHQTQAPFKRLKGLVQKVAFHPIKPIFFVATQIYVRVYDLMQQQLVKTLQTSVKWVSSIDIHPGGDNVIIGSYDKRVCWFDLDLSSRPYKSLRYHTKAVRQVVFHKRYPLFASSSDDGTIQIFYGMVYNDLLQNPLIVPVKILRGHDVKDSLGVLNIEFHPTQPWIFSTGSDGTFRLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFV2</accession>
    <name>A0A367KFV2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000027">
        <property type="protein sequence ID" value="RCI01047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFV2"/>
    <dbReference type="STRING" id="86630.A0A367KFV2"/>
    <dbReference type="OrthoDB" id="10258358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32920" checksum="3E0099B2D7ED90AB" modified="2018-11-07" version="1">MSVSKVVTSQVKKKYFTELPSIRVLSRSPEDRPEVTVYVKGFLSEGESPENFQDWMHSHRLLVLSPTHRWGSSALGYSWPSGSSSLPIPLASLGSIAYLIAKNINQLKNLRFPTPASMVAALAIDVSLHAGRLAYQFNVANQESRDRAEMLAWRLLNLRKKHEYVRVVGHSLGCRHIVEACTLMDAKERPDSIHLCAPALVAPDIIDQIRKNTGGLGRLNTAIYYSEKDLTLGILLRAILGGQQAIGEIGLPDKVGQDKDWLDPSVKIMNVSKSLGGFYIGAHTDYANKFHYFAHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG30</accession>
    <name>A0A367KG30_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000021">
        <property type="protein sequence ID" value="RCI01183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG30"/>
    <dbReference type="STRING" id="86630.A0A367KG30"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="110" mass="12052" checksum="286013D14B385005" modified="2018-11-07" version="1">MATEPPKTTPITVSELRKYDGSDPSLPIYVAIKGDVFDVSNNTASYGKGAGYNVFTGKDSSKALGKSSLKPEDCIADYSELTPKEMETLDQWYAFFAKRYNIVGKVVPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG56</accession>
    <name>A0A367KG56_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000022">
        <property type="protein sequence ID" value="RCI01159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG56"/>
    <dbReference type="STRING" id="86630.A0A367KG56"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="304"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="77922" checksum="9F2BA0DC50AE58FC" modified="2018-11-07" version="1" fragment="single">MSTFTRPTFNADDDDLERLQQEFFANQQKPAAKVIRKGDSSQQQNKRSVFAERLAKEKDTGMPTLEDVEYEPVMDPHPEPHVPVSKKMIDLTSMLGQVLGDITEHTVDKVTPPSLPEEMPNKPARGQKDGFPKPVHRSEFKRRLEAKRNNTKPPRPEAPPQVAASTPVKASSESLLDSSMYADENNRRIQEMSEQELEEARAEIMNTLSPESVAILMKGLKKKHTEPVENKKKVTFQEPESSKDEGQELLEMKNKYFSDVPIENEKLAWIDDRFLTNELKEQLQKEKEEDKSQASEIEKVYRKVRFDLQGNIINDHEDIPVHKGLHHHGDEPEKAGYTLAELFYLMRSQVPSQRAIVLSTVSRIITKAKHQQSDETWWKILRVFTGKEHAAPIYLRSALDDRHLIALVGAVKALAALVLDLEDDWEETLIAKAVDFNRFLGHIAHPVLPSGSRALERKGLNDKLSELVDRVRQQSGVADEGEKEDDAALAEQDLARALIKMNILPRIRYLIASENRSELIQGDPASVELLVRILVQLAEAGEDVCDSIEEEELIEPVVQWGIVKTQWPMTDDGNVFVYPSLAAVRLLTVLAQGSKHIAEEIVERMTSLLPFLVTNPDIACDSLKRRAYALQLETLKLLRVLASYGFIAPILESSQEPVMDWLRVVLDKKQRDTRLQGIRASAAIELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGM3</accession>
    <name>A0A367KGM3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MNR2_6</name>
        <name evidence="8" type="ORF">CU097_015870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000013">
        <property type="protein sequence ID" value="RCI01375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGM3"/>
    <dbReference type="STRING" id="86630.A0A367KGM3"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI01375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="504" mass="58375" checksum="59197CA016BAE457" modified="2018-11-07" version="1">MSSLRRRTTGSSKKEHPHYLSSHIDARRQSTCPSFLSKASSLVNEEEEEENVESDVLYPQYRASKDDHVDIEAFNRMVQQHNRKLSSGTLQLSRTLSKQNQLYGPSRYTDIHILPSGTRFRIYSSKKNTHISTNLDQLLSEEGQNALRSVVTTKGWWLDVLCPTTEEMTIISKTFHIHPLTTEDIQAQEPREKVELFPNYTLVCFRAFDIDAETEKIIPYNFYSLIFKEGLLTFHYRESDHYDTVIKRSEQLKEYMSITPDWLNYALVDAVTDSFAPIILQVEMEAVSIDELSLMLKKSEQADMLRRISRCRKRSTQLSRLLTSKLDFIKSLMKRYEDKSREFLLLEQQHATKYIPQQKQAKDDSVNPPAIVIPLPGTINNLVEEKKAFNDVLLYLGDIQDHIVTMLQNITHYDRILHRAHTNYLAQVNLELTQTYNLTNNVMNRLTFLTTVFVPLSLISGLWGMNVKVPGKDYQDLIYFFWILGGMALYCTGCILFGKRVGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGM4</accession>
    <name>A0A367KGM4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MAD1_2</name>
        <name evidence="10" type="ORF">CU097_015815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000013">
        <property type="protein sequence ID" value="RCI01374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGM4"/>
    <dbReference type="STRING" id="86630.A0A367KGM4"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="41"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI01374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="724" mass="84183" checksum="384FA658C2002280" modified="2018-11-07" version="1">MLDETPTKRKRVTADILEYSTSLNSLSTSDLTNGKLISQDVEKLKHENFTLRTKLENLKSVHELDIQNKGAMIKQLTEKKADAEARAMYHLKKSQEANELLFTATKDHEEERNKLKDEIDLLKAKLSELTASKRAVERENERLVAEKELDKSQSDNTINSLTSSVNSLKNMLKERSDTIQQMSEKMTTLTSTISELNQKVEDASKYPGDPKEYKKLEEQYLRVCEQNQELVSESKKMTNKLSYYEDIVNELAKFKDDNMTIKESLEEISKIRKENTRLTLEVAKYKAEREEWTCYLDTHPELGKRPPQSVIRELMQKVLEDKYLRKENEALQQRISDAFKITFELENHIDELKKKVLEYKTQYQLVLVAKDTIARDKETLHLHIKLLQNQLKMYDQEEKTYMTTTYDEKKSARIEELEALLKQMQERIEEQSLELANIKLNASPNTEVPKGPSDEVSSGASIKEMLANIVENSKTHFESISKLIVENDMLIKKMQGAEKRCEILSEAMSQQQNMGAKDKSDTSSGQRILQFTENPDNIIRAVRSDTLKRLQEENRLFMEQKLNAATDSNDYIPVPKTSILNFRKEIESKDKRISRLLTVWENKLRSLHETIQGLLGYKVTLRNDGIASLESSFVDKEHLMFLVNINPDTDEARIRITGSDKDYYMDTLLQDAYHTYIEQGKSIPAFLNAANQELYVQYKQKQEENDSDHRTVMEDDEMYYEDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGW4</accession>
    <name>A0A367KGW4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013133</name>
        <name evidence="5" type="ORF">CU097_015788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000456">
        <property type="protein sequence ID" value="RCH95535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000011">
        <property type="protein sequence ID" value="RCI01417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGW4"/>
    <dbReference type="STRING" id="86630.A0A367KGW4"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF6">
        <property type="entry name" value="SENSORY HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="117" mass="13189" checksum="18748BE2D5AFFA54" modified="2018-11-07" version="1">MPDVFEHIELVKSGVKALELLRCRPFDLILMDIDMPILNGVETARHIRSSTEFDILLHNRNIPIVAVTTNDTKEWRELYTNAGMNGCIGKPVSLNDLKSTLSNVLDLDIPQSPYTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHJ3</accession>
    <name>A0A367KHJ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional regulator of nonfermentable carbon utilization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ERT1_5</name>
        <name evidence="12" type="ORF">CU097_015796</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000001">
        <property type="protein sequence ID" value="RCI01647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHJ3"/>
    <dbReference type="STRING" id="86630.A0A367KHJ3"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI01647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="52031" checksum="7445AEAB6D1C9727" modified="2018-11-07" version="1">MKQEQTKTTSAPRKKKAARACIHCQKAHLTCDDSRPCQRCIKRNLSTTCTDGARKKAKYLQDIDEPVNTPTTAYSPQTSVSTPMSSFTQGETSDFQAQNFMSTDAQSILNAASNNALLPIENYNYGFGSNATNLEYSILSNMLGSPLVDAASTSTPNVQQNTLNNIWAPSPIVDNVNILRGDPSFLSNHNTTQLMSNASATNAFINRNNSVSNSPGNNNNNNGNTTPKGSSVASVASSSMDTSQISASGISTLSAYGDGAVVAKVASPITATTGPAVKRRNQIITPEMAYASATKPFSYAEGYHYLINYVKTRMSREDLMRISRALALFRPSVLASMMNLTEDDLIFTEKCLQRTLLEYEKLISYSGTPTVVWRRTGEIALVGKEFSLLTQWSRDMLLNKKTYIYELMSNPSAVEYWEKYALHAFDNTDSAVYSTCILMSPTKRVVPCTFCFTIKRDIFDLPSVIVGNFLPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL15</accession>
    <name>A0A367IL15_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005257">
        <property type="protein sequence ID" value="RCH78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL15"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="96" mass="11127" checksum="0FC782010EF19F92" modified="2018-11-07" version="1" fragment="single">MYFEDLQRHLQVKADSGVNTDVVMCIKLEGITKGYSLVDRIGIPWAFLYDTIKRYKDNGEDFNCIFGLKNGKYFICAFVEEAVEDFSHFQNNAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP41</accession>
    <name>A0A367IP41_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004602">
        <property type="protein sequence ID" value="RCH79271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP41"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="57" mass="6904" checksum="606F38E3705EDE00" modified="2018-11-07" version="1" fragment="single">MQCVDHCDDPDPKKRIYFEQPLWQTLNMFVGEFAVWIVYLYQLYEKRYQTTIAPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPF7</accession>
    <name>A0A367IPF7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_003094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004429">
        <property type="protein sequence ID" value="RCH79545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPF7"/>
    <dbReference type="STRING" id="86630.A0A367IPF7"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH79545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="178" mass="19715" checksum="ED629DC695A9C356" modified="2018-11-07" version="1" fragment="single">SSSTHVDILAVRPGTIDVCKHACQNLEIDVISLDLANTKTAPNFAAAQVAVSRGIFFEICYAQSFKNPGKKAAFFSNVKRLVDVTRGHNLFFSSEALRALDIRKPADLRILGALFGMTQDQIEASVTLNYAKLLKKAETRKSTYNAAIRNQEVSKTEKRKQENQGQQNKSNKKAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQR5</accession>
    <name>A0A367IQR5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004140">
        <property type="protein sequence ID" value="RCH80028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQR5"/>
    <dbReference type="OrthoDB" id="2268828at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53594" checksum="69B7552EB793DBF7" modified="2018-11-07" version="1" fragment="single">NDTVNTSLNSINSSTNEPLKDIDHESSAAINAEQGLINLIKHLRTVLFKILADVNASEDDINRAHNNVTVAESRLERVRTLLASDINQNKVHMKRAYDWYSLKKRKITTTELPLFKLTHFKKESEPSSDKKMKFYNTVDHFFDDFELVFRINEVNVMVHWKDYLNLCVCEDHIDWFKETVFANNAITYDHAKELIRNQFENTSLFLTRSKNFLACKQDINESISDFASRFSRLAMIARYSDGPMLALIFIDALHDCHHNSITTILSSHFGAKFMSQVKSYRDIEKLICHLKGPVVPTTEKKRFSKSPSDNMQKKTKTTDKPSEPRNCRYCNDKWFPGHRCMEFLKERNKVQMARLNEKQTHKHVASDAWQNYAKDLNKDLDKNMEIGKCYMTTKAMALIDTGATISVINKSHSHLIGVTVPIEIRYNGKTISHPFEIMEFDHDDKMNCILGSDILSSLGIGLTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITI1</accession>
    <name>A0A367ITI1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">mRNA-binding ribosome synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PES1_2</name>
        <name evidence="2" type="ORF">CU097_005009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003643">
        <property type="protein sequence ID" value="RCH80978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITI1"/>
    <dbReference type="STRING" id="86630.A0A367ITI1"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="214" mass="24658" checksum="1B9E4FD14D21F8A0" modified="2018-11-07" version="1" fragment="single">MGKLIKKGTKGNAANFITRQQALNKLQISLADFRRLCILKGIYPREPKNKKKANKGSTAPATFYYVKDIKYLLHEPLLAKFREHKAFTKKLNKVLHKGEFAAAKSLEENNKPIYSLDHIVKERYPTFIDALRDLDDALSMLFLFAMLPTDDKIKADVVSDCRQLIAEFQGYVMRSKSLRKVFFSIKGIYYQAEIKGQTITWIVPYQFSQNIPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUH6</accession>
    <name>A0A367IUH6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003477">
        <property type="protein sequence ID" value="RCH81343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUH6"/>
    <dbReference type="OrthoDB" id="2263516at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="101" mass="11591" checksum="BE1C19465E7D3148" modified="2018-11-07" version="1">MTTSPSLPPLIPPHQLKTNHRQSFCSSSDDDDSFMMDEHKFWQVHSSTLIISPPLKSPTKNKVPLNLASQVKQILGSTIDQVDEEIEQEWNQRPRTFLSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV82</accession>
    <name>A0A367IV82_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003363">
        <property type="protein sequence ID" value="RCH81603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV82"/>
    <dbReference type="STRING" id="86630.A0A367IV82"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="139" mass="15191" checksum="43CEFBF6082B4618" modified="2018-11-07" version="1">MLRQPIQRITSSNLRNITLKSLAASYTTSLQPTAKSVAPTAEQAANRATTWSENQRAKADALKGPRFEQMDLSTQPNPMAAIELIAEEPIRFVNKRIAHCDGGGGPLGHPKVYINLDASGPQACGYCGIRFQKLDDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVN6</accession>
    <name>A0A367IVN6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003300">
        <property type="protein sequence ID" value="RCH81748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVN6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="14058" checksum="5DBF7A833D88638A" modified="2018-11-07" version="1" fragment="single">SMLPFLLPLLVFKNPSTLLKSNVLTLLLVVSTLVSTSVVVKSSLKNKSLVLLLSTSRPTCPLTNLSVSTLIFVPPPLVKPSLKLSLITGNSCPVTHWKPVTRSTTLSVMSVPERVLLLIFLVLTSTMTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVZ9</accession>
    <name>A0A367IVZ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003253">
        <property type="protein sequence ID" value="RCH81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVZ9"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7746" checksum="EE8F80BF8099B16D" modified="2018-11-07" version="1" fragment="single">MSIMNNTQNIDKYVDYDTFLVDNFDATRYVEEIMKQSEIEDESDVTAAFSRLTFGIDILNKQIQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW81</accession>
    <name>A0A367IW81_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POLR2F_1</name>
        <name evidence="7" type="ORF">CU097_002056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003218">
        <property type="protein sequence ID" value="RCH81934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW81"/>
    <dbReference type="STRING" id="86630.A0A367IW81"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="11100" checksum="0574CDE9F9FFC701" modified="2018-11-07" version="1">MDEASIEIIEKGSEEQGSSKVRQTTPYMTKFEKARILGTRALQISMNAPVMVELDGETDALVIAMKELREKKVPLIVRRFLPDNTYEDWDVKDLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXQ9</accession>
    <name>A0A367IXQ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RHB1_1</name>
        <name evidence="14" type="synonym">RHB1_2</name>
        <name evidence="13" type="ORF">CU097_003067</name>
        <name evidence="14" type="ORF">CU097_012054</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003012">
        <property type="protein sequence ID" value="RCH82442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01001053">
        <property type="protein sequence ID" value="RCH90884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXQ9"/>
    <dbReference type="STRING" id="86630.A0A367IXQ9"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH82442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="187" mass="20805" checksum="C0695C7FDE517689" modified="2018-11-07" version="1">MSVPNQAKTRRIAVLGARAVGKSSLVIQFCENHFVDSYYPTIENTFTKTIKYRGNEYTVEIMDTAGQDEYSILSSHHATGMHGYVLVYSIASRSSFDMIKIIRDKILDFTGLEGVPCVVVGNKSDLNIQRQVSTEEGKELAQQWNCPTIETSAKHDENVSKIFDLLIAQIEKANKPPTEEKGGCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ57</accession>
    <name>A0A367IZ57_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002824">
        <property type="protein sequence ID" value="RCH82972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ57"/>
    <dbReference type="OrthoDB" id="2288752at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="257" mass="28344" checksum="AF9B63789D3CE450" modified="2018-11-07" version="1">MLRVQSILYIERLWSSPHVHHKQYTSYLSSSEPAEVQEVQESEDLIQQVQAQPKAIATEQVLVQEDIPAMDTTAEADGNQVAAMTTTTTTTTTVTTVTTTEAEADKDTPIGVSEVIEVTEKQAHSESGYNTGNEIEQEVFILQVDDKPVLENMQVVEESVVLMVDTQKSSSDEDNSQEDEEEITSSSPVLANTSIISSGSSLTPVTPTSIDSPLELRPTSTRNSIFRRETTKLNHKRKTLTKKLKNVLGHPTKRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZW1</accession>
    <name>A0A367IZW1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">LSM5</name>
        <name evidence="12" type="ORF">CU097_006361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002812">
        <property type="protein sequence ID" value="RCH83001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZW1"/>
    <dbReference type="STRING" id="86630.A0A367IZW1"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH83001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9423" checksum="C022B5FA4C6D8695" modified="2018-11-07" version="1">MSTSQLLPLELIDKCIGSRIWVVMKNEKEFTGKLLGFDDYVNMVLEDVTEYENTKEGYKTNKLEQILLNGNNICVLIPGGTGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0J1</accession>
    <name>A0A367J0J1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_003722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002695">
        <property type="protein sequence ID" value="RCH83339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0J1"/>
    <dbReference type="STRING" id="86630.A0A367J0J1"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF124">
        <property type="entry name" value="SYNTAXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="25968" checksum="B0D1D770DC8DBB34" modified="2018-11-07" version="1">MMDTKLLSRLDLLADNTLSVIFERNRLKDLKLDVEKYETNIQKNLSQLKDGIQQLEQQLSEEEQTDTTKDTKVDEDKLIQLQLKVDKLEALLSNQTDPAARDLLLGNNHKKSPRFTPIDTSQMENSQILQLQQRIIDDQDQDLDHLSEAIRRQRELGLMIGDELETHAILIDETEEMVDRTDERLRRAKKKLDYVGRKVKDNKSICIVIALILIFFILVALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J121</accession>
    <name>A0A367J121_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_005480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002600">
        <property type="protein sequence ID" value="RCH83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J121"/>
    <dbReference type="STRING" id="86630.A0A367J121"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="19492" checksum="4A7FD7AC9542D4D0" modified="2018-11-07" version="1">MSLVEIKQYGNRYLVFNVKDVERLRKEFRIVGALCGTLPGFPQQNTFYGLPLSLSLEEVKTVIDLKVAKVTNTLSPLPSINNSLFRYFWSLGYYVTSGYKFGGDYLLYPQDPTCCHSQFIVSIMHFDQNMTTKDAVQMGRLATNVKKKFVLAGSKNETEDEVAVFSLSWAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J161</accession>
    <name>A0A367J161_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_007096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01002595">
        <property type="protein sequence ID" value="RCH83650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J161"/>
    <dbReference type="STRING" id="86630.A0A367J161"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="75"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH83650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="467" mass="54276" checksum="489FCF5715B98D2A" modified="2018-11-07" version="1" fragment="single">EEIKSHPFFKDVQWQSIHTSTTPPFVPPISALDDVTFFSDFPFIGYTYVDKLLEEPSREVQDEQKIEQQQNGDQSEDCARQMNDLKQQVSILQDENEKLSTKCEASVCKMNALNEHIAHLEQKLTAHQEESLKDTKRHLERIKALEDELSARKKESQQMMTKYKQTLEREYQQNSQAITQKLDDHMQHLRTMESENLKLKSENDAQKARIAALEKELMAATTHGEEAYAQLEERYDAKLKTQEQEYQANVQQLHLELNSLQQKLQEVQQENQSRSRQDELSSNKSKILSVMWQRDRDHLHSVQQTLADTESSLAAAKREVARLKKEIKYYQMNSLRKEKKLYFPIEINGDVSVIPNLIDSIKAPMTRRRKRIDLSASLSNLSSLASRDISSDHKMNSTRPSINDKQVKEIESQIKIEKEFIASTQRALTARARLSRVKTEFDQELHESITKSNAKILSLQEKLKQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1A8</accession>
    <name>A0A367J1A8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MNR2_2</name>
        <name evidence="8" type="ORF">CU097_005693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002640">
        <property type="protein sequence ID" value="RCH83501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1A8"/>
    <dbReference type="STRING" id="86630.A0A367J1A8"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="489" mass="56587" checksum="0E78D3E241C79709" modified="2018-11-07" version="1">MDPSFPYYPPHTENAYDQSIKGNAGSSLLLTTDPKDLDKLFDRSIEAEQDICFPTKRPNSSSMSSTTTATFSPPPRKHNGHNSFQNNSINVNALSSWFTDIDMHSSMTQYYQPTKQTKKKLSLYGDNHHIVEDSKEDRYMYFHPDTGVIRGKSLLELKLPPHLTVEQLLLKENFWIDITSPSLAEMKAISKIFHIHPLTTEDIMAHEIREKCDVFRRYIFICYRAFLHDNYQLKPMTFYNIISKRHILTFHFGHVPHTEHVLERVIQLQDYIEVVPDWINYAIMDEITDSFAPMIQQIESEVDTIDDLVLLYKTDQTDMVLRIGTCRKRVIQMVRLLGTKAEVVKALMKRIEERTVRSDSLEEEANDAEMGRIYPDVGLYLGDVQDHILTMLQNLNHYETVLARSESNYLARISIELTQTSNSTNHVIGRLTIFATILLPMNLITGLWGMNVKVPGKDYDNLVYFFWIVFSLVAFAILSLTFARKMKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1C9</accession>
    <name>A0A367J1C9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress response protein nst1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NST1_2</name>
        <name evidence="2" type="ORF">CU097_005557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002569">
        <property type="protein sequence ID" value="RCH83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1C9"/>
    <dbReference type="STRING" id="86630.A0A367J1C9"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="660" mass="77367" checksum="66C0FC2D8B81B049" modified="2018-11-07" version="1" fragment="single">GGILTVADDLLKNDGKKFLDMMERLAERRMQKEDISLDQNSNYFQEEEDDEDGYEDDEDEDTRTEEQRMEEGRRMFQIFAARMFEQRVLAAYREKVAQERQQRLLEELAEEDRLREEREAKKQLERERKKDKKRQLKKQQEEERLALEAKKKAEEEALRKQKEKKMEEERQRREKERLRKEEEKRQREEERQKKEEEKKRKLKEEKEREKKRREKEEKERKEKEERERKEKEERERKEKEEKERKAKEEKERKEKEEHERKEKEQQERKANKEKERKEKLRLEKEKVDEQEKPKEAMVVTPTATTAPKQPIIEKQPVLPQYSHIPPDDFENRQQVLIEALVGSTSRPSNFVEPNNIQHSLAQLQLSQPSGTPASFLSTSLDHTSPLSDANSSVLGLFNNRSTAPPSTSLLTETPSTRRSLTSIAPIGQPIHNGRRSSVQPVGTIGSLPDDAFLSGKRTETEGMTARSFFSSFLFGEPTKYHNNTPPPHVMSHDYDTRLAQDNRRFSGDGQQQQQHTPGWTNAWTASSLLTDNVHGKLFGDALPDRTAMTLERVKVAYQKLNEITQVKMFTGYHTLVQLHRMMNDLYIDFPIDIRELYEILCSPLSGFRCFHHGQHGIVVLYDNSSMASTTNFSSPPHSSLLLPSHPPPSLQPGNNPPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2I6</accession>
    <name>A0A367J2I6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic phosphate transporter pho88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002452">
        <property type="protein sequence ID" value="RCH84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2I6"/>
    <dbReference type="STRING" id="86630.A0A367J2I6"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22199" checksum="4E0BB6DF830E6D15" modified="2018-11-07" version="1">MSKVVKFLNSPYFGIGSFIFFQQLSKFLHLDSHIQSLRFLYLFAQFVILALHFYLIYVIKKKNDQTILKYVEPAAQSWDGTETPDQLVNTTVMEYDINEVKKSMKQSFVGIALIAFIHLKFGYIQPLLVQSILGFKTFLMTKEARLHIWGAKATGDLRRPFRIEAPFGLVSEKKQPKTDKGSIKKAEKALKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2S4</accession>
    <name>A0A367J2S4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002420">
        <property type="protein sequence ID" value="RCH84247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2S4"/>
    <dbReference type="STRING" id="86630.A0A367J2S4"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="456" mass="50696" checksum="31F283AB37A3008E" modified="2018-11-07" version="1">MTTSPVSPSAPTEPAKPKQQMSSNHLSVPNESKENENSDDIFMELNENVYLQIQYIKITEEHTPKKRRAIFIVPDPDLSDEIGEESSATWVELLGDVFYVGWLSNFTHSAEITSSDGIGKYFAWFVVMWWTWCASALYSSRYDSGDVTHHVYKIIELCGLVIMAGASPNYQNNPKWFIIGYIIMKAVNLVQYSIIFIVSLGAHFKSSRRPLGAYVAASAISIVLWGISLLYLPSEGVSDDATAVKRYVLWYISIGLELIVYMVLQTNSRVSLAASHLGERFGLFTLIILGENCMGFISTVAELNMSNNATEPKAMAAIMFSVAIIFCYFFMYFDDFSGEFVAKTKMSSLWMYLHFPLHLFQVAFGIALTSLIKKVISDDGGEAVAEHASNTTAEHATTVASHIARLVASEHGSGHDSEPTESFLITFFWVSAGLILCFNAFIKLVNTPIKSGKIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J626</accession>
    <name>A0A367J626_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002108">
        <property type="protein sequence ID" value="RCH85402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J626"/>
    <dbReference type="OrthoDB" id="10379501at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="36414" checksum="B6173922E15CBC40" modified="2018-11-07" version="1">MIILFKKGKSYFKKKTLTEKVPNPPDQDASSETCSTYDTPPSSPETYSKPHTPSSSSEACSTPPTSPTSPKIYSKPHTLSSSLVPTSPETYSKPHTPSSSETHSAELKTKLSPEEVSNAAQARNADIPDTPSSISETHSVPISPSSSSETRTPDTSPESPHAREGNQNDNPPRQLGPNRSISGLEPFEIEEVSRKLIKKYKGWNKEAKKRRYTRLPEHEERYEEKLERYITQLRDEELHRENVPVNRETVVANLDTFVIFLERLDALNERTAANISELFYELFNDRNSALFGEALFASNRTKKKQAVEEHIILKRYEESNPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6D9</accession>
    <name>A0A367J6D9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002089">
        <property type="protein sequence ID" value="RCH85476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6D9"/>
    <dbReference type="OrthoDB" id="10371928at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="12610" checksum="E158981F4DCB2CAD" modified="2018-11-07" version="1">MVESTKKHKKSKSKKGHKKNKKEGKKHSKTKNESTTVSFTQDMSSKSVEDTVHAQAIPRTTLTVKVTKTAEAPLPIQTADQHILIQPPKEFVPGNDLGNVVDPLLTFIGYAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J717</accession>
    <name>A0A367J717_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002050">
        <property type="protein sequence ID" value="RCH85629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J717"/>
    <dbReference type="OrthoDB" id="5573535at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="377" mass="42484" checksum="01C878D3698B2629" modified="2018-11-07" version="1">MSKRSNEETVVKEGVNKRSKTESHAPDCTDETCTGCDIGEVEIAFTNKTDDGEVEEVQPNAHELMVLAIDEAQEGDNDMARRLFDMSLEKFQQDEPDNRTGYAACLVQLGKTIGVEESLREGLDILRGERNKDSTLKLKVAYAALALANYLRMQQIATFAPQEANLYQENAELDEDAYEELLSKQKVTPDEEKLYKEAIDLVREVIKDAPLSDIQSVISELRTYALSLDLPVQKDHANVVLDATIEFIQQVPEHQDNWELVTVWAACLAHQEKVVDGTQKRVEVISKAIEMAEKANQLHVDKVGKDHPFMWELLAGLLMTQISLVDDEDEVMALYERAVSSFKKAHELAPEKVELLEMIKVIEEMKDAEGNNDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J795</accession>
    <name>A0A367J795_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FCJ1_2</name>
        <name evidence="12" type="ORF">CU097_007945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002008">
        <property type="protein sequence ID" value="RCH85817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J795"/>
    <dbReference type="STRING" id="86630.A0A367J795"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018054">
        <property type="entry name" value="Chromogranin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00422">
        <property type="entry name" value="GRANINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="244"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH85817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="585" mass="65214" checksum="72C3EDC25D699E21" modified="2018-11-07" version="1">MLRGASKLRATCVSSASKKSVGLAASKRFYTSTTTEEITNTATTTKSSSVGKKLLWLTALSATAYSGATYYALKNEAFHDTYTTYVPGGEKLLDALEDWAANERVKHYYRQAKEMKDMASVHAETVKRFASDTKESAQDWYEYVSDAIAQLKGEKAPPIAPGTGPSPSARRRKFKKEALFANVIHTTEDQPIPQFTPSEQDVLNDLGKTVQDLVQVLNNAGMQGYAKRLVDLASRDIESLDKAFKLIKEEDDKARAEIEALEKELATVSQHVESHRQEVSEKVKALQEKDEARVNKYVKTIEAEIANETAKVDQEHRDILAKELAAQRQQKLVELEEELKNKAIEIQANYVEQVKQQVETERGGRLSQIETVAAKQAELESLAQADAELLDDSRKAHQLLVAIDALKKAALAGQRTQFEVELEAIKKLSTKTPFAKLGERQSDELLQLVASSIQQHVAQYGITSLAELSARFETVAREVRRAALIPDEDASMISHLLSIILSSLMFRKKGLVPGDDVEARLARAEYYLNTEKDLESAAREINQLTGWPKRLALDWLDAARRHLEVKQALEIMKSQASLISMLQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7F4</accession>
    <name>A0A367J7F4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002020">
        <property type="protein sequence ID" value="RCH85759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7F4"/>
    <dbReference type="STRING" id="86630.A0A367J7F4"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016611936" description="Nodulin-like domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53910" checksum="4A64E53E5C4C3A15" modified="2018-11-07" version="1">MNNRNIILAASFLTALLVANVSGPQYVYPTFGPSLANRFHWSSIENSVVGTSVFVGVSFSGPLCAYLVENYGFRITLTISALITSICTFLLSATYQDRLPSSYLLCAFYLVCMGASSAAAYICTLDSQAYNFKLYRGMSMGLTSASLGISGLVFSQINDKLFKPKGDQDGHDNSTFEFLIFFGCTAAAVTFLGSFILGPIEHTKHELPLAEQQPLVASNSANYASTAGSVYSFSTSSTQYEEEVQDVKGVPSKNVINYPKNIQIEDEETNLSGLTVFLDPVGFSLCLSLFIILGLGYVYLTNVGGLLISLSTDHLTPNETQHLRNLHISIFSVSNCVSRAVFGTLSDIFQRRIGIHRMWFIWFAAVGLMTSMVCLPISVSSDKDLMTYSVTIAIVYGIVFAIAPAIISEFGIKTFARNWGWMLCAPAIGSQLFNLVFGIVYDRELSRQGGQVCHGMACFRNTFIIGAIAAGLCLFIITAAIYRKGIYRFQSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7F8</accession>
    <name>A0A367J7F8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine-specific demethylase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KDM8_1</name>
        <name evidence="1" type="ORF">CU097_009776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002004">
        <property type="protein sequence ID" value="RCH85835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7F8"/>
    <dbReference type="STRING" id="86630.A0A367J7F8"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="218" mass="25495" checksum="06F13A1169EBD2AA" modified="2018-11-07" version="1" fragment="single">MFQQLFQQLKDLFEDKDKTKDLQQCGDSVYTLFESARLDVLSRKENCNEKIDALIDYCNETILLYPFKDVPDHWRRMLIDVGLLKTMAQLERCKDVQSLIWDLDTCSIVSGAPERYEIVTDILEQLQKHYYKDNKDSDMSLASKDDIWMDIKYPIKSMAPPTFEWFLAHCNQDLPEPIVIKGLIDHWPATERWKSTRYLLSIASARVVPVEIGSSYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7I2</accession>
    <name>A0A367J7I2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001986">
        <property type="protein sequence ID" value="RCH85907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7I2"/>
    <dbReference type="STRING" id="86630.A0A367J7I2"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="245"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH85907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="641" mass="71990" checksum="0973749FF1DCE514" modified="2018-11-07" version="1">MENLLEQMQHQDKPESIADEPEEPPRKRREPSIAELPASIEHSKTASYLGSSSGYYLVRDILSTDKEVIEKVDQYPRISSVTGVENKGPVAFRKINTTDDDVMIVCDKTLAEHMGQVEADKSRINSDIAPKELLDELVLKFFELDHAVLPVVDKQPFLDAYYGRIQPPPATVLMYAIWAHTCSLLSKEDPLFVKYNVDREQLYDILWEHTSSILRFEYLTPRYATIQALVLICTYPTTYKTFHRNWIRAGMAVRMAQELGLHRTMEKLPLTKEMTEARKRLWYCVYITDRWCCAVLGRPLAISDADCDIELPDITHNGNDYTVFVNFVKLSGILGEVLSRIYSPKAKSHGSKSMQTYHTVQSIHFMLNDWLQQLPNHLRIESQDVNTALNYGNIKFEEAGPLMICYHFVLILLYRIFLVANKSEVLPELFDRANECCTTAAKSIVDIARRLSASAIVCFGVNFAGYAIFQASLIHVYNSTSSNPEVARAAKSYVNISIEECIKPLAKTVHCIPKTSLGLIQALMELTGANKDGPKSTNDASNDIANNATTTPSTLRPSPPKPQPSPMSMHAIVSDWESNTGSNNTYNNGGLPAMQAPESFNNNNSTAAWQSLFASAGAPFFENECDWQGKLSMFIVIPLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7T3</accession>
    <name>A0A367J7T3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RFA1</name>
        <name evidence="15" type="ORF">CU097_007568</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001990">
        <property type="protein sequence ID" value="RCH85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7T3"/>
    <dbReference type="STRING" id="86630.A0A367J7T3"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="195"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="304"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="459"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="610" mass="68192" checksum="2F9A0550B700025D" modified="2018-11-07" version="1">MSQQLSVGAIKAIHFEENSNPLATNPIVQIINIKALPVNGATRYRAIVSDGVNFMQAMLSTQHTGLVEQGQIKRNSIVRIKEYACNMLSNKKVLIILNLEVVISDVDAKVGTPVSLDPTSASPSAANTQSRPQSQAQPQQQQQQQQQPLFNNTSTSYSSASPTFNSPGSFNSRPNMQLESSLTPIKNINPYQSRWTIKARVTQKSQIKQWHNNRGDGKLFSLNLLDQSGEIKATAFNDQVDRLYHMLEEGKVYYLSKARVTMARKQFSTLDNEYELTLEAGTEIELCSGDSAIPQMNFKFVKVSDLDNIEAGSTIDIMGVVIQDNGVTEIVTKSTGRPTKKRELSIVDESGKSVRLTIWDKTAEEFDSNNSPIIACRGVRVSDFNGRSLSLSASGTLKTNPDIPETQRLRQWFNSNGNKDFGTFTNGGAMGENMSRPTNKVNLLQVRTEDLGSGIRPDYFSFKGTVAYIKQEMLAYPGCPECRKKLLQEENGWRCEKCQKTFTTPEWKFILTIGVNDPTSQLFFNTFDDVGRALLGTSANELMEIKDSDISQFQKICGRALFKSYHFKARAKSETYNDQSRTKYTIMEAHPIDPIKDSQELVDEIEKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J850</accession>
    <name>A0A367J850_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001942">
        <property type="protein sequence ID" value="RCH86090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J850"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016861056" description="SGNH hydrolase-type esterase domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="45360" checksum="0CD8FDE4D7F4FF5F" modified="2018-11-07" version="1">MRSLITTFLFISLCQLSLGQAIKNIVVFGDSYSDAGNHQKLTNGPLWSQNLATSWDASLYSFAFSGAVCSNRMYSTKQFIPSIEDQIEMYYNQSLQLNPEETITIFWVGVNDIYHIYEQDDDDKGSKLKKVVDCISTNIRMVRRVFSTNRYIVFGIPPLEKMPYFTDKPDKEIKEHAANMLNEYLSNEVQKLNKHIEHLKLDFMDIHRLLDDIVAQPDFFELKNAVDPYWDVCQGQCMDDVNSYVWWDKVHLTGGVHRLIAESILQSSNEGAHLPDIEQVNKMIEQTKYRSPQYQPKAQTGLMQKLIEKMQKEKETTKEQEKELEQDEQENSSNLRYYVYFGISATVIVCIGFILFNKKSSNRASQLASLSNLLKKDDRGRFVPLRNMDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8E0</accession>
    <name>A0A367J8E0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001923">
        <property type="protein sequence ID" value="RCH86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8E0"/>
    <dbReference type="STRING" id="86630.A0A367J8E0"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="404" mass="44445" checksum="DFE90B1E986BD242" modified="2018-11-07" version="1">MSISLAACNTEKPAGVPVQLEDCQRVKLFQPYTQKSVELHNRIVVSPMCMYSCQNGFLNQFHVMHYGSFAFKGAGAVIIEATAVVPEGRISPNDSGIWSDDHIEPLSHVVNIIKSQGSVPGLQIAHAGRKASISPPFKGDYIESEENGGWPNRVMGPSEIPFADHYPKPNAMTKAEIQATIKAFADAAVRADKAGIEILEIHAAHGYLLHNFYSGNSNKRTDEYGGSFQNRIRLTLEVAKAVRAVWPEHKPLWTRISCTDYVNPDPMGSDPDGWSIDQSIELAKQLKQVGIDLIDCSSGGNIKGVQYPNQPLYQVPFAEAIRHQAQIATGAVGLIVEGEDAEKILQEEKADVVLVAREFLRNSTFALCAAQALDVNINWPKQYSWAVKKARRHNTTADEKTAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8X0</accession>
    <name>A0A367J8X0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001921">
        <property type="protein sequence ID" value="RCH86191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8X0"/>
    <dbReference type="STRING" id="86630.A0A367J8X0"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="58488" checksum="30A74E64053069F8" modified="2018-11-07" version="1">MMQMQQQFQQMKLAEHHPSQQQPQQAPLAPVSQPLLQQQQQQQEQVASFEHDKVQMPTEKTQVSPTSLQNTLKNISLDPIGSSHASPVLRTSNILTGGSGWGSVPGTPLASDAPSSPWGTIGASALPSKVTDEFQPKAPGAQSPRAPSSPKKAAEKPKFKPIIESFTDIQAEEMEREKVKEAVKATEPVKPKTAPAKAKVETKTPAVVAPKTTIISLREIQEEEMRIAKEKKEKQAKATSTASTWVSTSSPTTTTVTSLSTWSQPVVEKPLSLREIQEMEEKNAQNKKEIVPEVPIHTSSSSGSSTILWGVVAPNKTVTPANGTTSSTAVWSAAVNSAPKKTLREIQLEEELAMKKKNATKAVKADTPTVASIVASSKPLVASTAIPSTGNEGWTTVSHVRAPKPAPTPAPAPAPVVKEPTKWEPVKPAVRAPVARGPSEDFRRWCRKALRGLNSGVNEDEILEMLLSFPVDGSSAEIIEDVIYANSLRIDGKRFAQEFMRRRKADIAGRTDIVLAGLEEEDDDDFKVVTTKKNKKKTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9F0</accession>
    <name>A0A367J9F0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001841">
        <property type="protein sequence ID" value="RCH86563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9F0"/>
    <dbReference type="OrthoDB" id="2285800at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="159" mass="18451" checksum="73E181C9D9C6735F" modified="2018-11-07" version="1">MSLQFISLTPEEDDYDYNNNSFDQEEETYWIDDCECQENLATILPLNPEECTIDEDNHIQSTDVHVFFEELGYFTEEPEPIDPTRDYEAEAKLLLEERDKTRKKHVDITMPSLDDTHTPSGISSTCSSFHAHDFTVPSNHKIPSYVYASHHTDHLSIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9M1</accession>
    <name>A0A367J9M1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_007805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001827">
        <property type="protein sequence ID" value="RCH86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9M1"/>
    <dbReference type="STRING" id="86630.A0A367J9M1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000276">
        <property type="entry name" value="Acyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="15">
        <location>
            <begin position="5"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="224" mass="24178" checksum="7C1CC97D070733BE" modified="2018-11-07" version="1">MSLTSVVIGARAKHTATVFWLHGLGDSGAGWSFLAEELGKAFPHVKWILPNAPVAPISMNFGYLMPAWFDLHGLTKESLETEDEEGMLASLESVGKLIRDEVDSGTPANRIVVGGFSQGCALSLLTGLTSEYKFGGIVGCSGWLALSKKISQLASNANKDTPILMCHGDRDQVVKYEYGKESAETLQSLGYNVSFKTYPGLTHSANAQELADISEFLQKVIPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA38</accession>
    <name>A0A367JA38_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001795">
        <property type="protein sequence ID" value="RCH86786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA38"/>
    <dbReference type="STRING" id="86630.A0A367JA38"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="371" mass="43462" checksum="FCAAC090D5321DA1" modified="2018-11-07" version="1">MTDSLVTMPMSDDDSMTVKLVTKRRSSQVFTVILKPYNPHFQTRTLEIRDKTRIKIGRQTSSKTLPSPYNGYFDSKVLSRQHAEIFCDKQKVYIRDIKSSNGTFVNGYRLSGEGEESEPYEIRSNDKVEFGVDIDNMYHKVSCVVYIYPLPLSQVDDNILQEIQQPLYETKLSRKSSVDTISSQHSVQYPQEEKKAPNRLESVLLQLQNEIEKSKRVQDELKGVKETILDLDRTVQQDNKHNLQHRLNEAEMTIKSFHEKWKYQQQSIETAKGEIRRLEKQVSELNAVKLKLTNELEQEIKKSKLLEEQLNNNKIPWMQVTKRKKKQGNTYLVYMVLHNIHHNYSLAVEDKAYNMNHNMNKDKGMTLFLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAS2</accession>
    <name>A0A367JAS2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40s ribosomal protein L44e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL44_1</name>
        <name evidence="5" type="ORF">CU097_008714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001739">
        <property type="protein sequence ID" value="RCH87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAS2"/>
    <dbReference type="STRING" id="86630.A0A367JAS2"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="12048" checksum="B170450DF2E8637E" modified="2018-11-07" version="1">MVNIPKTRNTYCKGAKCRKHTPHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTACKYKMQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB29</accession>
    <name>A0A367JB29_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001715">
        <property type="protein sequence ID" value="RCH87162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB29"/>
    <dbReference type="STRING" id="86630.A0A367JB29"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="326" mass="36583" checksum="CCFE73D89DF78C4B" modified="2018-11-07" version="1" fragment="single">YERKWEIDSLASFISLSYRYWEASGDNSFVNNSVWIDAVDSILTTIKKQQEPTFNETTGEPLPTDYKFFQTTDRPTETQFLLGRGQPVKYTGMVKSLFRPSDDATLYPFFIPGNAMLSVELGHLAQLLNSSSSRSNSKIQGFTSDSLRLSKQIRDAIYKYGIVDHPTYGKVFAYEVDGYGSSLIMDDANVPSLLSLSLIGFLDQNDIIYQNTRRLVWSRDNPYFFSGPRGSGIGGPHVGLNYAWPMSQIVRILTSSNDNEIKEALDTILASTDNTGLIHESLNVYTNSGGDNNSGYTRSWFAWANGLFGQAILKIANERPYLIFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBF1</accession>
    <name>A0A367JBF1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001739">
        <property type="protein sequence ID" value="RCH87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBF1"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="30787" checksum="640A6DC9A8509EAB" modified="2018-11-07" version="1">MQQALKSKQLAEILTTTFKTKKLVELREIARSSGIYQQGTKSDLIQRLVNELPSKTPSSILSFDLGYRNLAYCVVTQDATILDWARIDLELTTFHPSTVAPVVRKFIRDRIEHNMKAVDLVLVEQQRARSNGSWTVLEHTLRVNSIEGMIWYGLYETANNIKRPDLDMIALSRQKVDAAWESELQQVAALTAVNSRTTYKKKQATVRLVQNWLDEKENSVIKLDDRLKNMFREEPKKDDLSDCLLQALAWYKWQQFRQSYVHLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCH2</accession>
    <name>A0A367JCH2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001631">
        <property type="protein sequence ID" value="RCH87559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCH2"/>
    <dbReference type="STRING" id="86630.A0A367JCH2"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41968" checksum="0509F0C190F55F6D" modified="2018-11-07" version="1">MERDATAPTDRHSLKRPLTTEAESSNKKKILSLSKKKNEQQPIVTKLETYTCPICEVDLTDIKSSYLRQKHVEKCIDNPSDESIDTLDCFFCGKVLSHMNMARRQIHINHCLDNVEEELKKKKVGQLSLLETLIFCPVCHESAPFDRRCLKQKIVHIKQCRSLFNLSMPQLIQRLRWIGWGHTSTINNNNNNTSNDIQVVDHNNYNRNKVTHELRAVDCSTFDDDDNFANNIIVSRMNQSLWKPQTSDKSDDDLQMALALSRSLHTSQKRKAIKDLNASNIWSVEESKQKAYEKLDLILFPDNQSELIQQERERSIGSMGLSSIKTIEKNVRNISYWKLPSIGNQDNNSIFVSNFIHQIRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCL1</accession>
    <name>A0A367JCL1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HIS2</name>
        <name evidence="10" type="ORF">CU097_007790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="PJQL01001610">
        <property type="protein sequence ID" value="RCH87673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCL1"/>
    <dbReference type="STRING" id="86630.A0A367JCL1"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="35247" checksum="2D88C17349C342D1" modified="2018-11-07" version="1">MPYSFHSHSGQFCHHGHGLLEDVVKEAIRKKFRVYGLTEHMPRYAESELYPEEIEANCTPETLKQTFKDFYVEAKRLRDLYKDQISLLIGVEIEYIHHDYCNYVARLKDEVDYVVGSLHHVNTVPIDFSPELYQKALTEVNGNLVDLFVRYFDEQWAMLQAVQPQVVGHFDLIRIFADPSLADQVLLTPTVWERIVRNVDFIIGYGGLFEINSRSWKKKLTDAYPQRDIIKLIKQKGGKFTLSDDCHGPKDVGLFYEKIPQYLIENGIDTIYYLSKEGKDIVVKEHKDVVKDEFWNYLSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCP1</accession>
    <name>A0A367JCP1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001605">
        <property type="protein sequence ID" value="RCH87704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCP1"/>
    <dbReference type="STRING" id="86630.A0A367JCP1"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="67" mass="8018" checksum="4D89F02DC6C8AD0B" modified="2018-11-07" version="1" fragment="single">MEEDKLILSYHDVVIRQSDLKTLEPGQWLNDTMLSFHMEFLERTFVPKEANYLFLRPGMVQLITFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCP2</accession>
    <name>A0A367JCP2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001609">
        <property type="protein sequence ID" value="RCH87676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCP2"/>
    <dbReference type="STRING" id="86630.A0A367JCP2"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028255">
        <property type="entry name" value="CENP-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="7">
        <location>
            <begin position="278"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="383" mass="44577" checksum="AEA26BB8726B65D7" modified="2018-11-07" version="1">MLPRDQYIPIPEEDIDDNEDNNLIEHTFPPLSTKRNQGLNERKDDFVQRYRKRIAELNQNAPSLQQQEIGKPLGIDFRKKRNRHLDDSASVLSEMTIRTNTNYSAFDRLWQDDTMSVATQALLPREEEIMSPFFDKISHKSSPERFIEEFPALSPKLSQEEIKPEPYDQVEQEIQKEPMREEEMNKVAETIETNAFQDDFMDDVDFGYAGIQDEIFETEDIKAMEAEPLDELSVSTVRRRTTTRINPEHSFARRKIFDTASINIPAKDDAIRRQHVKKIFTNKIANNKRVPCNVSTFAMITDLFCDQLVDDLQAYKQNSPEGSDEITAEDMILLMRRQRMLSDKASLESLIYKHLPREYWDDLIVSALADNVLSTERFGLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDM0</accession>
    <name>A0A367JDM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="14">CPR</shortName>
            <shortName evidence="14">P450R</shortName>
            <ecNumber evidence="14 15">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NCP1_2</name>
        <name evidence="18" type="ORF">CU097_005788</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="14">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion outer membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="14 15"/>
    <dbReference type="EMBL" id="PJQL01001545">
        <property type="protein sequence ID" value="RCH88017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDM0"/>
    <dbReference type="STRING" id="86630.A0A367JDM0"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0274">FAD</keyword>
    <keyword evidence="1 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 14" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0521">NADP</keyword>
    <keyword evidence="9 14 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="72"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="281"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="463"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="481"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="499"/>
            <end position="502"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="631"/>
            <end position="632"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="637"/>
            <end position="641"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="673"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH88017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="712" mass="80724" checksum="EF8089B29E60C161" modified="2018-11-07" version="1">MTRNNSHLLDTVDLILLGTIGLGTVAWFARHQITNRLFKSSSNDAQKPETKQEAPKKERNFVKVMQQQGRRVIFFYGSQTGTAEDFASRLAKECTQKYGVSSMTADIEQFDLSYLDSVPEDCLVFFVMATYGEGEPTDNAVDFWELLSDEAPTFSQDEGDEQPLKNLRYVAFGLGNKTYEHYNEVIRKVDQRLLQLGAKRIGQRGEGDDDGTLEEDFLAWQEEMWPAFCEALGVDESNASSGPRQETFKVEELSVYDQAKVYLGEIGEWLKEGSTAIYDAKRPYSAPITSKDLFKGGDRHCLHIEIDISGTNLSYQTGDHVAIWPTNNEVEVKRLATLLGLQDKLDTVIHVEALDPAASKKHPFPVPTTYRAVFRHYLDICAAVPRQVLMSLIEYAPTEQSKEALRKLATDKDEYRIRVGDVTRNLGEVLQMLAEQESLPLEGAFSSVPFDLVIESISRLQPRYYSISSSSKESPKTIAVTAVTLQYTPEHGSPRTVYGVNTNYLWRLHEAINGLTPDTGIPEYFLPGPRDSLFSHDTKVARVPVHVRRSQFKLPRNPTVPVIMVGPGTGVAPFRGFVRERVLQKKENKPVGPTILFFGCRNRAEDFLYQEEWPELFEVLGEPSRLITAFSRETEKKVYVQHRLMEHGQEMWTLLEKGAYIYVCGDAKNMARDVNQTFVRFAQEFGGMNETKALDYVKNLRSTGRYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDU8</accession>
    <name>A0A367JDU8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CU097_010178</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="PJQL01001530">
        <property type="protein sequence ID" value="RCH88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDU8"/>
    <dbReference type="STRING" id="86630.A0A367JDU8"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016759803" description="chitin deacetylase" evidence="22">
        <location>
            <begin position="22"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="23">
        <location>
            <begin position="173"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCH88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="454" mass="49553" checksum="FF9938D630546909" modified="2018-11-07" version="1">MYFKTSALAIAILHVVGLAEAAKSSESKSSSHSKSNSTLSKPQDYWKNFKSLVDPNNITIPAIAQTTSLNPSDECKYYEPPSNFVYNAKEWPNLWETATSNGMTKTAEFQALYKSIDWTKAPKIAVRKKTSDGGVDMKGYPDSDPDCWWSSSTCTKPKHKDVNEDIYACPEPETWGLTYDDGPNCSHNAFYDYLEQNKIKASMFYIGSNVVNWPYGAQRGVKAGHHIADHTWSHQLMTTLTNEEVLAELYYTQKAIKMVTGVTPLHWRPAFGDVDDRVRWIATQLNLTTILWNLDTDDWAAGSSKTVDEVKATYDAYVQMGSNGTFAKNGQIVLTHEIDNTTMSLALEYLPKITAAYKNVLDVATCMNITYPYQEHTVSFAPFGSSANTSNTSASSDAAPAAAPAASSAATADAPGTTTISLAANKAEVPVSAGIQINPNSLIVAAFAAAAYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE98</accession>
    <name>A0A367JE98_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001501">
        <property type="protein sequence ID" value="RCH88254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE98"/>
    <dbReference type="STRING" id="86630.A0A367JE98"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="328" mass="37091" checksum="6C58BBBAB4A80CA0" modified="2018-11-07" version="1">MWSSINYNTSFEMINHQLNDLNFINTTSDNNAYHQDYIPPLIAPLVPSMPQNSLPQVNRASQRLSLEIQPCISVTEPTPITGPSLDAVDQFIAQHSADMIIEQQQQQQQPQIQSQGFLEGLLGNPGQQEAEWLSWTPNIMLSPATSVNTLDDFDVSSFHSLDLLNQVVIPSSPSFEDHLTVKDMTASTKKNRRLSEPPTPTHNFASESNSSVRRTQSEKRSRSNSASHGSFPCLHPGCGKVFNRPYNLTSHMRTHTSEKPYACSQCGRKFARQHDRNRHEKLHWGIKPFACQFCNKAFARMDALNRHLRVENGCGSHMIKFEQHQQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFJ0</accession>
    <name>A0A367JFJ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ISU1_2</name>
        <name evidence="10" type="ORF">CU097_009956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001430">
        <property type="protein sequence ID" value="RCH88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFJ0"/>
    <dbReference type="STRING" id="86630.A0A367JFJ0"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="156" mass="17233" checksum="8C3B24C266DB45EC" modified="2018-11-07" version="1">MLRNTLTTITKSTRLIQKPLSISGTRFYHEKVIDHYERPRNVGSFPKTDTDVGTGLVGAPACGDVMKLQIKVDDATGKIVDVRFKTFGCGSAIASSSFMTERVRGLTLEQASQIKNTEIAKELCLPPVKLHCSMLAEDAIKSAINDYKKKRSTQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFW7</accession>
    <name>A0A367JFW7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BCP1_1</name>
        <name evidence="4" type="ORF">CU097_011159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001394">
        <property type="protein sequence ID" value="RCH88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFW7"/>
    <dbReference type="STRING" id="86630.A0A367JFW7"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="34764" checksum="9DA6586640FA9D16" modified="2018-11-07" version="1">MNSLKRRAPIDEQEDEKPLKRSHKQTEEEEEQDSDDGLQEVVDVDFDFYNPDEIDFHALKKLLTQLFSSDAELINLSDLADILIEENHVGTTVKVDDQKSDPYAILSVINLQQQKDKEGIQQLCSYLLNKCPKKNGPLHQAVSEILNHKQVGWVVSERFINMPVEIMPPMYAMLQEETKKAVQQNEPYSFEWYMFISKTYREVASSIDDEEEEGEKAGSSKKPVNNETFYFQSEDEIIANYAEYQFDYTFTNSEKEQAADSRRAFSDFGIQPARRLLFVHQSKFDDLVAEISKTCSSTVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG99</accession>
    <name>A0A367JG99_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001371">
        <property type="protein sequence ID" value="RCH88973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG99"/>
    <dbReference type="STRING" id="86630.A0A367JG99"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="358" mass="40515" checksum="488BB1419584988F" modified="2018-11-07" version="1">MPYYQQQGYQTPYQNTVLNNAPILTHPNGLSPMQHAGIPDQMTAPPAAHPPKRKQVKNACTNCQKACKKCDDARPCPRCIKYGIADTCVNSVRKERKKGIKRGPYKRRQKTEDKSRKTDGSDPNAQATQYAPTAIRGAAFPLAYPSNLNQYGQPYDPYSQYAAYHKEQMMSQPYVVNPVYPPIGYPVLVATNSDQQQQHQQQQSSQQPNASPSNQQQTQQQQQPSQQQQQHPYPYMLHQQPSPQVARPPLMQHNEHYPSQMYYQQQPPQQQHQAQQQQQAQQQQQQQHQQQQQQQPAQTHSQPASQRNSPHLPDIKADPSQNQDGFGKQSMTTPMPSTSTSTATTSSPDSASWVPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHA8</accession>
    <name>A0A367JHA8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001313">
        <property type="protein sequence ID" value="RCH89307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHA8"/>
    <dbReference type="STRING" id="86630.A0A367JHA8"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="365" mass="42349" checksum="5E04E5B3BC0148CD" modified="2018-11-07" version="1">MISFYAEELSNINIVRATILAEPGYDVAKQLQVVDNQLILDSETKIDLSTVDLSISSQDWIVSRVDQPTDGLVPWEVKLSQCRQAQQPRSQQTEVKEWWSTSVLRELSEFKCKVCAQSLFLKDKEYKLKDLPSEHWYELVECWICHETKPEEHQARMRPILARPTVLLVGSTYFLLHPDDMIANSIQMDKVVADRLNVSTYKTKDFKKVGDAIDIIVLADTKIQDKLHDNYKQFVGMKNRPTNYYRWERGTMTKWSAINCSHCQQAVGEGQYCIENDQIQLLAVKLFKYSISILPNLQEQPGFIDFFVSDLISTAKIHATHKFLIQGRQSTRHFALIWLFNWDTSIIYNNNKETLKKERGNYSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJC2</accession>
    <name>A0A367JJC2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HSP90_3</name>
        <name evidence="10" type="ORF">CU097_009335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001187">
        <property type="protein sequence ID" value="RCH90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJC2"/>
    <dbReference type="STRING" id="86630.A0A367JJC2"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="700" mass="80407" checksum="264FEE3E133EC6BC" modified="2018-11-07" version="1">MVAETETFSFQAEISQLMSLIINTFYSNKEIFLRELISNASDALDKIRYQSLTDPSVLDSEKELYIRIIPDKKNNILSIRDTGIGMTKADLVNNLGTIAKSGTKAFMEALSSGADISMIGQFGVGFYSAYLVADKVQVITKHNDDEQYIWESAAGGSFTITRDEVNPPLGRGTEMRLFLKEDQLEYLEERRIKDIVKKHSEFISYPIQLVVEKEVEKEVSDDEEEVVSEEGAKIEEVKDEEDKKDEKKKKTVKETVTEKEELNKTKPLWTRNPEDVKSEEYAEFYKALTNDWEDHLAVKHFSVEGQLEFRAILFVPRRAPFDMFETKKKRNNIKLYVRRVFIMDDCEELIPEWLSFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLEMFQEIAEDKEQFDKFYEAFSKNIKLGIHEDSQNRAKLADLLRYYSTKSGDEMTSLKDYVTRMPEKQKNIYYITGESRTAVEHSPFLEGFKKKNIEVLLMTDPIDEYSTTQLREYDGKKLVCITKEGAELLEEDEEEKKKREEEKKEYEGLCKTVKEILGDKVEKVVLSQILTDSPCVLTTGQFGWSANMERIMKAQALRDSTMSSYMASKKNLELNPNHAIIKALKAKAAADSNDRTVKDLVSLLYETSLLTSGFSLDDPSSFATRINRMIALGLSIDEEDTPIEEASKEEAPEENNEASKMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJY4</accession>
    <name>A0A367JJY4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001152">
        <property type="protein sequence ID" value="RCH90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJY4"/>
    <dbReference type="STRING" id="86630.A0A367JJY4"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15852" checksum="098F8F90577A544F" modified="2018-11-07" version="1">MLPPPNQDLESLCYLETMFQEYGFDDGFRDGEQSGELEGRIFGCEKAFDLGKEIGFYAGCVDMWTQLSIDHPDMISSKVLKQLESLQKLIDQFPDYNDHDVDLLALRDKMKNKLRVISSLLGVQQRYLNEEKPKMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKA9</accession>
    <name>A0A367JKA9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ACOX3_2</name>
        <name evidence="18" type="ORF">CU097_008638</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001131">
        <property type="protein sequence ID" value="RCH90380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKA9"/>
    <dbReference type="STRING" id="86630.A0A367JKA9"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="284"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="491"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH90380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="680" mass="77079" checksum="D01F5E0DE4A963F3" modified="2018-11-07" version="1">MSIQAPKDMERERQSASFSIEALSYFWMGGKEKYIQRQAAYDYIKYDPELVVQPPRNILDFTKEEWREFTMGQIYRLVQLKEELKDNQGLFKEIVEASFNYSESLCMRNGVHETLFRSVVEMMGNNYQRTYWGKLLNDYKVIGCFAMTELGHSSALRGIETTATFDIETDEFVINSPTITSTKWWIGLAGQTATHTAVLAQTIIHGKNVGANWFIVPLRDSVSGEQFSNIRVGDIGTKVGHQGTDNGWIQFHKARVSRKNMMSKWARIDRHGTYQPAPNPAVMYATLIPERLGLVDVSTTLISQALTIAVRYGVVRRQGSKNEQIMDYQSHYAKLIPAISFMYMVKNSLSTIYQQFGILTASGKIEQKLYLDHMGDMHCMSASLKGLSGSLSASILEVCRRCCGGHTYSAYNALGHLTADWNVMTVGGGDDTVLLQQASTYLLHRLNQKIKYNAYPEFKYESSTSYFTYAEELLAAKTWHVKEVDDCLKDLSLIQEALHVILAKRLFSIQQALENGATHNDVLLDANRVAELHCAAFLYSDNARRFSAINNSSLDTSVAIIMRQMTVLWGLYVLRTYGDQGFLEGYISPQQLKDIEKAYLKLCKVLRKDVVGLTDAFGLPDFVLKAPIARYDGNIYQSYFDTILQAPNNTGVPPYHGKYIRPLTEKFSQIPLEKTRNKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNJ6</accession>
    <name>A0A367JNJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_012841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000957">
        <property type="protein sequence ID" value="RCH91530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNJ6"/>
    <dbReference type="STRING" id="86630.A0A367JNJ6"/>
    <dbReference type="OrthoDB" id="2266445at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003:SF0">
        <property type="entry name" value="GLYCOLATE PERMEASE GLCA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="L-LACTATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29938" checksum="FC5F7D5179006502" modified="2018-11-07" version="1" fragment="single">MSAIIPSPPPVNETVGLFVQELTPIGNSLVGSFFVGLIPLLLVLVLLGIFKVPAHYSSASGLVVCIFIAIFAWHMPAQKAFESIGNGIVFANWPIMWIVVNAMFIYNTAVYSGIFEYFRRWMLTYTPPDKRIILLIVGYSFGALLEGVAGFGTPGAICSSLMVSLGFDPLDALTYTLIFDTTPVAFGALGIPVTTLAAITGLPVMKLSAMMGRQLPLLSLFLPSYALIFYAGFRAGFLECWPAALVAGLSFAAIFANLVGPELPDLIAGLVSLISLIAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNR9</accession>
    <name>A0A367JNR9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000951">
        <property type="protein sequence ID" value="RCH91568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNR9"/>
    <dbReference type="STRING" id="86630.A0A367JNR9"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="1">
        <location>
            <begin position="256"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="424" mass="48705" checksum="E3D1E595FD819357" modified="2018-11-07" version="1">MNSTQSQASTNPKPVLHGVRIKQRKGVQKANAKHEPEIFRENILGQLNTIKKGDFEAISSKLDSLGNTLDYRKYGDSLFEILITGGIIEAGGIINDDSERSSFCIFAAEDDAAVIKKYVEVFSKLIRRYKYLQRILGETLHNLLQYINKWKPEENSKLAKSTSLFICNQLVPTSVLKVLFKDYLVKEGHSLDFTTTVFRTIMEEQSVEQLGRYLSSEDLDAHVIEFFPPNKRDEDCLVRHYEAEEMKGFVDYYLKNKKNSKKGSLLNELHEQLMNDATETAVINFIKSSMKEAGLNEAEVVPIIWQSIISTLDTMNARPDQLESQVLRAINRWSKVLEAFSTSPKTEIVLLQKAQLSCYEDVKLNKYFRKIVQTLYKNDVLSDNAILYWNDKAHLVQGKTLFLKQMEPFVTWLKENDEDSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNY8</accession>
    <name>A0A367JNY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EMC2_2</name>
        <name evidence="5" type="ORF">CU097_009138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000936">
        <property type="protein sequence ID" value="RCH91680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNY8"/>
    <dbReference type="STRING" id="86630.A0A367JNY8"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="4">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="242" mass="28584" checksum="373CE9BB52C00100" modified="2018-11-07" version="1">MTRFNHAEAINELQELRTTNERCCERVVSLAQRIIDDNYTSTLGDQVWPFYEQAAIAALDTQNFTLANYCIDKLKHRFTEKSLRFRRLLGMRYEAQGLLDEAQEVYDSILKEDETNLLASKRQIALLKARRKDYELMEALTAYLDTYYDDCEAWLELCEAYASKYMYEQAAFCCQEMILLQPSNHIFYLKYAEICYTMNQYEMALKYYCKVLELCTDHVRALYGLHLVSSQKKNANLLLNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPZ6</accession>
    <name>A0A367JPZ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Golgi apparatus membrane protein tvp18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TVP18_2</name>
        <name evidence="2" type="ORF">CU097_011975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000900">
        <property type="protein sequence ID" value="RCH91939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPZ6"/>
    <dbReference type="STRING" id="86630.A0A367JPZ6"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="113" mass="11871" checksum="8323392D70D23E63" modified="2018-11-07" version="1">MKLSLETFRFTDNVLIVLGIVGFLGHVIFSIVGFVIAFILVFVEVPLCLKFCPTSPKLFAVVMFLSNLKGTGPLIATGVSLLLAAICYGIAAFTGQAFASSKLLGGTGVDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR64</accession>
    <name>A0A367JR64_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000838">
        <property type="protein sequence ID" value="RCH92375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR64"/>
    <dbReference type="STRING" id="86630.A0A367JR64"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38545" checksum="19596E46FFA7F39C" modified="2018-11-07" version="1">MAILSENRRRSISGASALLTRRFTQQTTTNNSKSDIVRRRATIAIKPPKVHVRIVPSIDNPGRSLIFDIVDRNLEYGTIIKIGRYSERNPNNSDCMSFKSKVVSRCHCEIFVEQDGKLYIRDTKSSSGTFLNHIRLSPAGQESQSVEIHDGDLVQLGVDYQGGREEIYRSVRMKFEINRHHRPRPVSFSLATFQNLRSLTTSSSTDLDECCICLYSLAPFQALFVAPCSHTFHFKCIRPLFQSYPGFQCPMCRTYSDLEASVDHHAIEENDSHDTIHHQNNNNNDDEFNLQSSPIFIQSDDAVPLETTNINRISTAVMDSPSLQGKLYILLLPSLSDLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRQ9</accession>
    <name>A0A367JRQ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000813">
        <property type="protein sequence ID" value="RCH92539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRQ9"/>
    <dbReference type="STRING" id="86630.A0A367JRQ9"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="152" mass="17138" checksum="BA61E2DDABBFFE0C" modified="2018-11-07" version="1">MSKEQQPRLELVDPKNQVLQVPEFPARNGPQRLIAAATKQPRGREKVMLEPGHSPLDWANLKASGKDLRGVPELCRVTLDELKKHKSPEDAWTAIQGKVYNITPYLKFHPGGVKDLMRVAGRDGTRLFMLTHSWVNTDYLLDKCLVGFLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTL8</accession>
    <name>A0A367JTL8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_012613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000720">
        <property type="protein sequence ID" value="RCH93256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTL8"/>
    <dbReference type="STRING" id="86630.A0A367JTL8"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="95"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="18989" checksum="D81CE1E542A16614" modified="2018-11-07" version="1">MSYISQLNLLDDSPSLIPEEQLREELALWANAQFTFDMQPGSEAAIEKPRTSYELYAPIAPAPTVTNNKVINTTVVVPTKTTKKQQPKRTAKELDAIEEDKRKRNTAASARFRLKKKLKEQALEQTAKEMTLKAKQLEERVQELEREAKWLRALVLEKDPSLLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTZ9</accession>
    <name>A0A367JTZ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000696">
        <property type="protein sequence ID" value="RCH93452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTZ9"/>
    <dbReference type="OrthoDB" id="5545891at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="23416" checksum="454C14D3BB338749" modified="2018-11-07" version="1">MTSLLHGPCSSCNVFLLWNPPWLQVLCSRQTLNVTIRAPGSDFIPSESMVEQCPYIQKGFFKRPLPETDRRRFLFECPKNSLRNYDPPKLNKVCLSSTAKQHYTQLYNIQYRLSGITRPLDWYTYQLLHGNWDLPILQQQSLDMVLAIHELLSDLASHITTRRTDSMSRGISNQFDAPSIDSNYLLDPKEMVDHVKLQQTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUN3</accession>
    <name>A0A367JUN3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000682">
        <property type="protein sequence ID" value="RCH93559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUN3"/>
    <dbReference type="STRING" id="86630.A0A367JUN3"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="62163" checksum="C0381C956313AA47" modified="2018-11-07" version="1" fragment="single">MILYRIIGNDLPPRHKEGQTLSNLQFILDHEPTFPNTRKIFVLNRIIDPVNEATIIRLLDRYNMEYIRVPFDEKEYEQLDFQLESFPDADFLHSDDYRRYSKVAKLRALDYTYHKKNLYAMNNNGGRNTAIQHGKSIPNAKWIMPFDGNCYLSNNGFKEIKTQLEKYGKDTKYFVVPMTRLLNNSVLLNNLDERPKTPEEPQIIFRYDASEEYNLNMRYGRRSKLELLWRLGALENRRLNRPTVPWEPAERPYSKDKGNFKNIGWVFRLFSGNPQQEENKKEASSIRAFNRLLAIQSSLDSLDESIARRTFRHDKLFLYNEIDVNQRRYDYWTKHKEVTLAVERLEQVANEVLEGSQQRLAPISSTTQDGMPFETVPEKDELGPLSQNVTILTLAQYLLGNEKYGRGAANLIRVHFLNEYAVEDEDEYNSARRIPDDSHLLDFLSDQGYSFPSLSRVPHVVPKYSNSRVLNTSDLTKTDLSSLLDCIRLLRKMQVLTHKEYIDLQAITAEFLEYLVTSPTGIHLAQMTDHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVL3</accession>
    <name>A0A367JVL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endoplasmic reticulum membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000633">
        <property type="protein sequence ID" value="RCH93976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVL3"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22293" checksum="628F7156F3D91272" modified="2018-11-07" version="1">MSDIFSLKKQLIVYGAHHNNKVNVAIHMVFVPTILWTALVFFSNTGPLIKTNPIFNVFEPNFAFFFIASYIVYYVILDPIAATLYTPILLYMCHSATNYYKTNPNANKIAIVIHIISWILQLLGHGLAEKRSPKFLDNVVQAFVSAPYFVFFEVLFMLGYRPKLYKEVMYEVNKDIATFRARQKRRDVPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVP0</accession>
    <name>A0A367JVP0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleolar complex protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NOP14_2</name>
        <name evidence="9" type="ORF">CU097_002993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000630">
        <property type="protein sequence ID" value="RCH94000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVP0"/>
    <dbReference type="STRING" id="86630.A0A367JVP0"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="920" mass="105521" checksum="599E6EE4494A6435" modified="2018-11-07" version="1">MVSSKSKEGSGGSALKRLKKSLVAAGVVGPQSKSNRSKKDRKKGKPVTDKIDVDKKLAHIRGEFNPFESKVQRQKFEILGRKLKGTQGKPALSKQIGEENRKKTLLLEMKNKNRHGGIIDKRFGESNPHLTPEEKMLERFTREKQKTARTSMFNLEDDEDISLTHYGQSLSTMDDFDDAGLGLSDEDESGQMDKNVVSKLHFGGFGDEEEEPEHKHKSKHEVMKEIIAKSKMYKAERQAAKAEDEELRETLDDELKDIRGLLETKPARKPLPSQTSLFKKVEGEDNNKDLGDYSDYDTALLELATDRRAMATDRTKTEEEIALEEKEKLEKAERARKRRMEGLDSEDEEEVDKKGRKKRKNVPQGDDLEDDYLEELEDEVDRLGKGLTLEGIQNGEMDEDEDEDEEDEDEEAEEAEEDEEDEEGEDEDEEEEETDNEDIEGSDDEAPDFGDDDGDDMNEFGQTGAIKKKPSVQSNKQSTANEKREIPYTFECPESHDAFLSILEGLDVQDVLVVTQRIRVLYHVKLHPENKQKLSAFLGVLVDHVAYLASTVSPLPREVLEKLSVHIFELSQQVPEAATDLFTDKLRKMQAEMGKKIKFDNGSSWPDVEDLIYLRTIGQIFSTSDLQHPIGTPAALFMCHALAQCKVQTEVDVGRGLFLTQILYEYQKVSKRYVPEVLNFLSKNLVMLAPKDTFASDFPGLFPLDKLGQMPIKNIKGNDIEHIPNVTLDELSTETESDDHYRLSLVQATLRQLEKYLQLYASTAAFKEVFEGTLDVIERLNSLEWHKDIKNLLDTLKGRLERQIKFCIEKRTKTPLRLQQHRPIPIAQHLPKFEKAYSMDRHYDPDQARSQLRKLESQVKKEKKGAMRELRKDNQFIAREKVKERKAKDEEYNKMINSVMHILEGEQSEKKQLEREKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW41</accession>
    <name>A0A367JW41_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000620">
        <property type="protein sequence ID" value="RCH94079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW41"/>
    <dbReference type="STRING" id="86630.A0A367JW41"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017043291" evidence="5">
        <location>
            <begin position="21"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="558" mass="63518" checksum="340638EBC0BE1362" modified="2018-11-07" version="1">MKLSTLILALFTVASQLIIGTPQETFDLIANFREPKNILFACNIGGSSHIVWVLEILEELAARGHHVSFYTREDQAKFIKNFPSVELILNGPALFQPEEARALLERLVAMEVVKGILEKEQLILMNIKEEYYKFRKTIDQNKIDVVLCDYLNMACVEAAKSAKIPNIITVTMVMGPDVSAPYINTDFFNVHRPISKGVPFHERLIDRVINPLRYYIGAQFFASQLTQEQISVGIEPKLSVLERWEDSMKIVNSVFGFEFPRPMGPLVELIGPIVPRTYPTLNDELQAFLDHRRKVVYVAFGQLTVPTPSEIKFILTALLENMETKYIDGIIWSTRGIREHFPDIIITRTNTTYDINSFFTNPADDSNIAFVNWAPQVAILHHPSTCLFLTHGGAGSLYESMHAGVPIAVFPYFSDQPATAISAEEHGTGRWLKRTLSQDQATDLIKEIVDDTAGKYRRNVDRFKALVQIRNAHGKQRGADLVEEAIFTHVNGKLKHRRDIRRDLSFFKAYNLDIYSFVLIFLATFAYGVYRFVFVLYRMAFNAVSTPRMALDKELKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWQ3</accession>
    <name>A0A367JWQ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000620">
        <property type="protein sequence ID" value="RCH94081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWQ3"/>
    <dbReference type="OrthoDB" id="2385582at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="21381" checksum="774D548184A7135D" modified="2018-11-07" version="1">MYAWRFVDCAFDNVPEAEAVRGEPSSLASAARKNKDRVIQDRKRIGRKCDIIIRSVDCNHSASKEYGVGETGSIVDLDGAKMLKESRIKLSKVMRDMFNSLQSGIDHAKLGDLQIVDYLHYGLSCSLLLINSPACSYVTRLSRYPTMNQGGSAHALEISKDVSGFGATFLSALVMAWKAKEVVKAMVELLAHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX54</accession>
    <name>A0A367JX54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000563">
        <property type="protein sequence ID" value="RCH94572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX54"/>
    <dbReference type="STRING" id="86630.A0A367JX54"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="53"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="254" mass="29962" checksum="D27722EF062C7915" modified="2018-11-07" version="1">MSNLGFLKFCTTPNYSKHPFLKSVVSKLPFSYPESQQNWESALKDLIVPSIVVQLDVGGYRYTTLYHTLMVSRYFEKVLKRILERPEAWANADWLLVNQDGKLFGYILDYLRTANASSLPSDLNILTRLKEEVRFYKIPFMDSIINEKIRILNSPQEEARERMYKILYTEEYDRMKRTKGFKNNDGQLVSDILLEYEEIAKLSIQEPYWVCSRGIRIHTSPTKCGRMCKREFEPDHHGWHFIQVEKTVLATRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY04</accession>
    <name>A0A367JY04_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_011087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000537">
        <property type="protein sequence ID" value="RCH94810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JY04"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="537"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="686"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="833"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="979"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1128"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1622"/>
            <end position="1642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1678" mass="191817" checksum="EF2EA862196D3F9E" modified="2018-11-07" version="1">MSESLPIKFTEQAQLQALGVNAAAIGFTTLTMESERFICVKEVVNGQNQVVIIDLTTNEVNRRPISADSVIMHPKVKVMALKAQRQIQVFNLELKSKLKSYALNEDIVFWKWLDAKTIGIVTELNVYRWSIDGDSIPTKIFDRHASLSGCQIINLRASSDEKWYVLVGISQRDNRVVGSMQLYSKERGVSQPIEGHAAAFAELHLPEAVKPIKLFTFAVRSFNGVAKLQIIEVDHQEGNPPFQKKAVEVYFPPEAQNDFPVGMQISHKYGIIFLVTKLGYIHLYDLESGTCIFMNRISSETIFVSAEHGPSSGIITVNKKGQVLTVSVDENSIVPYILNNLNNTELAFKLASRGGFPGADDLYVARFNQLFATGNFGEAAKIAATSPRGILRTTETIEKFRQIPAQPNQLSPILQYFGTLLEKGTLNKYESLELAKPILTQNRKPLLEKWLKEDKLQCSEELGDFVKQYDTLLALSVYLRAEVPGKVVLCMAENRQYDKILAYAKTVGYTPDYASLLYNIARTEPEKAAEFATALVNDENGPLIDPSKVVDVFQSQNMIQQATSFLLDYLKPNREEDAALQTRVLEMNLIHAPQVADAILGTNMLTHYDRVVIGNLCEKAGLYQRALEHYTDIHDIKRIIPYTHVMNAEWLVNYFGNLSVDQTLDCLKEMLTNNLRQNLQIVVQVAIKYSELLQPHNLIDIFEAFKSNDGLYYYLGSIVNVSQDPLVHYKYIVAACRTGNIREAERICRESNYYDPEKVKNFLKEAKLSDQLPLIIVCDRFNFIHDLVLYLYHNNLQNFIETYVQRVNPSRTPEVIGGLLDVGCDEDVIKNLLLSVQGDLPVDKLCEEVEQRNRLKLLLPWLNLRVTAGSTDPEVYNALAKIYIDTNNNPEPFLKENEFYNPRVIGKYCEKRDPYLAYICYEKGQCDYELIHITTENSMFKHQARYLVHRRDQALWSSVLVETNEHRRELIDQIVATALPECTDPDDVSNTVKAFMSADLPNELIELLEKIVLEGSAFNDNKTLQNLLIFTAVKADPSRVSEYISRLDNFDASDVAEVCIGEGLYEEAFAIYKKYKVDANAVDVLIEKIGDLDRAFEFAERSDKPDVWSKLAKAQLDQMHVKDAIDAYIRANDTTNYMEVTRCAAMDNKYEDLVRYLQLARKHSREPFIETELLFAFAKTDRLIDLEDFLASPNIAQIQEVGDRCFRSGMFEAAKILYSSISNHASLAQTLVHLKDYQGAVDCARKANSTKVWKEVNAECIKQREFRLAQICGLHIVVHAEELDELVKTYEKNGYFEEIIKLLEAGLGLERAHMGMFTELAILYSKYQPDMLMEHLKLYVSRINTPKVIRACSDAHLWRELVFLYVHYDEFDNAVTAMMEHSVDAWEHSAFKEIIVKVSNLELYYKALKFYLAEHPLLLNDLLSVLVPRIKHTRVVQMFEKSDNIPLIKQYLISVQDTNNREVNTALNELYIEEEDFEALRDSIDRHDNIDTVDLAKRLEKHELLEFRRIAAHLYKRNRRWRQSIALSKEDRLFKDAMETAAESKDREVAEELLQYFIEVGKRECFAAMLYTCYDLMRPDFVMELSWRHGLTDFAMPYMINIMKEQFTKISTLDKEVNELKEKVAKQESSNENTPAPPVGMGGLGNPLMLTAGNMMPQQSPMMTGTPFTSSPNPQQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ48</accession>
    <name>A0A367JZ48_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subunit of tubulin prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GIM5_2</name>
        <name evidence="3" type="ORF">CU097_013426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000490">
        <property type="protein sequence ID" value="RCH95213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ48"/>
    <dbReference type="STRING" id="86630.A0A367JZ48"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="134" mass="15092" checksum="155E50950E3A6DB4" modified="2018-11-07" version="1">MSQQQVNITDLDLSSLQQVKTQLEEELNHLTQSYSKLKTVQGRFADCADSVNSLKTEKSEGKLSDVNKVIVDVGTGYFIEKSVSDATTFYKDKVDFVKNNLGTLEKTITDKQSTLRAIVNVMQEKIQEQAQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZJ4</accession>
    <name>A0A367JZJ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">WDR6_1</name>
        <name evidence="8" type="ORF">CU097_008147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000503">
        <property type="protein sequence ID" value="RCH95081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZJ4"/>
    <dbReference type="STRING" id="86630.A0A367JZJ4"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118726" checksum="ABAA0154E43D4DF0" modified="2018-11-07" version="1">MQANRIHLILSDSKTETRKLAIFGSKYLSILTIEVSDDNASCTVEQTFGPFKDWIMDAQWMIENDDSSIQMSIVYAHNFMEIVRLNGSGSVDVLYSVQCQVRCILYSARIFGTTRDTLTIASGTVFNEVHIWKPLIKDECDDAVVYKKLIGHEGVIFCVRFNHDASQIASVSDDRTIRIWSLEDESKQPLILFGHTARVWDCQFVGQYLVSISEDSTCRVWKNALLQEDVEDEDNENGNDCIACWEGHASKNVWSCAINPEHNVVATGGQDSGIRLWSFASIKNSRIDSEEDLNSFPLPAERGKDYVRNFAMVKDQMLIGATTEGYLLKCDKSKNVWEEIQHDSSYRNYAIMKSSKCGRVVVIGNIYGDLIVISPENKFEPVKVPAHKQKLFEIFIESSSNENILYIVSNGYNERVLFHVLDLSSSKPSLETLYNIEMPVEKTTILSIGIVEEHNILICGSRESALLIYRIPSYRASLDHAVQRLKASLQLRRSHGRQAITSVLVRPRSRTDDDEEQETNGDVDFWTTGRDGCYIQYRLCLLKEASEKMPSDAGCTEAEEQETQLGVASRGDTLVRSRDMTLEKIYRNKVTKGTLEGSLFIDNELLLLGFFRKHFFVYNEKKNFVMTSINCGGGHRRWNFFADDAKLNKSAFAFIRKEVLFAHFRDISGMDEGFNDSILQQNYHGREVRALRFLELPCKGMKEPWPLLFVTGGEDTILRIQQYMPSSTSGFHTLVNIRKHTTVIKTIDYSQGSSTLLFTSGGLEELRCWKIEVLSPRAEQEPVHLNCLEMANCPALTKDIEVRIMDITTFAISPKYHIIGAVYSDSMIRFWLFNEDSRKFSLVADGTWHAKCILQICHVQVDGHVYFFTSATEGGIAMWDIHDELQSALEKVDELEAEPTLAAFRLSEPLHYYRTHMSGVNGLEAIPYKDKKHLLVVTGGEDNAVSATVLHIQDDNTIKPIGDSFIIPDAHASSVTGIKCVGDIIFTCSTDQRLNIWKVTNNLEDGSVSLTLSAATFLDVPDPSALDAVSLNGCIHAAATGIGLQSIKYGQLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0C9</accession>
    <name>A0A367K0C9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RNA-binding protein eif1ad</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF1AD_1</name>
        <name evidence="6" type="ORF">CU097_003299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000447">
        <property type="protein sequence ID" value="RCH95630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0C9"/>
    <dbReference type="STRING" id="86630.A0A367K0C9"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="17319" checksum="1EECCDFFBF0ED0AB" modified="2018-11-07" version="1">MGRKQTIRNQIEQDIQLQEGQKYAKSLGPRGNHQHEVEFTDGTRKLVTLPPRFRNLVWLKRGHFVIVDPTAGTVSEKVGGEIVHVLYPKDIKELKAKGEWPEEFTDKKAQDEEEDEKRKDSDDDDDLFVNNNRHVMSETEEEESSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0D9</accession>
    <name>A0A367K0D9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000443">
        <property type="protein sequence ID" value="RCH95674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0D9"/>
    <dbReference type="STRING" id="86630.A0A367K0D9"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="18823" checksum="A32520E549E19FE4" modified="2018-11-07" version="1">MASARVIYTNTNSCLHSSLLGNVESVPASDINSCLDQGSFKRQVEVGRVVLVNHGADAGKLAVIIDIVDHNRALIDGPTTGVARQALSFRRMVLTPIVLKNLPRNIGQGALKKAIEKADVVAAWNKTAWAKKIEQRKIRASLSDFDRFKLRKLQNKRRFAVAPAVKAAAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K120</accession>
    <name>A0A367K120_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GLY1_4</name>
        <name evidence="7" type="ORF">CU097_013773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000421">
        <property type="protein sequence ID" value="RCH95904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K120"/>
    <dbReference type="STRING" id="86630.A0A367K120"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="41626" checksum="704258FFC8213BDB" modified="2018-11-07" version="1">MLTIATRLISKRSFMPISHRCYGNLQLKFTKHQAIDLRSDTTTQPTDAMFDIMKTASRADDVFAEDKSIHDLERYVADLLGHEEAVFCVSGSMSNQLGLRLLLTQPPHSVICDARSHIYNYECGGMSYHSQASPSPILPRNGHHLTVEDMENNLMTDPLHSPTTRVVSLENTLNGTIMPLDEIERIHQFCQSHDLKMHLDGARLWNASQATGIPLKSYGRCFDTVSVCLSKGVGAPIGSVLVGSSSTMARARHLRKLMGGGWRQAGFLAAAAHHCIQNVVPTMPETHKLARRLASSFEAMGIQITVPCETNMVFIDTSTVGVKIDLLADELFKQNVLIPKSSGYQTRLVLHYQVPSDTVDTIIKVTSELIKKQQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2U5</accession>
    <name>A0A367K2U5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_000740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000391">
        <property type="protein sequence ID" value="RCH96211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2U5"/>
    <dbReference type="STRING" id="86630.A0A367K2U5"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="10">
        <location>
            <begin position="263"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH96211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="648" mass="73863" checksum="51445795E6F03EB2" modified="2018-11-07" version="1" fragment="single">VVGSYSSMNNVPETPAGYIVNGVVVDFRVTSVEWKDQRPEPLITNWDLFGTNIRLQSKSGSIDFPVARGMSYVTALYNDLTPQFFTQHAILQVNSDMFQSNDTYTGRKFKLSFNDNPTSTFIIYALGKEPLTLQKIGNNNLVAASKYNGPIQVTKLPSKESEIVLDFNRGTWATGGDIKLDLNRNSYTIEWKQGGNRSKNLLMYAYPHHMKSFIRDGSLKKTNLKLQSSTKGTMQAVVGNVWTLIEKNVSSIDWFPSNPTPEASTRNEIMENLVSDVRLNYTEETLKGDNYFSGKGLQKLAILSLLLNKPNQTALKNQELAEESLNKIKAAFLPYLENRQMDPFRYDALYKGIVSLNGLPTELGGTGNRDAAFGHSYYNDHHYHQGYLIVTAAIIHYLDPAWNTNQIRKWTEALIQDVNCQANDNADFAQFRNWDWFAGHSWAGGIKVNGALDGRDQESVPESVNFYWGVKLWGLATKNTDLVKLANLQLAVMKRATYEYFWMLDGNENRPPAMVKNKVAGIFFEQKIDYTTYFGRFIEYIHGIQQLPMTPMLAEYMRTPRFVTEEWEQKLKDVAFTVDNPWSGVLYLNYAMINPADAYPLLRTAQMDDGQTRSYSLYLAATRPSFFRRSFSRFLKEKMKNMLSSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4I1</accession>
    <name>A0A367K4I1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SUPV3L1_1</name>
        <name evidence="13" type="ORF">CU097_007898</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000305">
        <property type="protein sequence ID" value="RCH97124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4I1"/>
    <dbReference type="STRING" id="86630.A0A367K4I1"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="305"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH97124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="663" mass="74651" checksum="E618337193DFE8B0" modified="2018-11-07" version="1">MLRIIPLRQTSCLLLRINLSASTAPLRHFHQTVPILRKGGLPRKGSIIDNAVWRILSPKRHRRIEEELDRKLKNFSKSVHFRREASCLGINTKLFREISESFVKAVAAGEIPRCTVRNLLSGYTGNDISAYLDKELLQCFLDYAKPFLPEDIVDKVNSLRKISDLRYPTEWYPLARQMQRKIILHVGPTNSGKTYQALQRLESAQSGIYCGPLRLLAHEIYDKMNTKGIPCNLVTGEEKRVVSPYAPLTSSTVEMAPLGRPMDVAVVDEIQLIADPFRGWAWTAALLGLAAKEVHLCGEESAVPLIQRICESLNEELVVNKYQRLTPYKVSNRSLEGDLSRITKGDCVVAFSRRDIFNYKNKIEAITGLKCAVAYGGLPPETRALQAKAFNDPDSGFDVLVASDAVGMGLNLNIKRIIFSTTHKFNGAEMERISFPQLKQIAGRAGRFGTAYGNGIVTSLHPRDLSYIKAAVDSPIVPLETAGLQPTVEMLELFASQMPNQPFSSIIQKIEDFASVTGDYFMCNTKDKKAIADIIEDIPLEIRDRFQFATAPVSIRSEPSMALIKTLAKKFSRQETCDLEEIVELPETPPINPEHLVDLEEKHKQIIVYMWLSVRYPEIFTTEQETAVEIKTRCEKLIDEGLKVSAANKKEHRKRSRAKYSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5Z4</accession>
    <name>A0A367K5Z4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Negative elongation factor C/D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TH1L</name>
        <name evidence="7" type="ORF">CU097_006286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000257">
        <property type="protein sequence ID" value="RCH97682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5Z4"/>
    <dbReference type="STRING" id="86630.A0A367K5Z4"/>
    <dbReference type="OrthoDB" id="511287at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="565" mass="65261" checksum="58F3652C4F29C110" modified="2018-11-07" version="1">MQQPLRISTPEEHQKALSQTDAILEQNIYNDGILEYINHGGSPLEAVNLLSESYLGIPSMCNVTAASVDSVGLDSDSILRRAIRQQLKERFDPKRCDDFFMRDESHITFAWLDILIQDSHWRQTMYELLEKHPSCAFLNFAILRMSETGYKQEVARLRTTSTFVKVYDLIFEDILKEMVTKDDVDIEGIDHDLEKVCCERQETYIYTQLLIKRLQDEFGKFSFTRLKRDLELASIRNGNRTFVELLNAHLSDAPLEISRTIATILNSSHMTPADLITLKRPYLSSNPPSVHYLCNYDLMIKLLNALYVPQHGSIIRADMVDDVTFLLACASTMNDEQSLQAQQQEITQVQFVLRELYTALAPKTSVGSITGVTKYIVNALKYPISSMGLLLWIEYMTLETSYFENYFRTTETPILHIVLDVIANRHKLQQPVVFDVIKKCIKHKYNHFAPEIQMALQRTWVDRMLYLVQLNYTTPVLKYFEKEGKELDNSIIIHFVKKLLKLTQGPYSIAFTEHLINIIGHLGENLALIKDIQKSLNDFFEQVINGPYPIDESLQQSIRAIRKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K650</accession>
    <name>A0A367K650_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000260">
        <property type="protein sequence ID" value="RCH97648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K650"/>
    <dbReference type="STRING" id="86630.A0A367K650"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="328" mass="38990" checksum="18B0575C18C5DB01" modified="2018-11-07" version="1">MHQRHYSDSKSNIAKYKRALSDQYYGRDSKHKVIRQEICRYLKENEEIYKFFVEDDQSFDSHLNNMQQDGTFGGNMELAAFAKLYKVDIKVYQPGLIYVIKGVDEGEEEEEDEEEPRQVLHIAYHDWEHYSSVRNVDGPFTGPPEIKEERVQKEEQDDEGKEEDVLDSKEKVILNACPDVSIYMIRRMLKKYKGDTDKVIDRFYELRVTEKDKDIHLKERLEIDNDGNVEHLPLPEQGEEKGEEKDEEKDTEEKDKEEIEKDKERDKETTEKEKPKKMSASERKKEAKRRQKEAKLMKERAKAARRAQREKEEEKSTNEPQTMKELCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6T4</accession>
    <name>A0A367K6T4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nudix hydrolase 15, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NUDT15</name>
        <name evidence="3" type="ORF">CU097_010142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000241">
        <property type="protein sequence ID" value="RCH97875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6T4"/>
    <dbReference type="STRING" id="86630.A0A367K6T4"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="17139" checksum="DA5BC74BF2188D57" modified="2018-11-07" version="1">MTQVPQQEVRVGVACFVVHRPSDGILRILISQRKGSHGAGTWQLPGGHMEMFESFEGCARREVLEETNLEINSIRFVTATNNIMGDKHYVTIFMYSEVSSEEIKNLRVMEPEKLQGEWKWVTLDELVTYKPLFSPLQSFIDQQDTSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K802</accession>
    <name>A0A367K802_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450-dit2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DIT2_6</name>
        <name evidence="7" type="ORF">CU097_012040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000211">
        <property type="protein sequence ID" value="RCH98259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K802"/>
    <dbReference type="STRING" id="86630.A0A367K802"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="522" mass="59475" checksum="43832C43FBE90CC8" modified="2018-11-07" version="1">MDRVVQAYNNFIKALVPVLQKRSKASYITAAIALIIAQRLYSYFRVPKHLRGFPKLSYFGIAKSFLTRESPRERAKKYVLPIIDKHDGFYISKIPFGWTLYATNPIAAKQILLKSSAFPKNHGQIDDMGENLFTEFIGKDNVALSNGDTWKRQRKVMNPAFHQSLPIKTMSNVVFSLISVIDQANGTIPVASAMQNFTLDTLGLAIFGFDFKALQGDPDEWTKTYRLVSDCLFDPVINVFSSYSFILDRIYPRRRRGVIATRKLGEKFLEIAQQKRMEIKSGVYADVPDNEKDLLTLMLEAEEKGGVWTSEDELRHNIAVLFLAGHDTTAHALSFCFYHLAKNKDIQQKLRKEVLDLLGDEPVDVVPTVEQLKDMQYLNMVIKENLRMNSPADMLFSRDVQEDITLANTLVPKGAVVSINIEALHCNPKLWHNPDQFDPERFAPGGEHEQHDGMTWLPFSNGTRQCLGMNFSLFEQRLVIAMILKKYEISIPEDSIHRDHIVSDASFNGAPKSLELTFTKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K806</accession>
    <name>A0A367K806_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_014995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000235">
        <property type="protein sequence ID" value="RCH97961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K806"/>
    <dbReference type="STRING" id="86630.A0A367K806"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794127" description="rhizopuspepsin" evidence="11">
        <location>
            <begin position="17"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="62"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH97961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="42481" checksum="289D7A5C6E6BA848" modified="2018-11-07" version="1">MKSIVFLGILASVAFAFPAGQKKQFKINVKKSKSNSDMTHSSRVVSYLVKETQTAYNHGSGYYGQIGIGTPPQYFNVVFDTGSADLWVISSNCKNAVCKSHNTSFDAQRSMTFKDETVYTQIEYGSGSVYGLLGRDNIQLGNTVTLNFTNQAIINILSLSQDFVGSPFQGIFGLGLPRIASGDYDPPLVSMVLQGILDEPLFAIYTQHSAGEIDFGGIDRSRFLGEVTYVNIIDHGYWMIQLESAQFQETVFTARKAIVDSGSTLIIMPKKDAEAYHQRIKGAFKNGDGTWSFPCKNVKSLQPLTLRTATATLYLPAETLFLTPMQTNGHTCLSGVAGQDVDTWVLGDVFLKQFYTVFDVGRRQIGFAVAKPDASMTDPDYEKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K956</accession>
    <name>A0A367K956_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000177">
        <property type="protein sequence ID" value="RCH98696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K956"/>
    <dbReference type="STRING" id="86630.A0A367K956"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="5">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22294" checksum="DE44C39938ADDA0A" modified="2018-11-07" version="1" fragment="single">MNTVIPPLKLSRPSQSFKKYKLQIVQNPIRARCCGFGEKDKRPIDPPPILKLTAEDESGKPLELKAGDAVLFLVHCQLYNENGTLDKTLVHTPWSNTSPIRKQTIRYSAHKDKPEYVRNLIGSVVSNAYHLYDENSIPGIFFIFQDLSVRIEGTYTLKFVFINLAEGDPLTMSTKVQVEMVSKPFTVYSAKKFPGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA42</accession>
    <name>A0A367KA42_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000146">
        <property type="protein sequence ID" value="RCH99113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA42"/>
    <dbReference type="OrthoDB" id="2240906at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016727403" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="16453" checksum="D7EBF705797FFF90" modified="2018-11-07" version="1">MNTRSFFIIAALCLVFIQTVLADIYSQLQFIKIVSPKNGQDIEAGKPLVVKYVMQPLIVNHVAAGRALKLNVNFHKRTGNAKEQKLAIIHKSCPVAAKENKYVTYTKKWTVPKGTKPGSYAVDFVELVQLRRGQITVKETVKVNVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAB2</accession>
    <name>A0A367KAB2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxypeptidase Y-deficient</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PEP7_2</name>
        <name evidence="2" type="ORF">CU097_015570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000141">
        <property type="protein sequence ID" value="RCH99183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAB2"/>
    <dbReference type="STRING" id="86630.A0A367KAB2"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rabenosyn Rab binding" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16870" checksum="2481A19FD2A30C8B" modified="2018-11-07" version="1" fragment="single">FHQLILALEKEKALNRTSESFLRASQIRKSLLDNFALYDTLVKSIKALPARSPCMKRLQTNICAASNIYLQQNMLPLQMLPRILKEKPERKQLKQQLETYLEQTRLVEGFIRDAEREGKYDDVKTLKASLDELHGEIENLRAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB54</accession>
    <name>A0A367KB54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000126">
        <property type="protein sequence ID" value="RCH99397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB54"/>
    <dbReference type="OrthoDB" id="2281363at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17538" checksum="5CCF5A0311BA650D" modified="2018-11-07" version="1">MKIADMLNPTSVDQLVSPPPSPQQKVNNVKQSINASGKSRSRFSNEEDAIICEGVARGLTWGQISHQLPHRKRATCFNRYRTLQGIRKSRKRYSDMGSSSMTSSTSSWLPSPPLSSNHLKHYHQQQEHQKQRHQQSPTLVAPLPLHYAYVDRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB67</accession>
    <name>A0A367KB67_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000148">
        <property type="protein sequence ID" value="RCH99081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB67"/>
    <dbReference type="OrthoDB" id="10609444at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="124" mass="13263" checksum="529D51B30AAA0913" modified="2018-11-07" version="1">MVSCMLFYIISRYIVLSVILTAVSIPVMNAGASVLKKKKTSSNLSDRSHSDARGHQSTSEPMDPSSTSTTGKMLLTNDPASDGSAVPSTAFNVSVIATIKSSERKVDDIEFEERAIISPSLSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBV8</accession>
    <name>A0A367KBV8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000103">
        <property type="protein sequence ID" value="RCH99733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBV8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="10754" checksum="DAF0CC5E84CC0F2B" modified="2018-11-07" version="1">MKSIQNLKAQQYLYSTDKRRFPRGPQANQRVGAPRYELEQSNHFEVYRRLLSIYMSIQHRQTSDAKFVEIGGLEIGAVEIKPFHTAAADIDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCF3</accession>
    <name>A0A367KCF3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000092">
        <property type="protein sequence ID" value="RCH99904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCF3"/>
    <dbReference type="STRING" id="86630.A0A367KCF3"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22769" checksum="A4A82510C6A6A84B" modified="2018-11-07" version="1">MAFFGHLATFFTFAALVLEVFTMIGNTYNRAFLHSLYFATLNIKDQFVTFGLWSYCSGTGSNVNFCSHPVPAFDWSQANGIQDVIGDMHNMDRVFLANFILYWIALGLTLIALIITVLSSFRRGPDFCAAIATFFAFVVMLAVFVIVLVISIRGINIAKGTNSDIQGSLGPATWMTLGAFVALLFSSISYCFACIFGPGRVRSQDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCU8</accession>
    <name>A0A367KCU8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000085">
        <property type="protein sequence ID" value="RCI00026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCU8"/>
    <dbReference type="STRING" id="86630.A0A367KCU8"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008264">
        <property type="entry name" value="Beta_glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF2">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00737">
        <property type="entry name" value="GLHYDRLASE16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR608264-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="225" mass="25748" checksum="17F243779D16C554" modified="2018-11-07" version="1">MQDLFFANYIIPPKHNDSYPRVFHKENVEVMNNAIQIAVTINKTNSSDISCGGFGTDKHDFLYGSFRSMMKLTHVKGTVTGMFVYHPQGEIDIEMVSALQPPEAYFAVHPGITTDGRASSLTHGEWVFNFNPSADYHEYRFDWYPNFVVFYIDGAERYRMTTNILSQPGRIMFNHWTDGNANFSQGPIKEDAYVSIKNMTFFFNSTESSLHCNSTQRACEIKDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD95</accession>
    <name>A0A367KD95_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_010915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000078">
        <property type="protein sequence ID" value="RCI00137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KD95"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="241"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="415"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="727"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1228"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1308"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1229"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1363"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1380"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1393"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1409"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1419"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1439"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1458"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1484" mass="171855" checksum="F03DC94D9FA65C4D" modified="2018-11-07" version="1">MQQPIQQQQQQQQQQLNYLRANFPQQMAFAPMGYNNYPQQARSPLAQQKQPQAPQQPQQQTSPMIMNGLLANSNPSIMYQQPMLNQMQMRPNTQQYMGTFPQQQAYMQQQAAFPQQQLSPQAMQAYQQQIQRQQQYQRQRYLLQQQQQQYQQHQNYLHQQRTFAEVNVKPKRPTRNATKKKRFYEESSEEEEEEEEFDITSDEEDAAVESDYSEQGQGRKSQSASASVDPEEPITIPLGSKAFEKILDYRRNEMTGQEELLIKYKNTSFLHVEWVPLENIENEHLGKHRVKKFLQKYHDDGNRGEDFQEHLKIDRVVDDGELEDPETGDSKIYYLVKWSGLFYDQATWETEDDVRKVDSAKLDDFLSRKQIPPYKLAPTPQRPDVTRFIQYDSSPIYRYNNTLRPYQLEGLNWLRYCYYTFRSCILADEMGLGKTVQSVALLNDIYHHVGIRGPFLIIAPLSTIPHWVRAFNAWTDLNVVDFRGSNFARNLIIETEFYYQDAEANNIPGKYKFDVLITTYEMASASAMTLKDIPWRCGVFDEAHRLKNKNSKVLEVLRTFYIDHKLLLTGTPLQNNLGELYSLLHFMAPHIYDDEKYFFSEYGNLNSAHQVEKLQALLKPIMLRRFKEDVEKTIPVKEETVIEVELTNPQKKWYRAILEKNFSFLKRGTKNNKDMPHLRNIMMQLRKCCIHPYLLEGAEEVITSECNAKGQQEQFNCLVQSSGKLVLIDKLLRKLILGNHKVLIFSQFTSCLDILADYLRGRNYAYERIDGSIPGDQRQAAIDRFSTLPIEESFVFLLCTRAGGVGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQTKPVQIYRLICANTYEKDMFDRAGMKLGLDKAVMGTHDDGNANKNAELNRQEIEDLLKKGAYGAMLNDEESAKFCEEDIDQILERRTKVIRHEGNEKGSVFSKATFSAADGDNLGVDLDDPDFWEKWAAKAQIDTSDKPDENALIIKQPRRRRQVQRFGSRPADGSYSDENDSDAAYEDESDSRPSRRGRGEQPRPWSLSEKTKYERKLMIYGYGSWDLMVTHFPRRSEKDLKAVTRALMRKALPAIGKSTEEDRKLVEDIEEILVKDSREEARKHDTIPYVGATKKQIAEYRSFLSPPEYADHIERKGRNFLLRIQMLHIIRDKIVPNDWEEAKKLEIPRVTGSPPAPWWKADEDRDLLLGILKHGYQQYLAIRNDPEFCFYGKKYDDSQTDVADDDEPKNEDSLLETEEKKPITYAPKDEDSEYEEKNEEEEAVAEEEEAGSDKNKVYVWPSKADIGMRLRRIIAAFLRERASNTRRRRPRGDGEKRQRQKPAQQRQRGTGAGRRATKKRKVEEGEADETVTEQSTEASAEQSVEPVPQQENPVEQSWSDPVESKQEPIEQDSKESLSQHSSAPSLSNIMQPQNTPVQMTEQVPEQAFENKDQIIRFDLVDPPTPLVQVSNNNLKDQSTEDASVIDAAKQDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDJ6</accession>
    <name>A0A367KDJ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WDR83</name>
        <name evidence="7" type="ORF">CU097_014471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000070">
        <property type="protein sequence ID" value="RCI00268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDJ6"/>
    <dbReference type="STRING" id="86630.A0A367KDJ6"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="296" mass="32785" checksum="3C898EFDC03549CD" modified="2018-11-07" version="1">MAPYPTRLELTLKGHKGPVNDVCYNHSGQYCLSAGRDRSIRLWNPSTGLLLHTYTGHSRDALAVTASPDNAKIASGGADRSVILWDVGSGEILRRYTAHWERVNSVGFNDQSTVLISASFDATIRLWDLRSMNLQPIQIIEDCKDSVMSVHIRDTEIIAGCADGRLRTYDIRKGELKEDYIGSPITSAKITKDGNCILVSSLDSTMRLMDKSNGKLLNEFKGHKHKEYKIESILSNKDEYAITGSEDGKIYIYDVLEAKVLSTIEAHQGVATTLDYHPENINMLSGGSDGLIHIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDS8</accession>
    <name>A0A367KDS8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,3-beta-glucanosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PGA5_3</name>
        <name evidence="6" type="ORF">CU097_015748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000067">
        <property type="protein sequence ID" value="RCI00327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDS8"/>
    <dbReference type="STRING" id="86630.A0A367KDS8"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017068031" evidence="4">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="49"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="419" mass="46290" checksum="DA1D20771ABE7F90" modified="2018-11-07" version="1">MRSAFLFYLAALVLSATVEAIHKIPLYQKRTSQSEYISAPAQLVQNGMMGAVIEVGNPSQELTLALDTSTGFSWIRGTQCVNENCLDRKAYDASRSTTVVAVGKKFTMDYGRGIAYTTLCLDTFRYAGLTVENMPFGNAYRMECFDQGFDGFLGLGRNVDLNSVQEHYAKRDIPDSGFVPNAYQQGYGMGSSQFAMYTTSSQSGFSQTTASNSTPSTGVASGGWGTISKRHTKDDTPAGYLVLGGVDTDAIQGKLYYVKAAENDGSGNWAVPVRHAKFLHNLCFKVSKHAKAVLSSSTDVIGLPNKQADEFEKHWYAVYDEPDNTYKIPCCLMDRLTSFQIQLGNITATVPPHYWSYPRETDTCCDMCRTHIGRSGSDSDYVLGFSFTNAFYTQFDIEKDRIGLAIKKHHKHDGLELQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEV1</accession>
    <name>A0A367KEV1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beach-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000045">
        <property type="protein sequence ID" value="RCI00709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KEV1"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="1804"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="1968"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1734"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1280"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1766"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1776"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="2080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2080" mass="237173" checksum="01B6210630ED8EF3" modified="2018-11-07" version="1" fragment="single">MWCFPYYRAKCPDPASVILGSRRPNGRIGLVAGHENRHLGYTEVKSFSVARNHYKINVGLARLAIFGKNVVDNNRSQDVMAIQAVGMSMIFHIIQKTADKIYPMSKLEHIRFPSSIDEMAMMLGIMDKLMDIIVTLRTHRLEASLLQAVFSKEALNGVMEAIQGIPRNDVDLRLEMLRTVQKLFKLDGSSSDIFRREGGFVSLVSMIIALEGAFEDPQRYFGDDNVTLEEATDKLILLLQTIFNILAESMHRSEMNKQYFMKDVGYRTVENAIILTGALVQRHIAERVFGILLSFVIESEAVLDIFISVTNDQDNTSGSAENEMYMEKIESMLSQSTVSLANPEIIPTILHLQKAASAHKQLCRAVLSALFTLSQASRGNQVKLNRSGLLLTLLQRLFPENETEDVEEDQDREIMLSLMKNLMNMGISSNELRYIFKRFDLNTENNQSSDMLDLILHGASGSRWPGFIQFNDPTMYLEIPQLANFPPPNPGYTLLFWLHIEKQNDVSSLPLFNVWSDQQQIFRVFIDARSKMLLVQSSYSKQPVLFKSFEFHVGFWYHLALVHNKSRLSPRLSSISMYDTLEKETINLYFSLGPRYRSLYQDSLRQFQTYEATTSLYLTIRNMSKGRRSDSSDQQLLTSILDGSAFQVVPENKIVFAFSAYNTLSEGAHSGLTLTGMSLATRQTIIAENNNSRMIINAAVPKLDIAVYRPNSMGYLIGELIVAYPLGLDESICKIGGCAVALKLIECSQTAQNLCKATAFLFETIRYSWRNSADMERCHGYEILAYILKQKRDIITLELFELLLVFIGKNAQQPENSIINNPLIYRYVVLNFEIWKKTSLEVQKAQLDQFNLFLSTSSFRAFNVKRLQKIHLVKKLLLAFRMSIYSKELVPYVVKALKAVMLSNWDTEGIRAIATFLASTVSQGSISTTKSNRLRSDSTHSTSSSVTIDEDIPATTDILLDARQAGRFKKSAQMCNIVLEMLHDILCDKSIDPEYINRFASTITNRWPLLFFAPNTNPFTALLAIRVLARLFISQGPSYVGKFKSASDGFLILRKLLPAYWNVAQIHETLILLMMGMDIADYPLQPFSGINGLRRCLQSDRDSKMIIPDVLPIVLTMWDEARKAVGLPKFTTFPPILGRPGRKRSDSTATQTMKSNDGKDMAKSTIKQTMDEFVLLVDELYDKRPLFKEICNKQETQDFFVQVLFLNVCQTNSMLVEDELNAKDAVLANAEIDPATPSSAVSSPVDGSSYFGRSNGADDTASIDSATMSPGRMIKRGGTSALTTKTSPHVSRRTQTFTLRLKSASWSQNSFFQNTRSLQEPVSDPLLDFVVKVCVQSIFNPQDKSQTGLSLVMNAFPPSTHEQQLYFESYLMTHIAQNVKSGLQLDEELLLDQRILNNVAKFGQIAADAAIQGRFRVGGIEQTYDLLASILEILHSDGLYSRYSANDTSIITIYRSFNRMILAKISDLEYGDNPMKVAAFLDYCIHHQKIILSAKNTDGEFLRCFCYHLYYYLQSTNGQVKDAAANIWKLLLLQKPEDIALLFAVRIKGFECDDLNDGFRQMLEMDLNSFYTWLDSRKVELNVLFNEYVCKSWEQFIVQELKNSREMLKSYVARRINKLRRTQRRESHEREVLNEYTKKSTTWSQEIQEIEMNRFMKALQDFDGHENFIHNEWIRISEDLTRERAIWGPEKAMNITWRLDNTEGPNRMRKRLQCVSNVTHQPYLPKLASRSKLSPLSTSVGSSLKKKTAAESKTSPKDSAQQTEKTSADSDHSLIDDESDSHEDNDEQLFYEEDKSRKVLRLLDQGDMVLDVYNVSQIAGVDACEGLLLLCNNNIYLIDNFFQRNDGEVVEIWDVPKEERDQYLLLIARAAGMETEQLENTTGEHTCRKWPAADLRDVFKRRFLFRDVALEMFFKDGQNALITVALSERDELYSKLVARIESHEESANTIFQGEIENTSSLSSTFRLSSLFGTSTLNDLVQRWERREISNFQYLMYLNAIAGRSYNDITQYPVFPWILADYKSDELDLSNPKTFRDLTKPMGAQTEERRREFEDRYRQWGETGDPTPAFHYGTHYSSAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFA6</accession>
    <name>A0A367KFA6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial succinate-fumarate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_011643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000037">
        <property type="protein sequence ID" value="RCI00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFA6"/>
    <dbReference type="STRING" id="86630.A0A367KFA6"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35313" checksum="C4F1E2A7B112ED67" modified="2018-11-07" version="1">MSRNGDSKQKTPLLTHLVAGGAAGFMEACTCHPLDTIKVRMQLAKNAARGASGKPLGFIGVGVKIVKTESFWALYKGLGAVVAGIVPKMAIRFSSFELYKSWMADAEGKVSTTAVFFAGLAAGTTEAILVVSPMDLIKIRLQAQRHSMADPMDIPKYRNAPHAAYTIIREEGVRALYKGVTLTALRQATNQAANFTAYQEFKKIARNYQNLDELPSYQHLILGGISGAMGPLSNAPIDTIKTRIQKSSSTGSGWERFKVVTMEIWQKEGFRAFYKGLTPRVLRVAPGQAVTFMVYEKVKSWLDIFQAKVENGEVTSLVSSPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFB4</accession>
    <name>A0A367KFB4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Thioredoxin-transmembrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TMX4</name>
        <name evidence="14" type="ORF">CU097_015492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000038">
        <property type="protein sequence ID" value="RCI00831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFB4"/>
    <dbReference type="STRING" id="86630.A0A367KFB4"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016711027" evidence="12">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI00831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="16106" checksum="A14E884E5344B41A" modified="2018-11-07" version="1">MRTTGVIVLLFGLIALCWAAVELTDDNFSKVVGKQDEWLVDFYADWCGYCQRFESTFDEAERQLQLSNYKHVQVGKVNVDTNPGLAARFFISRLPTVVHIKDHQVRSLPSIKTVSDVVGFITLELWRQIDPKSGIVSPFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG12</accession>
    <name>A0A367KG12_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Component of the polarisome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SPA2_3</name>
        <name evidence="4" type="ORF">CU097_015643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000025">
        <property type="protein sequence ID" value="RCI01108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG12"/>
    <dbReference type="STRING" id="86630.A0A367KG12"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="603" mass="70061" checksum="40358D05C3051ED2" modified="2018-11-07" version="1">MAYSKSPPRSPQEDWLSRGPQSAKTYSTSSSRSMSYTSRSQSFASTRAYSLAHYENTARIYYMELRSYLKDILAQESIEGPQPERITARQKLTRLSNHQFHELAMDVYDEVTRRIKNDKYVPFLPVKEDFHPKRNQARQKLATIAVPRFKDLASDVFSELTRRYANLFQEDDSHLPPVPQMPMMDSKLYDKVQQPSKSTHIIPAKGTFNVETVDKFSDDETILNSPDRTYVNRSPIDQKEFFSRNNNSDEDVEKIRSEYEYKMSMMQNHIKQLQDKLEEKNDQRMDSIDRELLDQLQKVSLKDEEDQRVIRQMEEQYKKLDDKYQTLKQDYNKQQEAVREVKRETREMIEELKRMAKTNEELMLEKEEADKEIKTLRDQVKEWQIKYEKVRLELRSVKAQSIRNVSSINCNMIKDNFIQPTKKGIITYDHILSFQTSIDELLITARSSYPANVIQAMKVIVSVCKLITEQVENNENRLTTDSKQTLYELKSRFSTALSDLLIAAKHHANGMGISPVSLLDHSAGNLSAVVVDLVRLVGMKDTDNNNQKGFQNDYNNNNTTSAYETNSNSPPSLSQIRSQLKDTDDNYSLPEQTYITPAELTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG42</accession>
    <name>A0A367KG42_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="12">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MCR1_6</name>
        <name evidence="14" type="ORF">CU097_015457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000039">
        <property type="protein sequence ID" value="RCI00812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG42"/>
    <dbReference type="STRING" id="86630.A0A367KG42"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI00812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="316" mass="36684" checksum="57273ED91F60EE4A" modified="2018-11-07" version="1">MFKPLYRSFISTCQHRSFTTSTFNNKKRQSLPVATTTAAILATACLGYYGWQYFENKGPKALNPDRYIPFDLVQKQKISPDSYRLRVSIKQEENRSYPIPSCLYIKDDTIQVMRPYTPINANPYKDGYIDFIVKRYENGSVSRTISGFEPQADQIHIRGPMTEEYEYRENSLDEIGMIAGGTGISPMYQIIRHILENPNDKNTRIWLIYGNKTMNDILLKSELDELQKKYSDRLNVKYVLEHPPDDNWKDVGYVTKEMIKSMMSQDENIRRKVFVCGPDPMLRWVSGERAIDYSQGQLSGLLSQLGLSSKEVWKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGB3</accession>
    <name>A0A367KGB3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS22_2</name>
        <name evidence="5" type="ORF">CU097_015705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000020">
        <property type="protein sequence ID" value="RCI01217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGB3"/>
    <dbReference type="STRING" id="86630.A0A367KGB3"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_uS8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="14813" checksum="ABB79EE11306D914" modified="2018-11-07" version="1">MVRVSVLNDCLNSINNAERRGKRQVLVRPSSKVIIKFLSVMQKHGYIGEFEEIDDHRSGKIVIQLNGRLNKCGVISPRFNIKLTELEKWTANLLPARQFGYLILTTSAGIMDHEEARQKHTGGKILGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGD8</accession>
    <name>A0A367KGD8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000034">
        <property type="protein sequence ID" value="RCI00912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGD8"/>
    <dbReference type="STRING" id="86630.A0A367KGD8"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="1">
        <location>
            <begin position="265"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="359" mass="40065" checksum="90464347CCBA6459" modified="2018-11-07" version="1">MTQSNILSPPMTPKRKVEAWFCNPVDRKDFIPPDSVPDSPPSSTLSAFNLQTCELQKDGQSRDGLDAYIVQPLLRASYAIHPRQSPPLCRQKRKPKCSLPTTTQGSFTIPIAYLLKQQMPLATPCNKVVFQDQTRKRKNRNMPCTTKRKLLRLAASDISSSKSVAKSRNREPKAVYHVTSSSLTDGNVSGDLPSRACDQNLLQENDQGDMENEDVQTGAINSNKAKRDAAYFFDQVAADSDIATIFKGKEDWIPKVDALENRAGIRVAWKGSPLKIQSMPYFEKLHPGEVPIASGLRLTPEQYLRCKYALILAAHKASQNNSLFRRSEAQKACCIDVNKASVLWKVFGKLGWLGSKWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGE5</accession>
    <name>A0A367KGE5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FCJ1_3</name>
        <name evidence="12" type="ORF">CU097_012278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000016">
        <property type="protein sequence ID" value="RCI01295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGE5"/>
    <dbReference type="STRING" id="86630.A0A367KGE5"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI01295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="577" mass="64479" checksum="953ED97F7012C30F" modified="2018-11-07" version="1">MLRASKVYNGAIRSSLQSKQPLGTIMTKRFETTVAQETPKKSKFFGKFVGVTVLLGAGFGGTTYYALHDKEFRKAFTTYVPGAKEAVDFAEDVQKNYNIDQYMNQASDWKRQAEDIANTAKEYTTKIQETTNGYYQALTGQKGSDRPDSKHLVPAEAVVEKHALSTPTDTVTTMSMSSDKETKPAVVEVAIEKPEPIQVKMIKSDNTTVRELSQIVVELASILNQSGLSGLGREVIKEAESKIEKLNESFLAIDAEQAAILKSIQSLKEKGDKVEGSLEEFRAEALKTIDDSQAVAASTIIAREAQLRNQFEQTRVEMKNSFAQQLAAELAAQQEQLEKARSEALVEQANELQRRFVKEVKLLVEQERAGRLAKLDQIAQRFKALEQYTLQNSQALDNSRQSHVIHITLNALQDALNAQQKQPFVDELQALSHNAKNDQVIQTVLKVIPKELAEEGVNTVSELAVRFEEVAQEIRRVALVPEDGGFGSHIISSLMSYLMFKKSGLVEGDDVESILARAEYYLKRDNLEYATRELNQLGGWPKRLARDWIQSARRHLEVKQALEVAETQAVLLSLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGX3</accession>
    <name>A0A367KGX3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_013583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000008">
        <property type="protein sequence ID" value="RCI01473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGX3"/>
    <dbReference type="STRING" id="86630.A0A367KGX3"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="190"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI01473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="420" mass="47045" checksum="D130CD942D486308" modified="2018-11-07" version="1">MSAFVTIIHFRSSLYAMSKSAPASLYMCSANVSLETREEKESIVEELEDGADKNDKDDLNEKGHVSNTSTLFSIICVVAGTGILAIAHALSRSGWIGLLFLFTSAVMSHYTGVLLIRCLYAIPGKRLTGYADIGYAAFGKPGSIIGFLFSQLMLFLTPTIYIMMASENLSQILMDYGLIWFHRRTFVASMATVCFILIVCVISDMKKAPGTSHAVVVPQNLPMTFSTFSFSYCGHVIYPHLEQSMRMPKRWPQVLLVSTCTISLFYFTIGCIGYWVYGNQVESPIYASLPSNAAQHVAMLVITLHVLLTVPFYLYVFTLPFEGQRRRKWKRLMMRAAEMVGCGLVAILVPFRFSDLMNLVGTLVTDILTFVLPILFYIKLKPQLRWYDWMMCILTVSMGIFCGAFGTLDAIQVMMSHVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH34</accession>
    <name>A0A367KH34_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonucleotide-diphosphate reductase (RNR), small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RNR2_2</name>
        <name evidence="4" type="ORF">CU097_011310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000008">
        <property type="protein sequence ID" value="RCI01469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH34"/>
    <dbReference type="STRING" id="86630.A0A367KH34"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="348" mass="40385" checksum="65166141AF91F2F5" modified="2018-11-07" version="1">MSIEAATEKIQALSLDKKTERHPDDQQEEILRENTRRFCLFPIKYHEIWQFYKKAEASFWTAEEIDLSKDLHDWENKMTENERFFISRVLAFFAGSDGIVNENLVQNFCDEVKIPEAKCFYGFQIMIENIHAETYSLLIDTYIKDNQEKEMLFSAIDTIPCIKRKADWAFKWISSNGSFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELICRDEGLHTDFACLLFTHLRKRPSQERVKDIILEAVSIEQEFLTDALPVALIGMNSALMCQYIEFVADRLMVALGFDKIYMATNPFDFMDMISLQGKTNFFEKRVSDYQRAGVMNKQPAEKTFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH89</accession>
    <name>A0A367KH89_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZDHHC14_3</name>
        <name evidence="13" type="ORF">CU097_009107</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000003">
        <property type="protein sequence ID" value="RCI01593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH89"/>
    <dbReference type="STRING" id="86630.A0A367KH89"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="236"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI01593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="413" mass="47570" checksum="3636E434BB00AE3C" modified="2018-11-07" version="1">MDVHKRHSLFNRTQEQASFTVFQPGFFNSELEPESLEDFDFEKAPNHNPAVNTITEEDDPIPHSSGVTYHSVVTSCGSAAPMINQQQPPLPESVEEYDMQPIDQKVLKERPVKNYQIFPGNTRFLCGGRLVTSKDYRAFIIALILFITPAALFCVFTCPFLWNQVHPVIPIVFAYLFILAFASMLKTSWTDPGIIPRNLDIPQQEMIDENASSIHASIMSDIAQKQIRIKNTSWSLRYCETCKIYRPPRASHCRQCDNCVEYEDHHCIWLNNCVGKRNYRPFFIFIVTCVILCIYVIAFDVYYLLSIASNSPNRGFGFVFSQAPVSFVLSIYCFFLLWMVGGLTIYHCSLIMRGVTTHEQLRRDIFKLTYPDLGANPYNKRNPLKNMVQVLCQPQPKSYLRRRKMADPVIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKA0</accession>
    <name>A0A367IKA0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005417">
        <property type="protein sequence ID" value="RCH78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKA0"/>
    <dbReference type="STRING" id="86630.A0A367IKA0"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH78105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="14846" checksum="714ABCF4D6021189" modified="2018-11-07" version="1" fragment="single">NGIRLHYVDQNPTSNKVLLLIHGWPDLWIAWREQIPFLVNLGYRVIVPSLRGFGESDAPEDPAEYGFGVVSRDLAGLLDHLQIPTVIVIGHDWGGAVTWRFGQFYPERVKALASFCTPYVPPAQHPTTLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPF8</accession>
    <name>A0A367IPF8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PFY1_1</name>
        <name evidence="8" type="ORF">CU097_003301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004530">
        <property type="protein sequence ID" value="RCH79391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPF8"/>
    <dbReference type="STRING" id="86630.A0A367IPF8"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH79391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="13484" checksum="4A28B1962095004A" modified="2018-11-07" version="1" fragment="single">MSWQAYVDTNLVGTGNVAQAAICGLEGGVWASSPGFQLHPSEIREILEGFKNPDSVRASGLHIGNAKYFVLQADDKIIYIKKGNEGACIAKTGKAFLIGTYNDKMQPGKCNVVVEGLADYLISVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQ84</accession>
    <name>A0A367IQ84_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline ceramidase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACER3</name>
        <name evidence="10" type="ORF">CU097_003759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004250">
        <property type="protein sequence ID" value="RCH79848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQ84"/>
    <dbReference type="STRING" id="86630.A0A367IQ84"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH79848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="94" mass="10855" checksum="07E694AD5BBAF9FD" modified="2018-11-07" version="1">MTKADHYWGPVTSSVDWCEENYLYSAYIAEFWNTISSFAMVIFGCLGACLHWQSLGWKLSAGYLFIVIVGIGSILFHGTLQFQYQMWDEVHTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRZ6</accession>
    <name>A0A367IRZ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_000243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003940">
        <property type="protein sequence ID" value="RCH80399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRZ6"/>
    <dbReference type="STRING" id="86630.A0A367IRZ6"/>
    <dbReference type="OrthoDB" id="2263899at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="219"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH80399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="633" mass="71267" checksum="A7C90D0DC6AFBE2D" modified="2018-11-07" version="1" fragment="single">MMGLVLDAGKFFTFFIILVVTNLCMNGFFRFWGAVSPNFFTASQLSSILLIAALVYSGYQIPYNKMHPWLMWIYWINPLAYGYKALISNELTGMNFSCEGANSVPFGPSYTDAAYKTCNLPGAVPGQTHVLGDYYLHYAYGYETWQRWIDFVAVILFFVFFTVLTALAMEYVDLQKEGSVTKVYKAGKAPKEIDESKALEAVQTEQEEEMESVSTGTTFSWHHIDYTVPVKGGQLKLLNDIGGIVKPGHLTALMGSSGAGKTTLLDVLAQRKTIGKVEGRMYLNGEPLGPDFERSTGYCEQMDVHNPNATVREALKFSAYLRQPAEVPKEEKDAYVEQIIRLMEMEKIADALVGDLEAGIGISVEERKRLTIATELVGKPKLLFLDEPTSGLDAQSSYNIVRFIRKLADAGWPVLCTIHQPSATLFEHFDHLVLLVRGGKTAYFGEIGKDASTMISYFERNGGPKCPPNANPAEYILECVGAGTAGKAKADWAEIWKASPEAKALEEELEQIHQTVDHSRKNTNSPYSLSFFQQFWLVYKRMNVSWWRCPTYNMGRLFNVCFIGLISGFSFWKLGNTPSDLQNRMFSVFTTLLMSNALIILAQPRFMQERAWFRREYASRYYGWAPFALSCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV47</accession>
    <name>A0A367IV47_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003407">
        <property type="protein sequence ID" value="RCH81496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV47"/>
    <dbReference type="OrthoDB" id="2287056at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="14320" checksum="E914C503B40F1E97" modified="2018-11-07" version="1">MKKGRSGMANKDDRRLAAALIKAKKEERWKDFNELEVLRQELKALRREEYTCRNSLKYTIRKQHSDDSVNLTTELKQTRFSGTDYGFKTMSVMVPISMKMFNTHLSLYNKFHPDNSLKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVK1</accession>
    <name>A0A367IVK1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003301">
        <property type="protein sequence ID" value="RCH81745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVK1"/>
    <dbReference type="STRING" id="86630.A0A367IVK1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="18625" checksum="83285173E01D48CC" modified="2018-11-07" version="1">MAISITDKRRVALAYDGSEDAHKLFDWTIQNVIRPESDHLILLSAVQRTNKPQAAKRSPSPDLPMLSTTITKVDEAMKETEHQPTARERLEQMSSQLRKQNISSEEHILWGDPRVLLPRYTQAHKVDLLVVGSRGLGVVKSVILGSVSDACLKECPCPVLVVRHATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW94</accession>
    <name>A0A367IW94_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003302">
        <property type="protein sequence ID" value="RCH81741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW94"/>
    <dbReference type="STRING" id="86630.A0A367IW94"/>
    <dbReference type="OrthoDB" id="2286379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="32365" checksum="308B86D61D5F7FFA" modified="2018-11-07" version="1" fragment="single">FNDIMKMHVFETPSRQAQELDPLYQIRSIVQAINDHIAKCIIPGKYLVIDEFMNQWLGTDMPNLKKVLRKPHPIGQEFKTLADNHCYCILRMKKLTITVKRLVKPWFGFGRTVIADSWFGSPDMVSMLMNHGLYSIMQVTKHRYWPQGMFETDIIQATGRCLFALLGLKKLTGEKTFKSSDGNQVTINRTKVVDEYERHRLGSVDAANNLRDNLTSYHDIISTERRVFSEEGASRGHLSFKDNLAFNLLEHCKKLKLSYMKWPNVATECLEVILIIHTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWM2</accession>
    <name>A0A367IWM2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003155">
        <property type="protein sequence ID" value="RCH82093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWM2"/>
    <dbReference type="STRING" id="86630.A0A367IWM2"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="184" mass="20804" checksum="BE5304CFE7C444E1" modified="2018-11-07" version="1" fragment="single">NVEYFVVDGHDADKWFDETGQSPFDAVFSSATLHWLKRDPVKAIKSIHHTLKPGGRLVAELGGFMNCASVHTALIAALNVRGIDGAAYSPWFFPSPEYYSQLLTDNGFKVLNAELIPRPTELETDVAGWIETFGFNFLNALDSDSERKKMVAEIQEYLRPAHQREDGKWFLLYTRLRVVAVKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZU2</accession>
    <name>A0A367IZU2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgi pH regulator B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GPR89B</name>
        <name evidence="4" type="ORF">CU097_001897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002740">
        <property type="protein sequence ID" value="RCH83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZU2"/>
    <dbReference type="STRING" id="86630.A0A367IZU2"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="3">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="25583" checksum="3D6016231660661F" modified="2018-11-07" version="1">MRRTSLVTLFVPWSQVYTFLKVNKGWKHRPAAYIASVATCGYLYMLIDIPTTINTSSMIELSIIRTSMIGVTVISILSGFGMANAPLTAWYQRHVSEHDYRIAERAYAQTNKMIAEKKMALDRMKQQQERQSSTEQASTSGYVGRFVSSLFGKGKNQEMELLQTEIEQLEGLAVSMNNDLEELERGRARTKYAKTWKGKVYCDNGGCCATKTKFDGPDHTNTIDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0H1</accession>
    <name>A0A367J0H1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GUT1_2</name>
        <name evidence="13" type="ORF">CU097_004300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002658">
        <property type="protein sequence ID" value="RCH83448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0H1"/>
    <dbReference type="STRING" id="86630.A0A367J0H1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="275"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH83448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="523" mass="57699" checksum="D3CC37F129FE97C6" modified="2018-11-07" version="1">MTKKQFVGAIDQGTTSTRFVIFDENGKMLTYHQMEFEQHYLHPGWVEHDPYDILASVDTCIEHAIRKLSILGYDASSISCVGITNQRETTVAWDSETGQPLCPAIVWSDGRTAKTVQELASQKNLPKERQGVDALREICGLPITTYFSAVKLRWMLDHVPEVKQAYDQNRLQFGTIDTWLIYNLTGGVENNGALVTDVTNASRTMLMDINTLQWSDEAINFFGFKGIRLAKIVPSSSIYGKIHSGSLKGVPIAGCLGDQQSALVGQKCFHVGDAKNTYGTGCFMLFNTGASPVLSRNGLLTTVAYQFGNEKPSYALEGSVAVAGSSIQWLRDSLGIIDESKEISSLAERVEDTAGVYFVTAFTGLFAPYWRDDARGTICGLTQFTKREHIARATLEAVCYQSRAILEAMNKDSKTPLRSLKVDGGVSNSDICMQIQADILNIEVDRPQMRETTALGAAIAAGIATGIWKNIDEVHRVNTEGRTVFKPRISEEQRNKMYTGWKEAVTRSLGWANVVSGILDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J118</accession>
    <name>A0A367J118_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002598">
        <property type="protein sequence ID" value="RCH83638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J118"/>
    <dbReference type="OrthoDB" id="2287485at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10493" checksum="08C88DF783C8BC2F" modified="2018-11-07" version="1" fragment="single">TEVAASKNRRNIQIANMLHTVVPLLLLAKNELSSSALREFYNVNGKSQTYKNYSYESLSKLTFSCRENGRLSQQNEENFGKVKPDYAAYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1N1</accession>
    <name>A0A367J1N1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">POLR3D</name>
        <name evidence="6" type="ORF">CU097_006453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002535">
        <property type="protein sequence ID" value="RCH83858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1N1"/>
    <dbReference type="STRING" id="86630.A0A367J1N1"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="437" mass="47789" checksum="EF4A8F9C66D23B76" modified="2018-11-07" version="1">MSDSTDNLSPGVKKQTRRFAPVKRGGGPSKPRTSEPEVKSESTEQQKSTTIGTMRPESVTSGRLQSVNEGQKTRGGAVKMKFKPTVPLKRNKKEVTSSAIDEALNSKQKDNRVGRGRGDGFGRGGGRGRGRGRGRGLIIEEVTASGIFSLGPSAVARSGTSRPGYGGGGFATYGGDVGNRVEADSTGTDMVEMFTEGATEYTPVTFPHVSRLEGDVDPITLSQKVGKIPWMTVRSKKEEDDDNVKVKEEQEDGMAIDEAKEEVKTEHKKKVYMNSDAPAQNIFALDEKDRLVCVAEEELLYFQLPTVVPKFEAKKQEVKEIKDEEAVKVEKTEQNVPPGARKPTLEDAMASLALEDMPEGQIGKLIVYKSGKMKMQFGNILLDVTQGMHSSFLENVMVVDHESEETKKAIELGHIVQKFVCSPNMDSLLKEAEEAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2C8</accession>
    <name>A0A367J2C8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002463">
        <property type="protein sequence ID" value="RCH84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2C8"/>
    <dbReference type="OrthoDB" id="10296986at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="56" mass="6661" checksum="335F1A1E9A9C59E7" modified="2018-11-07" version="1" fragment="single">MELVPLPWMQHEAESNNDSNQQQHWIFRTGWTPGPEQLEKMWCSNCGAYARKDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J354</accession>
    <name>A0A367J354_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002380">
        <property type="protein sequence ID" value="RCH84384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J354"/>
    <dbReference type="STRING" id="86630.A0A367J354"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="70"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="49704" checksum="3C8801137C67641D" modified="2018-11-07" version="1">MNKSIRYLDTDRSSSSSSISILYRDAMTVSGDEEGYCYYDIYPSSETSTFVSNDKVQYSSIDTQDDHQPCSFWGASLNLINAMMGTGILGLPLALHLCGIWLGLALSVGVAYMTCMIMHITILCGQRTHAFSLMELCRALTGKAGAIAVNCIIFLHTAGTAASYYIILGEVMPQLLKSMFPGIACYINKRNVVLVFGLCCTLPLSLTRSTACLAKWSAISLFILLAMTLGVLIRVPAYYDSDNVDLRFTMPTDPFRGLAIMSLCFGCAPNLFGIYVTSKRALWSKTCYLAILIAYIINVSFGVLAYLCFGKLVQDNVLLNFPRDDFIIQWINITLSLFMVLTLPLCIHPCRDATMMMFGISTHGATNKQHYLITFGVLAIILYAGCTLDSLGKVYDVLGGFSTIILGFLLPGLAYLTLFRFDESRMLYITSILAVIMSIPIIYFSLKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3G0</accession>
    <name>A0A367J3G0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL7_3</name>
        <name evidence="6" type="ORF">CU097_005275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002356">
        <property type="protein sequence ID" value="RCH84470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3G0"/>
    <dbReference type="STRING" id="86630.A0A367J3G0"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.15.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="249" mass="28440" checksum="5E400B0AB284A3ED" modified="2018-11-07" version="1">MAAYTVPTANDVLVPETLLKKNKANAKAAEAAAAKKAELRKAKIAKRREIFKRAAKYHAEYKANERREIALRRQAKATGNYYVPAQEKLVFVVRIRGINNIAPKPRKVLQLLRLLQINNGVFVRVNKATSEMLQLVQPYVTYGSPNLKTIRELIYKRGFAKINGQRIPIHDNSVIEQALGKYGIICVEDLIHEIATVGPHFKEANNFLWPFKLSNPNNMWKRRKFRHFIEGGDAGNREHFINNLVQAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3I3</accession>
    <name>A0A367J3I3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002374">
        <property type="protein sequence ID" value="RCH84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3I3"/>
    <dbReference type="STRING" id="86630.A0A367J3I3"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="40"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="776" mass="88199" checksum="C52443F717052840" modified="2018-11-07" version="1">MADLTIPTPPRTPTELPTPSSSSASLKTSFSNKSTSIKENVQVMVRCRPKSKKELEEEPCWIIDTRQGTIELARITSTARSFQFDNVMMGEGNEQVYKAGIQDLVRSTMMGYNGTVFAYGQTASGTEKEPGVIPRAVEEVFSYIEEDTSGREYLLRVSYMEIYNERIKDLLSDENTSPEIVEDRKKGNYVRNLKEEIVKTSQDVINCIKKGEGNRHISATDYNERSSRSHTIFQLMIESRPKSIGSKTNIVRFSQLNLIDLAGSEKVTSDVERRKEGAYINKSLLTLGNVISKLTSDSPPMHIPFRDSKLTRILQTALSGNARISVICTINPTLSSKDESMNTLKFAQRAKLIKTDAKMTKIGEHSELQKYLRTIAELQTRMQEKNDLETETKKRLENLLSLILTSSKGTNKDEERDNFQIVSFVPKDCTIEEVARRCEEGFAAKCEAHTREMQRKTEIIDQLESTVQVLESINSQKAEILAKREAQIELLNKKLHEKSTTSVQHLMAALQKAGVEQPQMQRALETLFLSVHPEDISKSKEIITQSIIQQQQKQAQQQQQKKQKEQQKGHETEQKLEQQVEQQANVQADSQKKSQANIQANIQIDTQAEQQVEQQAELQAELQADSQEDTRTNSQTEQQTQSMTTPLAEQQASPLATQAELQAEQAIYTKPKVSSQLFISIQEACTYCPLPAFTIYQPIEEYSCPDLVEDGNASDITEHGHSRENSFWEEQSYKTDSEVEEIDKVYSPYAEHIQQTLFYLPNWILVAWCIFYLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3P2</accession>
    <name>A0A367J3P2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CTU2_1</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="3" type="synonym">NCS2</name>
        <name evidence="4" type="ORF">CU097_000026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002339">
        <property type="protein sequence ID" value="RCH84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3P2"/>
    <dbReference type="STRING" id="86630.A0A367J3P2"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="416" mass="47255" checksum="FC6CA7C71E6C62EE" modified="2018-11-07" version="1">MYQYVGKYRSILIRLRHGSRKKGKVLLACSGGPSSISLVDLTKNIMHTLPNEKKKIQVVPEAVICHIDESSLFDPMSDSAETLRARMKEHYPNFEFICHPIEDVFSPQFVKNVNFDKYLSSEGTENGDYEHWAEYAYKTPSVDHKEQLQSLFNSIKKTTAKEDLLWHMKMQMLVTVAQREGCTYIFFADSATRQAIKMISWTAKGRGYSLPLDISVDNEQTFGVGIIRPMKDMLSKEVGFYNYFSGIDKLVIPPYNFGTMMPAKTSIDRLTEDFINGLERDFPSTVSTVCRTVGKLTPSKDMNYKQTCAMCLMPRQTGIGEWRKHITVTEVPGADTKPSDDGCCGNSQSCSTTNGCKGNKVDINQHLCYSCQVNFKDYNATTIQLLPPYVVENTQEQSRDERLLNEIKDFLINDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4U6</accession>
    <name>A0A367J4U6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_005525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002230">
        <property type="protein sequence ID" value="RCH84925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4U6"/>
    <dbReference type="STRING" id="86630.A0A367J4U6"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51274" checksum="D907CEF095176ACC" modified="2018-11-07" version="1">MAFKLPFRYSDPNVQVFLVGFICFCCPGMFNALNGMGGAGQADPKVTNDANTALAVTFTVCSLIGAPIFNILGHRVLVPAALTYVLYVGSYLTPNPGFTIATGAILGIGAGLLWTAQAGIMMSYPDEKDKGKAFSIFWMTFNLGATVGAAISLGNNFNNTTSTVSIGTYIGFMCIMGFGAFLSLALLPARKVIRSNGTPVSLHKFSNWRREAVEIFALFRDWRMICLIPLFAGSNWFYTYQFQVYNGGGFFSLPARSLNNLVYWLCQIIGAGFFGWLLDFNKLGNRKSRAFFGNTVVLSALCAAWIGAIFVQKKFTRESVALANFEKVDINSDGYAGYVILYAIFGLVDAIYQGFIYWLLGTMTNDTERAARYGGFYKTIQNAANAIAAQVDATHVPFMTQLIINFAIEGVGLLLAYIVCFQVSDVTVEEVDNLVNDQGTEIMIAGQVENVGESQKNIKVEHVDHIIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5A3</accession>
    <name>A0A367J5A3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CU097_007040</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002179">
        <property type="protein sequence ID" value="RCH85118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5A3"/>
    <dbReference type="STRING" id="86630.A0A367J5A3"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="698"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH85118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="894" mass="97553" checksum="3E0ABB8013278C1C" modified="2018-11-07" version="1" fragment="single">VVSFVFKDYVEGGVICAIMFINAGVGFMQEFKAEKTMDSLRQMASPTSQVIRDGHQKTIPTRELVPGDILILKSGDVIGADCRIIEAFNMDVDEALLTGESVPVNKATDAIQGEDVPLGDRINMGYSSTVLTKGRGKAIVTATGMQTEIGKIAKRLLDSGDSTKTPLQKSLDRMALVLLAVAIISIIIVFGAAKFHINDEVILYAISTSIAVIPEGLVAVVTLTQAFGVYSMAKSKALVRRLAALELLGSVTNVCSDKTGTLTQSKMVLTRLWRPNAGFYSVSGIGFTIEGQVKLESSDTIVTRENMDQGFQTLVNTAALCNMSEVRKDKQTNEWSGIGDPTEIALQVFAHKLQNGKPSLIKKNNSDEGWELVAEYPFDSSVKRMSVLCRAPNGKSIAFLKGATERVLDCCVGVQMSDEHDIEFMSSQELQALVLPNVEALAKGGLRVLSLAYRRVKHEGQVTSDTFSREYIEQEMIFLGLVGIYDPPRAESKDAVDECHKAGITVHMLTGDHIATATAIAREVSILPATYGLDEDDEMYGRAKAAAKPHIGDGKTDLVMSAQRFDKLSVEQIDALPDLPLVIARCSPDTKVKMIEALHRRKKIAGMTGDGVNDSPSLKESDIGIAMGENGSDVAKQAADIVLVDDNFATIVKAIEEGRRVFGNVARFVVHMVSGNVAELTPLLLGLAFVDANGESVFPMSPVQILFNNIITSSPPAMSLGLEPIHKDQMLQPPRSRKDGLFSYSNLIDIHFYGVTIGIICLMNFIVVVYGWGTGNLGAGCNHYYSEACDEVFRARGALFATLTILILVHGFTCRDLRNPTWTWSALTGQQNKYLFWSTLFGLVLLVITLYVPVLNTDVFKHKPITWEWGMTAASVIVYIMIVEAYKGIKRKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7B7</accession>
    <name>A0A367J7B7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002012">
        <property type="protein sequence ID" value="RCH85800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7B7"/>
    <dbReference type="STRING" id="86630.A0A367J7B7"/>
    <dbReference type="OrthoDB" id="2281809at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="30908" checksum="183A006822459C86" modified="2018-11-07" version="1">MPPKQSQWNNPMLPHHTVPSMSFSSMSVEDILAHYEPTSDLSEHILLAKEQEEKRRTAEELRQTEEAHLQAKMLEYQFIHPHHHPHHESSSSMLGYVDHFPEQIIPTSSLSTEMNTLFSSDYHYNMIETTSAASSPSLEFVSITSPQPADLCHIPSSPPELPMFPASAPVVTSKPTQRKPRSSIHRTLSYESIMELNTNRPKQSPPPQQPLDHEKVMEALRAKLRKSSSPKPKSAPEPTPPPNTYPTTGVLFLDLKHRRRKASASKRNSYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J847</accession>
    <name>A0A367J847_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reticulon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_000992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001932">
        <property type="protein sequence ID" value="RCH86132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J847"/>
    <dbReference type="STRING" id="86630.A0A367J847"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH86132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="11701" checksum="E2B2A145A062D260" modified="2018-11-07" version="1" fragment="single">TSIKWLAISFTIWKISAHMSTVNIILFVTLSAFTFPRLYITNKDVVDSHLHKGQALIQNSLSKAQEAAKESINDTYAKARAMTAKAGTTGTDAKNTLNNSSVTVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J888</accession>
    <name>A0A367J888_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001936">
        <property type="protein sequence ID" value="RCH86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J888"/>
    <dbReference type="STRING" id="86630.A0A367J888"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="181" mass="20246" checksum="5FA060D2FEB347B9" modified="2018-11-07" version="1" fragment="single">KYRLLVRVARKFQRTQPNTSLSNNTGIPSTRVSPHSITKKTTRTEAKTSRLHGKCNYVTSNYKLAKELEVSNALIHMDASTSASKHSPASSAAYDDEIDGKIDEILEYDSLVKHTQCYSSLCNYQPCSKKTHTFLNKRTDSFFVLITIERAFTGVLADTGCNISTISPNLANFLKIKIPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8A6</accession>
    <name>A0A367J8A6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001924">
        <property type="protein sequence ID" value="RCH86173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8A6"/>
    <dbReference type="STRING" id="86630.A0A367J8A6"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="637" mass="71831" checksum="ED3D57C024CFA220" modified="2018-11-07" version="1">MLTRQYMLSRFGISKFTRAGYSTIATEQQPRTFSNQSKLPRLPIPDLQLTSARYKRTLLPLLTTTDYESVSTKIDRFFQPGGLAEKLQSRLYQLDEQEAKLGVNWLDRLWLKKAYLEYRIPTLINVNWWNQFKDPDTGLGKGAPDGQVTDFQFDRSASMIAGLVDYSNRVNNEQIPPDVSRSGPFCMHQLKNMFGTSRIAASGCDKVITQWPCLAKHINVIYKDQIFSVDVIGPNGETVPVKQIEQQLRQVVQQVEQTPVEQRQAAVGLLTTEHRDTWGPIREQMEKQTTNAKSLKNIDDSLFVFCLDDYSSPLDLDLSHRNIFHGRNGRNRWFDKALQFIVENNGRAGINGEHSPADAVIPSRIVDDVLAREPIQNSAASVPGLAQPKLLTWELSSSVQDAIHTAEDNASKLIQDLDSVLLHYHNYGSNFMKAAKVSPDAWLQMAYQLAYYRHYGKPCPTYESASTRKFLTGRTETVRSCSVETVAFTKAWDDKDVKLSDKLDLFQKAVTGHLEYMKAASSGHGVDRHLLGLRCQMTPEEAASDDAAIYQDPSYWGSQYWLLSTSNTSPGDMAWGGFGAVVPEGYGINYAIGKERIRMSVSSWNSYADTNSSSFRKTIQGVLDDFGDVAERYFIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8G7</accession>
    <name>A0A367J8G7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001920">
        <property type="protein sequence ID" value="RCH86195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8G7"/>
    <dbReference type="STRING" id="86630.A0A367J8G7"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="9139" checksum="C57BA0D5F21E04D3" modified="2018-11-07" version="1">MSEPKPGEALIKPEYRKERWFSDAETAVNDDEAEGASTIEPKKQKNARGANKGQRGKKRIEDSVRLCKYVAVDEECKIGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8N8</accession>
    <name>A0A367J8N8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001901">
        <property type="protein sequence ID" value="RCH86287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8N8"/>
    <dbReference type="OrthoDB" id="2289512at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="340" mass="38651" checksum="262A4571C9CACD9B" modified="2018-11-07" version="1">MHRSTEQQIKRTNENDIKDEQNALVSSKSRREFGASDKNINTPKLIRSDSFGLKPKASNSIEKNNEEQKKSVKREFGLSDKNVNAPILTRSDSFGLRSKDSNLKGKVKTTEDKQSLTLPTKRNKELDEELTTIMAEARTQRRREKDIGDDDWAPEGLDLDFSPFGEAPLMEPIKKNVPTSSMQSLMKKVLENTEEDVLDSDLQSPKLVDFPDTVEYGPPKEQELFDPPAAQIDLSHFSEFVADLDPHYYSNLPKEDVYAELKAAIAEVPDLFDQLATDDAPGFFEDVFDEFDLGFAQEEDDELTEEMRNPFHDYQFDIEHFIKHNPGAVHNPDIVIPGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9U5</accession>
    <name>A0A367J9U5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001833">
        <property type="protein sequence ID" value="RCH86599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9U5"/>
    <dbReference type="STRING" id="86630.A0A367J9U5"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016578637" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15315" checksum="58C1F8AB202A67F1" modified="2018-11-07" version="1">MKLCSFLLCILFALLATLASSQPVNDKRGLGALVGSIIHGVATLFDPVREGGSQGACGPFATKHSHIVALNAHDYGDLNKKSHWCGKKIKIMYKERTTVATITDACPGCDAGCLDLTQAVWNELGEDPKVGRLKIKWAPCDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBM3</accession>
    <name>A0A367JBM3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001689">
        <property type="protein sequence ID" value="RCH87285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBM3"/>
    <dbReference type="STRING" id="86630.A0A367JBM3"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="237" mass="26238" checksum="509A7158FAB467A8" modified="2018-11-07" version="1">MQLPNIIREPATALIGEACYSSLIQDLNLNDVECIKYVISKGLGLGIVLGGSIVKIPQILTIIKNHSASGLSLTSYFMETLSYFITLSYNLRQGNPFSTFGEIMFISLQNIIITCLILYFGRQQKQMMITLLGFLGLFYTLNQSVSPSVLSSLYALTIPLSLGSKVPQIYINFKNKSTGQLSVFTVINYFAGSAARVFTTMTELDDTLMLFGNLLAATFNAILVLQVILYNNKHKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCC4</accession>
    <name>A0A367JCC4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 9">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRM61_1</name>
        <name evidence="12" type="ORF">CU097_005126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 9"/>
    <dbReference type="EMBL" id="PJQL01001626">
        <property type="protein sequence ID" value="RCH87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCC4"/>
    <dbReference type="STRING" id="86630.A0A367JCC4"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000247">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000002">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="64"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="36599" checksum="35221403C998F74D" modified="2018-11-07" version="1">MSFNGWKKYIEEGDLVIVYMSRENMIPITIKKDQEFNNRFGTYKHNDIIGKEFGSKMVSSNYKGFVYLLHPTPELWTLVLPHRTQILYLADISFISTLLELKPGVSMIESGTGSGSFSHSIARTIAPHGKLYTFEYHEERAKLAEVEFKAHGYGDIIKVHHRDVCKDGFQLENLVDAVFLDLPAPWDAVASAKKAFKQDRTGKICCFSPCIEQVSKTVTALEQNEFIEITMYECLMKEHMVVPVQKLSFQDLIQEAKQKKLNGKDGSSVTVPVKRRLGKDEPIPTAEEVEESNQLMLTSRTPGETRGHTSYLTFATFLPSTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCH5</accession>
    <name>A0A367JCH5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ERAD-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001659">
        <property type="protein sequence ID" value="RCH87431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCH5"/>
    <dbReference type="STRING" id="86630.A0A367JCH5"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48394" checksum="6095481D4A6EF3E6" modified="2018-11-07" version="1">MTLEQEQQLLENIPDELKLIQCIDIIQTTNDLNTCLQALNYLRGKATKHQDTEAKTKLSLLYTEDHKYITKDSVEVIIWSRSVFDKQLSQALHQSSSAFTASRHTSGVQVIHEGTENDPNLCYLAGLLFTKGIGFEQNLERGIALLKYAATNGKLGEAACELGRIYGDRYRYSYHQLADSVYWFERGFECGSNQAIVDLAYSFFEGSQDVPRDDARAFRYAKDGALSNDKYCQYIVGHMYLKGRGVKEDAAEAMKWLDASAKQGFTVALEEQVAVYMHGAGNVPKDYKKAYQCCTQSIAANIPYCQVCLGDMYRNGWGVEQDFHKAFEYYQNAASTQQSDIPYSHAQHMIGEMFLHGEGVPKDLTVAKEWFQIASTHGYEPSQIKLQQISILEQNLLQQQREVLANGEGTTNQEKRSSRWSLGFFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD12</accession>
    <name>A0A367JD12_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001586">
        <property type="protein sequence ID" value="RCH87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD12"/>
    <dbReference type="STRING" id="86630.A0A367JD12"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF9">
        <property type="entry name" value="ZN-DEPENDENT HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60722" checksum="92664967AA1AFF5B" modified="2018-11-07" version="1">MTTTIRSLTDRLARFALYECTADLSHLHPKEHAALKHLVKAGKYIDQLYMRQAWSGNEALREKLQKEGNKDLCTLFEMYKGPWAREDDNVVFVDGAPKRPEGGNFYPEDMSKEEFESWVATLSEEEQKRAKSYYTVIRRDDKGQLKPVPYSEAYSDLLQPAAAHIRDAAEELKDVYEKGHEGTSIYEFLTSRAKAFETNDYMDSELDWLRLGKFNNLEITLGPYEQYTDGLFTFKSAYEFYIHVRDAHSSRLLEKFSDLQFVEDRLPIPEKYRNKDLVVAPIVVVNQLFSAGDVAVPMTAAYNLPNDEEVIKRGGSKLVLIKNVQEGKFEHVLKPIANQILAKDQLQYLSKDAFTTHVLLHEVCHSNGPHHTLDGHTIRSKLQEYHSAFEEAKADIAALFAADIMVDCGTIDNVTQEQFWVTFLASAFRSIRFGIQEAHGLGQAMQLNYLVEKGGFIYDDQDKVFRVDFEKIRPAVSDLTHDILVLQGDGDKQAVTAFLKKYGVLDVNTKDALDRIDHAGIPVDIRPSYPLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDR9</accession>
    <name>A0A367JDR9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001544">
        <property type="protein sequence ID" value="RCH88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDR9"/>
    <dbReference type="STRING" id="86630.A0A367JDR9"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="35456" checksum="962A717ABE62F892" modified="2018-11-07" version="1" fragment="single">HIYDLDSMTEKNEPIASAARMDQHKYAVTSLSWYPADNGLFVTSSYDSTIKVWDTNEMKAVEEFNMECRVHCQAMSGIANHSLVASAAAEPRIRLCDLANGSFTHSLTGHSGSVMSCVWSTNQEYVLYSGGSDGTIRVWDIRKASSCLMSLDQNNAVDQNPLGETNSAHGRGINGLTVTNDGRFLVSLGLDEKIRLWNTQSGHNTFVNYGSSWRNRFKLCLQPALSSPDVWPPLLYIPSDDRQVLVYRLMDGMLVKRLKGAYGRVTSVENRESHQQLYSGSNAGDLLVWEPPAMIAAVEEREVDADEWSDYNDEDDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF32</accession>
    <name>A0A367JF32_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001450">
        <property type="protein sequence ID" value="RCH88534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF32"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="11363" checksum="9D8A0D6B1B322C6D" modified="2018-11-07" version="1">MISSVSIKSTIEGSEPLSAGRTAEKDCAYASLEHTVAAADDNDDNFSAFPFFGMIDGTKVDGPVVEDEHKVFLCGKFEADEDASKGRLMEDVDDPNCWTCCSSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF36</accession>
    <name>A0A367JF36_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Steroid 5 alpha-reductase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SRD5A3</name>
        <name evidence="8" type="ORF">CU097_000003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001445">
        <property type="protein sequence ID" value="RCH88558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF36"/>
    <dbReference type="STRING" id="86630.A0A367JF36"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016803442" evidence="6">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="251" mass="29174" checksum="21909EDFAB40D63A" modified="2018-11-07" version="1" fragment="single">MYLIVLLCSCLIILTALSICANRFHELQASVLSYGKLNLHNTKKPKTRWAHYLSTLTVPKHYFNHFYIIGLLFGINCAIELYFQKGLVFYLLRQWDQPSGSHHLPQLQCQVGLLLVNFHLARRVYESLIIERPSKEARMHMSHYLTGVGFYGAMVLGTWLEGAVHLGVWPSRTIEKGIYIMFKSLYILISTGHWNLSTLIALLLFFYANYHQYQCHSILASLRSNSTERYSVPRGDWFEWIVVPHYFADIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFB8</accession>
    <name>A0A367JFB8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001433">
        <property type="protein sequence ID" value="RCH88626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFB8"/>
    <dbReference type="STRING" id="86630.A0A367JFB8"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="100"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="335" mass="37798" checksum="C04648EA3BCEFD60" modified="2018-11-07" version="1">MNKAPVLSSVGGLIIDDIYYPDGRKICNVLGGGGVFAIYGMRIWKPSPSSQEIGYIVQKGFDYPQEIDDQLNQLDISLISKYHPDKHTTHGINTFGANDHRDFEYKHPIIRITASDFSESWIKSLRVVHIISSAERAIEIINEWRQRDPESKTQFLWEPLPWACLPENLQEICEACQGVEIISPNHEETAEMLGYKFEELLSQHSNDFKQTVEYCARLLFDKVKKSTIKLVVRASKYGALVMTSGCMEWVPAYWDNRTDHDKVVDVTGAGNAFCGGYAAGWLHTHDPVRSALYGAVSASYVVEQIGVPSLVEPEQWNQGPSPMDRLSLLESKCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGD9</accession>
    <name>A0A367JGD9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GLA1_2</name>
        <name evidence="13" type="ORF">CU097_010703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001379">
        <property type="protein sequence ID" value="RCH88939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGD9"/>
    <dbReference type="STRING" id="86630.A0A367JGD9"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562317" description="glucan 1,4-alpha-glucosidase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="12">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH88939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="605" mass="65354" checksum="C6FABDDFAB9AFFE0" modified="2018-11-07" version="1">MKLMNPSMKACVFFILSYFSLLVSSAAVPTSAAVQVESYNYDGTTFSGRIFVKNIAYSKVVTVIHSDGSDNWNNNNNKVSAAYSEAISGSNYEYWTFSAKLSGIKQFYVKYEVSGSTYYDNNGTKNYQVQATSATSTTATATTTTATGTTTTSTGPTSTASVSFPTGNSTISSWIKNQEEISRFAMLRNINPPGSATGFIAASLSTAGPDYYYSWTRDSALTANVIAYEYNTTFTGNTTLLKYLKDYVTFSVKSQSVSTVCNCLGEPKFNADGSSFTGPWGRPQNDGPAERAVTFMLIADSYLTQTKDASYVTGTLKPAIFKDLDYVVSVWSNGCYDLWEEVNGVHFYTLMVMRKGLILGADFAARNGDSSRASTYKKTASTMESKISSFWSDSNNYIQVSQSVTAGVSKKGLDVSTLLAANIGSLPDGFFTPGSEKILATAVALENAFASLYPINSNLPSYLGNSIGRYPEDTYNGNGNSQGNPWFLAVNAYAELYYRAIKEWISNGKVTVSNISLPFFKKFDSSATSGKTYTAGTSDFNNLAQNIALGADRFLSTVKFHAYTNGSLSEEYDRSTGMSTGARDLTWSHASLITAAYAKAGSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGS8</accession>
    <name>A0A367JGS8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001341">
        <property type="protein sequence ID" value="RCH89144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGS8"/>
    <dbReference type="STRING" id="86630.A0A367JGS8"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31468" checksum="CE4C5EE493233626" modified="2018-11-07" version="1">MALRGSTITSLCIINCRLDFEMTELFCIIICAGHKLTSLYYENNDDQGIESPQLLQTLVMSTPNMKHFCGRHAGMNDVVLGTISRRWLSLETLTLYNLGKEGNSEGDSRNTLTNISHQAFLELLCQCKELRSLELYDLACITNRDLALYNKEVERLKSKSKTRYRPYPEKGAERRPGGSVCQLRVTKYNTTPLSMPGFHDLLRLFPNLVRLEYVTNFNTFYNQFEGVTLELFEAEKASVDCLMKSKSLIYEGRWYEPMTAEQYLTAGLLRSLGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGY5</accession>
    <name>A0A367JGY5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001341">
        <property type="protein sequence ID" value="RCH89145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGY5"/>
    <dbReference type="STRING" id="86630.A0A367JGY5"/>
    <dbReference type="OrthoDB" id="2385347at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="550" mass="63785" checksum="14C5EEFAD0C7A45F" modified="2018-11-07" version="1">MATNFSPIMLHHPTSTFQDKIQATPIIEVTQRLAPELYEYEFPPRSRIMAIESSIENDDEYFDESSFTTISTDFHDCYDPQLDNDQHQFDEDDDEVEEVDDLLYYINESFPNKTEFISDHQLSPLQLPSQYRRHDREESYDSTGTIKQNPLGPSSFLSAQHRQLYLERVPEEERINWDEHDYIFPTEDHHVVRNTSVHPYQLDDDDNDENQSIGSKVVLIKLSKTKPPMIIHQSDYSDEGYDDNEDDYRKELPIESSSKFIPLDDDDFLDSDTIRTLAAVKIQAAWRGYNYRRKQRLNPHYRVLAGLATINNTIHKQNYNHLLDRIHQLEHRLNEETAMRIAFEKAMEDMTILMDHQHKVLHERLEHEVNLRKTYEQKMEDTVSLIKPLETRLRNESKARADMESMMSRVLDQLHDLKSNFKKEAEEKKIMQHKLNEALDEVSSLKKLQISSQLPSRPSIVPSNRSPSVIPSKRTPMSNRSASVTSSIRSSVPSSRPTSRIASKPISRPVTPSANTIRRTVTPSSHQLSSTSRAAETTVKRSMLSSSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH44</accession>
    <name>A0A367JH44_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001328">
        <property type="protein sequence ID" value="RCH89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH44"/>
    <dbReference type="STRING" id="86630.A0A367JH44"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="224" mass="25498" checksum="0EAD05FAB10318D3" modified="2018-11-07" version="1">MVRIAVLGGSKGCSQAMVVQGLESKPHMQFKLLVRNPSKIDYTDKQKAKLTLIQGDALVHKDVEQTVRQTDIAVFSIGSAFDMKTRSMVTPDLCRDSMTVFLEVIDRLPEEDRPKRLVVVSTTGLDGMSEVPYLFRPMYRFLLHEPHMDKLELEKLVTGEKNKHIPNWILVRPSLLTDGGLKGKYRANEGISGYTVSRKDVGHFLLHQCLEEDKWLRKKVVVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHB9</accession>
    <name>A0A367JHB9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LYS4</name>
        <name evidence="21" type="ORF">CU097_008477</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="PJQL01001304">
        <property type="protein sequence ID" value="RCH89352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHB9"/>
    <dbReference type="STRING" id="86630.A0A367JHB9"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="33"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="504"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH89352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="695" mass="75691" checksum="C8EAE86CC6DAC67E" modified="2018-11-07" version="1">MFLAISRTNIIKRPLTFSYRRSYATTDHQNLIEKIVQKYAVDLPEGYKVKSGDYVTIRPHHVLTHDNTGAVIPKFKSIGATKIYDPKQPVYALDHDVQNKSEKNLQKYANIEAWGKQQGVDFYPAGRGIGHQVMIEEGYAFPNTLTVASDSHSNMYGGIGALGTPIVRTDAAAIWATGRTWWQIPPVVKVILEGQLPAGVTGKDVIITLCGLFNKDQVLNTAIEFHGEGLNGLSVEDRLAIANMTTEWGALAGVFPVDTKTIEYLRKRQRRLELTHFENKNLPPLKKGEKFVHPRINDQTIQALIDQPIEPSPKATYAKTLTLDLSTLSPHVSGPNSVKVATSLAELEKQDIKINKAYLVSCVNSRASDLKEAAQVLRGNKIKEGVEFYVAAASSEVQKEAQESGDWDTLIEAGAKVLPAGCGPCVGLGTGLLKDGEIGISATNRNFKGRMGSPNALAYLASPAVVAASALTGKISGPASSAKTTKQPSFSIQTHTSESSSDSNTAVQAEVLPNFPAIIKGEILFCHADNLNTDGIYPGKYTYNDDMTPEDMKKVVMENYDPNFVNVVKEGDVLVGGFNFGTGSSREQAATAIKSRGIQIMIAGSYSDIFKRNSVNNALLLIESPELVNDLKQALGTTDLTRRTGWKVDIHVAEGKVKVHKEDGQEKLYKVGALGKSVQEIWLANGLEGWVKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHW8</accession>
    <name>A0A367JHW8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001282">
        <property type="protein sequence ID" value="RCH89475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHW8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="10064" checksum="66FA7414B0B8A43C" modified="2018-11-07" version="1" fragment="single">MPAPNDSPKPNDIIINDDNLIQHIKNKILSMRLESVPSVALLYFSTSGWCDFNAHHEKKLSGFTSSFPCLSGQYGYLFQGLFEEDQQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ36</accession>
    <name>A0A367JJ36_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Blue light receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WC2_3</name>
        <name evidence="7" type="ORF">CU097_007640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001200">
        <property type="protein sequence ID" value="RCH89947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ36"/>
    <dbReference type="STRING" id="86630.A0A367JJ36"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052138">
        <property type="entry name" value="GATA_ZnFinger_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255:SF4">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="25837" checksum="D942DF1C197B270D" modified="2018-11-07" version="1">MSKPYLSRNGHLFDSMLEIKMENDRLKHCLRQLSSLSEQTVSNEKRDTQLPAFFWSDEEKNTLLEDNKMNNVKNDHSLKTFSSPLSPIANSKLAISAGSSSIISKEPSISSQEEWENPRGAHPIKKSPRSTILTTPAGNQIQNQTTVSLQPLSVDDKGNIPIKKSKRKQLRKYVCNDCGTTTSPEWRKGPDGPKTLSNACLDEDHRPNDIYNKKCTALNQYTDMIPIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ58</accession>
    <name>A0A367JJ58_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1206 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001202">
        <property type="protein sequence ID" value="RCH89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ58"/>
    <dbReference type="STRING" id="86630.A0A367JJ58"/>
    <dbReference type="OrthoDB" id="18869at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="93"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="188"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="3">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="418" mass="46977" checksum="501C13D89B0B5419" modified="2018-11-07" version="1">MLNCFINKRQNGNNENTLNATHDYNKLSFFKLFKKKRNTSLEEGNSVEPKTTSSTTEVTRGKGREIRRESDLHFYEGGVRTKHKTAIKWVGRVGFIAKGVVYGCIGVLTLTNLSGAWTPNGSEGNESPQGAFLLLGGIPAVGRTILIVMAVGLCLYIIWRFWEAITGQGSDASFSKKKNFFRYRLSPFVSGCVYTAYTYYVVHMIFQTEEEQQTSASSKTFPASWAESGIGKAGIVLLGIAFLIAFFTQMVNAVKGTFIKDLKTSEPNARKWEAFIVHWMGRIGFFGRAALFGTLSGFFWDSLAQRNESGEKNMVAAAVSKLANSGGGRFFMGLLGVTLVIYACFAISNAYYKYFPTPPPTRQEFYTNEFVHPELSDDDLEQQRRRMDRSNDTHISPFSIRRLFYFFKKKNNTEGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJF2</accession>
    <name>A0A367JJF2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011848</name>
        <name evidence="2" type="ORF">CU097_011859</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001182">
        <property type="protein sequence ID" value="RCH90068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01001180">
        <property type="protein sequence ID" value="RCH90079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJF2"/>
    <dbReference type="STRING" id="86630.A0A367JJF2"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="200" mass="23245" checksum="31AF76C5DD3B9CA3" modified="2018-11-07" version="1">MPKAVLYPLENYTLATKEPQPEEDPSVSARLRRLESDYNQHGMRRSVEAVLVVHQHNHPHVLMLQIANSFFKLPGHYLEPGVDEVEGLKEILNKRLGPEDPSEWDSKNDWTIGECLSTWWRPNYENYMYPYIPAHVTSPKEKKSLYIVHLPPSKVLSVPKNMKLLAVPLFELYDNSARYGAQLSTIAHLLSRYEFIYEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKW4</accession>
    <name>A0A367JKW4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001104">
        <property type="protein sequence ID" value="RCH90556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKW4"/>
    <dbReference type="STRING" id="86630.A0A367JKW4"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="340" mass="40071" checksum="6E9B2BE9C224F7CD" modified="2018-11-07" version="1" fragment="single">WESLFCKPSSNQKTSIQIEKDGRYLNRLTESIVSNGEIERIMQGCFESYPLMRFHDVAMQKVVRISEWLDFYDQLNQRTSERQEFELYKYLPYPLVNFHRFFAGTTMQEHRVEYPRMDYQVFSAKKQFENLIEIFLSGVDATKRRYLNKTIISKEFVPRLMHIISPDLRPVNKQLIKPEEKKVLARLVDIMIEYGLSFIQEKTEDGQFLYKLEPPVEQLLQFELSSPKSILPRQYAVRQMIAQEIETEILKRKEKMLALRGGVKKAPIDKSPAIKKVQNKPEKMAVDFFGRPIVKQKQKQSSNKMDVDDSQDTAKPVVSYKYHEGFSNAVRKPMTVQMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLA4</accession>
    <name>A0A367JLA4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATG7_2</name>
        <name evidence="10" type="ORF">CU097_011254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001079">
        <property type="protein sequence ID" value="RCH90717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLA4"/>
    <dbReference type="STRING" id="86630.A0A367JLA4"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="304"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="624" mass="70234" checksum="92C3CA02707AB638" modified="2018-11-07" version="1">MLKFTPLSSAVDASFWQSLATKKLDILKLSQEALVIQGHYSFPTTATDQQGQTVLMPSHFFIPSHGLDNTQDKDGIKGTLINTNTVEAFRTIDKNQLFQEATLKIKEAVESGEALKDPKKLYHYLLLTFADLKKYKFYYWFAFPAIIPDQDGWQLNHQQDLTSEQASVLHAAYQGQYYFLIKKETERMRILSLDAFEKNDQTIWFAFLDPSPVKGSPGWPLRNLLYLIYTVWGLKKVRILCYRQSDPYLIDASLPEHCSYQTTKSVGWERNVQGKLGPRMADLGPLMDPARLADTAIDLNLKLMRWRLMPELDLDKIKQTKCLLLGAGTLGCYVARCLMGWGVRHITFVDSGTVSYSNPVRQPLYRFQDKGKPKAQTAAEQLLEIQPTLVAKGYDLTIPMPGHTHNHLDQDLTTLTELIKEHDVIFLLTDSRESRWLPTLIGTKLNKWIINSALGFDSYLVMRHGTRQNQMGCYFCNDIVAPTDSLTDRTLDQQCTVTRPGLAAIAGALAVELMVSLLQDPKGIHAEASTNASNSSAGSILGLLPHQIRGFLGQFNNLLIVGQSYDKCTACSDKVLEAYSQDPLSFVQKVLDDPIYLEDITGLSALKAESENVLDDWTAEEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLC7</accession>
    <name>A0A367JLC7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_005027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001075">
        <property type="protein sequence ID" value="RCH90738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLC7"/>
    <dbReference type="STRING" id="86630.A0A367JLC7"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="379"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="52423" checksum="4416DA34921A668D" modified="2018-11-07" version="1">METVDINITNATLPPANHLLRPLIDSAQPRNNIREEEIQDKMMIDEQHPGDESLSSISSAIPANMTPDDYIRHRMSDMTVSQPQLRQHVSGPSPLEPNSHQSFYESFSRRGSITDPASFHSTSRRPSIAEVLPLPNSAVQSRRGSVATDYDCPSRSPSPSAFTRQRLYDNQDGLPYSFGRRYSLSNGANNANNGSKHPLAPPPPNTGSFYDPFQRRHSIATAETSYSSTSRYGPAGGNNTSASKYKAFKFPSTIPELPTYDTFSAPPSPSRLVNTGRPEFMQDKAATSRYSHSSQLMDNHHGGPISLSSQRRKASLVEDYRATEPYTPVRRASMPLVTVRSAGSLPQLSEEDINGNGIDLLASDRERPRKETPYSRSPALRISHKLAERKRRKEMKCLFDELRDSLPVEKNMKTSKWEILSKAVEYISLLKRRDYDLENEINELRREIDAIKRERTSNYAPPYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLM0</accession>
    <name>A0A367JLM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_006889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01001061">
        <property type="protein sequence ID" value="RCH90828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLM0"/>
    <dbReference type="STRING" id="86630.A0A367JLM0"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH90828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="189" mass="22170" checksum="3BA16D83517039FF" modified="2018-11-07" version="1">MESVQIDPQTGKEIPMKDGKPCRVCVDFKTWSKLEKTKIKTEKTSNVKEQESEKSNAEARPIDNKPQKVTEEWKQNNCPADVETLGRHTWTLLHTMAAYYPERPSPSQQESMKMFMKTFSENYPCWFCKNDFQKDIETDPINVKNRETLSQWLCRRHNKVNEKLGKKQFDCSKVFERWLTGPPSGECDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMV6</accession>
    <name>A0A367JMV6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn finger-containing GTPase-Activating Protein for ARF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GCS1_4</name>
        <name evidence="7" type="ORF">CU097_012487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001002">
        <property type="protein sequence ID" value="RCH91225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMV6"/>
    <dbReference type="STRING" id="86630.A0A367JMV6"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="153" mass="17722" checksum="95B5827428AE2314" modified="2018-11-07" version="1">MDYKQTLFEIQKRPGNRLCFDCSAPNPQWASVSYGIFICLNCSGVHRSFGVHISFVRSITMDKWFDDQLKKMDIGGNEKAKEFFESQPEYSTNMTTTQKYHSRFATAYRQKLSTEATDRPANITKQRLTTTFTKNNVNDEEDFFAATIRSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JND4</accession>
    <name>A0A367JND4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000970">
        <property type="protein sequence ID" value="RCH91436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JND4"/>
    <dbReference type="STRING" id="86630.A0A367JND4"/>
    <dbReference type="OrthoDB" id="2231177at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14067" checksum="1CE4BE72480339CD" modified="2018-11-07" version="1">MTRSLSQGLQNSLRSLLSESDMSFDEIAQRLYVSKSTVSRYCNSWGIARPDNLGGRPSILSKTSKALMKRMVLNGELKTAKQVHRHFVNLYPKLTYYTILNALKSMDFKTSSQRKHLFYARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPF1</accession>
    <name>A0A367JPF1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KRS1</name>
        <name evidence="14" type="ORF">CU097_010827</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000915">
        <property type="protein sequence ID" value="RCH91822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPF1"/>
    <dbReference type="STRING" id="86630.A0A367JPF1"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="237"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH91822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="572" mass="65348" checksum="E1CC9970205F7FC6" modified="2018-11-07" version="1">MSEPVDQKNLQKDPVTGEMISKSEFKRREKLRAKEAAKAAKAAAAPAKEATPKEKSAEEGEEELNPNQYFELRSKVVNKLRDELNPNPYPHKFQVTLSLPEFIEKYSKLEVGERLDDQVISVAGRIHNKRASGAKLRFYDLHGDGVKIQVMASLQDNEGDDYAHIHDLLRRGDIIGITGVPGKTKRGELSIFPKKVQLLSPCLRMLPKANYGFKDLELRYRQRYLDLIMNGFVRDKFYIRAKAITYLRSFLDQRGFLEVETPMMNRIAGGATAKPFVTHHNDLKLDMYMRVAPELYLKMLVVGGLDRVYEIGRQFRNESIDMTHNPEFTSCEFYMAYADMYDLMDMTEELVSGLVKSIFGKYQIEYHPHGPEGPVMNIDFSPPFKRIDMIQTLEEKLNVKFPPGDQLHTAEANKFLSDLCIKNKIDCSEPRTNARLLDKLVGEYLEVDCISPTFITGHPQMMSPLAKKHRDRAGLCERFELFVATKELCNAYTELNDPFDQRERFAQQAQDKEAGDDEAQLIDESFCQALEFGLPPTGGWGMGIDRLAMFLTNSNNIKEVLLFPAMKPEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQM4</accession>
    <name>A0A367JQM4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_011836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000855">
        <property type="protein sequence ID" value="RCH92252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQM4"/>
    <dbReference type="STRING" id="86630.A0A367JQM4"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="353" mass="39913" checksum="2942D30443AFA82B" modified="2018-11-07" version="1">MPHHQHNPFVKKVLALFKKTHEGEKSQYPTELTKKYKIGEKQLGVGSFAVVKECVNLSTGEHCAVKIILKKVIAGKQNMLDSELDILKKVRHSHVVSLHDIYESDDAVYIITDLCTGGELFQRIVERGTYTESTAADLVRQLLEGLAYLHSMDIVHRDIKPENLLFKTPDEDAELLITDFGLSKLLKDHDQVLTTACGTPGYVAPEVLLGTGHGKPVDLWSVGVIMYTLLSGYTPFYGEDQNELFSAIMSGRYEFDDEYWSEISAEAKNLIDRLLTFDPKDRITAEEALEHPWIMNKEEYGFNLAPTVRKGFNNRRTLQSLITVVAAINKMRIHHPLADLEIGDDEDEADREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQQ7</accession>
    <name>A0A367JQQ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin type-2 heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MYO2_2</name>
        <name evidence="12" type="ORF">CU097_000638</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000850">
        <property type="protein sequence ID" value="RCH92284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JQQ7"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="81"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH92284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1589" mass="183207" checksum="FA93A560F3E4B465" modified="2018-11-07" version="1">MSEKQDFIEVYTKGIKAWFPDKEEGWVSATCVSNTVEGDKITLKFIDDSAEKEHVFESTLTAIKKSNGSNLPPLRNPPKMEYTDDLTNLSYLNEPSVLNTIRTRYMQHLIYTYSGIVLIAVNPFDRVPLYESDIVQQYSGKRRGELEPHLFAIAEEAYRCMIREQRNQTIVVSGESGAGKTVSAKYIMRYFATADDQESTGKVKKDSGSLTEVEEQILATNPIMEAFGNAKTTRNDNSSRFGKYIEIQFDGCANIVGAKIRTYLLERSRLIFQPETERNYHIFYQLCAGVPSQERKEFELNDYTHFHYLNQSGTGEIPGVDDKQEFDLTQKALSTVGLSVDLQWKIFRLLSALLHIGNINITGRNDALLSDTDPALATSSRLLGINADEFRKWIVKKQIITRSEKIVTNLTPVQANVVRDSVAKYIYSNLFDWLVGVINESLSCPDEQNTVKNFIGVLDIYGFEHFKQNSFEQFCINYANEKLQQQFNQHVFKLEQEEYMREKINWTFIEFSDNQKCIEMIEGRLGILSLLDEESRLPAGTDQAFCQKLYDHFATSEYKNYFKKPRFSNQAFTIEHYAHEVQYEAENFLEKNKDSLPDEHLEMLRNSEFNFLEEILSKSLSAAQAMASTDNKRKSMISRKPTLGSIFKNSLINLMATIGNTNVHYIRCIKPNEAKVAWEFDGPMVLSQLRACGVLETIRISCLGYPSRWTFEEFAERYYALVPSKQWETNDIRSLCQLVLDSCIKDTDKYQIGETKIFFRAGQLAYMEKLRSDRYDACAIVLQKNMRRFVYRRRYVRLQALIVQLQCLARQKLATHKLQKLRQNKAAIIIQTNFRRYIAHKSFVSKKDFIIRLQTAIRSRQTRKIHKSLQEHHAAIQIQRHARGMLARKWYKSQIAHIVLLQSCIRRRTAQKQLVTLRLEAKSANHFKEVSYKLENKVVELNQMIATLKAEKTASDQKAVHLEAQLQHTTERYEKMEKSSKEVEHSLKELKTSYELLQEEHDKVKSEHASTLEKVQKLTKETNVLKEQLEKEKMKLQQQKEKAKPTKDENASEVAELKQQITALKAQLARAMHSTRKQDSLSPARNGNRTLSPSPMRGRQPSFSAEEPLKQTTLLTNRKTRRNSSIEVGAVGAKSSIDRIRLAEELSNGKTPRPTSLGLYGINSQAGRLNTISGDPEEEINSILRQEEPLQEEILSGLVRSLKIPLPSTKNPPSLKEIVFPAHIIGLCVKGMWRIGYHRESENLVFAVIDAIHKQCLAFNGEDAFVPCSFWLTNTHELLSTIIQTEQQFQKELQERGHSISWRELEKLTQDIKHELQCLEDNIYQILVKEIKKQYSKMVIPAVIESQSLPGFITNDSGRFLNRLFMTHSEPAYNMDDLLAFLHKVYKTMTCYSIEPSAIRQVLTEVLKMTGTMSFNDLLMRKNFSSWKRAMQIQYNISRIEEWCKKHDIPEGVLQLEHLTQATKLLQLKKASLEDIENIYDVCWVLSPTQIQKLISQYHLLDYETPIKPEILKEVANRVISGGNNVLLLDLVPLDTSAPFEIPSSRKVTEYLYLPAWMQLKRLRQLIQLEAALYETKRNEVIVEEPGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR70</accession>
    <name>A0A367JR70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000831">
        <property type="protein sequence ID" value="RCH92418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR70"/>
    <dbReference type="STRING" id="86630.A0A367JR70"/>
    <dbReference type="OrthoDB" id="2250876at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20684" checksum="CE7893A78B7A975F" modified="2018-11-07" version="1">MKKLKQMFTELKVSKTTLFDFVKQHCNLSLKKARLQPIDRDNEEKIQEHLDWVLDEMDLYPHMKGHYLMDNAPIHTSEDIAKYIESRDGEKFPLNDDKTCFLSLRNELIIFSLLARDDGNGHDDISDEELEPQQMMVSTATLIYDYPHVIENDWSAIKEAKRDYDHAVLHACRVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRC1</accession>
    <name>A0A367JRC1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar transporter chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VTC4_11</name>
        <name evidence="8" type="ORF">CU097_011849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000857">
        <property type="protein sequence ID" value="RCH92241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRC1"/>
    <dbReference type="STRING" id="86630.A0A367JRC1"/>
    <dbReference type="OrthoDB" id="2278074at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="525" mass="61561" checksum="7F526A0D497E8B40" modified="2018-11-07" version="1">MFILKKHDKWTEFTLAHKYNRYWDNYITMLQDKLDIVYHLRTFWVHKDHLNELEAILLFRSPKQEIDPVQFVYYDQLPSFQVYMDFLKKKEPTELIKMIWIESQLVKSYLEGEPMQFSCDEDSRTASAIRETIQSKSLKPIIKGSYKSTKYSDQGITLLLKKNLVFMKEQHESSGTLHDESYYFPYALLEIKSAAHQEMPDWLIHLTNVSRLVYEVPYFIDYAQGAADCYSDQLQLLPWWLPELIKDIYKAPGQDDAIFLEEKDVHANSSMTVLEITRDDQNTYNKFMSSAIVTKIKNLPPMFKDNRDNQDDMTMIKWLVAKVTNNKQLLEPTKEDPRIMPKNGKVKKLEPKIFFANERTFISWLQFSAFLLTMSLALINFGDHVSRTSGGIFIMVAVILAGYALLRFQYRAWQIRFRSSSRFDDMYGPAIICFVFVLALLVNFGLRVSQPVTNNPSPFGKSYNVSNTQYNMTHPTNNDNKHNHPIKDEDGLDNKDHHRLQEANRNNTTRLTKHGKIKEEDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRN8</accession>
    <name>A0A367JRN8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_005228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000802">
        <property type="protein sequence ID" value="RCH92622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRN8"/>
    <dbReference type="STRING" id="86630.A0A367JRN8"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="57884" checksum="98196A0CAB05FF9D" modified="2018-11-07" version="1">MPRLPFISRRANQSPFYGPDDDIPILVTILMGIQHFLAVIGGIITPTIIISGQGSSNLNLDEDTRRYMISASLIVSGLMSLVQIIRIRIPKTRFYIGAGLLQITGVAFCNVPAAQALIQNMYKSGECPTETLPDGTISYLPCPDAFGAVLGTQMLCALLSIAISFLSPRVIRKLFPKVVTGIVLVVIGATLLTSGMENWAGGSGPCMSRPNSGPFTLCPSASSPNAQPWGGPVNFALGASVFFTIIVIELVGSVFLKNISVVIGLIIGCIIAASVGMFDSSGIVSAPVGTFLWVKHFKWALHGPGVIPFLFVQLNMIIECLGDLTAACDVSGLPIEGSAFEERCQGGLLADGISGIFSGLATSMGVVTFSQNNGVIAVTRCANRRSGAVCAFLLIICGVFSKIAAAFLAIPSPLIGGMTVFLFASVATSGVRILGYLDWTRRDRVIVASSLAIALGVSLVPDWFTYVLPSSENLALQGFLSAITTVVSTGYIMAGIMSIILNLILPYDSTEQEDQMARQTKLNGGVALLYSESASKNRNNSCQDEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUB1</accession>
    <name>A0A367JUB1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000688">
        <property type="protein sequence ID" value="RCH93517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUB1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="105" mass="12360" checksum="7AF0657537A8B0E9" modified="2018-11-07" version="1" fragment="single">MSTFIFAPSWADYSNRPKNIDEFPTLIQNNSKQSYQQNNAWSSSYLLQKIQRPEDIEDIKQDELKEDKKTELERLKALVPKRINHSKNNMIATRPMKTRLYASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUY5</accession>
    <name>A0A367JUY5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SPT4_1</name>
        <name evidence="15" type="synonym">SPT4_2</name>
        <name evidence="14" type="ORF">CU097_011042</name>
        <name evidence="15" type="ORF">CU097_012314</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000659">
        <property type="protein sequence ID" value="RCH93753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000140">
        <property type="protein sequence ID" value="RCH99192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUY5"/>
    <dbReference type="STRING" id="86630.A0A367JUY5"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH93753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH99192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="116" mass="13337" checksum="E4E674307D078E44" modified="2018-11-07" version="1">MSQVLPIDKKQLRACLLCSLIKNASQFRANGCENCDEILQMRGSMDRVIECTSSKFEGFIAMMNPKESWVGRWQRIDKFTRGLYAIRVYGRIPEDVEDDLARRGIPYKPRDGSMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV23</accession>
    <name>A0A367JV23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA mismatch repair ATPase msh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MSH1_2</name>
        <name evidence="11" type="ORF">CU097_013081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000687">
        <property type="protein sequence ID" value="RCH93521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV23"/>
    <dbReference type="STRING" id="86630.A0A367JV23"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="9">
        <location>
            <begin position="322"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="653"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="847" mass="96157" checksum="9228404E2F42EFEA" modified="2018-11-07" version="1">MKLSELVQKGDLSTKSLDKKEISTGSIVLDTVREYTKKYPLCVLLVQVGDFYELYESHATRYAPQLDLKLTRKAITANTVVDFAGFPLRSLDRYLDILVNRLQCRVALCEQLGAASRDDRSIMGMHRRITRIITPGTVIEERFLEANQYNYLLSIFPSTQDKLGLAWVDISVGEFVMQETTLDALKDDLARIRPREVVLPESLKPSDEVLQQGLFDLDVYDPVTRLLVSDPSITVSYQMDDHFNASAGFKAFQALFTKFAETSDFGQLELGAAMALMAYVNETHVDKTIKWQMPTRFSIHDTVRIDSAAMSSLELVKTLQGRRNDSLLSILDCTCTSAGSRLLNRWISSPLTNVNEIKKRLDVVEYFSRDPFLLQDVRHLLRQSTDAQRALQRLALKRGQHSDVFEVWSALDIIKNITGKLKNAEAPALRELVEYMDPHMTISQHIQDAFDYEKIQSKEIKEYGFVNHAFHPELAQLHNEITELEQQRANLQDDLRELCGNSVTLQSDGLFRHIVEVSTRQSSHLLKRFPQAQLVSSTKSKNRYQIEAWSDISIRLSTIQSRIIEIENQVFDQVVDRLLDHSTTILHSCRILAQLDVLASFSHLALERQYVRPRVTKTNRTMIIGGRHPVVEANLAKKGISFVANDCILDRDERIWLLTGPNMGGKSTFLRQYAIIVLMAHIGCFVPADRAWIGVTDRIFSRVGAADNLAQNQSTFMVEMSEVSTILKLATEKSTVIMDEVGRGTSTAEGFSLALGILDYLHNSIKCRTLYATHYHELADAVKEYEHIKCYMTNIEEDHLGRFRFVHKVQPGVCRQSHGLKVAQLAGLPTEVIDKAKAVWNQMKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV85</accession>
    <name>A0A367JV85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">6PGD_3</name>
        <name evidence="12" type="ORF">CU097_008852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01000657">
        <property type="protein sequence ID" value="RCH93769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV85"/>
    <dbReference type="STRING" id="86630.A0A367JV85"/>
    <dbReference type="OrthoDB" id="2329895at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1460.10">
        <property type="entry name" value="Nuclease A inhibitor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="351"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH93769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="654" mass="72647" checksum="BC3DD57E2B136DD6" modified="2018-11-07" version="1">MTDNNDGEDAYMQMLNNPMINPPHSTKPQMTKESKLKPASFPIVQEARDLLTSAAKNIYLESESDEPFEWINTKTTKTTLPTSIDELDDLDLLNGNEENHLEIKSYHEFLQDERYRPIKESLDKLKEKVDQESKVYLVGRNSITVLILTIVHHEQEHAIVGLKSLLYLFDTYVSADVGLIGLAVMGQNLILNMNDHGFVVCAYNRTTSKVDHFLENEAKGTKVVGAHSVEEFCSKLKRPRKIILLVKAGSAVDNFIEQLLPHLEQGDIVIDGGNSHFPDSIRRCKELEDKGILFVGSGVSGGEEGARYGPSLMPGGNPKAWEHIKPIFQAIAAKAPDGAPCCDWVGESGAGHYVKMVHNGIEYGDMQLITEVYHIMKEVLHLTEDEMADVFETWNKGDLDSFLIEITRDILRYKDQDGKALVEKIRDTAGQKGTGKWTGIDSLDRGIPVTLIGEAVYARCLSSLKDERVRASKILKGPTQGQFTGDKKKLLDALGQALYASKIVSYAQGFMLMRQAGADYGWNLNFAGIALMWRGGCIIRSVFLGKIKDAFTNNPRLENLLFDPFFQEATAKAQDAWRQVIATAVQAGIPTPALSTALNFYDGLRHEKLPANLIQAQRDYFGAHTYELLDNPGTYIHTNWTGKGGSVSASSYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVT7</accession>
    <name>A0A367JVT7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SWIRM-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_009164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMARCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000624">
        <property type="protein sequence ID" value="RCH94053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVT7"/>
    <dbReference type="STRING" id="86630.A0A367JVT7"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="284"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="63633" checksum="D36446B0096D4098" modified="2018-11-07" version="1">MSTSKKPRLDKDNTTRPFIPVQQYEVIIPSYAAWFDLSTIHINEIRGLPEFFNNKNKSKTPSIYKEYRDFMVNTYRLNPLEYLTVTACRRNMTGDVCAIIRIHGFLEQWGLINYQMDPTAKPTAIGPPFSGQIKIIAEIPKDLQPALSSENQQSTDETTADATIETNMATDKDALEETVKTPKPEKKIKTEEPEHIKTEEASSIKQEISLNLDLREDIFNTAKKRHVQKKTIKTCECCKKSQNIYEGYRHESMFVCSECFEASKLPEGTKKEDYDKEMKHEEEPLEDTWTEQEDLLLLEGLEMFPTDWNKIAEHVSSKTREACVLRYLKLPTADPRIDPDIKHRGLLDFDAKDKIDNPIMSVVAFLASNVKPEVASSTIHERQDNDAEMKEKEEEDNQQLRADLLHSKVSLFSARLRQFREKEKLIDLERREVEYEKWRAQEDLCFLKNRIDSIYARMFHASQAKIAAQQQQQEEQMPENVIVYLLDDPTLTEEQRKEQLELKQRYPKQYESRQILLQQQQQQQQQQQQQQQQFQQQSNGIQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW68</accession>
    <name>A0A367JW68_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000642">
        <property type="protein sequence ID" value="RCH93901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW68"/>
    <dbReference type="STRING" id="86630.A0A367JW68"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="171" mass="18934" checksum="15EA5BE43038024C" modified="2018-11-07" version="1">MLDRLPFQFQSYFYSMSAENPQVSAQSRAEQKARKSLLSLGLKPVNGITRVTFTRGRGIVFAINRPEVFKSVNSDTHIVFGEMSVDDMAARAQQAALEQQLAAEGEKTEEKPAEEAQAAVEEEEEEVDAEGVEEKDIELVVNQANVSRAKAIKALKNNDNDVVNAIMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX05</accession>
    <name>A0A367JX05_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000578">
        <property type="protein sequence ID" value="RCH94438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX05"/>
    <dbReference type="OrthoDB" id="2220024at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="117" mass="13124" checksum="55B1D0EAA460BBFE" modified="2018-11-07" version="1">MTSKATQEYRHSFITLISQLSEIEQRGQEFFDKIESSVFIPHEPSVIQADFEHLINMISSLETHAKSTGLLSISGQPDIARNLATRNAETLQAVDTFFQEKSRLLTNIRAAVNATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX89</accession>
    <name>A0A367JX89_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000570">
        <property type="protein sequence ID" value="RCH94517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX89"/>
    <dbReference type="STRING" id="86630.A0A367JX89"/>
    <dbReference type="OrthoDB" id="10290676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="66051" checksum="31BC1963306BC645" modified="2018-11-07" version="1">MSSPVDTPYWTPIQRCMPALEEKHTIIKDNSTKKSINKAGICLKEESNESIGKDKTAVNSLNSNSSDSLADHTSSSPTKPLTVYELNQQADTTKLETQVIIMDPTIEDDQMVDPIKLGPIPEQDIEQTAEFVVDFDKIDGRTLRVEHESSGPSITDSTSSSSMNTSSSNNSSNKDSLDPYKAVASDIEQRWPVPKTIEEMYTLYEQEKAKGDPRSQLALCLHLLQCASKMNPENNIVVPHDMNITTPNPGTARRQLLDGIMATLRQHSQSNPNLGQLMVKEAKQILKQLATSGQSAGQAGDAEAQFLLGSCYGMGALGWPMNHEQAFAWYLQASKQRHPEATYRVGVCYELGLGTARDGGRAVTFYKKAAHLAHVPSMYKLGVIYMRGYCGQPVIKRDAIIWLQRAAAQSDTMTVDNEMALPEALHALAIIHLNKECQDTSIIPDTEYAIKLLHDAANLGYAPSQFKLGECYETGSHVVEDEAQSIHWYTLAAKQDYAEAALALSGWYLTGSIKSKVLPQSDIAAYTWARKAAVLAKRAQLKPVAADAYYSLGIFYENGIGVRQSAEKSMKWFRRAAHLGHPECLKMLKSSNEDVKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXQ9</accession>
    <name>A0A367JXQ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000578">
        <property type="protein sequence ID" value="RCH94441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXQ9"/>
    <dbReference type="STRING" id="86630.A0A367JXQ9"/>
    <dbReference type="OrthoDB" id="2282358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15311" checksum="C5037CBED85BC573" modified="2018-11-07" version="1">MKLLMEHPRSSKSQISGLLLDQEKAYNKVHPDYLRQMLYCFGFSLSIIRSLATLFFTIYLMLNINGFFSQHQGLRLKEDPRRNVKKFARFQVEDKARMKNHVPRSKFDEKWLGPMDVLGRIAYWALSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY76</accession>
    <name>A0A367JY76_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NIP7</name>
        <name evidence="9" type="ORF">CU097_014277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000534">
        <property type="protein sequence ID" value="RCH94845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY76"/>
    <dbReference type="STRING" id="86630.A0A367JY76"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="180" mass="20497" checksum="CF756C908AFABAF9" modified="2018-11-07" version="1">MRPLTSEETTTLFEKLAKYIGSNIKHLIDRPDETYCFRLQKNKVYYVSESMVRMAVSVGRDQLASVGTCFGKFTKTGKFKLHITALDYLAQYAKYKIWIKPNGEMPFLYGNHIVKAHLGRITDDTPEHTGVVIFSMSDSPLGFGVTARSTVDMKKLQPTDIIVFHQADVGEYLRDEDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYH8</accession>
    <name>A0A367JYH8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar transporter chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VTC4_10</name>
        <name evidence="9" type="ORF">CU097_011772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000520">
        <property type="protein sequence ID" value="RCH94957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYH8"/>
    <dbReference type="STRING" id="86630.A0A367JYH8"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="752" mass="88124" checksum="06DD742FA0D5137D" modified="2018-11-07" version="1">MKFSAEFNARIKEPWRDSYMEYASLNNLLKAKTTDEWDEQCESEFNACFLTELEKVYCFVQIHLDGLVKRINNFDKILERKNDFMMNIKYEAIADDIAETLVDVDELAKFHSLNVEAFERIVKRHAQYAEHIQQAFNFENALAIYPLYNQRFDPLLVLLSEMYTLCKRKGEPEVMDKVADEPDQVEFERETKKYWVHPDHITEVKAIILLHLPVHVQSQGESYKATDAAVSSVYYDNKSFDMYKQKLIQKKGSEIVRVRWYGNCDSLNDDVYVEKKTHRAERLEGKSVKGRIKIKGQQVNDVMNGRYNMEEYEDEMKKKGTLDKEIIERRLFIAKGIQSLVMNRKLQPICRIFYNRLAFQLPDDQRLRICLDSNLTFIREDHLDGKQRRLQDSWRRADVDIDYPFHSVDENDILRFPYAILEVKVQNHLGQEIPSWLSRLLNSDILHEVPNFSKYLHGVSHFFKGIVNELPPWLSQLDQNIRKPAGSRDGITRSQSFKALFNGRHRRSLMQNDEKNNNGSLKIQVEESLFKERLESINWGFDNTNKRGRLDAPISSRVLINRENRIHGQLVDIPEKTELTDEPDIASRQTFVSRMVQRYKERRKKEKNDEENPSSAGPSAPVRTMTRYSSFHPARQDPKVFFANERTFLTWLQFCAVLLTIALKLLNTGDGITRIVGTVFLSLSAFLSMYALIRFHFRAFRLQTGRTDLRLDDIYGPGVLCVLLVTALAFNFYVRIPLLFSEERTRILPNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ27</accession>
    <name>A0A367JZ27_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Amino-acid transporter arg-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_012991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000496">
        <property type="protein sequence ID" value="RCH95157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ27"/>
    <dbReference type="STRING" id="86630.A0A367JZ27"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="256"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH95157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38231" checksum="986F337B9A3490B8" modified="2018-11-07" version="1">MEEKQSATHNVILLKENNLFIPKIEQKSNLRKQIDDLIFGSIAGMVGKFVEYPFDTIKVRLQTQPVNKPFYSGPWDCFKSTMKQEGIRGLFTGMSSPLVGSMIENAALFVGYRQIQRLIREYSLNAEELDKLNNIPEEDLPPLKMSQLVLAGAASGAIASFILTPVELIKCKLQVQIGINASASTHQFTGPFHVIQHVVRTHGISGFYRGFLATLLRESGGGAFWFGTYEFACAQFIKRRQAVTDEAFLKKDLSPSELMVSGALGGMAYNLSLFPVDVIKSQMQTDEQLLASSGQRSFTQTAKELYSTGGYKAFYRGCGITVARSAPTSAIIFLTYELLNRQFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ62</accession>
    <name>A0A367JZ62_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SWIRM-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_002316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000490">
        <property type="protein sequence ID" value="RCH95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ62"/>
    <dbReference type="STRING" id="86630.A0A367JZ62"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="275"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63783" checksum="AED09A0C8BD10841" modified="2018-11-07" version="1">MEQQQSTSMDINSPKDNIKKEAHPSEAENNVNNEQSTTKTEPLTTTRSVIEVEARKYLMEQTKPVKVPSYASWFDFNSIHPIERVALPEFFTNNNSSKTPTIYQDYRDFMINTYRLNPKEYLTVTACRRSLAGDVCAIMRVHAFLEQWGLINCECDPFTWPSSIGPPYTGHFRVTADTPRGLAPYKPNIKPSTSSAPKGELNIELRQKVFEAANGASTRECFCITCGAECSRERYHSLKIKNMDLCPLCYKEGRFPASCFSSDFIHYSRQQEKQEKSEKWSDEETLLLLEAIELYDDDWNTIADYVGTKTREQCIYHFLQLPIEDPYRSIDGNVHSSVVDHKRIPFSQADNPVMSILAFLASTVDPEVASTAAKAAIACQEQQKRKNEDDMELDKEQPNKKPRTLIEKAASVALGSAAAKAKSLSSIEEREIRRLVHSVLEAEIKKVELKMNYFDEMEAVLEYEMEALAQQRKDVFTYRLSVKKTEALLEQEINKRGGVEMAIENGWAPQELQQLIHNSLFKEDYHLVDMSTLDESTLVHPSTRMDESESAKDAPSVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZW9</accession>
    <name>A0A367JZW9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000461">
        <property type="protein sequence ID" value="RCH95493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZW9"/>
    <dbReference type="STRING" id="86630.A0A367JZW9"/>
    <dbReference type="OrthoDB" id="2418125at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="243" mass="28048" checksum="C36BCCFADFC6AAFC" modified="2018-11-07" version="1">MHKKSNVQDKRSVSLRPDVDSDDEIDQEVQEEAQKMDALMRQLLGKGEQEQVDNEQLEQDTAAEEEFSFRLFAHQPLAKVAIAEDTKDDGQAQAVADMQQLEFDEHDPELMARVKEAAIDYKDILRQSTVPYPAMQFPHRVININSVNKSITEKSKRKRKSKKCRDFEKKVKAGEIKVQPNMRNPDTPGGWPGWPGQLTRVSIINYISPRRKEKSFNKPRPMNKSFSRGGAKPQFHLKRQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0B6</accession>
    <name>A0A367K0B6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000451">
        <property type="protein sequence ID" value="RCH95585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0B6"/>
    <dbReference type="STRING" id="86630.A0A367K0B6"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF52">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="69386" checksum="EE8F3C0BA924B75B" modified="2018-11-07" version="1">MGQHTSREHAPLTFGYINDPSRLNKQKESISEEGTSEEQKDPVLTNPHLYRLQAICEQCHQDKDKEQMIVSVLGEPCSTCQGQKRLSLVRRGLAEDLEYIDQTYYPDLVHYNNTINDPMETELLELDDEPNRQWSRLTIGDVTPTRRRQRRLTGPSMSVDLSDRRLVKLSPTIGYLDNLTKLNLSNNQMTELPKEVGYLKNLTVLNISENKLVELPDTIAFLSKLKALNVSHNQLSTLPPSIGQLRKLVIIIANNNQLAHLPKEISELSKLVSLNLSFNPLKSLPAEIATLTTLRKLLTEECPFEDEYTYDLPHDPPSLLETCARIAVKHEIDIPNHLASHIKDYLARASKCSYCHGPYFDNYITRFRFIERTARHTVALEYKLCSAHWSNDNDRLLAMFSHSSHNSRDHDVDTEGLNEEVHMTRRNRAYSDSSSLTGYLTPPFISTPNSEQSVDYFSLPSSSLSTTPISRLKSKPSLPALPAQKEYRNRPRASSSASVTKRFTNFIRSNSSTSIKQRERSQSGSCLQEGGSSNSSTSSSSNPSLAALDDNNEILPFHRRQLHTKKGLREWTDNIQMATAAATSTILSDNPPDNDNEQITPIIRNNSIATIVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1S0</accession>
    <name>A0A367K1S0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000400">
        <property type="protein sequence ID" value="RCH96118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1S0"/>
    <dbReference type="OrthoDB" id="2289295at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="23115" checksum="632870CE22B18E94" modified="2018-11-07" version="1">MQRKLYCKNYVKAMYKDLIWREQLWEEIFNLDHVQRRRSRAQDTSKSTSLCFDYDFETDGHMISLDVVNRFHPGQSTPSTHLMNLTKPTGLFLNDRTIGIDPGHRDLVTYVNTDSELTTKALRKVYSFSISNVQYQEQCGFKWITQVELKSRKNVVDIQAIYDLIPLPKVFCRFKFMEYLSVISATRNSIFNFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1Y4</accession>
    <name>A0A367K1Y4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000393">
        <property type="protein sequence ID" value="RCH96186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1Y4"/>
    <dbReference type="STRING" id="86630.A0A367K1Y4"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24556" checksum="A3B8D6FB37DB8DF5" modified="2018-11-07" version="1">MLPEQSQSRNSRHNSLVLSSDQQFQHVHHPFGIMPDDAIVTERDPLIIPPPTVWTRFNEKHRFGKLILVAAGCLGIIIVMLSVLGGLGVYKNTRYRNQVGVSSIGKTRYKGDSWGTAKPGEFTMGGQGDATYYDPGVGYTSCGNLFTASDMVVALDGYDYGSYADPNQSPVCGACIIITGPLGSTKATIQDMCPSASCGRGSLDLSPAVFAKVGDFFDGRIPVNWTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2K0</accession>
    <name>A0A367K2K0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000373">
        <property type="protein sequence ID" value="RCH96390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2K0"/>
    <dbReference type="OrthoDB" id="2270049at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="17175" checksum="49CD38A4DD7EFAB8" modified="2018-11-07" version="1">MTNFYWYSTNGMAQHRLPSRHFAVLDQAFERHTRIQIYDDEIFGANVPALANPYQGTMTAGDLHFGLYRHPPIWRMSDVSLDTLTFIGDSNFTDEDKSTRRDSHGNMIQDKEMAANDNTETRNLKYRTKQRRRMMIEDDCINCCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2K5</accession>
    <name>A0A367K2K5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="primary">HIS7_1</name>
        <name evidence="17" type="ORF">CU097_012985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000368">
        <property type="protein sequence ID" value="RCH96444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2K5"/>
    <dbReference type="STRING" id="86630.A0A367K2K5"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="393"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="465"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="491"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="514"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH96444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="60017" checksum="84854B696FB916F3" modified="2018-11-07" version="1">MLDYGAGNVRSLVNAVHHLGFDIQFVEEPSDIAKADKLIFPGVGDFGYAMRALRNKGYSQPLKDYIASGKPFMGICVGMQSLFEGSDESDEPGLGIIPGKVSKFDATSKAVPHMGWSNVQVIKEQTKDEGQEVNYSMNDDKAYYFVHSYAARYTEKNKEWTLTTSQYGDELFISSVQKDNVFATQYHPEKSGYAGLNVLKSFLTGTGIVDNKHIISKEPVLYEKHRLTKRIIACLDVRANDQGDLVVTKGDQYDVRETGGNNDVRNLGKPVDLAKRYFEEGADEVTFLNITSFRNCPLGDTPMLEVLKRTSETVFVPLTIGGGIRDVTDPDGTFHPAFKVAGEYFRSGADKVSIGSDAVYCAEKFYENGCKKTGTTAIETIADAYGSQAVVISVDPRRVYVKDPSETTHHVVKNSQPGPNGEEYCWYQCTVKGGREGRDLDVVQLVTACEKLGAGEILLNCMDRDGTNSGFELELIRAVKEAVSIPVIASSGAGCVEHFEQVFEKTDVEAALAAGIFHRKEVPIQSVKDHLKKTNVAVRPVDTTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2W8</accession>
    <name>A0A367K2W8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MPK1_4</name>
        <name evidence="11" type="synonym">MPK1_2</name>
        <name evidence="11" type="ORF">CU097_007978</name>
        <name evidence="12" type="ORF">CU097_014339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001441">
        <property type="protein sequence ID" value="RCH88584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000355">
        <property type="protein sequence ID" value="RCH96592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2W8"/>
    <dbReference type="STRING" id="86630.A0A367K2W8"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH96592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="430" mass="49049" checksum="5ED56D9104022339" modified="2018-11-07" version="1">MTNYQAFPVLNQQFIVDKKYQFIREMGQGAYGVVCAAKDTSTGEQVAIKKVCRIFEKTILAKRALREVKLLKFFNGHENITSVLDMDIVNLQDFNEIYLVQELMEADLHQIIRSGQPLTDAHFQYFVYQICRGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGYSDNPDYNAGFMTEYVATRWYRAPEIMLSFQSYTKAIDMWSVGCIFAEMLGGRPLFKGRDYVDQLNQILGILGTPDEETLRRVGSERAQVYIRSLPRMPRIPFENLYPRANPLAIDLLNKLLEFDPSKRITVEEALAHPYLSAYHDEDDEPVHTQTFDFSFEVVDSIEEMSRMIAQEVMTYKASKQQSLQPIANTGANLRRRESMSAQDRETLAAAQARATQEADNTDSGVAGVAETAVHHRPIRDMEVDELERELSGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K342</accession>
    <name>A0A367K342_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000381">
        <property type="protein sequence ID" value="RCH96301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K342"/>
    <dbReference type="STRING" id="86630.A0A367K342"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="9"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="357" mass="42067" checksum="901007E9DF1DB6B4" modified="2018-11-07" version="1">MAPRSRKHTVSHFNVMVVGHSGVGKTSFIRTLLETLRLEEKQRKEETPTTKKRRDSFMSETSFVNIEPEGPIEKTLQPYTVSREINIDREHVLLTLIDTPGFHQEYLIDKQLHDILKYIEHQFDLTLAEETKVKRNPKAVDTQVHCCLYFMDPKKSCLDEYDIRILTRLSNRVNVIPVIGKADQLTLAQKNRLKPRIIQDIYNKIPIYGMPTKEEEEEDEEDEETKKAETLNDFIQQFNYEEEDQDTKTILDYLKIIPFTFIAYEDEPDTGKPLEIEGLSLGRDFGWGTIDCLNDKYSDFNQLKHALLFTHRKFLQLDTVERYYEQYRTEKLMFKRATRLKSLDMSSQKILKDLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3H8</accession>
    <name>A0A367K3H8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000342">
        <property type="protein sequence ID" value="RCH96720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3H8"/>
    <dbReference type="OrthoDB" id="10566792at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="184" mass="21726" checksum="83DFF6FAB5DB35E1" modified="2018-11-07" version="1" fragment="single">MTAYTLLEQPLSRRISKRQCQIVALLFTSLLFLLFFFFKTTQEETLPYDKTYPPIRYINFTVPGQDDLVYVDLDRYPIEDQIIQLFAGSKEVIQEYTINKIQKKKQSPWVKTPSRIQPDTYACKNQLPPYPILRRIVKDHLDIADTNVFFEDDVELNLSLPFVFLPFEKQPKLKKGYHVCIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3L9</accession>
    <name>A0A367K3L9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_013476</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000341">
        <property type="protein sequence ID" value="RCH96739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3L9"/>
    <dbReference type="STRING" id="86630.A0A367K3L9"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000009">
        <property type="entry name" value="Oligopeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="11">
        <location>
            <begin position="96"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="293"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH96739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="763" mass="87197" checksum="37B2E6E0359AACF3" modified="2018-11-07" version="1">MYRLLRQSKRVPNYRLACRSISSVKHIRPIIKPLVQPSSAALQQLQRNRMVFINTKRHATTTASYKQTPFLNWKLFPDFEHLLTQTKPDIAVPAFQKLIAAAKEQFIELEKSFEPTWEGTIGKLTELEDEISRAYGILSHLNGVKNSDDIRTTLEKIQPEFVKLGLMMNQSFPKYQALEKLRNTPEQWQKLDKVQQRIVEHALRDMKHAGIGFPPDSPEKKRFNEISERLSQLSLTFGNNVLDATKAFKEVVVDKDQLAGCSDAFLETLKKNAERHGLEGYCITLDFPIYGPFMMNCKNRELREKIYRANITKASSGTVNNEPIINEILKLKREKAKLLGYETPADLSLSVKMAQDLSSAESLLDNLFNAALPHAKKELEELTNFASTLGHPTPLQPWDTAYITEQYRKKLFKYDEETISQYFAFPKVLKGLFDVANEVLGIQVRELDPQELKQRNITRWHDDVKVFEVAEKGKTVAYFYGDFYSRPSEKRSGAWMDIVTTRFKHHDGNVTLPVAYLICNQPPPQSNQEPSLMKFRDVETLFHEFGHCLQHMMTTVDYAPASGINGIEWDFVEVASQFMENFCSEPEWIDRLAGHHKTGEPMPKDMVDALVKSKKFMTGLATLRQLHFSKVDLALHSRFTPPVSSDDPTVFDQDAEIAQQTVLIPRLEEDRFLCSFNHIFGGGYSAGYYSYKWSETYSADAYAAFEEAKAKHGQEGVRSIGQHYRNTILALGGGTSPKEVWNQFRGRTNVDITALLRHTGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3R0</accession>
    <name>A0A367K3R0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000331">
        <property type="protein sequence ID" value="RCH96854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3R0"/>
    <dbReference type="STRING" id="86630.A0A367K3R0"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="213"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="496" mass="57706" checksum="5CE88BF2AB4FB625" modified="2018-11-07" version="1">MSLFEIDYVSGAAHELRLKQQQDQIMKALKELSIKIKQESQEPQKLVMNYSDIEHDSWLTLDSSYTTLGDKNGNYSPYYDSNQGQHITKRRPSSSLRSRQWSASSCSYRSRSIPCCSVSSTHTTSYDDHDESKSIESTKVEKPKDERQVVSTPDVYGFKKPTKWINTDALREIEQRNEIVMERQLEKWQELTLNADDYWPSIGPQLFRFVKDGIPRELRPKIWMHYSGASRKKLENQGLYALLVKQAEDAGKSNEYAAVIERDLCRTFPDNIYFADDSSTKIHMLRRVLLAFSMHSPEIGYCQSFNFLAGLLILLLDSEEDAFWMMHTIVHDYFPEGMFDTKMIGANIEQTVLMMLVYEKLPGVWAKIASRKCFWECEQENNLPPITLVTNHWFMTLFINILPIETVLCVWDCFFVGSGFKVLYQAALTIIKMNEESIWEAEDSVDAFQILQNAPKRLTDGRHFIEVIFSSPSISDDITMKDINRRRRQFLQRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4E9</accession>
    <name>A0A367K4E9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000341">
        <property type="protein sequence ID" value="RCH96741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4E9"/>
    <dbReference type="STRING" id="86630.A0A367K4E9"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="290" mass="33136" checksum="FEC6857B71D6068C" modified="2018-11-07" version="1">MTKLRIICQRWNADQSKLYQPVLEALLANDITSDNVLLQKDLSNLCSITNIPRWWMRAFVRQIMLDTTVAQEIDKSSISEHTCLPTGFSSLDHALGGGLHFKNVIELCGKTNTGKTEFISNLLASYILHTTNPSVYIFGSTGSFAPKRMHDILQKHNIQTAVLSQIEFSQVFSIRELSLSLENLGALLAASTREQSLVIIEDLPSITAEINWMSSEIKHLTEIIKSLSKLQNMIIIQHNISKSNLQPKFETYWNPMIDLRLYFNKQAEYQRAYLVEILKTRYKASIYMCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5B9</accession>
    <name>A0A367K5B9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NIPA-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000283">
        <property type="protein sequence ID" value="RCH97368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5B9"/>
    <dbReference type="STRING" id="86630.A0A367K5B9"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42360" checksum="D46E26D801BD8A80" modified="2018-11-07" version="1">MDVSIQYEQQIYTKQFWIGIIVSIVTNFIQSFAMAFQRKSHLLNDSIYPIEERKHYLKRPLWVISFCAFLTANIIGSIFTIGYLPIVILAPIGALSLVFNALAAKLILGDPFNLKKVLGTCLIVLGTLLLGLFGVVSEPDHDIDDLIRLYKKPGFIAYFSCLEFVIVTSALLTHYCEYLYDQIESAALPPTTVGKWVGRWIEKDEFKKYIGISYGVLAGNISSQSMLFAKSGIELIILTIVSDKNQLQHSLTWILLIMMVGTAVLQLHYLNKGLQLCDTVIMLPISCCVFNVSCLFNGLVYYDQWDRFTWYQLVLVMVGVSLTIGGVLLISWKQQLNTLTEEEVTTIHDELLPQTDVRPNEETKLLQSNNTRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7D3</accession>
    <name>A0A367K7D3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UCHL5_2</name>
        <name evidence="11" type="ORF">CU097_003259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000226">
        <property type="protein sequence ID" value="RCH98066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7D3"/>
    <dbReference type="STRING" id="86630.A0A367K7D3"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="336" mass="38063" checksum="971DEB27036B3D46" modified="2018-11-07" version="1">MLPVDQNEPWTLLPSDPAIFNDMVREYGTKEVKVQEVYSLDFDFLNAEGPVYGLILASKCTDNDDDIIPTDTDIADINDSPVTFTAQVITNICGTLALLAVLFNADIYKGALLESFLEFTRGFSPVNRGMALGNSPQIRKIHHLYTTLQQKSDTLMMDIDDEELASSNQELVDTENYHYVSYIYKAGFVWELDGLKHGPVKLAPSTENDWLNTLKPFLEQKMTASEDNGIAFSLMAVTYESLTNKQDNEDIDDLIRQKFDYFPFLEKLFTVAYEEGLLQECAEFKKHVKAVKRQVASKKKSQKKSKATKGKNKVKLTTEKPIEKKKRGRPSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K874</accession>
    <name>A0A367K874_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ccr4 associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAF17</name>
        <name evidence="6" type="ORF">CU097_006912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000205">
        <property type="protein sequence ID" value="RCH98329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K874"/>
    <dbReference type="STRING" id="86630.A0A367K874"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="31428" checksum="3165B66432FE9EA4" modified="2018-11-07" version="1">MITNHMPKISPGGDGFFTAFLTPQGRMLYDAFIYPVNIGVNFPHPKFIVDIPTASKDMFVRHLKRYILRSKVKVRDCSDEYKLWHIWGDALNHEHRVNPTLIKKEKRLSNVGCHDPRVPGFGYRAALPADQSIHHSLHELGDFKELEIDFRKGCYIGQELTIRTYHTGIIRKRIVPVQIYRKDESTPRIQVVDRTYEYPSDALQPQKDIKLADGSSKRGVGKMCSGIHNIGLALMRLEHVQKFAQGEDVAFTVDNDVYVAPFLPEWWSENQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9B1</accession>
    <name>A0A367K9B1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CCR4_1</name>
        <name evidence="25" type="ORF">CU097_007979</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000173">
        <property type="protein sequence ID" value="RCH98757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9B1"/>
    <dbReference type="STRING" id="86630.A0A367K9B1"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="321"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RCH98757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="665" mass="74338" checksum="71CBFDD1265674B9" modified="2018-11-07" version="1">MSFDKEKENGPLNSNSYFNHSLHQMFNSGNVAAAFTTSPRTSPSVANYSMSMYGMPTTANANANTNTFGARFPLQPQAQPLLGGAPTEAATPHLARQLQYAQISRQSSSPHHHARAAAAMARNTPISTAVTITDPNDPNKFANGHGAFKTKKTTTRANEENQTWTSLDMGGMGLKNISSAICNYKFLTALYINHNNLTYLMPSLAQLTQLRVLDISGNKLSMLPPELGMLINLRELLAFDNNLVTLPTEFGNLYQLETLGLEGNPIQADIKNILIKDGTQAVIMSLRENAPVGMPPPQREWVPVEGDTGEDDSDKFSVLCYNILCRKYATSQAYGYTPSWALSWDYRKELILTELSHYNADILCLQEVEMGNYEDELIEHFAKAGYEAIFFPKTRAKTMTEKERRVVDGCATLYKTSRFKLIEHQMIEYNQKALQRSDFKSADIYNRVMNKDNIAVLSLLEDVVTQQRVLVANTHLHWDPLFADVKLVQIGVMMEEIQKLANRHLNEGSVTYGHCSKLPTVICGDLNSAPDSGVYEFLSKGSVAHDHEDFGDHSYGVYTTEGLSHPYTLKSSYGTTQELSFTNFTPEFKGILDYIFYTTNTLEVTSVLGNIDNEYLSKVIGFPNAHFPSDHIPIMAEIKYKPNNKKDQTRPADFSSTNTIKNNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9M5</accession>
    <name>A0A367K9M5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000163">
        <property type="protein sequence ID" value="RCH98885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9M5"/>
    <dbReference type="STRING" id="86630.A0A367K9M5"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="527" mass="61256" checksum="8AB98D1E4A63697A" modified="2018-11-07" version="1">MSDISEYILECDLNFYRTYALPIIKNNPEIFDLDGFQSILHENENISLHRTIQEAFHEFELDKQSQYELNPKYGRYVWDMADQWYQKWSVVFSIEHMCNWVTNSSSKPTKVFDVTAWLTHTAKKYYIHPDHLKLLQHLSHYIADWHQSNRPLALRGVFKLNTVPFFPPTWFINKSRQSKSEGLAPSYLATFVPPYRLSDHQVPERWNQVFLKGITVQPDQKFNLDPILIHSTLHILGITTDYDEESQTSKLMFVMPKAKFGNLESHIDREIPKDYLKPCQLALSITKDVKDLHWNFIHGNIHPRNILLNYADYVGELVDITFMKRNNDKSNMAWAGRWPYVAPEVVSTGLSTSADIYALGIILWQLISRVTFPDDALVDPHIYRIEPIPDVLKEWQDIYIDCLHIDPSKRPNAYTLHRRLTTLCTKLKQSPVPLSDITTDYIKARRTEIDQFLSSYRKLSPQELYVSSPMPTSTSSTDSHTSTSSSNESRSTLYQVGDQVLTASVTRPSHQRLRSYPSLIQSFPSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9W6</accession>
    <name>A0A367K9W6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_014930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000154">
        <property type="protein sequence ID" value="RCH99004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9W6"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="808"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH99004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="865" mass="96634" checksum="B0775F0E162309CC" modified="2018-11-07" version="1">MSHPTESSSLLERRRQSKSHYYTSDMSVPLPSPSPNITKEDTDGRGEHTRYHKFRLFNKRSGLYDEDRQSLVNESTGVRVWNESYSSIDWIHDRIKEGIRKRKLRHIHGAKGRLMKTGDAAQAWILVTIIGTVVAVIAWCIDVVQEWMSDLKQGYCSNNWLLNRNFCCWETKEGECHAWRSWPSVLQIEGETESYLTSMFVYTAFGLLFSFIAASMVKYTGEKVRVRKEPGHVTFSKSSSMVSVLSDNKQHNRVESPQYETRTAYYSAGSGIPEVKVILGGFVIKGFLGIKTLIVKSVGMIFSTSAGLTVGKEGPFVHLACSAGNIACRLFPKFNKNESKRREILSAAAASGVAVAFGAPIGGVLFSLEEVSYYFPMKTMIRSYCCAMVAAIVLKIMDPFGTGKIVLFQVSYDKDYHLFELVPLVICAALAGLFGTLVTHFNIRYQHLRKATFIGRHPITEVLCIMVLTSLVCYWNPFARMSLTEFAAHLFSECSPTNDNGGLCARTIAEIPQLLYLLVTTLVIKMCLTTITFGCLVPGGIFLPSLIIGAITGRMMGLIMQYVTTTHQTAWPFTACAYDFETRGECVIPGVYAIVGAAAGLAGVTRTTISLVVIMFELTYSLTYALPIMISVMVAKWVADAIFVEGIYDLLIDLKQYPYLEAKKDYVHTMTIMDIMECLPSIDADKPVSIEQLKQKLRVIAALGYSEDGGFPVLSEGDVLEGYIATSELSHGLDLLEAALKRRMTEEEIAQVSCYIRKQPSENYMITTLNQGLKTPIRNLLTVTKDHDSINEDMLVTKQALNDFSLYVDHAPLTINQNASMTLLMDMFTKLGARYVCVTYSNGKYLGIIHKRRLLAYLKEVNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9Y3</accession>
    <name>A0A367K9Y3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TIF34_2</name>
        <name evidence="7" type="synonym">TIF34</name>
        <name evidence="9" type="ORF">CU097_014100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000159">
        <property type="protein sequence ID" value="RCH98939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9Y3"/>
    <dbReference type="STRING" id="86630.A0A367K9Y3"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="328" mass="36621" checksum="CE6C8A7A6A9BDF14" modified="2018-11-07" version="1">MRPILLQGHTRALTQIKYNREGDLLFTVSKDKIANVWYSHNGERLGTYTGHQGSIWTIDVNADSTLLVTGSADNSCKLWQVQTGRCLKTWEFKTAVKRVEFSEDGSMVLCVTEERMGYSGTVTVYPINNDINGTQSDTPIVTITNNGGAKAVVAGWTYLDKYIITGHEDGTICQWDWKAKEKVKSIKAHDSVLSDMQFSIDRTYFITSAKDKSAKIIDPISLDIKKTYTADTPLNSASIIPKHQEFVIIGGGQDAMSVTTTSARQGKFESRFYHKILEEEIGRVRGHFGPINTIAVHPEGTGYSSGGEDGYVRVHHFDPDYYTFKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA86</accession>
    <name>A0A367KA86_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000148">
        <property type="protein sequence ID" value="RCH99077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA86"/>
    <dbReference type="OrthoDB" id="2206566at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="10647" checksum="99DEE6B6401C66D8" modified="2018-11-07" version="1">MLHNGKMIAYLAAEKGSSEIQDDLTASPVPVEEDDNDISFISTTSGGTYEYQSDSFDKSNSPILAYITSFDELSPITEENLFNLAYISGNLSIVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAE2</accession>
    <name>A0A367KAE2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000142">
        <property type="protein sequence ID" value="RCH99158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAE2"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="244" mass="27154" checksum="C80C40E732C77315" modified="2018-11-07" version="1">MHIPRFSWDSSVAIRVAPLSIVYMCVIIFNPLFLRHVETTAYHFSHSLSIAFSLIFSFYMLQVEPSQNLISACIIVMFGFCIGSMGQLNFSLAGVFYALAWPAVVAIYGIYVKKTVAALRNDVWLLIQYNTAMSIVTLIPLVLLSGELKEVLTNVWFLDEFGFWLQMVITSFTGFAVNVAMIYLLIHTTPLTLAVASANKSIVQAFIATIVFGNSMSLLNAAGMLTALGGTLFYIYTKYSELYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAH5</accession>
    <name>A0A367KAH5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000143">
        <property type="protein sequence ID" value="RCH99150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAH5"/>
    <dbReference type="OrthoDB" id="10459958at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="117" mass="13719" checksum="2F4AC9257AB4C5A8" modified="2018-11-07" version="1">MLQGPTNVATAVIKTRSPDATAFVCNEDRQYFFFRSEPLLRAQFEMEIDNYEVDFEKLNNLAHSESLSNDQIEEPQSIEDLIEEITIDTSNVKLRTKNYKKYRVDQIEIIKQLSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBD5</accession>
    <name>A0A367KBD5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000117">
        <property type="protein sequence ID" value="RCH99525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBD5"/>
    <dbReference type="STRING" id="86630.A0A367KBD5"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017017261" description="NodB homology domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="38"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="257" mass="28575" checksum="21FFF02C62036070" modified="2018-11-07" version="1">MRLTLLASLAAIATAVSAVPVEKRAVKAKVYTTCSVPGTIALTFDDGPYEYTWALADTLKSKGVTATFFMNGNNWVDVEHQSVKTPAGTKTYKQVIKHVYDKGHQIGSHTFSHKELAGLSASEVKSEMTKLEKIFKSVIGKTPVYMRPPSGAYDDNTLATLGQLGYKVILWDIDSNDWRYKDIASLANEQQEYKSVIEADNKKKPHGHIALQHDVHKKTIDKLVPWVISYIKSKKNYKFVTVAECLGNTKSSAYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC04</accession>
    <name>A0A367KC04_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000105">
        <property type="protein sequence ID" value="RCH99707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC04"/>
    <dbReference type="OrthoDB" id="10376236at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="19159" checksum="D304992CAA919BAE" modified="2018-11-07" version="1">MTFENWQLGLIGLISGLILVLIMLTLYFCFRRHQLSIARKAAMREMINIDEILALESVLGKEPDHTTQLPQLSDEQPVDEVQTALSPSQQQRQRKQLPPLEQEEPKREPRREFSLSPVPDHENNIQSTTPLSNISRSSIHSHRMSATVQAGIAQTWRGPTPPWTMNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCD7</accession>
    <name>A0A367KCD7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coiled-coil domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CCDC12</name>
        <name evidence="1" type="ORF">CU097_012356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000099">
        <property type="protein sequence ID" value="RCH99800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCD7"/>
    <dbReference type="STRING" id="86630.A0A367KCD7"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="16845" checksum="872F9D873D532207" modified="2018-11-07" version="1">MDQEAQKRKERLAELRKRKLESSSQGDRSVDNAEKALKFRSYVPLDDKLKEHVEIATPNDVGETIESETKHLTKETLAEHAEKEKEEVDLFNLAPKKPNWDLKRDVEKKLQRLERKTQKAIYEIIRKRLEQDKDSFAQVMTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD00</accession>
    <name>A0A367KD00_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000106">
        <property type="protein sequence ID" value="RCH99691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD00"/>
    <dbReference type="STRING" id="86630.A0A367KD00"/>
    <dbReference type="OrthoDB" id="10440056at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14396" checksum="DB07788E86914457" modified="2018-11-07" version="1">MTPVGRAAILVRGYKDKSQLIGYTTDNEGNILQVWDHYNIADVIRLSAAADKVVVTLIEQEMKEDRVFGKESIHQENLKGFFRLSFTDYYLDCLADEVHESEEWVKAFKSMIGRVPLRLPYNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEN1</accession>
    <name>A0A367KEN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000046">
        <property type="protein sequence ID" value="RCI00684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEN1"/>
    <dbReference type="STRING" id="86630.A0A367KEN1"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="478"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="681"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="918"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1133" mass="129566" checksum="CC9E43FD65528048" modified="2018-11-07" version="1">MDDTKKKLRQLNKLAWEKEKGETPKNLDSNIKKNTAFIKKCKTSLGADMKTQLLNDINKLTLEKYISEIVGSVLEGMLKCKTSVDVSACVEVISALHQRFPDTFTLLLSGQLSKSLQPPNKQYLATLSAEQREKEESARITKQRTYLRIACELWLVGVLRSVSDGKSVLAANMNGVETHRDGVAGFVNNSTSATVSQSSSKESQKKKDEGGFIYKILKDLLSNDTDHHVNLPLVASFLKNYGQTILGIVPRKQKAAAEQHSESVTVDVDPESVVTPDIHALLMSLMQDYYKTISTHLTKVHKAIKKMERHNNEILFARGELSEENKQRFEKASKTYEKLLSHTQTLADALNEEMPDLPENEAVNKPSSGMVSSSGNAFQQNGGESVGGQGVWEDDDARKFYEDLPDLRILVPDVFLEDQPAKKNEDQDKEQQQPEEEEIIENGNNDDVDPLEEAIENVEDAAGEEDNTMKPTQTAQLEGFFARLPQCANRDLIDAAVVDFCYMNNKNARKKLVKTLLKVQRQRLDLLPYYSRFIAILNNYFPDIGEMVITALTYEFKGLQRRKNQDLIESRVKNIRFLSELTKFRVTPPHTIFYAFKVALDDFTSHNIDIVCNLLECCGRFLLKSPDTSARMSSMLETVMRKKTVQHLDSRYSLMVENAYYQANPPDKPAVQIKERAPMELYIRKLIHEDLCKKSLDKVLKQLRKLHWEDVKIRQLLVRIFQKIWKIKFSNIHLMAILASGLNRYHSDFGVQIVDGIIEEIRLGLEQNIFKHNQRRIAVVKYLGELYNYRMIESPLIFDTLYTIVTFGHEYGRPARERFCPIDTPNDFFRIRLCCTLLDTCGMCFDRGSSKKKLDNFLVFFQMYVLSKSKPPMDIDFMISDTFEMLRPQLTIIPTYEQANEAVDRMLLEQLKSIQGTDKVQEDGFDESGEGSDTSSVEDEDEEANRLDEEDEEGQDELQNVPAETDEDDVVVLKKKQEQISREDEEDFEREFNKMMTDSIESRKFEKKTAMLDVPIPMNLRGSLDRRTTVRENEKPETGKMAFTLLTKKGNRQQTKIMEIPSDSVLAVSTRSKQEAEREEQKQLKQLVLNYEEREEAAARQAAVDERNRIKGATRGKKVLYVAGGGPTGKSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KET3</accession>
    <name>A0A367KET3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000046">
        <property type="protein sequence ID" value="RCI00688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KET3"/>
    <dbReference type="STRING" id="86630.A0A367KET3"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="43640" checksum="61D0D2B72F6BF08C" modified="2018-11-07" version="1">MIASLIGTKDPTIQCDILFYPQYQNDHGQVVCYPGSVFEGVVKIKLQNSMPIHHIKLVFKAAERVNYDAMGWEKLTKTNDRLFAVRTILWGLPSNVNVPVDACPILEAGEHHFPFVCQMPVINFPPTFQHHLIATTFGMIVSIERPNSKPILSKPVPLQFQPIIETMPVKNLNGFKEQTKLTQQLSAQVLIPRLAYSIHEDHLSVPLTVQFLSQDETNLTGVSQLRAYIKCYYQISYKTFSRSEVTTVADYLQSKLPSNSLSIQLRIPDKDKLTPTLTYSRHLTVEYKLVITVKVRHGPLNIKKKLFEAPIIFGTLPPGTRAPRQLEAYSQIVDNTSALHSKPTFLRPEPVNEEEFLPAYDSEEIPPAYRSNIPNTINLPTTSIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF53</accession>
    <name>A0A367KF53_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeodomain transcription factor ste12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">STE12_3</name>
        <name evidence="12" type="ORF">CU097_015834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000040">
        <property type="protein sequence ID" value="RCI00797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF53"/>
    <dbReference type="STRING" id="86630.A0A367KF53"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="597" mass="67818" checksum="23E498C6473337EC" modified="2018-11-07" version="1">MASSYKEDTTFDQHHSLVTANRLQPPTNENTEERLGQIDELKYFLGTATNDWEPQCKVRSFPLPTGESISCVFWNDLFHVTGTDIVRTLLYRFHLFGRPVTNLKKFEEGIFSDLRNLKPGMDASLEEPKSEFLEMLYKNNCIRTQKKQKVFYWFSVPHDRLFLDALERDLKREKIGLEPTSVAIAEPALSLTLDSAQDMFDQLRKSMSLSAVAAAQALDESVVASANTSPQLHHSSLLNAADMTCTSSSHDFENDWPDNWNEKSSTDQVTTPTPSRSHSPILASFPFDSFDQDQRQRIFGAFSLFEGSPTYKQRQRKRTSSLHQHHNQLELAAINAGLAVDPHMFSDDSNHERTFICPLSRCGRVFKRLEHLKRHFRTHTMERPYSCNMCGKSFSRTDNLAQHKKTHTRSRSSSLASRTKEPKEKPSSDEKPRSENNTRLRRSHLKRNASSCSKIDTYFYNAIVNSACTSPTISPQVLMPPTSDDSVFDMSGLGVVDMPSTTNTSTDDLLLSSGYYPSPSFMWNPNGSESSFDSPYPLTASSSSSVLNESIPYNSFCDDPYYSDKDHQRFSWYSSAASSPTLCPSYIYEQELYSWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFJ4</accession>
    <name>A0A367KFJ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette sub-D member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ABCD4_2</name>
        <name evidence="8" type="ORF">CU097_013975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000030">
        <property type="protein sequence ID" value="RCI00985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFJ4"/>
    <dbReference type="STRING" id="86630.A0A367KFJ4"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="113"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="551" mass="63435" checksum="2EB8836E1DD8763C" modified="2018-11-07" version="1">MRISDSLDEPLLEDPSKPITRPLSSSQYRFDRLFLKRFHRLLRILFNTNRLRAWSTTKEARKHSVFWLYITFVFIGIGYEIIVYFVGLIPSNFYTILTSRDLAGFIRYIPTCLLLVFAVAACKSLLKFMGELFAIKTRRLLTVHLQHRYIKSKMVYNLLMNQYVDNPDQRITQDVDKFAETLQQIITNLIIAPLMAIYYTYKCWMVTGFFGPLAVLVYFLIGSLLSRRLIQPIVNAVFYKELQEGNFRYLHVRLRQYVESIAFCDGEKEEHDRANQSLNTLLTYQRSIVNNSLFLNMANESFSYLGSIISYFLVAIPIFTGALDGKDAGELSSIISQSSFVIMYLIFLFSTILQQSTKLSDLAGYTARIGELLEALDQVVENLENVEIDHPHHFDNGCDHIEFDHVTLYSPSRKLIVRDLCMTIQPKHHVVFTGSNGRGKTSILRALAGLWPSSEGTVRVPKDILFLPQIPYLVEGSLRNQLGYPSSQCTDESILSNLEKVRLSHLAGMLESFDTCYGQEWYKMLSPGEQQKLVFARIFYANPRFVGKYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH92</accession>
    <name>A0A367KH92_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000007">
        <property type="protein sequence ID" value="RCI01500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH92"/>
    <dbReference type="OrthoDB" id="2252251at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="82" mass="9160" checksum="E074EFEC6F7F29A8" modified="2018-11-07" version="1">MNTTASPEHPGNPIWETFAEWKKPKPPKNIRVVKSEQETLKEQFERFNLVDEGDAGWGDASEAQDAGWGLPNQSTDSTTSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHA2</accession>
    <name>A0A367KHA2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000007">
        <property type="protein sequence ID" value="RCI01510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHA2"/>
    <dbReference type="STRING" id="86630.A0A367KHA2"/>
    <dbReference type="OrthoDB" id="2290998at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="403" mass="45193" checksum="F838BE431C6FBE69" modified="2018-11-07" version="1">MCSDRELQKRLYNKERYEQYEEQQKNLKHNRYSIQQHQQRQQQTYSVQTATSVYAQQAQVPPHYANSNNTAANPTPAPSTSSQIPMQLPQMPIGLGGGNASANLPPPPNLATPTNSNNASPQISTLSSSSMMLGINMKGNNSSNKQHTFQTQQLHMHQVIQPSLPLPNPSIAAQKNRASNRAASNASIATNVNLISLDEFVEELKRHIDFDRKLYHIDIQSLIESMGPSAGFTQLGRKICEKVLEGTKFNFSANHQTHNSLKDRRRSTKSPDTLSTLRYYCSQRIDTAKPRKAEHPKAQLKYDCAGALTIIIDLLKKSAHVTQHQISKQFEQLKQTVNEIGLLLDSQTPYANEDFLKVATEALSEAGEMVRACKAAEENSDVIYPPNKYTLHYKKRGDYGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJP0</accession>
    <name>A0A367IJP0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005569">
        <property type="protein sequence ID" value="RCH77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJP0"/>
    <dbReference type="STRING" id="86630.A0A367IJP0"/>
    <dbReference type="OrthoDB" id="415359at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16782" checksum="A3D127038CF43268" modified="2018-11-07" version="1" fragment="single">LESSYTLAIQELYVSRDHELANIKARQVHAKEIESSSANMTSLFTRHVEEMELFEATWQSDILQLQQTQRQEYREFVIELYREYQNRSEEKPDGKEMVEAAASRVKAWDHPDTGNGEYTEGVKSIQEMGFAKDQAETALMLSNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJX7</accession>
    <name>A0A367IJX7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005623">
        <property type="protein sequence ID" value="RCH77831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJX7"/>
    <dbReference type="OrthoDB" id="2216067at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9527" checksum="6D3668FD623A045F" modified="2018-11-07" version="1" fragment="single">HTNTIEGTWYGIKQNVIHRHRNKKMTPWLLLEFIWRRKNRRDLWGAIVTGLGAVSFTPGRFNPAYYTQFEYIDDEDEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILN9</accession>
    <name>A0A367ILN9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HDAC9</name>
        <name evidence="11" type="ORF">CU097_002163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01005054">
        <property type="protein sequence ID" value="RCH78578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILN9"/>
    <dbReference type="STRING" id="86630.A0A367ILN9"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH78578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15426" checksum="0CEC4BEF281F20AF" modified="2018-11-07" version="1" fragment="single">LGGYNMTPRGYALLTKMVKDLANELCDGRLALTLEGGYELQPLASSCAASVAQLLPLNTLPDQQITTFKRTLNAVKPNMGAVESFAQVAFIQKKYWNLSDAICSPSFKFNLPSDWRATDSISTRPKRDKKPIKVPVVEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN84</accession>
    <name>A0A367IN84_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004679">
        <property type="protein sequence ID" value="RCH79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN84"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="18428" checksum="53BEAE74B3E14BCF" modified="2018-11-07" version="1" fragment="single">KHYSDRRQVALHNEVRRLKKKWITNRSRPLTAVEEAQNKATYNEIQQAKIRRNAMYEHIIDTKQKISDGQTFQARKMMEKLQRAKNNSGRRILQIESEIAEKNQNEVYSADDLEIWNNEAKQHRDELRHFYYANARVRCHRAYELQKRKFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INC5</accession>
    <name>A0A367INC5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="8">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GNPDA1_1</name>
        <name evidence="10" type="ORF">CU097_000333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01004656">
        <property type="protein sequence ID" value="RCH79184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INC5"/>
    <dbReference type="STRING" id="86630.A0A367INC5"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000004">
        <property type="entry name" value="Glucosamine-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH79184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="296" mass="33093" checksum="D3892313940C4ECB" modified="2018-11-07" version="1" fragment="single">LIIREDYEEVSDFVATYIKERIKQFNPDENRPFVLGLPTGSSPIGTYKRLVDFHKTGELSFKHVVTFNMDEYVGLPRDHPESYHSFMWKNLFMHVDINPENVHILDGNAPDLDEECKKFEAEIAKVGGIELFLGGIGPDGHIAFNEPGSSLTSRTRVKTLAYETIIANARFFDGDISKVPKLALTVGVATVMDAREVLIIITGAHKAIALAKCIEEGVNHMWTVSAIQMHPKGLIVCDEDATLELHVKTVKYFKSIEHVHHSLIGPENLSLQGGVKQLKQVMPGVNNHRRPSTPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INH0</accession>
    <name>A0A367INH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004634">
        <property type="protein sequence ID" value="RCH79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INH0"/>
    <dbReference type="STRING" id="86630.A0A367INH0"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="70"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="331" mass="36857" checksum="FBC986CE7222D73F" modified="2018-11-07" version="1" fragment="single">ETSLHPSVESAIDPSPRSSIEEANVSMFPFPTSSHESPEDQPEKKITQVAATEHPLSYTKKVTPIQQQQKSALSALIAEKATAAENPFAEYAFASGKGEAKPINLCVYIPCSFKPYEPVKLIVKPDALIDDVIGYILYDYVEQKRGPELEVESYDLSEWVLLIAEDDGEIEEDLPAVDRTRRIDRVSFDQFALCRATPSQVKQNDITRAKMGKTKPDIEALRQKKQQAVLPESTTIPTSTQQEDIPTHHLMHHRTAAQEPDPSTVAVPVPSSKATLTKATMPMTPLKYFRIKLMTNEEVSATTAIPVYAEMFIGDVLELVCRKRKLDANGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INH4</accession>
    <name>A0A367INH4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004624">
        <property type="protein sequence ID" value="RCH79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INH4"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016768368" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="8901" checksum="DA0EC25ACC711DA3" modified="2018-11-07" version="1" fragment="single">MVAYSTLVFALALNALTALAAPTDSITINVKNSCKSSIQVNQLTNDAGNPKSVSVAAGSSTTMSVPSNWGGRIWAREGCSGSSDCHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISI4</accession>
    <name>A0A367ISI4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_002299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003801">
        <property type="protein sequence ID" value="RCH80655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISI4"/>
    <dbReference type="STRING" id="86630.A0A367ISI4"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH80655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="338" mass="38598" checksum="5F119A1B0F384155" modified="2018-11-07" version="1" fragment="single">MSHQTDVFIIGSGISGLYAAILLSKIGLSIQMIDNNKTQSPSGLLIFSPRSLQLLKQINLLDAITAKGMKHWRLDIYEHNVLVDSIQLWDNDVTGYNYCLSCEQSIVCDILRHHVSLDVIKECITKIEDQDGFKRIELSHGQCWKSQFVLVENDGANLVRQTLGIGYKYHNNKRYFYTLQISILQSNFPSIRQISVIKKNQESVVIVGHQDTLYITFEHKPSWSKVSIDDEIPVALALGHIKYMMDPFQVEFGRVKSYTKWKGDQRSSELFEHEGYFFIGHSSQTTSPLLDINAYFEGVQNLCWKLGLVFRQCASTALLDTVNQETQLKSAEYIQTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITS3</accession>
    <name>A0A367ITS3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003581">
        <property type="protein sequence ID" value="RCH81104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITS3"/>
    <dbReference type="OrthoDB" id="10370112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="98" mass="10739" checksum="ACE894EAE3FC3D3F" modified="2018-11-07" version="1" fragment="single">MSIFNYVNNNGGNNRNNSNNDNLMLPRYGSFSGSYSDTATNEALAAELQNTVAQLSATQHRVEQLEARVNVMTAQQQGTSRIGRDSAMSDGYLMLCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITZ4</accession>
    <name>A0A367ITZ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Plasma membrane ATPase</fullName>
            <ecNumber evidence="13">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PMA1_1</name>
        <name evidence="15" type="ORF">CU097_000250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="PJQL01003563">
        <property type="protein sequence ID" value="RCH81148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITZ4"/>
    <dbReference type="STRING" id="86630.A0A367ITZ4"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH81148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="697" mass="75420" checksum="653AEDBFBDB78755" modified="2018-11-07" version="1" fragment="single">TVNISGDLTTLTVEELYDKEKFDLSTMEPGDVFQLLQTSSNGLTSDEAARRIEKFGRNRIESKEVNPILQFLGFMWNPLSWVMEAAAIVSIALSNGDGRPPDYPDFIGIVLLLLANATIGFMEERQAGNAVKALMAALAPECKVKRDGEWKTMEAAELVPGDIISIKLGDVVPADGRLIAAHGQVSIDQAALTGESLPVGKEAGDEVFSGSTVKQGEAEAIVIGTGTNTFFGRAAKLVGDANDDVGHLQTILAKIGNFCLVTITLFIVLEILVMYPKFHYRYRTGIDNILVLLIGGIPIAMPTVLSVTLAIGAKQLAEHKAIVTRITAIEEMAAVTILCSDKTGTLTLNKLIVDKPTIKAYAEFNGDDIILLSAYASRTENQDAIDFCIVNSLPDPKLAREGIEELEFKPFNPVVKRTEITYKRLSDGKVLRVTKGMSHTILDLCTRDKTEEQIKALNDDVDEFARRGLRALAVAVDEVPSGEVEGEGLGFRLIGLLPIYDPPRSDTKETIDRAIALGVSVKMITGDQLAIGKETGRRLGMGDNMFLSKTLKEGPPPGSGYSSVDEMVLHCDGFAGVYPEHKYEIVERLQAMGHMTAMTGDGVNDAPALSKANVGIAVADATDAARSAADIVLTEPGLSVIIEAIIGSRQIFQRMRNYSIYTCSVTIRVVVGFAILCFAFQFNFPPFMVLILAILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW76</accession>
    <name>A0A367IW76_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003233">
        <property type="protein sequence ID" value="RCH81902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW76"/>
    <dbReference type="STRING" id="86630.A0A367IW76"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15359" checksum="942CFF0E59C95301" modified="2018-11-07" version="1" fragment="single">QLSEQYGILDKMERIMDTDNDEILIVTISSIGLIGSHLAGLDLLLSNNPTMISKLFNHYHSSIGPVKAVILQTLSKLIGVRDEPMNESDKLTLMVFKQYHGFPTRLIAEAKQPDDDIRTACFALMQSIAFHQWGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXJ2</accession>
    <name>A0A367IXJ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase III transcription initiation factor complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TFC3_1</name>
        <name evidence="2" type="ORF">CU097_000197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003107">
        <property type="protein sequence ID" value="RCH82201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXJ2"/>
    <dbReference type="STRING" id="86630.A0A367IXJ2"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="1">
        <location>
            <begin position="374"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="939" mass="108609" checksum="899E435D5915D51C" modified="2018-11-07" version="1" fragment="single">NRQILKKVPVPELPPVSSSLTFMGENSTAGKDNMAAPSDTLYEGSISRNAPVDYGWVQSKILRAKEMHRDILKQYFAMHSPLEHEERFLEMNQLVPSLTIGTLVKLCARLPFENQDFLSYISIHENRSTQIRSLPYAIRTLILKTPHKIRKSILRTLDVLIALELIEVCKSPFGRTMYKLSKYGKVKDYCSPNHPTLTTLPMNNMNDVDTYWKELRFYCVESRHGEGIHRKECIERNSPIANITSRRSWATNILLSKKQKEVLDTHIDFQNLIVPVEDANLRAYLSKKLDIPATRIRTYFMAIAKPSPAIHELMKASAEKRKVDTADPQMRQSPPFVQRTFIGSRKFRKLRVRVQPKEDMSEGGYSMNYDPLPEVEKDVLLYSYCIMRSRAKRSLFYWSPITKVLPHREPEKCRRTICTMALMDHTLVHTIQRLTTQWEHIYKQGIEKGDICDDSPWDSIHFDLRGYLEYFLLKLQEGYESTNDTAFDAGIEMYALPKNCDALYRQFYILKEEFKDKSNIDRVPSQSLQIPEARVGPQYRAYLDKHQQYEHEVLVELVKTLIKTLLVIPLESYTPKDAYLLMKQYPESVIEEAFNQLKRNGLIVYDRSAYGRIPGRLINVSEKFMTLASSVLPHDLFQEARSHYLNLANRNNIMLTKDINSGQVAATLDLLSQNKICLDMANRANYIQSKQSVIYPKLSAVPLCELYVYKGLDITVSRTEDLQLPTPTLNWKLTRVIPVDHINHYLTMIKTTNPLSHHIYMALKEYGALGASFDCASTKIRDSNPHIQIVDIVTAFDTLIKHDPPLIYLVGFNRLRYTAAEHVHHWLLKGTKKDTYLDPLIWCDISGSVVRPVLDGCCEVVMSHIIKRPGIQYSQLRDALIGFLSEYELYTILKYLVDKNKVISRKACQSTNKRSIFGKKKLRLSKNELYTGEQIHYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXN7</accession>
    <name>A0A367IXN7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UFD1_1</name>
        <name evidence="7" type="ORF">CU097_004451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003011">
        <property type="protein sequence ID" value="RCH82448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXN7"/>
    <dbReference type="STRING" id="86630.A0A367IXN7"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH82448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="313" mass="34818" checksum="FC970DC470FFA395" modified="2018-11-07" version="1">MFNDEDSFSNSFFGGFRPSFGGFMNPNRGFSENYRCFPIAMMQHGHDRENVNYGGKIILPQSALEKLSQLNISYPMLFRLFNGAERTHTHAGVLEFIAEEGRVYLPQWMMETLGTEPGSIIEVKNVTLPLGSFVKIQPQSADFLDITDHRAVLEKALRNFSTLTVDDIIQINYNNKVYEIKVLEVKPSNEEHLGISIVETDLEVDFAPPVGYVEPSQPVQTVKSQMVIDLPKPVKTGFTAFQGGGQSLRGKSKPNTTDESDAENGQDDGPLDLPFGTLYFGFPIIPPPSSNANDQNEKPTFTGTGQTLRSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXY1</accession>
    <name>A0A367IXY1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002978">
        <property type="protein sequence ID" value="RCH82550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXY1"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="28034" checksum="8596AF4A34FAA2C8" modified="2018-11-07" version="1" fragment="single">MEHEHHIKITVPESAQDLRVRKFIVQNYRHVFKSKENIHRAFNRKEISINGCPTEETRRLNTGDIIEINYDKSIEEAERLETIPIDILYQDEHLAVVWKPPGQNSAVFEKAIHHNTAEIDSKGNKQKIWCINDIQKAASGLILVAKSERVKELLMESYMNDKINFTMRVICHGRIDTTVMSDLFCLDQSDKTQESKVNPKDVLKSINIISATRSNHAQYITTLDLHLHSPLSSLQLRKLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZZ2</accession>
    <name>A0A367IZZ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002761">
        <property type="protein sequence ID" value="RCH83139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZZ2"/>
    <dbReference type="STRING" id="86630.A0A367IZZ2"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="239" mass="27671" checksum="9BFCA7BE71233EAD" modified="2018-11-07" version="1" fragment="single">MLNNFLSQFRFSNPLSMAIDIPYQRVHNGQNELKGSLLFKYRLAKALTMGSLIAIVLMAAYSLFYPNVVYDKDNTNISEQDNTLPVTFTPQEGRCHLPREILIERPTDGSYAPPSPHNSLLRAVSYASNEEYQNYCKKYDESKGGYTDEWKYNENGECGNWQEEYIKLHQRNMAMMEKYKKGEFPKNIDFENRPKFISYLCKEVPVNSNRGCGGLADRMGGKEQHRLLTPYTMAHYMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0A7</accession>
    <name>A0A367J0A7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_008247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002687">
        <property type="protein sequence ID" value="RCH83367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0A7"/>
    <dbReference type="OrthoDB" id="2257429at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="64" mass="7366" checksum="60C67F67DBBF4EF4" modified="2018-11-07" version="1" fragment="single">MSARENEQRAKEAVDKTAHNAKEELERLRAEYEDLKRRTQPKVQEAQSYLTSPSAIGFYQGVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0L6</accession>
    <name>A0A367J0L6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A1-alpha2 repression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AAR2_1</name>
        <name evidence="4" type="ORF">CU097_005818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002647">
        <property type="protein sequence ID" value="RCH83482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0L6"/>
    <dbReference type="STRING" id="86630.A0A367J0L6"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.20:FF:000001">
        <property type="entry name" value="protein AAR2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="2">
        <location>
            <begin position="186"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="357" mass="41768" checksum="95EB9EF8EC2A2909" modified="2018-11-07" version="1">MDQELANKLFEIGAFILFLDAPPNLEFGIDYNAWTIGPLFKGVKMIPPGLHFIYFSSTSKEGVQGIRTGFFHFFESKEILVRVWNPQTEDLRDETEIDPAQAERYRINIREFDRNMGPYPLNPPLYYERWKKLTNFITPGLVRRVLPNNGKVSHLPEKNANLTIDESNVKDKRLGRQIEKEEGMEFTPFDLRKSFPTGASGDEITRWSLDKSWLVKDLLKRVYHNDYRIMLGELQLAFVCLLMAQNFSGFNQWKQLVQLLCSCQQLMEDNPNLFIDFMDVLQFQLDECPEDFFRDILSENNFTSVMLKSFQQNVPSSQPKLIDRYSKLKKFIIKKFDWNVPDDEDDDDDAPVVVNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0T6</accession>
    <name>A0A367J0T6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002623">
        <property type="protein sequence ID" value="RCH83558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0T6"/>
    <dbReference type="STRING" id="86630.A0A367J0T6"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="74797" checksum="C230BEDBE3D89927" modified="2018-11-07" version="1" fragment="single">ALESSPDLHIQIKADPVHKTLTIRDTGIGMTKAQLKENLGTIAKSGTSEFLAKMQDNKDALNQIGQFGVGFYSVFLVADKVTVASKSNDEEEQYVWMSEAVNDFTIAKDPRGNTLGRGTEITLYLKKDAERFLNEKTLKELVRKYSQFITFPIQVWSAHEVEEQQDDKDELDEGETKTESKKKTVYDWDRVNTQKPIWTRDAKEVTDKEYNEFYQSLTLDRDEPLGWSHSKGEGELEFRSLLYIPRYMSEKFYQTMQDIKPIKLFVKRVFISDEFDLLPRWLSFLRGVVDADDMPLNVSRETLQKHRNLRIITRHLVKKALDMFSQLSQSNPDKYNAFLTQYSAMLKFGAIEDTAYRKKLTSLLRFASSHNTTAYSTSLDDYISRAKANQKSIYFMTGSSVSEIEQSPFIESLLARGYEILYFTDPIDETFVEHIPGYNGKMFANIAKGDLELEDSMDTKEQEEKYKPLADWLKDILFDHIDKVTISQRLTTSPFAIVAPKHGLSGHAQRVLDAQGHNVKNPQMEMVLESLKLQKKILEINPNHPVIEKLLKYVEEDNMPEDMTNLVQLMYETTSIRSGFPLRDINQFTSRVEGLLRKNIGVAMSEEAKVEVKKAKEKTEQERLEDEEMKKTNVVYDDFNEPIEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1E0</accession>
    <name>A0A367J1E0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002595">
        <property type="protein sequence ID" value="RCH83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1E0"/>
    <dbReference type="OrthoDB" id="10427620at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017041144" evidence="2">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="11438" checksum="FE096AE61514A84B" modified="2018-11-07" version="1">MKFLSSAILLALSIASTQVFADTVNAEDAANANSEQNQNVEAGYVYPAAFHPYMLDYYPNWNHLARRGRNFGGCGWSGCGGGGGWGGPRLPPTPPTPPTPPTPPFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1E7</accession>
    <name>A0A367J1E7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002564">
        <property type="protein sequence ID" value="RCH83755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1E7"/>
    <dbReference type="STRING" id="86630.A0A367J1E7"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="249" mass="29287" checksum="2F98FB8F3CE171FF" modified="2018-11-07" version="1">MLAIANTNTPTVNNSTRLVSFFLKKKKSSWSLRSFSKNKKIFTHISTSASSLPIYTTQDEDYTLPPSYDDKSHPWAFQFPKFMTSRVIHPREEEGREELPDYECTVEKMGSAYVKCEMTEPGVRSTNRSWRFLYLQVRGTMILGYKHNPKHERRTQPIWIHSMQGAQITVATDYMKHRHVLRLQIANGPQLLIKTQTDADKMNWIDAIESSINISTDIDYRDMPQFITLRVRHRRHHNRDRRPMEETLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1W8</accession>
    <name>A0A367J1W8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-like 6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ACTL6A_1</name>
        <name evidence="2" type="ORF">CU097_001468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002510">
        <property type="protein sequence ID" value="RCH83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1W8"/>
    <dbReference type="STRING" id="86630.A0A367J1W8"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="295" mass="33644" checksum="50625CD8AD22288B" modified="2018-11-07" version="1" fragment="single">MVTYGGDEVNAVVLDMGSTSTRVGFAGEEVPKTIIPTCYGVDQNNNYHVGDAQLNTWRPNVEIKNPMEDGMIRDWDAVEQIWKTAFQDYLHINPSEHPFLCTEPAWNTTENREKLMELAFEKFDMPAFYVAKSPVMTAYSVGRATALVLDSGGSITSAVPVYDGYVLKKGILHQSIGGDLLSEQIKEHLKNDLRMNITPLYKIARKKPVGAGERPQVELRERPNTTKSFEDYHISKIIHEYKESVSQVSEIPFDERLMAQRPQRPFEFPDGYNTTFGVERYRVPEIMFNPHHIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1Y6</accession>
    <name>A0A367J1Y6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01002508">
        <property type="protein sequence ID" value="RCH83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1Y6"/>
    <dbReference type="STRING" id="86630.A0A367J1Y6"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="187"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="32116" checksum="CE0DC3893D37DC0A" modified="2018-11-07" version="1">MTLLSRIQTISSHLQGKISTKPIISFIGGGNMAEAILAGLQSTGYPSTNLRYSEPSEERRVYMQSKYPDFSSTADNLIAAEGANIVILSVKPQVLKSVVTSMASLFNKDPSILLVSIAAGITTSDINKWINSKHPVSIVRCMPNTPALIGEGAVGLYATHAVNNEQRELAESIMKSIAKQISWITDESHMDTVTALSGSGPAYFFLMMEAMENAAVEAGLSRDVAKALVMQTCLGAARMAQESQDDLATLRKKVTSPKGTTEAAIQSLESNQFKKIISDAVFAARDRGKELAEQLGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J296</accession>
    <name>A0A367J296_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_006548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002472">
        <property type="protein sequence ID" value="RCH84064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J296"/>
    <dbReference type="STRING" id="86630.A0A367J296"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="165"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH84064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="430" mass="49155" checksum="F8869ABBAEB30C1F" modified="2018-11-07" version="1">MLILISNDEDRRLMLQGRANRAAQLAVANTAAAVALSAKLSIIQRYFYGVEKTLSWHPWFGRIALVETLYHGAYQFQLNYIRQNYDLIHTLTTNIRYITGASLISAMIVLVIGSHPLVRHISYRLFRLTHIGSFLVLILLGCLHHWVFYVFYAAVLGFWIIDQVDRSFEIEVCSLQAMPGNIVKIQATVPYTILSPIPGQFAFLSFSSSWIHAWIHSHPFSICRIDTVDGKDQDDESEGMVHQALTFYIKVSGKRTLSLYQKAVDQEKVKMRISRPLGRPYLTIAGSEFGDFKTIVLIADGVGLAPWISVLQYVSERKETIKTRSVYLIWSIHAIDTFYAFEEELVQFANSLQLLDLTIEIFITGNIEDSAESVRQFTFRYSRPNYSLLFDEIYENDVAVGVCAHEDKTVQIHNLALARSWAIHTERFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2E4</accession>
    <name>A0A367J2E4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002525">
        <property type="protein sequence ID" value="RCH83891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2E4"/>
    <dbReference type="STRING" id="86630.A0A367J2E4"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21931" checksum="7AFA32962A833B79" modified="2018-11-07" version="1">MSAPPTPNTHIPSLDNNISFTTVPPIEEDVKENNNVDRSMLRAGLDKQSRIILMSTIGSLWGFGIGAFIGGRQSGLQYLAENAHKLPTTVQGWYFYHKTKNYKMMLGGVKKGIRYAGRTGGLCLLYGTLEAGLDEVKGQADVVNSVTAGVATGTIFSILSKLPKGSFRYSVLFGATFGLVAGGLTELHRYVSYVSEDEAYVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2V6</accession>
    <name>A0A367J2V6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002412">
        <property type="protein sequence ID" value="RCH84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2V6"/>
    <dbReference type="STRING" id="86630.A0A367J2V6"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="104" mass="11378" checksum="762B73243ED704B3" modified="2018-11-07" version="1" fragment="single">PEEPKVNDDWDSIFGVSSTPANNTAPVTQHVTGFDDSFSNFADDFGKQKAPKSPPTAQTTTPVGDKVQDLIKMGFGEKEAKDALNRYDQDLEKASNFLLDQVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J497</accession>
    <name>A0A367J497_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002272">
        <property type="protein sequence ID" value="RCH84772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J497"/>
    <dbReference type="STRING" id="86630.A0A367J497"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="188"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="300" mass="33349" checksum="64CE5648E12C0B82" modified="2018-11-07" version="1">MFKQVLAMTSRQYTMLQKRSFASLISVQELKSNLENVKILDGSWHMPNSNRDPYDEFLKKRIAKSQFFHIDGIKDTSTDLPHMLPSPEVFANAVGKLGIDQHDHVVVYDTVGVFSACRVYWTFKAFGHDTVSVLNGGLPAWDGPTESGVPEKVREKHYKVPTINAQIVRDYPTILANARKAQSNEDYIQVLDARPYARFTGQAPEPREGLSSGHMPGSISVPFGEVVGPDGKLYDDEKLKQIFQAKGVDLSKEIITSCGSGITASILFMALERAGAKNLAVYDGSWTEYASRNDAIIIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5Z4</accession>
    <name>A0A367J5Z4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002129">
        <property type="protein sequence ID" value="RCH85315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5Z4"/>
    <dbReference type="OrthoDB" id="2284137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="152" mass="17158" checksum="1043BCBC7B2D86E6" modified="2018-11-07" version="1" fragment="single">MLLQDTEPLLPSTLLMTRNGSYWNIIPGSSQRIVRALDYVGDIINEEVGQLRKDKDHKSPVSGTAANEKENILPLQAEISEGASEKQASASSAFNENEDYIDSFVENEEAETESQTTIHHVLKLHKMEMSINYLTFIKLKQPNYQFNTGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J660</accession>
    <name>A0A367J660_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002097">
        <property type="protein sequence ID" value="RCH85442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J660"/>
    <dbReference type="OrthoDB" id="10292687at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="320" mass="36539" checksum="CCE1C7512F179484" modified="2018-11-07" version="1">MATPLREEDLNERRVNLWQQFTRVAQPVCSTNLFDDHINSSTDYGTASEHTYRGEDEDLLVFDDVEDNIEVWDNNRLQQDSSDEAEGVLYFSVDALMRESNDDTIEPSCSKQIELGDGFILEFMDSSDDEEGKKCGHDQQHVVMPNYGCSSGTCEYSITIEFDEENEFNSQPSWLLEDILNNPFMIKYTKEEMLKMQANVESYYHKDGLAAGSLIYGLIAKGKEEAKAVRPKRNSNYQPRRRGHEDTESYGENGEGNITKAIVPCVPIRQPKNPDNDEQQAGFYCDADGKDKNTEQKNVLYINCSICKHVVCLDCKQYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6J8</accession>
    <name>A0A367J6J8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microfibrillar-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MFAP1</name>
        <name evidence="4" type="ORF">CU097_003980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002069">
        <property type="protein sequence ID" value="RCH85553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6J8"/>
    <dbReference type="STRING" id="86630.A0A367J6J8"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="165"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH85553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="48067" checksum="AD276210517C5786" modified="2018-11-07" version="1">MSFRSPAKNTPKPKAPVKRYRAGQVPENYVDELSDSEEEYEEQQQKQQKQPQTTKAELTFAQKEVRTGIKQTTISEQEASTDRRLRRLQQLQLDDQDRSARRRHVQDDDEDEQEKARERMRLKQRALEQQDALVQNVEEDEEEEEQKSEEEEEEEEEESSEYESSSEEEDTLARLPKPVFIPKAKRETILQQEQLAKEREERERRLEEELEERKRQSHNMLAEELKREREEALNKDLSEYDDIPDDTDKVDEEAEYEAWKLRELARIKRDREARIAREREEEEIQRRRELPEEVRLKEDLQKAEETRKKEKGQYTFLQKYYHKGAFYQNTEDEIFKRDYTAPTVDEIRNKELLPEVMQVKNFGLAGRTKYTHLVDQDTSTKDSPWSKPLAKRRRRNEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8E6</accession>
    <name>A0A367J8E6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single stranded nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SBP1</name>
        <name evidence="3" type="ORF">CU097_008791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001924">
        <property type="protein sequence ID" value="RCH86175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8E6"/>
    <dbReference type="STRING" id="86630.A0A367J8E6"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="171" mass="19892" checksum="EEF8408AC0A2BD65" modified="2018-11-07" version="1">MSDTEEKKPVEQQEVEEEPDVHFEPVIKLDQVETKTNEEDEEVLFKMRAKLFRFDAGAGEWKERGTGDVRFLKHKENKKIRLVMRRDKTLKVCANHYVETYMKLQPNVGSDRSWVWKVSADVSEGTPTAETLAIRFANSDNANAFKEEFEKAQTHNASLKAEEKKDEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8U9</accession>
    <name>A0A367J8U9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalamin adenosyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001889">
        <property type="protein sequence ID" value="RCH86340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8U9"/>
    <dbReference type="STRING" id="86630.A0A367J8U9"/>
    <dbReference type="OrthoDB" id="549173at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH86340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="15448" checksum="CF48EFA52945B742" modified="2018-11-07" version="1">MKIYTKTGDQGTSSLYNGERRQKDDEIFEALGTTDELTSNIGMAIEFLEDDAHWGPYLVDKLTTIQCLLQDIGSNIATPRQQSSESRLNRTAFDMTHVSKLEEWIDEMDTELPRLTQFILPTCRKTCTAFVSSSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAD2</accession>
    <name>A0A367JAD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MIP1_1</name>
        <name evidence="7" type="ORF">CU097_003148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001771">
        <property type="protein sequence ID" value="RCH86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAD2"/>
    <dbReference type="STRING" id="86630.A0A367JAD2"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="6">
        <location>
            <begin position="624"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116085" checksum="1F1142A79FDC8704" modified="2018-11-07" version="1">MISRSTLQQTVKCTRYRTCNGTRFLSTNNVKINPAHVQLLSPSLHAQLFEPYESQESKINNQEYSLKKKYAEEHLKLQGIWGKTPQKEDPIDVKLPKLMGKNLEEHFIRIGLEQAEPYLSQCEKLVSIDIPPTPTQWKKAAGWTRYGKDGTITAVDYPLEDTMVFDVEVLMSEGNYPTIAVVASEEAWYSWTSPYLLDQTKSKEQLIPFGRRDNKRVIVGHNVGYDRARIAEEYSRVDSNIRYVDTMSLHIAVSGLCSQQRPAWNAELRRRDQEPASNEQTFFDVSSLNSLKDVAKFHCKINIDKSQRSIFETGSLSDVHTQFNELMDYCAKDVALTHAVYKAVFPIFRKNCPHPVSFAGMLHMGSSFLTVTERWEDYLQKSSGKHKELSDMLDVKIRDLAEKARVLVDDPVVWQNDPWLSQLDWSVNPRQRKLKGSPKWYKDAYDTKTATLKISTRSRIAPILLRLKWNGYPLHYIPSNGWCYKIPNSEVAVEQSSKAAARDDTYHYFKVPHKDGEDANCGNPLAKSYISSFEDKILTSEYEAAREALELNATSAYWISSRERILGQFVVWDSNSSVHMHLPRKSEGKYGMILPQMVTMGTITRRAVEKTWLTASNAKKNRIGSELKSMVQAPEGYKIVGADVDSEELWISSVIGDAQFGFHGATALGWMTLQGSKSEGTDLHSKTANILGISRDKAKIFNYARIYGAGVKYATSLLSQYSQGIDQKTAEQRALELYSETKGEKEHSSKNIFKRTFWHGGSESYMFNALEDIALSREPRTPVLHCAITDALKPQYAKAQFLTSRVNWVVQSSGVDYLHLLIVSMNHLIRRYNINARFMLSVHDEVRYLSSVEDKQRTAFALQVANIWTRAFFSYKLGIHNLPQSVAFFSAVDIDHVLRKEPNMPCLTPSNEEKISEGVSCSLLDTIRELEADIGSANNLECLLGNSESSEQMKVDEKTIKSLIDKTKKRKTKVDLNFIKAQMYKDYKNHFEQTLKGNRETEEVIKCGDNLEAIYMDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDB3</accession>
    <name>A0A367JDB3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LAP1_1</name>
        <name evidence="11" type="ORF">CU097_007083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01001557">
        <property type="protein sequence ID" value="RCH87962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDB3"/>
    <dbReference type="STRING" id="86630.A0A367JDB3"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016487822" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="164"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="378" mass="42567" checksum="5467BD2FFF56B56C" modified="2018-11-07" version="1">MKLISLSFLSLSALAALVNASPLIDQIRIFDVPEPQRRLIQYSDDVPPKWMTESDKSALLRAGIKFMDITDHPNTPITSFAVETPAIPTKAIYQQEAEPFIGNLTTDTMETVLTHFTSFRNRYYKSKYGAESCRWLIQQIRDIASGNDHVSVKEFEHSWDQFSIIARFEGSIKDLENEVVIIGAHQDSVNMWLPSFGRSPGADDDGSGTVTILEAFRSLVHNGFKPERPVEFHWYSGEEAGLLGSQDVADKYYQEGKRVVAMLQNDMTGFIGKNKDKEVIGIVTDHVDEKLTDFLKALVDTYAAIPYSLTECGYACSDHASWRKLGFPSAFTIESEFDNSNPYIHTTRDVIENLSFDHMKEFAKVAVGFAVELSHVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDU2</accession>
    <name>A0A367JDU2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_005734</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="PJQL01001531">
        <property type="protein sequence ID" value="RCH88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDU2"/>
    <dbReference type="STRING" id="86630.A0A367JDU2"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010093">
        <property type="entry name" value="PRK13579.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="313"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="396" mass="43050" checksum="B0696590B1F5A11C" modified="2018-11-07" version="1">MFATKIPVSSLRPVTKRFYAAAATTGAIKKTALYDLHIKHGGKMVPFAGYSMPVQYANMGLIASHLHTREKASIFDVSHMLQSRVTGKDRKKFFETLVVADLHNMPVGQGTLSVFTNEQGGIIDDTIIMQQEDNLYVVSNAACADKDIAHIRKHLTEFQNKGGDVDFNIITDHSLIAIQGPKAAAALEELVGKDLNDFSFMHGRHMDIAGVPCHVARSGYTGEDGFELSIPTEEIVTITEKLLAHPDVELAGLGARDSLRLEAGLCLYGNDLDETTTPVEAGLTWTIPKSRRETGGFLGAEHILPQIKGGVTRRRIGLIVEGAPARGGAEILNKEGEVIGTVTSGCPSPSLKKNIAMGYVKNGYHKKGTELNVKVRNKVYSANVTKMPFVEAKYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDW7</accession>
    <name>A0A367JDW7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (cytosine(38)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.204</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA (cytosine-5)-methyltransferase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRDMT1_2</name>
        <name evidence="8" type="ORF">CU097_006103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.204" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001522">
        <property type="protein sequence ID" value="RCH88143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDW7"/>
    <dbReference type="STRING" id="86630.A0A367JDW7"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="536" mass="60064" checksum="947A3C0D0857B8D6" modified="2018-11-07" version="1">MAPLRQLEFYSGIGGMHYAANLAGWDVDILKAFDINTVANEIYRHNFNPKIVGQKLIETLSTKQYEDFAADVWTMSPPCQPYTRQGLQQGSEDARAKSFLYLMSVLKEMRNKPKYILVENESDSREMLVDALQHSDYNFQEFLLTPLQLGIPNSRMRYYLLAKHKPYEFAVPVTGTIINYIPLSEKMSKAFIDNRGQEYVDEAEVEAISAYLEPNVDEQTFLVPDKVLLKNMQVFDIVKPTSRRSCCFTKGYFHYAQGTGSILQMSESLDTAIVFQQAMEYKDIDESKQLELLKSLRLRYFTPREVANLMGFPDQFSFPNTSSLKQKYRTLGNSINVKLVSELMRYLLKEPFASSNQNEKKHASDSIKKSFKTFCESISLTQSRSKRRAHSVLKRESRGTPYKRLTVLPGFNVLSIMAVHFLTPRLVDDEILEDGVVSWLLSNCFIWAFGDSVIDGATAVGVAFFGFDSNIKGVSLLLGSENFTVGEVLLFNVDVATVGGAFDDEVATVGGTLDVAVTVGGVLGVVTVSGILNGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEE9</accession>
    <name>A0A367JEE9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001491">
        <property type="protein sequence ID" value="RCH88306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEE9"/>
    <dbReference type="OrthoDB" id="2233065at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="365" mass="42100" checksum="47595B2EA33A7634" modified="2018-11-07" version="1">MTQSSDEQDVLDDISTFALSRHHLPGTDRFSKLILQTPSLIDLIALELLDVPGGTYTAAGTEWSDGTRSDVLYVPRLGVQQRSLPPILIEVQLVVNEAFMRRLQNYGHKIFDLYKSYPLVLVFCTDRVSPTSLMDDFQCPDRHPWMYMLKSCRFWAQDCYLLTKTTLANNGNNNNWSPLYALSTFIIEQSPTLYGHSNPEHPTIRMLYRLAKECINEKMESERHLSHVLDVVCTNNEKLLQKLEKSIADIPGTSKARRILSSAFEFNRSVKRKYVELEDSDSSLEPLPPNRTPSRVSSQMSFNMERSRQEDDLMFIINFRKNQTGKMNWNLCLKEAHKNHLCKGFSTVEGIRSFFRRSMKTQVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF63</accession>
    <name>A0A367JF63_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001453">
        <property type="protein sequence ID" value="RCH88515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF63"/>
    <dbReference type="OrthoDB" id="2283183at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="23140" checksum="ED82EAB438285432" modified="2018-11-07" version="1">MSESTIHREASNDPFNGRLLVARRVVPGSDLISKAILTDDRIINIICKSLNNSPQDHYMAAPSEFLNKSACDVLYLPKVALSEYPPIIVEVQKNVNEKYSKYPIILIIGVSTAKRCLLMSSITLSKNGSTEQLDPLAAISMFLCSQKLSITHLDCGSDDSTMKLLYKVAMTYVQQLVGEETEKAEVIQLICDNTENQIEKIKRCIQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF87</accession>
    <name>A0A367JF87_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_001693</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="PJQL01001442">
        <property type="protein sequence ID" value="RCH88577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF87"/>
    <dbReference type="STRING" id="86630.A0A367JF87"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="13">
        <location>
            <begin position="365"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH88577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="50343" checksum="2A21E5E0A8254D17" modified="2018-11-07" version="1">MEGNKRQEPMTMPESKRQKTLTSLSDEEMAPATPSDVDMQDANENNVEKGIIDTLDASKIKIALEECKILVIGAGGLGCEILKNLALTGFKQIHVIDMDTIDLSNLNRQFLFRKKDIGKSKAMVAAEFVMSRVPGVQVTPYFGKIQDKDDEYYKQFQLIICGLDSVEARRWINAKIIEMVDEDDMEHTWKPLIDGGTEGFKGQARIILPTITSCYECSLDMLSKPTTFPICTIANTPRLPEHCIEWASVLEWPRVWGSKKYDTDNPEDINWLYQQALTRAKQFNITGVTYSLTQGVVKNIIPAIASTNAIIAASCCNEAYKLATCVAPHLNNYMMYTGDAGVYTYTFEHQKKPECPVCGNESKTAELDKDTTVSQLIEYLAERSDTQLKKPSLRTATKSIYMQAPKALNQATLPNLDKLLSEFVSEGEYITVTDAALPVSLQLKITWKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFD3</accession>
    <name>A0A367JFD3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001428">
        <property type="protein sequence ID" value="RCH88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFD3"/>
    <dbReference type="STRING" id="86630.A0A367JFD3"/>
    <dbReference type="OrthoDB" id="2206543at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="320" mass="36615" checksum="4238D1EF5108172A" modified="2018-11-07" version="1">MANLLQFVSTTTETPSDANAQNSLEISGSSSPSPENNGLTSSVTIADLQSTIEKLYAELKQTQAELKQAQEEIQALRIQQTFADSWPYTDLNDSQFPPLHPPSQPLPPWRGTARLNSIKTFMLEKRQQRRIQRQETAARFLQPPFENQGYQYIYTPTKARVPVGQLRNRLRQLDINNSRILNIHYLTHNVVALLVHSDYAFELKSHLQKFKVRTKGDFNPCDGSILMDHKYEHCSKEEPDDFAFMYHSDCVKKALTYIRAPVKTAVARYFDNQGWISKSVLDESLPTKVINPTDVFNVDEDAAMLLSDREEPPLNYNDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFK7</accession>
    <name>A0A367JFK7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001429">
        <property type="protein sequence ID" value="RCH88649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFK7"/>
    <dbReference type="STRING" id="86630.A0A367JFK7"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000073">
        <property type="entry name" value="esterase OVCA2 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="25783" checksum="58FDFAF65B865B92" modified="2018-11-07" version="1">MASHKLKILCLHGYTQNAIMFQKRTSAIRKSVDHLAELVYITAPHHIKPPTLSSEYVAESDDDVSEEHKPFGWWYAPRYKPTKDGYFIGYKESVAYIQQVLKNQGPFDGILGFSQGAAFAALLTELLENKSHEFSSFDHPPFKFTILVSGFKPTMQEATNTLLTTEHKVKTPSLHYIGDLDTLVLPEKMLSLTEAFENPVIFRHMGGHYLPSTSTSQKALINFLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFQ3</accession>
    <name>A0A367JFQ3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PEX16_3</name>
        <name evidence="4" type="ORF">CU097_008480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001407">
        <property type="protein sequence ID" value="RCH88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFQ3"/>
    <dbReference type="STRING" id="86630.A0A367JFQ3"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="516" mass="59974" checksum="15B2619AC626E31B" modified="2018-11-07" version="1">MKWFQSRHDFNYEWSLVSAANWQKYPNESCTHVAHVDVLCRTIDPDTGLLTTERLITVNQHIPTLIRKILGPGTTQYVHEISTIDPKSKTLTMRSVNLTLSHLLKVEETIVYQEHPEDRKKTLFTQQAAISAGSLVSGWSHVLEEFSLRRFKQNADIGRAGFNKVLERFVGMQQQQQQQQQQHIESSLRSLTFILPGRFQDAELASQALYAALNLVDLYHNSIIRKAILARRDQVEESAFNKYIHFWSSRSNLNATASSLLSVILYTQVLIEMAVLKKYGKKRQWECIAYLEGLKVMLRLFIFQTTGQRMTLSPPHLQRDIDPQTLAIQPQEDNETWVGKRTGIRVKRMKDCFQTNSKSTDVTDFLLSRKLTADMLRKPDQMVTVQKNISKLGELMYILRPLIYVMAILKWGKRSWRPWIMSLAIELLSQAALKAGYRAASGRTRMMPLEKDEFHRRRRLLLLNVMRGIFYLKITRPRLESFCNRTEDKPILSLASNIIREYLPLWQDIYFYTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG60</accession>
    <name>A0A367JG60_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PRDX1_2</name>
        <name evidence="12" type="ORF">CU097_009847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001391">
        <property type="protein sequence ID" value="RCH88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG60"/>
    <dbReference type="STRING" id="86630.A0A367JG60"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="211" mass="23892" checksum="F05FDA5D7CB73EB7" modified="2018-11-07" version="1">MVIQIARVQKPAPPFRAPAVVDGNFKDISLQDYQGRYLVFFWYPMDFTFVCPTEIIAFSDRIEEFRELNCDVIAASCDSEYSHLAWINTERKKGGLGKMNIPILADKTKEIAKMYGVYIEEQGITLRGLFIIDPRGIVRQITINDLPVGRSVDETLRLLEAFRYTDEHGEVCPVNWQKGDKAIKPDVSASKEYFASLTAETEITATSTTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI34</accession>
    <name>A0A367JI34_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA-processing endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RCL1</name>
        <name evidence="7" type="ORF">CU097_002784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001262">
        <property type="protein sequence ID" value="RCH89587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI34"/>
    <dbReference type="STRING" id="86630.A0A367JI34"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="179"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="358" mass="39756" checksum="F9B28F3ABFA39574" modified="2018-11-07" version="1">MSSILKFQGYNYLRQRLILATLSGKPVRIEKIRSDDENPGLRDFEIKFLNLLEKVTNGSVIEISYTGTSILYRPGAIEGGRIQHDCGTERSISYYLEPMVALAPFSKKPFVLTLEGITTDHVDPSVDIIRTVLLPQLKRFGVDQNLELKITKRGAPPLGGGEIVFSCVPIRQLKPVQFTEEGRIKRVRGIAYCTRVSPQTANRLVESARSLLNRYIPDIYIYTDVYKGAESGKSPGYALSLVAESNTDVLLSAEKAAEPGQTPEDVGLMAAKLLLNEIRKGGCVDTTSQWLNILLMILAPEDVSKIRIGDLSAFTIQYLRDIKSFFGVSFKIQPDTSNDTILMTCMGIGYVNHNKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIU8</accession>
    <name>A0A367JIU8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001223">
        <property type="protein sequence ID" value="RCH89815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIU8"/>
    <dbReference type="STRING" id="86630.A0A367JIU8"/>
    <dbReference type="OrthoDB" id="2286999at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="368" mass="42267" checksum="09ABFC6A41A4BE87" modified="2018-11-07" version="1">MPNPMITQKPYVPRIQKELVPREKALLMQNEEDLDADQLTSSFVYLSSSTTNGSLFVEENGLRNYGQSLSTACETVTTSYNNYYIENFENIICNYFIYSLRRKYPNVKIGCLKNLVYNHVYDEVLVHSEPSSILDGILCLFDSDVASSLSSFLNPLILEMKNCMPTLPVSKYENLNMAQPSQDAKGSVSKFMPPRLFGIFPGAKQEKQINESPFDHNQRQFFQTFDFKKLGFRRRKNKTRFEEGDCKKMPLVIFSDSLRNKDHVKFKGLRRGVSNKICRQLKRREELGELLLLDINEYKPQRLTCNSCFKQELENLKRGGGDDVKKIHQNMLTIARSIWISHGRPNVFKRQLATSNVVASSHSGEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJK2</accession>
    <name>A0A367JJK2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">TIF32</name>
        <name evidence="10" type="ORF">CU097_009491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001174">
        <property type="protein sequence ID" value="RCH90118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJK2"/>
    <dbReference type="STRING" id="86630.A0A367JJK2"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="317"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="799"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="553"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="951"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="994" mass="114107" checksum="4E9826B3FBEC4F5C" modified="2018-11-07" version="1">MAPFYAVKSDNVLKRVEELQAVGEDEAALQALHEVVLSKRSRSNPITVMEPIMLKYVELCVELKKGKMVKEGLHQYRNIAQNTSVNSIETIINRMLELAEAKVAEARAKADKIAVDVDDLEASETPESIMLSTVSGDQSKDRTDRAVVTPWLKFLWEAYRTVLDIMRNNSRLETLYNAVTLKAFQFCLTYDRKTEFRRLCEILRNHFLNVAKYSHQPHAVNLNDPETLQQYLESRFAQLNAAAELELWQEAFKSVEDIHTLLTTSKRPPKPVMMANYYEKLTKIFMVSEDYLFHSAAWNRFCAIERAFNKNLTEAEHSRMASIVLLSALAIPIITTTKTRPGYVEADEYRVQKLNRLSMLMGLSGHPTRTGLLKEALHKNILARVRPEIRELYNILEVQFHPLSICKKINPIMAKLSEDPELVKYVRPLHQVILTRLLQQLSQVYTTVKLDFVLNLASFPDPYNYDAATIEKFIMNGCKRGELNIRIDHASQSLVFETDLFAPPKDTVTEGIQLQSSPADLMRTQLSRLGVSLNAALQMVDPSVKEEAEKAKQQVIQRALAGAEEEHKQALERKLIIERRKEIIENELARKEKLAAQEKAAAAAKKAEAEKKRLEEEAKRREEERLKRIQEEIQRDQAKRIAEEISSKTGLQLKPEEIENSDVKTLLNLKVSRLQSEQKELSDRLKQISKRLDHTERALRKEEIPLLEKDYEKQQKADKAIYEATRKAKLATAKEQHEENMKLKARFSRIIDDYRAYKSKLEEQRRQAVEAKQRVANEAIEKEKNERIALWREKIDELRQQREAEEEERRRREAEERERAEKEAREKAEKEAREKERREQEAERQRKLDEIARKQAEREAEIERKLQEEKAAKAKTIPGARTTGKYVPPARAASGDRYVPPARAASGDRYVPPRAGVSPGASSGDRFASFNRDRSAGSSGASGGRYVPPARRSDRGPERGPERGPERGSERGSERGSERADEASSWRRAGPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJN7</accession>
    <name>A0A367JJN7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_011161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001169">
        <property type="protein sequence ID" value="RCH90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJN7"/>
    <dbReference type="STRING" id="86630.A0A367JJN7"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="117" mass="13052" checksum="16E93DCA0CDF355F" modified="2018-11-07" version="1">MSVSNSQGINTLLDAEREAAKIVQKAKQYRVQRAKEARSEAAKEIENIKAQKNEEYQNFIAQNSGQSDQSLGKVDEETEAKIQEIRKAAAEKKQDAIELMLKSIVSVDPKPHVNARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJZ5</accession>
    <name>A0A367JJZ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_010843</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001151">
        <property type="protein sequence ID" value="RCH90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJZ5"/>
    <dbReference type="STRING" id="86630.A0A367JJZ5"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="49"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="204" mass="24047" checksum="B09883238D99F22E" modified="2018-11-07" version="1">MSYYGTLPTHTHEEEQEITWRHKLGEYLEDQKFHIGILCLTLVDAASVFIQIIYTFFHECHAPFNNIHDNTHWLIVAFEMAEVISVCICVLFILEIILSLIAFGPRYFLPGWSHWKLHVFDAAVVITTFVLEIVLKGKEREVAGLLIIFRLWRVVKVIEAVVLSMSFTHQEELEKLKERNEELQEKLKQVEQRNRELEQQVEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKE2</accession>
    <name>A0A367JKE2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001130">
        <property type="protein sequence ID" value="RCH90386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKE2"/>
    <dbReference type="STRING" id="86630.A0A367JKE2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="483" mass="54309" checksum="322CCB60B9843AA3" modified="2018-11-07" version="1">MSDPKVVETNETGFEDGQPYEMQTFANAAEVERKLVRTLDYRLMIWAFFGYFANGLDRNNMPNAYTTGLKEDLGLVQNQYNWALTMFFIGYIVLQIPANYIITKVRPSIMLPFVVFLWGAIVCFMALVKNYQGLYGLRICLGFAEAAFYPGIVFLLGSWYTKEELGTRTAVFVAGSQMSGAFSGLISGAISQHLDGVHGMRGWKWLFIIEGLIAVVIGIIGFFVLPDFPHNTSFIRGDMRELAIQRLERQGRSSTVTGLNWTTFRNLFTTPFIYLFTGMFICFQMGMGILQNFPIILKSMGYEASFANYMMVPIWIWVGVVIIAQGFLSDKYGKRPHHIMAGGLFTLVWYIVLVAVNGGHLPVPLLFVCAYMVPPVYGISPIMMTWANEIYSCDRESRALAIAIINSIGNLAPNFINVKVWDVSDSPSFRLGKIVTMAMTAAMVVMCGVAYFLDAKQIMIPKAPQRVKDIETNEKKPDHQDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKG9</accession>
    <name>A0A367JKG9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001122">
        <property type="protein sequence ID" value="RCH90428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKG9"/>
    <dbReference type="STRING" id="86630.A0A367JKG9"/>
    <dbReference type="OrthoDB" id="2222796at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016611507" evidence="1">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="205" mass="23565" checksum="F142E2D6D1832262" modified="2018-11-07" version="1">MKPNCALVYLTCLISFISTIYAIPIQQTSFQSNIQQHISTNDQTYPAIDQLEEHYAQIVSKVIDKTLNDLLENVPETFLTIHELQSLGKEYCQTSLFEFIQIIENELIKMKVDLIAAIYPLLQTKQDINAALIERINTDDLAYDIIHQLYATDLSILDRIIYTLSSRPFRLKQHHEANEALALRAWLSSWLMDIELALNQAIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKH0</accession>
    <name>A0A367JKH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_003330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001121">
        <property type="protein sequence ID" value="RCH90437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKH0"/>
    <dbReference type="STRING" id="86630.A0A367JKH0"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="149"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44732" checksum="3A45A12899719126" modified="2018-11-07" version="1">MVSSSFIKRFRKLDAYAKTLDDFRVRTATGGTVTIICGITILLLMLFETARYLTPVMKPEILVDGGKMEKLPIKFDITFPHLPCYMLSLDIMDESGEHVADYDHDVYKERLDPEGRVILTEKSNDLSNSAAKKARQHSPEVPDNYCGPCYGAKPQEECCNSCEEVQRAYADVGWSTDPDNFEQCIREGWKEKAQAQAKEGCRMHGTISVNKIRGNFHFSAGKAFSQGGSHIHDMSQFLHNDQNQNFMHFIKHLQFGQHEYHSEKQKRTKSNELIHPLENTKWGSANAAMMYQYFLKIVPTEFHFLNKKRIRTFQYSVSKQDHVVNYFGGLPGVFFMLDHSPMRIIYSETKMSLATYLTNICAIIGGIFTVASVIDGILYRAERISKQRKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM39</accession>
    <name>A0A367JM39_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001036">
        <property type="protein sequence ID" value="RCH90996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM39"/>
    <dbReference type="OrthoDB" id="2287607at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="69" mass="7654" checksum="8A2FE9FF00F4392E" modified="2018-11-07" version="1">MHPKCQSICARKATHSRDMVSATAIALAGLSTLLVGVSFPEFNPRKSQLDTDKFEDLAAHFPQKKRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPG6</accession>
    <name>A0A367JPG6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003416</name>
        <name evidence="5" type="ORF">CU097_007473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002324">
        <property type="protein sequence ID" value="RCH84596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000914">
        <property type="protein sequence ID" value="RCH91832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPG6"/>
    <dbReference type="STRING" id="86630.A0A367JPG6"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="27426" checksum="AE7062505AC34312" modified="2018-11-07" version="1">MGDAGFFKGTSADQDSRFSNKEKKLLKTMSFPPEFDKKVDMKKVNLDVIRPWIANKVTELLGFEDEVVADYAASLLEEENIDPKMMQINLTGFLENNAKVFVKELWNLLLSAQNSVGGIPAIFIEQKKEELRKKREREEAKRAERDSVMETIKRRRNEEMDDLKEERKSRFDHRSRSRERRRKSYSPSRSRSRSPRRHHRRHERDSYHSRHDDRHRHRESRRRRSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPI6</accession>
    <name>A0A367JPI6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000920">
        <property type="protein sequence ID" value="RCH91789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPI6"/>
    <dbReference type="OrthoDB" id="2242133at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="575" mass="67604" checksum="776BC625A2BFAD20" modified="2018-11-07" version="1">MEAQGTIWCNLPLEIWDHIMSYMNTDDLANYCLVSKAWYSICAPYLYQSIMIEDPDDLAVVLCNSPRAPGRHVKKIVLDYEGMSLEETYDQLRMLIDYCPNVEVFTSDEILTFLWWNSFLKVLQDGHVWRKIQKIPETIRESDNMDLYYQCSRHLRQSLQTIQLLGPRFGPVRDTDVCWLGDFPCLNSLEVYPRIGFATVQDFELLLKYTQHLRQLTVDWHDFGLSQAELEWLEATQARQMPRIDIYPSMECLRVTGCFSFDSVYMPQLCYFLQKFPRLKTAQLTIHSANMFDNIFTQYISRTPHVVIKVRYATILLQVLSTFVGLEYQKVLELEYAPEFHYLRQMVVRLKMTKNEVHCSIIGELEDDFLSSVSIDILQTIGFRIHHLTIEHPFRIWQGFNLGIYGDLCPRLQTLEVSYVEVEQFALDVLEEHRELRHIKLIDSVINNDAIFSALSTLVPNLETLVLENCTFFRERAFPFTLVMDMPHTRFSHHLHIDLTNVDFEKILLRLSIGTKRSNYYLCQDNGTIQVPNFVVQELYANYHPYVATLFIRCQSLRRLELTLPDEEKNIVCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPT7</accession>
    <name>A0A367JPT7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_005935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000896">
        <property type="protein sequence ID" value="RCH91964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JPT7"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="532"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1340" mass="152332" checksum="F17393B6A93B7464" modified="2018-11-07" version="1">MPASDKKQTKKQVEQEESDSEELCFICTEPVITYAVGECDHRTCHRCALRLRALYETKNCTYCKAEQTVVIFTKEAEKPFDDYVESDTPFVDKKLNIKFETQDMYRDSIHMLKHNCPEKDCAECSDNWPELKLHVRKEHNLNFCDLCIDHKKVFPFEHILYTSEQLIQHYKEGDKKFIKNDESGFSGHPECQFCKKYFFGSDELYVHCRDNHEQCFLCVRNGVRHQYYVNYASLEQHFKKDHYMCLYPQCLEKKFIVFDSSIDLIGHEVEVHGESTSGLQRSMQMGARRIDLNFQYDQPRPSRANGNRSENTRSNSTGTSSNASLSANDFPSIQRTAGSSNVTVATQSRAVPGASSRKKDKQKAVQKPTGFGALSPVETGSPSTSGTVTPNATGSSTVESPVVASHAAFLAKLEDILQSKQKVTEFRKLTGAFRKGTIDADAYVNQVVLLTNSHVEKSNKIFKGVENLLDIEEKKWEMIRAWRNKHTAMTQFPALESSGRPSSSTIKKSRVLVIKDTKTNKPNKSVQKTAWSSSNGSSRSSSSSTTTTTTATYSKSTKKSTSNSNNNNNNNNNNGSSTSRHGSPTSTPSSSTPTLLENQAFPSLPTAAPKHREVLNIRRSTQRTQNAWDGNTSQIEEDDQVIDSSIDKKKKKGRKNKVQKQITPPPNLPLASNSTYIVIGLFNISTNFQQDVFTTKIEQMLIELNRLVNQAGDIPFSLLPPHHDVILVMRQIPLLINQSSTPLLLYSVVERVMCQLYQSTTPLAIEVYCRFLQILMDLSATVSKDILSWILYSDDPRKYNARVMSALIKSGLVRIEEFDTQLSKQLDQSQDPQLIEFAVTLLRLCMFMLHPISSIDDHLLTIRALMRLDHTLAKELIQELEGQWTAKYRNPKNDTFALRLLFAEWIRLYKHALTASSTYHQFAKKIMKTVTNNPDRMCFFFRLCTEVCVELYQSTKSHCIDAYSKLVNNIIQINQDSIKISCQVLSITVLVIAEHHEKLGTQFNQKPFLKLLGSLFIELNNVNDRESFIGIYGDVLYTLRPLKFPGFAYSWLQLFSHRLFLPLLLKEENEGWTICYKLMSALLSFITILLTPTEEPARLSRSAKAFYQGSLRFLVVILHDYPEFLCEHYFSFIQLLPLSCVQLRNVILSAFPRTMILPDPFTISLGYVANNTTKPKLLQMKEEDALIEIGAYLTTKQSKMSIGSSLVSYISSRDEKQPCDVERIQRLVFYVGSHTTVDTKKPLSENPAIQIYKYLLAYFLSTGNSFGQYALLNCIADHLRYPNSHTHFFSMAILHLFNSQSQQIKEQITRQNITRKTDSESTSPMGPVNNICSAHQRVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR45</accession>
    <name>A0A367JR45_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000830">
        <property type="protein sequence ID" value="RCH92424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR45"/>
    <dbReference type="STRING" id="86630.A0A367JR45"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="18835" checksum="EF6E8A157E69858D" modified="2018-11-07" version="1">MSPMLLPRLKNGIKERSTFWDIFSFAGPPTFGFDEMHSVARGIDNLVYELITVDKTGEDGFFHTRPDESKVISSYPFLITKQNLVAIGKVMAKSAWNILTSFEGSFQDLVNKTSGTHAVDWLDFLFCIVPTLIVPLIQSNAAKQAILSLVKDCSLAMQWEITEESNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR62</accession>
    <name>A0A367JR62_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1264-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000866">
        <property type="protein sequence ID" value="RCH92181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR62"/>
    <dbReference type="STRING" id="86630.A0A367JR62"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25460" checksum="6773806263567CCC" modified="2018-11-07" version="1">MCSEQGKTSTLKAGMELASSPLISFKPMGGICESFCGIHPYCNDTNRQVIAYHYCHMIDEDRRQCLVYDSDSVDAKLIAVEYIISEALFKSLPEQEKKYWHSHKYEVESGLLCMNAKSLVPDAVTSTIEKGPLEILVNTYGKTWQLWPVDDDGNCSSKVPLGPPQLMMAFTADGQVKPELVERRDKQMGISTEKKRAERKDVIKGNPVAEGADHWEKGKPFQIPTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSB4</accession>
    <name>A0A367JSB4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CCT3_2</name>
        <name evidence="13" type="ORF">CU097_010159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000770">
        <property type="protein sequence ID" value="RCH92862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSB4"/>
    <dbReference type="STRING" id="86630.A0A367JSB4"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH92862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="60112" checksum="15CB7B90DCA311FC" modified="2018-11-07" version="1">MQAPVIVMNTNMERESGRKAQLSNITAAKTVADVIRTCLGPRSMLKMLLDPMGGILLTNDGNAILREIEVDHPAAKSMIELSRTQDEEVGDGTTSVIILAGEVLAGALPHINNNIHPVVIISAFKKALEDALAIVEEISTPVDINNNEEMTNLIKSSIGTKFTSTWSDLMCKLALDAVRTVALKDESTNKMEVDLKRYARVEKIPGGEIEQSQVLDGIILNKDVTHPKMRRRIENPRIILLDCPLEYKKGESQTNIEITKETDWNRILQIEEEQVKAMCEKIISLKPDLVFTEKGVSDLAQHYFVKANITAIRRVRKTDNNRIARAVGATIVNRVDDLKESDVGTKCGLFNIDKIGDEYFTFLTKCQDPKACSIILRGPSKDIINEVERNLQDAMCVARNVFFSAKLAPGGGATEMAVAVKLEEKAKLIEGVEQWPYRSVAEAMEVIPRTLVQNCGGNAIKTLTQLRAKHTAGEHSFGIDGEAGKVVDMKDYGVWEPSAVKVQTIKTAIESACLLLRVDDIVSGLSKNKQMAPQGAAPEAMEQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSC3</accession>
    <name>A0A367JSC3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">B(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000784">
        <property type="protein sequence ID" value="RCH92749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSC3"/>
    <dbReference type="STRING" id="86630.A0A367JSC3"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH92749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="61320" checksum="27263D55A9B1B634" modified="2018-11-07" version="1">MPTNNLDNHEEGVLGSDSEDSLFSTGSSHHFDNDRDDQSLLPLTQHANTSTTSVFSFETIPMIPLSQTQTRGPELQKKVSLLNGLGLVVGMMIGSGLFSSPGPVLESSGAYGTALVVWFISGLLALCGALCYAELGTMLPMNGGETVYLGRAFGSLVSFMFEFITIIVQKPGSLAIICIVFGEYVSRIAYHTYFFNIPHDSDDAVELADAIIPKFLPKLLAVICLFILTFINAISVQAGIRVQDLLTAIKVLTAIVISITGIVVLSKREPIYGDSSIQGDPFHGIGSISYGQIALAFYSGLWAYDGWNNLNYVSGEMKNPHRDLPRVIIFGIPLVVFCYMLSNVAYLAVLRPEVVMHSNTVSMDFGKKIFGPSGGILFAVCVALSCFGSANASVFTGARIIYVSAKQGHIPGLFGKLSQSRQTPILALLLQAALTVIMIMIGSFRVLVNFYSLTAWIFYFLAVFSLLIFRYTEPDLNRPYRVWLSTPILFCLVALFLCTTPFIEAPIESLIAVGLILLAVPIWLLHVKFGNKISKGWNYITLRFNKNRGYHGVEMTEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSD1</accession>
    <name>A0A367JSD1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000778">
        <property type="protein sequence ID" value="RCH92795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSD1"/>
    <dbReference type="STRING" id="86630.A0A367JSD1"/>
    <dbReference type="OrthoDB" id="2280694at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF13">
        <property type="entry name" value="OS09G0290500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="2">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="343" mass="38706" checksum="46A1A0F394E885F2" modified="2018-11-07" version="1">MKVECSKSSELISEVNSQPLHPVTDLQSPSKRLVINPALSELTQQTLIDVNSQPFSLKDNNTLVTYQEFGNPNDRVLYYPSEGSSTTQTSTEATTAAATDMVDNPAMITEFYERFATGNMFPSLADLRTAAYEYGKKYNVALTTSKSDKTKVYLICKHGGHYRQNEKRDKKKTEIAVPDKEVKPRVRRSQKTGCECMIYARCSRDSFWMIRKSVAEHNHPIAEDPRTYAMYRSLSPENLLIVHRLLRERVGVSYIVKSLRASGVTNVIAKDIENIQQDMKRRDTLNEQLQLQSAVIQAGLPITEQTSTFTTDPSSSSNPSTATTEQQQQQQHNSKDNDDNAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTM8</accession>
    <name>A0A367JTM8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GLK1_3</name>
        <name evidence="9" type="ORF">CU097_006415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000727">
        <property type="protein sequence ID" value="RCH93209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTM8"/>
    <dbReference type="STRING" id="86630.A0A367JTM8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="213"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="458" mass="50627" checksum="9478FA90BF9B55B2" modified="2018-11-07" version="1">MTQDIFSLVEKEFLLSKEQLKPIIEGFIQEYKTGLKTPSKGLATMIPSFVTKMPMGNETGTFLSLDLGGTNLRIAAVELRGAGKTTVHELKRCPSTELKTGEGSVFFDWIADAIQELITVEARHLFSTAQVEGKETLSLGVCWSFPVDQTAVDRGTILRMGKGFTLKNTEGNDLADMFHEAFQRKNLNVKVTAILNDTVGALVAHAYRNPACRIGLIFATGINAAYPEKVPAITKLNPEIRRRYPPGTEMLINTEIDIFGTEAYLPLTKYDLALDCSHNQPKFQLYEKMLSGAYMGELTRLIAMDFIQAGALFGGEVPEGFDRPWSFPTKYMSILENDETETKEASFDMLSQFPSRHGKPTMEDITTLTRLCRIVASRSASLAAVAIISLLEQQELMGQENVVIGINGSTYEFYPHMDKRVRQALDEWYGPEVSSKITLEVASEGGSVGGALIAMLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU76</accession>
    <name>A0A367JU76_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Karyopherin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CRM1_2</name>
        <name evidence="8" type="ORF">CU097_007969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000722">
        <property type="protein sequence ID" value="RCH93241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU76"/>
    <dbReference type="STRING" id="86630.A0A367JU76"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1068" mass="123140" checksum="4E0A2AF6A41D4DC5" modified="2018-11-07" version="1">MAESILDFNKELDIALLDQVVLTFYTGSGSNQQMAQQLLTQFQDHVDAWTRADKILEHSNVPQTKFIALQILEKFITTRWNTLPIETKQAIRYFIVDMVIKSSSDEATLYNERTFINKLNMVLVQILKQDWPYHWPSFIPEIVASSKTNMTLCENNMNILKLLSEEIFDYSAEQMIHLKTSNLRQSICNEFSEIFHLCVEILDSVSKPSLIKATLETLLRFLSWIPIGYIFETNLIQLLTKFLDIQQYRNVTLKCLMEIGSLSGVDEYNEKLISLFTQVMGSINTAIPPNADIASLYENSSNDDQQFIQNLALFLTSFLEAHVEIVERTSECRDLLNSAHIHLINISRIEDREVFKVCLEYWTKLVRSLYDETANLRLYNHSIHPTEVQPWSRKSIYADILSSLRVVMIEKMVKPEEVLIVENDEGEIVREFIKESDTIILYKNIKEVLVYLTNLDVADTEMIMTKKLQRQMDGSEWSWQNLNKLCWAIGSISGAMNVDTEKHFLVTVIKDLLSLCEQKRGKANKAVVASNVMYCVGQYPRFLKSHWQFLKIVIHKLFEFMHETHEGVQDMACDTFIKISQECSRHFIIQQTGEVSPFIDEIIHNMEDITCRLTPQQVQTFYEAVGYMISAQSNKVIQEKLITKFMSIPNMLWQNAILSVKNSSMILKQTQQLKILTNILKVNIAACSSIGHGYISQLGVIYSDMLELYHTAEMIIIQLLAEQGNIAVKTPNVRGLRSVRKDILQLINTFVGCATDLDSIQQNMIAPFFEVVLTSYSSSPDIIKEAYVLEVLANLVDKLDTLMMPHIPLVLESTFEPTLNMITKDFTEYPEHREGFYHLLRSINRHCFPALLELSPDRFKLIIDSIVWGFKHTLRHIADLSLGICEELIQNINATDSTIADAFYQSYYLSILQDIFFVLTDGDHKSGFKGQTEMLALLFSLVTTNSITMSLYNPSETTDENMDNVKFLKDYVSTLLQNAFPHLKRGQITVFIDAMLEYNNTLPKFKLEVRDFLIQLKEFAGENTELYLEEKEAEIERKRREERENALRIPGMIKPSDLSLMKEDEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUE8</accession>
    <name>A0A367JUE8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain and PHD finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BRPF1</name>
        <name evidence="6" type="ORF">CU097_001207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000713">
        <property type="protein sequence ID" value="RCH93311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUE8"/>
    <dbReference type="STRING" id="86630.A0A367JUE8"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="5">
        <location>
            <begin position="290"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="47303" checksum="52662A9CDB6E63E7" modified="2018-11-07" version="1" fragment="single">YRLMELDKKDIFKHPVTEDVAPGYNDIIQEPMSFSEVLKRLACHFYTDFDTFEHDISLIWKNCMTYNNPDTSYYKLAQRLQKASNSLIAEAKEAYDALEIDRQTGFLDTPIDPDIFAFGREPSQFEKENHGIELTSLTNEENDTKEKQDHDLTEKTNTTDENENSIYQKHGSNEAVLEPQKISRKRRSASCDETPVKKRKVAPGIQPSAAPRLTRSKANEKKRSLRSFSMSKNTAERRSTDSSILKRKTGPEFLKIDHQKKRIGRSKDKKTSLKNIKPLASVQLKLQYKDKEIVWARVPGFPAHPAQIVDERKHQDIPDNVLILKSRPDYKNKVLVKFFAVSDLHTWGWINKLDIEPLGNKEIDMKMLLKAKRTKKTYRINEIKKGYQHACKLKHIDPLPFLNLVFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUM9</accession>
    <name>A0A367JUM9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AKR1</name>
        <name evidence="14" type="ORF">CU097_008624</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000675">
        <property type="protein sequence ID" value="RCH93618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUM9"/>
    <dbReference type="STRING" id="86630.A0A367JUM9"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="434"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH93618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="676" mass="75458" checksum="456B18DB895C9878" modified="2018-11-07" version="1">MTSIEDKKPLLIDKEVLSSAKKPTTSVTSTEATANVVAEQSMTIFEAAQKGSFQTVRYLLDNKLATVHDVDSHGATPLHYATLANNDVCLKYLIDRGAVVDAPGGELQATPLHWATRQGRLAAVHRLIREGADPSKRDSQGFNALHLAVHSSHAMLVLYLLYLDMDVDVTDDVGGHTPLMWAAYQGFAQSVELLLRFGANVAATDHAQLTPLHWAAVRGNKMCIKKLLEYGADANARGQDGKSVMDFVRENKVEKVWERAVLELDVYAQENPAHASLVGKYPGSKGKPLSKRTVNTIAYIFPYITLGLVLKCLATFPWYTGLPLTLLLCAAMHLTIVNYVVPIPSNDAVWRTPYFSSIFQASAFWVLVTWIRILLPSTSQWLFTHLLFIVAFFTAMFAFFKAVSSDPGFVKNDLSREKQRLAVEELANDNCLDARHFCLTCLVKKPLRSKHCNICNRCVARFDHHCPWIFNCIGIKNHRSFLIYLVNMVIAIVTFTVLSLNYLSISSPIYDHKVDSACLIGSTVCGYFDYDAWTLSLTVWVLFQLTWTVFLLVVQLYQVAVGTTTNESANINRYAYMNANTSLIAAGGGTAGTDGPSISEEAGPRHHHHHKGSFCPCLQLVAGAHAVHKARRHTRKGNVFDHGCWNNCLDFWLEPNAINYYELYDIQQLRKRTEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUS0</accession>
    <name>A0A367JUS0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000668">
        <property type="protein sequence ID" value="RCH93680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUS0"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF1">
        <property type="entry name" value="INHIBITOR I9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016578647" description="Inhibitor I9 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10760" checksum="758A876A48067D9C" modified="2018-11-07" version="1">MKIYLLTATLLLLYATLVYADYKYILGLKSDATDEEYKAARKNIESMGGKVTYEFHSTMKAFAFTVPDNTIATKEQPAFVDFLEEDKTVHTYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUU9</accession>
    <name>A0A367JUU9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000696">
        <property type="protein sequence ID" value="RCH93451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUU9"/>
    <dbReference type="STRING" id="86630.A0A367JUU9"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF8">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="47"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="243"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="46588" checksum="FF377201BB0FEC72" modified="2018-11-07" version="1">MNPRLIQRRWYTSTSFKQLGLSLSTCQRLQTQFHVTQPTRAQQEFIPHLLAGKRDLLLRDATGTGKSFGIALSLASLVPATSGCVHSLYIAPNQELATQIGQWIQQLTPHAHQVQVIATSLTEKPPITHTVVGTPNRILEYINQGQLPVHALDRLILDEADQAFALPRKYAPLREKERRARHPKPAEQLLEKIKHGKHRTVITSATLNRPLRFFLSKRGFVRDPLFVDLQTTTVGVKHHCLLVSDDRIRNIRPELIKQDLDMKQKLDFDDTDDRLIESIATLHEIESVSNGILFIDSTISVEAIKERLAEYQVQAHDIKEYSSLGPQPGALWVATEFTARGVDIPGASHVFILGKPSSTAAYLHMAGRTGRLGPSGFSQGKVFSLVRDQGWTEAKMKNMFELLNIPVEHYEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUW5</accession>
    <name>A0A367JUW5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PT3</name>
        <name evidence="10" type="ORF">CU097_012248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000657">
        <property type="protein sequence ID" value="RCH93772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUW5"/>
    <dbReference type="STRING" id="86630.A0A367JUW5"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="523" mass="57635" checksum="39E83B9C4998EB65" modified="2018-11-07" version="1">MSELNTETILTAKERRRLALEEIDNAKFGWYHIRACLVSGIGFFTDAYDIFAINLVSTMIGYVYWPNEGNKTPHDIDTAIKVSCSAGTVIGQLLFGWLADRVGRKRMYGVELMIIIIGTVGQTLVGNAPAASFWAVITFWRVFVGIGIGGDYPLSSVITAEFATTRHRGAMMAAVFAMQGIGQVTASLVGMIVTAAYKSAIEADQMYLDYVWRIVIGLGAVPAVCALYYRLTIPETPRYTMDVEHKVSQAEQDARKFLRENGKPIPSSSSSSSSADTIQPKASWKDFFRYFGRWRHGRVLLGTAYSWFALDVAWYGLGLNNSIILQNIGFAGGPDAYNAVFRTCVGNVIINLLGSVPGYWISVFTIDKMGRKTIQIMGFTMLTILFVILGFGYHAIIERSVVLFIVLFTITQIFFNWGPNTTTFVVPGECFPTRYRSTAHGISAASGKIGSIIAQVAFGLLKDIGGPNAWINHLLQLFALFMLTGLLSSFLINETKGKTLEELSQEENADDADQNSVTDDLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVW4</accession>
    <name>A0A367JVW4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="4">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_012420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000626">
        <property type="protein sequence ID" value="RCH94038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVW4"/>
    <dbReference type="STRING" id="86630.A0A367JVW4"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="11">
        <location>
            <begin position="51"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25249" checksum="9E86C7E6243EDE99" modified="2018-11-07" version="1">MTGLSKQEINRIADKATTAVEVDGMSWPSLGAKKRRDETAEERVERENKIADAVKIILECIGEDPEREGLLKTPDRYAKALMFFTKGYEQNIRDVVNEAVFEEDHDEMVLVKDVDVFSLCEHHMVPFMGKIHIAYIPNRRVVGLSKLARIAEMFARRLQVQERMTKQVATALMDILQPQGVAVVMECSHLCMCSRNLVAQPLRAVCWECLEAIQEQEKSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW52</accession>
    <name>A0A367JW52_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000619">
        <property type="protein sequence ID" value="RCH94089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW52"/>
    <dbReference type="STRING" id="86630.A0A367JW52"/>
    <dbReference type="OrthoDB" id="2289277at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="35569" checksum="F16DB29B87310106" modified="2018-11-07" version="1">MIDCSSAETAAIRDVFEGSVQILLCHWHIWRAWDNEEQFLAYFRTRWLVKKELSCKAWQPSASFHMNNLIEPYHNQLKTFYPGRARRSRCDFLIYTLQETLMIDYRQETLKCLYGFQTVKLSPSDMKKKRLAYAFDEDTATSMVRRSEDDDDIYDCKPFTDNYIWHEIELKNGHLFRCNCPDDSKLCKHIFLVNRVTDVPYTLHSDVVVEADATGLNHNELAVTGINFADITNNSTSDNDICQELADSIDRFENLYISDLRRKKVMYSLQRDKLEVINHAAKTSYYMMKEAAVIPQTLPEHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWH6</accession>
    <name>A0A367JWH6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000589">
        <property type="protein sequence ID" value="RCH94334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWH6"/>
    <dbReference type="STRING" id="86630.A0A367JWH6"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017049606" description="Trehalase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="612" mass="69957" checksum="7CE7E7852682F2DA" modified="2018-11-07" version="1">MLRSLCGLLLAQLTVSVMAVHPSSHSCDSPIYCEGPILKTVQLAKLFPDSKTFVDMPTLKPESEVIKAFNAMGGTNATKNQIEQFVKENFLDAGAELNMLTNVSIKEELGWIQDIPNPKYRGWINHLNHAWTNLTFEFDYSKLCPDCSTSTLPVKRPFVVPGGRFREFYYWDSFFVIKGLLLSDQDTLARNMIENFFDFIDEYGFIPNGARIYYLNRSQPPFLSLMVNAYYEKTKDEDFMAHALPYLDKEYAFWMTNTTVEIKSPNHPQKTFTLNHYTTKNKSPRPESYVEDYKTVDGDVHYPDDVKDRMYADIAAGAESGWDFSSRWTRVKSPSPHQVANYEMLRTINTQNVVPIDLNALLWYLEDSLSKWHKQFGHGKESKKKSRHYAQQAKTRLEAMDKLMWNDDHYSFYDFNLTSNAQNIEFTPANLYPIWLEAIPNHLRTNKTKLSHTLDAAEEALRKYPGILTTSYYNTTMQWDWPNGWPPLTFIAIQSFMNVDALLDSKYTTRYGTSYSELAQVLASRYAASAFCGWYKTGGSVPGVLPKIASTSDEGHMFEKFDVTAIGTAGGQGEYTPQVGFGWTNGVAMWIFNTFDNLTAPADCNQNITINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXL6</accession>
    <name>A0A367JXL6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GAS1</name>
        <name evidence="8" type="ORF">CU097_013912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000550">
        <property type="protein sequence ID" value="RCH94686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXL6"/>
    <dbReference type="STRING" id="86630.A0A367JXL6"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF10">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016481976" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="7">
        <location>
            <begin position="369"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="519" mass="56779" checksum="40F4D660E95CD248" modified="2018-11-07" version="1">MKISVIIALLFTAGSSFALNPIVIKGTKFFDSVTKEQFFIKGVAYQPRGQVKDGTMDPLADPAACARDAPLMAKLGTNVLRVYEVDPRRDHDACMKSFANAGIYLLLDIATPHYSINRKAPEYTVHLYNAYKSTVDAFAKYNNLLAFIAGNEVTNDKTNTLASAYVKASIRDIKQYIQSTHNRQIPVGYASNDDEFIRDPIKDYFNCGDEDTQADFFGINLYEWCGTSSFEKSGYKERTKEFETYSKPVFLSEYGCNLVTPRQFAEVAAIYGPQMTNVWSGGVVYEWTQENNKYGLVKINGDGKAEELQDYHNLQAQMLNAKPKGVHMDNYNEQRSASACPEISENWKATAQLPPTPSDGACECMVENLACVASDKVEAASRQAGNSTIGAQLDIMCGITSCADISGDAEKGEYGAFSFCSPRDKLSWLYNLQAMQTKSCQNEGLGQEVVPKRHDIQTCANIAPNFNSPIGFPSASGPSTSASSSSSPLSSFSLVSATIQHGGVFFASALFAMIAVLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXP7</accession>
    <name>A0A367JXP7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetoacetyl-CoA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000553">
        <property type="protein sequence ID" value="RCH94659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXP7"/>
    <dbReference type="STRING" id="86630.A0A367JXP7"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05943">
        <property type="entry name" value="AACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="75286" checksum="ACA4371C7B8C38BC" modified="2018-11-07" version="1">MSIVSEHSLSTEPKCLWKPSCPEQTEMEKFRSLMQKKYTSAKLGNYQELWSWSVQNPEDFWSEVWDYTKIVHTTKGDQVLDNSVPMDNIPEWFKGARLNFAENLLWCKSKDKTAIIATGEGHEKRFISYAELNDSVLRFASALKNLGIKKGDRVAAYIPNCPEAIIAMLAATSMGAIWSSTSPDFGTTGVLDRFSQIQPKVLISVNKVIYNGKTLDHLSKLKTVVEGLPGLQKVVVIPFVGQVTQEELKDIPQSISWDDFNNSVPQDTLPTCIQFEQLPFNHPAFILFSSGTTGLPKCIVHSGAGLLLQIKKEHVIHGNMGPDDIFFYYTTTGWMMWNWLVAGLSVGSTIVLWDGSPFKPAPISLWELVDELKITYFGTSAKYIQSLQEANVHPKEQCKLDSLKAIYSTGSPLKPESFDFVYEHIKSDIMLGSITGGTDICSLFAGQNAALPVYRGEIQCVCLGMNIQAWADQDKPVFAQAGDLVCVTPFPCMPVEMYGDGPERAKYKSAYFSVYPHVWYHGDFVWINPKTGGVVMLGRSDGTLNPSGVRFGSAEIYNVVDRFRDDGVEDSLCVGQKIKNEDDERVVLFLKMKAGHKFNEDLVKKIKVTIRSELSPRHVPAFVLPITDIPYTINGKKVEVAVKKILSGQKVMATGTLSNPESLEYYYNIPELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYL2</accession>
    <name>A0A367JYL2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000544">
        <property type="protein sequence ID" value="RCH94741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYL2"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="320" mass="36875" checksum="742C30FFAD8EEBBF" modified="2018-11-07" version="1">MGVAISRDPSLTTTNNNNIHYAKKLKTVKQNKEQEKRLTSRIIYGREYHAIENSTYMLPKDDKEVDRLHDQHFIIKELLGFNIMKEAFHLLDFQKSNLNILDVCCGPATWLCEESLEYPSCQFTGIDMCSLWPQVIRPANLHFTEANILQGLPYPDNSFDFVHMRFVVLAFKSKEWPFILSEIKRVLKDGGCFQCVEVDMRINITTIDNVAKTYMEAFESFCESYQLDPSVAAKYDTMLVDNGMKIVQSNYREVPLGWGGPVGHAYLHTFQGILEGLAPWLKKSLNIEQDENYHILLDTIKRALVRSRAFIGLYAFLAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYS7</accession>
    <name>A0A367JYS7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000503">
        <property type="protein sequence ID" value="RCH95080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYS7"/>
    <dbReference type="STRING" id="86630.A0A367JYS7"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="11"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH95080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="473" mass="52713" checksum="AA5DB8AFF0217B89" modified="2018-11-07" version="1">MKGTSQRSKVRGCITAFTAMISPLTANIYLPALNQIEQSFNITTEQVNLTITVYMIFQAISPTFWGTLADSIGRRPILMSTMTVYCGACIGLALAPNYASLMVFRMLQAFGSSSVIAVGAGVLGDIADSKKRGSYFGVYSIGQLSGPVYGPVVGGAIAQNLGWRWIFWILLIISATSLVAVGLFVPETLRSLVGNGSGYANPTPWQWIARRRGNLDEKRIQEIKERNPKRTRMNFLKPFMYLLEPDVFVTLLYNGLHYTGIYCSLASMTKQFSIHFPFLSETNIGLCYLSQGCGSILGSYTRGKILDYDYKKVRNAFREKHPDRPEWDMPIFKARFRTIFVNVVMCEVITIFYGWCFEWNARLPVILVLQFFVGFGTGGIMATTQTLLIDLFPGKGASITATNNLVRCILGAIATVCIDPGISGIGMGWMFTIVGLILVTSNICILVLFIYGPTWRRNRIDRQLMKEKEKMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ67</accession>
    <name>A0A367JZ67_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ca(2+)-dependent cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCA1_5</name>
        <name evidence="6" type="ORF">CU097_007222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000481">
        <property type="protein sequence ID" value="RCH95292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ67"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="169"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="467" mass="51571" checksum="823AC5E485D9096D" modified="2018-11-07" version="1">MAYPGSYGTHPYGQSNQQNQQYPPPQYPPPPQQYGGYPPPPSYGNYPPPVQQSQYPPPQPQYGNYPPPPQHGSPSYGNYPPPGSGPYSTPQSSAHINPPAYTGPDPIFKPTDPTLTQANYPQPPHSTHNPAPVPYGQPQGGAGDFVMHVNPVMQNQAPPNFQLSNCQGRKRALLIGINYFGSPNQLNGCINDVKNLKEFLTSNYNFRSEDMVVLTDDQTDPRFIPTRENILKAMQWLVHDARANDSFFFHFSGHGGRIKDTNGDEDDGYDETIYPVDHDRYQGESGQIVDDEMHEILVRPLPRGCRLTAIFDSCHSGTALDLPYVYSTQGVIKEESMFKDAGAGILNAGLAYAMGNKSGALSSVLSLGKSLMSRKSVDERVKKFKSSEADIITFSGCKDNQTSADAMENGKSTGAMSFAFTTALRQNRQQTYLQLLNSIREILRSKYSQRPQLSSSHPIDVNLLFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZR5</accession>
    <name>A0A367JZR5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEAT repeat-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HEATR6_2</name>
        <name evidence="2" type="ORF">CU097_000676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000465">
        <property type="protein sequence ID" value="RCH95454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZR5"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="424" mass="48235" checksum="5416E83A6AF1B5DD" modified="2018-11-07" version="1" fragment="single">IASMFNTKQESLKELIQSDLIDTALLDAVKQQEDDAICSEGWHVCSILTKNYFQDTMPALWNKLVFEFDHVLPVSSASLKFFEAYASAIAEDVKDNQVKPEYVDWWRTIIEKYSQQASTGSSAIRAASCDCFASMSRDIFECLGYREQRLIVTLLYPLASDTDHNVRAAACRALGVFVLFPSLREDPLFVSDMMKAILEQRNDKIILVLVRSSWALANMCDALVLESEKEGFNLREYMSTSEWIDVLSYATSAATDNEKLRSNAVRTIGSLLRITPREYFENTRIVSLVSHAMDGLVKNIESGSLKTRWNACHAASNAFLNPYFPIGYVEEEAEGRVYPWTHHIYEALTQSLVECKNYKVRINACLALSTPKSKEKYGDKLEMILSCIKEAWNKCQASEEYSELKYKTQLENQVSNRIKILEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZR6</accession>
    <name>A0A367JZR6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Long-chain fatty acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FAA4_7</name>
        <name evidence="6" type="ORF">CU097_014465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000497">
        <property type="protein sequence ID" value="RCH95151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZR6"/>
    <dbReference type="STRING" id="86630.A0A367JZR6"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="152" mass="17191" checksum="1703202F958F0E8B" modified="2018-11-07" version="1" fragment="single">MSVAISEKLPGEGQIRRSILAEEEIVDTPAQGVHTLYDVLQYCVKRRGDKNAFGYRNVEKIVSEEKEVVKVVDGVETKQKKIWNYFQLSPYHYITYKEASDMAHQLGSGLVHLGLSTHSKIEIFAPTNVNWMLMAHGAFTQNMAIVTAYETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0A3</accession>
    <name>A0A367K0A3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Suppressor of loss of ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLY41_1</name>
        <name evidence="7" type="ORF">CU097_012983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000478">
        <property type="protein sequence ID" value="RCH95331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0A3"/>
    <dbReference type="STRING" id="86630.A0A367K0A3"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="16681" checksum="BDCA75A394F6FC10" modified="2018-11-07" version="1">MNMMFYSSFISFTLMIPLWIYSDGYHLLSGNHDNSQGINMTLIGYFLLNGTTHFAQNWFAFTTLSLSSPVTYSVASLVKRIFVIVMSIIWFGQTVSITQGLGILLTFLGLYMYQKAKQEVDKRESKLNNIELLPTTTAITNNNNKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0Q6</accession>
    <name>A0A367K0Q6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CDC23</name>
        <name evidence="9" type="ORF">CU097_009120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000432">
        <property type="protein sequence ID" value="RCH95784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0Q6"/>
    <dbReference type="STRING" id="86630.A0A367K0Q6"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="11"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH95784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="564" mass="66557" checksum="C7D3EFE62BEF5764" modified="2018-11-07" version="1">MILTDDSIQAFKVQLQQSIIVCSERGLFYASKWAAEVLNGIKDDFLDDKVPFTQNEVHIPTISTYHTDYESSLPPLSERDYNLYQYAKTLFNIRHFHSVIDVLGQSKHPKLYFLRLYAKYLAGEKRKEEFSQDVLGATEQTRADNAELESIYRELHEDYEHGRLDAFGLYLYGIVLKKRQLAFRAAAILLESIRKYQYNWSAWVELATLVQTKKMFMDLRALLNREFETSVMKEFFLAKLCIDLNQPGNFFKDIMDPLDQYFSRSAYVLSQWATFYYDSMDYNESLVLFEELRNSYPSRLDDMDVFSNLLYLQNLKHKLCALALECEKIDKYRPETCCVRGNYCVLKHETAESVEYFKRAIKLNRSYHLAWTLLGHSYFELQDLSAAIECYRRAVEVNNRDYRSWFGLGQVYEVMKYPYDALYYYHKATNLRPRDSRMWAALSGCYEVLKQHDEALNYKHRAEACDRLKDRSEMVQIAEIFKRRGRLDIAIDFYHKIWQRSIQENAIDEVTADISIQLARYAMSKNQLYDAEQYAITSLNMSHPYHEQARDILDEIGRLSKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0V1</accession>
    <name>A0A367K0V1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000427">
        <property type="protein sequence ID" value="RCH95833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0V1"/>
    <dbReference type="STRING" id="86630.A0A367K0V1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="488" mass="55790" checksum="90ACADF8424F4EEF" modified="2018-11-07" version="1">MTTFNHHSTNKRRDPPKSTESKASQWQHWAEEQTDSAYEKESNQRSLHIRHAHKPAKEILNKILPSLPLCFCNKPAYRSFTLEYGPILECGNYQLAADNSHIKIKYVCGFHVHELSWNKLRKKLSEGGLITADHPELTTCPLYNFTFCVTFYLTNQYPKCPPSLPVCFCNRTVVLRESPTKPPSDQSRLFEFTCANCDIEGVKPKCSWILRAKEVAFPRPKHKIHRIVDAEEYTDTKPSPLAANNSSNNNNPKYISKDHQQGLLCALTLNPQPSYMNNFQALKIADTSVNPEPSSSNSTSGSASPRYSSLVPTSVIVKRSTNPKSVAPGSHGNTCPLEKKVQEQELHISQMKTQLSQMNAKMESVESMVKLFKRALEDMQLDVYRHRHMFQEEQGLRRHTQSRLSSIELDVVQMLAEKEQLLAEIHDLTRGEEHNGETEKCRVCFNRPVEYVLLPCFHFAYCEMCSSRLTECAICRSVVEKRQKIFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K177</accession>
    <name>A0A367K177_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MPD1_1</name>
        <name evidence="10" type="ORF">CU097_008929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000415">
        <property type="protein sequence ID" value="RCH95963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K177"/>
    <dbReference type="STRING" id="86630.A0A367K177"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017017779" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="45810" checksum="B3BF428DD7627008" modified="2018-11-07" version="1">MKLPIIALLTVCSQIALSQALYTSKDDVNLLTPQTFGPAVMDTNQLVAVEFYAPWCGHCQRLAPEWKKVATNLKGLVSVNAVDCDAEANKPLCATYDIKGFPTIKIFPPELRKHKKTGKLSKVPTDYQGPRDAKSIVDYLLSNQPSNVLFVKWNEKDVKSKKSITLDNFLSTQNETLPKALLFTDKPTTTPLYKALSVEFKDRMLVGEVKQSEKNIVSEFNIQSFPTLVVISPEHGTVQFEGKLKRDTLKSFLEKYALESKASGDDSKGSADSSQPKKTAKVEAITTNDSLKQHCLNTNQICVLVITDEQDKQETIDILNALKDKNDKFQYGWMHASQSADIVNTLQLPQDYPSLFILHPSKHAFRNYVGAFDENKIHQWLNRVSSGAVDAWAYRGDIKLTERQHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K198</accession>
    <name>A0A367K198_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_014527</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01000419">
        <property type="protein sequence ID" value="RCH95925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K198"/>
    <dbReference type="STRING" id="86630.A0A367K198"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="190"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH95925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="456" mass="51866" checksum="47F4CB556CCAC70E" modified="2018-11-07" version="1" fragment="single">RIDAVSEEIEKNMLLMGGTAIEDRLQIGVPETIAELAKSGIKLWVLTGDKTETAINIGYACNLLTTDMELLVLKADNRTDTGILLDETLQRMRTEKVSEDIKYALVIDGVTLKYALEDATKDKVLAIGMNCASVICCRVSPKQKAQVVRLVKKGLKVMTLAIGDGANDVSMIQEANVGIGISGVEGRQAVMASDYAIAQFRFLRKLLIVHGRWSYLRTSEMIMGFFYKNIVWTFVLFWYQIFCQFNGSMIYEYVLITLYNLIFTSLPIIFLGIWDQDLNAETSLKYPQLYRMGLRNDKFKVWRFWLTTFDSIYQSAVCFFFPYMLLVGGPIDPNGYDANGLYEIGTIISSIAVCVANLFVVFSLYSYTWIQVLVVSLSILVYYAFVAVYAQFNTFIFGGHIRLFGTGFYWLTLILTVTACFIPRFAAKHYIHQYRPYDNDIIREIELVINKKRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1A6</accession>
    <name>A0A367K1A6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM domain and HD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SAMHD1_1</name>
        <name evidence="2" type="ORF">CU097_000476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000416">
        <property type="protein sequence ID" value="RCH95948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1A6"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000030">
        <property type="entry name" value="Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="75"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="365" mass="42487" checksum="86746FEFCC2F5519" modified="2018-11-07" version="1" fragment="single">MSINNIVNTFENANKFQEPKSFFHGHKVINDPIHGHILLDNYTVEFIDTLQFQRLRDLKQLGVLYYVFPGGSHNRFEHSIGVSHLAGTLVERFAREQPELEITKDEIKCVKLAGLCHDLGHGPFSHVFDNTFMPLARPGQKWTHEQGSERMLEYLIDDNHIDIEKDEVNFIKELIAGEAQSQSKYKERQFLFDIVANKKNSVDVDKFDYIERDSYNLGLRSSYDANRLLVYSRVINNEICYHHKEVYNLYEMFHTRYSLFKQIYTHRVGTAIELMIVDAFLAANNYLKIADMVDNPEDYLYLTDNIVHTIENEFLVPPELEGHLNQNVINAQNIVNYQSDNSGLVEDDVIVRFTKINYAMNDNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2E8</accession>
    <name>A0A367K2E8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trafficking protein particle complex 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRAPPC8_1</name>
        <name evidence="6" type="ORF">CU097_006706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000377">
        <property type="protein sequence ID" value="RCH96340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K2E8"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058538">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058540">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24544">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24546">
        <property type="entry name" value="Ig_TPPC8_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="4">
        <location>
            <begin position="738"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 second Ig-like" evidence="3">
        <location>
            <begin position="942"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 third Ig-like" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1464" mass="165958" checksum="7E183878B6F1CA47" modified="2018-11-07" version="1">MKEPFNLGSHLSARDIIAKTVAPVVAVTASEDAEELCRLNHIPSFTDLIKPFGDTLEKVTPRDWQGVPMSIDNFNVRFKSINKLEEPNHQAVMRLVQNQVKSRGEQYTGNIKKIRNRSDVAEDYLNVHLNDLTPWYTDFRDTLLSLRGIAEYETFDHPVATMIVISSLNTDPISTIMQLYNPNIPSFTLDKPYVDTNILRYYVVLHDPNLTTFEHSMAFFDKLKRTVGLHCYLLTINSKPRNPKDEDSIEDRSEDNIRHIWEEPLSESYRIESELQSYVTSNPDSSVSSLNTTPLSPSVGGGHTRSSSVSSSTSNLPATVVHGTSVQSFPIDSDNNSNQDSIARETIVINEEQQQASIQYGRCLTDENVNQIRSMVQEFVAQSLIPFMERNVQQWNEQVASARRGLTGRLFGASRRLFGTSSRSSSTQSLQSVAAQGPNVPYGSSSITVYPFAAPEAQMRKLADFAFMLRDYKFAYTIYDTVRRDYATEKAYKYHAGTQEMMGVCLLMMDQPLTSKTDVDRHFELAVQQYLNRCRSIFHATRTTIIYYELLKDRQMWKDIPTALVRMTGEDSDLRSGLFLEQAAHCFLRVNKPMVRKYGFHLVMAGHRYGKASQSITVDEYTKRLHAYRCYELAAAVLDNHSWSIAKNHVQFALGRQAFHLGRLEDSVAYFSNVLTDTKQTSQQQIAHIREFLFIYKQYAAQAGFDPLKRSFPNLGLPIIDNRTIQVTLSNAQSNLTHREEWAAMEIELLEESIANGFISSSKRAMAVQQQDDDRIVCAVEESAIIHVELYNPLQIAITLNSVILGCQYKASSKSQDSETVEHEEMLEGKQIEGSDLFEFEHFKLQKVSSVTLDPLEKKTISLAVVPGHEGSLLVTGLHYTLNDLVHTFKPFRKQGKRLNKTKEERMSVVYAPDRSLDILVTSPMPLLDLTLHHVPETILSGEVVQTVLEINNKGNKGLTALRLKTSHPSFICVGNPEDMDKNIYTADGSSTLSKMRLDNKLFDASVISIPLPGKKDSYQGAVKPGETTLVPLWIRGDRIGKHTFKLLFSYQSDEDNVMIAHRTLRYSAQMQVLPSLKINAFTRPSTTAINEYILGIEIENLQTVTQFELVQLNASSPMWDISPLSIDLSNSQDIESKTNIPPRQTTFAYYKIQRIASYESDISNIPEAWTSNALGALLNNQKKNDSKEKNLPPPIDLHLSKIAFRKNEIPADAPPLKTFSLNSRMHWRLGNLENQFPNISKEKYNQLFTLYNSGDVDLAIYWNIPNMKRQGHHYIIGVNLGIQQNPFQGNSTELMNQQNRTMFEATAKERAMLINSLTRNRVIKDESPVKVLVSAPDKKAHNFDNEGLLKVPVCLTLMNCSWNRTSRYTLELLSWSKTDQKNTNSGKSYLSIYPFHWNGSTVFTGSLQPEERKDIQVFAVFQLPGVYDINRWKLTVRTDDKEGSEVFVHQPTLPQLIATTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K423</accession>
    <name>A0A367K423_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000327">
        <property type="protein sequence ID" value="RCH96895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K423"/>
    <dbReference type="STRING" id="86630.A0A367K423"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="48016" checksum="EC7CBEF455CCFD6F" modified="2018-11-07" version="1">MCCSGNGPKWKREVVKDHKFDYIDIDEFYDPSCCGYLRYIIMFIIILKGFLVYVADLWTAVSLIVIGNTSVTDGAAIPPEVSRWIFLGAITISFILLFWDIRKARVIIESRDISYAFTSVIANRWYSAKDYRYFCLFQKINNSRKRIDSIAFFVFFTLKGWKRLLLAEAPRQVINIVSLYTMIPNWIQIKHGLKIEKDALGTTIMQKMMTGTMAFSVIVFAISFVLVCIAAIIYIPLLCHIQGNLKEYCCHKVDKRIAELLKKQARKRVEKNMKHGQKDNHQQHNRKKKEDIEMQSLAQPTLPQVNMDNLNSGYPHAAYYYPSPQQPHVRPVYHHQASNDHNLMMQSPYVRRNSLSSVNSDQAGLISHAQGQPTSPPFYQGHNGSNMSIHQHYHQPQPHYHSQQQPYIYSQNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4T7</accession>
    <name>A0A367K4T7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">37S ribosomal protein S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSM22</name>
        <name evidence="8" type="ORF">CU097_012608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000299">
        <property type="protein sequence ID" value="RCH97198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4T7"/>
    <dbReference type="STRING" id="86630.A0A367K4T7"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="440" mass="49970" checksum="1FA619FF450CDB66" modified="2018-11-07" version="1">MITRQLLRQSIKRNYSVKTERAIVLNQQQLQTFDLDLEGDFPVQEISVDSEPVVRGSEEASFGRKRIGCVELPRSLIQGVDQIIEHYPDKRLIRTDSLRLFDALRSTSGRQPQNEKEAVEPHKLTYGPRESVAYTASVMSGNYAAIYNVLKELKSRVSSFNPNSMLDFGTGPGTAIWAAKQLFDVEAYTAVDLSEDMLNVAEQLEKSVKMDKCQSIEFKRYLSYNPMAPKTDLVISAFTLGDITSEALQKSTVEQLWSQTGDILVLMDRGTPVGFQNIAKARQWILDEQDAHVIAPCSHDKPCPMLFSAESKPNQMWCHYSQRVQRPSFLMKTKHAKNNIEDIKYSYVILRKGKRPSPQSDMETQAYDWPRLIQPPLKKNKHVVLDTCSKEGEIQRMVIPKSQGKVPYRDARKAAWGDLFPHGSKNKVVTRLSKGVVEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5F9</accession>
    <name>A0A367K5F9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000280">
        <property type="protein sequence ID" value="RCH97407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5F9"/>
    <dbReference type="STRING" id="86630.A0A367K5F9"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="453" mass="51201" checksum="BBE24E6766E33BF2" modified="2018-11-07" version="1">MQFYPISKKIPTRLNYEFVKKYLEPLKGSVIYLTGGKTQTRDDTDVELDFRQESNFFYLSGVEKPGYGILILTDTDEIYLIPPTVPPIQQLWKGIPDSHDTLVRKYDVNHILTEEELSPFIHRIKPTTIYTLPSASNTFDSFQVDNFRLITAIHKARLIKSPWEISTLRYAAHISSHAHLSLMSHVAKQKGQVIYESELEARFRWICAKNGLPKQCYIPIIASGPRAAVLHYTDNDKAIPTGPHDLILVDAGGERQCYGSDITRTFPVLGKFSQEAKAVYNIVLQAQKRVLASLRPGVLWNDMSHLAIRVLCEGLLNIGVLKGNLDQLIQVGAYKAFYFHGLGHSVGLDCHDVGGHDIGILTRKGQSLELMNEPLQENMVITVEPGLYFNDVSIQMWTSLPEYAKYFDLSKINQYRPVGGVRIEDTVLITKEGHENFTIVPKEVDDIEAIMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6M6</accession>
    <name>A0A367K6M6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 2D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF2D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000273">
        <property type="protein sequence ID" value="RCH97491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6M6"/>
    <dbReference type="STRING" id="86630.A0A367K6M6"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="5">
        <location>
            <begin position="354"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="466"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62981" checksum="053665456C748760" modified="2018-11-07" version="1">MFKKPITNIKTFSPLRSSDRRHFQNEAIEAYPVLKDQYVMPNDLRSAKFIAQTSVHGIVYTSTDQPLWISFENMAPVPTVYTMWKHPDMLPILYTWTPVIQKLMEGADLMIPGIVPGPSGTLPELSQGDLVAITIRGYAYPLAVGTMALPSSEIKPRSGMKGKAVHVIHVYQDFLWAMGDKSEPPGLEQADDESEQEEVNVDEESNENSNDNLNIEQEPPKRDLSTEEIDGILKTSLYQALAHKLTSDHASQLPMSASSFYSAYIMPCRPIGAEAADIKKSSWKKLQKFLKAMEKTGLVKIKEQRGEVVITSVNWSHPCLQNVAKYKTIEQVDSSTPQTQTQVAHADHYPQADIQELFKPLGTALVKLFEEAEQDTEALYTYVELRTMLTNYIKQKELANPRNQKMVRLDAILCDALLSKAEYRTIDELPRDQLLTRLCSKMQPFHTIQLPEQKEPILRKGHPKPVEIVQEIRQGRKTVTKVTGVEAFGLDVDELVKEFTKLCASSVTSAPIHGVSPKNPLYQIMIQGPQIKNVTEAMLHKGVPKKFIEATDKTQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6Q3</accession>
    <name>A0A367K6Q3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi uridine diphosphate-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">YEA4_2</name>
        <name evidence="8" type="ORF">CU097_014018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000239">
        <property type="protein sequence ID" value="RCH97903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6Q3"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="40419" checksum="2332BD113E93F47E" modified="2018-11-07" version="1">MDNTSGFMGALLQIIASDMPMILSLIFGGCCSNVFALEVLVTDAPRSGQLITFGQFLFVAVEGLRHQLTWGTYGPRLKKTVVPLTHWLFLVTLFFIVSLLNNIALGYNISVPLHIIFRSGGLIVNMILGTLILGKRYSVGQITGVIFVTAGVIWATLDNASSSAESKTGNTTEFITGIALLVIAMVLSAGMGLFQEVTYKKYGKQWREGLFYTHFLALPFFLIFSKDLLGQVQEYNKSPLMPLSVILEEVPVLGSIATYTPDIIKTALHTIEIRKLWAYLILNMVTQYACIAGVNRMTSVATSLTLNLVLNLRKFTSLIISIIYFDNHFGFGAQMGTAMVVLGTLIYTRAGLKSSQKASNANVSASAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K786</accession>
    <name>A0A367K786_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000224">
        <property type="protein sequence ID" value="RCH98093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K786"/>
    <dbReference type="STRING" id="86630.A0A367K786"/>
    <dbReference type="OrthoDB" id="2290099at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016619913" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36128" checksum="347C4A23F0CD5064" modified="2018-11-07" version="1">MRLQLSSKLLLIFLQALLLLLCTVDCQSLPLEISNTSKEPSKTPASTTPPVIVPTVAPSSTTTTTTTTVAPPPPPPSSSAPTTTTLSTLAPSSSASSSIVLPPSTTTTVASSSARPSSTTTTLSSTSSSSSTTTSTKSATSSAPSASNSLPSQPQDTTPIIVGSVVGGVVGLALIGGIIACISRRGGCTKRRDRKKKPEFEDYGLGDFPPHQNIAPAATVTAATKPLSPTIPRLNDQGNYYNEDYNNYGYQQGDYGMQNPQHGGYYYPQMHQQEYYDDNGYYYDTSSGMGSTAVYSPQQPMHQGYNAQGYAPNNMVPQGVHQQDIYKPDDTKVPVHTGGGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8J8</accession>
    <name>A0A367K8J8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000188">
        <property type="protein sequence ID" value="RCH98553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8J8"/>
    <dbReference type="STRING" id="86630.A0A367K8J8"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017008509" description="Plastocyanin-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="250"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="373" mass="42757" checksum="5710682BE5A370FB" modified="2018-11-07" version="1">MTMYNTILLLLLPMLGLVCLAKPVNFTSTVRQFYIAAEEETWDYTPLHWNNYLNESLETSARFLLHTDTQIGSLYQKVFYRQYTDDTFTVPIPHDTSLGILGPILRAEAGDKICITFLNRARYTHSLFPHTTIPKSPRHRLPGQFVATGERYNYEWNIPADYSFPPNQSSVVWAYSSKSDPVKDVNAGLFGLVVIYKKGMLEWPSPGAMFQRPRGIDREIFTLMSITDESESRYFKESAALAGFSWDHVKKLQKTDSMFKHSTQMFHINGYLFNNNKPFTLEWGTTVRWYVVSFGVSSEDPHTAHWHGASVLYHGHRVDVVDLTPISFEVADMVPDNEGTWLFHCHVASHLNMGMTSVYNVEKVIITGDEGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8S8</accession>
    <name>A0A367K8S8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000182">
        <property type="protein sequence ID" value="RCH98633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8S8"/>
    <dbReference type="OrthoDB" id="5279943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="423" mass="48893" checksum="02BF342AE2A37DE4" modified="2018-11-07" version="1">MYVNNPHSELPTVKESQDALTESFARKLSISSLSSPSVDIHGQAVPSDILVALLDRPVEMVQLVSRNRQFYDAIQHYITETQGEYAWQRFQEILYKPREKLPDRAWLTCISHYLAHNSIFLSKFKEIVGYTEDTPDTISPPFYYKMSTSSSTASSNTSRRRSRRLSARSFDLDWPEEDSIIEEEAPEVPEGMFTDEEQFYQQTTPVGQQQPRRRRSSYHAFQSEPHPTFVESKIDEVEEAEVESGNESDHLSELLDNDEEEDDDYNSEANSQRISHDSSRQPTFKDRTRNNMGLVRVRDYPDVQTSLPNVYPAFFRKAKQILSLAPSSRRFSANVRRNSILEGGMPESPVIDLDEPRVQTCSDNEEDEENDHLTQLICTTRRQQPDDYLWLNNVMEVLGDWPELVDGLKDIIDDALIDHRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8T0</accession>
    <name>A0A367K8T0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000185">
        <property type="protein sequence ID" value="RCH98588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8T0"/>
    <dbReference type="OrthoDB" id="2205867at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016594771" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="13964" checksum="89A7CAD6647D3D78" modified="2018-11-07" version="1">MLMKIQSVFAIWAFLLASYVYCSDITFDYEYKKASGLFYYVDYQFYTSKGYSGSFNTKPYSIASDTGEWCSRDGILCVQDKNVGSTSGEIILSYANQKKTYNKSQFHKSGSLNQIFDRWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA74</accession>
    <name>A0A367KA74_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar transporter chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VTC4_1</name>
        <name evidence="8" type="ORF">CU097_001889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000143">
        <property type="protein sequence ID" value="RCH99143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA74"/>
    <dbReference type="STRING" id="86630.A0A367KA74"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="511" mass="59522" checksum="828D6FA3FE5BF462" modified="2018-11-07" version="1">MFLDTFCSNIYPPWSIEYIAYEVIHEGLYHYADKWKDKDEQDFLVVLKMEIRKVDFFIRRKERELESRIAYCERSQPYVDIHKEWIDILADLRELAKFIRVNYGGIEQLIQEHDKLLSLKCPLLVEARCLDTQRLDALYSKLMPLSKNDAKKQVRYYLLKPEYIEEIKAILIFHYPQCSTDKRTVTSIFADDDHFSHYTSLLERDEDATVVHGEEITDELRPKLWIDYQCQLSYHSTELSVSLCTDVMYSIPWCQKVSCPLALLEIKSNTDLSWLLPGDLLQPVPRFSIFIDGIARLYSEQLILLPAWLSNHQVPAFALWTPPLSGKEIDSSEGKVTLSMASTLTWNTSSSFKDAYYQGRNNQSVGYLLIQNEEEEGEEEEKPKKKKKKQSTLEPKIFFANERTFIDWLKFSMLILTAALTLLNFGDYVSMIAGSTFFGIAAVIALYAFGRYRYRAYQIHNTPHMRYDDLFGPFGLCCLFVAAMVLNFVLRWEHPSTPGTFLGTNNQTRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAN6</accession>
    <name>A0A367KAN6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000134">
        <property type="protein sequence ID" value="RCH99275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAN6"/>
    <dbReference type="STRING" id="86630.A0A367KAN6"/>
    <dbReference type="OrthoDB" id="2328895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041646">
        <property type="entry name" value="VC0807_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="39486" checksum="D5A77942A9752110" modified="2018-11-07" version="1">MRWPFGAKEKEQDTSHNTSRDSRTFLLQKQTSTSTAKVKEEEEEIVEYKYAPKQQDEEQPMDLGTLQDIFSFSFMRGRPILNFIMAILWSVGLPVLLYNVLKPYTGQVLAMIIASAPPFAIVIIRMIKDRTFDPLGCVAGISFLISGILSIAQPNEKVSAICESIVPFILGTACIISVIPIKIGSFELKPLVYQVANQIMPRAEVDENLKKQDIRRLTNQSGQKKLDYLYTHMAKFRQDMRYMTFTWGFLLILSSIVKIIIVFTSSSLTKAQIYGYILFGLTTFFMMIFTWFYTKIIKGHVLSQVAFWKEKKEQEEMDKKVETAYNAEWGVNTMSNAYGQVIGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCP0</accession>
    <name>A0A367KCP0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000085">
        <property type="protein sequence ID" value="RCI00013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCP0"/>
    <dbReference type="OrthoDB" id="2204877at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="21665" checksum="C81A8E110AA275E5" modified="2018-11-07" version="1">MLLIALPARPGTDLASKLLLQDSKMKHMIIAEVVGKGINSDAYYVGSCDRHDGRKTDVLYLPHCTPTNDLPPVIVEIQQKVNYPFIARAIRYCLDVFEETHIVPILVVFNVSDQVKTMQDFCDAISLQFGKIIKSAKDNIQCSTKRAIKYAEAGMQFSNKMRCLHDDDKSDSDVTPIESAIDENQGDDLAFAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFM9</accession>
    <name>A0A367KFM9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatoproteinsis-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPATA20_1</name>
        <name evidence="3" type="ORF">CU097_013845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000028">
        <property type="protein sequence ID" value="RCI01034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFM9"/>
    <dbReference type="STRING" id="86630.A0A367KFM9"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="425"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="690" mass="77607" checksum="D5A9FF373F80D8A4" modified="2018-11-07" version="1">MVDWYPWGNEAFELAKKENKPIFLSVGYSTCHWCHVMEHESFEDEKVAEIMNKYYVNIKVDREENPGVDRLYMTFVQLTTGHGGWPMSIFLTPELTPFFGGSYFPPQDRYGSPGFKTLLTRIARMWAANPNEIRSSGKNIIGQLQDYAATLPATQDDINFMEILEDTYGHFENSFDAIDGGFGKAPKFPTPVQLKFLMDYYHLMQHSSSESASKAIDMVTFTLKKIASGGIHDHVGSGFHRYSTDKKWHVPHFEKMLYDQAQLLSLYSFAYLITKESIFADVANDIILYVSRDLRHPDGGFYSAEDADSYPNEGATKKLEGAFCVWESAELENLLGPEVARVFSVHYGVKKNGNVPPSQDPHKELTNKNVLMETGSLADTAKAVGKTEEDVRDIIKLANTKLWEHRSQARPKPHRDEKILVTWNGMMISGLIHAYQAIKNENALSLAISAAEFIYKNLYNASSHTLIRSFCEGASDIGGVIDDYSNLIQSLLDLYEATLDEKWIEWAAHLQEKQNELFFDDANGGFFNVTTNDTSILIRMKDDQDGAEPSANAVALKNLVRLSFFLGNDEYMKKAQATVQAFQVPLTKYPYALPAFVSSFILVAHGSKEIVLAGKLDEKLQEFIQIANDIYLPNRILIYAKPDGFIARKNAVVGEIASKGTQEPTAYICKDFSCGLPINSPEELKTSIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG14</accession>
    <name>A0A367KG14_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000024">
        <property type="protein sequence ID" value="RCI01117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG14"/>
    <dbReference type="STRING" id="86630.A0A367KG14"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="22289" checksum="EAED8DC06329301A" modified="2018-11-07" version="1">MSGLSLSFDQAEHIDVCCNTTLPLRTLWIENVESLSPTFLNQIVRDVAELGLSKCSKETIKSISVILARYRQRSKLEQIDIYDCYMSDQMVRQMVMSTPMLKRFNYCRSGFLSDSSVFAIVEHCQLIESLIMTLPRHIVQANTVTFAALEVLAQLPRLKIFVCRGQVRIATKQNEEWMYKHCPSLIHCDLSFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGF6</accession>
    <name>A0A367KGF6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MTF1_2</name>
        <name evidence="6" type="ORF">CU097_015627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000016">
        <property type="protein sequence ID" value="RCI01304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGF6"/>
    <dbReference type="STRING" id="86630.A0A367KGF6"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="31347" checksum="76246337BE646ABC" modified="2018-11-07" version="1">MSRSKLAFNFKNAFPTCAEWANAFRFKTLKTLPRATLSSSETALECAKALNIQNPENRIALELYPGLGCWTRALKDIGFKRVISLEPQNVYYQWLQEEVFGPSEEKVSIFKMDGYEWETYGELKRPEHLGNLVNTDWSQVHPNLFFTGMLPRGRRGEQLLSQFVCCVHNKMAMHSLGRIPMAFWVPDLLYPKLTSVAGERARCKMSIVAEAVGEVKTIYETKPGDAYPDSTSYYLVSIVPWEKSRINADWDVFEYVLRHLFVQPKTKLTTAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGH1</accession>
    <name>A0A367KGH1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000015">
        <property type="protein sequence ID" value="RCI01323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGH1"/>
    <dbReference type="STRING" id="86630.A0A367KGH1"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="158"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="609"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="951" mass="108915" checksum="6CCD30F9911CDD36" modified="2018-11-07" version="1">MNNVITGSVNEAFSCFCDCISQLNEQDKAKLNLDSYFHDTTTISNEYTNNNAFVKGSTTAFPEPLASIIHNPLSIPYKLGFLLNANRVWLTANKTLYIWNFLETDNIFRYDCHDNIERVEICEKQKELYVCTRNSLFVHSFSIDTDNRLKILSKADARTSGVVMSNILNTDTGRTFMQGDDGHLYELNIDRDSNGLAVGIKKLSCITEQSYFRYLSLFVKSVPEVPIKKIALNNEEKILYILLKDSTIQAVDIQGNNFVYGHKFKATMVEDIQLVPTSESRIIDLIAIDGKGNRYYLSNKASGIGTVHERLAPPMLGSLLFNQFTNEALQHSFYGSGVFAAIVSKSSNNYLLLTRTALTKTAQTQPVFNEDFYAERLNDTLMIMESELNTPGRYIENIVEASGKPQRQLVALNKNGVTFYKEQRLIEQFSALLAKGNPSAIIEFTEKYGVDETLALCLLTSIISPAHNREATSFLYEYPSVDNGLLLYISRLLKDIRTVDILAEDVPLDAFNFVADQLEKLHSFLRQARINISNDLLTYTIRCKEGVHFVQFIYKVCLQNEAARKKLVDYAPLTFEKLVSTEKGAFAAKNVVGLESLRRAEVELNKKPELEQSLTHFKKIIELISLDQLKELCNKYCALRGNIESMKLVLAKYQLVNSEQKTQIYELIYDTLRSTFDEPEERLRVILQESLDLLDEEAYHEIIYQWLIDNKQERALVTLTTPHLVQFFTTKLPESVGYHYLFEYYTYRNEYYDAIVALKRLSTVIRNVDLDKRVHYLERACDLMGKSADISNGEKQELLALYKEATIQTKIRNVLQQRHASDSTSLVQSLNDVLKPAKELYYNIALPQNLYEEALYLMNFMELYDWKYAQLAWERIVKENKDSHALRNKLITMGKDLYPSIASCPVFMLVHILDAHCQAYPEEFKDEFVISTLTEVGVPQEIISEARTAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGY5</accession>
    <name>A0A367KGY5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPS1</name>
        <name evidence="9" type="ORF">CU097_015943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000008">
        <property type="protein sequence ID" value="RCI01484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGY5"/>
    <dbReference type="STRING" id="86630.A0A367KGY5"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="231"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="508" mass="57438" checksum="BE611E33D3EE4C9A" modified="2018-11-07" version="1">MLLDNSADGDSLHKPESDILKLLQEFSEANEEDCLPTKSYNSSTDETAGHDKYRSLKRTSIQDVHSAAIDNNILSDSTIRPDTHPYSSRIIRRKVNNEPTPSRSSSYISYSPIPSTPPSQHHPSSPSIHDYVYPTPKDTRNLTSSSINDIGNVGTETGTLERRVGNLHITEDVIKHPTYDFNQSATMVQPHESPVYNRNAAVMSTPTIPAETQIPPSYRQSDKIIVNGNEYTMFKEIGKGGTSKVYLVSSHVSGEIYALKWIEIKKRDDFQNTVNEIELLKSLKEEENIIDLVDYSATPSTIFMIMEYGEIDLATLIQLQAKKEWDILFIKYYWKQMLYAVNAIHRRFIVHSDLKPANFVLAKGQLKLIDFGIAKKHGDDTTSIHREIQVGTINYMSPEALLDLNEDNDGGSLMKLGTSSDIWSLACILYQMVYGKTPFYHLTIAQKVANIPNPRYKINFSKEILYGPRNTTVQIPDELILLLSRCLNRSPKLRPTISELINHPFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK94</accession>
    <name>A0A367IK94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005521">
        <property type="protein sequence ID" value="RCH77951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK94"/>
    <dbReference type="OrthoDB" id="2288352at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="165" mass="18630" checksum="E4472D0E05A10239" modified="2018-11-07" version="1" fragment="single">FNISPDTVGYHILHRLVNKEVKQLNQSPMQREIQQSLNSFNINTFVAFAQRENMIRVNGSEVLPLQTIGSIKLPSRVTDLNNDAVLYECIFHFYSSRYGPAQVCSLYRQIQPGQVFVDDKIIKFKSIEILGQKYKAATSTSSRGSYICAFMPGNDGNPVLRPGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILL8</accession>
    <name>A0A367ILL8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005070">
        <property type="protein sequence ID" value="RCH78558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILL8"/>
    <dbReference type="OrthoDB" id="2283943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="120" mass="13471" checksum="9A2B4EF5B3DBA3E8" modified="2018-11-07" version="1" fragment="single">KAAKILSTTSHVELTEAECKILNQDWLEYPQLRYCFSQLLAGCIMMQDEVSILVNTIKPYARDSLIDAHFERKSTGSPSSFPTTSGRYGFLTVCPFLANDDQKLVISTRTSNFLVTSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMQ0</accession>
    <name>A0A367IMQ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004800">
        <property type="protein sequence ID" value="RCH78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMQ0"/>
    <dbReference type="STRING" id="86630.A0A367IMQ0"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="16862" checksum="0D7AAF80CE149CB4" modified="2018-11-07" version="1">MVLLISKRLSFSITIKRYVSSKPWSYEQANAWIESFNKQKIPKEHTTVTFSRSSGPGGQNVNKVNTKVDLRLSLSKATWIPEYARDALRSLPHVKKSKDDEVIITSDKTRSQSKNVQDCYDKLVTTIKQAVAVPKEPDEATLRRVKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP24</accession>
    <name>A0A367IP24_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004503">
        <property type="protein sequence ID" value="RCH79437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP24"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH79437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="258" mass="30179" checksum="9DBFD051B4B25A5D" modified="2018-11-07" version="1">MSSLLSFQLRQQQQQQQQQHQEDQSGIPSPPNSFCGEEQPNTIPKIVVERRDSLQTVFNDMCIREYSASLPENYTIEHTAHRRASHAASTATAAATGGLTIRNNRRQSDAFIKRKNRGLSESYNNGQYRCNECGKSYKHPNCLQKHKWEHSEEWELTKKFPLTKHQQVQMLEAAAILINMDRRAKGLNEQQQQQQVDKEEEEEEIEIFRVDDEEVNQHMVKIEDEEDDESIVIDDEEEEEEEEEKERSQSPEIFMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRD9</accession>
    <name>A0A367IRD9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004048">
        <property type="protein sequence ID" value="RCH80189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRD9"/>
    <dbReference type="STRING" id="86630.A0A367IRD9"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="141" mass="15513" checksum="6800A9AE14759624" modified="2018-11-07" version="1" fragment="single">MSNSIAQQFIKNPHFVVVGASPDRQKFGNRILRWYQANGLDVTPIHPKESMIEGLNALNSIHQVTVPQQTSISIVTPPKVTLQVLQDAKQLGFKYIWIQPGAEDNAVKGYVAQNSDLKVILGGPCLLVDGPSLLKTREGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITJ5</accession>
    <name>A0A367ITJ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrator complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">INTS2_2</name>
        <name evidence="1" type="ORF">CU097_002345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003651">
        <property type="protein sequence ID" value="RCH80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITJ5"/>
    <dbReference type="STRING" id="86630.A0A367ITJ5"/>
    <dbReference type="OrthoDB" id="3363059at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="307" mass="35546" checksum="47C7BF8B0D73BC97" modified="2018-11-07" version="1">MKTPSLDSFYQLLKARVFYNTDYQSWLLDYMKNATLPIHSKIGSIIHEFVTCTFIVDKVQRIPENIIIEEFRDCNIITPTQVLLLFYVLTHNDFFIGCRTEPKLIALVANTSVEQTEYSTELLDQIPVKYILNHIETYQDGKAYKTIFSDILALSANLYPELFDVTSFLMQEGKEVDMMWNTEIKRRKTKQLEPEELVSILAQHESKQTDVIDALSRLEYAPISLVEEYAKCMISTLLPPCLDETLDTRVANCFVSAWESFNHIIPHSLWTMTIKSLTGENHSLSDLIQDIRTAFKCDERKVFDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUC6</accession>
    <name>A0A367IUC6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_004741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003506">
        <property type="protein sequence ID" value="RCH81278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUC6"/>
    <dbReference type="STRING" id="86630.A0A367IUC6"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016638260" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH81278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="296" mass="34230" checksum="2F043E9632E966A1" modified="2018-11-07" version="1">MARIKKRSLISLLTVLFIVLATLVPKVKAWTETDFEIFDLVDALEKAEGKDTNFYNWLGVSPSATQGEISKAYRKLSLKWHPDKNKNDPKAKERFARLGVIVSILRDPTKRERYNFFYKNGVPRWRGTGYLYSRFRPGLGTVIILLCLIASVMQYIAGQVNYRQEVRRIIRFVEDARAQMVANAPKGRAPSLGKSFIEVGQRVMRCEVKGDHYLIVYPNENSQQPIHLNVEWVKRPTIEDVFIISLPRRLFYKLLGKKDTTEQDEKETKEEIEESVPKKKAAPVRKRGAPKVNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUS1</accession>
    <name>A0A367IUS1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003441">
        <property type="protein sequence ID" value="RCH81428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUS1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="134" mass="15911" checksum="A51AC0A9427BAB2E" modified="2018-11-07" version="1">MDGPLTPSRSYSWTPLPHHPLPQSHRRRTTSDIGHVRHHMFVYNTVNRRTRSESTGSTQQTRTPWTPFEDELLRRGYNQGLSWAMISSTYLPHRSRGCCWGRFKTLQSKNLVDPNHMRYFKRPWKSIEFGQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVU0</accession>
    <name>A0A367IVU0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003305">
        <property type="protein sequence ID" value="RCH81736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVU0"/>
    <dbReference type="STRING" id="86630.A0A367IVU0"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042869">
        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="375"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="730"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="101796" checksum="E096AFCBF39F6590" modified="2018-11-07" version="1" fragment="single">MTSESTADMATITCSACQLPLEGNFARALDGAFHWNCFLCIDCNEPVAEKFFPIELEGGIQKPLCERDYFRRLSLTCDNCGEALRGSYITAVGKKFHLEHFYCSVCSTVFGPDDSYYEHEDNVYCHYHYSINFAIKCIGCETAILKQFVEINRNNVDEHWHPECYMIHKFWNVKLAQSVGEEDQKLNIGNKMTSEELKEAQNVMEEKVYRIWTVLSAFEESAAGCISDMLLHVSEGSYAEGVKMADYFVTHVEVLFSAIDDLAIQYLKQTKQELQYDRESSMLCKKVSNFFSLLSHTQENGLRKIGITQDLLSLVTGLAHYLKVLIRIGLTGALRLERKNDCKSSAISRFLSQLMELANKKRQYLHEADYTVSSDLCQFCRKQCEDACFRYKTYIWHDKCFACSLCCTPQRSDYKETYISQKDLSIICSKCITHIDGYVQGVQYVSKLRQSSFLLRFALRRLYSLLNVPDPMIAYYGQSYEHTSTQYQQQQQIQSIQPQQLQQQQRLLIQQQQQQQQQQQQHHHQAAIHTPPLPPLPKYVNGDDLPNEEIHLNDIKRMKSTHMNRKITNSHRIGKRSTLMETPIPNAAAVSNNIEESSRPQSQGTEASNKRTSFNELGSFSESSHQSRHRYTKSVPEAKSFYFAELGALQHFMLKHIAVLYLEEILHDHFTLEELADLIDDKKNSTLWGKFVTSLKAGGNKKVPKPKEGTFGVAIDVLVEKNGIESNLGVGPTRIIKIPSFIDESISSMKQMDMSVEGIFRKNGNIRRLKELSDEIDRNPNNVNLANESPIQVAALIKKFLRELPDPLLTFKLHKLFITAQKLENEADRKRVTHLACCILPKANRDTMEVLFVFMKWVSQFAQLENNTGSKMDIVNLATVIAPNILYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW95</accession>
    <name>A0A367IW95_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">INP52_1</name>
        <name evidence="6" type="ORF">CU097_002185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01003208">
        <property type="protein sequence ID" value="RCH81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW95"/>
    <dbReference type="STRING" id="86630.A0A367IW95"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="141"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="813" mass="92434" checksum="0A2E90610B006ACF" modified="2018-11-07" version="1" fragment="single">MQTHLLLREYPRALALRPTVLEEAPSGVLVLQAHEEQQNKAIAKLYSPNEFEDSEWRILNSRPVFGCLGLITVQSDCFVAIVTDCVSVGRIRAGEEVYKIQSVSFYSLSSGRYDDFMDFSYNNGYDSDDFDNNVQHPCAQLQKLLSVGNFYFTPDFDLTKTVQARTSVASSGVYSFDQHFLWNQFMISGLLEFRSKLDRKKQMDLDRGGFLIFAIRGYVGVETIRIDHDRYELSVISKLSCQRAGTRFNSRGIDDNGHVANFVETETIFYSDRICYSYTQIRGSVPVFWEQQGMQLVQHKIQISRGPGATLPAVKRHFDELINRYKHVCNVNLLSQKEGTASGESLLSTAFNTAIHQLKGYEDKVRMINFDLHAECRGGNYDNVAYLMNDLGSIIDEYGYFLMDTEDNQIVCKQKGVFRTNCMDCLDRTNLVQNEISKRLLLNYLYSRFRNSRSSQIDHLMARHSHLWAENGDGLSKIYAGTGALKSSFTRTGKVTFMNVLSDATRSVNRFYINNFQDKARQEVIDLLLGKLANQIMIAIHDPLSDSVTQQLTKRVKEYSKSRKITILCGSYNLNGRAFKGELLDPWLLQHFKSGNTEEPDIYAIGFQEIVELSPQQVMATDAETRKVWEDQIERTLNSRPGGKSKYTLLRSNQLVGAALVIFAKSSIVDEIRNVESSIKKTGIMGMAGNKGAVAIRMDYGDTSFCFVAAHFASGQANVEDRNNDFYTINEGLRFLRGRTIDSHDNIVWVSDLNYRVSLSNLEASCHAREYVHQGNIEALLHHDQLIREMNQGNVFPGYKEGLITFLPTYKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWK4</accession>
    <name>A0A367IWK4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003159">
        <property type="protein sequence ID" value="RCH82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWK4"/>
    <dbReference type="STRING" id="86630.A0A367IWK4"/>
    <dbReference type="OrthoDB" id="2248860at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9748" checksum="9E1D8384465A650C" modified="2018-11-07" version="1" fragment="single">LDLKKKLEIATSVNADEQRIKTMGGRLLNDHDILFQDGLKEPAIFNLTVRMVGGLQRRVIESHLQETLVWNNRLRDKRQILIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX30</accession>
    <name>A0A367IX30_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_001585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003093">
        <property type="protein sequence ID" value="RCH82238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX30"/>
    <dbReference type="STRING" id="86630.A0A367IX30"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH82238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="307" mass="35429" checksum="1753706609A91C8E" modified="2018-11-07" version="1" fragment="single">MTEAPQRRSSISSLSFYSDSSISESSSEHSGEQPLDRQRLENIIMYRVTHHLDPTQLPGILAAIEREEGEEDEVEIDLSQLAVNQLEHILSYVDTCIHQNQMAKDVSHNDNKATSHRHRYRHTRTTPTSSLLPKPELRPSKSRGGSNQVKNISKRKRALHRRRLLENMLASSSEANSSDDGEPNIIVFDELLEDKKSVNHTIVHESKNSLDVPERYPESTLEDSDEVIDIMLKRPGPPPKAYTKRAEQNRAAQKAFRERKQKYVKELEEKVMFMEQLKIELEHLREENIKIKAYATKLEQQLEEKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXZ5</accession>
    <name>A0A367IXZ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002988">
        <property type="protein sequence ID" value="RCH82516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXZ5"/>
    <dbReference type="STRING" id="86630.A0A367IXZ5"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="10997" checksum="9BE1FF74DE7ABDC1" modified="2018-11-07" version="1">MSAELAVVYAALILEDDNIEITADKLQTLVSAAGVEVEPIWFSLYAKALAGQDLKALLMNVGAPGAGPAVAGGAAAGAAGEAAPAEEEKKEEEKEESDDDMGFGTSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY56</accession>
    <name>A0A367IY56_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002952">
        <property type="protein sequence ID" value="RCH82620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY56"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8793" checksum="A6CA24C67182F9CC" modified="2018-11-07" version="1">MSQTQPPRTSSYQRLVEKLKRNPSERFDPADWPRPKNYSQVLDHAVKGGTRAFILGYGVRGGVNFCLYLIRVLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY86</accession>
    <name>A0A367IY86_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PMI1_1</name>
        <name evidence="18" type="ORF">CU097_004111</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="PJQL01002953">
        <property type="protein sequence ID" value="RCH82616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY86"/>
    <dbReference type="STRING" id="86630.A0A367IY86"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.441.10:FF:000001">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="164"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH82616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="416" mass="46450" checksum="1FC7A51E5407AFB8" modified="2018-11-07" version="1">MTSIYRLQCKPQSYDWGKLGDVSKVAAYAKASGVEVDNSKPYAELWMGTHPNAPSIVLNETQISLGQLIKDNVQLSTQAIYDHYNGDLPFLFKILSIRKALSIQAHPDKTLGARLFKEFPQNYKDPNHKPEMAIAVTPFEALCGFRPLEEIAHHMKVYPELTELIGQDLTHEFLEIIKSSDEQAKKAVLKKVFAAVMRGSQDTITQLLAKLIHRLKESDDKDTISKLLIRLDEQYPGGDVGVFSCLLLNYVSMEPGQAIFLGANEPHAYLSGDCVECMATSDNVVRAGLTPKFKDVDVLVEMLTYRYGSAESQKMTPIKFGEHSLLYDPPIEEFSVVWTNMESNQTEKHKPIDGPSILIVTRGNGKLTGNLLKTEQTYDLQEGYVYFVGANTPISAESGESGLEFYRAYSVPPTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZW2</accession>
    <name>A0A367IZW2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002737">
        <property type="protein sequence ID" value="RCH83216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZW2"/>
    <dbReference type="STRING" id="86630.A0A367IZW2"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="4">
        <location>
            <begin position="61"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="642"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="85362" checksum="07549F62AAD69A8B" modified="2018-11-07" version="1">MELDGPWFVDSKTKRTILFKGINLSGGTKIPVGLPSQENNGYWVDYDRRVNFVGRPFPLDEADEHLSRIASYGFNLLRFVITWEAIEHEGPGIYDQDYLNYLIQVLKKCEAYNLKVYIDPHQDCWSRHCGGSGHPGWTLVLAGLNPLHFPDTNAAIVHNLYSNPDEFPKMIWNTNYQKLAAATMFTLFFAGRTFAPKCIVNGVNVQDFLQDHFFRCMAEVVKRIKENQLDTIVIGYDCMNEPGQGYLSIHDITRFNKVDTDFRMGLMPTAFEGMLLGSGHPTVVDQWEFTWSGPKKTGRVMVDPKGKQAWMSSEELEEAYASFGWKRAESWPAGCIWATHDVWDIDTKKVTQPEYFATHPQTGLPTKFSDYWLDHFKNYMDTIRRIQPDSLIFVQPAVLEIPPKMSFPTERLVYAPHWYDGLTLVKKKWCNYNVDFINLQRGKYGTGPLRYLRALRVGEKAIRQCFVDQLKTMQQEGLENLGEYPCILGEIGIPYDMEMNQSKDESLFSHCFSYLLSFFQDSQGDYISHPKSNQNKAMDANLFALEKNLLNYTLWNYVPDNDAKWGDLWNGEDLSIWQLVEKDPDFLSNTESPQDSTSSITTMKTIVVENEDMTDIKKATMTEDSLSNHFRQNARDLVSLHRPHPQITAGIPMGITFVSPTFTTPASFEYTLQPNFECIGPTEIHVPIKNFPLPPETKVNVNFGRWEVSKVTDHDWILSWWIDEDIKEAEPKLRLEGISCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J139</accession>
    <name>A0A367J139_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002593">
        <property type="protein sequence ID" value="RCH83658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J139"/>
    <dbReference type="STRING" id="86630.A0A367J139"/>
    <dbReference type="OrthoDB" id="2217172at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11729" checksum="725C48BE92F36C2A" modified="2018-11-07" version="1">MAQLCQETAEEKRIIARKQLFPKHPTFLIELFDNNTLMVLEETFSDLEAFISGYYKHIREKYALSLKRVTKNTVERDTTKIIQLRFDIITQWEAAGINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J142</accession>
    <name>A0A367J142_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002625">
        <property type="protein sequence ID" value="RCH83549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J142"/>
    <dbReference type="OrthoDB" id="2340007at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="185" mass="21183" checksum="6502C8719747E39D" modified="2018-11-07" version="1">MKTIHSLINYTRITTLVLSILIVITSLFKYNNSSMPVSTMLEPIKQGRDMVHDIIQDRRLIATLVASQASIFCPLFLLLNHSVALNLSSAVIIEQLFQCLMPIGLVISWYFCITFDQHIKLVIDLKDNWLDIAPKYAIVGVLVIEIILIIIASFKYFYIIYKEGAIQLPYEEEKECIPVYITDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1D4</accession>
    <name>A0A367J1D4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA methyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRMT2A_2</name>
        <name evidence="6" type="ORF">CU097_000762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002565">
        <property type="protein sequence ID" value="RCH83753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1D4"/>
    <dbReference type="STRING" id="86630.A0A367J1D4"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="470" mass="53582" checksum="1FDCDC8D0ECDE47B" modified="2018-11-07" version="1" fragment="single">KLNGKEFKKRLLSTEYTKVSEKQFRDRFKVNKTIEQEDTRTPAQRLADQVTPLHKLSYEEQIAKKHKAGVRHLRDLRKKLNALPDLSEEARAQINWTTSDNPDDACQILDPIQSPITHGYRTKCEFTIGKNIQGERTVGFLLGQYRDGVTAVLEPYDCLHVSDKAKEIVRAMERYVRDSEYDVYDKVAKTGVWRSIMTKTQETGDIMILIQMKTDELSDDQLKQEKEKIRAYWTQLKPEINTTTLMLQTWNGVSNGITDKGQTEILMGDGYVYEHLLGCRFRISSSAFFQVNTPATELLYSKCAEWCNISQDKKTTLLDLCCGTGTIGITMAKTVDRVIGIEMIPEAIVDAKANAHMNNITNVQYYASKVEDKIDIVTNERNEQVVAVLDPPRAGVHPSVIRAVRESPQIKKVIYISCDAKQAMQNFIGLCRPTSNRAKGIPFRPVRAVSIDLFPHTEHCELMIEFIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J225</accession>
    <name>A0A367J225_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane proteolipid Pmp3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002490">
        <property type="protein sequence ID" value="RCH83997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J225"/>
    <dbReference type="STRING" id="86630.A0A367J225"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016778011" description="Plasma membrane proteolipid Pmp3" evidence="7">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10285" checksum="C3D4CE1B674AABDE" modified="2018-11-07" version="1">MGPYSNRDIFLFILAFLFPPAAVAVKTGCSVELLINVCLCILGAVPGIVHGFYIVHKYNDNVEDLETGGLEYQRVPTEQPDRLGYGSTAPPPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3V9</accession>
    <name>A0A367J3V9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fanconi anemia group D2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FANCD2</name>
        <name evidence="7" type="ORF">CU097_000256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002320">
        <property type="protein sequence ID" value="RCH84605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3V9"/>
    <dbReference type="STRING" id="86630.A0A367J3V9"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1233" mass="139687" checksum="FF3C3435E72FCC1D" modified="2018-11-07" version="1" fragment="single">DMQTYTEDPAALRKCLLPSTTANHVSRTSRTTNSESLFKTLLAVDSIQSELITYLLERLPEFYDELENDNSSSCTARLILNQLRWLDYIAQPEALTEKLIEPIVVYLKELMNENSELTVPILDALSNLTLHSESLDDVKETVLDRLESAELDDIAVILKFMLQTVTPNTVDMVILGIRQKLDFRALGKIQQDNSQRRTKQSLSQRSNVKDTPEALILESIKLGLQFHKFVCEAWFRTIMALETARAHKIIDVLILFILYSMPSMKKKAESAIKKKIIQGLITAPLLEETIMCHASGLASYWNVILSLSEGLLRSCQQNGTISPCASTLYISSFKVCDSYYRQEIIGSLVTHIGSGVEAEMSIALNVLLHLAKSDVSSVTVYSVFIKGILDYLDNLSLYQIRILFDIFSLIALTSNNTADGSGNLWADIQIVIRKQLSNPREKYKNIGIIASLSAIRILGSRERCSDIQSQQGGSSSQSVKLSATRHPLLRQSINILDSLMRNCNGYPACISLCYDELAHIFSEGELDERLEEWIKVNLTSDFTEYYLSTVEDTLQYINDIKKVSTNRLLPSLQMNADEEDGVDIVVKLYELIARKDIKSKKNLVVPMCSTFNLMQICEKQLNNGSLEGINALSGCSILLFESDDLDELSPEELFDACDILFYTINWIREVLNSFVEAKDEDLSQTLIVRLRHILELESRLNNCLKYAPNYVPFEFHNTLSISPKNESSRPSQIIDNTQVNESQQTESPSRTNIKKETRPSNINFGSISELRSYMRAFNLSVFEIFKHNTNQVRMTYAETSYILEDLNNKLDIKIVPASVSAFGRKKVTSENKYPSSNSLLLARIDEHQFMKKISPSLPYILQTLEDLYADIQQQGIDSGRIGGVEEIAKAISLIFNVIFKMLSWSYIQSSDNKIILETIIQALAERISGESKQNGSSPEAQLRQAFQYLCHYGANMPQSTTAVLLFKILLRIMELSDNPLSLKQGALSVVNQIVSTSWFDWRDIKKEIEFLIEKTIELDDDPLQVLHNLVNDVLPRYEDQGPLEDHPLLKSDTVVQYYQAIISQIVNSFELFKSTDQEPEIVLVQNGRIVKIFERITHYVKVKEHRLLIGVLLKTGKLFIDQFTKHSIPYFTEIFKAHKTSILAIFKDLQASTRVLQIICSHVKVLKDVSLSAYVPPLKRSLENIIYQVKMLVTRNGIPAPAFFMGALKHRDITGAEISSQVRAIHVLILDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J445</accession>
    <name>A0A367J445_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002282">
        <property type="protein sequence ID" value="RCH84734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J445"/>
    <dbReference type="OrthoDB" id="2258247at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="181" mass="20338" checksum="349AA7019F91B7DA" modified="2018-11-07" version="1">MFEFQEDLSFTTLIPDPHLYCHCTSIVTSSNTLGNVVSSTTLGSILIDIIPVINRLLFGHEISATCGGDGNVWSVEDIIRCDSNKSFVEITTSHIFREEAIKAGVSLSSFEKRFFGYPFLSPDSNILQIIFFNLPRLYGRFKEGIQEICHDMFINLSRYGIIVDCGTVRSLIGIIWVEDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5I6</accession>
    <name>A0A367J5I6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002160">
        <property type="protein sequence ID" value="RCH85193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5I6"/>
    <dbReference type="STRING" id="86630.A0A367J5I6"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58167" checksum="C3F1B0598B27D5DA" modified="2018-11-07" version="1">MDTYIMNKENQKALAVSGIVLALTAYLIKRVSDKKNKTYKEIPYPTGSTNWPIFGHMLSLGSIPAMQFKKWHDETGPIYKVRMGKQTWVMISDPYLAHEIFVKNGANTSSRPYHRFNCDIYARNSRGIVFTQYTPEWKNNRKMAASLLAPASVDKFSGLIEYEIDCLMDRLKQVAKEGVAINPFRELQLTALNIVLTVLVGTRYDHIDNPLVSELNELIDQGMVYAGAAGDLRSLVPSLAWIGTLFGLDKKMTHFIKQRCDPFYGKLIQGALEQDADSLAKSLNKMKEEGLISGDDMHVLITDLIAAGADTVSVTLYWTLATLAFQPNIQAKIIQELDAWKAEHVPGAIPSFHQDREAFPYTICVQKEMIRYRPATSYGIPHVASEDIVAGGYLIPKDSVLISSMGAMHMNESIYKNAKSFDPDRFKNNTSRMSASANSKVDDRDIFAFGWGRRMCLGIHLAELELFSFYVRFFSEFTIEPELDAQGNPVPINIEGFVDEGVVNKPLPYKVRFVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5T8</accession>
    <name>A0A367J5T8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_005671</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="PJQL01002156">
        <property type="protein sequence ID" value="RCH85209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5T8"/>
    <dbReference type="STRING" id="86630.A0A367J5T8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="15">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="244"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="16">
        <location>
            <begin position="535"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH85209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="695" mass="76987" checksum="CAD7BFA12DBF556C" modified="2018-11-07" version="1">MSASTIDPFRHRVAPPFELNRHQEETLAAILDTFVATLPKEQADDLVEKLKNTHTEEEVRRFCQISSTSIDSISSTIRLINNTVLPAKRIELMKLLSILSTRPGTFALTGYFSEFKNLPFADREKIILGWKNSYVPSLRIIYKSFHALACLPAYKSHIQAFTDAMHYDTKNDTVYEDLPERLPMMSFDEVKDNMYFDVIIVGSGAGGGVVASQLAQAGKSVLVIEKGRYYHENDFIHTEQDGHENLYEHGGFAPSLDGSISIASGSVFGGGTTVNWCASLKLQHFVREEWAKQGLTYFTSPKFTKDLDRVFERIGATTEGVTHNGSNQVLIDGCRALGYPISDIPQNTGGRPHECSSCYAGCRAGIKNGTMNTWLRDAYQHNARFLEKTKVNKVLIKHGKAVGVECLVNYDKKVRIRANQVVIAGGSLQSPGILIRSGLKNKNIGQNLRLHPCSIAAGFFDRKIRTFEGSIMTAVSGVAENLENDGYGCKLEVPCLPPGSYSATLPWRGAAEHKEFMMRYENCAPILILSRDKDSKGSVTYDKDDNPVVNFAVSNRDRRSLLEGILRSLDILVAAGAREVHTGQFGVDKFKFKEEEEARIDNPRYVAWKNSVSSYGLPRDGFNMFCAHQMGTNRMGVSPKTSVVKPTGETWEVKNLYVADASVLPTATGVNPMVTVEAVALHIADCINNNNQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8H2</accession>
    <name>A0A367J8H2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NDE1_2</name>
        <name evidence="13" type="ORF">CU097_008930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001917">
        <property type="protein sequence ID" value="RCH86210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8H2"/>
    <dbReference type="STRING" id="86630.A0A367J8H2"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="80"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="459"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH86210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="528" mass="59272" checksum="B9D4B9D788A9F48C" modified="2018-11-07" version="1">MQSIRNVPAARHSIKAVKQPLLLPVMKQFSTTSPTHLPQWALISSAVKYGFLAAASYGMYGAYAWRHPRVQAPMDPDKKTVVVLGSGWASTSFIKKLDTRYYNLVVVSPRNYFLFTPLLPSSTVGTVNMKSIIEPIRFITRHKKRAVQVFEAECTAVDPASKTITIEDHTPEKDHHPVKSLSYDYLVIGVGARNSTFGVPGVDKYGCFLKEAKDARKIHNKLMDCIENAALPNQSPEEVNRLLHMVVVGGGATGIEYAAELHDFLVDDLRTWYPDLADKIKISLIEALPNVLPQFSKQLIEYTEKNFQKQHITIHTKTQVKEVHPKELVVKKADDSVSTMPYGLLVWATGNTTAALVQKLKEQFPEEQTAKKGLAVDDWLKMKGCEDIYAFGDATHTQYAPTGQVASQQGKYLAHQFKQMFIRDALEAQLKKAQDEKEKEKIQKKLNHIKEIKPFQYTHHGSLCYVGSEKAIADLPLGPFGHLASGGAATFVFWRSAYLSNLFSFRNRTLVLLDWIKKSLLSRDISKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J924</accession>
    <name>A0A367J924_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L-tyrosine:2-oxoglutarate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_003741</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01001863">
        <property type="protein sequence ID" value="RCH86452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J924"/>
    <dbReference type="STRING" id="86630.A0A367J924"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000048">
        <property type="entry name" value="tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="16">
        <location>
            <begin position="39"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH86452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="409" mass="45220" checksum="6415DECB408D28E8" modified="2018-11-07" version="1">MSSERASWNIKASRTANQAHNPIRAIVDKLKVDPNATKPLISLSIGDPTIFGNFNVDPSINDAVIKQINSYRANGYPPADGTLDARTAVAKAHTHPNAPLTASDVILANGCSGALEMCVNVLCNEGTNILLPRPGFSLYGTLAATRFVEARYYNLIPEKNWEADLEHLESLIDEKTSAILVNNPSNPCGSVYSREHLEAILKVAEKHHVPIIADEIYCDLVFKGNTFYPMATLTSTVPILSVGGLAKKWLVPGWRVGWILIHDRQGVFREIHEGLHQLAQVILGPNSLIQSALPDILEKTPASFYESTIQQIQANVDLSMKIIGRIDGLKPVTPQGAMYMMVGIEIEKFKDIESDVDFSAKLLAEENVVCLPGECFKYPNFVRFVITPTIDKLEEAYKRIEAFCDKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9E1</accession>
    <name>A0A367J9E1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KRE2_3</name>
        <name evidence="5" type="ORF">CU097_005149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001844">
        <property type="protein sequence ID" value="RCH86547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9E1"/>
    <dbReference type="STRING" id="86630.A0A367J9E1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="377" mass="45331" checksum="FC59647ED0663AEC" modified="2018-11-07" version="1">MFIRRRKFIGCQILSIVTVLALMLYLRFPKRVIPYRSNSPSIKKTSVRAAFVILARNSDLTGVRHSMRQIEDRFNRKFNYPYVFLNDNDFTDEFKQKTSHLTKAQVYYGKIEPEQWSYPDFINQTKAAEGRKKLEEMEILYGGSESYRHMCRYQSGFFFRHPLLDSFEYYWRVEPEVDFYCDIDYDVFQMMKDNKFKYGWVMSLSEYIETVPTLWDTTQQFMEKYPEYIERGNDSLLPWVIGDDGSYNLCHFWSNFEIASLDFLRSKKYLDYFEHLDQQGGFFYERWGDAPVHSLAVAMMLKSSEVHFFNDIGYKHIPLTHCPIEPWHQRKCSCDEEENFDWTDWSCTSRYAQVHSGFIWNETTYRQMTDPYRLSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9M4</accession>
    <name>A0A367J9M4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001824">
        <property type="protein sequence ID" value="RCH86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9M4"/>
    <dbReference type="OrthoDB" id="10268383at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="94" mass="10836" checksum="FAB2FFA4C2EAF793" modified="2018-11-07" version="1">MPKKIVSDFGDKKFYLICQDGRAQEWRQNKEGTDLIDVVLDGRIYKASKEDPEGSPVATGDPDLRQAYGDQDYKRIMYDILENGKETNHRFPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAR7</accession>
    <name>A0A367JAR7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001766">
        <property type="protein sequence ID" value="RCH86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAR7"/>
    <dbReference type="STRING" id="86630.A0A367JAR7"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="315" mass="36479" checksum="B2B390E6D79B9A50" modified="2018-11-07" version="1">MFELRSIKFAFGLAVLFICLFSLYTLQQRTMTTPDTANTKWKLKNYAQPPPDVLAAIDRNTITERMQGQKKPLNILLIAVVNTGMMNYTLNWIESLKRTGQDDKYLVFAIDQGVVDIMTERGYEQHVTLIPADWFHRPLDSGFARWKSNSYLPITHAKTLVVERLLYFDMTVWFTDVDIVFLSPHIRATMLAQMGGRDMVFSQEIDQRVINSGFYMMRPTPASKRLMGLVVQGQDDTQVLTQQKVMNRVLRSAFTRDFMKCPYRFLDMLLFPNGCDYFRKNLPNKLGIQPLMLHANCLIGDKKKDALAKEGMWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB44</accession>
    <name>A0A367JB44_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70 chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HSP70_1</name>
        <name evidence="4" type="ORF">CU097_000186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001735">
        <property type="protein sequence ID" value="RCH87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB44"/>
    <dbReference type="STRING" id="86630.A0A367JB44"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="512" mass="54969" checksum="0F586C52B9D43165" modified="2018-11-07" version="1" fragment="single">MYRLSKLTTKTFPTVRHHVGVLSQLRPYSNKVSGPVIGIDLGTTNSCVAVMEGKNPKVIENAEGARTTPSVVAFTKEGELLVGQTAKRQAVVNPENTIYATKRLIGRQFKDPAVQADIPSVSYKIVPHTNGDAWVEMTGGKRYSPSQIGAFVLGKMKETAESYLGKKVKHAVITVPAYFNDSQRQATKDAGKIAGLDVMRVINEPTAAALAYGLDKAGDETIAVYDLGGGTFDISILEIQNGVFEVKSTNGDTALGGEDFDSHLVRYVVDEFKKETGGMDLSSDRMAIQRIREACEKAKIELSSTVQTDINLPYITADATGPKHINMKLTRSKYEGLVGDLIKKTISPCEKALKDAGVSAREVGDVILVGGMTRMPKVVETVKSIFGKEPSKSVNPDEAVALGAAIQGGVLAGSVSDILLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQVFSTAADGQTQVQIRVFQGERELCRDNKLLGDFNLTGIPPAPKGVPQIEVEFDIDADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC99</accession>
    <name>A0A367JC99_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001630">
        <property type="protein sequence ID" value="RCH87564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC99"/>
    <dbReference type="OrthoDB" id="2292715at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="128" mass="14714" checksum="0B137F926318FFAF" modified="2018-11-07" version="1">MSFHLETPSLLFPSLFTKQQQSTIVSRSVSLPNYSHIYYYDKEDESELSNVSARPYQNQLALPSRHQFQSLRGLSQRKDQYEDTSKPSIAIRVSLPMPSIAAASVAKSRRIKLIKAQMEPLIRPRRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDL8</accession>
    <name>A0A367JDL8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ERG4_2</name>
        <name evidence="19" type="ORF">CU097_009838</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01001544">
        <property type="protein sequence ID" value="RCH88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDL8"/>
    <dbReference type="STRING" id="86630.A0A367JDL8"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="472" mass="53725" checksum="B6E7B07B210FB34B" modified="2018-11-07" version="1">MTNLKSGINSNGVPLFKNKITELDKKLDNEVVYEFGGPLGTLGMMLGFPCLMYYFWVCLEYYQGSLITPSSFTKEGIIEFVANIVSKVKMGAAPTPIAIKIYMGFVLYSFLCAYLLPGPVVEGLPLPSLKGGKLKYVCNGLAFWYLTMALSAVLHVTGIFRLTAIIENFGSIMTVAIIWGFTMSTLVFLSAVITGKQHRMSGNVIYDFFMGAPLNPRIGHVDLKMWAETRVPWPVLFYISVSCALKQYEATGSVTAPVAFMVLAHWLYCNSCQKGEECIPTSWDIFYEKDGFMLIFWNMAGVPFTYCYAPIYLLKSELTKGVRIQHSLPVTIALFITLLFAYYFFDTGNAQKNRFRMEQNGSFMTRKAFPQLPWSHIKNPTYIKTEHGNLLLTSGWWGIVRKPHYTADLVQSLSWGLITGFGSYLPYFYFTFFVIVLTHRASRDMERCAKKYGKDWERYCERVPYILVPYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEJ9</accession>
    <name>A0A367JEJ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_005435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001481">
        <property type="protein sequence ID" value="RCH88356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEJ9"/>
    <dbReference type="STRING" id="86630.A0A367JEJ9"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="251" mass="26417" checksum="D9920AB41FADDD8B" modified="2018-11-07" version="1">MAATKKSTSTTTSTKKSDHPTYEAMVKAAILALKERKGSSRPAIKKYILANFKVSPGAHFDTQVAAAIKRGHAKGIFELPKGLSGTVKLNKTEKKEETKKPAKKEATKKEVTKKETSPKKESSPKKEAPKKTAAKKKAAPATTTTTTTTTKRTAAAAAKKAEEAKKTETKKTAAKKAAAPKKAAATKKAAPKKASPSKKKSTTEKANVKAPKKKTPAPAKKAAAAKKAAATKKATPTKKATTASKKKETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEW0</accession>
    <name>A0A367JEW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_002342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47780"/>
            <dbReference type="Rhea" id="RHEA-COMP:11911"/>
            <dbReference type="Rhea" id="RHEA-COMP:11912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001462">
        <property type="protein sequence ID" value="RCH88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEW0"/>
    <dbReference type="STRING" id="86630.A0A367JEW0"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000164">
        <property type="entry name" value="Methyltransferase NSUN5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="232"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="478" mass="54292" checksum="207F0414BA95A2BA" modified="2018-11-07" version="1">MNFYQHAGRILDKLARHEGTIKGLVIGDPKVQDKKKMYALVCETLKYKQVLNELIDSTKICEIEKKLKRSLALVLIHDLLFTKRGITVRNEVPLKQCVMRHQARLKAELIKIKIKRGVTTNEDLVSQKVKDAVLIPRYARVNEHKTTVEKAIKAFEKEGYVLIKCPENLCELKQKEFCIDQHLPDMLIFHQRTDFHDHPLYKSGHIILQDKASCFPAHVCHPPQGAHVIDACAAPGNKTSHLSALMKNTGKIWAFDLDSRRLGLLKRLTGKAGYITPIHGSFLEADPNDPQYSQVEYLLLDPSCSGSGIISRLDHLVDGEDENEGSNDKNGSTQEERLKNLSEFQISVIEHALKFPNAKRVVYSTCSVHAEENEHVVKTVLKNNPEFELASRDTVLPTWHRRGMPEEMDGDEDLADRVVRTIPAEDLTNGFFVSCFIRKTSEGLKRTIDKVETVQEAKPNKKKKRNNNKKKKTALTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG37</accession>
    <name>A0A367JG37_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001389">
        <property type="protein sequence ID" value="RCH88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG37"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802884" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16168" checksum="C59D078FE7743F56" modified="2018-11-07" version="1">MYKSIALVAILAIFLQQVLAQATCTDPVNFNACMDIQQKKLGTCGPVDYGCQCEARRLIVECYNLCPQREAEKSIDSASMQGICVAVPTSSSASLPAATNSVSAPVASNATPSAAASSSSSAKPSTSATTTTSSASHTQPLAVFMIICMAIGFYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH04</accession>
    <name>A0A367JH04_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_003616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001327">
        <property type="protein sequence ID" value="RCH89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH04"/>
    <dbReference type="STRING" id="86630.A0A367JH04"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="52"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="566" mass="62269" checksum="17580CB393B4BEE4" modified="2018-11-07" version="1">MITEKIQDDRSSTFSNKEETKIEHLNETDDRISASSLESQQPKLKRSLKARHLAMISIGGVIGQGLFLSSGANLNAAGPAGALIAYGIIGFIVYWVTYSLGEMATYIPVSGSFTIFCRRFVDTSFGATIGYNYWACWAIIVASELTAIPLIMSFWTDKVPSWAWSGIWLIIIFVLNMFGARSYAEAEYIFSVIKILAVLIFIIIGCITSGGLIGNTSPHEVYGFKYWKDPGAFSNGVLGVVNAFVLASFSMQGTEIVGITAGECENPVKQVPRAIKNVFWRILIFYLGSGMCIDNNRLPMLFILAIILVFVMGMLIRYDDPRNLSESSSVTVSPFTIVFELAGLNSVAHIMNAVILITVLSCANSGMYVSSRMLCALANEGIAHKKLAHISSRGVPIYSLICTALVCLVTFATSFIPGKALFIVLTSLSGVAGFVTWGGICFAHYRFRKALKVQNRSIYELPIRTPFHPFGDIFGMIACVVISLMAGYSYFVPPSATGLIGNYAGLILCAIGYIVTKLWTRSKMIPLDKIDLDTGKADIMFTEEDRDEIIGSWYNRAWKRFVNIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH56</accession>
    <name>A0A367JH56_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AVT3_7</name>
        <name evidence="9" type="ORF">CU097_008423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001328">
        <property type="protein sequence ID" value="RCH89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH56"/>
    <dbReference type="STRING" id="86630.A0A367JH56"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="215"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="607" mass="67497" checksum="532748D1D70556D9" modified="2018-11-07" version="1">MESSQIPESTIASIAQQHLVHETDAQGSDEEAAINTSPTSNTDISIPYHLPGAAITHDIYNHVNTLVQQNQQLQRSQSTNELRSKHRPNEGPEPTFEYLDKPGGFRRFHVQQQHWLAQQQQQQEQQEHNPAFHELFRPDSVCSNRQEYTVGLLQPAEQRPTRHFLEYLALTSVINQFAGEDLSDSESEEGEISETTRLLLLHRPKKKKKTVEAKADVRKTIFLLFKAFIGSGILFLPKAFCNGGLVFSIVLMWLMGGISLYCFLLLLECKVQFPGSYGDIGGRLYGPWMRSIVLISIAVSQMGFMCGGTIFIVQNVIEAVRVISHDTVHLSPRLVFILLMILLTPLVLIRNIARLSPTALISDALIIAGLVVLLCYDGAEIVTSPTHTGPNIHWLFNPVGYTTFIGTAVYSYEGIGLIIPIRDSMEKPEKFPFVLAFVMFLVACTLCTVGALGYIAFGQQVETVALLNLPPGILSSSVQLGYAVAVLLSNALTLFPTIRIIEHALFGDLTGKHNLFIKWEKNMLRVTVVIVGTLIAWVGASDLDKFVSLIGSVCCCPLSLIFPPLFHLGLPGTTVWKRWIDRLLILFGTSVMVFTFYSTSKQWATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHG0</accession>
    <name>A0A367JHG0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001300">
        <property type="protein sequence ID" value="RCH89373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHG0"/>
    <dbReference type="STRING" id="86630.A0A367JHG0"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="211" mass="23945" checksum="D711A89A6169DB1C" modified="2018-11-07" version="1">MVIAASMAPYIHIPIPGPILHLDHLTLVCIYIGCILVDYFICCCTSIPYHKYKLWLATFHILMPILVAPLAKGWTTSYIAVPWLIASAGVYVAEKYKRTLTLTAWFKTAFIECMATNPQGDQIRRRGVQRLLRILLGLAICRYMITPLLPEVPQILFQYPWYSIPGVYYTFLMGFKGYLLMNASTVSLSVIQTTCGIDLLEPFDKPFLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHP3</accession>
    <name>A0A367JHP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_003829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001286">
        <property type="protein sequence ID" value="RCH89447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHP3"/>
    <dbReference type="STRING" id="86630.A0A367JHP3"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH89447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="182" mass="20750" checksum="6CF3A6A155D67032" modified="2018-11-07" version="1">MALSQRFFSDVFRDMQRAFSLLEHPNFFDAARRSLVASNLNNNNNWNSLLRYPATDMVETPESFELQAELPGYDKKDIQIELADSRTLVLSGTMNRQHEASSNQEQQQQQQQVEGSSETAVSKETNTPQWWVNERVTGSFQRSFSFPVPIKADGIKANYENGVLKVTVPKSSEESKKLIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ37</accession>
    <name>A0A367JJ37_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001200">
        <property type="protein sequence ID" value="RCH89950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ37"/>
    <dbReference type="OrthoDB" id="4368495at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="74" mass="8316" checksum="2DB609469F481BE8" modified="2018-11-07" version="1">MAQWIRRLTTNQEIPGSTPGSLTSLFFTPRSRSFKTTNRMPAFNLCVVMNTSNQGNGKVRPDQTGFGQDSYLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK15</accession>
    <name>A0A367JK15_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translin-associated protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001148">
        <property type="protein sequence ID" value="RCH90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK15"/>
    <dbReference type="STRING" id="86630.A0A367JK15"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000001">
        <property type="entry name" value="Translin-associated factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28788" checksum="3B23C3442DDC1F14" modified="2018-11-07" version="1">MSQDFFKECRDILDEHHDRRERIIKVSRDITASSKKMIFALHRAINQVGGDRTKAKFKEAETKLKEIMALFKKLSVDIQGLNYFRYARSFSGAFEEFVEAVAFHHYLLYEKIITKQEIDTYFEDEENGKWLSVRDEDYILGLGDLTGELMRYAIQIVSSGKYEQAMTICKTLREIDRDFELIASAYLPVLHKKMGALRASIKKVEQACYTFQIRGSEYPKEMYMTIIKNHQENYEQQQQQQQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKN1</accession>
    <name>A0A367JKN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PSF1_1</name>
        <name evidence="9" type="ORF">CU097_003793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001111">
        <property type="protein sequence ID" value="RCH90502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKN1"/>
    <dbReference type="STRING" id="86630.A0A367JKN1"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="206" mass="23531" checksum="163868D86D9E3E97" modified="2018-11-07" version="1">MSTLGEAAYKLAKEAKRTSDLLVTPYNDDLVQTLCRENRLFHNKAKTTVENMKASMDPNITRDPSKISQVMLYHLATKRNKRVLFAYHRQRINKLKEIYWNVGLQSEHQKEIRASLGPGEHQFLEGYVELVNAYKQHFLDIDLGGNGGVGLDPPKDLFIQVRVIRDAGEITTEYGILNLVKGNQLHVRRTDVESLIKAGYLQHVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM21</accession>
    <name>A0A367JM21_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001043">
        <property type="protein sequence ID" value="RCH90945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM21"/>
    <dbReference type="STRING" id="86630.A0A367JM21"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="506"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="741" mass="83649" checksum="857460DF49378B14" modified="2018-11-07" version="1">MLQISDQTDTLTPPPLVAHWFHAIDSPIVDPIALRKAKRLGVAEQTRSPPKNWVPFSKRDNVALEKACNSDIQTVPVNEDHLFEVNIKKREINPVYWEGPIFEVRRATWFVQIDGTWIPCEEKMAKQIEEGYLKHKPYKRPTIQPTEKETEGSANSTDTLDDTTPRKDSIEVYIEEKEYLLGPYLGQYVVYKDSAHAWLLYDTTGAKIAKNLLTKLTNNQILGGRRLIRGYREVMVENKKQNEEKEEADKKEQTIRSENEPKEDNLHTPPPDDPKKREELDKENMIKQEAEDYENEESEGDLRAIDHLVFVIHGIGQKMSERLGQNFVHDVNLLRKTMKSTWPIALSGAKPLKRSNGIQVLPILWRNSIRLGAEAELGIERESDMGLSPEGFDDGCPTIDEITLDGVPNIRTLVSDVFLDIPLYFTNKYHDQMIHSVTKEINRVYKLFIERNPSFLKNKGQVSILGHSLGSLLAFDILSVQPFPANQKPDTDTIAILTEKKLAVTLDFPVKNFFAVGSPLGMIMVLRGHKMVSRKALAANTVPHNPISPSNGASAAVSFVYPAVDHVYNIFHRSDPVAYRLEPLVARQYGAKLKPASIPYIKGGLKSMLDAGFVVGNDLATKAGAMLESFKSGITSSLFMRGLGFNKQEKDVSELKQHSQSDPEIKASRTIATCEAKLKMLNPTGRIDFCLQEGLLENAYISALSVHMSYWQDIDVAGFLIREIYKEQRQMNLVHSKTAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM72</accession>
    <name>A0A367JM72_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PFK1_2</name>
        <name evidence="17" type="ORF">CU097_010848</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01001028">
        <property type="protein sequence ID" value="RCH91050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM72"/>
    <dbReference type="STRING" id="86630.A0A367JM72"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="168"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="555"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="555"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="357"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="448"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="683"/>
            <end position="687"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="728"/>
            <end position="730"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="820"/>
            <end position="823"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="902"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH91050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="937" mass="101294" checksum="E838C0B0FAE8F1A3" modified="2018-11-07" version="1">MAKGLSHLVFIASTEESYHHTIDFYKAFGFKVISVSNGEKQNEIWLKLDSNEHAMTSDIVIKLILSVGSVPRPRPDNESDWSLNSSAIALSVMDVSAVKSQLDSLGCEYQDRSIKSFSGTFQLIEVYCLDPLNNTVIFSNKPSFPSLLESAPAGLIDDINEKMDKIKKIGVLTSGGDAPGMNACVRAVVRYGISKGCEVFAVYEGYQGLVDGGIKKMDWKSVRGYLSVGGTSIGTARCMTFKTREGRLQAAENLIKNGIDALIVCGGDGSLTGADVFRSEWSGLNQELLEAGRISEEEAETFKYLTIVGLVGSIDNDMSSTDITIGAVTSLHRICESVDSIGTTALSHSRAFVIEVMGRHCGWLALAAGIATGADFVFIPERPPPEDNWEETLCAVAHRHRKLGKRKTVVIVAEGALDKHLNPIKADHIKDILSDRLGLDTRVTTLGHTQRGGSPAAFDRILATIQSVAAVDAVLSATPETPSPIIGMSNNEVTTGDLMKAVELTHEVAQAIGEKNFARAMELRDPQFIEELEAYTATTILDDDSMLLPPHRRLRIGIIHVGAPAGGMNAATRTAVRYAINRGHKAFGINNGFPGLARGSVEELTWIAVDGWTSRGGSELGTNRAVPGEAVDIGMIAYQLQKYNIQSLLIIGGFEAFSSVIKLEQARHQYPSLCIPIACIPATVSNNVPGTDFSLGSDTALNAIVDSCDAIIQSARSSRRRVFVVEVQGGKSGYLAVEAGLASGASTIYIPEEGVNLSRLQSDVRHLMAMYMDDAADKSEGRIILRNESVSKTYTTQVISDILKEEGHALFDSRTAVLGHIQQGVNPSPLDRIRATRLAKCSLDFFEKHTAAALDRAHSLNGPAPIDLCRVEHSAAIIGLSGSKVTYRCVKELVPLTDMKNRKPLESWWLPHRPLVDLLSGRGLFTPQAQATLNHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN09</accession>
    <name>A0A367JN09_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADE3_1</name>
        <name evidence="21" type="ORF">CU097_001463</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000986">
        <property type="protein sequence ID" value="RCH91316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN09"/>
    <dbReference type="STRING" id="86630.A0A367JN09"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="19">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="20">
        <location>
            <begin position="130"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH91316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="924" mass="99835" checksum="A5238C042352399A" modified="2018-11-07" version="1" fragment="single">NVRDKVKEEVAQMKSKYPQYAPCLAVIQVGEREDSTVYVGMKQKAAQAAGIEFIYKKIPEDVTQLELIKQVKQLNDDDKVHGILVQMPLPAHIDESAVLEAIDPKKDVDGFHAFNIGNMTKKAATPLFLPCTPKGIIHLLKTTGTTIAGKKAVVLGRSDIVGTPVSILLTSENATVTLCHSKTEHIETYVKEADILVVAIGKPEYVKGAWIKPGAVVIDVGTNPIKDPSKKSGMRLVGDVEYKEASRVAGAITPVPGGVGPMTVAMLMENTHLSAKRFLEESISPKRTVIPLPLHLKTPVPSDIDIAMSQTPKHIVDLSKELGLTASEVEPYGATKAKISLDVLKRLSHRKDGRYIVVTGITPTPLGEGKSTTTIGLVQALGAHLNKMAFACVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAVTAANNLLAAAIDARMFHENTQSDKALFNRLCPAKKGVRKFAPVMLKRLEKLGINKTEPSELTEEEISRFVRLDINPDTITWQRVMDTNDRFLRKITVGQNPTEKGMERQTGFDIAVASEVMAVLALATDLKDMRERLGRMVVASSKAGEPITADDLGIGGALTVLMKDAIKPTLMQTLEGTPVLVHAGPFANIAHGNSSILADRIALKLAGSDENLEPGYVVTEAGFGADIGMEKFFDIKCRVSGLVPDAVVLVATVRALKMHGGGPEVVAGRPLPDVYTEENLDYLRKGCDNLIKHIQNAKKFGVPVVVAINKFTTDTDAEMELVRELSLKAGADDAVACDHWSRGGAGAVDLGKAVIRTCEESKKDFKFLYDLSLPIDKKIEIICRDLYGADGVEYSDLAKEKIETYTRQGFSGLPICMAKTQYSFSHDPALKGAPTGFVIPIRDIRASVGAGFLYPLVGSMQTLPGLPTRPCFFDVDLDEDGRVVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPL0</accession>
    <name>A0A367JPL0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000944">
        <property type="protein sequence ID" value="RCH91621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPL0"/>
    <dbReference type="STRING" id="86630.A0A367JPL0"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="311" mass="36116" checksum="699EFA1950A03142" modified="2018-11-07" version="1">MAILEEINEGTANLFKLNRDINELSQEEMALIKSFIAEQVARNSADYEKLTSQMTEELNKCDFEDMAIQPQVGFVCKTNIIKSTSNIKPGTSIYINICFNCNLPGPEYTGDEQELKKALNGDPTSTYRLPLYISEPRHEDGHIIMDAVIQTRAYSRALKDLEYKLYVLEIAIENAEQKLNASLSREFKIPAYMSHKGGPIPSMVVKQPKELTFNKLRTALEQRKEEWKPRESIQKKNDELIIVIPMPHQNINEWKVQISQDELLLYAERQTHTIRLKYSIDVNNPENRVDFYKRDKQLVCKCKLLNRRQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQT5</accession>
    <name>A0A367JQT5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000856">
        <property type="protein sequence ID" value="RCH92245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQT5"/>
    <dbReference type="OrthoDB" id="2117820at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="296" mass="34199" checksum="AB8ED7C8401F5D1F" modified="2018-11-07" version="1">MTLLTSVYKRAIGHTSGLFWRSISSSPKTIKDFPWLLSKDKPRITNYPYETTDPVMGMIPISLQRMATNWVATRILQLNTGMNYFPDQFLVGASLATRKALQLLSDQLQHPEESREEIEYIFGPALLHRYTESAPSDANISIQLPQIYDVNVDDIWVTMGNPAAYSDENDKYDIFRWATLQFGVNKGKNEDQESFQEYKQRIRESIIEGIQVSVDVVVDADIVYQATHKETDEILLHDEGRRDLRIRFATPYFQPANKMVRSRDSETGEPVISWSWRIVDIDQLIEKEAMDSHEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR67</accession>
    <name>A0A367JR67_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000834">
        <property type="protein sequence ID" value="RCH92396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR67"/>
    <dbReference type="STRING" id="86630.A0A367JR67"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="316" mass="36471" checksum="22F92BED42C606E7" modified="2018-11-07" version="1">MGYIVELDNKSDRSHCRGPITICPSPDRRIEKGELRLGVEVERFQGITWRHWTCCTSEVINNMKNTLSSPEAMGGWDELREDDKERIRRAWEEGDIPDNEKPEPAHSKRPRPDENDVSEEETEDEVDNENASQDENTDQPEYTDDEAHHDENYHEENTKHQEPSPTHPSRKRKIVDQPVSEEEKDRKIRKMRSEAGRKGGRASRGKKKPGAVRSVGRGSRSKTGSEIRNDLPKNMTSQDFEERRLADEDHINEMIDEQDYEEDVDPRYVLERLVKSIGTELQLFSPSELSPPKNAGKKRNAKEEGDVKMKKARATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRV1</accession>
    <name>A0A367JRV1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000792">
        <property type="protein sequence ID" value="RCH92692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRV1"/>
    <dbReference type="STRING" id="86630.A0A367JRV1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="46595" checksum="6164B6410BFA03C4" modified="2018-11-07" version="1">MSRSWLPRILTCFRSYTTLPEREQLSHVSNRLLNHLHHNRLQQAHVMLLKQTIPLPVHFYNFVLKGYAKNFQRPNKLEKSLEILQLMKERGVEPSSQSYIQLIMGLAQKGTRLTKEQADLMQTWFDEFVRIESGSTNIKKPFAKFKKLMRCIYYRGHPNLKGMFYHFLDTFREHKLDDSETWNLAIVGCIRWGNIEDAEDILKRAREEKVANSTSFQVIIKAHLNQGNRRSASMIFRLLLKDDILADRETYETFIKYYLRQKNSIEMIKRLWQGVLMTTQPGDVIQPDTVVKLTQYYRERDALTEAEQVYLDMKMKQQKLTTAYIEQVSWLVAEFANRKQFNSTVSLYLDMIGNGYKPDREAVDRMLSALQDNNRFDLIQQITSVTASVLSDDNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSE4</accession>
    <name>A0A367JSE4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000774">
        <property type="protein sequence ID" value="RCH92826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSE4"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="112"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="310" mass="35329" checksum="A94957781C59C99C" modified="2018-11-07" version="1">MSLLTRGCSIFIGARVSYSTFRHLGVEKNAGALQDLLRRVMEIDAEITNTPLPQEYNPNTQICNAYNTADAYYMDKLRYELTMTDQREFRITSEINAKDALHIVDQEQGGDIFVFSNGSFACWGMQPSQETKFSSLYVTKSERKRESNAVIEEAKETIDYTVDEDEITDLKGDVAILNPLGIHLSKLAFSYGLGRVAKIKSMEISLDKSIQSLEHNCRVALSTGTSKSTDYNQWLSEFLFIRSRAYASANDGFLGTSSFKWENSELQDIVNKISARFDAQTRIDIFNRKIDYAMDLNNIWLKYLSKQIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSP4</accession>
    <name>A0A367JSP4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_007741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000762">
        <property type="protein sequence ID" value="RCH92926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSP4"/>
    <dbReference type="STRING" id="86630.A0A367JSP4"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="350" mass="39231" checksum="2EBCCB961AFFDA79" modified="2018-11-07" version="1">MVKAYLRYEPFAPFGVIASTQSNIVLEEVILWDLEKGTEIARSKESGNKSEMTSIAKSPNNKDYAGTDAEKAVCISTEGYLFSFSKGTLIKLWDLVYYYCCELLMGHHLWWCRTSVEGLQIDWHIMDLSLEELGEQTNNKDEKDATTAASLQKAINPYRNIPNSKRAREKGKDDSQVSEKITPEDDFASEYLIRTPDKVRSFDFSPATNVEKAEAYTIPIAEKKSEESNEPSKLYSLDVPGHRSDIRTLTLSSDDELLASTSNNLLKVWSLKTRTCIRTMECGFALCSALLPGNKYILVRTKTSELALYDIGSSTMIESIKAHDGAVYSLQVRSNKPGFVTGSTDKDVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTE6</accession>
    <name>A0A367JTE6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000730">
        <property type="protein sequence ID" value="RCH93186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTE6"/>
    <dbReference type="STRING" id="86630.A0A367JTE6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35452" checksum="0A4AE78BADC78914" modified="2018-11-07" version="1">MRDFWSKRNYSFEQIPDLTGKVAIVTGSSSGIGKVCATEMARKGCTVIVAARDEKRCQAAVEEIIEATGNKKVEYIRIDLMSLASVKKFADEFKSRYEQLNILMNNAGVMMCPFALSEDGIETQFATNHVAHHYLTMLLLPLLEASTPSRVVTVSSMGHMLLWKKFDLESISDPEQYSTLQHYAMSKACNILFTRELNKRLENKGVKNVYVNCNHPGIVRSDLFRHLYKPGSWKEWLNNFIFISTEDGALTQLYLATSPEVEEKDIRGKYCVPFGVVSSPWGAAAHNDRPLELWEYTEKLIKEKMPDYESPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTI1</accession>
    <name>A0A367JTI1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000716">
        <property type="protein sequence ID" value="RCH93282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTI1"/>
    <dbReference type="STRING" id="86630.A0A367JTI1"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="51345" checksum="0EFDA427FB9EB79F" modified="2018-11-07" version="1">MEHNSRSYSEEKTELSQDSILTVEQTSSLQPADEPPPRKFLWWIPLQHHVHPLQFFAFIFAVFLSLSCIVYIAGTQPQILMGILAVYTNTGDITGSLSLYAEIIAVVGVIFWSMASDTIGRRGVMSCSILLMGLAIVCYPHVKSVYPSLLILKLLFSIGSSGSTAMMVAMMMEVAYGKGGLVSGCIGIASGLGATFAALCLFMVPAYLSIAYPGGNHGITYSHAIIGGCSMVLAVVLFFAMPKDSYTRPPINHFKAYGSKLYRGILAAKEPRVALGYASSFFARADEIIISNFLSLWVQKYYIEKGMCSIGKTCLYSMASSSTLSGYSQLVALAATPFFSLASEYLPKEWAVFIAGVVGACGCIPFAFSIDPTTKLSLGFVILIACGQYGMIISGMAMVAGKHVDRKDNAAVSACYSFIGAIGIIILSKVGGVLFDKWMKGAPFLLLGIGHALVCIMSIIVYLQQAIIERTRKRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTI2</accession>
    <name>A0A367JTI2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Actin organization and endocytosis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PAN1_3</name>
        <name evidence="15" type="ORF">CU097_011882</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000729">
        <property type="protein sequence ID" value="RCH93195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTI2"/>
    <dbReference type="STRING" id="86630.A0A367JTI2"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="205"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="396"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH93195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="679" mass="75809" checksum="FECA7F910893BE32" modified="2018-11-07" version="1">MAGPSKGIRLSFLTQADQSKYEMVFSQASGGNDILTAAVAKEVLSKSNVGNENLAHIWDLSNVTNEPQLTFPEFAVAMYLTALKMTGVDIPPKLPDEVRQEIINAVFTIKNSNQNLALMQQQQPTGTLSNTIHAHPTGIPVNQTTTGFQLNPQMGPQIAMPTGMAGNNMDFTSRMMPQTGSYREPSQFQSLSSNIKIPWAVTAEEKKQYTKVFKAWDTENKGTLSGEKAKEIFSQSGLPQNVLMQIWNLADPNNQGKLNVDEFAVAMHLIYRKLNGYNVPETLPPELIPPSTRDLKESVSKLKQTILDDIAKKRYISNFSSSPSSLSPPTPQYKSRSTSPARGTIKKKDSEDDDNEVGYVSSARRMGPDRTRTRDNLMNKPATNTSYGYRGKTTRIFELRKEIEENKRQLQKLEEEAKPKVAAPYNDLSALDKKSIDSLKDRIRELQREISKSGNEHGRDAWGVYIEKTAELSGIAEEERLLVDEIEYMLDITLKGLLDQVDETEDDLMNKKIQAANQKATSNNSNSLTDVPLDIVGTGPNGEITEADRIRAKAKAMVAARMGKITGKSSNTTASNVKAEIEKIKQERDEFRLYVDSIKDSLGEVREAVKAIGLEMSMIGLDIRKQDQDQKRIEERARFEYGESVAKDLKEFISELNYDAALAKAPEVDPTFESRFPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTM6</accession>
    <name>A0A367JTM6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000749">
        <property type="protein sequence ID" value="RCH93041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTM6"/>
    <dbReference type="STRING" id="86630.A0A367JTM6"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="632" mass="72331" checksum="47EA797585266484" modified="2018-11-07" version="1">MDQNQPRKRVRTTRACVYCRKKKVRVFEIRCDGRHPTCSNCLQLQLNCEYAESKKRGPRKGYVQTLEERLTEMEKRLMTNNGVVMPSASLSPIQPSFSNRNNDMEYDLPSKEIVDHLVNIFFKHINAFLPFVHRSILKKSIQEGTISRPLLYSVLATSARFSDHPSIRTDPPYLACERFAKKALSLVDASTLQPTMSNIQFWGIMSFVEYGRASGSMSWVYGGLAVRFCQELGYHKEEIQSTPIVGEDGSVNAFEMAMRRRIYWSCLILDKMASAGTHRPQCIERSDCDARPSSFAENILLRDPELHTNIQGKPIQEDSLLSVSVYYMNCVEKFGEVNRYMNRISNNKPSSIVWPPIAEHRNLDNQLHAWQENLPEKFKFTQSNLEHHQTSASAQNLTTWLSSHALWCSSMMMLHRGSLAYFDMSHQVGEEMHRRIQASVETCHMCVDAAMGIFGAMKDLCHYNVLPYNGYSAYIFATALMTSAFSQTQEDREKSRRGLQILYELIEGLSPYWQMCEKLAKATKELLINHKRLYGDSLYNGYESHRIDMMPAMENSASLYSSQTYYITGNNNDFNPEIYNQHTSILSSALNSQKNNIDFNSIEFLFDTELFGQVVLDSGNANAHNLSNVPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUZ0</accession>
    <name>A0A367JUZ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_013307</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000655">
        <property type="protein sequence ID" value="RCH93794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUZ0"/>
    <dbReference type="STRING" id="86630.A0A367JUZ0"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000276">
        <property type="entry name" value="Acyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="15">
        <location>
            <begin position="5"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH93794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="224" mass="24203" checksum="A5D0278CDCD4CF00" modified="2018-11-07" version="1">MSLTSVVIGARAKHTATVFWLHGLGDSGAGWSFLAEELGKAFPHVKWILPNAPVAPISMNFGYLMPAWFDLHGLTKESLETEDEEGMLASLESVGKLIRNEVDSGIPANRIVVGGFSQGCALSLLTGLTSEYKFGGIVGCSGWLALSKRISQLASDANKNTPILMCHGDRDQVVKYEYGKESAETLQSLGYNVSFKTYPGLTHSANAQELADISEFLQKVIPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV63</accession>
    <name>A0A367JV63_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000654">
        <property type="protein sequence ID" value="RCH93798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV63"/>
    <dbReference type="STRING" id="86630.A0A367JV63"/>
    <dbReference type="OrthoDB" id="2274555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="109" mass="10878" checksum="181E4A79D0E1D678" modified="2018-11-07" version="1" fragment="single">MIDAGNGIDIIIPPNILSNAKGLAIFTVLKAGFLFSGRAGSGLVVARLPDGSWSAPSAIMTGGMGFGGQVGAELTDFIMVLNTTAAVKSFMDHGSITLGGNISVAAGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVH1</accession>
    <name>A0A367JVH1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_001136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000638">
        <property type="protein sequence ID" value="RCH93930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVH1"/>
    <dbReference type="STRING" id="86630.A0A367JVH1"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="54"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="244" mass="26662" checksum="1EB11A689382D696" modified="2018-11-07" version="1" fragment="single">MASSNYHLPTIAAVAGFALAASGYVLSTNSFESKKRRRRIKNKIRRERDGKYIYGLTNTGNFCFVNAVLQAFATLSSLRSYLAERVDEQGDESAPTVPQNEFILNSVACALYATIELLNSPIAKPQSITPIDFLNALQQKFGGTISRDQQDAHELFQIISSVLTAEEEIQYKENATSLLDAATVKSFTGDNDGNSNENFETSSVSSFGTSASMWSSFSVCTVGGSLRPRRRSPRNPFTGLAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWV5</accession>
    <name>A0A367JWV5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000584">
        <property type="protein sequence ID" value="RCH94385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWV5"/>
    <dbReference type="STRING" id="86630.A0A367JWV5"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="85"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="452" mass="52762" checksum="94F4064725A4C67F" modified="2018-11-07" version="1">MNYTNDYGNIPENATLSTRSNDYHPYQLFTDNTRSEFTPMIFHTAPMNETNNDMELIQHVHDYNLDIAPPLFPSSPCKNTQSQRGIAGFVSKLYQCLQAPESDQKYARWCKHQGRDMFIIECIPGNKIYIYDAIHIYLKPFAEFTETVLPRLFKHCKFPSFVRQLNIYGFQRDTDARKSKDSKDRESCRWYHPYFRPGRRDLFHLIRRKATRYTRRKRAKQDEDPETILNIEGDDEPAFEEDAQTVKSNNNNNRRSSSSASSVRLPEYYPPPSQLQLTYEPPVANTSSALMHIPLMEQPIEQQEPATEAVDDKEADTHSHPDEPKIESITEQELRLQLYHVKKQCQQMHGYYDEQLNAARLKIQEQQLRIQQLESALSITEQHAVKPNIVQRPSGGYINTMCTTSLQPNCYTQPPSSMYEIQPFYFHSNNHHSDTNTNSCLMRPSYVKVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXD6</accession>
    <name>A0A367JXD6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAI1_1</name>
        <name evidence="8" type="ORF">CU097_005409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000563">
        <property type="protein sequence ID" value="RCH94568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXD6"/>
    <dbReference type="STRING" id="86630.A0A367JXD6"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="385" mass="45261" checksum="B04B06E828B9C3EF" modified="2018-11-07" version="1">MSKRSATAQLDEAERIKRNQFSFPLEANERYEGSFPVYKQPQELTCYSIDHHRRVWFDDREMKYYYPPSGKDLNVGYDQFIQRDESVSEHIDTLLDALTTVKQKHPSDIQADIVTWRGIMTKILCTPYSRRDAWELRATRYNGTIFIEEQSLKDNSRDTDRQKLMGYWGYRFETLCTVSQPPHKVNKEELKRRDNESANTNVQYCVVVKTRLGNNSIIMGAEVDCCRDVKPKDPTAQLSNYIELKTSRIIETSRHDYSFQRYKLLKFWAQSFLVGVPRIICGFRNDDGLLMEVKQYKTLEIPRQVRNTKNTWNPAVCLNFANRLLDWIRHNITKDDPTTTYRIEFKSPFEEINIECTGHANVFLTQRFIEGKTLNEIGGQRATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXH3</accession>
    <name>A0A367JXH3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Man1/Src1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000552">
        <property type="protein sequence ID" value="RCH94664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXH3"/>
    <dbReference type="OrthoDB" id="10306706at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="60002" checksum="21C596CBEEF80D5C" modified="2018-11-07" version="1">MCLQIYSEEGVNLRKFQKQELLDILLQNGIEHDPNVGRNQLLRLFNSRIYVNRLQILNEYWQSLQPGTGSDSSSLYFDATNRSFTQTETESDSSNLYVDVNDHFSVGSSPASSALNSTHHSSHSSLEADLPDVSRYGRSSPASIAEPQAGSQAIASGSSQVIASGSPQASSRTRYGFLAPWPFYHQESYLRRPLFSEILSEVPDDDSLAISTNSKLPVATELFGSWIPRPLASDSRGFAAYKPRWRSDVATFPNIFNSGLRYPKTILPPNNYDSSLGYMTRPRGPFAFDVASSSSFQTSSINRRNTAALQRFSRHLTATDFPRATDNREPSGHDNLPPVIESFELPTGSLFRYFVRGTFREFIFFLFRNFVPVLLTLMIYGSMYMDMEITRFISTEQPEIGLLLVPIVLFLSIATITELWRMYHDFIKRRARQRIIDAVVDRILDELKRKCTLWERGSFFHPHSSLPIRYFYNQFILAYPDQADLWEEVFDAIENNRDVKTVRRVEEGEEVDAWDYRPYVLNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXI4</accession>
    <name>A0A367JXI4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000561">
        <property type="protein sequence ID" value="RCH94589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXI4"/>
    <dbReference type="STRING" id="86630.A0A367JXI4"/>
    <dbReference type="OrthoDB" id="2354504at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="60707" checksum="31FE45A562348EE8" modified="2018-11-07" version="1">MSYSDIFLIQSPKSPSENTWYYAPEQLKNRQCEFIERPSPIDTVYNSPTAEVDYMDLIENRIVIEFSTFSELKLALIDSEDTNTSNIVKQTEEEEMRIQNTSTTIPSSVRTDVESSHLLDVLMDQAIQHWCCIGFKIAPIKLEMIENWRQAPWPIVYCVASISLVSFLSRQHLSDFNRHVAMAFYQQARAKMDDILEDSMNPQIIQSYFCLSYTSNLLRLYEHQRTWGGLASISLQHLVKTNSAQIDPVTLSLWIRWYYIDAWLCLTVGRDCLLPDRLPWLDLKTIEQLSISQVVQGDDNQQFGFACIGYYMRKYIRAIQAGKLSNTHPYEPSGYYYQITDSLTRWYSQLPTYSSNSPASRLHLHICYHSMRLVVLYHFLQQPQQSPPESILIDCLTTNLELLQTLDHLKQKGCDQSTYHHMFLAIHNTSKRIFQYKQLHALRSFAEEQLKINLALLKGTQAYTHDAFKMKLYAEMIQNQFDKMNISMEKKQNAMPQILVFKKDASISTKKALKNKRIKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXT9</accession>
    <name>A0A367JXT9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000544">
        <property type="protein sequence ID" value="RCH94743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXT9"/>
    <dbReference type="STRING" id="86630.A0A367JXT9"/>
    <dbReference type="OrthoDB" id="2257689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="239" mass="28856" checksum="A97F7DF6337AE498" modified="2018-11-07" version="1">MIPITPYSQYPFNPQSECLDDNLEKNLRESHERERYLERIIHSQANQLKSPSVENTLHTLKNIYLYNQNESKIQHSNEMERLKNEIDMLSRKRHRLDVITQHLNHLELFTNEDEIQDRKWLLWKIKMNELKLAMKDIELEALYRKQSTNLTNLSLLADKLLKDDNNKKQKMNDDRQQWSRLWSRKEDEMLMEAVQKVGTSDWQRISNYLHERTPHECFERWQTISSNPRKLPSISALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY70</accession>
    <name>A0A367JY70_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000526">
        <property type="protein sequence ID" value="RCH94904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY70"/>
    <dbReference type="STRING" id="86630.A0A367JY70"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="629" mass="68992" checksum="C4D06369AFB0E6B1" modified="2018-11-07" version="1">MGSSTGTSGLFHFMMSDNESGIKRATEQDEQLEALKKQKLGEPEEKKPVQADDIVADNTDTLEVKGNIESDDPTRAVTASPSQTQPNSSDDTAITSEQLLFALTSVPAETKLSPDPVIEKTPEEKPSETTTAKTTSNKQKTPPMISVTEADKNASSVTSSKEKPDENKPTEPLRASASFSPSLSHATSLALNNLPNISAALRRLSNAGVIEQLSSSSSRSTHTGQERKKSIEVTPSEILGNALAVVAASARAANNNSTQSSSIYNNNNSSSSNSNSSNNSNTAAAIGNLAAITANISSFLNSSGFHRGSFSQEDTQKLAAAVASVTNNSNNSNNSSHSTARRNSSIAAVGNAFSNMIDQAMMIRRNKSMSAGTLVQQEPLPKPKLIVKNDQVWKALEGIEEKLLGYQVYSPHRLLPNLENCLNGIMEIRVPARYLTFENVQVKKRAIWGTDIYTDDSDIVAMVIHSGKYEPQYREPEIDPNDPFALAIAGKPREATEAAKKLALSGKKWIRQDALIPDHDLKVTVRVLPRLQSYTGSIRHRIKSRDWKKHDGMSLYVNKVEKIKKGDARLKGRAAIKSRMFAYEPYRKKALGLDMMKKEQEKKMPEERPLQRGRIKKTHRVMRMFQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYD8</accession>
    <name>A0A367JYD8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000553">
        <property type="protein sequence ID" value="RCH94661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYD8"/>
    <dbReference type="STRING" id="86630.A0A367JYD8"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="95" mass="11016" checksum="FD1FBF3D8DEF8379" modified="2018-11-07" version="1">MFHWVQGIPFENNQGAYDGLTLWEQIDGGVQFTATRKFLTAVPIVLFLLSTHYTHYDFFLFGINFTALLVVLVAKLPMMHRVRVFGINKLDYDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYG9</accession>
    <name>A0A367JYG9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000522">
        <property type="protein sequence ID" value="RCH94939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYG9"/>
    <dbReference type="STRING" id="86630.A0A367JYG9"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="18418" checksum="EB1A0991E5A13355" modified="2018-11-07" version="1">MSEIIIRVGIIRARNLAAADKTGFSDPYVVLRVNHKKYKTKAIEQTLDPEWNAHFDIKVAPKKTPTLLSFTVWDKDTFGRDFLGELTIPFKNIFDRNAHGLSDGVPRNYNDPLNYEAYYTLSKRSEKNNVSGEICLKFGFYEEHIGDPKRYADAWELLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYM0</accession>
    <name>A0A367JYM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000502">
        <property type="protein sequence ID" value="RCH95092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYM0"/>
    <dbReference type="STRING" id="86630.A0A367JYM0"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="398" mass="46116" checksum="669EB60B6C4BB171" modified="2018-11-07" version="1">MKRNLTGIAKKLAGPTLLCYTVRFVHLYYSVYLLILLAIVAYLHVHPSHHSLETCRQMSISKRKSLQKSEERFASLKINEFFLNPFDEWKEIPFYKTLLLWSRRWKGNGIPNNEIELDKSLPCKKPCLTHIFKQHDKITFTWFGQSTCLVTIGELTILTDPVFSKRSINDYFGPKRLRPIPCQLEEFIDKVDIVLVSHDHFDHLDENAVRKLGNTVTWYIPLGLGRWFSKRGITRFVELDWWQKVDHQGTTIVCVPAMHWSGSRTPFEKNNTLWCSFVIKSTKHSFFFCGDTGYSPELFQAIGNMYAPFTLAAMPIGSYLPMELMKHLHMGPTDAIQAHRDLGFPRLSIGIHWGTFMMSDENYLAPKKVLEASWQLTKQEVEKESEFITTAFGETIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ84</accession>
    <name>A0A367JZ84_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000488">
        <property type="protein sequence ID" value="RCH95228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ84"/>
    <dbReference type="STRING" id="86630.A0A367JZ84"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="627" mass="72826" checksum="54FB0167D0388BE2" modified="2018-11-07" version="1">MTNKQTPCFECRRKRRKCVRAVPGQSCLRCQKMNKVCPRKEDSVIEPDNELDYLKEQVCELNQAIQRMEHELKTLGTRSPLYIKNNAMTLPRSAIDNLLFNWKVKINNGCFTIETGIKSIGDLLSQQPSLRYLSPLGNYATQLPDGSSALIHFKLQGHGGLFSLAGKIIPKLSTEKRSDEHKLLLGHVMFSSRRLIDKLVDIYFNCHNIYFGWLHESSFRKRYSQLKEPLDDLICASLCCYVCATPCDHLDFNAYQRRDMCDYFYLKAKEKLLDQFDDPDKRLENVIAINMLFSYMHMTLKLIEYDAYMTISTQICYDLQSEYEAAKVQTGIDYALFARHFTQISCVRLTLDCIANKPRSHLPSSLPKMDAFPYEPKETKEYLQVLEWLNEVYSNPVMDKLEEQVHILSLGSICTLSFDTIFKLEQFLTDFRKTIPKELQLCDDIFNEAKCRQALDQSKDSVAIFSFLHFILLIDTVYVTILQPIPTNDENDILLQHIQQIALERSSQMTRLMLYGMRRLCQLKSASRCQVVMVSSMIMLYLIDLLVLQCSSTIEAVVIEGQQRLQECLVAINAIRGIQREHIFPQLLDVKRDIRDFIHSKKVDIDYYDRFPDPWCALLHDISHCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZQ8</accession>
    <name>A0A367JZQ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000470">
        <property type="protein sequence ID" value="RCH95408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZQ8"/>
    <dbReference type="STRING" id="86630.A0A367JZQ8"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="159" mass="18192" checksum="ECA1B870C3C46B77" modified="2018-11-07" version="1">MSKLYDLTVKTIANQDWNLSSLKGKVVLVVNVASKCGFTRQYAGLEELYKKYQPRGFELIGAPCNQFNHQEPGSPEDIQKFCKLTYDVSFPLLEKLDVNGPNEAPLYKFLKESKSGIFGMTRIKWNFEKFLIDRQGNVVKRYSSLTEPSFIAPDIEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0T5</accession>
    <name>A0A367K0T5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000426">
        <property type="protein sequence ID" value="RCH95852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0T5"/>
    <dbReference type="OrthoDB" id="2236387at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="70" mass="8231" checksum="7FE61F6633FCFCA3" modified="2018-11-07" version="1">MSNYEPLDCLPPSYSAVMAEKEMGQWNMNIHQSMYEAQKMINLVQLQCDVLQWKNSCYLKQLKELTARNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0U9</accession>
    <name>A0A367K0U9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000434">
        <property type="protein sequence ID" value="RCH95769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0U9"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8276" checksum="3CF334894D8697C2" modified="2018-11-07" version="1" fragment="single">MQPSLTLRAAHKPLIRFLGPRAALWKDAPHHSGPHPLTPPNLVKHVAQAEPQASVNKAVNSGSIEFGQLPAKYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K172</accession>
    <name>A0A367K172_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000416">
        <property type="protein sequence ID" value="RCH95954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K172"/>
    <dbReference type="STRING" id="86630.A0A367K172"/>
    <dbReference type="OrthoDB" id="2275544at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="98" mass="11261" checksum="A6EB6A5AB69D0B22" modified="2018-11-07" version="1">MDGFITERQEPDGRIRRKGEMRLVNNTKTIFLKFKLEIYQLLAAKKRGLYRISFIQQQGDAMALAAAVRIVDRTLQVYEQEAELVSAANGWSINRVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1D5</accession>
    <name>A0A367K1D5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000413">
        <property type="protein sequence ID" value="RCH95990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1D5"/>
    <dbReference type="STRING" id="86630.A0A367K1D5"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="91" mass="10121" checksum="A3F9C49B7DE1AC7C" modified="2018-11-07" version="1">MPGPATLFTLGAVGAAAVYANRRHSMSSAEKDENTPYALARRSSSNTPIDHTWDPRMQAEHVWRRNNGVSFGHNSNPKFPLKNKDIQQTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1Q5</accession>
    <name>A0A367K1Q5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000401">
        <property type="protein sequence ID" value="RCH96106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1Q5"/>
    <dbReference type="OrthoDB" id="2380640at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="15664" checksum="CA58A0E30A995654" modified="2018-11-07" version="1">MMCDTNWCTFCDNAISPYSDSLYCSEECLRQDALRHHPMLGYDYAELNGFPHINNSTYKSNNRRISTNTTTTASSPSNASNYFSQLHKLPSLSPSLSSSPSSIYSAQEDNHDLTTYSYYQPKPRRTSVPLEHQQALHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2R6</accession>
    <name>A0A367K2R6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000394">
        <property type="protein sequence ID" value="RCH96181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2R6"/>
    <dbReference type="STRING" id="86630.A0A367K2R6"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="211"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="6">
        <location>
            <begin position="524"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="408"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="597" mass="67942" checksum="C894A0A20EF3F565" modified="2018-11-07" version="1">MTELCLTKATVKLPKKTRNNSCLREIVSDILVKERVYFDGCKVTKDDIIVLFKDYDPIKVDINQIEGNVCSGYIQFRTKEIADRVYALFNCIKSDVELQLKINPPYKVEPEVEANVLYIQNLSDKMSPGLIYDLFRPFGPINSCKMSEGSTTALLQYFKSKNAYDAQRTMNGKLIHNNVITVTHLNTTKLQTTELKTNTKAAKSNIPVDYTNLYIKNLDLEVKSADLFKHFRKYGHIISARVMKHPQTKQSRGFGFVSFSKTEEAMQAKEGMNGQFIASKPIIVAFHEPKKAKSEDNQSPDSNSSNHSAPVASYHPRSTTPTDKLKYSSSMNSNAYNNGLPLKRQVSAPIHHQPTYTPSGLFIPAPLPTQQNRPTLRRSGSIESVTTAMTETNTQLKRQAIIQAIFTMNQQEQNLQDIVDMLLTLKKKDLATCLFNKAFLLTKIKQAKEALEIFQEEEQQQQPFQQQHQQQQQQQVQMQNFYYHLPNIEIPPRCSRAIPIVAPPDAGVKPKKQKESDSKDLKEEIEKFLETLKDLASYEQKQLLGDRLFPLVKATGVKHAPRVTIRLLDTIPIQELAHSMYDKHKLQQLVNNAPINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Z3</accession>
    <name>A0A367K3Z3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000330">
        <property type="protein sequence ID" value="RCH96865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Z3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="79" mass="8947" checksum="D2C8A60A41ABAB77" modified="2018-11-07" version="1">MSSVSSADESDGIICSYKSADKSHLPSFVIKSSQQRPLIPRIKECTEPKPTTSYRDWMDDIESERRVLGRLIIMCLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K444</accession>
    <name>A0A367K444_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_010618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000314">
        <property type="protein sequence ID" value="RCH97032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K444"/>
    <dbReference type="STRING" id="86630.A0A367K444"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051306">
        <property type="entry name" value="Homeobox_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123">
        <property type="entry name" value="MIX-TYPE HOMEOBOX GENE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123:SF4">
        <property type="entry name" value="MIX-TYPE HOMEOBOX GENE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH97032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="395" mass="45343" checksum="08126B4374814FFF" modified="2018-11-07" version="1">MEASTRKRTHLSSSQVSTLEASFKENSLPDSTTRSRLAKELSVTERTVQIWFQNRRAKEKKMRARFTEDHKREPTAPRYQPTFRSMMTPEAFEQPNESDSIQKRPRSISKPEKPKASLQLTSEQEQYSRALSEGLTSSNSNSSHQGTFQSHGLSPYIHYPFLASSLGSKHIPPVISLAPNILRIGTWTRFSSEQHQDWDLCCYAVPSDRIFVWKVKAGQHQFKIEILFDQIQYIHLHAIGQLDIHLSSLPLSFAMLRYQQDQDWVPCGDFTEMQQASMVPIHTLQGNYESFKYALLDLMMFAPELSTKLINTVDLPGLDDIGREYTLSPSATPEPFMMQYTESSKLRANTTPIHHLMLQAPFFYPTQSPLDEDMSHSVEYYTPPPPLNSYHTSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K548</accession>
    <name>A0A367K548_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000291">
        <property type="protein sequence ID" value="RCH97279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K548"/>
    <dbReference type="STRING" id="86630.A0A367K548"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="73"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="213" mass="24789" checksum="A341ADFAB28A490A" modified="2018-11-07" version="1">MHIKRPQLSLSLLRHSEINSDKKELVFNSFQRKKGHTKKNVYLNEQHSRPSLNLSITNDSRLKDELLPSYSCTVHKVGICHAKIEVDSLGAKPWRRPWRHIFMELRGTFLQIYEIKTFKPLYLPTFPADYQQTFKWIPLINLSLSQLEAVVADDYKKRSNVFRIIDSSLRLLIQVQTMAEMRSWMEKISAGKNIAVDFVYPPILTIDCLGCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K645</accession>
    <name>A0A367K645_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000262">
        <property type="protein sequence ID" value="RCH97626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K645"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9649" checksum="AA7D3BB10B3D198F" modified="2018-11-07" version="1">MLFYGNSRTDFASSKRKEQICDKSKKKVSLSVSRYIHPIGSIWRLSRTWESYEDKHQCPTLTYPSMISLTLPSQSLAPLIALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6H1</accession>
    <name>A0A367K6H1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLU7_1</name>
        <name evidence="10" type="ORF">CU097_006592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000245">
        <property type="protein sequence ID" value="RCH97823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6H1"/>
    <dbReference type="STRING" id="86630.A0A367K6H1"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="139"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="433" mass="49768" checksum="7214A9A9508BD3D5" modified="2018-11-07" version="1">MQQTRLTKEEYRQAKDLDAARKAGTAPAEVDDEGNEINPHTPQFMLKAPWYVDTGKVSLKHQKAPEKRSANKFTADDNYWYARGKRAGPAATKYRKGACENCGAMTHKTKDCVERPRKKGAKWTGENIKADEIIQNVELDWDEKRDRWNGYDPREHDKVIEEYNKIEEARRKFKATELDKQGPTTTSEAKKIAGISDDEDEEDDDKYADAADMPGQHVNQKTRTTIRNLRIREDTAKYLLNLDPESAFYDPKTRSMRENPLKDKKADSLDYAGDNFVRYTGETPEMAKVQMFAWQASERGNEVHLQANPTQVALLHKQYESKKDEVREATQKSILEKYGGEEYLEAPPKELLLAQTENYVEYSRTGRVIKGQERAKAKSKYEEDVYINNHTTVWGSYWLEGKWGYKCCRSFVRNSYCTGAAGIEAQKAAQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6K9</accession>
    <name>A0A367K6K9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000246">
        <property type="protein sequence ID" value="RCH97808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6K9"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33665" checksum="DD404B05B8AEC09A" modified="2018-11-07" version="1">MQPIFQTTEMSKGSRECVPLDDKTTLMITIFLCFGIVVSYLPQHYRIIANKTSEGFSAWFLLLGVISSSSSLLNIIVLQWDAIVCCKSLSTGACLEGLMGIVQIGIQWSMFCLVFFLYLIYFPENKKREPHAPTSLHLEFPNKIQPPISAEWKMSLLVATLCIGHLAVSFFISVLLLIIVGGPEHWLTNYWAGFLGVLSMLFASFQYIPQIWKTWNSKVVGALSIPMMMLQTPGTVLFMYALIVRPGTNWTAWIPYLATCILQGVLLTMCIAWHFRNKRLNISDLDGAPEPTEATRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K854</accession>
    <name>A0A367K854_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000202">
        <property type="protein sequence ID" value="RCH98368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K854"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="46548" checksum="A057B86AE09D52EB" modified="2018-11-07" version="1">MPAKKDYIQLPTSPTISASEPNDAFSSAVPFEDAVSELPPYRSLTTEPQSTVGTSSSKNNDHVYIDPNVGDAEDASCNIQTGSEPADHAIVMIPDDHQLEYEEYNPPPGYSVHMAEYRVTSKGKVRTRDRHVNEDPEALLQFLYQHNTPPTLIIRFKGFCEETRWVTKTRRNYQGEEETDHVSETQRVDGFDFKIDTSQYVSSTSQGIYVLPNNNETTPKVRQLCNDYVRSKNVLKELKLTKEINWDFQKLAEGKSRNDHKRLSYQLLYEKALKNAIRSTGEFEGIEITFKTEKEEIIVKPNNWVSCIVDSIVFKILMFITCFWVFTVPFTFLYGKKFGHSNLRSGWNMTISEKAWYQQHAREIVAMCRNRIINRNQITKLTPIPPFPDMPGSSHPSDHIYEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K894</accession>
    <name>A0A367K894_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ILV2_2</name>
        <name evidence="17" type="ORF">CU097_014627</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="PJQL01000196">
        <property type="protein sequence ID" value="RCH98452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K894"/>
    <dbReference type="STRING" id="86630.A0A367K894"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="86"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="289"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="496"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH98452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="679" mass="74080" checksum="4FB81A48EC197BD8" modified="2018-11-07" version="1">MLAASRASRGFNKLKSFTSLPLNNNRAVISACVHTSHKLKGAAASPSISNTDRSAVATPKSPSTVHPLNSTKKPSASEMDDSFVGMSGGEIFHEMMLRHDVKHVFGYPGGAILPVFDAIYESKYFNFILPRHEQGAGHMAEGYARATGKPGVVLVTSGPGATNVMTPLADALADGIPLVVFCGQVPTSAIGTDAFQEADIVGISRSCTKWNVMVKDIAELPRRINEAFTIATSGRPGPVLVDLPKDVTAAILKRPIPTNALIPSRPTTIPNTAIGAFTEEARSHAVPTLKRAIDMINKAKRPVIYAGQGITGHPDGPKMLRALANNGNIPVTTTFQGLGTFDELDKKSLHMLGMHGSCYANLAMQNADLIIALGARFDDRVTGNVKAFAPEAIKAAKEGRGGILHFEIMPKNINKVVEATEAIEGDVTENLKQILPHIKGAERKEWFDQIDDWKNKYPFYYEKTTDDSQPLKPQQLIEELDLQTRDKKDKVIITTGVGQHQMWACQYYRWTHPRTFISSGGLGTMGYGLPSAIGAKVAKPDHIVVDIDGDASFSMTAMELATAAEFNIGVKVLLLNNSFQGMVKQWQDLFYKERYSGTIMKNPDFVKLAESMGIKALRVTKASEIQSKMKEFLEYDGPIVMDAVVCKKEVLWPMVPAGRALDDFLVHPHIAERNKSNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8N5</accession>
    <name>A0A367K8N5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPT3 Dosage dependent suppressor of Ty-induced promoter mutations-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPT23_5</name>
        <name evidence="3" type="ORF">CU097_011431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000191">
        <property type="protein sequence ID" value="RCH98520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8N5"/>
    <dbReference type="STRING" id="86630.A0A367K8N5"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="2">
        <location>
            <begin position="178"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="32279" checksum="96EDBD1EE1049295" modified="2018-11-07" version="1">MSTPFEPNQGPIGVDNEISLLKHEQQPQNDQVMHLFLNQVADYNTFDHHQPQQGSSSSSNSNSGHNNNNNNNNNNVFAAHKDSAIEEFITLPNNNSNANKKGKQKSKEGGHTSLLQVLTNPLLHAIPILARNCLNFEDFLAQTSMPGHNGLLGSMDELDNHNAETDLAPSPMIKSDTPWHIRVLGLPHTGAKSRVETQIKICLQLVDAQGELATNWSHVKLPGHLVAKDKLKRRNQKYGPEEKATLIESQVLSLEAAVVCESHPDDQIIMCPSCVHREVSLMSIYDAMSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8W5</accession>
    <name>A0A367K8W5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000185">
        <property type="protein sequence ID" value="RCH98600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8W5"/>
    <dbReference type="STRING" id="86630.A0A367K8W5"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000002">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001859">
        <property type="entry name" value="PRK00591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="383" mass="43542" checksum="55CA35ED5A9CB63C" modified="2018-11-07" version="1">MFRKSFQFVARYSTKGCRFASSSKITPTLENKLLRLSQRHDTIISQLNNSNEIDSVELANASKELASLTETKELFDRWQKTIKDLQELGTILSTGDEEMQELAKEEYEEMTDQIKALEKDIIIQLAPKDAADETSAILEIRAGAGGDEASIFSADMARMYERFAQLQRWKWEVLACSEETGSKGFKDITVNVGGKNVFGLLKYESGVHRVQRVPATESQGRIHTSTVTVAIMPQPTEVQVQIRDSDLKIDVYRASGAGGQHVNTTDSAVRVTHIPTGLVVSMQDERSQHKNKQKALKVLRAKIYEQERIKTEQNRRESRNKQIGTGDRSEKIRTYNYPQNRVTDHRINLTLYELENIMSGESLLNIIRPLQEHYLIESLTEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAA3</accession>
    <name>A0A367KAA3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000147">
        <property type="protein sequence ID" value="RCH99096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAA3"/>
    <dbReference type="STRING" id="86630.A0A367KAA3"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="145"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="569" mass="64597" checksum="BD999DFC80E5BB28" modified="2018-11-07" version="1">MDISDPLEHAEHIVDLFHVIINRLGYYFLTLSRGAFHDQPLNAGQIVSKAIDEPYSSCLPVRGASFHTRASQMRASQFGWQMFGIQEQLGAPTMFFLLRASDLNAKWTFLTPEITFMAISTELQHQFEEEPPETHVLHKKLSGARMFVLNRPEKLNALNLSMIRNIGPQLKAWEVSTLAKVIIMKSTGKGKFSVGDDILDILQKANARDPDALYFFQDKFSLVQMIATLQTPYISILDGYALGGALGLFIHGPFRIATERTIFALPETSIGAFLSSGSSFYLPRLDGEIGTYLALTGSRVEGIDTFFSGIATHYIPSSRIPALEDRLIDLETSEHEIIQRVLEKFVEPKSVSKVGFQKEIREVIDRCFAHDTIEDIINALDREKSTVWTRETKQKLLSLSPTSLKVTLKALRKGRSMSLVDCLKMEFDLIQKFLVTRDFHEGVEAMFLSKPRRKPRWEPSRLGDISDEEIDQLYFNQPAPNQLILPSKKDLRHYPYARYSLPTEEDVRLAITGEGPEFKLEGRLKAQEDIISWFVSGHRGKWGVKEKVQDILDRKAEVLTEQDGVVWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAJ1</accession>
    <name>A0A367KAJ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PCK1_4</name>
        <name evidence="12" type="ORF">CU097_015349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000135">
        <property type="protein sequence ID" value="RCH99263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAJ1"/>
    <dbReference type="STRING" id="86630.A0A367KAJ1"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH99263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="553" mass="61108" checksum="9356F3EA6822D4E5" modified="2018-11-07" version="1">MVASRPGSPYTGRPASSGSVHTKVEEELHEVAGIDYDKVTIKRNPSVAVLYEEALTYEQGTVISSAGALCAYSGKKTGRSPKDKRIVEEETSQKDVWWGPVNTPISERVFLINRERAIDYLNTRPRLYVFDGFAGWDPKYRKKVRVVASRAYHILFMRNMLIRPTEEELENFGTPDFTIFNAGEFPANRYTTGMTSTTSVSVNFKRNEMVILGTEYAGEMKKGIFTVMHYLMPKAGVLSLHSSANEGPDGDVSLFFGLSGTGKTTLSADPKRKLIGDDEHCWSDDGIFNIEGGCYAKCIDLSAEKEPDIFNAIRFGAILENVVLDEETRVVDYSDDFLTENTRCAYPIYHIPNAKLPCMGGHPKNIILLTCDAFGVLPPVSKLTAEQAMYHFISGYTTKVPGTEDGIVEPQATFSACFGAPFLVLHPQRYASMLAEKMSKHKADAWLINTGWIGGSAATSKRCPLKYTRAILDAIHSGELAKAEYETLEIFNLSIPKAVSGVPSELLNPKTAWNGTPEQFKSSLQNVAKMFVENFKTYEDQAAPQTLAAGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAQ2</accession>
    <name>A0A367KAQ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000136">
        <property type="protein sequence ID" value="RCH99247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAQ2"/>
    <dbReference type="OrthoDB" id="2273778at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15975" checksum="EC153A71BCC945F0" modified="2018-11-07" version="1">MFAYQDHILFRWDTSSEVYNESKKKKRPDFIICTSDGIEVGCGEIKPPDTNSSDVEEDHCQVPEHLKKQLHKRLQVASEEKELATLGFIIFSEELELSKMEFKEGKYEYSIIKLLKLPTMCATFQHMDESSYLNFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB94</accession>
    <name>A0A367KB94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KRE2_8</name>
        <name evidence="5" type="ORF">CU097_010133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000120">
        <property type="protein sequence ID" value="RCH99485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB94"/>
    <dbReference type="STRING" id="86630.A0A367KB94"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="371" mass="44276" checksum="DBE6B269C6E77D33" modified="2018-11-07" version="1">MYKQYRATLLFIVTFISFLGLFYYYYFHYGPGSSTNPTLVQPSIKDDPNLINPHHLQWKNKTRANAAFVILTRNGELETLRKTIQQLEARFNHKFNYPYVFLNDVEFTQEFKELTSSMTSSKTEYGLIPKEHWSYPDWIDIPKADEARRKMAEAGIIYGDSLSYRHMCRFNSGFFYRHPLVEKYEYYWRVEPGVEFMCDIDYDPFLYMKENNKKYGWTISLIEYESTIPTLWKTVVSFMQKYPQYIPKNNLLDFISYDGGRSYNLCHFWSNFEIADLKFLRSPEYSAFFDYLDKTGGFFYERWGDAPVHSIAAGIFLNKSEVYFFNNIGYRHEPFEHCPLARELQKKCHCSAEDSFDNTPHSCLRRWMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBA7</accession>
    <name>A0A367KBA7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FADB2X_3</name>
        <name evidence="4" type="ORF">CU097_014948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000145">
        <property type="protein sequence ID" value="RCH99121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBA7"/>
    <dbReference type="STRING" id="86630.A0A367KBA7"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="256" mass="27547" checksum="F3ED3954EF889544" modified="2018-11-07" version="1">MQIKEHVFIVTGGASGLGEQVVRAIIDAGGYISIFDINQKGSTSLVDEYTNHVCYFPGSVDVTSESQVKEAVIKTRKHFSKNTIAGTIICSGILNAPYQGYGPDNMLTSYSQFEHIIKVNLLGTYCVAQKVSEILLQNEPMDNDGERGIIITVASIVGLDGMVVGYGTSKAAIAGLTLPLARELAPFGIRVMSIAPGPFDTPMVSHIPIDTNRLTFPKRVGRPSEFAELVLDVIKKPMLNGSVIRLDGGLRASNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCF2</accession>
    <name>A0A367KCF2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_008117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000093">
        <property type="protein sequence ID" value="RCH99885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCF2"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="98"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="310"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="448" mass="49228" checksum="FA97738DCF508C01" modified="2018-11-07" version="1">MPPNEYHDTIELISKAENNTLQIPKHKHTRTGSSSSFIHFRAPLNEESQPMANPNQLASQALPSLIICIIGLTAAGWMMDIYQHWEVFTQVSELFILVPVLLNLKGNLEMNLAARFSTSANMGQLDHPDTRNALVWGNMALIQVQALVSGSIAGIFSLLLGLLLHPDETVTISNIILVISSSMVAASVSSFVLGLFMCILIIISRILKIDPDNIACPMASSLGDVVTLAILAGCANLLLDKTVSNLGSWLLFIMFSSIPFFGLAVWRNTHVRGLLFTGWTPIVIAMLISSGAGLVLERYVEQYQGLAMLTPILCGLAGNLGSIYASRISTCLHKGVQEQFRRVEWILLSMNVPIQSLFLAIVWFIDIGHLDLSLAFAITYFIVSVISTLAALKMGKSMTLAFWKYKYDPDNYVLPYLTAIIDVICTSLLVISFSWLTATGYAHLHEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD79</accession>
    <name>A0A367KD79_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000077">
        <property type="protein sequence ID" value="RCI00156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD79"/>
    <dbReference type="STRING" id="86630.A0A367KD79"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016952477" description="Phospholipase B1, membrane-associated" evidence="1">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41768" checksum="51FF9C146C685B80" modified="2018-11-07" version="1">MRYLFIVTFTILISILAVNGAYQYAERIEDCPQLQPRTPPTSVRDLRADDIKAVGALGDSIMAGAVSKGLQGSRTLNINVALEERGITYGAGADPGAITIPNYIKHYNPNVIGGSVGEHWVEFCYFGLCPKWQYHPEKDNFNAAQSAAMSFDLGMELDYLIPAMKTTQGLDFENDWKMITIQIGSVDQCYICSIYGPLITPEGYEKSLDSALRRIRKEVPRVLVNLIGVFNVTNVYELTTGNPYCNATIFGDFQTNSLECFCATHGFKKEVDMAAVAFDSIVFKLAKKYNELNDPTFGIMYTPARVDLATLPIQMYSDGDCFHPSISGHETFAKTYWNTFWKPLENIPSLYTVNDYNKVICPSEEDRFQLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEN8</accession>
    <name>A0A367KEN8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TIM9_3</name>
        <name evidence="12" type="ORF">CU097_014284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000052">
        <property type="protein sequence ID" value="RCI00580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEN8"/>
    <dbReference type="STRING" id="86630.A0A367KEN8"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9770" checksum="5299332562719E50" modified="2018-11-07" version="1">MDFSRFNQAEQAQIAAMIEHKQMRDFMKLYSSLVQRCFDDCTNDFTTKSLNSKEESCVNKCADKFFKHSERVGARFAELSQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFL1</accession>
    <name>A0A367KFL1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000031">
        <property type="protein sequence ID" value="RCI00969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFL1"/>
    <dbReference type="STRING" id="86630.A0A367KFL1"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="77"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="269" mass="31792" checksum="BEE63CC3F6D8A52E" modified="2018-11-07" version="1">MLSRVSKSYLTTRTLYTTARLARPFPTLSLKEQEPAPPKQGRANEIIEAVLYGSKKTREEENQTHSKVLARGKYVHELQVHNVKPDKVNEYTELVSKYMPLIANDPANNLHLCGSWSVEIGEQDTFVHIWEYKGYPGHKHTMERLSKDEAYNEFMNRLRPLLVSRQNNMMLEFSFWMTSPPKVTNNIYELRKYTLKPGRLLEWEMYWRRGLECRRKFCEPVGAWFTQLGELNTVYHMWTYPDLQTRKTTREDAWNTEGWAETVQKTGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFT5</accession>
    <name>A0A367KFT5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL7_5</name>
        <name evidence="7" type="ORF">CU097_012974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000026">
        <property type="protein sequence ID" value="RCI01076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFT5"/>
    <dbReference type="STRING" id="86630.A0A367KFT5"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="253" mass="29563" checksum="81827D9841BA864E" modified="2018-11-07" version="1">MSYTTPTRDQVYVPETLLKKQKTTEKANAERALQLAQEKKEKKDNRKIIFKKADAYVKEYRQKEQDTVRLRRQAKQAGNFYIPSQPILLFVIRIRGITDVHPKVKKVLQLFRLLQINNGVFVRVNKATLQMLQVIEPYVTYGPPNLKTVRELIYKRGYIKSKEGHRLPITDNQLIKDHLGQFGIICVEDVIHEIVTVGDHFKQVNNFLWPFKLSNPNGHKKASWKPHKFQHYVEGGDAGDREFDINRLIQSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG61</accession>
    <name>A0A367KG61_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000038">
        <property type="protein sequence ID" value="RCI00832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG61"/>
    <dbReference type="STRING" id="86630.A0A367KG61"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="289" mass="34656" checksum="D221A42EAF6DD70E" modified="2018-11-07" version="1">MSELSPPSSKMADDYPPPPPPANNGVPPPSSSSSSVGRRERSPGRDRSLSPRRRSPSAGGRYYDDRRSYRDDDRYHRDRYDYPRRDYYHRDDRYDRDRYDRDRYDHRDRYDRYDHRYEHRDRYERYDDRRGRYPPKARARRPVERGTEQDRKSSTTIYAGNLPYDFIERDVATMFERYGRLKSVTVPMDTVTNKNKGFAFIEFEDRRDAEDAFEKFDGFSVEGRRLRLDWDIGLSKKEQHRPARRSTNGPPPMDDPRDRNMSDPYSAPPPPPPMDSRGYRRDSPEPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGE0</accession>
    <name>A0A367KGE0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_015261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000019">
        <property type="protein sequence ID" value="RCI01238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGE0"/>
    <dbReference type="STRING" id="86630.A0A367KGE0"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI01238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16634" checksum="A839E64422820A8B" modified="2018-11-07" version="1">MLVSKQNRKVIYEALFKDGALVAPKDYNAPKHTELDVPNLEVIKVMQSLTSKGLVKTQFSWQWYYYTLTDEGIDYLREYLHLPQEIVPATLKKTARPATAPRRTFGGDREGRAPRGDRDNYRRKEGASGDFKPEFRGGLGRANRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH06</accession>
    <name>A0A367KH06_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000024">
        <property type="protein sequence ID" value="RCI01132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH06"/>
    <dbReference type="STRING" id="86630.A0A367KH06"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26269" checksum="3A0CAD16A7CE7CE6" modified="2018-11-07" version="1">MSIKNILLQVSEQGGDIIKDIWYLASAVVMSSVNHPEDIQHIYDIVSDNVNKIPNKTREEKNRLVSKIILRLREGVFKSHVIVGFPKTINALQTLSKVTPEEIKALLPNKPLRKEETWSDVQNERQRGKALFDKIYDKHTDKVYNNMYNAYPDLAQTALHHLYGPTLAESSVLNAKETSLVVVSSLMVQNVPLQLKGHLYGASHNGATQAEIDGVKDLVSKLADYYKVHVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH87</accession>
    <name>A0A367KH87_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000003">
        <property type="protein sequence ID" value="RCI01595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH87"/>
    <dbReference type="OrthoDB" id="2445127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="34017" checksum="F6EF3F2194689194" modified="2018-11-07" version="1">MTSYSIEGTGLHRLEAIKNEISNINSLIHNRPEPNDGIDSQQSDRTSITELEATRQTMQKLEEGWETIHQNNLINYRKQKAVNELLRRLQHTGQLHYTACQQLEHSEANLREIQTSIGQIQNTALNLINTLAALEQQIDQANREHQIKEFEQWKENEEKELMNEIAARRTLLVEKENKLKKEYEEYESIQKKKKLELYEATFNAELEDYKRRRETEISSLYNRRNMTSVQTSLEQLQLVDENKGDLDDFLGTSEANKTIATTSDIKELKDDLSSSEDERADILRDEDYDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHL4</accession>
    <name>A0A367KHL4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHL4"/>
    <dbReference type="STRING" id="86630.A0A367KHL4"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="464" mass="53702" checksum="D9DB4379CDB472AA" modified="2018-11-07" version="1">MMVRSSRFIWAVCLTTLVFIMFLVTYTTTQSVSFQLRFSVKPMTKHTQNTSANEDTEKYITYYPHSGLHNQRLALINAIVLAKAMNRTLILPEINIGRATSWAPYYRYEQKIAICPTYYKTADDCADFRRYVPLPAEAIFDLSAARAQGVRIIYRTSMSTTYFQDEWSATDDDIYRIKDEVRLSYRLYDSKENNDSMRNFTERVDVQDLAERQERFIVFGSLHYTHRLALSDPQLIWFRHHLQQEVSIGHPVVIKQALRVLSKLGGPDNFVGVHLRQGDGFFKKAMAETVNAVRLALEQDTLSNMQTDQVTIPNTRPLTDEEENMVQELQQIRNPDALLVQCLKIHRKDNHPRLRLIYMATDTRQPRTTLRDLHQEFPCLFTLSDFPDIIQDILSAQPMPIGDKYIDSVYDQVGTTINPLLIPMVDAEITSHGSAFIGTKKSTFSSYIFNRYNRFQSMYAPLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKH0</accession>
    <name>A0A367IKH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005403">
        <property type="protein sequence ID" value="RCH78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKH0"/>
    <dbReference type="STRING" id="86630.A0A367IKH0"/>
    <dbReference type="OrthoDB" id="2269117at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="10551" checksum="A9EDDC14EE63AFCD" modified="2018-11-07" version="1" fragment="single">ERWNPTQSVESVLVSIISLLADPNCSSPANVDAGVDYRKNRELFESIVKKQVEASKKDIPKGFKMPESEKDFMPTAPPEIEEDDNFWYESGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKM5</accession>
    <name>A0A367IKM5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005366">
        <property type="protein sequence ID" value="RCH78183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKM5"/>
    <dbReference type="STRING" id="86630.A0A367IKM5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="179" mass="17180" checksum="E4F26512E950DE37" modified="2018-11-07" version="1" fragment="single">STTGFGFGASQPSSTSSGFSLAAPTTSNTPFGTATSQPAAGTTSFGFGTSQPSTSTTGFGFGTSQPATSSTGFGFGTSQPSTSSTGFGFGTSQPATSTTGFGFGTSQPATSTSSFGLVTSQPTATTTSFGLGTTQPSTGTTSFSLGTSQPSTGTTGFGFGASQPANTTNTFGSFGTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMV0</accession>
    <name>A0A367IMV0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CorA metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MNR2_1</name>
        <name evidence="7" type="ORF">CU097_000755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004755">
        <property type="protein sequence ID" value="RCH79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMV0"/>
    <dbReference type="STRING" id="86630.A0A367IMV0"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="303" mass="35054" checksum="F10199D6D50473E4" modified="2018-11-07" version="1" fragment="single">DIQAQESREKCEIFQHYMFVSFRTFNQDFNSPNYLDAINFYIIVFKDGVLTFHFQDSPHPRNVRRRIHQLKDFIKVTPEWINYALIDNITDGFAPLIQHTELEVDSIDDLVLVLNGSEQNDMLRRIGSCRKTVMQLIRLLGPKADVLRSLIKRYEDKAKEMEYNNMRALEPNNTGVDSPPEHDEVKVHHDVTLYLGDIQDHIITMLQNVSHYDLILGRAHRNYIGQITIELSQAGNTTNEVINRLTFFATIIVPLNLVGGLFGMNVHVPGQNENDLTWFFWIVMGMLIYVVAMMAIGKRTGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN47</accession>
    <name>A0A367IN47_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folylpolyglutamate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MET7_2</name>
        <name evidence="5" type="ORF">CU097_002250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004697">
        <property type="protein sequence ID" value="RCH79112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN47"/>
    <dbReference type="STRING" id="86630.A0A367IN47"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH79112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="219" mass="24814" checksum="573B8CEAB1D68378" modified="2018-11-07" version="1" fragment="single">SNAAVLEQLRKAGPRMNERSLPEMREYFKRIGYEPQDFDKLNLIHVTGTKGKGSTCALVQSVLHNYDPSIKTGLFTSPHLVAVRERIRINGKPISEELFAKYFHDVWDRLEATKEEAIRAMDLPEADKREMIKNTRQHPDKPVYFRYLTLVAFHTFMQEKVDCAILEVGVGGEYDSTNIIEKPIVCGITALGLDHVSVLGNTIDQIAWHKAGIIKPQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITD7</accession>
    <name>A0A367ITD7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">USP36_2</name>
        <name evidence="9" type="ORF">CU097_003164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01003675">
        <property type="protein sequence ID" value="RCH80909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITD7"/>
    <dbReference type="STRING" id="86630.A0A367ITD7"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="41"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH80909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="53435" checksum="5C979B5AD76EF1B0" modified="2018-11-07" version="1">MTKIFKKQNQKNNKPSPASKFIPFDRSKLQFSWSFKRKIGPGFINMFNTCFLNSVLACLTYTAPLSQYLLTNDHKENCIKEGFCALCAMTEHVYKCFKTLKSLTPLSAISLNYFTSNLKRISSRLTLGRQEDAHEFFMFLLDAFQNSYTPAKSKLTPEQEENGLVHHIFGGKLQSQVTCDNCNAKSNSYDRYLDLSVQLNGAESIEDALKSYIQTDVIGGDNPSENGYNCEQCKQKVKAYKQMTISEIPNNLIIHLKRFEYDFHADSMVKLKQRIRYPTILNMAPYMSEEKHVEKAIYRLYAVLVHQGSTCDSGHYYAYVRNSGGSWYLINDEEVCHVGVKEVMKQQAYMLFYEQKEMLANNKDVTNSKMNKKHQEQKLALTELDLPDELHAKKCLKRSRDDSSEDEAKAKKVKFVELDDTVVATDPDAWVVRSAGVPHRSLYGNQSPRTYSNAVGHISQWTVRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITV8</accession>
    <name>A0A367ITV8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003567">
        <property type="protein sequence ID" value="RCH81134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITV8"/>
    <dbReference type="OrthoDB" id="10513668at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="320" mass="36375" checksum="66C4AE66D3A0F091" modified="2018-11-07" version="1" fragment="single">MEDVYGSPIDDKTFNTARDHLIFFRLPATIRQVKDEFKIKADSDSFCPFACLSWFLGRQVDASLPLASWRKEVFCHTKQCARWKDVEADSDSAAEEQDLHPPSSPVKESDSSGETVSQVHPVSESTTLKEKKHLQPSSSDDNEPAGRNEKKRLQPLSLDNAVYAGKNELENYIASTKKPRFSNFVVENKENLVNWSSEKSFFDQDQLFTLWKQRFALTSKTDKEVWTTIREIVAAKEKAHDRFTIAGLNTLASMSQSVERSQADYIKSLEKQSSAQEINDNNTQEVADTTTQELDDERNDSITQEVGDESDATTYFHETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUN1</accession>
    <name>A0A367IUN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003452">
        <property type="protein sequence ID" value="RCH81400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUN1"/>
    <dbReference type="STRING" id="86630.A0A367IUN1"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF35">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="144"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH81400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="260" mass="30288" checksum="40A415F40F90E300" modified="2018-11-07" version="1">MLFFQFDMLNVLVGICSITACAVIIFREARPDTKLNYSKFAINGPSCGKMLPSRTGMFMIYCPAFVISLISTCQLIITNTFELQNNYRVLLMSVLILLHYGKRLFEVRFIHHYSGHCRLRDCFTIASSYVGLTVLVKIFTEQVPLSYVCSHLNLLGVVCFIIGECVNFYHHVLLKNLRKDGSKEYKIPKHGLFEYVWCPHYLAEVITFFSMVMISQHWIIFILSVGSSLYLAIRAYNTREWYKQRFDKIPTRYCLIPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVJ9</accession>
    <name>A0A367IVJ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003310">
        <property type="protein sequence ID" value="RCH81723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVJ9"/>
    <dbReference type="STRING" id="86630.A0A367IVJ9"/>
    <dbReference type="OrthoDB" id="2236419at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31324" checksum="3C0442ED9CD1FA5B" modified="2018-11-07" version="1">MNFFYEDGRGGIVDDFGNEAAAFVVDPKRRAKRHGYAGSNHQEGKKLNLFYTNEDRLRYFFFLHEKLMKPAEAAKLANVNPETARKWKREYERDPEKKIPFKKTNHISNRAPSQLNENHKMHLINFFDENPSAVIQDAVENLTKSFEGLEIKKSRVAEFMKEDCNLSIKVVTRHPMDRNSQKTLEARANWIEEWQNKGLHFMKNCVFLDEAGFDVNMRRSRGWAQRGKPAIEETTSARGVSHTVIGAVSAFGVVNKHERAGQCQEKKSCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVK9</accession>
    <name>A0A367IVK9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003314">
        <property type="protein sequence ID" value="RCH81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVK9"/>
    <dbReference type="STRING" id="86630.A0A367IVK9"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39245" checksum="4E3E27C91EADB796" modified="2018-11-07" version="1">MSTMTTMLKRRFLAKAINTSARFISTANKGNYAFAFDIDGVLIKGKRRIPEATRALKQLNGDNSANRKVPFVLLTNGGGMTEEEKAKQISEIVGVKIDPKCVILSHSPMQNLAEKYGNKRVLVVGGTGRNCYNVATKYGFQDVVIPHDVMHWNNSVWPHTETVSDLSVLTSSHPIEFSQHPIHAVMVFHDSFEWGRDLQIMLDALCSKGGILGTRKEDYSVQDVPLYWSNIWSTDFPAPRLGQGAFKHALEGLYNTLTGHGLKSTSFGKPHAATYKFAEQIFNTIAGEQERNVYAVGDNPAADIKGANDYGWTSILVRTGVFTGKDNSPDYPAKMVCENVEEAVEKVIAKEEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVL2</accession>
    <name>A0A367IVL2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BST1_1</name>
        <name evidence="13" type="ORF">CU097_000022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01003324">
        <property type="protein sequence ID" value="RCH81692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVL2"/>
    <dbReference type="STRING" id="86630.A0A367IVL2"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="62"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="12">
        <location>
            <begin position="618"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH81692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="885" mass="99519" checksum="BDC0305BA01B9C8D" modified="2018-11-07" version="1">MSIGIILDSFLHHQRDVSGCRESYMRPQYIKQTEFDSEMTRFAGKYSLYLYREKGVDLTDQPTGVPVLFIPGHAGSFRQVRSLAAEAAYYYYTHYEKDTIKWQQGVRNLDFFTVDFNEEFSALHGQSILEQAEYLNDAISYILKLYTQARKTHASSSLPDPTSVIILGHSMGGIVARTMFTMYNYQHGTINTVITMSTPHMLPPAPFDWKISQLYDDIHRFWQEKVSSVLKDVAIVSIAGGTLDNTVCSDSTNIESIIPATHGFTVFSTAVPNVWTAADHVSILTCNQLVKAISKALLDITDIRRAPQTKPLEERMRTLRQAFLGSPEDRVGDLPLGNHSIFHSAETDVLSLSPGDRITIEHERIADIVLLPTVSNADAFAILTDDPTPGRFEILLCSALRSDGYIICRDINAIAIPVPASTEKDAHPFSGRTFSFASINFSDMKSFSHLGILDKGTTEIKSNFLIVEPLNTRMNSQVIHQSMLSIALGGVHVKTGSSLLTSIRIPSIESPILAYHLKVSRPNCQLSHFAPFLRQSISTMHESKFYVNLAGDNRDAAEVAIHGRTAFASIMNKPKSVDQDGLSFQIWMDPTCAEPLQLDLSIDWYGSAGRLGFRNGIMLATFSFIIVMLVFASQIQCYNNTGIYPSFGQGLSFCLHRSLPIVMLCVTICSIAQCSSTALLPSHLETMWPLDRISWQDILTGNTDPFFWWIPLIGLVVSVGVVNLLWLMVENLLKLVANLSICCSIHNLWPHPRSQETRYQRIQRRVATTVILFMLVATCIPYQFVFVVAFLVHIVGCVRSLIQCKMQMGDIRKANRYHFMFSLLLLLFILLPFNLPILLVWIRNISVHWFVPFSSDHSILAIAPIMIYTELLTSHRKMLPRQNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX85</accession>
    <name>A0A367IX85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_005178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003058">
        <property type="protein sequence ID" value="RCH82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX85"/>
    <dbReference type="STRING" id="86630.A0A367IX85"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="50997" checksum="F241B417C7D966D6" modified="2018-11-07" version="1" fragment="single">FLEGDYQLLFKLVFCVAKVAYIYSGGEQEYLAYEFPNPKKLVAFVFIILVGVFGRGSGLAQGSTVFGNNIIFAIGGPNYVNNWGSRGFGVFCLTFWLVLNITSAKLAIRANNFFTVLKIALLVLLICVGFAGFAGRLPNRPDLAENFSFHGTSNNPGSYATAIYYVIYAYGGWFNLNYVLDELKDPIKNLPKCAISALSLTTVLYILANIAYLAVLPAAVIKSSKLTVAANLFNTALGGVFGGRVLPVLVGMSSFGFVGVIFYSGSRIVLEAARTGFLPFDRFFSKLHPKLQTPIPALVLLYVIAMIFLLAPPPGTVFQFIVAFSGYGQYFFVGLSVVGLLILRRTQPDVKRPIKAPFVVSIIFILMCLYTLVFVFIPPDSPPSGYPYWLPYVVTIILALCSVGLWYYKLVYKDALATSYNAEIQKDGKQELFEDVYETYGSFKTTSSDTLDKVVVHEVSHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY50</accession>
    <name>A0A367IY50_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shq1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002952">
        <property type="protein sequence ID" value="RCH82623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY50"/>
    <dbReference type="STRING" id="86630.A0A367IY50"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shq1 C-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="26697" checksum="FCD8D921AC048079" modified="2018-11-07" version="1" fragment="single">RFDEDHYCTDFAEDEEIRQLMKYKTVYAKELKRMQKENDEAKVTFTSQEEEMMRQLPRKEYLVSNEKSVYLGLVDLLFAYSYNHRMTEGEGNVESAWCIGKLSSTLSCLEQFSTLKEVIITSFRRSLIYPLYRHFEFSEKIVQDVYILFKLGKRAILKALLEMKYIFDHHDVYYIYSKIYLDDYCVWIQHASDHVLRTLAHELHHLKINKNELGWDLDEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ58</accession>
    <name>A0A367IZ58_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002818">
        <property type="protein sequence ID" value="RCH82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ58"/>
    <dbReference type="STRING" id="86630.A0A367IZ58"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17919" checksum="A610FCB3F731A03F" modified="2018-11-07" version="1" fragment="single">SDSEPLFSYITYIARNLVQCSRERIYHQHTLLPSLSKFVKTIFKKCRLSPAVIVVGLIYLDRLKKNLPNGAKGEYDTPYKLFLAAMILATKYIEDHSGHAVHIYRVVSPIYTPRELNEMERSFLNILKFNLYVDSDQVDKFVKAHQDKLQLHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ73</accession>
    <name>A0A367IZ73_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL8</name>
        <name evidence="5" type="ORF">CU097_007718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002829">
        <property type="protein sequence ID" value="RCH82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ73"/>
    <dbReference type="STRING" id="86630.A0A367IZ73"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="67" mass="7446" checksum="12D733BABBE8DAB5" modified="2018-11-07" version="1" fragment="single">MGRVIRAQRKGAGSIFKSHTVGRKGAAKLRVFDFAERHGYIRGIVKEIVHDPGRGAPLAKVVFRDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ98</accession>
    <name>A0A367IZ98_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ELP5_1</name>
        <name evidence="10" type="ORF">CU097_003703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002811">
        <property type="protein sequence ID" value="RCH83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ98"/>
    <dbReference type="STRING" id="86630.A0A367IZ98"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="38092" checksum="8836CC7D567F9525" modified="2018-11-07" version="1">MNTLCLEQILKNKSSSFILINDTVRLSSLPILVNIGKRALGDNKSLVVLLTETSPKTWKKQFGETDDMYIIDCYTDPYGWDNTTDSDCSLLVNDITDIENSILLPLIKKVTKSAQCTILVDSLVPLFMISQFKTYQLVKTLETLTTDTTHLAIGHHSDIKLPTLSGISIQESINRLATVIIRLEALKERTHFDTQVALTGFTPQDTFSYLTTTSNALSKGGLAHIEWRKKSGKVTFETNGFIVKNGALQVVPASQLTGVSATEMKSEDMEIDKQPDPTANLSFNLSLTDEQRRAKESLVLPFMKAQQLEVEEQKKQESVIYYDPDAADDFDDEDPDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZX8</accession>
    <name>A0A367IZX8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002726">
        <property type="protein sequence ID" value="RCH83245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZX8"/>
    <dbReference type="STRING" id="86630.A0A367IZX8"/>
    <dbReference type="OrthoDB" id="10653061at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="15938" checksum="D96F552B97F47051" modified="2018-11-07" version="1">MSHDPRGAQGPTLRGPRRSTDSRRSIVEVEEELATTRSIHSARSANEARSLRRHSHFQHHPHHHKDVIAPLHDPAGKPLRRHGTETIGDVLLHPLKEMKLHHQRMEAYEKEKKEWNEKHPESIASDKDVEGMKEESIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0N8</accession>
    <name>A0A367J0N8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002642">
        <property type="protein sequence ID" value="RCH83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0N8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="74" mass="7909" checksum="628E24769F88143F" modified="2018-11-07" version="1" fragment="single">SLHNYNEPKKEESSKKPKPKLSRKRKTGNSEVPKGSHKRARPNASDLASTSAAQPTPAPPNQPSATAVQPAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1M3</accession>
    <name>A0A367J1M3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002607">
        <property type="protein sequence ID" value="RCH83611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1M3"/>
    <dbReference type="STRING" id="86630.A0A367J1M3"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="493"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="599" mass="68970" checksum="C726B18C47E2E1A6" modified="2018-11-07" version="1">MSAVAEEVETLKSKLKEYEKKEASWKEEHAQLLNFQKKLTQAGSHLKALTQENANLSKKVTEEKKQREELSKEINDLKTKLDNTKKGHQKEIKQLVDILETTIDEEHKNSPDVSTSTLLDSYIKSVQKRIPKKAANAPLSQTVQDDIETSLKNILKDPENGAIEDSSITPSLRLTLEQVRSDLHQLQNTVNSHQSNIDEVQKDLKRQITQLNITNNELSEEKEKLSSEKEELESQVESLERQLSDAKNNLTESENKRDSLYKEHQSLIGKLAHIKETLTPRLEQDKQLREKVSELTNQLDTANQQLEDCQAQLNIKEQEHLEEQERQQRAIRNLSQQVEELRTKCEEYESMTMEMDVQCSQVQEKLQKTQTELEALKIKLAKEQAERESEKTSLTNLQTVLEEFQATKDAEMQAAIEHVQKQLDVAKKSWKEYEQRALTAEAALEKYQQGVEKAERYEKEIKEKNLLIGKLRHEAIILNEHLVEAMRKLKEEASEDSVDRQLISNLLIGFLNTPRGDRKRYDILTIIANVLHLTEEEKEQIGLLRPKQSLGSPLPTAIEQPATESFTDAWISFLLKESSPLRRNRSAVTLSSTENHIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2Q6</accession>
    <name>A0A367J2Q6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NDK1_1</name>
        <name evidence="10" type="ORF">CU097_002038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002425">
        <property type="protein sequence ID" value="RCH84227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2Q6"/>
    <dbReference type="STRING" id="86630.A0A367J2Q6"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="227" mass="24456" checksum="385E69736EBB21FB" modified="2018-11-07" version="1">MFARAAARFAARPAASMRARTFATVNRAAVSSASRHGMTVCAAVTAGALSYAYFQSKEPVSADAKPIAGVKGTLTERTFIAIKPDGVQRGLVGKIISRFEERGYKLVGLKAIVPPRELAEKHYEDLSSRPFFKGLVDYMTSGTPVIAMVWEGKDVVKQGRAMIGATNPLESAPGTIRGQYAISVGRNIIHGSDSFESAEKEISLWFGKAGELVDWTPANAEWVQSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2S9</accession>
    <name>A0A367J2S9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_008260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002421">
        <property type="protein sequence ID" value="RCH84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2S9"/>
    <dbReference type="STRING" id="86630.A0A367J2S9"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="25440" checksum="8802B5B681BCEB07" modified="2018-11-07" version="1">MSDIYSLPYTNPIDSLILDPIIEPEAISENDLNLWTNAQFTYDIKPPTAQSSGGDKSPDSNSSSSSNSSPNNENMAYGYLAQVPPIQIDYAPMFRNITVSPENLSQTTHHQPLLPKVSLDDLAKVLLSPMTPDTTVTQKPNNKPSKVIDNKEKNAVDEDKRKRNTAASARFRIKKKQREQSMQETVKEMTEKSEALQNRVHELEQEIKWLRGLLIEKDSVSTLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2X2</accession>
    <name>A0A367J2X2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002437">
        <property type="protein sequence ID" value="RCH84189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2X2"/>
    <dbReference type="OrthoDB" id="10445475at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="259" mass="29072" checksum="3D41C4C030D06668" modified="2018-11-07" version="1">MAVWYKQLSSALYQDALLMSSLLSGNLGALRNPDKQTYSALKALLGHAYDNGFANPGFCKLLISDFIVHDLQTANLRLRTANKYPRFRQLCLETIALLLQGRVLLPIVFLPLCISGSASTSDLDAATIDLTSLCRLSTFRVSNTDFISVLSLTNLETEMIRACRASCIVDVYLGDYRFLQQREIRVISCYIERSLANNVYIPLFQVNARPGLIYSVIPLMKLHLIFSSVVLTKPYCGPWPFLSYFLGYPAHLLKLNNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3L6</accession>
    <name>A0A367J3L6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002341">
        <property type="protein sequence ID" value="RCH84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3L6"/>
    <dbReference type="STRING" id="86630.A0A367J3L6"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="34801" checksum="00D7B95ABEBD0B53" modified="2018-11-07" version="1" fragment="single">MLVKAFQEDYRLNFKNHQVDGPSSPRDYLEWNARVRKWRLEQQAKKNEYGQSTTGHDVPSLQWAQRSYAQHNVMLHDLFLFDPVTNTYTTDKLLKDIEERYGVVDSVVIWPSFPNLGCDSRNEEDYFRCLPGGTAAIKALVADLHHKNIKVIFPILGWDNGTRDPQAPWSYILPRLFKEFNVDGMAGEFSHFPQDFWMSSLAIGHPLVYVSQASSKHSLNQASEADDTFTLQWNTMDTAKYDTNSRIPTVSSRKLIESRHMTHASDKWCRNKTSLIQHAFFNGIGIEVWENIFGIWNQLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J579</accession>
    <name>A0A367J579_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRP18</name>
        <name evidence="10" type="ORF">CU097_007340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002188">
        <property type="protein sequence ID" value="RCH85083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J579"/>
    <dbReference type="STRING" id="86630.A0A367J579"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="356" mass="42190" checksum="9AC53F61B0804ADC" modified="2018-11-07" version="1">MDFLKSAIQEEISKKRKLLEAAEKKEGENKKQKYVSRAELERIREEEYKKKEEERIKREQEKKARLEEEEAKRKELERQQSRANERESQEKSEEEVETFNISMEECRRRLRAMGQPIRLFAETDKQCKLRLRALELMVEQQPENQGRNEFMKTLEEMEAHMRLDDLKQKGAVLTENKKKQKRQTLVVEPIQLELLSSNVDKLYSQIYAYFSHMLEEWEEYMAARPEEEKRSVPGKRAAVLQKQATEYIKPLMRHLKKGTLELDVLARVAEIAQRMQKRLYRDAQDAYLQLSIGNAPWPIGVTMVGIHERSAREKISSSQVAHVLNDETSRKWIQSVKRLMTFAQTKYPPYTLSQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5C8</accession>
    <name>A0A367J5C8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002196">
        <property type="protein sequence ID" value="RCH85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5C8"/>
    <dbReference type="STRING" id="86630.A0A367J5C8"/>
    <dbReference type="OrthoDB" id="2435184at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122336" checksum="A2F06A9EF0203222" modified="2018-11-07" version="1">MPPDIAPISSNINPVSPKGISTVRKENSLYRSFDSVNETAQLTYSIHRTGTTDHSVFCCIPHRLKNLKVPFSIAFSEKFPFGVGLGFTTHEDVQGTVVEATFISAEHCKEAVATPLVVENHVFTASPAIHPDRALLKVNLTKIPIMSIEQLRDKLLNNFARYGIVRELVIYLDDWAQRWFSGNGCIYLERPPSSEIKFDPLTYNIPFDGDHSCLGTWSKMDKHCIYCKAMGHIRKDCPSLPTETRTCFVCNSRGHIARNCPKVTNPNQTASKRRRPIPLDSSYEATVTVLSRPVETLSSTVPPTSSAPVLHEIPATSEEVASAPAPKHHTAAPMPNAATQPILDHTTSTEILSDVTMDDSENESMVSSTPSIKKSVAKIAKNKTSIHPTRKSSRLNKGQTGEKFHNSQHSTLGISAAASTLLGHGVENDTDTSSPLLIMNNLMNNNNNSNFGDLLASQSTNNNNHNKLTTLNIGSLNCRGLRKTTNPATSAAFIRYLRTVSLDILALQETHADTDEIAHLFKTQFQVNTSYWSNYSGIICFSPFLSLSEPIWNTIQRTPTVKVSHVHEAFDPVFVTAVYAPADTARRLSYLQSSLLNPYKINAYATDEDLEDDDIDVDTLATDLDNEDLTPEDFISERNEALPIIKPNLKLDMPSTTQSIDKPTKKLRTYNEAITYACQQKGTENDKNKTMFIVDTLSLKPFAILDNHGNEENALAHDTIVNKLVTKHDSIKSIPTMKRPYKDDSATNSLCINCSSQVHAELSNLFDTSPYSSLLKQREYTPLTDDICTLLNKDWQFYPQVKYFSATVFAGSIILNTNNNQAIMINTVEMYGRTKITDYHRESFGKLKNSVIKNSLPPPIKIFHQNVWPTSLDVRDGKKLVIGTQVSNALVTSSIRLDEKGLVSIGATSSHFMLDTIKDSLASKIFIDLNSLKSAKALIEDPSTTHVSDIGIVFHQLRQVRTKFHLPSTYSLCRASGPITINHTCHPFSLFTLSEFDRGRSPSASIFRTIANEVLSNNSDAKLAKEDVSRWINESKGKRKAILSNILDLYESDKDWLPILYNAPLNKELEALAILLIPTIVEANKSVEAQVKQVFEVFGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7Y0</accession>
    <name>A0A367J7Y0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_007158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 14">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001952">
        <property type="protein sequence ID" value="RCH86047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7Y0"/>
    <dbReference type="STRING" id="86630.A0A367J7Y0"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000002">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009169">
        <property type="entry name" value="Calreticulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF2">
        <property type="entry name" value="CALRETICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002356">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016487102" description="Calreticulin" evidence="14">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="346"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="346"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH86047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="416" mass="47122" checksum="4693C072F652B073" modified="2018-11-07" version="1">MKIPTITAILGLAALASAEVFFHETFSDGEGWKDRWTPSTYREDLGKLEVSPGKWYVDEKANAGLRTTEDYRFYAISSKTKPFTNKDKNLVIQFDVKNEQDIDCGGSYLKFFGGEFDPKTFNGDTSYNIMFGPDICGPKSIVHAIFSYNGTNYDFKKTISAPKDTLTHTYTLIVKPDQTYEILVDSDKKASGSLLEDWDFLPPKQIKDPNAVKPADWVDDALIDDPNDVKPEGYDDIPEFIPDPNAKKPEDWDDDMDGEWEAPSIANPDYKGPWTPKKIPNPAYKGEWEHPLIDNPDYKVDNEIYAYDFANVGIDVWQVKSGTIFDNILITDDIEEAEKVRNETKVLHEKEEDAKKAYEEKVDAENKAKAEEAEKDAKKDQEPETPKEEEILEALEDAVEEAVEADAAKKPARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J829</accession>
    <name>A0A367J829_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001947">
        <property type="protein sequence ID" value="RCH86070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J829"/>
    <dbReference type="STRING" id="86630.A0A367J829"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="69"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH86070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="30923" checksum="C21070F9C17B4E0F" modified="2018-11-07" version="1">MATHPHQESQHPHHHELQHPQPLAHAYQPAPTASGAAGHPQAPVATAGQPVFDLAKFWQEEMANAERFDSDFKNHALPLARIKKVMKTDQEVKMISAEAPILFAKGCEIFITELTKRAWVHAEENKRRTLQRSDIATAISKTDMCDFLIDIVPREEAAKSTAVYEHQNAYANNTAYYPHQYAVDPATYYSQLPQFTSDQVQQYQMQLQQFAQQHQHLPHQQDPSQQAQAQQQPQPQQPYQGQPQQQAQPQQQAHQDQHMNPNEPKLKNDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J896</accession>
    <name>A0A367J896_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001972">
        <property type="protein sequence ID" value="RCH85961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J896"/>
    <dbReference type="OrthoDB" id="2282120at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="71" mass="7731" checksum="7029B0C2B509D7BF" modified="2018-11-07" version="1" fragment="single">NIRLIWDTNLLTTSTALPNNILIRPDIVFSTVLPSGKEAEIDNGEIKKPNVPENIVNETRFAANGGLQCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9C9</accession>
    <name>A0A367J9C9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001852">
        <property type="protein sequence ID" value="RCH86505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9C9"/>
    <dbReference type="OrthoDB" id="10273511at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016784758" evidence="1">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="204" mass="23198" checksum="4E6ABE73F6CC3D8A" modified="2018-11-07" version="1">MTSIFLLFVLITSCLAAYPEYNTCYALTAWSEAGEGTIGWGKRRRWDTYRLMLKKELPSVHGATKLTNAQGKSGKVFPWDAVHVETKFFGTEKMYSWGRQQSYVNPAPQTESEVFVLKPSHLEDHWLIRRKQDGLLITFQPDTMSSAYSPDRAALFSFEPIDDAYCSDKAYLPDPSKFALYYQQIGSGHSVKRGRNDADVKTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9L5</accession>
    <name>A0A367J9L5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_007478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001822">
        <property type="protein sequence ID" value="RCH86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9L5"/>
    <dbReference type="STRING" id="86630.A0A367J9L5"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLM1/RGC1-like BAR-like" evidence="4">
        <location>
            <begin position="166"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="SLM1/RGC1-like PH" evidence="3">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="69809" checksum="9DA3AD7F52599147" modified="2018-11-07" version="1">METVTQSNGVRTTTNVQKDLPEQNNGIMTPPMSPVKGSMDSHRHSANVEVGQTGLPWLARDAEGDHFHPHQQQESPPPKLSAKPASIVRIPTRKRTIQRHAYRMKDGLDPVKVLCDRIKTWQVSVKYLMNLFSRVKNVEATTGRGYRRIDAKFMIPSKIQDQFKSSNGVQDAWMAFRQFARENSLIHQDFVDFIENEMIPTLSLMLKDMHHFMQSLLYDKNLRTASLYDCRKKADKMLTRLNTEIYNLASNREDSIKSGKGPYLIPKKDPLLTKYAVMNTITDLYKHENHLHKNFLEVQDKYRQFEQAKIINVYTSLFQRFEAYRSEHGLERSEGVSKIVNIFNAIETDSEWYEFLHHHDNELVKPSAAFKDEHALEFPNESHPLVQPLIMGDIKRKVGSSKWHNEYYILSPVGVLYCFNSEKDFYRRPYQYKFSIFVPKSNLLVNPASQLVEFTGKSLGLFGKKKVLHMTTTNPQDITHWVNVMGPIANYQQLVPSSQNPAANTNINNHQVDTTTPIVNNNASSIQSKKEEGESSIDTIQKDQNEQSAGFDGQSPILSKGHLVEEHEPIAEQSDVPASNSNMDAVTDENHTKEQAPLKQQSDILNDTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAF3</accession>
    <name>A0A367JAF3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001771">
        <property type="protein sequence ID" value="RCH86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAF3"/>
    <dbReference type="OrthoDB" id="2407359at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="189" mass="21499" checksum="665950098870058F" modified="2018-11-07" version="1">MTLIYGYEMDSIPGQVGHVISPPLLSTKITLSSAGNTTRWIFFGRRQEIVDWIREHPDIILENTLFVGENSGHTHTEIVIDLQQVNDSEQSYYDYIKSFFVSIYDVERVKVEIRPRVESKDNMITCLNRVIVANGTRLGDIVDDLQTEWFKPAESYVQQAVHLLNDEPTPSHVLSAKPPSSIQVTNEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBH8</accession>
    <name>A0A367JBH8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COG4_1</name>
        <name evidence="11" type="ORF">CU097_007685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001683">
        <property type="protein sequence ID" value="RCH87312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBH8"/>
    <dbReference type="STRING" id="86630.A0A367JBH8"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="179"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="781" mass="89906" checksum="439972E9EA1DC129" modified="2018-11-07" version="1">MPTATLPNQSLMQTNILDKDFDSLINIDEIRESLRQLDEEENRIDAFLDDTLKQESILDTSLNSLKSIKPQLDTLKVKAATFTDTVSQTAHLAEVISDKVRQLDKEQTRAKLAIKYVEDVQELKFCISSLNEAMQKKEYDRAALLLQRASKIDSSILKGSLAEFTVPTSEYPDHPERTLAETKAALFDIFSRRFDDAVAERNQADITRYFKLFPLINCQTEGLDQYSRFVCNIIKSRCADEMSEGLVTAPTYFADALTRLFENIAVIIDQHQPLVEMHYGKGKMLRVIQRLQEESDKQGVAILDRFLQTRKLETKLVEIQCLMIAMLRSGSTVPSRASPNPSTSASTQNNDVNNPLVDPRQLDANLYELSLISQRTVLFNSFMSERASDEMDVLASDEKELVMKGKDSRFYGPNGLLASSGLSKRVHEMMNSYLVIDEYLLKKSITKAIHLDDYDPATPHASSTCVDDVFFILKTILKRCISTYKPDVISSTVRTLLKALENQYIHYFQQHMSTVFTAHDTTGRNAEKVIENAKISYMVVLNNLDISADYTHRLAKELQPEITRAIWLDEENDVARVTTSIDKFEGIADKFNQLLKHGVEQLVNQVLKPRIRPLFQESYREVKYVLEEDEYNEADIEEKFVKRFRQGFNHLIHLYKRTLTENNFNTLMDLMLDIITAQWERIVSQTRFNQYGALRFDKDLRSIILYLSSITEWLSRDKFTRLNQMSTILNFEEPSEIHELWGNSSSPINWRLTVNEVKKILGLRLDFESKLADEQFLLNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD73</accession>
    <name>A0A367JD73_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phospholipase D</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPO14_4</name>
        <name evidence="13" type="ORF">CU097_008716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001574">
        <property type="protein sequence ID" value="RCH87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD73"/>
    <dbReference type="STRING" id="86630.A0A367JD73"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="222"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1028" mass="119855" checksum="2AFB54F423D934DC" modified="2018-11-07" version="1" fragment="single">MSNPIADTADYFNRYNKQQQYQQQFEELPRHIPERPWTRVLDRISFLIPPAYFHGDDDSVYNDRDTFELMKSKASSEDTTLDEAYSSSTAKSIIDIKPGEEEERLPSAADLSKAMTPEKETSDYFTHPFPEQQHQHQQENRRDISDYYRTVAPPEEGRIKDKWDRTIDKLKFIANLTSHQPVVVQPILGPSHTLATYYPPAFDPVFTAFARDEYGRKLPPILLQCIYATVTDSEYVDGINQWVFRVELQYGDVKWVIRRNIADFMALHFKLKVKSNLYDYVPDPPNFPNQLSNLLDTAKSTIGLFESKQTNYNRRATLTNYLRSLLLRAHVTASYDICEFLELSAISIAHDMGWKGKEGYLKNRIRHVAPKCFCISRITKRWTTEWIILRDSYMAFSKDAASSEPTDVLLFDSSLRFEVLEPRVYLGNYHIKIRNQSREIEIKGTKREIDQWIDSIEKVKSESPWVYHHRFASFAPIRHNAKVKWFVDAENHFNAVAEAILSAKVEIYIADWWLSPELYLRRPPEENEDFRLDRLLKRKAIEGVKIYVVVYKEMSLALTIDSVHTKQTLQNLHPNIIVQRHPDHSLGKNDTVLFWSHHEKIVVVDNRLAFIGGLDLCFGRYDTHAHSLSDFPAEGHDREVFPGQDYSNPRVKDFINVAQYDRTLVNRATTPRMPWHDVTLGVVGPIARDISRHFIQRWNFLKTTKSMHRRAVPFLMPKGEYVAARDESKFSGTCKVQLLRSSSRWSSDIEREHSIYNAYMECITHAKHFIYIENQFFISTTTEDKLLRNKIAEALVSRIKRAHDKGEKFRVFIIMPLIPAFEGDLASSEAYSARNVMHFQYTTISRGGHSIMEKLRQYGIDPDQYINWFSLRNYAKLKVPPRAENPFDDLNRVPTNQTSSSPPRRKSYPTMDDRYSYVTEILYIHSKLMIVDDRIVLMGSANINDRSQLGNRDSEVAMLVEDTEMVQSYMNGKEYQAAKFAHTLRMQLWKEHLGLLNFERWSDLLKGTVEREVNELGISRHLTIYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD89</accession>
    <name>A0A367JD89_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-lactamase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LACTB2</name>
        <name evidence="12" type="ORF">CU097_009520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001583">
        <property type="protein sequence ID" value="RCH87829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD89"/>
    <dbReference type="STRING" id="86630.A0A367JD89"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH87829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="619" mass="71447" checksum="3783982E0260DC13" modified="2018-11-07" version="1">MSLWESQPRTDLPFLPHFSQLSDRVWRVMGLNPGRFTLQGTNTYLVGLGPRKVLIDCGDGHPEYMPLLIESLSKIDKEAYISDILISHCHKDHWGGLNEIMSSVLNKEDTIKVHKFPLLAENPLFKYLEPFPESVVFNELQDDQVIRVDDATHLVVLHTPGHAMDHCSFYLKEEHAMFTADCILGHGTVAFEDLSEYIRSLYRIQHYRPTRLYPGHGQHVENGTEKVEEYISIRLAKERQIIDLMKDGSATPIELVERMNVTFKNYSENMMAIIVRTVGLHLIKLHRDGKAEMINKERFEEKTGLDPYDPHNVFSIVNQKWQLCNHNNSTKRFLIEQKQQLSTSRSTTSLPDLVQPSKENQQMPDLSMRRGSSQLNIKSLTTTTTTTSTREQLHKQILKKRRHSFSSFLSVKYGKLAAADKVRSLKKLAALSLTSDVSRTLSSTEQGVKKGTQGHRPRSYSEIPYNIPHVERAPPVAITNKTPAYEYYGFAMYLASFVVFGVYLIWAYVPDSILHSLGITYYPNRYWALAIPVWLMTFVWFIFFSYMTINLWNTPSFDSFDCITDEHANIMKLENQKSIDQPSDWIPELHDIPIGLVNKFLYYEHTEAKKNANKRVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDM3</accession>
    <name>A0A367JDM3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001544">
        <property type="protein sequence ID" value="RCH88020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDM3"/>
    <dbReference type="OrthoDB" id="2366000at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9480" checksum="6C63AB96DF0DCD73" modified="2018-11-07" version="1">MSHCSFSEKETVYEVTLDANGVAQRVPKGQGTHFIHISPHKETLLKEKSDITAPSPTYHHDKWPSMTAPIYNQRVHPMPEKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEV2</accession>
    <name>A0A367JEV2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_011081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001461">
        <property type="protein sequence ID" value="RCH88473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEV2"/>
    <dbReference type="STRING" id="86630.A0A367JEV2"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="25823" checksum="4BDAC248DFD67B04" modified="2018-11-07" version="1">MSISSIIASSSNPYYKDEKRISLPGHPYNHPHHFPLFRSPPASPEPSSPSSLSSSPRHSMCSMQQKSTDDEEDREASSAPLTLEERRLRNKAASAKYRQKKSQQHSEMKYMISKLSEQNAVLERQLQELRLENERLKATSDRLRGKMVARKMLKKWIGKQASASDNMVCSYNQQQQQHYQQYGDRLSYLCHLPSNSPLTTELSSNMIDISNSEQEDDVDDVDLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFC8</accession>
    <name>A0A367JFC8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001431">
        <property type="protein sequence ID" value="RCH88636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFC8"/>
    <dbReference type="STRING" id="86630.A0A367JFC8"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH88636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="509" mass="55580" checksum="B87615B5DE5EB3B9" modified="2018-11-07" version="1">MSEMDSTHIKFPPYMLYCVLVSCLGAFSNGWVIGSPNVPGEVTHHCINGSDYAYSRFFPDCLPMDDALWGFAVASFCVGGLIGGLSGGTIQTRLGRKKTIILNNLGFIIGGILISCAISPFMFIIGRILCGISCGIGSLTIPIYIGEIATIPTRGAMGTCNQFFIVIGILLSTIVGLFLANVPLWRLSYVIVAIPAIIQFFLMNTCVESPRYLISVNRIKEAKQALQKLRSNASIDVEFYNMLEGHFGTATAQSMIQELDLTIEKIEYNSVEVADGTTPAKLVDTQTTIVASQPPEAMNIVQIFMDPVIRRISLTIVCLHAFQQLVGINAVMYYSTKIFTLAFDQEVSKYMTIIATVVNFVITIAAVVLVDRMGRRPLLLAANAGACIFCTLLVIGYVYTIPSLLVVSVFLYVASFAIGIGPIPWMMTSELTPTYASSSVGSMGTCVNWSVNFLIGQCFPVIFAHIAGYSFVVFAVFAALSFLFTLFFLPETKGKSLEDIVKSYEKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFR4</accession>
    <name>A0A367JFR4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001406">
        <property type="protein sequence ID" value="RCH88793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFR4"/>
    <dbReference type="OrthoDB" id="2206777at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="300" mass="33955" checksum="5998054AC3C349BF" modified="2018-11-07" version="1">MNNLKHLNIRTITSGMIGAGPLLSETCIKYIDTVIDSKTLDDFKKNIRKALAYDDEEEATFDFLEAVLKAIYLAKQDLYDGEATFNSLLIYPFLNAVCIFVADSVAETFLKSMIKQLKNSYTISDSCQYKVDGILKVYLDKEIEVALLETSSHFLSKDKAKCSFDHHKSIIGTLVMIKNIVYEYCFAITEAFSKLKVLFIHAADDKALLWSIRFSVFIPVCITFYLYTKEESRKSSSCVLQLKSEHEEALKKCRFRATKPSRTLKSVVKPSILKLTEEEGNMGMADLGPFYSNPTSPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGG9</accession>
    <name>A0A367JGG9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001402">
        <property type="protein sequence ID" value="RCH88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGG9"/>
    <dbReference type="OrthoDB" id="2226511at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9409" checksum="0551AD5806511602" modified="2018-11-07" version="1">MKFGIDQSFMVIFLTTYLQSNHTTSPRVIKSMKRLGLVEEDEHDVRLDFIFTNIAVAGLGDALFCEDQPTDKVSKKDETKPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGX4</accession>
    <name>A0A367JGX4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001333">
        <property type="protein sequence ID" value="RCH89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGX4"/>
    <dbReference type="STRING" id="86630.A0A367JGX4"/>
    <dbReference type="OrthoDB" id="2381286at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="303" mass="34674" checksum="0EAC47F4EA1B5AC9" modified="2018-11-07" version="1">MSAKPRHAQLIQEEHHLRRQSAPLFSTQLNRKPLPQEPIHQQQQQQQEPLPPVEYNPVDTDSSIYMNPVQQHPVGFIQHHPTYPLLYSQEIHPYPQPPQTAADAYPAMASSMYPNYPPMHPPIEYHSDLSQHEYPQYIQPTPMMAPNMTPSIMTTPALAPHQRIIPQTLSDPPVDNKSEKKDTSAKNEKKTRQITVQSINKEHRVWIDVSPTETGLSLAEKIHIIATFRTRKIVSITTASGRKVPLDNRPVFGSWVDMENFQDGERWTVEWCENDRGVVDRLISKVVQAGGGKRHKDHIAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGX9</accession>
    <name>A0A367JGX9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001341">
        <property type="protein sequence ID" value="RCH89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGX9"/>
    <dbReference type="OrthoDB" id="2279623at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11629" checksum="703015A676A425E6" modified="2018-11-07" version="1">MTNNREDNSTSTSESTIPYYGSKVPRQSASEVDNIIFNMMDDIKNAAFEEKEETKEAKNDNNEDRKLNRIYWNIRILLISVVILLFVVGTVLLSELTKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGZ5</accession>
    <name>A0A367JGZ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001337">
        <property type="protein sequence ID" value="RCH89166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGZ5"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25946" checksum="A64661035BD53296" modified="2018-11-07" version="1">MNNTKALMIGSIPIGLLIITHLKSLPFAYTVRSWLLLRTLIKRAKANNLQPDDLFTVVSQSHRCYLDDIDYNQHMNNSMYNKLLDFSRIHILYTVMPKVMMEPNHHIFAHNAGVLTLFKKEIPPFSKFNIESRIYTWNDKWVFLQHRFVFDDGSVACYALSKIVFKKLSGKTVLPKQVFELCGHDLESSEIEERRAHNWKIAQNMLNLDQLVQDTYSWSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHC4</accession>
    <name>A0A367JHC4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001306">
        <property type="protein sequence ID" value="RCH89340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHC4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="293" mass="31909" checksum="74F3B3F4EDB89E21" modified="2018-11-07" version="1" fragment="single">MAYAKKFHQIKFQLQNQTGANNSAAATSMMNDNQLLNINPLAGQQMSPLLQQQQPQSQSVSPQVQPARTAAQAMAAAAAGTNPSNNNNNIINNVANMNTTAQQQIPVNMLQQLNMANANQAAMTMSPRQFQAYLTRQIALQQQQQQQSGQNTPQMTSQQQQGTPQFSNANIDPASIISLNMAQNFRTPASGINTTTTPMQPNNFQNTQAKPPQQPSQPVQQTQQPPVAPNVQLNAGTTANPINNAATAHPSLQQRTQAAEYVRQMDEGVRNTRVRANPIENMSEQEKAAIRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHF4</accession>
    <name>A0A367JHF4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FRR4_1</name>
        <name evidence="13" type="ORF">CU097_007855</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001309">
        <property type="protein sequence ID" value="RCH89326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHF4"/>
    <dbReference type="STRING" id="86630.A0A367JHF4"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00503">
        <property type="entry name" value="Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH89326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="177" mass="20751" checksum="D4926812B1B78E8F" modified="2018-11-07" version="1">MFKHLTRQTLQQAKRLSPQIALRPPSARIYARAIPRFIHNTSISFDNNTRPTFTPTTLNTDRYHRLSDEILEHIVAKLEEIGDEIDMKGFDVEYSQGVMTLSVGEHGTYVINKQPPNHQIWLSSPVSGPQRFDYDEQHRKWFYARYNQTLDEVLNNELSKALDRKVDLLEHFDPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIP3</accession>
    <name>A0A367JIP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coth-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001223">
        <property type="protein sequence ID" value="RCH89814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIP3"/>
    <dbReference type="STRING" id="86630.A0A367JIP3"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925269" description="Coth-domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66220" checksum="C63A109B952096AD" modified="2018-11-07" version="1">MVYLKNIIFLFGALTFVCAQKGAADKHIKYNVIGLLSSSQSMGVIVDNVTYALELNSSSTILYTGSAPVARQGYRYTKIKKLDNSTINEPFLRSPVETDTVNEFFNRTWNKKQIAPLPTVYKPLPFIHRISSKLHQEGEIPTIHIIANETEVALLHRNASQDIEIKTNLSYVSLNDSLSFQNVGLSIAGASSRMMPKSSYNLKLHKKDRIYGYRRIKLRAMATDSSYMREKLGYGMVKSLGLISTDFSYCRVFLNDQEIGLFGLIETFQDPWTANVFADGDKDYKSGNLYQGVGAGTNNTGGLNYLSNLTAYGDGQYKIKAGNKEDYAPLQELTKFIADAPVNGTDAVDAWKSKIDMDSVIRSMVLEILNAYFDGYIYNSNNYYIYPDPSSKKYIYIPSDLDLTFGTSFGPVAPLISGNYSTFTHMYDRPLTNKMLQVPEFKQQFEDMLINVTKQLMNPTATNDHINSLADMLQEDVAWDAVVPRMVLWYNTEMSKMFNVSNGRIPPDFDMAPALRQISKYGGNGLFGNNMAASAVSQDFNKTLDFSTIVTKGLPFREAVNGPTGNSASMGVKEFINTVSQNTLKFFNHSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIP5</accession>
    <name>A0A367JIP5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001226">
        <property type="protein sequence ID" value="RCH89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIP5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="12391" checksum="1999F0A0D060AEFB" modified="2018-11-07" version="1">MANEFDKTRKPYATCAYNFSLRNRDSDTRLDKKIQCIFHNIDNENEDYLSVHTLGTVSSFSDNRKFIAVDDYEFETERNSEEGLSAYSQFSSIQSCFKNFSTTCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIR2</accession>
    <name>A0A367JIR2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001222">
        <property type="protein sequence ID" value="RCH89823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIR2"/>
    <dbReference type="STRING" id="86630.A0A367JIR2"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF19">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH89823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="24644" checksum="76E6008C21D6C996" modified="2018-11-07" version="1">MQNQLISSHVLPTPSPPPEPETDFKNEKITLKRKSWIKIVQRLLKELDGRDKMMKTIQYFIKILLHYKLIRAKHWSTMASQFSMTRKILRLGTAVGPFQEIEPKLNYRTAILLNEIINGVSDDIFCFHKLGFVSTSIGTRAEIISAYCWFIGILNDIKDQVQSLKKLQRNNGDKDKIFLAEISIIKLLMDAVFCGKYIILFKKFWDTDSIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJF8</accession>
    <name>A0A367JJF8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Insulinase (Peptidase M16)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IDE1_3</name>
        <name evidence="4" type="ORF">CU097_008331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001181">
        <property type="protein sequence ID" value="RCH90073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJF8"/>
    <dbReference type="STRING" id="86630.A0A367JJF8"/>
    <dbReference type="OrthoDB" id="2433092at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="2">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="3">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="493" mass="56808" checksum="0F13205539D4D406" modified="2018-11-07" version="1">MLDRLYIGLLSDSLTEYSYNAELAGLNYYIAQETEGIMLFVGGYSHKLSLLLERVVSKMKDLCIEQCRFKMVKDEITREYENVLLEAPYQHASYYLSFALSNRKWTYNDLITQVRDIQLEELQAFIPLAISTLHIEALVHGSMEKEAVLGMFSKIQDILTPRPLLPSQWAGSRAVALSDGQHFVYTLPVYDNNEVNSAIAYYSQVCRVTETGLRNRLFLIAQIAEEPCFNQLRTREQLGYIVFSGIKNVHGTLGFRVIIQSEREPVYLENRVLDFLEELKKIIQEMSEADYQAQVDSLIAEKQEKFKNLFEEGYRYWSNIMSAYYEFNESTTDVLELKKITKDSLLAFYNNYIYPTSSMARTISIHLKSQKVPVEEKPSLTAENVYSVLTALNYLDKKDISEDTFRDWVISYAGDAAQFKTELEFSQFLESKKIGTGQVKTILEKIYQGPSGLSQRDHSRLPDKYEVIADLIDFRRRMPLSPAAVSVLNSVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJH0</accession>
    <name>A0A367JJH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001180">
        <property type="protein sequence ID" value="RCH90077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JJH0"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="32"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1734" mass="198195" checksum="8D3EF9A8CCC66510" modified="2018-11-07" version="1">MTTKFENRLEALRSNVMDSGGVEEKVEVNQRHLIDKILARYSAEYVLYRELMQNADDASSSAVQICFYTGSSDSNKSINLSTKCNKIVFKNNGMHFRQEDWIRLKRIAEGNPDEQKIGAFGVGFYSLFSVCENPFVFSGSQCMAFYFKGDQLFAKRADVPEKDIDSWTSFLMDLREPMEMPDFDNFCKFLTTSMGFTANLREVTVFFDDQQIFSIKKRVAEPRAMAIDTRQMILNTPQRMFTITGADTRQIQLDSEKYTPPNILLQPLAGLLGMRKENGNTLPVEKGSIFLRVVTASLQVHVSRDYEKEMERATKKKPPKTTKFQLVYTGREELDASENNLDIYKNLIPFPNQGCVFIGFPTHQTTGCCCHMASRFIPTVERESIDFADRYISIWNKELLAVGGLLARLVYNDEMEQIARLYRELVGSQQQVDKTIVEGTDSAKNMLERRAAHALRSFTFQHSTPSSIVGKVHESWFFQSCKVPLNIMTSHGIQPITIARTVPDTMSLTGHNITQLLDKFIKTIPTITSIVYEECKDGMKKLTDHGLLQPLGLNDVLKELDSRSLTVDEMIACMKWWIECNVGNTAIPATTRNNINETTRAQFLGAAVMDCGEQKGLLQLSRAKYWQNPKIIPLDMDVPSDVMPFSVSKHFNANDLASYFGDMKELSIVYWVQYISQSKPELQTSSSFSERVLGIISKSFGNIPSKSEGEIVQLLKLKTCIPTKFGMKLPGDAYFPNVNLFDDLPTIQFSNTRSVSDTFLTSLGVRKHVELQMVFDRLLSEGSWSHVDLVKYLTSVQSTLTDVEVRRLRGTTIFTKEGEEPRIKVVTKPRPKATESDPTVLEKHEKKIYKRYKAADLYSPTEIAKNLGLPVIFWTPRWRPSSDEAKFLVDKLGLNTSPPLQTLLTLAAPAETMTEERKRIQKTALSYFIEHYKDYQEKYDASTIDIKFLPCSDGKTYSAPRDCFTNLDVQLLGFQTLHSDLVPMRDKLGVRENPPAPRLVEAFLSNIEKDHDKAKRIFEYMASRSGELSRTHWQLLRETAFIPVVSNGVTILKEPCHCYFESDDSTSFHKELFLFVNFGTLGNSFLRSCGVKDEPNTVELASMIVKDPQRFWDLSSGGERYLGALRQIAGQFYLIRSNRQLLHEMKTKPFLVGIKKMTLSEEQQQEQSNEENILDGEFVQYRLAKASDIFIIDDTMGHQIFSPLSAPMEPLLEDFYKQLGSQLLSTQIKETYSYTNRMGVTERTKQITEMIFERTPIIIYQMMNDNPQRRKELLHDEQYVRQHLKVIQAQELKINRVFKHTSEKNVQPTTACADRVDFGIYVSTASEMDYYDVANALCVLLFARVQFNDAIIVERYLTASLHHLRRKGVPVDRILNIRKQQIASPVRPITSNTNPVSMPRPLAPQELDKYTKQVQEVFGDCQEGYIRQLLSQQHDNHVQNVVNRLLHETYPKKTHQVKKVSTEEDREKQKQAISKAPEQKPTGLINRLWSWRQQQAPSTPSTTTSAESSSIVNNDNNETHEPKQPKLPPSETTITPNYTDNIRQNLKRAIHSCRPYTGQGVFTPPRINQVNESRQYCDATPGHNLTYVGNVMGMEFYVHRTIQGDDVLEQYGQAMAKFTSILNDLSKVFGLQLATIQIFYDKEGPTIAFNLSGSLFMNLRYYLALHESQTEDEAVKRKEALIYWFMTICHELAHNFVADHSSEHEFYMSSFAENYLESLMNHIYHASLPPPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJH5</accession>
    <name>A0A367JJH5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001176">
        <property type="protein sequence ID" value="RCH90104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJH5"/>
    <dbReference type="STRING" id="86630.A0A367JJH5"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="239"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="330" mass="37247" checksum="55DD606DDDABA6D0" modified="2018-11-07" version="1" fragment="single">ARVQVPDSRFDWLVNLYQPKKITPAHLTVVDIAGLVKGASQGAGLGNAFLSNVSSVDAIYHLVRAFDNENITHVEDTVNPVRDLEIIQNELRIKDEETLERQIMELTRQASREPTKKTMIGLSKRDELNIIEKVAEFMTKGRDVRKGEWTVPEVNVINTLHLLTAKPMIYLCNVSEEEYIANEGYKWLPEIKNWVEHNNPGDLIIPLSVPLEAKIGTMSNPSVESQLPKVILAGYKALDLIHYFTCGPQEVRAWTVRNNSRAPQAAGVIHTDFERGFISADIMKIDDLQHYGSENAVKAAGKYLQKGKDYIMEDGDIAYFKFNVTNNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJV6</accession>
    <name>A0A367JJV6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_003922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001154">
        <property type="protein sequence ID" value="RCH90234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJV6"/>
    <dbReference type="STRING" id="86630.A0A367JJV6"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016777228" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="135"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH90234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="24523" checksum="82593ADCF8C5489D" modified="2018-11-07" version="1">MRFTHSSLFTLTSIVTSSIVYQVSSAPVSPSDLASPESPSVALNTLSGMALAGQGDSNRPIWAKNIEKRSKHHKKHSKTHKKHHKKTTKKSKKSSSHKKKTTKRKTSKKTTKKHKTTKKSGSGSKGGQSFSGDGTYYTPSLGSCGQTNTEKDLVAALNAPQMNNPANPNLNPICGKYINVHGPKGSVRVKIVDTCPPCKVGDVDLSPAAFGKIGNFVDGRIPISWTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKQ0</accession>
    <name>A0A367JKQ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001109">
        <property type="protein sequence ID" value="RCH90517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKQ0"/>
    <dbReference type="STRING" id="86630.A0A367JKQ0"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_uL4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="267" mass="29736" checksum="4BD648435DBE9B11" modified="2018-11-07" version="1">MSLFNTFSRATARALPIIQNRAFASVAETTAPKGMFMNNACSYESTNSFKSTALSTPLQAFLREFKTNEPISIIDLEKDVFGAPIRRDILHRVVVWQRDAMRQGTHSTKTRGEVTGTGKKAAPQKGRGKARVGDRKAPQFRSGGIAFGPKPRDHSTDLPRKVQDLGLRVALSAKYAQDQLIVVDSLQHVESHKTRDLAQILQNAYDGSKMLIVTDDCNENLELAARNLPNCEVIHVEETNVLDLLTYDKLLIEKSAVKLLEDYLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL55</accession>
    <name>A0A367JL55_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001089">
        <property type="protein sequence ID" value="RCH90646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL55"/>
    <dbReference type="OrthoDB" id="2289409at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="125" mass="14399" checksum="666DB4ADDFD861DB" modified="2018-11-07" version="1" fragment="single">MTRDVYMEDLSLEDSSISEEQTSMIYTREDNDCEQFVKENDEKVKLEKFAENPTSNTSKTNSKKSAMPYKTYTTSQIVDFIGLIVDQAQIKDTAAKTGITLSTAYRYQKMWNETQEVPGEKKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMW0</accession>
    <name>A0A367JMW0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000995">
        <property type="protein sequence ID" value="RCH91267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMW0"/>
    <dbReference type="STRING" id="86630.A0A367JMW0"/>
    <dbReference type="OrthoDB" id="2248794at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="218" mass="24636" checksum="CA9ED27C461BBE8D" modified="2018-11-07" version="1">MSKAAKQISNLLSDDDCNNHDDMVILRIRGLLEVSPSTSSMAKSMKVKLDAFTLNIRALESNSKQHDFGGNVLENSNWIGPVLVREVKGEGRKDDVYMCWMDLYRISSLSMESINYNRYKGIIGIQVIGMQATFYISTLLSKGFYVMMEICSITLPKGLTEILSYFANLSDLLPVIQCYKNCFELVNNVISESHMNTFDAKKIICTSKHRKCPVVLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPC0</accession>
    <name>A0A367JPC0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RANBP10</name>
        <name evidence="3" type="ORF">CU097_007932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000929">
        <property type="protein sequence ID" value="RCH91725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPC0"/>
    <dbReference type="STRING" id="86630.A0A367JPC0"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="525" mass="59773" checksum="CD257AF9C0F2B565" modified="2018-11-07" version="1">MISKYPAYLKYTNYAQLVSEQYDQMMKEVDLRLPQFWNKHDKARYIDVGMNGYDLYYSGPGKKELDAATIRTNFPIRPQCGIYYFEIKVTSKGEDGFICIGFCRAGNKLERLPGWDAHSYAYHADDGHIFDQCGRGKNYGPTFTTGDVVGCGIDYANQTAFFTKNGLFLGVAFKQVDLSEPIYPCVGLRTPGEKVSVNFGQEPFVFDIVQYVKEKKAQVIRDVVSRDNKVDQDSMDQIVLNYLVHHGYIEAANAFQKNLSYIKRTPYSTFPATSQYTQTRFNIRKLIIEGKIDETIEQLHIAYPGLLNSRPDILFALKAQKFVELIRHSIQQHHHHHHHNHFHEETKSNDYLQNQPLYEEDNTDHHTTAIQHPPPVSVPAPGRRLSWAAIAASPTHPTFERRSSNASSIHSLDYFDEEHGYIRKAMNYGQKLQEEYNSNPSYRASLTEISSLLAYPNPTTSPSAHLLNKSARDSLASDVNAAIQMYQHEQQESSLERVFKQVTVTLQQLALTGHGQATLVQTDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPL1</accession>
    <name>A0A367JPL1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CHT1_1</name>
        <name evidence="5" type="ORF">CU097_000585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000910">
        <property type="protein sequence ID" value="RCH91858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPL1"/>
    <dbReference type="STRING" id="86630.A0A367JPL1"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016696497" evidence="3">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="40"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="423" mass="47742" checksum="44AD04F54F4CBA05" modified="2018-11-07" version="1" fragment="single">MYIALLLLPLVIFAIKLASATPSHSEFSPIKSRNVLDRSDNVVLYWGQGDFGERRLSYYCDQEGVSIVILSFITDFIGGPRKSPIINLADNCNDVENCVETAQDIKYCQSKGVKVLMSVGGAAGSYHKQSWDPDLFAWWLWNKFLGGDDRTVPRPFGDAVLDGIDYDPEETTGKGYDRHIHTLRQLFQTQYPPRQYLITAAPQCSDLDYYPKNAQYNILHPSPQYDAYPDMVFVQFYNNDCSAAAHKPRGFSDFNFDAWNKWAQEATKGRTKVLLGVLGRDNRMDTGYVSYDKLTMILDDIKSRSQFRGVMIWDAGYAYANKVPYFNNLAYGQATAKYLRQLATNSKPGTKLIETIDMALQENQMPIMIPVRHDARLPCKGQAMMLLKTVSTRILAQSFGASPEILAERFEALGVSGDEPLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPU7</accession>
    <name>A0A367JPU7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_004307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000894">
        <property type="protein sequence ID" value="RCH91974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPU7"/>
    <dbReference type="STRING" id="86630.A0A367JPU7"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="975"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="382"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH91974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127334" checksum="76943F45A6D8760C" modified="2018-11-07" version="1">MSNNHRPNSNMYRGSPDPRLSYQQQQQQQQMRQSQIRLNQYRQSNIPPQQYNMDHLSRPRPPAHRHHPDRQSQVRTGRPMRPPYHHPQQPMVPNQPPTATGPYRRVSMNRSRSLSRPERQRPRPGMIRSPSQQQRMMQQQMQQQRMRPPRPSNYPMPNRLQHQLQQQQKMYQQQQQQEMALLENNKKENNDANIPEEKIKVLTSWWAWLAYLMTCCIPNWFLRVCLRKRNPMVQQAWREKLSLCYIILILCGALAFITYGLNRALCPPSSQASNTPYSQVVDGQRIPVYHENPRVFGQIYPMDALKSFFATKGLNLTNDYQNAELSGIFDGDTGGYCRGFPNTLPACQLIDPYGGGMLPPNNTCLSLAELQAFYHSRYGVLGFDWEDLNKHSITGQSLALLGDSVLNLTSYLQFTTPPFGEAVDRAIRSNLAADLSYALLNTPNGRAARRCLEARYRVGVMETETAGCIADKIIMNLMLVVIIAMIVVRYCMALLFQWFISSRLIKPGGRSNWLAWRSIKGGNDDPANHIPGPYNNYGPMQLQNSTTSLGSGSSSRATPALSEQSSAVGLGGARSDIVTTELYTVMLVTCYSEGEEGLRTTMDSLAETTYSKKHKIFFIIADGMITGAGETKSTPDIVISMMDLDPTMSNPKPSSYLAIADGEKQLNMAKVYAGHYKGVPCITIVKCGTEEEANAPKAGNRGKRDSQLILMSFFQRVLFNDRLSELDYEIFWKMTWLLKGVTPDKFELVLMVDADTKVLPDALTYMVAAMANDITIMGLCGETRIANKRASFTTAIQVFEYYISHHYAKSFESLFGIVTCLPGCFSMYRIKSPKNGAWVPILANPDIILEYNQNIVTTLHEKNLLLLGEDRFLSTLMLRTFPKRQMMFVPQARCKTVVPDEFKVLLSQRRRWINSTVHNLMELVLVSDLCGIACLSMQFSVFVDLIGTLVLPAAIVMTIYLIIDTAVSSNPQWQSLALLIVILGLPAVLIAITTFKLIYVLWMFVYIIALPIWNLILPLYSFWHFDDFSWGATRVVAGEKKDKGHGDAEGKFDPSRLVMKKWEDWESERTGQKFNKKMTLKTPLDSPSAFDGKNTVTPTTASPFGNIFNDRKMFGASPASSTTNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPY9</accession>
    <name>A0A367JPY9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000924">
        <property type="protein sequence ID" value="RCH91761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPY9"/>
    <dbReference type="OrthoDB" id="2245662at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="102" mass="11549" checksum="7BBB1D3BC1168C96" modified="2018-11-07" version="1" fragment="single">LYGARISLTLLAKSVLKEDGLTFSFAREEFLVDGSYFIHYHAQSRVILLEIQPNVTSISLKRSIKKCLEVQNDIDVQLFLILLCTDKIPLSVMLLPDLQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ01</accession>
    <name>A0A367JQ01_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COPII coat Sec23p-Sfb3p heterodimer component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SFB3_2</name>
        <name evidence="10" type="ORF">CU097_011629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000896">
        <property type="protein sequence ID" value="RCH91965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ01"/>
    <dbReference type="STRING" id="86630.A0A367JQ01"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="6">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="7">
        <location>
            <begin position="305"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="9">
        <location>
            <begin position="544"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="902" mass="101145" checksum="12BCB8082D4DAE69" modified="2018-11-07" version="1">MDNSQFRAPAMTQPPPGSHQHLYGAHNVPPQFTQQDQPTIRSQPAQPLTHSSAPQHNADQLANSISNMNIHSDSQRAGRSRRAYAPIPPTPRAPPQPPNNYNSPPIPQVNQQTPLGLPPQTKKPRIDPNLLPSPVELQVRDADRCERPDYYYGTCTEEAPPLASTNFKCIDQGNCNPRFMRPTLRDIPSDSNLVQDTGLPFGIIIQPLAQLHPEDANVPLIPLSTDGPVRCSRCKGYINPWCQYIDAGRKFICNLCEFTNIVPEHQFCPVDIVSGRRMDMDQHPELMHGSVEFQVPEEYWLGVQPRPLHYMFAIDVSRNATGMLHQFCGAIKEMISSNCFQPGTKLGIMTFDNSLHFYNLQSTSDTANMMIVPDPEDVFIPLLEGLFVDPYESRNVINKLLDQIPNMFQSNPVSTAAFGSAARAALLALKNQGGKVISTLATLPTIGQGSLKDRNDTSLYGRETEKSLFTPQGNFYTKMGNELVEAGVSVDIWLAPPANYYIDVATVGVLSALTAGEIHYLPNFDISFKQMYHNLRHTVQAEHGYRAKLRVRCSNGITTADHYGNFSMDTATDIDLAGIQADTAIGVELTHDGSKLTKDVYIQSAMLYTTSNGERRLRVHNLKLAVGTTVASVFKGADAGTCLNLLTKKFITLSIKKSLSDLSNELDQLCVKVLLNYRKYVTPQASPAQLVLPETVKTLPLLISSFKKSILLRKDSSINADTRVYTMRRIKSAGIRETIRWFYPPMIKVHEWLMQSDKTKYPLERLSYEKMDPKGIYWIETYGSIFLWLGKETPSELINLAGVSDSAMANPIDVLQENNHPLWNLYNRSMGSHCTCLPKFQIIRQGLDLEIELAKVLVEDEVYSQMSYPDYLCELHRQIKLELGREDQQTAISAASYWAYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ96</accession>
    <name>A0A367JQ96_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_009925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000874">
        <property type="protein sequence ID" value="RCH92122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ96"/>
    <dbReference type="STRING" id="86630.A0A367JQ96"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="448"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH92122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="793" mass="90424" checksum="81CF42C29E44F177" modified="2018-11-07" version="1">MERPKRQSTVDKNYREHKRSKKGETASSPTKEESLSPFEQLYRDVVNYRDPEDEDYDITAIFMKLPSKKEYPDYYQIIKQPIALETIKNKVDKNMYQSISQMKADIDLMVSNAKKYNMKGSQIYEDAIKIQRYVKGWQGVKEKAVLKLPGEAFNSAPKIKAIKLKAIDKPKKSSINTKALMTTIIKREVKGALELLDTDPQIDPNELVPAEMFNDKFTWGPLHAACYYGDIKLVEALIAKGAEVEKQDTWHSATPLGWAAFGDKHNVVRLLLQKYNANKNAKNVHGQVPFELVSNQDDPRWIGLFKDTPSVQQQQQQQQEQQPQPQQMKQEPPSQPSQPPPSIPLSQQAMPPPLPQQQSVQLPMMPNTMPMVSVPQPIKAFPTIPGVRQPVYQTSPDGTIRKRRGRPPKSETDALAVRPTTEIDINTFDPVAFEIELFNAIRTHTDNSNRLYSELFEDLPDRHEYPEYYSVIKNPRSLSEVAEKMQTRSYPNLYAWMSDMKLVFENALKFNEPGSRIFRDAKLLLRLLHRLKERILARLGVPVSQEDAIMRLDLASRPFDAEALSEDKRKIKRFLTSSKSRTQSIEPDHHHLTYQQQATATPMIHPLLLQQQQPQAQSSFLQPPPPFLMQPPLQSLPMMTPNAFMPPPQPPMMEQHNIELPKSPLTKASKEFYAVFAEGVGSFLNELTVSSKDFSQRLTGDYFGHSIVVPPGTQTLDIQTDLPKPLKNEDKRITITVLQNNVKLNPTADLSWTTVPLTKGMNVIKINVTANLSQPDSTVPEFKSQMYHLFITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQB2</accession>
    <name>A0A367JQB2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_004878</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000907">
        <property type="protein sequence ID" value="RCH91881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQB2"/>
    <dbReference type="STRING" id="86630.A0A367JQB2"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000037">
        <property type="entry name" value="Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="230"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="633"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH91881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="781" mass="87786" checksum="AF677F338ECB5501" modified="2018-11-07" version="1">MSKLNLTLPKLAPNTKPFANALKIHIAAKVKDIKLNEVPGEHVSLVLSDEISLTDANAAVKYLLNATRFDVSLESILQSSVIEKEETVISPFIIKRRLDQAFQIVEETLAKYRNLFAKVSDDVGFLDVIYYGALVEAFASFKEPSKYPLLAAWFDIVSKNTKVAAAVEYVKEQNSKGTKSKKQGHAEKKVTKEIPKPTVNPATQKVNTNVAIKPVDKNVKVLPKEGARNIMITSALPYVNNVPHLGNIIGSTLSADVFARYCRARGYNTAYFCGTDEYGTATETKALEEGVSCKELCDKYNAIHTEVYKWFDLSFDLFGRTTTERQTEIVQDMFKKNYANGNVVKESMIQLYCEQCHRFLADRYVEGICPLCQYNDARGDQCDACGKLLNATELVEPRCKLDGNRPILKESNHLFLDLTKLQPAIEETFKQSSTEGGWSANGIHITESWLKEGLKPRCITRDLKWGVPVPLEGYEDKVFYVWFDAPIGYPSITANYTDEWEKWWKNPEQVKLYQFMGKDNVPFHSVIFPGVQIGTGEKWTKVNHISTCEYLNYEGGKFSKSRNVGVFGNNAKETGIPPSVWRYYLLSVRPESSDSMFTWSEFITKNNSELLNNFGNFVNRAIRFIFAKYDGVIPKADFNGQLETDLFKDVNALLKQFVEQMEAVKLRAALGTVMALSARGNQYLQEANLSNALFDESRPKCDAVVASAANLIYLLSALVSPFMPATSDSMCRQLNAPARNIPDEFTLDILPGHVLGGAEYLFTRIDEKMEQVWKSKYGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR84</accession>
    <name>A0A367JR84_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_007975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000834">
        <property type="protein sequence ID" value="RCH92395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR84"/>
    <dbReference type="STRING" id="86630.A0A367JR84"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="755"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="876"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="937" mass="102156" checksum="48ECB7D990FDE24B" modified="2018-11-07" version="1">MTSGIRININSWYGQGGGLGYVQIYQSDISLHPSMFIGNSTCQGIPSSSITVTGNWQEVYVYGYYQTVLEAKISTFELDTTNTSILYEPHIPLLAQYNIYATTPGCVGSANCYQRTQVEYQLQLLPGQSIVVYLDQNVFEDTRTLLYSGLVMPKSNNFRPSITLRPAFNATIQGTATIMADNLDLIRNSSTILPIISILEYNLTLAQNASAVSWKALNEQLPFNSTVYSIDASAGDTIYIGGEFLCLNASGGYRNIVSYDYLSRRMISLNGSGLNGKVSKLVSYKQSRLFVAGEFNSTAMLNISLPYIVEYDIQQDSWSVLKDGVNGPVNELLLSSTSDTLTLSGNFSCQYLTNKQCIKCGGVAQWNIQSNSWENTSSLIIGDLKAVLSNGSQTVLIGNQLNAETYRADFVTISSSQLIPYTFDDNDTFYPVYITAGTVDTKNSTFVSRHFANDNITKILALSNNKWVVIDEVQGYVHSMLAINNYLCVGGRFQSNRTTSFSLYDISMNFTKIPIHGIFYNNQPGAINVIKAYPDGKSILVGGSFTRVGSLECDAVCLLDIRTLQWNRVAFGVNGTVCDMLVSNRRDITIFGDFKAHQNNATVSKLNDQANFWSVNTNSLPGIPTSAIVEGDNHTFIVSGYIRGNSSNQFFIGTLQDTTYIPLNDSRLGFDTIINQILFLPASDAIHNYPDGTKDVLLAVGDIHILGIGRVSAAIYDGNDWFPYLTSIQWSRRPALIQAVVHKSSFYTPSPPHHYLPVTAVVLISIGISVGILFAMSTAGVLYVFKYHGAQDGPEQMPPYDRFLDALGLAAGTSLGVTPAVAAIAGSSNAPEELSNKVVSSEPQTSGAATTSVSIVSFASLAALAKTNTSSIINETHPKLFSAKYPFKAQEHGELDLNKGDQVVVTDTSDNVWWLGYKDNGAGKPISGVFPSNYVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRK4</accession>
    <name>A0A367JRK4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PI31 proteasome regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000844">
        <property type="protein sequence ID" value="RCH92331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRK4"/>
    <dbReference type="STRING" id="86630.A0A367JRK4"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="14910" checksum="55C675F0FCD87B99" modified="2018-11-07" version="1" fragment="single">MSASDPLDPSAVLQLTSQIITRLELPYDALAAAMHAIMLSVGFRFAGLGDDARQEGDGTQRNLPAEWNQHGPHYYHFRYSHPQSSLTFVIKVVRMGDKCVILGIGIGDNKTVVLDIATDDYTSASFFPNDLSNDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS65</accession>
    <name>A0A367JS65_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_001837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000788">
        <property type="protein sequence ID" value="RCH92725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS65"/>
    <dbReference type="STRING" id="86630.A0A367JS65"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="772" mass="88541" checksum="331E9E17B8DC9675" modified="2018-11-07" version="1">MEGYKTCKNCILAKEGCTYNIPIKKRGPPSGYAESLENKLRRIESILTKASSIRKRDRSPERKDISAEKLNDVIIRRMIASNASKQQQLKSINKDLFIDLVHAIIPPVGLCLQKNKDVLQVQKEESANLDEKIDVIDDAIDSTFIRSRDEVRTIDQWVQKMVGIDKDLCDRLLRVTPVVNKTVFLQEYRGIRPNFPPALLLIAICLTTVRYIRLRTAFGDTEDLNDGKPWNLSDKTSNSLFDRLSKYVFKRSRWNLTAIQTAILILVVPFKEQRWERHWLISSRGLQGCLLLKLNRSSEALDISHDEKETRRRCWWSAYILDRLYSAESGKPLGVLDEDCDELYPSEFASYDEVMDVMTETDQHLPRFPSLDEKTAQQYKGDIPLYRPFVHMIKLSKILGITLQNLYTPKAQTYCVEHGSDAIVAFLDNELSNWRASFPPLSETSDQTSIFPTSGIISLVYYTNLILLHRPFIKVNKDSNKNTKFSAQTSLAICTSAATKIVEISKKMRYKDYILVSCGYAFYPIVTATLIHIFNACNPEKSVSDPAKMNLLESLDMIDKLNHTMSSEDAIEMMIRKSVLRSKLCTHDPVFAKMLHGQEQKPKEVEEDKANPDFGWLDNLYDASQQVNQNNLPTSSNNNSNLALLQQQQQQQQQQRTTNMNDMYSIRQFNFNPVSQNVIEQSNILQWYPLLPSYNFNTPVPPLHTVPSQAVSYDTLHNHLMLTGMNNNIEQTNTFTMPLISHDSMDLFENSSFWGTPDSTGFCSSLYDYLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTL7</accession>
    <name>A0A367JTL7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_013398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000720">
        <property type="protein sequence ID" value="RCH93258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTL7"/>
    <dbReference type="STRING" id="86630.A0A367JTL7"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="70"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="445" mass="50049" checksum="32DC14CC5CC971AC" modified="2018-11-07" version="1">MEQTSTVFYGTIAHSLSPQVLEHACNTVIVVDNSTGVITHIERDVQHLESFLKHANLTDAKIHTLHHDEFLMPGLVDTHAHAPQYVFSGSNMDHQLLEWLNAHVFPCEAAFNDTKYAAKIYRRVIQRFLANGTTTCSWFATIHLDACKALVDIIDELGQRAYVGKVNMDQNSPEFYIESTESSLKDTRDFIDYVLSKKHSLVTPVVTPRFAISCTRKLMDGLGELAKEYDLPIQTHLCENLKEIELTKSLFKDSKDYTSVYDKSNLLNEKSYMAHCVHMTEDELTMLAERKTGVAHCANSNFSLHSGVCNVRRILEKGIKVGLGTDVAGGFSPSMLDAVRSTFFASKTMKIMKQSDDYKYLSVPELFYLATLGGAKVLNLEQKIGNFVVGKAFDALWIDLKHGSVDLMGEECVPQKVEKFLFNGSDQNIRHVYVQGKRVAGRRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTW5</accession>
    <name>A0A367JTW5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ATE1</name>
        <name evidence="8" type="ORF">CU097_012658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000709">
        <property type="protein sequence ID" value="RCH93356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTW5"/>
    <dbReference type="STRING" id="86630.A0A367JTW5"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="158"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="384" mass="44794" checksum="5D9FCA0F374C27F7" modified="2018-11-07" version="1">MNSDDEYDLLKDHVSALVSLCGDSQHDCGYCDGKDTSKSFGIWAHFMSCSDYQALIDRGWRRSGHYLYKPDMERTCCPQYTIRLHAMDYKLTKGQKKVLNKFNRYIQGTWSPEREEQQDVKNKPKENTPKSLLDWVHAPDHTDNKYKLKLEPSSYTKEKHELYKKYQISVHHDEPEELTERKFRRFLIDSPLKMETKGDVTFGSFHQKYILDGKLIALSVIDILPSCVSAVYFMYDPDYSFLGLGKYSVFREVSLVLELKDDDLKYYYMDSCPKMNYKGQYEPSDLLDPVDYTWHPIQEFRKEFTKHKFVTFAQGIEYTTAGWLNRKEITQSVLSNVLVYIGEGRVLPAKHLLQAIKDPQIRASIIDFVCAVGLDLAYSILISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUM8</accession>
    <name>A0A367JUM8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoadenosine phosphosulphate reductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000704">
        <property type="protein sequence ID" value="RCH93391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUM8"/>
    <dbReference type="STRING" id="86630.A0A367JUM8"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000136">
        <property type="entry name" value="Probable phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="275" mass="31851" checksum="5BA8D0F7946666D3" modified="2018-11-07" version="1">MPSSTFTTKIQSGNDLSPERLEQLNHYLSTLEPKEILEWAIDCLPNLYQTTAFGLTGLATLDMINKISIDRNQSHIVPLIFLDTLYHFKETLDVAKRCEETYLVPLKTFKPMNCNTSTDFEREYGQKLWETDEDAYDYLVKVEPARRAYEELNVKSVITGRRRSQKGDREAIPILEVDSTGLIKLNPLAYWDFQQVWSYIRANEVPYNALVDQGYRSIGDWHSTKAPVNGDERSGRWSDKQKTECGLHKDYFKMRAAFMASKKKREQQQQSMIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVM1</accession>
    <name>A0A367JVM1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZRT3</name>
        <name evidence="6" type="ORF">CU097_011197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000632">
        <property type="protein sequence ID" value="RCH93986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVM1"/>
    <dbReference type="STRING" id="86630.A0A367JVM1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="272" mass="29383" checksum="9648CDD452732B1B" modified="2018-11-07" version="1">MYEGWLFVSMSCLSCILGASIVFIGEKVLENKRFLSGSMALGAGALFCNVQFNLLPTAYQKLGLLPVVGWFLIGVLGSICTNQLIHYCTPHALHTCDLPVKSYGTIDEESLEHSDKENYYLIGIQTAVAICIHKFPEGLIMFVSNESSGQLGLRVAVAMMIHNAIEGLLIALPLYYAVGSQLAAFGYAAVLGGLSLPIGALIGYIAVTGVDKAREDALFGILFSLISGMMYMVVFKNMLPEAIKSRPNNLFVLIFFVLGLGLIEIISLLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW57</accession>
    <name>A0A367JW57_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smg-9, nonsense mediated mRNA decay factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SMG9_2</name>
        <name evidence="4" type="ORF">CU097_011796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000614">
        <property type="protein sequence ID" value="RCH94128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW57"/>
    <dbReference type="STRING" id="86630.A0A367JW57"/>
    <dbReference type="OrthoDB" id="79514at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="40131" checksum="528708D3D5B7FD3F" modified="2018-11-07" version="1">MTDNGQTKKRGRKQAAFTRAPPIILDRRERIESKSTSTEDKKEEAKDTVIPFMRRPAKFNTDAILKNLTDYPGHFVIGIIGKQGVGKSTILSQFAQLDQVFSTQPCDQFLISGHKTEGIDMYVTPERAILLDTEPVLSWSVLEKVIRTENLDGLNPDVWLEIDSIYTVLFLLSVCHVVLVVNDKPEIDLDILQLIQRAEALKFNIPDYPLLTGQQDMNYYPDIVFVCNKCKSHDFTLEKYMNLQTALGTIFKQSQLKTQGLVQLGSILPSFITPGTINIFFLPDQQDNTIESFDILACELRDQVTAAPRKSGKKGQVSEKDWFKNAYKIYELIHKSDYITEYLQVVRKLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXB6</accession>
    <name>A0A367JXB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000563">
        <property type="protein sequence ID" value="RCH94570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXB6"/>
    <dbReference type="OrthoDB" id="2274850at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="539" mass="62819" checksum="101C316719CCA21F" modified="2018-11-07" version="1">MFGIYFLFSFRGILFACIVAFLLYIIRGYPQWKTDRQEQQQQQQQQQQPAETVKSTEHKQQENNIGNLSIAHYILVSPFAALYILARVIFDTVRFSIYYALWTIERAMPYVDDWLFETVTVSLPTKINQCSQWWEERGGPAFYAYQANFRQHTLPVALQYVENTAIAIYRIGCAIQSLSQETMVAWRKFINAHDWKQLAEDLCEIGYRNIWQPTTAVISRIMHLCRLVYQGAAHLYISVKNDMVWIATVVVPTVYDYCASTRLVQFLQRVIMVSRRALLWVGAQIKDFVLAPTIGRILTWLVKAIDQLLLMLQTHQFQQRLEIMYIFLAPHIVWTLSECCLLGSYLASLLEAAYSQIIYPAYRLYVKHVVPQLSATYHQLRDKVSQYFVTYIYPTWLRVVLYLEKPAAWLYFKIGPLVHTVCKHLFDVIGAYLTQIVEYTHIITSQCLKATLILTHRMYMALQSWLTKQAPLLSSSLQQVSGYLYNLNWQAMTNEVTSIIYAIYQWTTEQGGLVYASFERSLTTWVKEQAKAAKDIKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXU1</accession>
    <name>A0A367JXU1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000547">
        <property type="protein sequence ID" value="RCH94705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXU1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="104" mass="11451" checksum="911B548CA97A394D" modified="2018-11-07" version="1" fragment="single">MAAKKRSLENDARAIGNHVNLRVLVQAKGTHEDALSDEFAGSIPGPQKFTGDHTSACDGEVKAMKLNVPCLYTVQHFSSVPIPNDAGDLDLLRKKYLPRLEYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXY7</accession>
    <name>A0A367JXY7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000541">
        <property type="protein sequence ID" value="RCH94767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXY7"/>
    <dbReference type="STRING" id="86630.A0A367JXY7"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="308" mass="35376" checksum="281A49BA1360899B" modified="2018-11-07" version="1">MLLSPEERASRIRSYIEEQRTYAPYYEPPDEIPVSIVINDDDDDINCNSLLMTSVSQVDVNQTSTTRNRSNQTSIGRENGKKRKDMNHELKKPYVTSTKPNGLHLLEKFTSPNIEIDRITIKSRKRNRPPSLGLFNKGKSSAKGKLNREVPDLVFSEAEFLKKQTKEDQISVHSSVTKRNPRRTEKKSRFFKKQDDKRDERATFGQKQQPCAEDDNSSCGCCEILSDYDDNENGAILAEDDCGLLYSNSYCSYSQIPSYSYVRSPCILPITTGYQSIDWQIEANQDDDSDALTLKRNQLDTFWIKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYC3</accession>
    <name>A0A367JYC3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000521">
        <property type="protein sequence ID" value="RCH94946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYC3"/>
    <dbReference type="STRING" id="86630.A0A367JYC3"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18073" checksum="7F98AD8712A11957" modified="2018-11-07" version="1" fragment="single">MQQVAVNYAKHKFLGKASQHIHQNKPSFETDPEVLRAIEEAQKHHKTHWWQLNKKAQNSPEILLNQRDRQVLHQVKKRAWYLDKGCHCCCFNIGLDGIVGLIPGIGDVIGTALALQLVRTACQADIPNWLIAKMTWNVMLDFMIGLTPIAGDILDILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0H7</accession>
    <name>A0A367K0H7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GDI1_2</name>
        <name evidence="3" type="ORF">CU097_011864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000446">
        <property type="protein sequence ID" value="RCH95645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0H7"/>
    <dbReference type="STRING" id="86630.A0A367K0H7"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="442" mass="49406" checksum="281B9D3E8CB1C127" modified="2018-11-07" version="1">MDVEYDVIVLGTGLTECILSGLLSVDGKKVLHMDRNDYYGAESASLNLTQFYSKFRPGESVPDHLGRDRDWNIDLIPKFMMANGEIVRFLTHTDVTRYLEFKQIAGSYVYSGKKVSKVPANASEALSSPLMGILEKRRMRNFMLWVEAYKDEDPKTHQNIDINTMTMTDVYNKFGLAKGTQEFIGHAMALHLDDTYLTNPARDTVEKVRLYAASVLRYGKSPYIYPLYGLGDLPQAFARLSAVYGGTYMLDKDVKELVYNENGQVIGVKAGDEVVHAKMVICDPSYAPSKVRKIGSVVRAICLLTHPIPNTNDSDSCQIVVPQNQIGRKHDIYVACVSDAHMVCPKGYYLAIVSTIVETNNPAEEISEGLKLLGPIQDKFVHVSPLEEPIEDGTKDNVYISRSYDATSHFETVCDDVHDIWRRITGGPLVLKKREADDVNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1J1</accession>
    <name>A0A367K1J1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(adenine(34)) deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_013345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000407">
        <property type="protein sequence ID" value="RCH96046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1J1"/>
    <dbReference type="STRING" id="86630.A0A367K1J1"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052718">
        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000039">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="179" mass="20263" checksum="88D48EE5324278E2" modified="2018-11-07" version="1">MSQYNAKFMKAALDVAQEAYDNLEVPVGCVFVLNNETILARGRNRPNETCNATRHAEIEAIDLILEEHDPTIFSNVDLYVTVEPCIMCASALRQIGIRHVYFGCGNDKFGGNGSVFNMHSDPRLETDHSKGYESKGGYFYEEAIMLLRKFYVRENQNAPVPRKKANRVLKTEIAPKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K292</accession>
    <name>A0A367K292_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Golgi to ER traffic-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GET3_2</name>
        <name evidence="10" type="ORF">CU097_010615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000384">
        <property type="protein sequence ID" value="RCH96277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K292"/>
    <dbReference type="STRING" id="86630.A0A367K292"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="329" mass="37209" checksum="B964CDE4F396A860" modified="2018-11-07" version="1">MSDMSDDEFQPLEPTLQNILDQPSLHWIFVGGKGGVGKTTTSCSLAVQLSKVRESVLLISTDPAHNLSDAFGQKFSKEATLVNGFSNLYAMEIDPTSSIQEMIEQSEQNNPMGGMMQDLAFAIPGVDEAMGFAEVMKQVKTMSYSVVVFDTAPTGHTLRFLSFPTVLEKALAKISGLSSRFGPMVQQVSGMMGMNANQEDMFSKLEEMRSIINEVNKQFKDPNTTTFVCVCISEFLSLYETERMIQELTSYHIDTHNIVVNQLLFPKEDSNCEHCTVRHKMQQKYLDQIYDLYEDFHIVRMPLLTKEVRGVEEIKEFSKMLVEPFQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K363</accession>
    <name>A0A367K363_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000356">
        <property type="protein sequence ID" value="RCH96579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K363"/>
    <dbReference type="STRING" id="86630.A0A367K363"/>
    <dbReference type="OrthoDB" id="2269686at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="35"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="419" mass="46374" checksum="59D0362AA2B85687" modified="2018-11-07" version="1">MLQSQVINVLPRRILASLWATSETRIALSHFAVNKEQPTAPMAISSNFLCNELPIRYTHILRLLSALSPESLQSPIIKNVAHSYLCDICTLLHPSLKQTSPKALSNVLSKLRTSQAVNSIRLRYAFLSSPTPACLNLMDNINTIGIGIHHLLDQHISWVTNKLNHAQTLHPEDITRQAVHDAQAAFSGAYGTAYLPQVEIKARTKQELVYIPSMLHRIIYESILLCLKAQAMHDQEQERTARWYRRPFMKSQPMTLSIFGGPTSVGFKLDTAAFIPDKDLLPSIPRDPIGIPTCSSVLSSTSRTSVDRVEPNHALEWASLSGWRIARSLASHWGGNLDIVNVDGLGSTVYLALDRNTQILERYPTFRAPQQDAVPIQTAAAQLDAFLYAISNAQPISTVIPTPLYHHHSVSLTAAVGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3V9</accession>
    <name>A0A367K3V9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_014415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000330">
        <property type="protein sequence ID" value="RCH96868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3V9"/>
    <dbReference type="STRING" id="86630.A0A367K3V9"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="362" mass="42123" checksum="568353C012883C28" modified="2018-11-07" version="1">MDSKETQPQQQQPKIIKIRRPREPKSMDKKEKTIKIKLTARENKHEGRQSTASDDEEEPEAAIEEQLIFRVPEGPMCEKLHELVKKREIPADVKLHFKDNRKGTFTFDGKEHDVLLVDLPTIIEAQKTLDKKQFYKVADISQMILVDPTTANEPFIPQANGRHDTDPYNFPHGLTPPLKHVRKRRFRKKLSKRAIEEVEREVERLLEIDATAEDVQYEVVDDREIEMEQESDAATQEIDIDDSGDESESDEDLAAAIDRDLEEMEEEDDDDEDEEEEESDEEEEEENGQAGDTEQKRQEIAEIKQKRQEIAELKQAIQRKTRDLLTAPNAMLKNRFETDINNLKKSLTLKEAHLAEMNEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Y6</accession>
    <name>A0A367K3Y6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000327">
        <property type="protein sequence ID" value="RCH96898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Y6"/>
    <dbReference type="OrthoDB" id="411535at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026721">
        <property type="entry name" value="TMEM18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14770">
        <property type="entry name" value="TMEM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="150" mass="17040" checksum="B8D70FCACDEADA05" modified="2018-11-07" version="1">MSTTQNDIVNSILEAMKSGQGYNSSAGRSLMFLNAVDWTQPWIISIIVFHILCFIMAICLRNHHNSISIYFFILLGFASLTQKLNSLGMKYWQSFSNTCYFEPSGVFIVSVYAAPLLVNAFVTMMLIIKAVVSLMVETKRRQLQQKIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5W4</accession>
    <name>A0A367K5W4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP citrate synthase</fullName>
            <ecNumber evidence="6">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Citrate cleavage enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ACL1</name>
        <name evidence="33" type="ORF">CU097_011456</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33 34">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="22">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000266">
        <property type="protein sequence ID" value="RCH97567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5W4"/>
    <dbReference type="STRING" id="86630.A0A367K5W4"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="32">
        <location>
            <begin position="2"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="31">
        <location>
            <begin position="296"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="30">
        <location>
            <begin position="543"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="29">
        <location>
            <begin position="709"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="28">
        <location>
            <position position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="RCH97567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128900" checksum="62CAF7218DCB7005" modified="2018-11-07" version="1">MSAKAIREYDGKLLLAYHLLRVPVPNDTPSLFTPAATKLAQINVNTSLLNGPAGAFDAALKQQLDNLEQTHPWLLTDKLVAKPDQLIKRRGKHGLLTLNKDWSEARKWIEERAGKEIKIERTTGVLKTFLVEPFAPHPANTEYYICINSVREGDYILFTHEGGIDIGDVDAKALKLLIPVNAEFPSAQTIKDTLLKDVPEFKHDVLVDFISRLYAVYVELHFTYLEINPLVVTDPVEGQTPQVMYLDLAAKLDQTAEFEAGPKWAIARAPQNIGLVADQQHVDQGPPMEFPAPFGRELTREEAYIQELDGKTGASLKLTVLNREGRVWTMVAGGGASVVYSDAIAALGYAHELANYGEYSGAPTETQTYEYAKTILDLMTRGNVNPEGKVLFIGGGIANFTNVATTFKGIIRALTEFKQALINHKVRIFIRRGGPNYQEGLRAMRQLGETLGVEIQVFGPETHITDIVPLALEGKSNDVAKQQQSASSGNLFQDQIFGTPSGTNTPKLTIAEDNNSPTNPNDRMTYFATEAEESAEWYRPFTSKTRALVYGMQPRAVQGMLDFDFMCKRETPSVAAMVYPFGGSHVQKFYWGTKETLIPVFTSLKDAVEKFPEVDVVVNFASCRSVFDSTREIFTYSNQIKTVAIIAEGVPERRARQLLHEAEARKVLVIGPATVGGIKPGCFKIGNTGGMMDNIVASKLYRSGSVGYVSKSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFIDHLLRYEADPNCKMLVLLGEVGGVEEYRVIEAVKSGQIKKPIVAWCIGTCAKMFTTDVQFGHAGAMANSDLETADAKNKAMRAAGIIVPETFEKMPLALAETYNNLVKDGVIIPRPEPEIPKIPIDYSWAQELGLVRKPASFVSTIVDDRGQELLYAGMRITDVFKEDIGIGGVLSLLWFKRRLPDYACKFIEMVLMLTADHGPAVSGAMNTIITTRAGKDLISSLVSGLLTIGERFGGALDGAATNFTKAYDSGMTPREFVTSMRKANKLIPGIGHKIKSRTNPDMRVELVKDYVKKHFPRTPILDYALKVEEITTSKKDNLILNVDGCIAVSFVDLLRESGAFSQDEAEEYMRIGTLNGLFVLGRSLGFIGHHLDQKRLKQGLYRHPWDDISYLLPSLDPETLDPRRVNTRVNVQPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6F4</accession>
    <name>A0A367K6F4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myo-inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ITR2_2</name>
        <name evidence="12" type="ORF">CU097_008527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000279">
        <property type="protein sequence ID" value="RCH97421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6F4"/>
    <dbReference type="STRING" id="86630.A0A367K6F4"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH97421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="492" mass="54039" checksum="F1F17236355BF90D" modified="2018-11-07" version="1">MLNNHVERQHYERIPSTDNVPVETEQSEKITPFVYSLVSCVCLGGFLFGYDTGVISGALSPIERDFIMTTRQKEYIVGGTTLGAIFGGLIAGSLSDRFGRKPLVLCASIIFVIGSGILALAQSYSMLLLGRLIVGVGVGTASMIIPVYISEVAPKDFRGRLATLNTLIVTFGQVVAYIVNMIFARTEGGWRYMFGIGALPAAIQLIIMPFMPESPRRMVLTNDIMAAKQTLQKIYGQHVSEAFINREIEAIQEDMQNSSLGTYQDFKRPENLKPLMIACLLQAAQQLSGFNTVMYYAATILAMANFNDPTAVALVVATANMVFTMIAVNIIDKAGRRRILILSMLSMILSLIVLGGSFAVQQETFSFLNVDCVNAHSQSCSDRSTIMIILLLSLTSYVASYALGLGYIPWIIQGELFTLQLRGKANGIATTTNWVLNLIVASTFLTMTKLISISGTFWLYAVISSILWLFIVKLVPETSNKRLEEISAMFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6T8</accession>
    <name>A0A367K6T8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000240">
        <property type="protein sequence ID" value="RCH97887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6T8"/>
    <dbReference type="STRING" id="86630.A0A367K6T8"/>
    <dbReference type="OrthoDB" id="2377384at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="32185" checksum="A3A7E79BA56A6250" modified="2018-11-07" version="1">MATEEVNGVQENSGGFVRLGRSTTGADIGELQQKISQAEQELNQLRVELDQTKQQAKQAELSAQESGKTNRKLKTEIQTLTDMSNRKDRQAENSKATAFFFEGQVKKYMDEIETARQGMGHLKELDDQLNQAKAEQAELEKTSKEEAVRVKAVIKSMQETHKANKENMKQEIEKAYAELEKASAQTLQLQQEIQQKMENELQSGMDIQALEKEHKLLEQKQIETIKQVYEEVEQLRKRLEQSEAYTLSHEENMLVAKEEMDRIVRRLRAIDQIANTKDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K768</accession>
    <name>A0A367K768_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CAT2_2</name>
        <name evidence="21" type="ORF">CU097_008682</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01000233">
        <property type="protein sequence ID" value="RCH97979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K768"/>
    <dbReference type="STRING" id="86630.A0A367K768"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="27"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH97979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="613" mass="69775" checksum="E365CC4A60DA3910" modified="2018-11-07" version="1">MPHTPKTPVDPNAPGPMLRFQNNLPKLPVPDLNETLPKYLKSIRPLLSDEEYKRSEQAVKEFLAPGSIGHELQKRLVARANDPSIVNWMEDWWLDQAYMGYRDPVVVYVSYFFAYKDDKLRRVPAQRAAAITTAALEFKKLIITKTLEPEYAKGEPMCMDSYKYMFNNCRIAHKPSDLKATFDPIKNTHIIAIRKNKFYFIDTVYNGQQLSTKEFEQQFQRVIDDAGDIKGIPVGVLTSENRDKWCDYRDDLLAANPNNKKIMEKIESASFVVCLDDLTPFTRDELVRACWHGDGRNRFFDKPLQFIVFDNGKAGFMGEHSCMDGTATCRLNEYVCDGLARNLVNHGSDHVRTDIPKPEQLQFVLNNKVEKAIETAEKDFDELIGNHEMTVLAYNAFGKNFIKKMKCSPDAFAQMAIQLAYYKMFGTSRPTYESAQTRKFQRGRTETCRSVSAESIAFVKTMEDPNASNQEKVAKLRAALKAHGQYMAQAVNAHGVDRHLFGLKNSLREGEQKPELFTDPAFAYSSHWYLSTSQLTSEHFDGYGWGQVVNDGFGVAYMIKNNALQFNVASVKDLEVHGKKYINGTHRFKQALEEACDDMRDALLAEAPAQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7B3</accession>
    <name>A0A367K7B3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000228">
        <property type="protein sequence ID" value="RCH98046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7B3"/>
    <dbReference type="STRING" id="86630.A0A367K7B3"/>
    <dbReference type="OrthoDB" id="96345at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="350" mass="40152" checksum="DA41AEDDDA8F3A8C" modified="2018-11-07" version="1">MMAPFTTPTPPSTKGKKPYKSWLKDGVNGGPSSMDVLVNWLSKKSNYAKWKGDDCERIPKKSLLESIIDEMREVGIYHRLAKDVASKISTLQANYRLAREWREVDGKKLLESGATEEAVHEELLKRFPYWDALHEVFSSNRTSAWPMSISSITHTEKQQQQQQQQTEEDEEDLFKLDDVTLKKRRRLSDSHVETSNNTSLANSPTHSTQSLPAISHPTNNNLTTPPFTSNNYKLTNSPPLVIRPLPRVLPPANHYFDPQPHHYNNTPLTPQPSRDALAESLIQVTREKEAGRMKRSQEMLQFLREKRLERDQLLLEREITKRVKAKADLVKHLIEAGFDKEAIAEQLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K877</accession>
    <name>A0A367K877_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000201">
        <property type="protein sequence ID" value="RCH98385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K877"/>
    <dbReference type="OrthoDB" id="2225991at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13643" checksum="4D182D1C03A0C467" modified="2018-11-07" version="1">MTSMNQDYVPIPQFPACFDGQWKNITKNPHLKTIMKFKAGTTLPPHHFPSKAHITVLKGSIQIDDLESSQAYILRESEDCTIPALLVHEMQFTEDVEFEFELENLNELVIYWDMEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8N6</accession>
    <name>A0A367K8N6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450-dit2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DIT2_4</name>
        <name evidence="9" type="ORF">CU097_004480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000215">
        <property type="protein sequence ID" value="RCH98201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8N6"/>
    <dbReference type="STRING" id="86630.A0A367K8N6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="527" mass="59578" checksum="524B9AE0C9DF0FB9" modified="2018-11-07" version="1">MELTEIAIETYHRALDKLVPILQKRSKRSYIGVAVALVVLERIYSFFKVPKSIRHIPAVSYFAMAKSLLTAEAPSSRYKRIVLPVIKKGNGFYVSKLPLEWTVHVATPMSAKHVLLKSEIYPKSESFLKLLGPQSPAVLFLGGSNVGFVNGHAWKKQRKIMNPAFHRSMPIQTMASVMPDFFSAIDKYGDDGTPISAVMRDFTLDVLGHTAFGFDFKALKGDPDYWTRTYHIINNALFNPSANMLTSLNPILSIISPERRRILEAIKKLNGMLEAMIKQKRQEVQNNAQAHVPENEKDLLTLMLEAQQRGEGLATDEELKHNVSGFFLAGHDTTSETLSFYFYNIAKNKDVQRKLREELNTVLGDKPVDVIPTLEQLKSMEYLNCTIKENLRLNGPADNILPRVATEDMVVDGTPIPKGTVVNVDIHAIHHDTRYWQDPYKFVPERFLPGGEHDSHSGMTWLPFGNGARQCLGMNFSLAEQRLVIAMTVRKYDIEVPKDSIHYDHPILESSSTKAPASLKLVFRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9B3</accession>
    <name>A0A367K9B3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000173">
        <property type="protein sequence ID" value="RCH98756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9B3"/>
    <dbReference type="STRING" id="86630.A0A367K9B3"/>
    <dbReference type="OrthoDB" id="2286498at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="190" mass="21294" checksum="8FC83D7BE74612DD" modified="2018-11-07" version="1">MSNNKNFIPTPPVENVLPLQVQNNSMYFSDNTEIMETDARSMATSELGDGESTDAIEALRLTLKNLTQKLARGVALNAPSDELTALQDEATRIKNCIFSPSSIANALFSSPSPDYQQPASRLSHLIPSDLPVWQWRGSEWKKDANIHNSVEDPLDSFALIAESNGLKLDKNWERLIPIKMNRDQRIIKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9P2</accession>
    <name>A0A367K9P2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MCM6_2</name>
        <name evidence="15" type="ORF">CU097_014011</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000157">
        <property type="protein sequence ID" value="RCH98962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9P2"/>
    <dbReference type="STRING" id="86630.A0A367K9P2"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="411"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="754"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH98962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="892" mass="100678" checksum="5CAB9F6B5E7C5ADB" modified="2018-11-07" version="1">MASSHMNTMLDTQALMSEINTPSHMEVDDAATPRPPAQVRRPGFTPDTVQKFVDETGLIVMKSFETFLKTYKDEQLTYMSESNSGWKGYPYMMQMENFITSLLDTVFVDFGHIERSDSTLASAISDQYYRFLPFLRRAVHNVVSEHFPKCFQPRDQDLVPDSALNREFNVAFYGLSDMNRVRQLKTDKIGRLISVSGTVTRTSEVRPELTYASFTCNECGKIVNNIEQEFRYTQPTMCPTITCYNRTNWTLNIEKSKFVDWQKIRIQENSNEIPTGSMPRSLDVIVRNEMVERAKAGDKCVFTGTLIVVPDVSAFRTPGTSVEAERDTTTRPSDGLGKEGVTGLRALGVRDLTYKLSFLACMVQPASQNKVNNINLHGEDVPEETIQDVYNTLTPEEVEKLHKMIRMGDKFYSKLVGSIAPSVFGHETVKKGILLQMLGGVHKVTPEGMHLRGDINVCIVGDPSTSKSQFLKYVCNVMPRAVYTSGKASSAAGLTASVIKDEETGEFSIEAGALMLADNGICAIDEFDKMDIKDQVAIHEAMEQQTISIAKAGIQASLNARTSILAAANPVGGRYNKKRTLRQNVNMSAPIMSRFDLFFVVLDECNEITDYNIGRHIVNNHRQKEDSMQAEFSTRDIQNYIRYARTFKPKLTKAAADKLAEYYRELRQGDAQGVGRNSYRITVRQLESMVRLSEAIARALCNEEITVAHVTEAYSLLQKSIIRVEEEDVNIDDALDDNEMNELLTSTEALRSMSLNETEEPSEEHRDVNMDQPKGPSGAFITSSGKISIPYEKFEEIKQMLAIKLHQVQEESDEEAGITQDKLIMWYLEQMENDLDEEALEFEVTVVKKVIKKLLKTGETLIAVRQDQDEDALEQFSEDNPLLMLHPNYVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9T7</accession>
    <name>A0A367K9T7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin-4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CUL4B</name>
        <name evidence="6" type="ORF">CU097_011743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000158">
        <property type="protein sequence ID" value="RCH98948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9T7"/>
    <dbReference type="STRING" id="86630.A0A367K9T7"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000055">
        <property type="entry name" value="Cullin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="407"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="753" mass="88297" checksum="BA14061ACD66EB52" modified="2018-11-07" version="1">MNFEEEHNSKRPRLDNVISQLPFSNILTTSTGHMKNHPTLSDRTITVHNLRLHKPQLSTEYEHNAWNSLKQAIKAIKRQECPQESLEILYQSCECLCQYDKAQELYDLLHMECLELVQNQCHELSRNLDSDEHDYLNKINTIWRNYCDQVSQIKSLFLYLDRTFSLNAKGGSIWAMSMDLLRSSFLEHEQIRQKMLSSILELIRMERMSEEIDVPLLQSIIRMLLDLNLYHTEFEPGLLVATREFYKAEGDSLISSQPMGDYLNHVSTRVHQESILRVKRYFDKSTKAPLQAIVEEELLTKRVTDILNRCFSYFHENYLVDELSLLYRLLKKVGQLDICAKYFINYVKTKGSSILCDRLPVQEKMNILSTFKKKNEYIVDHSFEGDKRFVDGLKDGTGYFINLKENNVVRLLAKHVDNVLKSEKFDEKQLDQCIFVFHHLQSKDVFEALYKKDLAKRLLLDTTNKSGEKVMLAKMKKECGAAYTSKLEGMIRDIKQSNEMMQEFNETVQLHIPLQLNVNVLTHGFWPSYTSVKVNLPHHLQQIEDIYTEFYMQKYPRRRLTWQNPLGVCEVHANYPKGPKRITLTLLQTVVLLLFNDKTRHYLSFTDILSSTSLDELELRRVLTSLLWNEYPLLRKEPIDQEIKPTDLFYFNDNFTCSSDSLKMITATLNEVIEKDAELDKTVLLSREQQIDAVIVRIMKSKKQLGHGLLLSEVTRQVRFPVTSQDIKKRIEVLIDKEYLERNTTDNSYTYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9Y2</accession>
    <name>A0A367K9Y2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000154">
        <property type="protein sequence ID" value="RCH98998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9Y2"/>
    <dbReference type="OrthoDB" id="2286768at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="241" mass="27969" checksum="81FA8AF1C5F72367" modified="2018-11-07" version="1">MFPINKFDEDKCITKLFNDKNDKAKITSFIYEGILMKRTKLEAVLFCKTSLTLRLDGDFDPTDEMDKCIKACCLHFKNNNYGIYINSEASFIKKHLLPFVDEMFLKSPDKNIICVMMDGAEQNGRMPDLKLGYKFKGKPHFAFFVEVKRPGQTSHYQDEIDFVKLLKAMKKPASFGLLVEGFKCILYMMKIHEEGVYIPAVVRKFVLIEGIENAVNIPAVVESFFFVKEKLDVFFRNFKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBA0</accession>
    <name>A0A367KBA0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SUPV3L1_2</name>
        <name evidence="13" type="ORF">CU097_008077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000117">
        <property type="protein sequence ID" value="RCH99523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBA0"/>
    <dbReference type="STRING" id="86630.A0A367KBA0"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="237"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH99523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="595" mass="66984" checksum="49591487D3DD5D18" modified="2018-11-07" version="1">MLRIIPLRQTSCLLLQIKLGASVAPLRHFHQTAPILRKGGLPRKGSIIDNAVWRILSPKRHRRIEEELLQCFLDYAKPFLPEDIVDKVNSLRKISDLRYPTEWYPLARQMQRKIILHVGPTNSGKTYQALQRLESAQSGIYCGPLRLLAHEIYDKMNTKGIPCNLVTGEEKRIVSPYAPLTSSTVEMAPLGRPMDVAVVDEIQLIADPFRGWAWTAAVLGLAAKEVHLCGEESAVPLIQRICESLNEELVVNKYQRLTPYKVSNRSLEGDLSRITKGDCVVAFSRRDIFNYKNKIEAITGLKCAVAYGGLPPETRALQAKAFNDPDSGFDVLVASDAVGMGLNLNIKRIIFSTTHKFNGAEMERISFPQLKQIAGRAGRFGTAYGNGIVTSLHPRDLSYIKAAVDSPIVPLETAGLQPTVEMLELFASQMPNQPFSSIIQKIEDFASVTGDYFMCNTKDKKAIADIIEDIPLEIRDRFQFATAPVSIRSEPSMALIKTLAKKFSRQETCRLEEIVELPEIPPINPEHLVDLEEKHKQIIVYMWLSVRYPEIFTTEQETAVEIKTRCEKLIDEGLKVSAANKKEHRKRSRAKYSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBI4</accession>
    <name>A0A367KBI4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000119">
        <property type="protein sequence ID" value="RCH99500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBI4"/>
    <dbReference type="STRING" id="86630.A0A367KBI4"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="567"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1048" mass="118260" checksum="DA42842C62CB7134" modified="2018-11-07" version="1">MVTTISSTSPSEANAEEHITLINYLNKVCKDNGDRIIAYYYSNNGFRSLTFAQVDRIATNLACKWSSIIKDTQTVSYLADHGIDYLIVFLALLKLRVTPFLISPRNSQAIIVHLMKTTQSKFLLASKKYQSIAMAISSSVKGMRELIMNPLQLDVLTMEPYYPDYQSILNHNYISSDITKTTLIMHSSGTTNFPKPIYCSNKYMFKAISFLSILQSSGHAMMPIDHNDVFLACAPMFHSFGITSAFQIITAGASIVYLEKLPPSQNEIAQALRSVQCTMMSAPPLILEQMLSAAHDDLEYRESLARLKYIFFGGAPLRFETGEKLHEYNINVRTIYGSTEFGTVMASNLDRSSKNWYALRPFIKDPNGEEYCLFETVDRDVKHMIIRGDYPNLATGLAQANGYGSNDLFKEHPDFPGYYIYINRLDNILIMENGEKTNPAPMEMAIANCSVVNQVIVLGHGRQCTAALVELHKEYMENGQQKDAVKMVYDAVEEANKECPNHSMLLKQMVKILPPGKTLPTTAKGSVSRKDAEEMYKDTIESMYKAFINGPQTQSTSPVSQSPEKVKEFLIDSVSATLNVPKASLQDTSCSLFSLGLTSLSAIQLRNLVASQYSHIPQDFVYQFSNIDAMCGALTTAKIINKPVQNEQQYEQTRMLTKAYIKRAEVDFPEVKGLCATKDSDLVILLTGTTGSLGSFLLCELLKSRKVKKVYCMVRGNSDIKRRQRMEEALLSRMLDASLLDDASRIELLPMDLNDPYLGLCQDRYLQLQWEIDMVQHCAWMLDFNRTVADYDKECVSPFYNLLKFAYRESNPMRVHFISSVSASANLGDLIEEAPLSLNPGATMPNGYAQSKFIVEVLLDYLVTKKKWPCFIERLGQVCGDTEHGVWNVSEQYPLMFIGGARMMKKMPRLDTVIDWIPVNYAAASISEIMLHTSTLQAFTDMSVYHVVNPNTIMWSDILSVMKEAGMVFDVVSPSEWVQELSDDMNNPAYRLLPFYKTNLTDSFKMPVWQTERTRKASPTLNKAPAVNPILFTKYLKYWEQKGFLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC71</accession>
    <name>A0A367KC71_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CHS7_4</name>
        <name evidence="14" type="ORF">CU097_014647</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000103">
        <property type="protein sequence ID" value="RCH99740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC71"/>
    <dbReference type="STRING" id="86630.A0A367KC71"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH99740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="324" mass="36744" checksum="FDECB7D0865C57C5" modified="2018-11-07" version="1">MSAITYSFEALNFNGICKTIAISLCPLIGQHNGIEPVCYSRNVELSGNIIFQPSTLIIDVVAIIMTMIMIYHIRSKYTAVGRQEIVMFFYLYMLTTLLDMLLVTGIIPTSSTAYPWFTAIHIGLGCATFWCLLLNGFVGFQFAEDGTPLSLWSIRISSFIWFLVTGFLAIGTFKGVAGLSYTNQAALWIFYIVLNYFMFFIYIISQIILVVNTLDDRWPLGDILFAAAFFAVGQVLMYVFSVVICDNTKHYVDGMFFGAICNLLTVMMIYKYWDSITKEDLEFSVGSKQNVWEVKELMTEDDHTPYTNTPPQPYYEPAPPAHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCN0</accession>
    <name>A0A367KCN0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein fam72a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM72A_2</name>
        <name evidence="2" type="ORF">CU097_014824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000086">
        <property type="protein sequence ID" value="RCI00003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCN0"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15892" checksum="B51B3769C9187BF3" modified="2018-11-07" version="1">MSAPFYLADIGEVIMEWHRVNDRGGIGQRPVYRVECGDCSTVLSDRCMRAALLSDKKTVIYSTDMRPTTVGYIYGDYSAPCCGCRLRDIACIACGKELGYNITFPCTKCLSSENNSHYWMFRECNVTSKQILFEGNIKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDI0</accession>
    <name>A0A367KDI0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase-activating ribosome biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RLP24_2</name>
        <name evidence="4" type="ORF">CU097_014276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000071">
        <property type="protein sequence ID" value="RCI00248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDI0"/>
    <dbReference type="STRING" id="86630.A0A367KDI0"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="3">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="159" mass="19114" checksum="298E208913D22EFA" modified="2018-11-07" version="1">MHITRCYFCSGPCYPGHGTMFVRNDSKTFRFCRSKCHKNFKMKRNPRKVRWTKAFRKASGKEMVIDSTFEFEKRRNVPVRYDRNLMATTIKAMKRVQEIRAKRERAFYKNRMAPNKEKEKAEDIRVVNQNIELAPLEHKKRVQAIKSEKEQTQTMDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDU5</accession>
    <name>A0A367KDU5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coth-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000063">
        <property type="protein sequence ID" value="RCI00394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDU5"/>
    <dbReference type="STRING" id="86630.A0A367KDU5"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712271" description="Coth-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65613" checksum="9626C8726F8C09F5" modified="2018-11-07" version="1">MLLSNILSTSIGLLLAVGIAAQQDQDYKVDYNVISLLNQTTFKSMAVVIDNISYPLEVNKTFPILYSGKGPSAQTGYHYAKVYNNDSLLLEPFVRQPVNQSTPHEFFNRSWNTHESKQLPQVYPPLDAIHRIHSNLHRDNEIPTIHITGNQTLIDQMNRNTSADISVPSNVSYLSLHDAFHFEDVEISLSGRSSRWMPKLSYNLKLKKKDDLYGYRRLKLRALYTDPSYIREKLAYDIIKSVGLVSSEFSYVRVLMNDQELGLFGIIDTFKNPWLANVFANGSSSYKNGYLYQGVLATPESSAQNHTSDLSYMNNITAYGDGQYKIKEEASKGKKENWEPLMKFTEFVAKAPTNSSDAVHKWNKELDTDSFLRSMALEVLLGYSDGYLTLADNYYLYQNPETDSFFYISSDLDLTIGSTIFKLDKMWSGNYSNFPQIYSRPVMKQILQVPEFKEKYNQLLQNITSELINPNVTVPFIDNIVDMIKEDVAWDQSLLRTGNNLIAGSFGNTQNNSDVTDVIGQLPLSFDMDTLIDFAKRMNETIPFETAVNGPTGHASLTGVKEWFNAVYQNTTRFYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDZ9</accession>
    <name>A0A367KDZ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein alpha-16 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPA1_5</name>
        <name evidence="13" type="ORF">CU097_015650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with goa-1, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisons, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000063">
        <property type="protein sequence ID" value="RCI00397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDZ9"/>
    <dbReference type="STRING" id="86630.A0A367KDZ9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="40574" checksum="0986FFAD6EB315D6" modified="2018-11-07" version="1">MGCCQSTEQVEEKQRNQEIDAQIKRDRVNMRKEIKMLLLGAGESGKSTILKQMKLIHDGGYTPEERESFKEVIFSNTLQSMRVTLEAMDNLGIPFRNPENELHKRLIMDAPPQIDYLGHELVEAISSLWDDLGVQECVSRANEYQLNDSAKYYFDSILRIGQPNYMPSDQDVLRSRVKSTGITETTFVIDSLTYRMFDVGGQRSERKKWIHCFENVTALMFLVAISEYDQVLFEDASVNRLQESLTLFDSICNSRWFIKTSIILFLNKIDLFQEKLPKSPLSNYFSDYKGGNNYDAACQYLLEKFVCLNTRADTKQIYTHLTCATDTKQIKFVMNAVNDIVVHDNLRNVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEP0</accession>
    <name>A0A367KEP0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000044">
        <property type="protein sequence ID" value="RCI00713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEP0"/>
    <dbReference type="STRING" id="86630.A0A367KEP0"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="111"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="335"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57524" checksum="DC9A40652F04E581" modified="2018-11-07" version="1">MSFSSLEERPNMANNLWRQSSMRSATSSIITSSSGGEDSFQSLETLSTDLTLPYNQSIDQLSILQDGSAHYYQLIDDLAIIDDLYQSFQPDEIEEDIYERQVADVARNVAQKKHDVDQIYQLESQFVQDLTVFHQVYLVHLQRWIHEPSNADLFNKNTCHRAVLTNLFDHILKLLSVHQHFLNSCKERLNMWGPTQFISDIFGSLYEKISVYEPYLELIPNVVVSLDTLYSKSSSFLKFLESCAAKTDRQVKDIIYYIKRPIQRLSMYVSTLSHIISVTEPSHPDYKALIRIRDKFNSQDKQWRALIKDRLAHIRALEAARSMIGSPVSVSVTRRLYITGLLTKVDLSDAQSMSDTRTYLLYSDYFIYGQKIKPTIGKKSQPQKLQYKGVINLRNAELKPLSEQVVAKISESKKTSVLTAAFKRNKQTEPQPIVYVYGFQLKIDQALSDNAAGTILPGTVISNGVVTPHISTSKQQFIFRTSTEAEQNAWMSMLKKAISNVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFA4</accession>
    <name>A0A367KFA4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000035">
        <property type="protein sequence ID" value="RCI00896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFA4"/>
    <dbReference type="OrthoDB" id="2282250at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="16198" checksum="4E8B7ECC7E7D3BDB" modified="2018-11-07" version="1">MLSKQSIDNHDTKALDPLVAFAHFLISCQQRIISIDRWDDLTVTKLYLVAMEMVKNDSKTENDKVEALQTICQATQNASLKRKCDTMEQGSNNAPSEVTIPMVLPKDFDGTSTRSINSKYKNLIAFIDAWKQNNKGRMNWPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGI8</accession>
    <name>A0A367KGI8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_012324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000031">
        <property type="protein sequence ID" value="RCI00962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGI8"/>
    <dbReference type="STRING" id="86630.A0A367KGI8"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041120">
        <property type="entry name" value="RqcH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="9">
        <location>
            <begin position="504"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="10">
        <location>
            <begin position="953"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI00962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119909" checksum="45423D640D88D2D7" modified="2018-11-07" version="1">MKQRFNALDIRSTVMNLKERLIGIRLQNVYDVNAKTFLFKFAKPDDKELVLVESGTRIHTTQFSREKSDMPSPFCAKLRKCLRTRRLTNVRQLGVDRIVDFEFAGGEKSLGYHIICEFYASGNIILTDHEYRILALLRTVQPTETLKMAVGEIYNIKSVLADFTKVDSDQLKEALSAAGPKDNLKKILNIKFEYGPAMVEHIIMESELDPNMKVASDFDTSENSPMMHALLEGFKKADDMIQSTKNAVPRGYIILMDDKRPSDDKEDAIEIYDEFHPFLYKQFTHRKFKEYPTFDMAVDEFFSSIEAQKLELKTRKQEEAALKKLEAVKQEQEKRVESLLNQQLTNTRKAELIELNLQYVDAAITIIRNAVASQMDWQDLNDLVKEEKRRGNPIALLIDTLKLDTNQITLVLTDPDYHEESEDEDEKEKPKETFKVDVDIGLTAFANARKYYEQKKSTASKHEKTIVASTKALKSAERKIRQDLKETKITATISKIRKPFWFEKFMWFISTEGYLVIAGRDMQQNEMLVKRYLSKDDVYVHADLHGAASVVVKNKPQANGQPISPSTLYQAGIMSVCQSKAWDSKVVTSAYWVYPDQVSKSAPTGEYLTTGSFMIRGKKNFLPPVQLVYGFGYLFKLDESSIGNHVKPAKENDLSTEYDDDVLKPEQPAKIDSIEEIDKSDVAEKSKEAEPNASSGISISNSEKSVNEEDSSSDDDDSDDSSSSSSDDESAFPDTKLQSLPVSNHENIPDASKYALDEYGHDSDEDQTSSAPDSDKAQAKKRFITAKERRLMKKQNATEITEEIRLKQQKQQQKQQNNGKQKQQAPAKPSVTTPPSSTRGRKGKAKKIKEKYADQDEEERQLRMELLGSNKGPQPKGKKAKREAKAKAEKAALEKERARKEAEEKARLAQSQKEEEEKENDGSLEVGEEKDSDVIRQLLKEENITMLEADEIANLSALDSLTGNPLPEDILHFAIPVCAPYPAIQKYKYKVKLTPGSLKRGKAVKQAQSVFLALSDASAREKELIKGVADMENINTMMSKVKVSAPNLETSKRKKGSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH46</accession>
    <name>A0A367KH46_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000009">
        <property type="protein sequence ID" value="RCI01461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH46"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="86" mass="9468" checksum="02ACD0192393CECD" modified="2018-11-07" version="1">MSIPTRNAIYTSPNIPPMAATPYAATPYTTPFIPTQQAGYYPPMGSMHIGGPPPPMMIQQQQPIFLPRREPCDCCYNDCTGCCLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJQ2</accession>
    <name>A0A367IJQ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005573">
        <property type="protein sequence ID" value="RCH77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJQ2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="8561" checksum="095E92B10F5FDC9E" modified="2018-11-07" version="1" fragment="single">KTSGSNSSSPNKPYMSSYNPSIPPLQDSIASSLPPFSRTPADSFHIPTPNVLPPLTTNANGFNNVTNNNSNADNNSSRQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK57</accession>
    <name>A0A367IK57_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005458">
        <property type="protein sequence ID" value="RCH78050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK57"/>
    <dbReference type="STRING" id="86630.A0A367IK57"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16883" checksum="06119F591ACC9099" modified="2018-11-07" version="1" fragment="single">SLFRNNNNSEQRKSNRSQSTILTDYQLLSTHSAPTTPRKLSPQSSISSRIRHTWHVDRATVKQLLSHTPDLFSTLSAYTHKISNKERRGMAIWRSTYAAYIVEPPPSLRFKPKPVTKRSIQLSKFIMAELLTTEETYLNHLMTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN70</accession>
    <name>A0A367IN70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004719">
        <property type="protein sequence ID" value="RCH79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN70"/>
    <dbReference type="STRING" id="86630.A0A367IN70"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="29444" checksum="111B8D48E46CEB7F" modified="2018-11-07" version="1" fragment="single">MKAIIVDKWLKGPEDLVIKNVDLPPEPKKGELQIQVKAAGLNFFDILMIQGKYQIKPPFPFVPGGEFAGIVLKSTVPQFKTGDRVFGSGNSFAEVVNVSASSVLPIPKNFSFEEAAGLYITYPTSYSALVLRANLKAGEYCLVHAAAGGVGIAAVQIAKALGAKVIATAGTSEKLEIAKKFGADYAINYRDKDWPEQVKKITNGHGADVVYDPVGLVETSTKCTAWNGRILIIGFAQGTIEKLPTNRLLLKNISAVGLHWGAYTKNEPERIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INK2</accession>
    <name>A0A367INK2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004622">
        <property type="protein sequence ID" value="RCH79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INK2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="13743" checksum="135D72E5D9D8D78B" modified="2018-11-07" version="1" fragment="single">MDDINTLLEQTGLSSIQSSGLAIISIFGVSDNTTQASPAILANRIVGSAVFSHRKESIKEGTIELVKGGLQLYVDLKANTVYLFLDSAIDTSILGNQHEQLNIAYSYGLSVYQHEEFIVHDDRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISB2</accession>
    <name>A0A367ISB2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_001851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003838">
        <property type="protein sequence ID" value="RCH80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISB2"/>
    <dbReference type="STRING" id="86630.A0A367ISB2"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016858878" evidence="14">
        <location>
            <begin position="33"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="309" mass="33279" checksum="D7797291AF2C1FDC" modified="2018-11-07" version="1">MTTIGLYSTMVQFLYSSLTILAALLLATSASGQKVCVAQNSKTDDTITIIQAFNDCKAGGTVSLPKEKTYNIKSLIKVTSLKNVKIDFAGKIILPLYDPKFKGGSAYLEISGDNVHLSGGGTIVGNGQSCNFKILNAHRGHIAITGAENVIFENVYLNTRSTGKNFARNTDASGVTSSKNIIFRNSQLTVGDDCTAINAAVTNVTVTGIKCYEGHGFNIGSLGHGQRFDFVSNIYFTNNECHSCQNGVRIKTVSGEKGAVSDVRFQNVQLYDTVNPVAITTHYFCEQNKNCNNDQSLTISNVVIDRITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISE6</accession>
    <name>A0A367ISE6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003928">
        <property type="protein sequence ID" value="RCH80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISE6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9268" checksum="D147048108AFFC42" modified="2018-11-07" version="1" fragment="single">DEIDHLLSKDCPNEIPVFGMLIRDYQTVGEIQSLFYRNHEVAAPTTKTNRPQTLSPLNPVSSPYNTISIAITTRDSTSTAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISU6</accession>
    <name>A0A367ISU6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_003044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003749">
        <property type="protein sequence ID" value="RCH80764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISU6"/>
    <dbReference type="STRING" id="86630.A0A367ISU6"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_uL4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH80764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="267" mass="29741" checksum="5AFB5ABBFC55091A" modified="2018-11-07" version="1">MSLFNTFSRATARALPTIQNRAFASVAETTAPKGMFMNNACSYESTNSFKSTAFSTPLQAFLREFKTNEPISIINLEKDVFGAPIRRDILHRVVVWQRDAMRQGTHSTKTRGEVAGTGKKAAPQKGRGKARVGDRKAPQFRSGGIAFGPKPRDHSTDLPRKVQDLGLRVALSAKYAQDQLIVVDSLQHVESHKTRDLAQILQNAYDGSKMLIVTDDCNEKLELAARNLPNCEVIHVEETNVLDLLTYDKLLIEKSAVKLLEDYLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVU1</accession>
    <name>A0A367IVU1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003259">
        <property type="protein sequence ID" value="RCH81835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVU1"/>
    <dbReference type="OrthoDB" id="5568181at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="120" mass="13491" checksum="2B3B13CC0BB388A2" modified="2018-11-07" version="1" fragment="single">FYHYTDKASTATLPKLMIHPYIPTTTEQETNILSVLLRTKLIPDIEKLEAETQAAIARELVDPQANHNTRMDDEQLIKDQLDQWTALRDRHDRLAADAAHSGKSEVVGSDLKKLASAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWF8</accession>
    <name>A0A367IWF8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003213">
        <property type="protein sequence ID" value="RCH81949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWF8"/>
    <dbReference type="OrthoDB" id="2324139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016918449" evidence="1">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="262" mass="29529" checksum="4F0128B0B95B0EAC" modified="2018-11-07" version="1">MLVKTIALFLTLTSAALACEMDCRRGVSGDFADVYKPIIDMSVNRLQTQLTSSIPKVSVPSKITTHVSNEELVDDIRASIKSTLEQFANTELSKPRLAEGFYQVIFNEENPYKGDCNNPKRLTRKMPPKGESWTLEECEKMDYRCGNPPSICHFLDDVKERCIGRIRRQVGEYASFDNGVLVKNLAKDTRRSIHRTLAKHGVGQLSEDKAVSTYVTKVVASIVGTLDQWIEKDVGQLCEGPDQEEICNSWNDDIKKKILVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWZ0</accession>
    <name>A0A367IWZ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003108">
        <property type="protein sequence ID" value="RCH82198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWZ0"/>
    <dbReference type="STRING" id="86630.A0A367IWZ0"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="52" mass="5622" checksum="7ACB39492AB3F183" modified="2018-11-07" version="1" fragment="single">MAGGCLGQLGQVPLNAHEIFVLRPALERDGYVPSFAGISTFAHLPHVSCWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXV5</accession>
    <name>A0A367IXV5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002989">
        <property type="protein sequence ID" value="RCH82508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXV5"/>
    <dbReference type="STRING" id="86630.A0A367IXV5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="36065" checksum="25C3AC7AD0140B90" modified="2018-11-07" version="1" fragment="single">MSVAGSTSSHGTHSRSPSRSRSPPPYNEGRYSSRYRYDYNYRSNRSMSAALDDYRDLRDRERDRERMLRDDRYLPPRRDRDYRYAPYYREDMHYPPPPHSYPKPSPGSLRRDEPKDKLPSGSNSTLKDTKDDKPIPSTSSEPYNRYMDWRERRYRDDERRRGYDRRYMRYESSGYGMPPFGNDSYRGDRDLLPSPGIPYYERDRLDDRDYYRRPPPSDYDRYRPSSGNMNGRGGTGRPSWRPQPDDRRPLDREREREKPYSTFNNRMNDPNRPQPAMQHPQAPSSVELQSQPQPSQQLEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ22</accession>
    <name>A0A367IZ22_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002875">
        <property type="protein sequence ID" value="RCH82839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ22"/>
    <dbReference type="STRING" id="86630.A0A367IZ22"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="219" mass="25815" checksum="236474F0F50AAC55" modified="2018-11-07" version="1">MNRIKFVPICDWPFLLNQAEPVIEERMSEVKCKSIFSKWIQSANDSKFLERPKNMQLFFNDDQKLEGIRFIMNNGSSEDFIEFGGNLQYIAPELYLHHEYHADSVDVWSLGITLYRLLVGRYPFNSDSMGDKALFERMLQFRYPIPNSLSPEAKNLIQQMLSPVESRISLSRLSNHPWFTLNRRKKKSVRVLKKIIRFIIKGPYPPPKNPYFQLIKVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0I2</accession>
    <name>A0A367J0I2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HECTD2_1</name>
        <name evidence="9" type="ORF">CU097_003974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002655">
        <property type="protein sequence ID" value="RCH83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0I2"/>
    <dbReference type="STRING" id="86630.A0A367J0I2"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="325"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="654" mass="75470" checksum="D7F573544C4095B6" modified="2018-11-07" version="1">MTVHFGSAFNLITQHVSHSLIDYLDLKIVQQLIEEVEWSSVSVYLSEVFSNQDYVSASFQQKKPSLKERCPIDKVEARKSFELLSAQWALWITTISERSKRLIQSMTRSSQENISADALNIIVILFQCREFIDVNSTKHLLQEICGFIIKLSKEEQDRLFRYLIEPTPEDQDDLSQFRHVLQIFQSFLSKRLQLRTGNSGGVYPDVSVIDATKCIAVLYSLNEQQRLVSYTEFYNETVNEQIEIKEDFPNYKDKKGFSFCDYPFLLNPAVKADVLKVESVYQMRHELQDAFFRALFQGVNSPYLVLEIRRDYIIADTLLQLEEKSIHDLKKQLRVQFVGEEGVDEGGVQKEFFQLIVREIFDPKYGLFNYNEESRLCWFSHNPVLDNVNVREYKLIGLLLGLAVYNSVILDLHFPLALYKKLMNVDVGLSDLKQLDPTLGKGLEMLLQYDGDIEAEYDRSFQVSVESFGHVFTYDLKPNGAEIQLTKDNRIEFVELYTKFILDVSVKKQFEAFKEGFMLVCQDSAIKIFRPEEVEQLICGCSDLDFEALEKSTVYDGGWTKDSDIIKYFWEIAHSFSYEEKKKLLFFATGSDRAPIGGLSKLQFVIAKNGGDSDRLPTSHTCYNVLLLCEYSSKEKLKERLLTSISNAEGFGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2P3</accession>
    <name>A0A367J2P3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_006643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01002431">
        <property type="protein sequence ID" value="RCH84208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2P3"/>
    <dbReference type="STRING" id="86630.A0A367J2P3"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="47"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="194"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="588" mass="68332" checksum="C3B7FD6B3202D352" modified="2018-11-07" version="1">MAIKNVDKVTLDNKQELSHIHQYSIFDTDDVLPSVLPIYKELEQVDFYIHHWEIKEWSNLDQRTHGPVFEVAGYKWRTLLFPKGNGQHEMASIYLEVVQNQDQKKDWAICGQFAIVISDPSNPKHFFSNHAHHRFCNEEVDWGFTRYYPLKTLNSFLKNDQVTISIFLRIVKDETGVLWHNLINYDSRKETGYVGIRNQGATCYMNSLIQSLYFTNIFRKAVYKIPTEKEDPNNSVVLALQRCFYNLQFADESVGTTELTKSFGWDSSDAFMQHDVQEFSRVLQDNLELKMKGTLVDGAVTNIFMGKMKSFIKCIHVDYESSRVEDFYDIQLDVKGCKNVDESFKKYVALETLDGENKYMAEGHGLQDACKGVSFEKFPPVLHLQLKRFEYDMQRDTMVKINDRYVFPDTMDLREYCSAPSNDPGEHIYVLHGVLVHSGDIDGGHYFALLKPQKDSKWFRFDDDRVTPVTLREVFEDNYGDDDHDDEIRCTSAKALKKFTNAYMLVYFQKNKLDEILEPIEENEIPKHLNKSIKDNARALKDDVINTLLQQQRNPKKDIRLKKTGSQPNNTTSDKKCNTVVSTRCCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3B6</accession>
    <name>A0A367J3B6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002427">
        <property type="protein sequence ID" value="RCH84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3B6"/>
    <dbReference type="STRING" id="86630.A0A367J3B6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="23884" checksum="F2ADD00E44CB0CB3" modified="2018-11-07" version="1" fragment="single">MSETIDDPLLRGASYLTGTAFISKYFVDHSLGHSLVLDYTTNEPKNGVLLIRVCEARGISPPANITLPSVPPQPVHQNRNRDSLTRKQNWWLPYVVLEFDKNEILIDALGGDTANPIYQHRANFDVSRSSEVSISIYMRHPPTQGESTSRTTNDFFLGGVKIQPNFGSTKIEDQVLNIVGGTGMMHIQLCYRPQQVRYELDNLMFILTYLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4E5</accession>
    <name>A0A367J4E5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Exopolygalacturonase rpg16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_006443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002266">
        <property type="protein sequence ID" value="RCH84793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4E5"/>
    <dbReference type="STRING" id="86630.A0A367J4E5"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016586574" description="Exopolygalacturonase rpg16" evidence="11">
        <location>
            <begin position="27"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH84793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="39950" checksum="8C4088F2ECBA39B7" modified="2018-11-07" version="1">MVQLLSLSSTIATFLLLSLGINDVAAAKTCVVAKAGNDDTAAILKAFNDCKTGGIVSFPKGKSYNLNGMIELSGLKDVTIDFQGQIVLPGWDKKYKGGNAYISIKGSNIHMSGGGTIVGNGQGWYDRQDHTAPTVIRFGATNSVFGNFKIINAPRAHMGVTGSNNIVLENIYLNTASSSKNPPKNTDALDISSSSNVVFRNSELNVGDDCTAINGGVTNVTLSHIKCNGGHGFSVGSLGKGGKQESVKLVRVLDSVCTNCQNGVRIKTWPGGKGVVQDVVYKNVQLNNVENPVIVTTHYCDKNQMSFCTKNNDSSLSISKVTFDTITGSVAGKKPAINIDCSKNTPCSGFTLSNINIKSNGAKNVCNNLSGSNKISYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J526</accession>
    <name>A0A367J526_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002224">
        <property type="protein sequence ID" value="RCH84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J526"/>
    <dbReference type="STRING" id="86630.A0A367J526"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="456" mass="51765" checksum="CA0CF68891EE68F8" modified="2018-11-07" version="1">MGGTVSKDEFGEQKHKRKLYSLKPQKSHKERSIASQHTIMSNATDENSSNYISRNSGSSGHVHNNNNSITIKVTPVKHQTVLSDHVSPISSLSNSAPIRRSSWRKSTVTTNDNLSAASLASCFDEDNNEVISSPRTSIASDDLLDDKRKKKKKLPGLASDIVLDSTRFTQNSLLDDKFWKTPIKSYVAYNKNDEKEYDRQLRQHYVLKHILHGNIHVPVSRDKSIIILDSACGAGFWTLDMALEYPNATIIGLDTFPDRSETISTLIGAPNVVYKYGDLTTRLQLPDNSIDVIFQRDTSTVLPHDCWPSLMSELKRIAKPGAYIEFMEYNFDVRNPGPVLELVNEWYKIASSSVGVHPSEVKRLKDFMIKAGFVDVQEKIIKIPIGEWPEDEAQRENGFLYKQVIKALFKSMKAWWVSELNVLENEYDKVTYAALNEFDEQKCSIEWVIYTARKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J573</accession>
    <name>A0A367J573_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitotic spindle-associated MMXD complex subunit MIP18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM96B</name>
        <name evidence="4" type="ORF">CU097_003017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002186">
        <property type="protein sequence ID" value="RCH85088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J573"/>
    <dbReference type="STRING" id="86630.A0A367J573"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH85088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="18874" checksum="9CA82215CD515206" modified="2018-11-07" version="1">MAQNLINANPTIYNTKNIVRKETEAEYDDNIEDPIDSQEIFDLIRSISDPEHPLTLEQLNVTQFEHIEVDNENNKVLIEFTPTIPHCSMATLIGLCIRVRLLRSLPDRFKVDIKVRKGTHQSEGAVNKQLNDKERVAAALENNHLLEVVNQCLSTASLRGMEIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6I8</accession>
    <name>A0A367J6I8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002095">
        <property type="protein sequence ID" value="RCH85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6I8"/>
    <dbReference type="STRING" id="86630.A0A367J6I8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="19746" checksum="09CA4A12DE273524" modified="2018-11-07" version="1">MKSACTLPSLSDIVNTNDYFYTRQSTKPSILHVSSLLSPIRTDSVLYESDEPVKAKRKRASPSQLYILNRVFQQTCFPSTELRIELGKRLGMSPRTVQIWFQNKRQSTRTRERVTPQQQRRSMFVSPPVSPLPSPSLIKSLSLPPLHPPPAFALSPSSSAHSSPTSIDAMLFRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J848</accession>
    <name>A0A367J848_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NuA3 HAT complex component nto1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NTO1_1</name>
        <name evidence="14" type="ORF">CU097_003385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001985">
        <property type="protein sequence ID" value="RCH85911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J848"/>
    <dbReference type="STRING" id="86630.A0A367J848"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="277"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="590"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="823"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH85911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1200" mass="136885" checksum="717D4CD77673FE4E" modified="2018-11-07" version="1">MTSNKGRRGRPKRTNGTIQGPISSTTTTTTTNDPLPTTAVQARFLDLDIKQPLMIKEPEDIHEEEPHSPIFVTPPRTFEDDFEEQEEAAADKEKPNEQQQKKDHSTQEIDYTRLPQVHFTISELDESHERGDPLISWTYQRPNHYIHYSEPSELELFDTVEYDMDEVDKVWLDLYNQEKRKEHKMDISSYMFESIMDRLEKEWFNLIKTIPKPVVEDVILPEDSACAVCDDTEVENSNAIVFCDGCNVAVHQDCYGIPYIPEGQWLCRKCQISPDAPVSCIFCPNQGGAFKQTTDGQWAHLLCAIWIPEVRLKNTVYMEPIDYSDIPKSRWRLTCILCRKRGPCIQCSRKQCYSAFHVTCAKAAGLSMKMKLQTAEHEGIVLVAYCDKHTLKETEENPSDDDEYVENQIVTTVQRGRGRGRGRGRGRPSGRTSARSSLDGMITKANRIHQHHYFTGAPIPPDMILSRIDMIPCLLTSPIRKKSQLVTAIAHYWSLKREARRGAPLLKRLQLEPWSPSNITARVIDEDTIVAKISFINELRANLDKARMLTEQVQRRERLKLERTKRQKEYLDMILYPIEHLARPILDQLIEIDANDFFMNPVTSEEAPDYASIIDKPMYFSKIQSKLNAHEYTRLDEFKADVELIWENCMTYNTPSSKYYRVACKLKKAANELFEVADKKMESYDLDNGILNAPIDESIFDYEAGDEAEIRIEGTLADIAATVPVRSRARPQLPMITTTTTTKELEDMARKVPSRRSGRGRTKNVETENYIIRESITQNEADIVRPTVPSQGLDKGVQTDTYLLLSLLKQFQSAEEIQKLEAQMDEDKNKQDTAPEVELSAPTVVEAEPAVIAKAQNVPSMPQEDKKEDTVTDNPSLQDITEGKEQQTPQDIIKDKPAESALEVIDVIGTDIPAHPQQTHKELEDRSICKPAEVHPMHKHPTDSTSSLYQQQQQHQQQQNKKRPRRSLSTAVPVRATRSRGLESTVEELKNRKRMSHEARELFASVLHLEKQVEKVKPYSSKPAAVGWAYLESDDEEGHKSGEEQVEETIEPIKKSSKKRKIEPVSLDEFERGQIVWARVSGYPSHPAKLWKVPDKGSKLVIPKTTANVLVEFLQVPPNHKWGWIHPKDIARFGDTETDKIKLAECLRIKASNRTVRMQEAKDGYLCACSELGKEDGQAVLDSVFNEVNLASHHKKKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC76</accession>
    <name>A0A367JC76_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_003813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001636">
        <property type="protein sequence ID" value="RCH87538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC76"/>
    <dbReference type="STRING" id="86630.A0A367JC76"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH87538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="309" mass="35303" checksum="2F54777D95FD5A63" modified="2018-11-07" version="1">MSASSSVADVDAWISQLQDCKQLSENDIKKLCDKAREILSQESNVQPVNCPVTVCGDIHGQFHDLQELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVCLKVRYKDRVTILRGNHESRQITQVYGFYDECLRKYGNANVWKMFTDLFDFLPLTALIEDQIFCLHGGLSPSIDTLDQIRSLDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISETFNHNNGLTLVARAHQLVMEGYNWGHDRNVVTIFSAPNYCYRCGNQAAIMEIDEHMKYTFLQFDPAPRKGEPHVTRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCL7</accession>
    <name>A0A367JCL7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001619">
        <property type="protein sequence ID" value="RCH87625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCL7"/>
    <dbReference type="OrthoDB" id="2441661at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24344" checksum="71306D50C04D2B40" modified="2018-11-07" version="1">MARLKIRDQVAEIALSANTEEHFKQTLKKYREYFSLDGRCTDGGVHGIQYLEKMLKEKEHWVGLYANNYIHLNSRSSNRAESTHSSQKRFIQASSGKLDLVTRKLDYWAKERLSLRKLKNEQESLKQSVRLISPEHEYKLGNSKGKVSKYAIDIIKQEMIASISNNCEYSDNCLCQVKGNFSLPCRHLLAKYDIIPLNILHRCWLNYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCV7</accession>
    <name>A0A367JCV7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TFB2_1</name>
        <name evidence="11" type="ORF">CU097_004796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001593">
        <property type="protein sequence ID" value="RCH87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCV7"/>
    <dbReference type="STRING" id="86630.A0A367JCV7"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="397"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="470" mass="53974" checksum="D27F845D208E53E5" modified="2018-11-07" version="1">MSMSVDNFKTSIYEYLETLPTITFMRLFEKPATCLAIFRLLPSVGRHLVMSLLYVQMPISISDIHSWVNREGEKKLVEALQKLASLRIIEQKDQVLIMNDTFRRQFQNALTGGGTQQSFGLPCPTPDKHPVDINFLDHYATTQWEAILHYMVGTSLTKKPSRGVLNLLERSKLMQESSDNGGQLQITNKGFQFLLQDVNTQVWAFLLQYLDMAEVLQMDLVEVLNFFFQLGSLELGENYSVDTLTQTQLQMLEDLRDYGIVYQRKKHSKRYYPTRLATTLTSGKSALAAATVKYNHLAQTNVDQTADGGDDQGFIILETNYKLYAYTDSPLQIAVLNLFVQLHARFKNMVTGVITRDSIRNALMKGITAEQIIYYLQSHAHPQMRKKTPVLPLTVVDQIRLWEMERNRLKPTASYLYHEFNMQADFDAAEKYARDLGVLLWSNNQKRTMAISEAGHENVKGFVKRRLQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD10</accession>
    <name>A0A367JD10_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-5' RNA ligase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001597">
        <property type="protein sequence ID" value="RCH87749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD10"/>
    <dbReference type="OrthoDB" id="2110229at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="23249" checksum="A4BD16A8BDA5DBAD" modified="2018-11-07" version="1">MLIDLIVYLEPPSEIKQQVDHFLDTTADSIDFTTANKYRCHVSMTGFFQTDHDQMDTVKEILDKVLQHDFKDNPKLDWNPLIVKDKLTSDPYHVLLPVSVSDGYRQCMQAFAKEARSKLDITVRPKRIDHISLAYWDEHEKKDCRELFEKIKEAADAYFNQVGCNGPWSIVLYQRSFRGDGLREPHIFKEISRWNVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD75</accession>
    <name>A0A367JD75_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_000888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001572">
        <property type="protein sequence ID" value="RCH87884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD75"/>
    <dbReference type="STRING" id="86630.A0A367JD75"/>
    <dbReference type="OrthoDB" id="4139168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH87884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="88475" checksum="170873674C6AACB3" modified="2018-11-07" version="1" fragment="single">QAPQALSISKQNILVSVPSEPIPSQVNWITGNLYNYALIQKRRIELIENFHKQCAITHLQWNKKGNTFASIDETGQLALWQIQGPVDKLLYNTHLKQPLAAFHWLDAEREYVSDQDKLVRESMNCLKNPFGHLGFITITVHGEITVHYQRNGAIFSSFSAHIPSTGRRDIRRSDASCYSMSLSGIDDWQRISHAAITSIDNTIYLATHSVSCQTKEIQLYSLDIKFPTVDKKGAIRRKRIANVCLLEKAHVTQMAFKTGVNLELYLGLGGRVDNTLERCITKYTTIEKSDQTFKSYIQHWELSTVDQSLNLSIGTISAKHATLSLTSETPIDDKFITCLKCTQDGNLVVGLSDGSIHLEISNHGLLKSNETPSFDSRFWCVVQPKKDTISDIVFSVNETHIVYMYASGKMGVARITNDALNEQQVKHLRLKLVQCLLNNTDSTDLISEVVRISKVSKTDISLEIMQDVLRMYEQHHEGDEEWSLGALQKGYGLALATFNEFPTKHVQSTNLSRAVQLPIILDSFIASCTSNYEDIEKALSKETSVHLEFDPNSLWSLVILTTWIFDFLKWILHEWNILLHSEKHPISEEMMYQKPVHAVLFLHKESRDYLKKILTFIPHFITFASSATYQLDHLPESQALLQQYTDNLQKEPPVAINQVIDLLNDLNHLEANTKVSNRWSLLLTSTLQGYSIPKLQQVSLKYKDKCVKPCIYIEKEILAKYDPIRKRSLGDHVKTHLCIRCHQHILPVHTESDLLDPSSSASWYQSLGRRCVCGGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDC9</accession>
    <name>A0A367JDC9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH kinase pos5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">POS5</name>
        <name evidence="8" type="ORF">CU097_002938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001564">
        <property type="protein sequence ID" value="RCH87927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDC9"/>
    <dbReference type="STRING" id="86630.A0A367JDC9"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="42755" checksum="BB3ABFF8DAD6CE42" modified="2018-11-07" version="1">MRLLPLRTCLLKRQVSFQRFYHVLPNKVGIQLTRDQQELTEAEHDLMKTSRSPNDILQVPGSTYGGLYTLKWAEKPNNILIVKKPQDDKTARAMIELANWLHQTRPDMNIIVERYAAEQFRKELPFVHVIDQNEYTRTVDFAITLGGDGTLLHLSSLFPKAVPPVVSFSLGTLCFLMSYRFDRYQDILGNMISGHNIGLNMRMRLFCSLHQSNGKRIQVDGKEVRDRQVMNEVTLHRGRYPHLAAVHCLVDDQYLTECIADGLIVSTPTGSTAYSLSAGGPIVHPSVQSLVLTPICPRSLSFRTVLLPSSSIIQLKIGENTKNPIEVSMDGQEIFMLNKGEYVKVRMSKYPIPCVQGARWEKDINELLKWNQTFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDV4</accession>
    <name>A0A367JDV4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adhesion regulating molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ADRM1</name>
        <name evidence="9" type="ORF">CU097_010666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001532">
        <property type="protein sequence ID" value="RCH88087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDV4"/>
    <dbReference type="STRING" id="86630.A0A367JDV4"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="268"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="211"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="378" mass="42074" checksum="8908375295D59712" modified="2018-11-07" version="1">MSLFQTAPVRRYLVEFNAGKCIIEGNLIKPDLRKGTIYMDQSDDQLLHFYWKERNSHAEPEDDIIIFPSEAKFVRVSQCTTGRVYMLKFNSSREKHFYWMQDKSEEKDDENANSVNEFIESPESMSADLDDSTSHAEIMRLLSGAESQDANITEENILEFLNSISRSRQRSRNEPRVRGTSTLREEVSRPVAEQQQQEQEQEHEPEREPEPTVAAPTSVDTPTATPAATATTTTTTTTDSAATANNASTGNNPDYAQLAQMLASMSGQRGPVQSLALTDILNSQTLTPLLNDPEVCESLVPYLPEESEKTAEEVRQVVRSPQFSQAVQSLTVALQTGQLGPLLSQLGLDPSAGYSVELFLNAIEKQAQEKSSNAMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE71</accession>
    <name>A0A367JE71_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_009250</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001507">
        <property type="protein sequence ID" value="RCH88224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE71"/>
    <dbReference type="STRING" id="86630.A0A367JE71"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="632"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH88224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="691" mass="79112" checksum="CDBA6170DE1228EB" modified="2018-11-07" version="1">MEGGGEQENEQSRFIPRQQMNRTSFYLLLFLFSLLFFSFTDDGLMKEGKPTKEEVIQDLQNEKEMLGNMTFGVNITHPLPLSVSSSLDELWSVHDPHSSHYYHNITGIFRGEWKNRNISIPDTANMTEIDEARSKFKFDGPATFTLQLKSFSTELEDANYIEGYIRIRDAEKSDSGVLLMTGGVHFLNNGSLYLMAVPNGLSIPLEDLLNMLQSNASFVDTRKVLVEQIDKKIEELDKSPYWDWEVNDESAYPPSFYCQFQMFAQLNPVPKEITQSDLLDYEKELADPQGISTVKPPPLLLSAELYSPNCQLLLSIDKEPGIKIEKYYRKAVAYAGMATAIAIIQIFALIHQMEFTPTPSSVSNVSYWTIAIQAVMDGYLCLLHLTTGVVIENVFIPFATAAFFTFILVSIFGMRYLLVVWRIQRPELIRPTVSEQQQQQQQQQEESTDASENTLPTANIRRPPTTTTEEASPYREVTYLYYRLYAILLLGLFLFYQSITRSAFIQNVILGTLGIFLYSFWVPQIVRNIWRGCRRPLSHTYILVMSITRLSIPLYFYGCPTNLIGHETSSWIWVIVAYVGLQVVILLLQDAFGPRLVVPSRYLPDTYDYHPILTTNIDEETVQQEISQPKDCAICMLPVDIANHSHSGLNVLTRANYMMTPCHHLFHTECLERWMRIKLECPVCRAYLPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEA0</accession>
    <name>A0A367JEA0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL20_2</name>
        <name evidence="5" type="ORF">CU097_010829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001511">
        <property type="protein sequence ID" value="RCH88205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEA0"/>
    <dbReference type="STRING" id="86630.A0A367JEA0"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="4">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="23822" checksum="B86992D4D6D60B04" modified="2018-11-07" version="1">MDGWMKMMCELGGIGMTCIQPNGLTLSSQQCLKEYQVVGRKLPSEQEPAPKLYRMRIFAPNEVVAKSRFWYFLKKLRKVKKAAGEIVALNQIHEKRPEQIKNFGIWIRYDSRSGTHNMYKEYRAMSRVEAVDTCYQDMAARHRARFRSVQIIRVAEVKDADVRRQYIKQLLAPKLSFPLPHRIVKADKKHRALFIAKRPTTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEQ1</accession>
    <name>A0A367JEQ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001470">
        <property type="protein sequence ID" value="RCH88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEQ1"/>
    <dbReference type="STRING" id="86630.A0A367JEQ1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="279" mass="31694" checksum="D6278653A72B515B" modified="2018-11-07" version="1">MTVFEYKEGRKVVNDKDIAYMLPVDGLEVDRLKMNHDLWKCIIGGLFKSPIHDRLEKGIRVLDIGCGPGWWTLDMAKLYPSSEFIAIDMADIFMTQDIPPNVTFKQMNAGVGLDFEDESFDFVFQRFLVMGFPTDQYLLSIQEMKRLLKPGGAIEILELINKFENASPAFDRFCSWVNEALATKNLDAFVAEKIPGYLTDAGYRDIQSIDYNVPIGSWGGHVGKLYLEVLKLALPASRVMVISHTPVTLDQFNDNLGQVLLDAHHFQVSNRYKLIYAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFG0</accession>
    <name>A0A367JFG0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001427">
        <property type="protein sequence ID" value="RCH88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFG0"/>
    <dbReference type="STRING" id="86630.A0A367JFG0"/>
    <dbReference type="OrthoDB" id="3044029at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016827759" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18138" checksum="3C8DCC5665C7E663" modified="2018-11-07" version="1">MQSSVMYILFTLLALAVVSLQALPLNKRGYSIQLRSGTEFCSFVPPHAGDDVGGTENDGIPMCTSSNLGGQQFPAGFIQSAHYLSTSNYVQVTGRIDRTKYNLKSSDGGGQYDNKDISGVTCNGYKYFVNLIEPDANQFCIRCCKSQSDCRLGISTAGCETIVPGNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG66</accession>
    <name>A0A367JG66_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_005998</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01001382">
        <property type="protein sequence ID" value="RCH88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JG66"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="420"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="574"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="690"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1116"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1207"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1333"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1271"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1137"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1207"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1236"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1333"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH88920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1687" mass="193050" checksum="5687BEB9D4FC2702" modified="2018-11-07" version="1">MEAFVTLVATDSYASGALVIAHRLRDLGSRKELLCLVTPNISTHVQNMLSKYYKTIPVETIRSKDHQNLLLLGRPDLDISLTKIHLWRLTQYKKIVFLDADTLPLQNIDELFDRPSFSAAPDAGWPDCFNSGVFVAEPSESIYQDLVRLAAETGSFDGGDQGLLNTYFSSWPDSSSHRLPFTFNATPTAQYGYAPAQVQYGQSIKIAHFIGQNKPWKYQRFADGKVLPMGDAWEGTSRMVQTWWDTWDKYYGRISPYQLLSFGISTFDTGFQTRPIVPFNEAIENAWENERYDLDHSRRQVKPMPTLSAITVSQPSWLQEELRAIAENEQRQLQQMYLQNKRPKQQYHDEREPYSMIKWDPAYEEPPSSGSLGADIPDLSSYRNVWDQPLENQQHVWVAPVFQPEPEILKKPEYAQFVEAQQTSQEQEQNDEHNDGKEQGRSQEGEHRYHQKTHDNNNNSEQQNQNKPEVSHPIAFPWEANPHHFPAPTRVWQDEMIRQDNSADRKNESRYEQHEEYHNRHLEHKQHEQHGQERYYHYEEHQPQTYHQEPSETIHSQDTLEQAHGQLDAYQETTPSHTLTERVPEENHNQHEQLNVKHASEKEREQTEVSAYHQHDETNRQIEIEQEEATEEEHKQAPLFAIDEILSPSVKTKIDEFIAELHKDEEDDISDRDLIPINFKASSRLHSGMYTPLPLGSRNGSRVGSRTVSRSGSRRASIVSSRRNSVPGTPKKSHVALDISVPTLVDDSIPNIDQPSNLFADFSSSIFNRKTPYTSAAATPAVALTPDAEQSEYFGHIGETLSDNEDEGFDNDSFEMTNYDLSDSLDVACHSKDTVTKWNPLEALENLKSQSESMILRKTLTEALTKAAKEQEELERLEQLEPAEEKPKRVQRFRSAWDMDDDTELGLPSALASGQSSPRTPMMRGLSDNLSREIEQEKERYRQQRESLSMAQPQTAIASLLEAELDLSRGTLFKKKYELQHVQQMPPEVQSTPFPAPHFGQDEEEKAYTAYFSEDVIKEAKQRLDILKNDREEQMISDGTLPLPVSTGSLVDDIQFSTQPSHMYQHSKYQFSDDFDSKNYTFNFGFDEHHKLKIYQSDLIQPDILATVKPANTVEVSENPLRKAEKSDSIQTSQNEQSEKRIHSDHTIQSRQEDVPKESEQPKVHTENMIAIEKVVTAVQTEIRKEKTATATEEEITIITKDEAGSTRSITTTGQNAESSRKEVVSSEEEYVIVETDEKRQQPKQTASEEEHTETEKLKHAYVKDLRVKRVDEFEKEKQQDEQEVVENTERVREILVESTKEDDEKKSERLESEASIVNSEHTHIYELVDDETDDQAEEESIEQQESAYGGSDGQQEAFEEHLHEQYTIIDSNVVVAGNYTIDTIEVEDDDVEEQLENETLQTDVGFIEVQEDTEEAMETIEIEEDEEEQILEVDIDPLEEQRAVIKREEEFTELEDNFDEEITEECIQVDMVEEQDEKATEVIELEEESIEVETISQEANVETIEIDTSSRDVQVFTKVDASSSSNAFSPARTIITPEKSTVHHSLATSSGFIRTESHGTSTQAKDVEESLTTQVAAQIVDLPDSRFSAARTIITTTTTERSSRPTRKLSIAETLLSSPRPSVAPIVTTPVIIQTFEGKGDTPVIDHEVVNRTYALRHLKRPLYPAVLIPLDPKNHHHPLSTISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG92</accession>
    <name>A0A367JG92_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001387">
        <property type="protein sequence ID" value="RCH88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG92"/>
    <dbReference type="STRING" id="86630.A0A367JG92"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="22122" checksum="5486B22498A8DB7B" modified="2018-11-07" version="1">MTYFETLKRSYTDVDTSKGVDTEQFLEATEGLVKLFDLLGSAAFSVVQSDMNGNIKKIRDRYLSNPTANNTLEELMKNEAPEKKRVATEGLLWLTRGLDFTAQALRRSLSDPAEELNTSFTKAYEQTLKKHHSIIVRPVFALAMKACPYRKDFYEKIGAVNDAAIAQMKAWLEALENIISIIQNVFKANPAYIKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGD1</accession>
    <name>A0A367JGD1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001360">
        <property type="protein sequence ID" value="RCH89032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGD1"/>
    <dbReference type="STRING" id="86630.A0A367JGD1"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21987" checksum="75362A4164B80592" modified="2018-11-07" version="1" fragment="single">VDDGPLYEYADPANQQMLAAINSGRAPLSLLNVRHGQPVEVRVIKRQDEDYTPPPKAPPKPFEGVGHRLGSPATYVAPPTAAPGAFPSTGGAAAPTVDESQPVTSIQVRLGDGSRMVAKLNHTHTIGDIRQYIEANNAGSSNRPYILQTTFPVKQLDDNNQTIKEAESCLSVAHIDVHKSEKGRIRTIVMFFFKSPVPAGLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGD4</accession>
    <name>A0A367JGD4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPB4_1</name>
        <name evidence="5" type="ORF">CU097_003664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001362">
        <property type="protein sequence ID" value="RCH89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGD4"/>
    <dbReference type="STRING" id="86630.A0A367JGD4"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="16828" checksum="308E606537DB5324" modified="2018-11-07" version="1">MTSVKQPKKRFIRRGGAEQEDASNLKLGEEFDNAQCLYLSEVRVILDAQDNKGIEVQNRATTNAVLAKTLEYVRNFSRYNTMEAVREVRQIMAKDSLTQFEVAQMANLCCEEAEEAKALIPSISTKYDDDELQEVLNQMQQIRKFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGH1</accession>
    <name>A0A367JGH1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_003626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001360">
        <property type="protein sequence ID" value="RCH89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGH1"/>
    <dbReference type="STRING" id="86630.A0A367JGH1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="300" mass="34418" checksum="F0908113B4BBC72B" modified="2018-11-07" version="1">MYSEYSSNMPTLGASPSVSTPYLDAAIDTPYTPPFFDITSDEFSPYLAFTSFNNTPVLKQDLCVAGYLNNNQDSVAEFNGDPTELLIDKSKTPQMPASNSLFAPVQKEENEGLFPPLGSSQQTVDTDIKPGMDQDLKDLLDLGSPLSDQMDEGSDELIKEEEKEPEREQCEEEANAKRGRKRRLTEEDEPKKKRTYTKKSNSAKTAEPKLYQCPICDHVSKRRYNLSTHIKTHDKNRLKEFECPQCSKRFDRRHDRDRHLATVHRGERSFVCKDCSIHFSRRDALNRHLAQRHEDDNEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGR1</accession>
    <name>A0A367JGR1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_009606</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001346">
        <property type="protein sequence ID" value="RCH89120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGR1"/>
    <dbReference type="STRING" id="86630.A0A367JGR1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="16">
        <location>
            <begin position="152"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="15">
        <location>
            <begin position="786"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="17">
        <location>
            <begin position="1076"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH89120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1104" mass="126957" checksum="22522468C2337D1E" modified="2018-11-07" version="1" fragment="single">FLTPLLRSSYVVVLPEYTFNYPIYTKADSVSTWVVQWYCLLEKITDDEARPIFSACLPVIYYGNLDVALYLLPHLILHVILSASASDIQNIVNEILLVLNTNSKLDKADQKNRASLQAVVAITEHCRQWLYRAGSRDTTMVGRFLEAIPDKLMAKASFYAKAYPQALMHFENYIKTSSSNLLEDEETMRFLRHIYVKTENMQDLQALLSMYSIRFSNDEEIIRFENMGKWKEAEIYHMDNVAKNPHDLSACMSFLECLKKSGSYASILYFSDKYVDANPHWSTHMNAFKMDAAWRMGDWNALDEASKHQTIETTESFIARALGSMKKNRNLEAASYIEHARRDLISSLGAKTIESYQKSYQTIFKLQQLQELEDAQKAWESKDPIEKVSELENKWNRTLKLLMPQYQHIHDLLELRRTALYDIRPRQQSVSCGGIWLDIAKYSRKNGHLIVALDAIVNAERAGNEITHREKAKWLWQTGRRQDAVTMLTNLEDVTANDAIILNSFYLKDSSIYNGEKARFYMTHARKGPEKQEKANVQYAMYLCKQCTGRPPSICIRVYEIIIKTVLKALSCGSKYYYTSMSKFINYWVKMVSLADENRKSSEGQSFAETLTRTNELIRTALTKVPIYQFGKFLTRLISHLTVGNTDMANTLSCIIEAVFSTYPRNTIWLLLNTLDGRTPLLTDRINTILGRVKANKQNTVIPLVIEQATYFRNFLHRVSKYTVGDRAQSTLNLKDIPKLKQVLNFDGFVLTVPRESSLFPRLPELIKKGETFDPFPGEIVTITKVMPEVDVMRSLQQPKRITFVGSDGKNYKFLCKANDDLRKDARMMEFNYMINSFLKKNPDSRDRNLYIRTYAVIPLGEEWGLIEWIDNLFPLKAIATDIYNNLGIKANQVQIEYRNKRQLPGLTDEELLELFKKVLAQSPPVLHKWFLKSFPEPNQWLASRTRYVKTLAVMSIVGHMLGLGDRHAENILFDRTNGDTVHVDLNMLFDQGLRLNVPEVVPFRLTHNLVDAMGIVGYEGQFRKTCEIVLQILLNNRQALTGVFQTLFNEWSQSDARDRASRTMGVLKKKYATAEESGVEAEVDRLIKAATDIGNLSKMFPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHF1</accession>
    <name>A0A367JHF1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative zinc transporter msc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MSC2</name>
        <name evidence="11" type="ORF">CU097_004475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001302">
        <property type="protein sequence ID" value="RCH89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHF1"/>
    <dbReference type="STRING" id="86630.A0A367JHF1"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="45"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="407" mass="45103" checksum="1287D9D7FA60027A" modified="2018-11-07" version="1">MFHTSPLDLPTHDISPQYAYSKSNPLATAKQSLDIILSNQDSKQIFYFLLLNLSYMFVQLAYGVWTNSLGLISDAIHMFFDCLALGIGLFASVMSKWPSNAEYSYGYSRIETVAAYFNGVFLIMISTSIIVEAIQRLITPPEMNTHRLLFISFVGLVVNLVGIFAFNHGHHHGHHHHDHGHHHHDHGHSANMQGVFLHIMADTLGSVGVIASTILIKWFGWTGFDPIASLFIAVLIIASVIPLIRQSAAVLMLQLDDGTVATIEGTLEEVKAMEGVYSISHSRFWPYEAESVVGSLHVQVKDNVDTQALRNTITALLHSHIHGLREVCVQIELQSAKKKNRTVPEKGFFHSPLVYSSSSLSSNAHINYRSNTSTPTPMINSPADINSSNSPNLNPIISVLQKQTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIB4</accession>
    <name>A0A367JIB4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001242">
        <property type="protein sequence ID" value="RCH89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIB4"/>
    <dbReference type="STRING" id="86630.A0A367JIB4"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="61"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="253" mass="28989" checksum="081BD4E4A5110B8E" modified="2018-11-07" version="1">MSVRNNPLTSREEKHLEDLIEQRVSDHKPLQYILGTQPFCELDIVTRPPVLIPRWETEEWTDKTIRLLYPHLAKKEEKMRILDICTGTGCIALALSSQLPKDSVEIIGLDISEEAIELANHNLKVHQRKLKNPVRFQQGDVFDYSPSDKVHMIVSNPPYVTRDEYEGLDPDVKNWEDMRALVADDQGTMVHKRIIEICKEHCQAFAADVPKVLMEIGGSHQVEPLTRTLKNNQLTNIQVWKDLAGKDRVIAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JII6</accession>
    <name>A0A367JII6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001232">
        <property type="protein sequence ID" value="RCH89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JII6"/>
    <dbReference type="STRING" id="86630.A0A367JII6"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="261" mass="30853" checksum="DB2B7AEF62037985" modified="2018-11-07" version="1">MSIQEYAPGDTVFAKLRGYPWWPARVENDKDIPPQVLKKKSKTKGLLYTVFFYGSRDYGFFGPESVRPFDREEVERDLKAKKYRTKELIHAIQQALNPSSLEEKERETNRDSQKRTRKRGRSEDERTKKRSKSLSVEKDDEGIVKKNEMADMESFKKTAEFKRVYHIRHKLQKLVYGKEPGEIPKEDYVKISAIIDEIEQLTMTVELIKFTKIAKVLNYACNYCFEENEFDINQRCIQVLKKWKPLFDHHSSQPQLAIFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJJ4</accession>
    <name>A0A367JJJ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_010957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001184">
        <property type="protein sequence ID" value="RCH90055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJJ4"/>
    <dbReference type="OrthoDB" id="2369992at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="616" mass="71786" checksum="D36674323D68FE6D" modified="2018-11-07" version="1">MARRAPCQYCKQRRRKCERSCESEPCARCIKMKRKCIPQEFSSSSDSSIGDDDEVNERRYNDLYQQIEELQMELHNLEIDLNKQRSTAALIKSEPRWTLQIENGQLQLQTEIKSFEELSAYGKAFLRYLSPFGNTFKKVSFVFENTQPYVLHRAITDLTRLAIDNGSADDNMYSNSMIARYIKPEAFIDRLIDLHFHCFDVWLQAIHERSFRKRIEKINKLEDPTTLAICASASVHICRHSFLNSQEKRYVGEYFYRKCMRKLIDMFDDPERELESLVIINIIQPFLFTTMRFNECKKWSSIAWILAESLAKKHPGYKNGNASLDMNTRILYATIHRNHLAARGILSMVDIFLNDRCECIEHVPCRFDFLPDENLLIRYSFEALNYVTQLESHPFMSRVHKRTMKTLVGEKLELTFEDIVFHDDFLIEWWHNLPEHMKISKEPYNCTKELIDSCDNVQKLTMSLYVHSVAINIYANLVNIKINGNTAQIVKDKSIYLALYAAEIILILAKKIENLEEICFTTGKLLFRVMDALTLLLQSKDPSVTLSTRKKIEEYMIVFESVAYLDQEVVAHTSPLTLISPTSSVSIQELYKNYPLPAQALLFDVVHKTITDVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJK0</accession>
    <name>A0A367JJK0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001185">
        <property type="protein sequence ID" value="RCH90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJK0"/>
    <dbReference type="STRING" id="86630.A0A367JJK0"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77916" checksum="863A6B71242D80F9" modified="2018-11-07" version="1">MSGDEPSAEQASPIPSRTTLNSATEQTRLLDSSGTNYNSGNSQTVITMAEQPYENGSNNASLSSGQPTVPVGELTEKIQDILVFNEIKKHQSMNQTANSKNRKAEKDSSSDSDSDSDSDSDDDDAHHLLKKKLSEWSLDRKPGTGKRLRKRDIAFDTLRFATDKWKIMHGWSPSHHESSSEANEVKITSTNVKPVGHDATIQHDRVQEYSQLPSSAESIFNVAKNASVCAILALLHERRQSSGHSTETDIFFQSLALTALTLGIKAQGTSAKQVVLHEMLTVKWLNGKSALEWAVENNCQLILSDERVQTVIQELWESGPDWRQNQNHPSHIWLKPGSDGAAHKSFAWFVITRTTTNFLARWPSPRYQAIVALFSAFVYVGLHVATVTNLDYTSDTPFAFEYAYYVFVASDLLLELFALLSHPTIYLKKPSSYFSLTAVGLLTASAITRFVALVIYDNFLDQHTLLTTSFFLLIFATPLMFFRLLCSWSADKLSWNVAKTNHIVTQCIVNSLWVFALSLLVIFSFWVTLGALQYDDIKPLNMLGLLTLGALHAPEIADTLYYQPATAGALFIAYLFITVIFLGSLLTASFLNTLLNVNKQMDNLKREWNIKRCLGINPTLSMLIPSAIVDVFFGFVLFIARHVFRCQRVTWIEKAHQVIWYIIYSPIILLVGLYELVIVLFKWKSVKIFTNRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJM7</accession>
    <name>A0A367JJM7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001171">
        <property type="protein sequence ID" value="RCH90137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJM7"/>
    <dbReference type="OrthoDB" id="2284908at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="179" mass="20215" checksum="FFC3F9B13A8C33B4" modified="2018-11-07" version="1">MTPQDCSPKDLNKPITNYVLIPLALVQSHLFWLCSAVCWVFKESGIITDDKPNVHIKRNRAHSAPPSTDNATDKQLTKPTQRRASLPEPISCIRSRPTAHDERKGTTCPPVWWQKTRVKLGHAPVHGDPKPASETKMPFPREYADVPMTRVDTTVSSLSSSKSTKRSKRKLISKLFHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJQ9</accession>
    <name>A0A367JJQ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COG7_2</name>
        <name evidence="11" type="ORF">CU097_003818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001163">
        <property type="protein sequence ID" value="RCH90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJQ9"/>
    <dbReference type="STRING" id="86630.A0A367JJQ9"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="214" mass="24399" checksum="883AAF8DC5534C49" modified="2018-11-07" version="1">MTSQLSIDVTDFSNSEFDAKVWINSVLKPSNTEHLEKTEDEIKEMTSMLVTKLQMTGESTSRQFDQLSNSVIKSMPRIKYEIKSIAEEARAIQRKIEAAKQKFEQLEKQTEPTLGQLRKSHTVKTRMEECQNLLDELKLEKSKPVNPVSEVERKTETTIQQDTPSLDPATILDLENPLQIYQNTQDNNNNNNSNNNNAQANNVFKKMGVPVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJS1</accession>
    <name>A0A367JJS1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001162">
        <property type="protein sequence ID" value="RCH90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJS1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="74" mass="8491" checksum="09037DDC67D14C6C" modified="2018-11-07" version="1">MIYMRCLQCPLFENGQFDFSCKKKHIVSIIQRTVALILFKPFVVAIEIIEGELGMNMNIPEQEIEDGSRITKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL81</accession>
    <name>A0A367JL81_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001081">
        <property type="protein sequence ID" value="RCH90704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL81"/>
    <dbReference type="STRING" id="86630.A0A367JL81"/>
    <dbReference type="OrthoDB" id="10302935at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="133" mass="14625" checksum="F8692A56330DF3FC" modified="2018-11-07" version="1">MSTPDNNKTAYPEDYNMGPAQQGGGYPPGSTEAQTTYNPENTAAQTNYNYDNNTTGQSNYNYGNTTGQTDYNYGNTAPQQASYMGDYSQPGAPTAQDTQQETADKPETFNKSLADKIENKLEHFVSRFSSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLF3</accession>
    <name>A0A367JLF3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001077">
        <property type="protein sequence ID" value="RCH90725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLF3"/>
    <dbReference type="OrthoDB" id="2448606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="182" mass="20635" checksum="497DFCB81F80328A" modified="2018-11-07" version="1" fragment="single">TRHGDNRVVTPPLISSSTPETSSSYVCVDELLVDGIDIPELFYQVQQNAYQPACHQSFLLHNNNRLHHHWIPISWKCLNCTCSESSTKSLVDIINIVGKMYRKNIDRLTYDRHSRPRADDVRVAVNSTSPNGAQLMNLDFTFTEPTDKSPIHAPTFNGHPDCIIMSFIYETDNSVNIGYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLF8</accession>
    <name>A0A367JLF8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ACS1_2</name>
        <name evidence="9" type="ORF">CU097_007849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01001070">
        <property type="protein sequence ID" value="RCH90772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLF8"/>
    <dbReference type="STRING" id="86630.A0A367JLF8"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="97"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="545"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="663" mass="73821" checksum="4341807460681F6F" modified="2018-11-07" version="1">MTVNDSNTCMSEEKTYPVPSRLLNDNQLPKPFISSFEEYQKLWEESVNDPNAFFGNLAKELLHWSKPFETVQSGSLKEGDVAWFLEGELNASFNCVDRHALATPDKVAIIHEGDEPGNVRKITYRELLQEVCRVANVLKSLDVRKGDNVAIYMPMVPEAVFAMLACARIGAVHSVVFAGFSSESLRDRINDCGARVILTSDEGRRGGKNIATKRIVDEALKNTPTIEHVLMLRRTGSEVPFTPGRDLWWHEETLKARPYCCPENVNAEHPLFLLYTSGSTGTPKGVVHTTAGYLLGATATVKYVFDYHPEDIYACMADIGWITGHTYLVYGPLSLGATSLLFESTPTYPTPSRFWETVEKHRVTQFYTAPTAIRALRRLGDEWVDRCDLSSLRVIGSVGEPINPEAWEWYYDKVGKRQCAVVDTYWQTETGSIIITPLPGATPTKPGSATFPFFGIKPVILDPASGKELEGNDVTGVLAISQPWPSMARSVYNNHNRYLDTYLYPYKGYYFTGDGATRDKDGFIWIRGRVDDVINVSGHRLSTAEIESALILHHSVAEAAVVGGHDDLTGQCIHAFATLKPNIEDSEGLEKELALQVRKVIGPFATPKRIYVITDLPKTRSGKIMRRILRKIVNGEHDSLGDISTLADPSVVEQLIKHVHGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLQ6</accession>
    <name>A0A367JLQ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001055">
        <property type="protein sequence ID" value="RCH90872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLQ6"/>
    <dbReference type="STRING" id="86630.A0A367JLQ6"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="494" mass="56577" checksum="4602CED685F31652" modified="2018-11-07" version="1">MYDDDEEELELLRQYEEENIVGDGRDTYSSEELDSDLEEKILSVTHYDVGVDKKKKKTESAAPERSTPTAPVSAPDARGRVLPSKSARRTVSTVHAPIDFDRKRADFSAASELKLNSSDEEGEYRSEEEKEEEMADVVASDSSSEEEELREAPPPVTRHINLDDKQYMDDVETSEEERELGAELRVLIEDSIQARGGQSRLGRPSNARVIICYRCKQPGHQQQYCLMCTECGLKHRGPCMWPRYCRLCKMDDHNKEDCRGKRETRDCELCGDKYHNTEICTKMLHIYDGEKPASKSMTIFCYNCGDYDHFGDQCRRYSYNSIIPSVFSEESINYSELNKNRKKSNKRKRREHYYFESDDDDISRKKSKSSRDYRHPSSNNNNNNNNNSSSSHRMYNKGSPSSSSTTSSVYSRDEGKKRKKGKKVLDDFFGKQKGNRSPGSNQAITGNSNWKAINNYMNSLPQPSRSGTVQLNKNKNNRERADLPKPSKSGVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM89</accession>
    <name>A0A367JM89_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001025">
        <property type="protein sequence ID" value="RCH91070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM89"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="49411" checksum="91D1C84A53CFF848" modified="2018-11-07" version="1">MRVRMGADQYFSKCADTPTGEWNEGFVFRVSYHAQLFNTIEFDLYDKPHKIWPSAMKHIGKAKLKLSSLSGREKIFVTFLPIYEYRSHRLLPADYKPVLSNIIDKTTISKNVGDLHLIGSVQVRIRYQFQHPVDSPRCLPSLSEKGDTASSQLSIASSSSDISFHSTNQAQERRTSYGRSDLVRNQNDVSEIFQKRLTRIMSTRIPSEQGIVNDIHGNTAYNTYPHHGSSQPPSRSSSQEHMNQKQMQEHHRHIYWLFKSLNDFPKSTRGRRYGFSQTDSDDHIHFNPDNMDSASHKEHHKVSHKARKKAEHIIHSVNFGDRNFASQWMQDSFDDVALSHPMVDKLIGMVVSKQTRAMVRAIIKTANAFGQGFRATGLQMLKAALIIQKFYELQPMPPFSKPIQNIAFIDDACPLWRIGDMIFYFSQSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNK9</accession>
    <name>A0A367JNK9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ELAC2</name>
        <name evidence="12" type="ORF">CU097_012668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000960">
        <property type="protein sequence ID" value="RCH91508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNK9"/>
    <dbReference type="STRING" id="86630.A0A367JNK9"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="155"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH91508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="436" mass="49837" checksum="239F9A3EB1D15798" modified="2018-11-07" version="1" fragment="single">YKKWVASFDGNTDHIFSSEEICKQDAQFTSQALCQVKLSKLDDKIFAIPKYSNTPEQDLSSVEGLPAKSFALDNMAIYNLEPKRYLEYSNQPVFDHTNTELESIKAIESNEEYKEAVTKARTEASKVDISGRFPGDDIEIVTLGTGSSIPSKYRNVSATLVKIPDYGSIMLDAGEGTFGQMIRRFGIQQVDDELRLLDCIFVSHLHADHHLGVIQLIRKWFRVNTNEASALTVIAPRVYNDWINEYIQVESFGKGTRKRIRFLSSEYLVHLYEKNPSKKVPMLHEIQDRLGLSVIKPIEVIHCRWAYGLSIEHKDGWKIVYSGDTRPCNKLIDHGQNATLLIHEATFDDIEKEKAIDKRHSTTGEAVDVGQRMNARYTLLNHFSQRYPKIPSLSGKQENICFSFDLMSVLIKQMPILPKFTDAMQLLFEEEEDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNL9</accession>
    <name>A0A367JNL9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ACOX3_1</name>
        <name evidence="18" type="ORF">CU097_006646</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000957">
        <property type="protein sequence ID" value="RCH91527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNL9"/>
    <dbReference type="STRING" id="86630.A0A367JNL9"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="53"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="317"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="528"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH91527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="708" mass="80408" checksum="573102E0FFD27E24" modified="2018-11-07" version="1">MTVIPLSESKNPRAKLALERLNQLKSQLNLSPSSMSRQAPKDMAKERAAAEFNIEELAKFWAGGDEKYRLLQKAYDIIKNDPELVVQPPRNFLELSRDEMREFTMGQIYRVIHVVKDTKDKDLAYEIARATSMYSESFSMRFFVHEMLFRNVINMLGNKEQQDRYNDDISNYRIFGCFAMTELGHSSALREIETTATYDFATDEFILDTPTITGTKWWIGMAAQTATHAVVIAQTVIDGKNVGLNWFVVQLRNKHTGELEPNVQIGDIGEKVGHAGVDNGWIQFRQKRIPRIDMLAKWVQLDRQGNYKPAPNPAVMYATLIPERLSLVTVTTQMISQALTIATRYGVVRRQGAKNQQIMDYQSHYVKIIPAIAFIYMVRSTADVLNEHFDISTAGGKMDPMVYLNHMGDMHAMAACLKGLTGWYSTEILETCRRSCGGHAYSAYNAIGHIIGDWGVMTTGGGDNVVLLQQTTRYLLYRLEQKLEFDEYPDLKFKSSTIYIKDAKRYLENKIWLTNDASDCIKDFTMLTEALHTILVKRLYSIHAARQQGTPSDQLLLDSVRVAEMHCATFMFNVCAEKFGQPVGTPGIEPSVLAIMKKLTALWGMHVLYTYSDQGFKEGYFTPEHIKSIEKTYTDMCKSLRYQVIGLTDGFGIPDFVLKAPIAKYDGDIYQTYFDTLLTAPRSTGIPPYHGKYIKPLTECENPNALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPL5</accession>
    <name>A0A367JPL5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACT1_2</name>
        <name evidence="10" type="ORF">CU097_013126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000915">
        <property type="protein sequence ID" value="RCH91825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPL5"/>
    <dbReference type="SMR" id="A0A367JPL5"/>
    <dbReference type="STRING" id="86630.A0A367JPL5"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="22049" checksum="BD78FF694C7F3265" modified="2018-11-07" version="1">MAGRDLTDYLMRILAERGHAFTTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSALEKSYELPDGQVITVGNERFRAPEALFQPALLGHESVGIHETTYNSIMKCDVDIRKDLYSNIVMSGGTTMYPGIADRMQKEITALAPSSMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPM5</accession>
    <name>A0A367JPM5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PEP5/VPS11 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000907">
        <property type="protein sequence ID" value="RCH91887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPM5"/>
    <dbReference type="STRING" id="86630.A0A367JPM5"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="15715" checksum="B4418D0EA38D2588" modified="2018-11-07" version="1" fragment="single">MFIAYDGGRVTHLKQLKQKNILVTIGEDDTQSGIPILKFWDLDALKSTEVSDDIIIPTLLRTIKIQHGGKPYPVSTFVILENMSQCAVGLANGVVILIRGDLSKDKTVKQKVIYEGDEPITGLGFREQTKSTILFIVTTNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQC8</accession>
    <name>A0A367JQC8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000870">
        <property type="protein sequence ID" value="RCH92147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQC8"/>
    <dbReference type="STRING" id="86630.A0A367JQC8"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49044" checksum="25B12A9BCCF64795" modified="2018-11-07" version="1">MSKGVLQLYYSPLTQVVLLGLVCLCCPGMFNALSGLGAGGSMSSNVGLIDSANGALYGCFAIVGFFSGTFTNTVGVKHTLTIGSIGYVVYSASLWVYDRKQVSGFVIAAGVILGCCAGVFWSAQGSIMMSYPEEKNKGKFVAIFWALFNVGGILGSVIALALNLENEASGGVSTSTYIAFVIVMIIGVVLSLAIASPSRVVRPDGTKVAVAKAMHWKKELKGVLLVWKEWRMLCLIPAFLASNWFYAYQFKVNTVYFNSPARALNDTMYWTLQIIGSLIFGCLLDFQGLSRRSRGLLALVILFVVTMAVWAGGFAFQLTFDNGFDKPIGWKDARFGGPFVLYMFYGFSDAIYQTYLYWLMGAMSNDPSLLARYAGFYKATQSAGAAIAFGIDAVSVPLRWECLICWVLVFVSFPLILLVASRVSETNMNDENDSLSSKSIDKKTAEAKDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQI6</accession>
    <name>A0A367JQI6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SRB8</name>
        <name evidence="10" type="ORF">CU097_012540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000868">
        <property type="protein sequence ID" value="RCH92166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQI6"/>
    <dbReference type="STRING" id="86630.A0A367JQI6"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="589" mass="67387" checksum="360FCEAD8D4A7832" modified="2018-11-07" version="1">MPSLGYPDIFPQRPGQEEDILTESNIRQGFIDKPIVSSENSSAHDIICGRLQEDQRALSDLSDFIVDVLHRQHRASYITGSSSFKPPMRTTLIDAKREQWMHELASGVIPLRKLARNVPHGFKGEKLLETLAIKQVPFLRATWYIKIVGLSEMSQRNASNAAASMGPQTIQWTMTVTSYLKKQLGELMPSHYGNANSAASPHATSGASNRGYKNYSHHDNPSKPWLSAESRSKFEQKWTYSVKLTHWQYYEGLLDQRTFLKWSLDTLAASSSFEIMWVILTGLVQDYYHHLLNMIIGEDINTGVMKSSPDVRRMMNEYWTMVKARNEMFCGNIENNEMKVDKNIKLQSQSSPVHIHDDGNEERIVHILDSIGKNVDSIAGLQIKGDIWVDARGRSAKWAAKAIFRSSSPSEPESVVKIIHSMCRWAINETRYSDWKAYLIASILLSWKEDNNTTEIKTLLQETLMRFLDGETYSENMSEDNEEVDMEYTSEDSDKEIENESLNNLKHLARLAVMGFDHHDTDCLFGADAQDMTQPLSTDTFDSYNLAFSQELRQKFVDMMESTTRFVVLEFTSNWLLNEVKRFVVKSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRC4</accession>
    <name>A0A367JRC4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-activated serine/threonine-protein kinase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SNF4</name>
        <name evidence="6" type="ORF">CU097_005772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000823">
        <property type="protein sequence ID" value="RCH92468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRC4"/>
    <dbReference type="STRING" id="86630.A0A367JRC4"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="276"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="336" mass="37711" checksum="4BE7C375ED8D79D9" modified="2018-11-07" version="1">MSYSSGSVSTADNVDSETLTYQDPACEIQNLMRCFLKEHTAYDVLPVSYRLIVFDTRLLVKKALNVLVQNGIVSAPLWSSETQKFSGMLTVADFINLIQYYYTHSSVDEALKEMENFELAHLRNVEKQVGAPAPQLVSMNPMSTLYDACKLLAESRAHRVPLLDKEPDTGTETIVSVITQYRILKFIASNFKHTKALRQPLSELRIGTYDNIATASMSTPVIQVINMFAEHNISAVPIVDKNNVVLNVYETIDVMSIAISGKYKELDMSVGDAMEARPKDYPGVHTCTLNDTLHSIFRTIRKQRVYRLIVVDQDNKLIGIVSLSNILGYLVGYKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSN7</accession>
    <name>A0A367JSN7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-protein Rab-4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RAB4B</name>
        <name evidence="4" type="ORF">CU097_010879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000791">
        <property type="protein sequence ID" value="RCH92701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSN7"/>
    <dbReference type="STRING" id="86630.A0A367JSN7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="230" mass="26090" checksum="D3614ADC16EFE83E" modified="2018-11-07" version="1">MLADAYDFLLKLLLVGDSGTGKSCLLYHFLENQFKKDSVNTIGMEFGTRIIHIGDKSIKLQIWDTAGQERFRSLTKSYFRGAAGALVVYDVCNRDTFLGVRSWLRDVRTLANPELVIILVGNKNDKADEREVSYLEASRFAQEHGKLRLKLKDKTNSMKKEMMFLEASALSGDGVEDVFFKCARSILSKIETGQIDPERSGSGVQFGDSSFRRMTQRTRIRKKERSCCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTM5</accession>
    <name>A0A367JTM5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPS17</name>
        <name evidence="4" type="ORF">CU097_002065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000718">
        <property type="protein sequence ID" value="RCH93268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTM5"/>
    <dbReference type="STRING" id="86630.A0A367JTM5"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH93268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="12093" checksum="A782DCFCC3EE1174" modified="2018-11-07" version="1" fragment="single">MGRVRTKTVKKASRVIIEKYYPRLTLDFQVNKRILDEVTIVQSKRLRNKIAGFTTHLMKRISRGPVRGISFKLQEEERERRDNFVPEFSALDTSAIEIDPETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTR3</accession>
    <name>A0A367JTR3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000709">
        <property type="protein sequence ID" value="RCH93354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTR3"/>
    <dbReference type="STRING" id="86630.A0A367JTR3"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25378" checksum="67E01FC8FE6076E1" modified="2018-11-07" version="1">MNQSNLLHYDLARHSTKDTIKMLTFLLEKVTKANDQHQPSGERRKSLTYTCFHARSIPSISIHAYLTRILKYCPCANECFLALLVYFDRMSKVTLGKQNTGLRIDSYNIHRLIISGIMVASKLFSDVFFTNTRYAKVGGLPVAELNTLEIEFLALNNFSLFISLEELQQYGDQLLTHWKMENENIPQYICTDDNDNKEEDISPVKRKARHLSIDKHDDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV41</accession>
    <name>A0A367JV41_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000649">
        <property type="protein sequence ID" value="RCH93844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV41"/>
    <dbReference type="STRING" id="86630.A0A367JV41"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="45"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="423" mass="49013" checksum="809D4C2C67D2F99A" modified="2018-11-07" version="1">MSCVDLSFIDQTNTPSGITVLRKKLQGYVGFANLPNQVHRKSVKKGFQFTCMVVGESGLGKSTLVNTLFNTQLYPPKETVELTHETTQTVEVKSITSDIEENGVKLRLTVVDTPGFGDFVNNEESWKPILDNIEARFDAYLEQENRVNRRRMVDNRIHACIYFIAPTGHALKPLDIEFMRRLHTRVNLIPVIAKADTLTEEEVAAFKERILADIAYHNIQIYQAPVYEYDDQETIAENKEIMSKIPFAVVGSDKEFEIEGGRRVRGRKYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEYTNDVLYENYRTEKLTAMGIQQDPSVFKEVNPVQKMEEERLAHEQKLAKMEAEMRSVFQAKVQEKEAKLKQSEEELYARHKEMKDALEKQRADLEEKKRRLESGRPLTPEKTAKKKGFSFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVN1</accession>
    <name>A0A367JVN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000631">
        <property type="protein sequence ID" value="RCH93996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVN1"/>
    <dbReference type="STRING" id="86630.A0A367JVN1"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="348" mass="37657" checksum="731C98D2D5318C82" modified="2018-11-07" version="1">MVSVILSDNHSFDSKFKYGVEYKENKPSANLQDYQCAVQLKAAAFNHRDVWILKGQYGGIRVGSVLGSDGVGYITKNGNVGQRILINPGYGWKSDERGPEDEFHILGLLPAIGTMTEEEVIVEKEDIASCPEHLSLAEAAALPLAGLTAYRALFTKAHVKKGDHVLVTGIGGGVALFALQFAVAVGAHVYVTSSSPEKIKKAIELGAKGGINYKDDNCIQELQKLLNGNKISAVIDGAGGPLYAQYPKVMRTGGILVNYGQTANVAEGIKFSMHHVVKNIELKGSTMGSRAEFHKMVQFVDQHRIKPIVSHVWKGLSKSSFEEAVATMSRGEQFGKLVIEFNNGSPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW50</accession>
    <name>A0A367JW50_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HER2</name>
        <name evidence="9" type="ORF">CU097_013146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01000602">
        <property type="protein sequence ID" value="RCH94222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW50"/>
    <dbReference type="STRING" id="86630.A0A367JW50"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="493" mass="53821" checksum="10DDB6586B2FDBFE" modified="2018-11-07" version="1">MIPRLKSRLIATTTHSLQTCRHSSSLAIQQCLHTIDNYNSEINAFISINDRKLLEEKAKESDHRREQGQPIGPLDGVPIAIKDNLCTSALPTTCASNMLKDFISPYDATVVQLLDKAGALIVGKTNMDEFGMGHSVFGPVINPHSLNQENKRLAGGSSGGSAASVAMNMCRVALGSDTGGSVRMPASYCGIVGFKPSYGRCSRYGLVAYANSLDTIGILSRTVEDCANVYNAISKYDELDPTSMPLKLRNEIDEKDKELASRWEKDLSGLVVGIPQEFYVDSLSPKVISAWREGIDRFKQLGAKIITVSMPHTPLALPAYYIIALAEASSNLARYDGVKYGHRSATEGQDEDQLLFASTRTQGFGAEVQRRILLGTHVLTAGTYETLFLPAQKARRLIQQDFNNVFCQPNPLMTHECGQAHLILIPSATGDAPTLKEQGMNEYINDVMTLPANLAGVPAITVPFIKDGQPIGLQLMSQYGYDQFLLSMAQKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWD9</accession>
    <name>A0A367JWD9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000608">
        <property type="protein sequence ID" value="RCH94179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWD9"/>
    <dbReference type="STRING" id="86630.A0A367JWD9"/>
    <dbReference type="OrthoDB" id="10349005at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="189" mass="21863" checksum="4F7F54800CCC4979" modified="2018-11-07" version="1">MNFDVSGDEALQAEKEDKQALQKDDERKTIGKIPDAIMSLEKYGVPFALVEVSGPHNQSNHHHFVSDKVKLAKQLKASLKKIRRMIEHGDEGLYEYIKLFWYSSTPKQDVLLQPVPAKSRHLCLRRSPFFRPCSPFWIYIKLWTRTRKESMESEVEDYFNSDSGGDSSGESDDSRDTMHASPKRQKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWM9</accession>
    <name>A0A367JWM9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000591">
        <property type="protein sequence ID" value="RCH94308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWM9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="13013" checksum="C70A358E47286FE5" modified="2018-11-07" version="1">MIHFLSDQGRNIALRWTSSSSYEQEPDIRPNFGEVNPGNSTITKYYLYMGDLLTQDHLKTLCGRFDDDYRSVPKLMQGHTKTHKCHQDLSKRPMKAQNASRTNPFTEMIKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX29</accession>
    <name>A0A367JX29_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000568">
        <property type="protein sequence ID" value="RCH94534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX29"/>
    <dbReference type="OrthoDB" id="411646at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="271"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="644" mass="73698" checksum="4C8D73987435C5B2" modified="2018-11-07" version="1">MALPFLYKTSVKKKKESLDSTLELLYKKEQDNVLEPEEMDENFFYKHITTHFHSLFCESSIICVPHSKSIRGLVLTKDIIEAHCFQPSPYFCGQFIATKQKQKIIALDFPVITTILGFKEQRTVHVMAEETVYLKNKKIRVFCIDRLLEGEAPKYYHKSAITIPPVRNAKTDLEFLNMFPENMEALYELQSAVQEFIDSYVYIKGYNKNTVERIQHMYMKTYRTILQKNKLLQDSCRTPSEHDQFLELVENVVMSFLHKKIWVQTLQPLLQSQDSYLDSVCFAYSHVVLSQYSLRYPLSEMHVSCFQNAICEFQKIDTQAATPLEKLAVLKSTLDLISAAVHDYVTHFGHSTSDTSVTSDEMIPLLAFIIVQSHVPRMASLIYYMQHYRLARMIEGSVYSFVLATLKSACEFLKDDPLSLYDIATATQRTRSTSFHHKPKSAPLLQSSSYYHHRKAQSADFDIDSSNNSRNSRQHILRPHIVLPHRSTSHEHHRKSLEIPNDWLIYNSPSSSNTTYSSSHSNNSNTSPKPHLGLSRPMISTTFPSISNSTPLYQTSKLGRSLSASPVIKRQQPPEIIHVPDRISVDPTKRPASICIDTRSIHSIEKGEDEELMGDFLKGLSKLDGNVVGERTGSIKVFNRIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXP1</accession>
    <name>A0A367JXP1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000552">
        <property type="protein sequence ID" value="RCH94667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXP1"/>
    <dbReference type="STRING" id="86630.A0A367JXP1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="54626" checksum="E6590FEA9FBBBF2D" modified="2018-11-07" version="1">MLYNLMAENDALKPSVCFQKMCQVMVNEGLNKQQVEDFRLILHMLVLESSRHNIEAGKTWILEKCTCPNQVSALMEYLLSLSRSTTAREERLHLIYLLNDVLYHASRRRLFWIRDTILPLLVPLLKLAYEAAETDEHRAKVTKCITFWSDRDIFDEASIAYMRQVIVQPALIPPLAIPNVPYASPSLPPKVQMISPSKPYYELPAGLMTLVQHHVYYKPINPSTIKVPFPPPEPTKEVLDAIQEFYSGLDLLTKEVDPIFDDKVSQTIDPQGWQKGYLDNYYEKTVTQRKEWEEEQRRKEEEAERDRRHHNDHRTKRSRSRGRSPTYRSRSRDYHRSRSPSYSSYDSRGRSRSYTRRKRSRSRTRYRSRSPYRSPSRRHRHYSRSPPPSYHRRSPQQHHYKPVPPPVAPIVPTSSLNVPPPPPKHLGLGNQTVDEFAAFRRNKSESYSRREPPPPLICYKCGKVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYV1</accession>
    <name>A0A367JYV1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000500">
        <property type="protein sequence ID" value="RCH95113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYV1"/>
    <dbReference type="OrthoDB" id="2288255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="36738" checksum="59E597724B9E98BF" modified="2018-11-07" version="1">MLLLVKESSYEHPVHSLIMDPTDKVWKNYFTDAELKEILMHDIKQLPDLSEEMEEILQQFEFQGKTALEFYEFADNIKAHPINEFNKKWTKESIKSACELFFGCEELVLDDCSESDLLHSVWEFMHRLYQQKGIKAKLGERVSKAVSSAKNAGRAIKAIERRLRKAMGAKLDILFKAGIHELGSCEVGKHGVDESDDKYINDGLLKLPKTLRDMLAVQIRSNPSKINDLVAVGYLMMGLSMELVVMNVPKGKHIARVTRTEKFPFPSTMESFSADFLSLLELAWKGHEMMKKNLAALNRRKRKAAVLVTGDEESVILAPSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZN2</accession>
    <name>A0A367JZN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000471">
        <property type="protein sequence ID" value="RCH95403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZN2"/>
    <dbReference type="STRING" id="86630.A0A367JZN2"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="60474" checksum="D39E19C0A8FC48DA" modified="2018-11-07" version="1">MTTLLLLYCAASPSKDSRSSSVELNSKSRLRLAFKKYSLQKKSITCATMGAFGHLIFSSCVLLTQALNSTVACYLILYGSIVGFYTWIFAFCTRAYRLRYLFQLNQFKVKYSRMSEEERLTCLKDKNYRWYVTHSQKDLTRVLRIPYLVYALSLVIILIITIPSNLHAVHTLNSCSTIWGASVLLGMFGFFIAFLSPLIIYCLKNNPDAHGIRTELWIITFFGFPLFLLYALFFFKISPVQVDPTKYMTRVFAPANWVVFFTSIGHIVSVVVPLLQYMPIRMPCIRYIVFIKRRRAYANSSTENFDISQLAPRPTSSMSAPLELTMESLERALADPDLMHQLQDLAIRDFSSENLLFYEKYLNLVDRLKTEWSIPSVSYRFDKSSLAENDYGGILHRHIPDKLLPDFIDFYEQFIRVNAPFQVNISYKARNTLDEAFDKLYRKNPSLMPCRRNTIRVNDRVYDTHMFPLGNMHTSPTSRNNSSTSYKKDTSTAITLALFETARVEVCWNVFNSVYPKLIEIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0D1</accession>
    <name>A0A367K0D1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CU097_010900</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01000444">
        <property type="protein sequence ID" value="RCH95664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0D1"/>
    <dbReference type="STRING" id="86630.A0A367K0D1"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH95664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="464" mass="53811" checksum="1E2E5347F542614B" modified="2018-11-07" version="1">MAAKKSVPTVKQELTDLDVKVDNQINVEFGGPIGVTLMMLGFPSLMYYFWVCLEYHQGHLILPDINNLSTWFTNEIIEKIKLGASPSWYAFKVYMGYVAFSFVLAYIMPGPIVEGLPVPSLKGNKLKYLCNGLSSWYLTLVVSALLHVTDLFRLTTIIDHFGELMTVAILWGFTMSTVVYGWSVLTGNTHRMSGNFLYDYFMGACLNPRIGHVDLKMWAEIRVPWPVLFYLSLSCLLKQYETYGTVTVPMVFMVLAHFLYVNACQKGEECIPVSWDIFYEKDGFMLIFWNMAGVPFTYCYSSIYLMKYQLSTGHPISHSIPYTTFIYLLLLTGYYVFDTGNSQKNRFRMEQHGTLIKRNAFPQLPWGYLKNPTYIKTEHGNLLLTSGWWGLARKPHYTADLMMSLSWGLITGFSSFLPYFYFTFFLCVLTHRARRDMERCANKYGKDWERYCERVPYIFIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0Q7</accession>
    <name>A0A367K0Q7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">THR4_1</name>
        <name evidence="12" type="ORF">CU097_004215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000462">
        <property type="protein sequence ID" value="RCH95481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0Q7"/>
    <dbReference type="STRING" id="86630.A0A367K0Q7"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="102"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH95481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="59908" checksum="39C8661910088539" modified="2018-11-07" version="1">MKYRSTRGQAKNYSFEEAVMTGLAPDGGLFIPQAIPKLPDNWRQDWSQYTFQQLAASILSLYIDSSEIPREDLETLINRSYSTFRSSDVTPLAKIKDGFHVLELFHGPTFAFKDVALQFVGNLFEYFLERRNRQEPAGGKTHRLTVVGATSGDTGSAAIYGLRNKKNVSVFILHPRGRVSPIQEAQMTTVLDANVHNLAVEGTFDDCQDIVKVLFGNKEFNNRHHLGAVNSINWARILAQTVYYFQAYFSLLRSLNIDPASPEAESIKFDFSVPTGNFGDVLAGYYAYRMGLPINKLLIATNENDILYRFFRSHAYEKQTGSDGAVKATLSPAMDILVSSNFERLLWYLARETEADEGQTENEELCDKAGQTVAGWMQELKEKGVFKVSDQAVIKARQIFDASRVTDEETSATIRAYYEPTDKQVKPYVLDPHTAVGVAAANEFIEREQVKTYPNGSHTLICLATAHPAKFSEAVENALKSNPHFNFEKDILPSEFVGLLDKERRVTFVERPEPQLVMNVIENELRKEGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0S7</accession>
    <name>A0A367K0S7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000430">
        <property type="protein sequence ID" value="RCH95804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0S7"/>
    <dbReference type="STRING" id="86630.A0A367K0S7"/>
    <dbReference type="OrthoDB" id="5205528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09171">
        <property type="entry name" value="PLDc_vPLD6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="374" mass="42236" checksum="42DDF6D11681D669" modified="2018-11-07" version="1">MDQLYQLFCIPKPPALSIKDFKDNNFNAFLDKSMRCAHSISSDAELKQEATQHIKRLISNKSNSPSNTLRTVNTIFESASKACHFDRERALVEWMQVCVVSAVESALNGDKYPMSEKPVFEKPVKEEKKNQRIHDDDDLSWREEEEDFEDEFGDSDDDYVPPKVDDDDVNAIVPVKDTPKKKQSPRKKKNGDQLVPSNETALSVVKEGAGAKAIHKYFLDMTSSNSLPNGYFAKAFFFPSKESFKAFISVLNSATKTLDICVFAFTDDDIANALIAAKKRKVAIRIITDNQQAAGKGADAKRLSESYGIPFKTDHTQGYMHNKFVIVDGQTLVNGSFNWSKGARFKNRENVLITNIPLCIQEFQAQFDALWKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K128</accession>
    <name>A0A367K128_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WDR89</name>
        <name evidence="4" type="ORF">CU097_011857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000420">
        <property type="protein sequence ID" value="RCH95913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K128"/>
    <dbReference type="STRING" id="86630.A0A367K128"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="334" mass="37551" checksum="D299B1FC1625E783" modified="2018-11-07" version="1">MSTIDVQTCTNILPPFQLIKNIELGYNDGYVFDVTANSQYAITSASDNFIRLYDLATLQLAQTIRSHDCKISQMKLKSDQYLFTVSEDSTLKRWDLRTSSGPVQCFKYKKPLTAFDINCNDTMAIAGTELSFDDHSVDLAFFDTRHTSLLHTFTESHNDDITEIRSHPTLPAQFLSCSTDGLINNYDVTDFDEEEALISVVNSGSSVSKTGYFGPEAEYLYCMTHIETFSLHTLEGDLICDYGDIRSIGLTKVDYAIDCSYDPISRRFYLITGSIEGIVDFFHVNLGQLQHCQQLNAGNYGHSDIVRSLFWNHSTQSILTGGEDGRLCAWQGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1X9</accession>
    <name>A0A367K1X9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TAF13</name>
        <name evidence="7" type="ORF">CU097_011073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000391">
        <property type="protein sequence ID" value="RCH96214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1X9"/>
    <dbReference type="STRING" id="86630.A0A367K1X9"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="119" mass="13588" checksum="A53AA816916E8737" modified="2018-11-07" version="1">MSEQRETGYGPGRRKAVRKGMFSKDLKLLMYGFGDVANPASDSIAVMDDLVIDYISEMCQKAAEVADNRGKVKVEDFKFVLRKDAKKLARVEELLYMSEDIRRAKQLFDEKEMDPADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K504</accession>
    <name>A0A367K504_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TMEM62_3</name>
        <name evidence="5" type="ORF">CU097_012755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000285">
        <property type="protein sequence ID" value="RCH97342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K504"/>
    <dbReference type="STRING" id="86630.A0A367K504"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="3">
        <location>
            <begin position="362"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="4">
        <location>
            <begin position="496"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123670" checksum="85F52DC1A33EDB73" modified="2018-11-07" version="1">MNKSAFIYIVFIILSFIRSFQLYWTSTRELRSTTKRQWLPTNRTKSLPLLPRNDTIIIKNEPNELFYFIHVTDLHLSRYRAKGHTSHFLHFIQSILPVIKPEFVVVTGDLTDAKDRKRITSQQYLDEWNVYQQAINEKVRVDWFDIRGNHDCFDLPSWKSRINYYRTHGQSASLVEQGKGIYTWQVNKQIGNYQFVAIDACPKRGPSRPLNFFGYLTSKTMDRLEKALTWKQFNHTFVFSHYPTTTMVFGVSNKGSTFRDLAKHYSVYFCGHLHRLIAGLGDVLQSYNTVTKSLELELGDMKEHGLYRIVAVDHDLISFTDLQLPLNQIPKKISPNKHGLVYPMIQDGNATKIVWPEPIHPSPSILITNPKDARYSIPSKEPLWRIQSSTHIRFLIFSELEDPIQLKVSVYIDGNPHPHEATFVQDKLWTAPWNTSLLDPRTHHTLTIRAETPDGVKGASTVLFRVDGQRMNIGGGPGEFIIKSHMSSFLQFVTFLCIMALLVVLILPKFFGPSQDMQVKQHTTNLLLAIHTINASRPSIYSRLKRQALVWTYRFLQLPSDQPALWYASFAYILYLMVGPWFRAEFIPSAEHPRDRYGTFYMWGMTFGQEWVPIADTWMFAAEQIFFDVFVFFILLVWQGADDVCCTIFSSSNNRALNQNAWFRGLEAVYWLWRSSELVALASFYGGIWPTLVQNVCIYWMMLIGGFLAFGRNGILRKKKLHNMMRLEDCIGCQGNQRSSFKSPSTTEIVTLIKADGTMCINSTTTGTAATTTMMQYIQDKEDVLLVDHQQISMNSGCSSGNSSSTPFDGQMKSRKKISKAWFGFDQFIPEATVTSYWMSSKAFFIIRFIITLYSTIVIWTYIGVTGPYMKYFFDMFTHLTFIGLHAYLVTSTVYHFRYLHSKSLDFYFNQFTILNYLYVYLYHTVITFNIVTPVVYWSILHGSATSGVSAWINTSVHGVSFFLMIFDVILGRQKVFIRMILPVLFTVILYMCMTFIIHVTQGFWVYPFLDWSQGGRAAIWYVAVGLIVVASFFIQWLIHFVRDFVARKTGKQGHAGQVDAQSKLETSLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5T2</accession>
    <name>A0A367K5T2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000272">
        <property type="protein sequence ID" value="RCH97499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5T2"/>
    <dbReference type="STRING" id="86630.A0A367K5T2"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017034309" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="49"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="265" mass="29672" checksum="5CD1C9AFDC885DFD" modified="2018-11-07" version="1">MLFFSLLVYVLVLSVKAGVINIRDEKPICRSYHTDFTKSIDGWTEVRGATRTWEMTPEGLKLKLLRPERFTRLIDSSSSKKLAYNDAEGEGATFNASTYMLYGRFSVTLKSAKVGGAVTAMILIADDKDEIDYELLGEGNGLNEQVQTNYFWGKNIVYGKNGGEHEVDGSISSEFHTYEIDWSPEQIKWSVNGKIIRTKSRQEANGEYPTSPARVQIGLWDGSRQSGTADWAHGPIEWNGLGNEITATIKSVEIECNPEHNIIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5X0</accession>
    <name>A0A367K5X0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000269">
        <property type="protein sequence ID" value="RCH97539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5X0"/>
    <dbReference type="STRING" id="86630.A0A367K5X0"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48266" checksum="CAC4752CD8790898" modified="2018-11-07" version="1">MLAIKNKLKSSASSIKSARSNNQQYFMNNSTPVLSPRVSNASCSTSTSGSTTSLPNMPPTPPTHIVSTSDIFLNHTHLKPGNNAELLDYEKTINMYRENAKHINDPNIQWDLATYLYESSKATGNKVYMQEAIKILKSLSLKGHGEAQYYLANIYASGNLSKSHKPNFNHAFPLFVQAAKHQHPDAAYRTAKCYEDGLGCLKNKSKAYQYYRLAATLNHPGAMYRLGLAELNGDLGLKRNVRGGNKWLKRSADAATPEYPHALHELGLLHEKGLDDIIFKDPKYSVQLYAKAAELGYAPSAYRLGQCFEYGYLGCPKDSVTSVYYYTIAAKRGHPDAAFALSAWYLVGDGDRLQVSEEKALEWARLSAEKGLPKAEFALGYFAEMGIGRPKDLNEAMVWYKKAADHGNEKAIRRLKEKAPLNINKNLPAVATEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6M9</accession>
    <name>A0A367K6M9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000248">
        <property type="protein sequence ID" value="RCH97789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6M9"/>
    <dbReference type="STRING" id="86630.A0A367K6M9"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="13812" checksum="0C00CCFD204FC2FF" modified="2018-11-07" version="1">MSTDKSFCAYRMALRASKGSGIPYLGIHTQDLVSLAEANKDFRPDGTVHWDKYRLMGETIMSIMKFKHPGYKIDPDLPLLLSIADCPVLSEDELYKKSILVEPKVNTNPNSRLKELWLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6P2</accession>
    <name>A0A367K6P2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000245">
        <property type="protein sequence ID" value="RCH97826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6P2"/>
    <dbReference type="STRING" id="86630.A0A367K6P2"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="415" mass="46456" checksum="F72C8058B903ABC0" modified="2018-11-07" version="1">MNEEKPAYGTIEKVALKFMSELSFTYKIFFGPDPNKVRPKVLLLLAGLAVVNIVIWVISVIVFKPYPSMLGTGTLAYLLGLRHAVDADHISAIDNVTRKLLSSGQHPVCVGLFFSLGHSTVVFITSIIVAATANAVAKNVDDFSKIGGIIGTSVSITFLVLIAILNIICMIGVIKTMRRVKKEGIYTEVDIEEYLTNKGVLGRFFYPVFKFINASWKMYPLGFLFGLGFDTASEITLLGITAVQGANGMSMWFIILLPLLFASGMALIDSLDSMLMLFTYTWAYVNPVRKLFYNLTITSISVVVAIVVALIELFSMIGEQLELYNGWWRFWYFLSDSFEYIGIIIVSAFIITWVVSAIIYRLAGYRQLEREFDTYDPERIRKTALSDERLKVTDEKDKAPDATEMTKKSDISEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6Y0</accession>
    <name>A0A367K6Y0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">APC5</name>
        <name evidence="11" type="ORF">CU097_014194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000233">
        <property type="protein sequence ID" value="RCH97983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6Y0"/>
    <dbReference type="STRING" id="86630.A0A367K6Y0"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SCP2" evidence="9">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="330"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH97983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="689" mass="80000" checksum="624FC2B9F78A17E4" modified="2018-11-07" version="1">MTENNNKQPLVADVLLPEIEKQLIQDDSLWPNIKGLYVIHVTKKKQPVATWYLLLQGNTVQPIITTHKDMIKRAKVFKVKTIKIQVEDHDLLNFITGGLTGVKAYMAGRIKVRGDLVLAQKLEEVFEKAGGRENESRCEETCSEPTLRQVIATIETFTDDDNIITYTVEDIVNDINALRRPERLESFLKSNENDINLRDVGSHTLDTYIDITSLLDNEAEIQSQDHILLQKECVFGLFIRKCHVEFESMPDDRFYDLFRAFDMYCSHQAGDNIFTDQQEERWISEHNIVTFLRAQAEMIEKTGQSSIHPTVMHNYLRELEQCVPDVPYIHQMKYLNYALSKEHVQSLYHLHIYFDSSVNQGVEIQYALLNLGILEYKFGHFSDALFAFNDALTAARKNKDEYCLQEIQYWIETCRKNHYFQGSSSFTDDYLNNMKALTLARDMICRGDSNKHVFEILYKTSINIIMKDIEQMDRVQYLITALAWLRCGNSTLVSSYLELAKNVKDSRIEDIEKTVLLNAKMLELAGESEMAIDLIDMFTRQYPKESVLLMDWKITRANLLKQTNNRKREFESALGILDRIQEQIQKRDKASGLDTLLVMKAETYIQMGYHNGAIPILQKAMTQSKLAYNTRNFYIAVIKLVRIYIRSKNADLKRKAIIMLERVFPKVLLMKSKDLELDLRRTYAEATSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7T0</accession>
    <name>A0A367K7T0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000213">
        <property type="protein sequence ID" value="RCH98227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7T0"/>
    <dbReference type="OrthoDB" id="2233065at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="31062" checksum="FDB11CFE970C7032" modified="2018-11-07" version="1" fragment="single">MRENEYSELLSQALNETMAPVQSIVNEAFMERLVKYSQSAKQLYKIYPLVMVFCIDKLSLLTLITKFIPVDGKPWMQRILCCDFWAKKCYLVSKSSLSCEEVDANISPLQALSMVLIEQSPTLYGHSLPEHSTVQTLYRLVMECTAYEAEQREDLAHVVGVICSNNKKFAEGHDALNVEFARCADDTKYGEDRRKILRESKNNGDYVYRAACVKKKLKKELKSLGIQIADNEGEITKTRLEDESFRSESASRLVRALRRSKEKCCTHQQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8E1</accession>
    <name>A0A367K8E1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000193">
        <property type="protein sequence ID" value="RCH98493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8E1"/>
    <dbReference type="OrthoDB" id="2277294at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="26127" checksum="665F628C3BC1D974" modified="2018-11-07" version="1">MEWKKKAIEYEAAYNEAKQQLEERERFLMKRHQAEIEALTKAQVDQTNENLDLLLKLENENKQLKQQLQNNPTKEEQQLPIPPLAPFVSNTSQLCNTAEVANQTATASVMKSRKQSDELVERINVSLLLNFIKTRLTRCQKEMMNAMEGTLHGIKDSYGQTVMENATPPLISDLSSSEEEYDAQSIEIIPKATSSKKRLSSFFFGSKHKKDDMFVEKKKAVFKVPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8R9</accession>
    <name>A0A367K8R9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SUR1_2</name>
        <name evidence="13" type="ORF">CU097_012224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000186">
        <property type="protein sequence ID" value="RCH98578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8R9"/>
    <dbReference type="STRING" id="86630.A0A367K8R9"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF110">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH98578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="330" mass="38384" checksum="88E2F54BE5586AC3" modified="2018-11-07" version="1">MSNEQQQHHHHSRLFYFLTDPSKLSSLINPSQSGNAHQHPLPLPSLPTTTTPIAVAAVQDCCNQCCRTIPTEQQQQQQQQQQQPISTEPVQCKWSSCLQSFTQPEDLAPHLFKDHVNKNRKKQLKCYWESCSETVEDLLKHLTSQHLMGLWLACRWINCNKRFEGFSTLTNHVSEDHVGSGKSEYQCYWVSCDRQGKVFTQRQKIMRHIQTHTGAKPYQCQVCQKRFSESNVMMQHMRTHTGEKPYRCQDCNKQFTVSASLTIHKRVHTGEKPFACKYQNCNRRFIESSNLTKHMRVHTGERPFKCTVKLCEKAFSRSDQVARHLKTHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9H1</accession>
    <name>A0A367K9H1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell death-inducing p53 target 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDIP1</name>
        <name evidence="8" type="ORF">CU097_014016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000165">
        <property type="protein sequence ID" value="RCH98864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9H1"/>
    <dbReference type="STRING" id="86630.A0A367K9H1"/>
    <dbReference type="OrthoDB" id="4713066at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098560">
        <property type="term" value="C:cytoplasmic side of late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF46">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="7">
        <location>
            <begin position="85"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="183" mass="20410" checksum="055E4DE22C61C030" modified="2018-11-07" version="1">MSQIPPHRINNPHFEQPPQSPINPTLYPKPPYISQNTYASMPQNTVPNYSPPLMTMPLAQPVMPQAPYYGALQPPIERPPQLGVPSDMTIQSVDSLTTKPAVVECQHCRQLVLTVVDYDVGLLTGLSMVGLYMLGCHSGGCLIPYLFPWTKDVVHSCPACKEKIATFTRLERDTHVHATYDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAP6</accession>
    <name>A0A367KAP6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000133">
        <property type="protein sequence ID" value="RCH99285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAP6"/>
    <dbReference type="OrthoDB" id="1721053at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="128" mass="14421" checksum="F6417515B812C6C4" modified="2018-11-07" version="1">MGLIFNRTLNRHWSAGRIYQGVERIILKELGKITPVHIDGLVWHLDVDSSHPGGVGAPKGSAVRRVKWYVSWVKYVVRQYGSYLLMELESDKNLALVREDRVCYSTAGKLRSERITADSVLSGKPILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB62</accession>
    <name>A0A367KB62_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000129">
        <property type="protein sequence ID" value="RCH99349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB62"/>
    <dbReference type="STRING" id="86630.A0A367KB62"/>
    <dbReference type="OrthoDB" id="2287482at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="36666" checksum="F8CF32246FCB2CA9" modified="2018-11-07" version="1">MSVTLSSFTRSDPVSIPTSNNKNTDNEQSYKDMIKQLAAQAPEPYGAIPPLKRKQKKKRPKETAIRRLSYVENWLAVDSKESIPDEEDLKPSSPFRNFLSTDFLVLPLHMPPPSLSAQNEELPIYDSRPSSEIDLLHMEEVEEEDDEDEEEDDEIEYDIPDEQQRPKTLTKQRSIPSFSKSVRPSTSTTKSYAMSSSPPHQEESSSWIETLRRSLVLSTSPRQTKQLIPMPLPPPKPRMRKRRSEATTQPRFNPETNTYTRDTRSNPDHLRMISAELNMMRARKLSSPLKPRGFLPRRTDVFIRGENRRKSLLCNEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBH3</accession>
    <name>A0A367KBH3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NHX1_2</name>
        <name evidence="13" type="ORF">CU097_014716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000122">
        <property type="protein sequence ID" value="RCH99459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBH3"/>
    <dbReference type="STRING" id="86630.A0A367KBH3"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="38"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH99459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="605" mass="67355" checksum="44488371EDBB40C5" modified="2018-11-07" version="1">MDPDNTTVPGDQPMEEEMYSSWALLIFMTLLMGALWTSYFLQLRKIRAVHETVISIMAGMIVGLVIKLAPGTIIQGMVKFKEGVFFNLLLPPIILNSGYELKRRNFFLNFGTILIFAMVGTFICAIVTGVLTFIYALINPEGLNISFLDSMIYGSILSATDPVTILAIFNQLHVDPQLFSIISGESLLNDAVAIVLSDTLRHFRGQELHAVNILKGIGLFLGVFWASTLIGIVCGVLVALIMKFSQLHKFPNIEACFVLLMAYSSYFFSNAIQMSGIVTLLFTGITLKHYAYDNLSLKSKRATKSMCQILSQLSENFIFIYLGVNLFTQDDLDYKPLFIIITLAFICIARYASVAPLSILINAVCRALGNPEQLPRNHQIMLFWAGLRGAVAFALASGITGESAPAMRTTILAVVVLTVLLFGGTTSRMLQILDIKTGVAEPDESGSEDEEGEEDGRTGNYQRVNNFEPSTQRKRQFDENDVSIGGLLSGPLGEPIIEDRAPHWFVSFDEKWLKPALTKKHVQRNQSLAEYWKEKRRKMERANRNMLDGIRSFPFDEDQSDAVTLNSVKATTSRPSYNNRNSPKIVVGSGRMFGRSPTHESDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBK3</accession>
    <name>A0A367KBK3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of ploidy protein mob2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MOB2_2</name>
        <name evidence="2" type="ORF">CU097_014751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000112">
        <property type="protein sequence ID" value="RCH99595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBK3"/>
    <dbReference type="STRING" id="86630.A0A367KBK3"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="23492" checksum="734B60FABCB236AB" modified="2018-11-07" version="1">MMMIDSKPLFLTHPYATIMLVKGDFKTIIELPKYVDINEWLAFNTFEFFNHLNLFYGSITDFCTPQSCPTMSAGPGTEYTWTDNMTNKKIKLSAPQYIDYMTSHIESMIEDERLFPTKSGREFPADFVQIVKNIFKQLFKLFAHIYHHHFDKIISLHEEPHFNSLFAHFISFARQFDLLEKKDIQPLNELIELHTQCNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBM9</accession>
    <name>A0A367KBM9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rab32, member RAS oncoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RAB32_2</name>
        <name evidence="9" type="ORF">CU097_015282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000109">
        <property type="protein sequence ID" value="RCH99653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBM9"/>
    <dbReference type="STRING" id="86630.A0A367KBM9"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044276">
        <property type="entry name" value="CANIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14816">
        <property type="entry name" value="CANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil SMC6 And NSE5 INteracting (CANIN)" evidence="8">
        <location>
            <begin position="178"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="731" mass="84572" checksum="B44E81606B4E667B" modified="2018-11-07" version="1">MSSGFKKPVKRSRRRLVQHDDSDTGQQVTTVEELVQRKKNKIEREKTLESLFQELEQERINQEEVDIYGYPIQQTPNKDLISIADVQFDDNYIMESYTEEMEQEGLEIKDQVKDYLAPEEQEHLDNVFQAIKETEEIHRLEKDWNRPFFKDGIKCIREPCLISRDLFCGQKEIHLSELSATTEGRSFLLASGCMKDWHNSGWKCPHYVYQWLFEVVALDQDKATARNALSTLLMLWSHPDDRNESESREIYEQRYIKLDVFKSVLTAYHAIPTELVDVISMDTEDQMMTETIPIDSQHRSRHIPLSQLGLMIKAFGFSIRLWKEAYMPWEIRYTIRILLQLSLDKAGHLVIQEIQTSIDNCLSALKETWKIDVKNIANDICDMVTTPKQQMHLLDTLKTVYDRSRYLRRVIGITCLGRYLERDVPGSMDNIPVDESLIKQAALMFSYPEKPFTRSNLDYDEYCIRIAMLDAAIGTDDDEIRRERETIIQIADELRLIGLQIGAKLGVMKKTIANEMVQRTEMKEYLFKILVVGDLGTGKTSIIRRYVHNIFSTNYKSTIGVDFALKVIQWTPDIIVRLQLWDIAGQERFGNMTRVYYKEALGAIVVYDMTRPQTFEGVTRWKKDIDAKVALPDAWGGGQIPVILLANKTDLIQEGHGQPVNPAELDSFCREHGFIQWFETSAKDNSNIEEATRCLVSAIVKLEEENVNNTVSDEVSVKLGQQQRQQNNGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBR9</accession>
    <name>A0A367KBR9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000106">
        <property type="protein sequence ID" value="RCH99693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBR9"/>
    <dbReference type="OrthoDB" id="2289409at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="113" mass="12873" checksum="517C39F4ADB51FE8" modified="2018-11-07" version="1" fragment="single">GIDSEDNVQVVLNDEVKKQSSIVAFATMMSEQITQFLIRITENMESVRKAAAAEGITERSAYRYKKQWNEFGTVIRLKRSRKIGTVSQLKDEHGDFLIRLVDKKAEITIAAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBW0</accession>
    <name>A0A367KBW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NMT2_2</name>
        <name evidence="11" type="ORF">CU097_014883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 6"/>
    <dbReference type="EMBL" id="PJQL01000110">
        <property type="protein sequence ID" value="RCH99630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBW0"/>
    <dbReference type="STRING" id="86630.A0A367KBW0"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000003">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="9">
        <location>
            <begin position="96"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="10">
        <location>
            <begin position="269"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="473" mass="54976" checksum="E6238F3EF4B7C126" modified="2018-11-07" version="1">MADKRGPTEKELQDLAKKVDKLVKKTEKLKSTSAPSSTPSSSQEATLQQLRQMMKDMAMLEQSDPTMAGRKSMTDHKFWNTQPVPSHDEHITESGPIEPDIPYDQIRKEPLPLPKEFEWCEVDMADEKQLKELYELLSLNYVEDDEAQFRFDYSAEFLKWALQPPNWKQSWLVGVRVAANKKLVAFISGIPVALRTYEHVHHLVEINFLCVHKKLRSKRLAPVLIKEVTRRVHLENIFQAVYTAGAVLPKPVSTCRYYHRSLNPKKLVECNFSRIPARSTLSRMIKQFKLPEQTSTPNLREMREEDVPQVRELLNQYLSRFDFAPIFETDEDVKHWILPHDKVVWSYVVQDPETKKITDCFSFYSLPSSVIGNPKHNTLNAAYMFYYAIDLSAYEDKDKQHKYIKKRLNELAHDALILAKKADFDVMNTLNLMDNACFVDEQKFGKGDGFLNYYLYNWKCPDVTQSKVGLVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCS8</accession>
    <name>A0A367KCS8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000087">
        <property type="protein sequence ID" value="RCH99987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCS8"/>
    <dbReference type="STRING" id="86630.A0A367KCS8"/>
    <dbReference type="OrthoDB" id="2266739at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="16720" checksum="8FC307CEAB46974D" modified="2018-11-07" version="1">MFVCAFRAQKVKAFVSSCGTTRLSGEKTFKSSDGNLVTIKYPEIVDEYKRHKSSSVDAANNLRDNLTSYHDIISTGRRTLSLFRITNKLESCWELSDLGLVSESIDCREREEKNKVGDCDSGCSVKTETNKVQKETNPPSTMFISSCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDK5</accession>
    <name>A0A367KDK5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate synthase</fullName>
                <shortName evidence="23">DHQS</shortName>
                <ecNumber evidence="23">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="23">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="23">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="23">EPSP synthase</shortName>
                <shortName evidence="23">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate kinase</fullName>
                <shortName evidence="23">SK</shortName>
                <ecNumber evidence="23">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="23">3-dehydroquinase</shortName>
                <ecNumber evidence="23">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="23">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="30" type="primary">ARO1_3</name>
        <name evidence="30" type="ORF">CU097_013050</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22 23">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 23">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 23">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 23">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="23"/>
    <dbReference type="EC" id="2.5.1.19" evidence="23"/>
    <dbReference type="EC" id="2.7.1.71" evidence="23"/>
    <dbReference type="EC" id="4.2.1.10" evidence="23"/>
    <dbReference type="EC" id="1.1.1.25" evidence="23"/>
    <dbReference type="EMBL" id="PJQL01000069">
        <property type="protein sequence ID" value="RCI00286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KDK5"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 23" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="18 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 23" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 23" id="KW-0521">NADP</keyword>
    <keyword evidence="11 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 23" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="27">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="29">
        <location>
            <begin position="197"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="25">
        <location>
            <begin position="425"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="28">
        <location>
            <begin position="1329"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="26">
        <location>
            <begin position="1451"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="23">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="23">
        <location>
            <begin position="1324"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1726"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1771"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2068"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1735"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2126"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="23">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="23">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="23">
        <location>
            <position position="843"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="23">
        <location>
            <position position="1217"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="23">
        <location>
            <position position="1245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="897"/>
            <end position="904"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="RCI00286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2164" mass="239835" checksum="0C0EDBBBB554D706" modified="2018-11-07" version="1">MTPKEPDVVKVPILGSESIIVGFHLTEYLIRDVLTNISASNYVLITDSNLASIYLDKYVQVFKSVSDELFVSKGLQAPRLFTRALPPGEMTKSRKIKADIEDWLLSNAVTRDTCFLAMGGGVIGDLIGFVAATFMRGVPFVQIPTTLLAMVDSSIGGKTAIDVPAGKNLIGAFWQPKRIFIDIDFLRTLPEREFSNGMAELIKTAAISNEDDFCKLENGVEAIRDAVLNSNNSNIANQGQTLETRTPQQSLLMDVILASVRFKAFVVTNDEREGGLRGLLNFGHSIGHGIEAIVSPMMLHGECVSIGCIKEAELARNLGYLNQVAVGRLARCFASYGLPISLDDKKVKERIGNLHCHVDDIMEIMKVDKKNQGDKKRIVMLSAIGKTLEPRASVIADPDIHKVLAPEQLVLPVTESATGPKKEVTLTTPGSKSISNRALLIAALGKGTVRIKNLLHSDDTQYMLAALKGLNAAEFEWEDNGETLVVHGGGGRLVVPDKELYVGNAGTASRFLTSVLTMIPTNEGAKNTAAVLTGNARMKQRPIAPLLDALKANDAQIISLEKDGFLPIAVTPNGGFKGGRIELAASISSQYVSSILLCAPYAKEPVELVLVGGQVISQPYIDMTIAMMESFGATVERLPENTYRIKQATYQNPDTYLVESDASSATYPLAIAAITGTTCTVSSIGSSSLQGDAGFAVNVLRPMGCTVVQTETATTVTGPPIGQLRPLPSIDMETMTDAFLTATVLAAVTSSDGKTENITRITGIANQRVKECNRIAAMVHELTKFGVQASELPDGIQIHGKPIKDLKAPKEGVHTYDDHRIAMSFSVLSTVVPHGTIITDKKCVEKTWPTWWDDLERKLGVRLNGIDLGVRLANKSTLGRNKPTSKTDQSQSLVIVGMRGAGKTTLGQYAAKVLGFNFIDVDQHFEQTLNTTITEFINTWGWDQFRLKETEILKQLLDSPYARQHVISCGGGIIETAESREVLKKHHMNGGKVLHLVRDLAQVVNYLNRDQTRPMFGEDMMTVWRRRRQWYKEVCNYEFVAYAASLTDRGFVDPPEWEAIKKDLKRFLWFIYGRNTNHVDISPNIESPTTFVSLTSKNLATCVDSLKEVCEGADAVELRVDLLQKPDDKEELSPIEYVGEQLALLRRAVSIPVIFTVRSKGQAGAFPNDDEEGMFELLRWGQRWGCEYIDVEMCWSTNKIESLVASKGQSRIISSWHDLQKITPWDSTAIEAKYELGTKYGDIVKLVGVAETMQDNFKLEAFRATKQDKNLIAINMGVVGQLSRILNDCLTPVTHPALPKKAAPGQLSLAEINQARHLLGILPAKSFWLIGTPIQHSMSPTLHNTGFQTLGLPYTYGLLECHMVEYAEEAILNDPHFGGASVTIPHKVSIMKYLDQVSEDAKIIGAVNTIYVRQTTVNGEKKRLLLGENTDYLGMKHCIQALMMDPDHPPQQGLVIGAGGTARAALYTMQQMGIQKIYLWNRTVSKAYDLQQAFKGKIEIEVIESLEANIGPGVIISTVPADSGIELPEHLYGGIKGIICDMAYKPRRTKLLLQAEEKGWSCVEGIEVLIAQGIAQFEIWTEMKVLSQLLGTYSKHKKPLILFRLPDTDTLFYRLSDIVPLFDLPTISFKEGNYENCYRDHEDTYLNTKVLSELALKHNRYMLAELCKFKPDDYQKGLVDAILQTFPDFTRAPKEEHIWESVQLPLENFQDVIEREGEIAIKAEPQSPPSIHQATTNTTTTTGNNIPETRNAMALDKVLLSSNELKRQSMIDQANKRQRISGTSPGQQSDDKRTVASSSTRQLARKIHSYPAGEAEQHSSNKKRLSIKHKNALNLTIFAPSYHEQLAGIRSAPINSNFSQAVLQQQAHHQKSGLGRTNGIHTTQHNVPIAPAPASATVARPAFAHQPSPRRQEFAIPPIVPSQQQPPHSAHPTSRENLTYQQYSASYNSKHYNTQRNLEPIAVSAANVPLPPKTPTTSSFAALQRQQYLQPFEHLFDTIETTRTLKSTLDDQIRRSSSLMQTLQASATTIEGLVRNQVKEAQWEFVSQFEKKVDELLRRIEAVEHRMSETVERQQQQQQQQSNHLEPRSSANHSLPSPLPSATREERAVAEDLVAMSEKRQEQDELQTPPTIVRSQNDIGPHEYQTMLNTLRDRLDRLERQIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDW0</accession>
    <name>A0A367KDW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000064">
        <property type="protein sequence ID" value="RCI00379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDW0"/>
    <dbReference type="STRING" id="86630.A0A367KDW0"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02972">
        <property type="entry name" value="DsbA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="200" mass="22742" checksum="6E3388836DD9EE06" modified="2018-11-07" version="1">MALAPQFAGHRLGSALAPHTIELYLDYVCPFSAKLYKKIREQVWPYIEQTYPNKVKLIFRHQVQPWHAASTAVHEAALAVEKLDDNKFFPFSDVLFLRQKEFFDESLETKSRRQIIEELAQIAETIGVSSDKVLNLLTNGSGEPKNAGNKVSNDLKLQVKLGRQNGIHVSPTVLFDGLRDDSVSSGWELDQWKEYLKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE23</accession>
    <name>A0A367KE23_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000065">
        <property type="protein sequence ID" value="RCI00360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE23"/>
    <dbReference type="STRING" id="86630.A0A367KE23"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="396" mass="45004" checksum="B127D189682CD345" modified="2018-11-07" version="1">MSNSPSPSTSKRKSHIVVETLGATTSETEEGLRKINNYLLKKEIGRGAFGTVHLGIDEITKKEYAIKEFSKSRLRKKEQMDQFRRSGPRRRLAGLGVNRQQAVKGTENPLDLVRGEIAILKKLDHPHVVRLFEVLDDPSGDSLYMVFEMMHKGVLMNIEADQVATPYSVDVARRYFKEMMLGIEYLHANDIVHRDIKPDNLLISKDDVLKIVDFGVSEMFVKGNDRLKKSAGSPAFMAPELCVARHGEVSGKAADIWSMGVTLYCLIYGKTPFMSSNIIELYEQIKEAPIEHGDDIDVNLRDLFERILDRNPETRITMKELRNHPWVTNDGTETMISEEDNCNIVSDVTDEEMKNAIKSIASLYVVMKAVSKFKRHSRSLSQQQTELHEKLQDLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFZ8</accession>
    <name>A0A367KFZ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc transporter msc2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_013047</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000023">
        <property type="protein sequence ID" value="RCI01145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFZ8"/>
    <dbReference type="STRING" id="86630.A0A367KFZ8"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000016">
        <property type="entry name" value="Zinc transporter ZitB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="14">
        <location>
            <begin position="230"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI01145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40814" checksum="41F84BD3E63A4AD0" modified="2018-11-07" version="1">MLSRKNKIYFMLVITTCFFFVEIVIGYYVSSLALIADSFHMLNDLLSMCIALWAINVASSTKYDPRYSYGWQRAEILGALINGVFLLALCFTILIDSIERFVSPEEIKNPVMVLVTGGAGLLANVVGLFLFHDHGHSHGHSDPEKGNHSHHGGGHLNMKGIFLHVLGDALGNVGVIASALFIWLTPFSWRFYFDPLVSILITIIIFTSALPLVRQTASILLQGVPKSVPLSDVHESLVKLDGVLSVHELHVWQLSDTKLIASLHVLIESREKYMDLASQIRGLLHSFGIHSATIQPEFIDDKKIDQALSIMPKEENINQSGTLNDTSSDIASDHNSGQDLQNSSTCLLRCTEDSCLENNCCPPLQNETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGP2</accession>
    <name>A0A367KGP2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_013323</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGP2"/>
    <dbReference type="STRING" id="86630.A0A367KGP2"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="322"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI01386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="757" mass="87346" checksum="233393577EF58776" modified="2018-11-07" version="1">MSSNLRQRRVEAEIASTKHLDVDFDDSKKYGNNFSPVQNDRTFHKLAFSLLCIIATFVTFYKIWNPAEVVFDEVHFGKFAGYYLQRTYYFDVHPPLAKLMIAAVGYLLGFDGKYDFANIGDDYHDHNVPYIGLRSLPAALNVFSTALIYLIMKESGYSLIICVLSTAMYIFDNAMVTQNRLILLDSMLVFYMLATVYAYVRFRKLRHKSFSAKWWFWLLLTGIAMAMTVSVKMVGLFLVALIGFSVLYDLWNLLDINYGLTMKQFMKHFYARALALIIIPIAVYLFWFYIHFAILDQSGPGDSFMSTRFQDTLKFSPLKMAALEVHYGDVITLKHKDTNAFLHSHDLHYPLRYEDGRVSSTGQQVTGVLESNENCFWRVKPTFPIEDNGEPIPVKNGDVIQLEHIVTGTNLLTHDVASPWMPTNEEITTVPLNSRYEETLFKIIFEDDDMEVLETHMTPFRLIHEDTKVAVWVHNKKLPEWGLGHLEVNGNKNAIDNTNYWIAQEIKGKNATEINSRRNQKQLRHMPFIKKFLELQGKMISHNAGLTKPHPYQSTPITWPFMIRGVSYWSKEDTRSQIYLTGNLFGWYLSVGGIAVFAGIMVADILARRRGIEPIDEPVRHRLIQSAGFFFTAWALHYFPFFLMGRSLFLHHYLPAATLNYLLLGSMYQFIFIDGIDSPVSFITRQSNKTRLTIMKAEVSWKVYPVVLITLICQVAMFIYLAPLTYGTPMTLEEVQNHQILSGWKLQYGKSKQIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGY9</accession>
    <name>A0A367KGY9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CYR1_2</name>
        <name evidence="17" type="ORF">CU097_015907</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000010">
        <property type="protein sequence ID" value="RCI01438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KGY9"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="366"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="1125"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1441"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1675"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1683"/>
            <end position="1697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI01438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1861" mass="207589" checksum="05873D66E850D4A2" modified="2018-11-07" version="1">MNIQYPRHMHSPSWDQSNNNNNNNNGRKKDTQIANSLPNNQPTDSFFNRVFGHHSSESSRAGSPVPPPLHHQPSKQELLQKSSSRHSRNSSTGTLPISIVTPYPTAAGTEIVTAEAKMQRRRSFDGQTTDPKGLKPKPVPVASVSARVAASPIPSKGVKGTTIPFPRGGRQIGTNDDNNTSTIRRSNSIERNQFRPEEHAPKKRHFFRLVKKKTNTGTSSSASSTFTNASSSHTSSSITLTNPTPAPRKRSNDIDHKSLLDGNTPYDVQRHYYQSRDEKKKLTSSSAMDQNFDTLDGIVNPEYYKVASPHPQLAVDNGFDFESWAPPDSWGVQPTSIAANLALDEDHAEFEDYQMDVQEKWDVPKKNANIKIYRPDQTYNTLHVPLNTTTLEIFKKLANKFFMPDMTKYNLVMKRYNNERVLGLNERPVQIQKMLQEQMGYTDDDKIDDISYLIRFQLMPNVSQPIPPDDKDFGQHVDLQSRSLATIPIYLYKHASSIVSLDISKNLHIEVPIDFIQMCTRLKQLWLANNEYSMLPPSTQHISSLEHLNISGNRLRDLDHAKLDRLSELRTLRAINNQLESLPESFATSFEHLTSLFISNNSFTKFPLVICEIRSLAYLDISFNKIQMFPDEIGQLTNLIGLFAIANRITGGLPPSFLNLTKLQELDIRQNCITDLDVVSHLPRLEILLVDYNSTSIINFEIKNVKQLKMYKNHLTQFNLTSATGGHCLTELNLSNCKLSSLPEELFNNALGLERLVLDSNTLSTLPSSIGSLQKLVKLSIQNNYLDSLPSEIGKLSELRALDAQKNNLKGLPREIWLCCSLQTLNCSSNLLDSFPEPFSTTTPPNSSTAMHSSSPRKDNDTDAVLSMLPSQLNAGQGTIARIDSIQKPGIMAASNVPQTPLETSQPPNFNPPSFFASPRNHPPPLSLSLRYLYLGDNRLTDDIWSPLSLFLELRTLNLSFNDLYEIPPEGLCHQHLYELYLSGNQLTSLPADDIEKLQYLRILAVNGNKLQTLPAEIGKLRKLLVLDVGNNVLKYNIANWPYDWNWNWNLGLKYLNLSGNKRLEIQKTHPDPINPKEKDLSDFSALTRLRMLGLMDITILGVSIPEEFHDRRVRTSPSEVNGMSYGVADWLGPSDHLSTWDLVMPRFRSKEDECIFALFDGSKHPKSGCRLTKQLNDMLTSHLAKELSCIKSEDTIVSAVRRTFLSLEQSLGTSPHIDKDSGASAAVCYIAGNKLYVANAGDALAVISRNNGQAFEITQKHIPLNPSEVSRIRAAGGYVSNSGLLNNELNVSRSFGHFHLVPVVNCNPYVSTIDLSENDEFVIMASRGLWDKMSYQTAVDIARTEKDDLMAAAQKLRDFAITYGANDNLMVMVIGVGDLFDKRRKLPRKNNIGAGRGGADGVVEEGILVKSKRRGKEEIPGDSTLARLEREVAPPVSQLALVFTDIKSSTQFWETQPENMRAAIKIHDAIMRRTLRSVGGYEVKTEGDAFMVCFKNITAALLWCFTVQLQLLEADWPAGILDTEEGREIEKDGVVIYKGLSVRMGIHWGTPVSERNPITQRMDYFGPVVNKASRICNVADGGQICVSSDVIAALRNFPSMFDEDAECDETLDADEGSFPVSRDLLQLKRLGFHVVELGEVRLKGLETPESLSLVYSKQLLGRIEVDKSQMMAPAAQPTIDASLSPKPSTDDTTSTIPPTPALTSNTLSPSPDYLTVRPTARKTLRTIDPNLVCAMSNLAIRLERLTSGHVLSQSMAGSSILGHYTYQNSSEDNVPVVNAAHSGLGHMLDKHIREEATDEELMVMMENCVSRVENATSALYLQKMGRFANVLEKLGETIEVDPMHIMKALQMYAEVVSNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGZ5</accession>
    <name>A0A367KGZ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000011">
        <property type="protein sequence ID" value="RCI01411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGZ5"/>
    <dbReference type="STRING" id="86630.A0A367KGZ5"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="270" mass="28351" checksum="728013C4405A7F5F" modified="2018-11-07" version="1">MVGGKPILWDRENDWVLITGVWKALGKSKADVLKVVDANPGLPMKKIRGGRLAIQGTWLPMESARELCVKNAWPLRHELVPLFGDSFPSVCLAPSHPSFGDLKVDSVASLGVSTPSASVASVSRSSRGRARACLSLATSAPIRRSSRASSRAALTATASGAASIPPICSSGSMVTSGDRSVSVDAAASRASVPARASRARGRVSRTLPSRASKRSHPYQRDASGGSSRVADGQLYPGDSVGYFVPLPNGEIIGRAIHKESFCRRGPRGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHD6</accession>
    <name>A0A367KHD6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG6</name>
        <name evidence="11" type="ORF">CU097_015964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHD6"/>
    <dbReference type="STRING" id="86630.A0A367KHD6"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI01634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="515" mass="58905" checksum="13C71DBDCB9577CF" modified="2018-11-07" version="1">MSSDCTLLAKMRKRVVLMKDAVPHLFENSPIRRVLQHVVQNHALWTVPIIITLFALFTRWSVALNPYSGYNTPPLFGDYEAQRHWMEITLHLPFSQWYTYDLQWWGLDYPPLTAYHSWLCGLIGSKINPDWFALDKSRGIESAESKLFLRSTVVVSEFLLYIPAVMAFCQILYGANNAYLKKYTAACLILMQPALIMVDHGHFQFNNVMLGLTLWAINCFLTQRYVVGSVFFCAALGFKQMALYYAPAVFAFLLGRCFIEERGILLFIKLGITVVATFVILFAPWLRSLEDIQQVIFRVFPVARGLFEDKVANVWCAINVIVKLKQILSLESTVRLSLFATLIAILPTAIHLGLKPSRRRFLYALINSSLAFFLFSFQVHEKSILLPLLPATLLVLEEPIATTLFMNTAMFSMFPLLKREALVLPYFVVTIMWNWLAGEHNTANRGLLEKVCTKGVYGAFFIWHLAETLVEPPSHLPDLYTVINVLLSCGVFCLLFAYFSYRQFTTSFVQKAKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IM49</accession>
    <name>A0A367IM49_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004944">
        <property type="protein sequence ID" value="RCH78745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IM49"/>
    <dbReference type="OrthoDB" id="2244766at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="23328" checksum="85268B569FAB4E27" modified="2018-11-07" version="1" fragment="single">MNLDAYLLEMYQEQGHEFTLAAINDVLKQWEEANIGPTNKVYEMDGAPMTREEYAQYTVETIGAYVHALSQCQPTEYQNEDWEAIENLEIIKHLELLLGQYYDNYRAITREINGLMDKREEIAEYFAKNASHWAHLKFRKPSPSKESVALYTMAKQTQLKAIAPGYGFFRGLAIKTKQVDEWTRIEDDPTVGAGICNLLDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMT2</accession>
    <name>A0A367IMT2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Far upstream element-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FUBP1</name>
        <name evidence="5" type="ORF">CU097_000535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004809">
        <property type="protein sequence ID" value="RCH78936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMT2"/>
    <dbReference type="STRING" id="86630.A0A367IMT2"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH78936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="267" mass="28991" checksum="2F19DFFE2A4C7DD9" modified="2018-11-07" version="1" fragment="single">MEGKNYSAVPPPPSLTDKESPVNFSDALSRARAIAEKLKQTTASTTDQPQPPQQQPSSSTVYSGTKRGYEDSSPPTSHQQDDRENKRSAYDSGASRPSYVSNEPRRYGLGSEERRPTSNYGTNSGRQEEYKVPNHMVGLLIGKGGENLKKIERMSGVSKVQFAADTSGPERVVYIAGEPDQISIARDMIRQMVEDAKVTEANRSGATTAPPAGGYHHHHHHYGGAAGGNTMTIRIPVPKVGLVIGRGGETIREFEQQSRAKILLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMV6</accession>
    <name>A0A367IMV6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS6_1</name>
        <name evidence="5" type="ORF">CU097_002303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004751">
        <property type="protein sequence ID" value="RCH79022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMV6"/>
    <dbReference type="STRING" id="86630.A0A367IMV6"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH79022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="24947" checksum="F047BB4DF3098A68" modified="2018-11-07" version="1" fragment="single">RGFYDKRMAQEVSGDALGDEFKGYVFRITGGNDKQGFPMKQGVLLPHRVKLLMSKGHSCYRPRRTGERKRKSVRGCIVGPDLSVLSLVVVKQGEQDIPGLTDTTVPKRLGPKRASKIRKFFNLSKEDDVRKYVIRREVQPKAEGKKAYTKAPKIQRLVTPRTLQHKRRRQAIKRRRTEASREAEAEYKQLLAKRVKEAKDKKIERRRTSSMQKSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR80</accession>
    <name>A0A367IR80_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004073">
        <property type="protein sequence ID" value="RCH80146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR80"/>
    <dbReference type="OrthoDB" id="10394998at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="119" mass="13356" checksum="A17DF66F6B4AE0E1" modified="2018-11-07" version="1" fragment="single">MPELRNLIIETSYWFGGPSSLVVGIPKTKLNHLKIHISIGSSIMNMFRRSIKEALDKPVLLEILLQKSGQKQFLANTTLLNQVEEAAMATNKEHGYSVAIKCISVDFISISFNKMHVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRL2</accession>
    <name>A0A367IRL2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003981">
        <property type="protein sequence ID" value="RCH80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRL2"/>
    <dbReference type="OrthoDB" id="2288453at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="33439" checksum="32958398414FF4B6" modified="2018-11-07" version="1">MSIFNYVNNSNNNRPMLSRYGSFSGSYTDTATNEALAAELQHTAAQLSATQHHVKQLEDRVNALTAQQQQGPSRIGRDSAMSRDIRTHYEGCVRRNMRWNLNEEFGHPDNQLVFDELLTAVTLARGTQRLPQEEAVRERMAIRQRIHHAFKNKKRYTRVSQSVGGGEASKSKLRSRKARKLKGRREAFVRHRDAFPNEEYPGASTFFEMAYVSDEEDGQINPDTGKVMSFKVLTPSWRSQKLNDFFVELDRLRFQRSNALGHLERVAEPVAVELPQQAVESLPRWGLKQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS20</accession>
    <name>A0A367IS20_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003996">
        <property type="protein sequence ID" value="RCH80291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS20"/>
    <dbReference type="OrthoDB" id="2290844at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="32564" checksum="9A6EE74CAE19B718" modified="2018-11-07" version="1">MSFSLLRRSFHSIRPLYQEAWTKTSLKKLKKNELLQLAKQHHVQKVMGTKNDIIDQLLLLQEKKNNQDDFDKDWVSAFESKVAHRTHRKQVAVDEPKPSSKPHPLNDNIFRTKPVTATSEEEETVDQPVIDEFKHIDEKSNDENNHDSSQDEIDQKWVEAFELKVNSRKSKRREQQAEPIINRSIDIESTLEDDIKEVVQNEQDSKKETTKNDQVKDVVQNVENKANDTVQNVENKAKDAVQNVENKTNNTLVSSMIGTSLLVWYIGGQEGFIKIWEFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITL2</accession>
    <name>A0A367ITL2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003635">
        <property type="protein sequence ID" value="RCH80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITL2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="79" mass="9033" checksum="6E21CAC56D66ABB3" modified="2018-11-07" version="1">MIWKDVELKVAVVIESSQQNEENAESDDEDQNVDRFKREMANLETNPNRIHEARATETFITDGAMVEIPGIIGIYVKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU56</accession>
    <name>A0A367IU56_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein ymc2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_002728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003534">
        <property type="protein sequence ID" value="RCH81208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU56"/>
    <dbReference type="STRING" id="86630.A0A367IU56"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="117"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="225"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH81208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35345" checksum="6796235AA3A3FE4C" modified="2018-11-07" version="1">MSIRELKEKDFEARTTQLRSLQTYRTVIAASSAAVISVLAGFPFDSIKTRMQTHHYNSIMSCVRTTYAEEGARGFFRGMIPPLITVSIIKSASFSIYEGTKKSLIQRGIFNNDTLRSTMGVSTVSGGVSGAFIALLSCPLELVKIQRQLELVLLKRQIAMGQVSSNEVAEASSWKSVKQIVNRRGIFGLWSRVGCHSARDALGTGIYFGGYETMKRQLSGDRNQSGPLIHFLSGGLCGMLSWLLVFPVDVIKTNLQKDIMLDNPKYNNAIECAKHLVKKNGFRGLYRGLNVTLIRAFPIHSLNFLVYEQVLRIIPANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUZ2</accession>
    <name>A0A367IUZ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol-3,5-bisphosphate 5-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FIG4_1</name>
        <name evidence="5" type="ORF">CU097_002936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003402">
        <property type="protein sequence ID" value="RCH81510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUZ2"/>
    <dbReference type="STRING" id="86630.A0A367IUZ2"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="192"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH81510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="368" mass="42273" checksum="9AC028E807F6BFC6" modified="2018-11-07" version="1">MSQDAQILTDNPDCLQDNYVDFNQQQILESATPDLSQEASAKKPTLKWAHPRFILSSFQLYETKTRYYVVGTNQAKQRYRVLQIDRTNPNELTVIEDDVLYTEQEKTKLLKMIEDGNLSVGGLQLSTMEIYGVIGFIRFTQGWYIIFITKRRQVAVLGGHYIYHIDKTRLVPIGPQVKLDKNSDEARYITTFQNIDLAKNFYFSYTYDLTNSLQNNLTQPPLDVSGTKKTQGLQLNDMFVWNHYLLSSGFKNLNSKSGWILPLIYGFVDQAKISVFGRNILVTLIARRSRYFAGARFLKRGVNDKGFVANDVETEQIVTDMATTSFHSTDCLFGNTRYTSYVQHRGSIPLIWSQDTTNMSPKPPIERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV52</accession>
    <name>A0A367IV52_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003406">
        <property type="protein sequence ID" value="RCH81499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV52"/>
    <dbReference type="STRING" id="86630.A0A367IV52"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="236" mass="26986" checksum="1EF01750B2F7E843" modified="2018-11-07" version="1">MTVPISEQATQNLQKTKPASNPSQSPSPVLNQIDLPKELWKVMNFLWNSNMFRIESLFLYHGDLVISTYIRQCLDTGEQFDTNTLLGNQDSDKLSLSELTLKEESVSKRSLDKEAISANSMIDVLVAFLDCLPDPVIPTSMYERALEASESVDAMNMLKESLPPFRRNVLLYIGMFLRQAIDHAPSSVRKERENKIVELFTVLLRPPVDFKERNPLVAKEKREKFILQLLKSLKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWD6</accession>
    <name>A0A367IWD6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003283">
        <property type="protein sequence ID" value="RCH81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWD6"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="21695" checksum="E8964E991C25BEA4" modified="2018-11-07" version="1">MGYCAHNSNSSSSSNRSCSSSTSSRSSNHDNNNNTHSNNNDSTPLLLNKTFKNYSTVTDDTSRREEQVNCIEKYIDLFSTSLYLENTLAVARDHLANERTFLAWVRTSLSTISAGVAVTQLFRLDKENNSGRYLGMAFVIIGILYMIFACLRYFHTQTSMTKGYFPASRSIIFITSTVTLSALIAVFSIIISRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWM3</accession>
    <name>A0A367IWM3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003160">
        <property type="protein sequence ID" value="RCH82077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWM3"/>
    <dbReference type="STRING" id="86630.A0A367IWM3"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="164" mass="18488" checksum="1395C3CED0BC3188" modified="2018-11-07" version="1" fragment="single">MSSEKVVIKEDRSTAVQFSEIQIHHNDQELIDIAKKRLRRASTSGSQAIIAYRTLSITVSENQAKGVTKSKKTQKNLAEDLSNVSYHKLSITELEQQYRTSAHGKNAISPPPNNWFKKVYDYFFGGFCPLLWIASIICWISWRPLGDPNPAPLNLTLAIILMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXG9</accession>
    <name>A0A367IXG9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_005752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003029">
        <property type="protein sequence ID" value="RCH82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXG9"/>
    <dbReference type="STRING" id="86630.A0A367IXG9"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="268" mass="29763" checksum="A1B0D42E39AA4C17" modified="2018-11-07" version="1">MTPSNTFVHNLVIDNMLFNLFDTEDASVASHAAATNTNNTNTKAKNQTSKRSQVKNACVNCQKACKKCDDGRPCQRCIKLGLTDTCVNSPRKERKKGLKRGPYRKRVRKDHKTSPAINKEQVTNQQPPYDCMAMFLNFPITETPPEMAYSNCFSNNNEKNVMLSNAVVVKEQRNKNTILNSTSSPSSSPKSVDSFQDDDNNNNSKVTIPHVHPSNHLSLCDNALFSLPKAEGMSISSSHLGTDAFSCLSPNELIDQWLKSTDGQELFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXN5</accession>
    <name>A0A367IXN5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003092">
        <property type="protein sequence ID" value="RCH82241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXN5"/>
    <dbReference type="OrthoDB" id="2256270at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37018" checksum="17787F10521540B9" modified="2018-11-07" version="1" fragment="single">MSTNSTLADGKSAQDLVREQKEANFTIIFVSVGFSCFIWQMLTTGKMAYKSKKPIVLLVFLQSVLGVVVTFVTLLICIVEVDCTFRLFFSVVGVNIGDMALQFVLLWKAFLGNERSKLILFVGSIPIISIAVFIVINLTIGRSGSFLQESVCLTNYPTYIVITKAAIDFTANVFLSACFILAIYRHYRLFGNSIQRTLLKEGLLYCFGVCFSNIICGILLTLEVIGGNTPVLYTIDWYLASYLVIKQLRHSKKQVSIPKQYYAPNNNISPGVDDDDDHSSAAEASILPPPDEELRHTFNSIEKSDIMERGYIYSTSTNYTVSTVKEGDMSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXS5</accession>
    <name>A0A367IXS5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CDC28_1</name>
        <name evidence="15" type="ORF">CU097_004040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01003014">
        <property type="protein sequence ID" value="RCH82436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXS5"/>
    <dbReference type="STRING" id="86630.A0A367IXS5"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="74"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH82436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="42874" checksum="099292AF781C3522" modified="2018-11-07" version="1">MVENKNVLVQEKGLKDENAAPKKPLLSKPNTRRENQSQQQLEEELKARMIKRRQREKRLREQAAKDDKDGCEKYEKLSKIGEGTYGVVFKAMDKKTKQLVALKKIRLNLMEGVPTTTIREISILKELKHKNVVSLLDLEQKDTLIYIAFEFFDLDLRKYMDNVKREGLSIGHIRSFMHQLLKGLHYCHSHRILHRDLKPQNLLIDKTGRLTIADLGLSRAFGVPMRTYTHQVITLWYRAPEILLGSPHYSTAVDMWSVGCIFAEMLTMQPLFPGDSQIDQLFKIFRALGTPTEEMWPGVTALPDFNNNFPPWKPSNLKERLKKYPNNLPAEDSAYHLLKCLLTYDPASRISAIRAEEHPFFFEDLSLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXX1</accession>
    <name>A0A367IXX1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003056">
        <property type="protein sequence ID" value="RCH82331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXX1"/>
    <dbReference type="OrthoDB" id="2251393at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="124" mass="15059" checksum="5D3A6D9AB8659DC1" modified="2018-11-07" version="1">MAIECNSEIYEEDAALIKEEQEKQRTLRTLSQYAVQLSLIRECLALNNTNEIPLLVWMRALEGNSITNEQRFHRFVQHITTWFSSRYERVIPIKTNHERNFFVDFIVPIFQYFHDQVQYLQFQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZG1</accession>
    <name>A0A367IZG1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEIH-box ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BRR2_2</name>
        <name evidence="9" type="ORF">CU097_000685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002784">
        <property type="protein sequence ID" value="RCH83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367IZG1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="496"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="718"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1335" mass="152801" checksum="3DDFF65D354AAE2A" modified="2018-11-07" version="1" fragment="single">MAENYAKANQYQYASNSSLVLQANRKGLPRRDQEPTGEPDTLWGKIDPKDFGSRAEREAPKGIEEKKKKAAARKSEDVLERRRKRQQENAMRRAYGYASVLAATEDQEGLNYIPRTNETREAYELILAFIYDYLGDQPRSVIRSAADDILQTLKTDTLKDFDKKKEIEQLLSSTIESEKFAQLVNLAKRITDYSADGEPMDIDGSGKVGEIDDELEQEEEAESTDEEDGFKTVLPGQEKKKKGKKSAFSTEPSDTIYAHDIDAFWLQRRIAAYYPDAHTAQEKTVQAFDILGSESIDVRDCENELMGLFDYDKFDLVRILTKNRDLIYWCTRLARVDGEEKEALEKEMQEKGLGWILRSLGGDRQRRGEALERKGVVDTAMEIDEESKASHRSRGQLPTTVTITPGTTAAPKQMLDLESLAFDQGAHLMSNKKVKLPDGSFKRSKKGYEEIHIPAPKPEPVATGEKMVSIKSMPDWTHDAFVGATSLNRVQSRLYPTAFQSDENILLCAPTGAGKTNVAMLTILHEIDKNRDPESGLIDLDAFKIVYISPMKALVAEQVGNFSARLKPYGIKVAELTGDRQLTKQQIAETQIIVTTPEKWDIITRKASDRSYTALVRLIIIDEIHLLHDDRGPVLESIVSRTIRTMEQTQELVRLVGLSATLPNYADVAAFLRVNPNTGLFHFDSSYRPCPLKQQFIGVTEKKAIKRFQTMNEVCYEKVIEQIDQKEENQVLIFTHSRKETAKTAKTLRDMALDKDTISRFLKQDSASREILQSEAATVKDGNLQDLLPYGFAIHHAGMTRADRTLVEELFADGHIKVLVSTATLAWGVNLPAHAVIIKGTQIYSPEKGRWVELSPQDILQMLGRAGRPQYDTYGEGIIITSHNELQYYLSLLNTQLPIESQFIAKLADNLNAEIVLGTIRNRDEAVQWLGYTYLYVRMLRNPSLYSITPDEMDEDPHLEQKRVDLIHSAATILDKCNLIKYDKKSGRFQVTELGRIASHYYVTHHSMSTYNQHLRPMMSEIELFRVFALSDEFKYIPVREEEKMELQKLLERVPVPVKETLDEPTAKINVLLQSYISQLKLEGFALVSDMVYVTQSAGRILRAIFEICLKRGWAQLTKTALNLCKMVEKRMWLPMSPLRQFKTMPQDIIRRLERKEFPWERYFDLNPQELGELLGQPKLGRTLHKYVHQFPKLDLQAHVQPVTRSLLKVELTISPDFQWDEKVHGIAEAFWIMVEDVDGEHILHHEYFILKQRYAEDEHFVSFTVPLYEPLPPNYYITIVADRWLHCETKLPVSFRHLILPEKYPPHTELHDLQPLPVTALRNPDYEKLYAGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZL6</accession>
    <name>A0A367IZL6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_001985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002767">
        <property type="protein sequence ID" value="RCH83122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZL6"/>
    <dbReference type="STRING" id="86630.A0A367IZL6"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="259"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="259"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="526" mass="59302" checksum="67DE91968A507307" modified="2018-11-07" version="1">MQAFQHQYSNNNNNDNNNNCTNFESVREFLNHCHLSQYYDIFISEGFDSISSLLEITEEDMIVMNIKRGHRRLIQREIATAKGIPRDQPLVTNIMGPKYSLDIPSSLKVEHSRGPAANYASSGYETLITGMTSPRSMNSGMGGSNTSGNSSSNNSGPNLTSRFIPPNMAALSDNHNNNNNNNNNGSSNNDNSNAKDSIDTIHGGRSSSRSSSTNKIIPSQPIIRGTSISSNEDSESVQSDSTAPKRKYRRHAKPDRNAPIKPPSAYIMFSNDSRAKLKDQNLSFAELAKVVGEQWKNLSYYEKQAYERKAMRAKDEYLAALERYRETDEYKRYQQYLKEFKAKQESANRLIDRARKRAKQKSPGSGSAADASSNGNSTGNGSSGSSGDNNDKDSMQSMSQTKGLPSHRAYIDQPMTNDYQDVENYRHQQQEQQQHQEQQEQPSSSSLPEQQHPQWNYRSDQMMRGIIPVEFVHTPQPKYSNNNNDNDNPNNLQVLNGSKHPLDTNTPYQERPHKRRSPRLRKPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZT1</accession>
    <name>A0A367IZT1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Palmitoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PFA4_1</name>
        <name evidence="1" type="ORF">CU097_002701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002742">
        <property type="protein sequence ID" value="RCH83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZT1"/>
    <dbReference type="STRING" id="86630.A0A367IZT1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15323" checksum="FE149217B9A8233F" modified="2018-11-07" version="1">MGLVIAIIGVGVLTCYHVYCITTNTTTIEGWEKGRSLTIKGMGRIQHVKAPYDQGIYENIATVLGKYPFFWLLPIPMRGNGLDFPIKVGNSLHATSSTTQLNRPVSVETFWSVNTTTTMTPLKSIAQPQSSFVSNATTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J163</accession>
    <name>A0A367J163_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002590">
        <property type="protein sequence ID" value="RCH83666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J163"/>
    <dbReference type="OrthoDB" id="2281714at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17685" checksum="CE31496F06407AE5" modified="2018-11-07" version="1">MPKIKGKAKANKAPEHKNDRRKKQASFIAEQDDFDLDAAVNELIWQSQRPASETKPHINPTVECPICSQLYSRNRIELHASDCTGGFVDDVPSTSKKKNTIATGVALNEAKRKKTKNTFVENVNYYVESDDLLAVDGVGFNNEVTNSGWETRGQIRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3X6</accession>
    <name>A0A367J3X6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002315">
        <property type="protein sequence ID" value="RCH84623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3X6"/>
    <dbReference type="STRING" id="86630.A0A367J3X6"/>
    <dbReference type="OrthoDB" id="1718410at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF11">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="689" mass="76725" checksum="43CC18B8E2F7E693" modified="2018-11-07" version="1">MAHDDNRMAESSIDLQISEKISNTENDQNTILHPPPSFAESEFYQIKMRQLKKRRGYALKGTNIPSRYPNLSNLWEFAGWGSTYYVEIEPSDIERYERESKRKTAIGQWRATSIAGNDLIASVLYSIGPCAVQSGKYAPISMLLVALLMYPMKRIITEVATAMPLNGGTYNALLNTTSKAAAAVAACLSILDYLATCVVSASTASAYLAAEVELPAKLTPFIITIIILIVFSLICILGLRESSTLTLSIFTLHLITLAAVMVTSVIAWARHGSQTLVDNWYNTPDPPGSNPVLLILKGACIGLLGVTGFESAENYIEDLKPNTFPKVMNNMFGFLFIINAPLTLLTTALVPINVIQANAANVVSILGQYATGGSRWLRMWIMIDAVIVLCAGVLTGLIGAVGLVQRLANDGILPKFFLIRNRMTGSYQYIVLAFLILSITLYAIVGGDTSSLSGVFAVAFLGSLSTFAVANILIKYKRDRLPRPVKVSLGVSVLVFLVLLTGLVGNIIIDPYIAEYFIIYFVVVLTVVLTMLKRCWLWKLCYWLFDQMDLQHKYPHLSERIENYIQNRIKDIRKNPIVFFLNTDEPHVMNKAIQYIKKNEHTGQIKFVYLYEHLDDIPEEIEVNHRMLDEVYPKIQIDLVFIQGKFNPATVDAISRQLDIPKAQMFMACPGPNLTHSFGEFGGMRIIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4X3</accession>
    <name>A0A367J4X3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002222">
        <property type="protein sequence ID" value="RCH84955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4X3"/>
    <dbReference type="STRING" id="86630.A0A367J4X3"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000002">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001859">
        <property type="entry name" value="PRK00591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="383" mass="43486" checksum="6D5C39B7702930DC" modified="2018-11-07" version="1">MFRKSFQFVARYSTKGCCFAPNSKITPTLENKLLRLSQRHDTIISQLNNSNEIDSVELANASKELASLTETKELFDRWQKTIKDLQELGTILSTGDEEMQELAKEEYEEMTDQIKALEKDIIIQLAPKDAADETSAILEIRAGAGGDEASIFSADMARMYERFAQLQRWKWEVLACSEETGSKGFKDITVNVGGKNVFGLLKYESGVHRVQRVPATESQGRIHTSTVTVAIMPQPTEVQVQIRDSDLKIDVYRASGAGGQHVNTTDSAVRITHIPTGLVVSMQDERSQHKNKQKALKVLRAKIYEQERIKTEQSRRESRNKQIGTGDRSEKIRTYNYPQNRVTDHRINLTLYELESIMSGESLLNIIRPLQEHYLIESLTEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5A6</accession>
    <name>A0A367J5A6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat domain phosphoinositide-interacting protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WDR45L_1</name>
        <name evidence="4" type="ORF">CU097_005220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002180">
        <property type="protein sequence ID" value="RCH85113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5A6"/>
    <dbReference type="STRING" id="86630.A0A367J5A6"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="44680" checksum="2D32C0046A74DF8E" modified="2018-11-07" version="1">MNLSKVPHSIHDAPGLLYAGFNQDYGCFAIGLDNGFRVYNCDPLTEHSRNESEEGGVAIVEMLYRTNYLALVGGGKNPRYAPNKVIVYDSKNTKPVIELEYKAEVKNVKLRKDRLTVVLQNKVFVYHFSIPPRLLHTFETCDNDKGLAAISTLPDHAILTIPGKQKGHVQVIDLNTLGYYTSVENEQLPPLLAQQHTNGTNTRTSVNVSIIPAHSGRLSCLSLNQDGTRCATSSDKGTLIRVFDTSTGTLLHELRRGVDRAEIYCIAFNSESTRLCVSSDKGTIHVFNLDPSVVTAADHKPRGPTYGQVPVSPTHSPSHYGLTLSGNRGSALSFMKDILPKYFSSEWSFANAKLATESRCLASFGHQKNTIIAICADGGCYKFSFDPKKGGECNRESFERFLKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5S3</accession>
    <name>A0A367J5S3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Proteinral transcription repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TUP1_2</name>
        <name evidence="13" type="ORF">CU097_003328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002146">
        <property type="protein sequence ID" value="RCH85245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5S3"/>
    <dbReference type="STRING" id="86630.A0A367J5S3"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF728">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR TUP11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH85245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="553" mass="62337" checksum="C9B67739FBDBC334" modified="2018-11-07" version="1">MSVYNHRAMVPTPHSARILELLDSIRAEFDQLTQEAFVCKSQRDEFENKIAHQIKEMTKFQQSLLEMERAQQAIKKQYEEEIARLRQQLELYSNKRSQQPMIKHEQPPPNIGPASNYFGGIMNAAIAPASAAPAPPNSAQMMPTTNTMGPLEDPAYMYNNKSLDKRPTAKEFVPSSSQQQQQQQQQQQQQQQQQQQQQQQITSLADLDPNSVPDNLKIEGLDWFALFNPKVKRILKTNLIYTLEHSSVVCCVKFSLDGRLLAAGCNRVTYIYDVSNGLKICTLQDDTITQEGDLYIRSVCFSPDGRFLATGAEDKQIRIWDISTKRIRNVLLGHDQDIYSLDFSRDGRILASGSGDRTTRIWNMADGKCLHVLAVNDLNQKDPGVTSVAISYDGRLVATGSLDKMVRVWNIQSGQLMEQLEGHRDSVYSVAFMPNENELISGSLDKTIKLWRLGTNMNRGFVHSNSSTARNPCKMTFVGHKDFVLSIACTYDGKWIISGSKDRSIQFWDPKTGQPQFMLQGHKNSVISVAVATNGRPLFASGSGDNRARIWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5X1</accession>
    <name>A0A367J5X1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002148">
        <property type="protein sequence ID" value="RCH85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5X1"/>
    <dbReference type="STRING" id="86630.A0A367J5X1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="252" mass="28778" checksum="7CC520D5D933D705" modified="2018-11-07" version="1" fragment="single">MSNWDSSQLEKQFDNLTVNGDANKWNNVASQRTQNNWQRGAYQQNQSTKGRGGQYSSNNNRGRSRSRGGYEQSYRGRDQRGGYQYQQAPQWKQEQSRSQRNDWQQQNTWGRQRQQENQSGGSRAWGNSSSQSWNTQNNTSQNWNTQNGSSQGWNSNKTSVNPVNTAATSSSNSWNQKLTENTASWNNTEPRQATEEKTSWEEKSTSSSGGWGEMTLESMGWTESNKRPKDVKQPGKGIWKDGVHELGDKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6E2</accession>
    <name>A0A367J6E2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue light receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">WC2_2</name>
        <name evidence="3" type="ORF">CU097_005910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002084">
        <property type="protein sequence ID" value="RCH85493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6E2"/>
    <dbReference type="STRING" id="86630.A0A367J6E2"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS fold-3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="235" mass="26643" checksum="AF6FA6A764982623" modified="2018-11-07" version="1">METVQTDGNNDNSDNQVMKLRMGSSFGEFTRHKNWSQSILDAIRDVVRKPGDIVGHLFTEFIHVDDVDNFVRNFRLAHEKMKIFRICYRFLRKDGKYATLETRGQFYKTSFFGNARCIPTEASQKEFSSEERDLSNAQSLADDESGVDYSNDEVDMPAQSSLVYAQGVSPYHNISDSSSLFTELRYDLGERSMGISMGLCSGNLTNVNESPANVPFVENAEIQEENNEPRSEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6L0</accession>
    <name>A0A367J6L0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002073">
        <property type="protein sequence ID" value="RCH85535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6L0"/>
    <dbReference type="STRING" id="86630.A0A367J6L0"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="528" mass="60387" checksum="C94E793EF3814184" modified="2018-11-07" version="1">MYRIKRYCTENRMIQTIAEHHVLRRSFICFLILAILLTMIVPTWQVYLEEGRSSTLISFNEPNIRGESLYIAASVLNVNFSEKRYTINFSIQPNGTLANEYGQLNQQVTLRFSSLRSYHYDIGETIHPIQVTFSYEDGNQIDYPLDIYSANLEIFAFYKNDTTKSIPITFHLDASITSFHFMSSIKHNPVVEDDGNDVPFVSDKISLQISTGRSTTTLVFSIFICILMWLLSLVMGLFGYQVVFRKRKADAHACMIGITTLFALPAVRSAQPGIPEVGTVSDILGFYWNMAIIACSSIAVTMCWVIRWDNPMDRDNKRNMSIKAFKAHVQATIRLTKVVLELEWTIFTRFIVGVIVATFLSIIYLVWTLRKSRRPLVIWDRLNKPIIKLFRPRIFAFLMRNSNPYSGSIDMTITTFSRGFCTGFMRDRHYNRNTSKSIHATALATFAETVGELGLLSSLSDDKDEVSLSSLELEFKKKARGLITASTDFTMPEITEEKQEVKMDVIVKDRMLDTVAIVHLVWTVNKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6P0</accession>
    <name>A0A367J6P0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002066">
        <property type="protein sequence ID" value="RCH85565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6P0"/>
    <dbReference type="STRING" id="86630.A0A367J6P0"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017034292" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="496" mass="56380" checksum="BBCBD5F3FB92A1C5" modified="2018-11-07" version="1">MKTAPITTLAVSCFFYLASAATHRTKVAILGGGVSGISAALKLTEEGIHDFIMIEARHELGGRAQNAPFGNTHVELGCNWVQGLGTNPINELAKKYKLNTASTNGDDVVFYGEKGKIDGEAKYKKFNGYFEKMTDNVLKRIKRNLADLSGRAALDLAGWTPKTFLDDAIEYYVWDWEMGETPELSSSMFTVLNDNWTYTGFGPGSDGDNMVLDNRGFKYIFQQEAKKAFKAKQSRLMLNSIITKIEYNKEGVVVYTKAGDVVHADYAISTFSVGVMQHKDIEWSPRLPEWKMEGIYAFHMATYTKIFMNFPYKFWDDNEFVVWADPDRRGYFNTWQNLNAKGYLPQNTSTNIFFATVTQDMSYEIERMTDEEVKQAALKVLRRMYGDHVPEPTDILFPRWHSNPLFRGSYSNWPIGELSQHHINMRAPLHNRLFFAGEALSAKYYGFLQGAWFTGIEAAESISQCMKSKCPIAHYFPEITNPVIYPNTIAKRDIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6U9</accession>
    <name>A0A367J6U9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock 70 kDa protein 12A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002049">
        <property type="protein sequence ID" value="RCH85636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6U9"/>
    <dbReference type="STRING" id="86630.A0A367J6U9"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="64223" checksum="2225E2F97B1AA8BA" modified="2018-11-07" version="1">MISQQDNYKVVIAYDFGTTFSGASYAFTHTTVPEVFDIQKWPQKGGNFYPKTPSISAYKKSDPSTIVEWGHSAKKLMSKPQAAKEHFILTNFKLRLDETLFLRGSLDINKRSPVDNIADYLTCLHQHVLDEVTRGFAKNYPPETFRYCLTVPAMWSDLAKFYMRRAAIKAGLIHADDPQDRLILISEPEAAALYCERMCEQVNLKKGDRIMICDAGGGTVDLILFEVMDENIQSNHRLKEVTKGMGESCGSVFLDYNFRTLLEEKLGDQVKDLPPATINNLMDQFIDNIKPEFDGLDDQYLNIPVSIDLSQLDDDCLDEGTMILRAQDLKEKVFEPVVRRVLALIEKQYNQVSDQRVSCIFLVGGFGSSNYLFQRVQETFQDRVKQILCPPRAAMAVVRGAVYFGLNPRLITSRVSRRTYGINAGLPFDESIDPPSSRVVRPDGSIRCTTRFLVFVKKGDVIPVDHCIKERMFVYYGTIKATDILLYATEEDTEPRYYDEPGVKQVAAISVPIPYMPRVAHGERVAYTVRMYFGLTEIRMEADFGTGIVHKVQCNFDAVDKYSDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6W5</accession>
    <name>A0A367J6W5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">MED6</name>
        <name evidence="10" type="ORF">CU097_008894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002039">
        <property type="protein sequence ID" value="RCH85678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6W5"/>
    <dbReference type="STRING" id="86630.A0A367J6W5"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="247" mass="28763" checksum="9A167AAC4EE62927" modified="2018-11-07" version="1">MQRLAATEDLTSVEWRDTNWLERVGGFQNQQVVMDYFALSPFWDRQCNNQVLAMQTQYNDLRQPYEATVQALRKMTGIEFAIVHEQPPVWVIQKRYRRGPAEDDVNPIATYYIMGANVYQSPTIYSVIANRLLTSLFHVNSAFKETQKMMTFHPSKGYNWKQSNADQQKKSPNTVLRAQEALALRHWMDRAIEVSAMKVAQSRQVIEQVEQEDVSKLNADIPAIREDGKRPRKRNDEGNLVNRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J735</accession>
    <name>A0A367J735_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002022">
        <property type="protein sequence ID" value="RCH85753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J735"/>
    <dbReference type="OrthoDB" id="2224699at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="22168" checksum="B1FFF46A40DCDC6A" modified="2018-11-07" version="1" fragment="single">RLKTVENSQIGEAELWSSFFHPLLVKILSDNDRDIRLRWPDMVASEKGQGRPDAIISEVTSGEFGASLGFGEYKTSHNEASTSIASSRCFAFKYMVRFGIAFYMANLNHEGVYTFTQLAKMEFPRSLEELPLFVNMKTISLLLQVSQCFQKHCYSQKQCLDLKTKMVQEVNHNALNSLIHGNYSDVRLCHINFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J776</accession>
    <name>A0A367J776_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ectopic P granules protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EPG5</name>
        <name evidence="5" type="ORF">CU097_009441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002063">
        <property type="protein sequence ID" value="RCH85581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J776"/>
    <dbReference type="OrthoDB" id="75419at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058750">
        <property type="entry name" value="TPR_Epg5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26573">
        <property type="entry name" value="TPR_Epg5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like TPR" evidence="4">
        <location>
            <begin position="93"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="304" mass="36072" checksum="21E71565F252C4F5" modified="2018-11-07" version="1" fragment="single">QLERRDSLQQQLQDGNHENNGSPKLTRFIKNMVYEGTAVPTLLVNNDEWFILKGLSKTPGVDNHHIWFAFEALMTETAIERSYRENIMKEEQKSIKRPMDFFCIYRWLHHILITPAEHPLLPLFLQMFFCLYYQKVDDTTVLGSILFSKKQELLAKLRNYIANIQTFYGQKIPSAPGTAEKFQQTYYAMWIWLGHSELRQPGYDISQLPSHFDVPRLTQCRLRTEDEQPWYDEKLFWMDLVDRDRLLQDFLQHNWEASDKFRTESKNVDYCSSSSLRSKRSRLIINETTIIPLPPVQFKEPNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8T9</accession>
    <name>A0A367J8T9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_004026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001884">
        <property type="protein sequence ID" value="RCH86362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8T9"/>
    <dbReference type="STRING" id="86630.A0A367J8T9"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="317"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="446"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="900"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH86362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1068" mass="122640" checksum="4DD63E188FD86844" modified="2018-11-07" version="1">MSRLPTSGITGKTKLSRQQSVADLRKRKTIEVPPVPIPSKSSNTKARSHSFVEPRMTKPISSPVQQDLYIGQRVAVDSMGIVGTLKFLGEAEFKEGYWAGIQLDILGSGKNDGSVKGVRYFSCPPQTGLFVLASKVTPLDQDSDSVRSLSPPSTKSRTARQIGLTTTQLQHQQQKPMNARPPSLHTPVTSPISSNRQSIRSLPQVQSPTPSHYRGIPSPAVTPTNQSSLQDDYYNDAIFSPPNEEMIADTPIPATVASTSESQEQLDHLFGESIRQAPNEAVMKLHQLQLRVEVLEAENRLLKPDGSQPKTDVDKSEAEHKAMVQDLLEEHEKKQKNWEQKQQELQQAIQRLETKIMELETEQMNLMTERDKTVFEATAVRKEKSILEHKVQELESKIAEAEAATAAAQASERTLLEKTKALQQQMNTTNHYFQPGVDQNDSAERQMKLEMEMEEAHEKMNSLREAARAKDMFLGQLSEQVEHYRNAVEEKEREIRRIKADADRHVREKDRVLEELKELEAKWLAHQDCTSKESFDKLKKDYNALKENYQKETHLVQEYQERVRGLNETIDELKRAGLESIELYESSVEMNRVDREALNASLADERRKVALLEAERAELHNAGREAIQTYEATIAEIKKERESLIQEQNAKREALEATIQSLKQEIEQLMNNAATEDLKDVWEKERKRLTEQVMISTEALEKEKSAHDQLRQEAEAWKEQLKESEKLAKERARLEEQLTRLQADYDEQLAARSKYLDEVRSAVESQKKAEAELRRMTEQKEKLERDLQEKTLAGATTADSEKYQLQVQALESEIENLSTQNTMLQKRMEETDQKDLVQLVESLKIENKRLVEKHSKLEESHKQVETECLKLMEEVEKLHHAEQQQPAVIKLEGLSDDDKVKELSQLLQENQNKIDQLVRNHASELRALKEKEEEKENEHKRQIASLNRDISELESLIESKVFKEADLEEALDKERKTIKKLQMELQDLKEDLAMRSRYTTVEEKKTTRQEFGKKTELYCEICEIPGHDLLSCKAVTVEDDQPERPYCAICEEYGLHSTDKCQSQSEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J959</accession>
    <name>A0A367J959_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001858">
        <property type="protein sequence ID" value="RCH86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J959"/>
    <dbReference type="OrthoDB" id="2290457at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="9096" checksum="0A19C3F67CF9DE0E" modified="2018-11-07" version="1" fragment="single">MYKPSNDSAWSYGTEGFIQAKPDLISDYIKLAKEMKLILHKLVHVGMNSPRTFGILVEGATIEVYAMDIQYNGVYRLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9K7</accession>
    <name>A0A367J9K7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_002893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001835">
        <property type="protein sequence ID" value="RCH86590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9K7"/>
    <dbReference type="STRING" id="86630.A0A367J9K7"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH86590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="485" mass="56075" checksum="F02216912316F5A6" modified="2018-11-07" version="1">MQHCCRWKGCTKLFGDPEQLYSHLTNDHVGRKSTGNLCLTCHWEDCDVSVIKRDHITSHLRVHVPSKPHHCAYCDKSFKRPQDLKKHEKIHDENNDTLKPQTGGMNPSLSPQSSSMSHARLPISPPHSTTYSDDSWMQPVISPRSDLYDMKQEPCTPPQYNSNEFIQQLMFNEGELKTDYDTEMMNNLDMLQALVDNGSICPSSLNINSQEQLNNFNLWLSQLTEQIQSPYSEQQKQQQEQLQQLQQQNQYADVLLQFNEPQDVIYPEQDLYVRSYPSMQSADMATQQVFNQQEQLQYDNQLYNDYPVMDNNYSQYSYTPDLKMNGQRHHYTAVPGMASNLFTPDIRTTYNLRSTKEDVKYKTPTTHAKEEKVAEAFKPTIVTHETKKNVTTMMNVFSSTLSVNDKKVMQTKEETAEPSAKKTSSVSKDVLDLLVSDMSDLSIEKKKESSILYPSLDKIEKHQKLLRQLSEWANTGFKQKDQLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9L7</accession>
    <name>A0A367J9L7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_008902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001833">
        <property type="protein sequence ID" value="RCH86600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9L7"/>
    <dbReference type="STRING" id="86630.A0A367J9L7"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="7">
        <location>
            <begin position="463"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH86600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="552" mass="62926" checksum="D529ED7476CAAC3A" modified="2018-11-07" version="1">MNAQRPLSDTCHFDLSAKIFVPSKKQFDPFEVNEANDDPEMDELSHHYLNSNLLDDEPPMTTTTTTTIPTTTKGGNNLFMWQQDDWKSAQKVEDIWKQDKLSSSVWDSFEPYSRGNEQEFDPTLHFYHGALYDASTIEDMNLLKDNCPSAEETQVENVGEDMTTLQMLQTIFSDLSEQKLIDTLEKNDYDVDRTIEALLSNTTNVKPSNNDTKKRQVCRHFLAGECYRKDCWFVHDLQEKVCKFWLQGGCLKGELCEFSHNIDIQEAVANKINSSKQSQVKNDRTNVLNPNDYPALGTSAKQTSVKSQSTNVVAEEEFPSLAAANKIKKSAPPQSVTKTINFAEIAKKKANTPAGTVKRKQATPHPYQKLSLQKLKQPVRIPWLETGSSLNSIYMKEREKAIEYGTLRNRLFAKATEYYLKGDGARARLYSMEAKHYNKLMQEMHTEASRRIFEQRSKHEAFIDLHGLHQDEAIDIIEEQLQTMRQNNYTGIVYIVTGTGHHSGASGLSKKMSKLKPYVEEYLRQENYRFAETNMVGDTKGGVFAVDLSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9T2</accession>
    <name>A0A367J9T2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001814">
        <property type="protein sequence ID" value="RCH86687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9T2"/>
    <dbReference type="STRING" id="86630.A0A367J9T2"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="54" mass="5962" checksum="D460EE990E64A6A0" modified="2018-11-07" version="1" fragment="single">MLGQTVLAILFTENAMMNALLATTYISVIPNLLLYFVPPNIQPTTLNTLVHFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9U9</accession>
    <name>A0A367J9U9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_007944</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001810">
        <property type="protein sequence ID" value="RCH86707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9U9"/>
    <dbReference type="STRING" id="86630.A0A367J9U9"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="14">
        <location>
            <begin position="98"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH86707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="467" mass="52703" checksum="545B49964F2CFDAA" modified="2018-11-07" version="1">MSFITQFTEATHQFLDRHSDIVKLSLTAIAASALTASSILTYQASQRRQRARTLKEELKEAELKKPIDLTPVGTALAHHIPPTFTENTIADQLSGVTEFFGKEGARKVRESFVIVVGAGGVGSWAALMLLRSGVKRIRIIDFDQVTLSSLNRHAVATLEDVGTPKVRCIKKHFKEIAPFVQVEDHVDLLNADNVDELLGGSPDFVVDAIDNINTKIDLMKYCYDRKLNVISSMGAGAKADPSRIQIADISETFEDPLARAVRRKLKKLNILSGIKVAYSTEKPHHVKLLPLEEEKVEDREEFAALPDFRARILPVLGTIPSMFGMAIASYITLSIAEYPHFEPLAIKLREGLYARVHKEMITREYKTFKEKVSTLDVRDVGYIFEEMWHGKSAISGPNDKLCLTRWDKTKPIGYTNAVCMTRIEANEHDSLPENTDLEKHYGKEICDRVKERFRQVEIQKRIWETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA79</accession>
    <name>A0A367JA79_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001781">
        <property type="protein sequence ID" value="RCH86853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA79"/>
    <dbReference type="STRING" id="86630.A0A367JA79"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="77" mass="7808" checksum="22A0FBA54472C582" modified="2018-11-07" version="1">MIWMRASVEASVEASVEASVETSVEASVEASVEASVEASVETSVEASVEASVEASVEASVEASVQASVEASVQANME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAI0</accession>
    <name>A0A367JAI0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001803">
        <property type="protein sequence ID" value="RCH86741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAI0"/>
    <dbReference type="OrthoDB" id="10460754at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20851" checksum="49D5BE10F158B10B" modified="2018-11-07" version="1">MSTFVPQLKRENAFLGDPLKDNFCAICNHDEGADSWCNVTCHCSRKIKYAHRDCLMSMSTCIRCNSSFVKIPERSSFKKPTPTMRQRYLKYTLILFALLYLMLLAYDLMNCTSIQTIYAHELPETDIVDRPDYIKFPKIHMKCLRRGISYSIYYHLFNYYLFVFICLFIIYYMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAM6</accession>
    <name>A0A367JAM6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001751">
        <property type="protein sequence ID" value="RCH87002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAM6"/>
    <dbReference type="STRING" id="86630.A0A367JAM6"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF58">
        <property type="entry name" value="METHYLESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016833977" description="pectinesterase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="35825" checksum="463E39371B42D128" modified="2018-11-07" version="1">MHLSLGYLALVLLCVQLVFAGTVNVCSSCTFKSISKAIASLPNNAESYTVLIAPGTYTEQFTVARSNLVLKSTSGSVTIQFASGHDTSSKTGSTADSAVLTITGKNVMLQDIIIANTFKQGRVANVALHLNAPQAYFKNVKIYGFQDTLLINRDGAGYFDNCYIEGSVDFIWGFGTGYFSNTVIASNQRGTSVTAHGRDTPNGPGGFYFNQCTFKATVPSGPLLKTYDPSISFSSPSQFENTCFFARPWGKYSRVIIMNSNIGSHIKPAGWSAWSNASPNTANVAYGEYKNFGARPWTSARASFAKNLTSEQASQYSAAKVFGGNTSWFQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBS6</accession>
    <name>A0A367JBS6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MXR1_3</name>
        <name evidence="8" type="ORF">CU097_009150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001663">
        <property type="protein sequence ID" value="RCH87412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBS6"/>
    <dbReference type="STRING" id="86630.A0A367JBS6"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="19495" checksum="4C3FE1F9065B21F5" modified="2018-11-07" version="1">MSLTEKATFAAGCFWGVEHIFNKYHKKDGIATRVGYIGGELDNPTYQQVKTGTTNHAEACEVTFDPTKISYETLVEFFYKLHDPTTENYQGPDIGTQYRSAIFYHNEEQKEIAERVTKEVQEKHYPNARIVTKIEPATKFYDAEEYHQFYLEKNPEGYACPTHYLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCR8</accession>
    <name>A0A367JCR8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PRP22_1</name>
        <name evidence="13" type="ORF">CU097_007081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001599">
        <property type="protein sequence ID" value="RCH87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCR8"/>
    <dbReference type="STRING" id="86630.A0A367JCR8"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="394"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="575"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118758" checksum="5320F1239C26571B" modified="2018-11-07" version="1">MEELEQLEHLSLVQKVVSELYNHTGLHEKVLAEFIIHLHDQSNGSLSTFKQSLKDADADFPESFIENLDRIIKTMKPKNKRVNMTEASADEKAKTFPGLAVQDDPEWQKKRKEDIEVADDMMAQLEGINSTSKRRHERSPSPNDRYQRKHHRSSRRSSPGRRYRSRSRSPSRRDSRRRSREAERTRNPDRPSSLQAPSHARGGIMVEDVPSRSIKRMSSPERWELKQLIASGVVDPADYPELNEDLDFNGSIEPEEEIDVEVREEEPPFLKGQTKRSLDLSPVKVVKIPDGTLNRSALAGASLAKERRELRQQQQQQEADAVPQDVTTPWLDPMAGPAGRQFAQDAKGTGRPERISEWKKATFNSATSFGRVTNLSIQEQRESLPVFKLRTDLINAVRENQMLVVVGDTGSGKTTQMTQYLAEEGFANNGRIGCTQPRRVAAMSVAKRVAEEVGCRVGQEVGYTIRFEDCTSPETRIKYMTDGMLLRECLIDPMMSQYSVIILDEAHERTISTDVLFGLLKRAAKKRPDLKLIITSATLDADKFATYFNNCPIFTIPGRTYPVEVLYTKDPESDYLDAALITVMQIHLSEPPGDILLFLTGQEEIDTAAEILYERMKALGNDVPELIILPVYSALPSEMQSRIFDPAPPGSRKVVIATNIAETSITIDGIYYVIDPGFVKQNKWDAKLGMDSLVVVPISQAAARQRAGRAGRTGPGKCYRLYTEAAYRNEMLPNTIPEIQLLNLSMTVLTLKAMGINDLLHFDFMDPPPENNLIQALEQLYALQALDDEGLLTRLGRKMAEFPLEPQLSKMLIQSVDLGCSEEILTIVAMLTAQNVFYRPKEKQAQADQKKAKFHQPEGDHLTLLTVYNGWKNSKFSTPWCYENYIQQRSMKRAQDVRKQLLGIMDRYRHDIVSCGRNYTKVCKALVSGYFRNAAKKDPQEGYKTLLEGTPVYIHPSSALFNKGPEWVIYHEIVFTSKEYMREVTAIDPKWLTEAAPTFFKIADANKISKRKKQEKIEPLYNRYEKPNEWRLSRARRGGRISQTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEN2</accession>
    <name>A0A367JEN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GCN3</name>
        <name evidence="10" type="ORF">CU097_009936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001470">
        <property type="protein sequence ID" value="RCH88422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEN2"/>
    <dbReference type="STRING" id="86630.A0A367JEN2"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="329" mass="35888" checksum="E21187932239E1F2" modified="2018-11-07" version="1">MSYDVVSAFHTSLNDTDLSTPVAVFKSLTDFVQCSTAPTMSEFMQTLERAAQSLRESAQKIDRPQTQHKAYIAVLAGVDLFMRFVNRSSHDFSLSKEAGSFEDFKETLLSRASLILEKASSARERVASIGAQFVHDDAVILVQGYSRVIMNLLYHAANLQNKRFKVYVTEGRPESDGIQAAAALKKAGIPCRAVLDSAVGYIMDKVDMVFVGAEGVVENGGIVNKIGTFQIALVAKALGKPVYAVAESYKFVRVYPLSQYDLPSETPEIVTFTSRRKSFTASSDAVQELATSNPSVDYTPPQYLTLLLTDLGVLTPSGVSDELIKLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF74</accession>
    <name>A0A367JF74_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_010361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001443">
        <property type="protein sequence ID" value="RCH88574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF74"/>
    <dbReference type="STRING" id="86630.A0A367JF74"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="445" mass="50440" checksum="3703F990A37791E9" modified="2018-11-07" version="1">MVNPTHVQHYQYNPTTPEVFMQRANRSRVITLNRPTQLNSVTTSLLIRLLGYLKTCETSKEVDLVILKGAGRAFCTGGDLKHCSEAFVDAPDPHTAKANLQSFSQIYTLLHLVATMDTPIVTLMDGMTCGAGSGIGAFSQFRIATENTCVAMPEATIGTFCDMGSSYYMSRLDANLGTYLALTGRVLKGEDVYLAGFATHFVPSSSLKALEERLTQITEPTLDLINDVIEEYAVGPNHKPSSYTMHGQRLEKISEWFRYNTVEEIVDALRRDGSKFALDTMNTILSHSPTCLKITLESYRRGRTMSLLECLEMEYRIWHISPYLPDFKNGIKAKLVTKQKMEWTPSRLEDVDLEEDIRSRIFHCFAPIIFVPSSRKDYFKRPVNYTLPTEREILDALLTYELNSIEKVIEWCQATCKGKKYGVVEKVTDVLNRNRSRFNKLMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGB5</accession>
    <name>A0A367JGB5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PTP4A1_6</name>
        <name evidence="12" type="ORF">CU097_008872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001383">
        <property type="protein sequence ID" value="RCH88915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGB5"/>
    <dbReference type="STRING" id="86630.A0A367JGB5"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="185" mass="20923" checksum="38902B99366C81B6" modified="2018-11-07" version="1">MYTRAHSPFNTTANRPLINPPTFIEHNGLRFLIVDAPSANNLPLYLKEFKRWNVTDVVRCCEATYPKEPLSEIGIQVHDFVFMDGEPPPAGIVDAWLHLIDDRFLNAEQKQDDKEELSPCIAIHCVAGLGRAPVLVAIALIEDGMPPLDAVVYIRERRRGAINKKQLRYIETYKPRSKGSKCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGQ8</accession>
    <name>A0A367JGQ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TIF51_2</name>
        <name evidence="10" type="ORF">CU097_007444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001342">
        <property type="protein sequence ID" value="RCH89138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGQ8"/>
    <dbReference type="STRING" id="86630.A0A367JGQ8"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="17484" checksum="4D8490EB891059E9" modified="2018-11-07" version="1">MSDKHDDHTFESADAGASKTYPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVGIDIFTGKKYEDISPSTHNMDVPNVVRNEYQLINIDDGYLSLMTQDGATKDDVKLPEGELGEQIERDFDEGKDLIVTVVSSMGEEHALAVKEAPKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGZ9</accession>
    <name>A0A367JGZ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_000314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001328">
        <property type="protein sequence ID" value="RCH89213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGZ9"/>
    <dbReference type="STRING" id="86630.A0A367JGZ9"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH89213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="16677" checksum="1FAF3C12C9934534" modified="2018-11-07" version="1" fragment="single">MPASVNINTPTKTIDISKRGETPTEGDDVIDYHHSITSRSSSSTRSSTSPTQSSSKDSNDKDNGNKVQTTAIPALTPEWYTTVYGSESGITPQMAALGAILIAFGVFLCVMGFRMFKPMLFIMGLLTFGSMTWIALANCRPSNGYINDHITMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI33</accession>
    <name>A0A367JI33_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_011638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001270">
        <property type="protein sequence ID" value="RCH89546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI33"/>
    <dbReference type="STRING" id="86630.A0A367JI33"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="485" mass="54573" checksum="E37E54B4A4A7842C" modified="2018-11-07" version="1" fragment="single">MCGFSAYFHFDSTEPFKALDLETSLQYIQHRGPDSNGIFVSDCGRCGLGHARLSIIDLAGGQQPLSNVSKDIHAIVNGELYDFERIRAELEQKGYSFKTKSDSEIVLPLYEEYGLSFLEHLRGEFAVCIFDSRRNRLIIARDRFGIKPLFYTIQNGTLLVASEMKAFIPMGLKAEWNVDCIMNGGELLGNKTCLKGVYKLPPAHYLVAQPNGFVEIRSYWDADYPEKDVKDTRSVEEMIQGVRERLLESIRLRLRADVPVGVYLSGGIDSSCVAGMATALLREKNPQAKIKAFTISFKDSKDHDESAIADRTAQFIDADFEKLELTESDLLENFEESVWHIEAPQINLNGVGKFMLSKLVRDRGYKVVLTGEGSDEHFAGYAFFLRDYLREPDNAGPEEFRVTDDERAGLSKSLLETLGKTATSTKQPKIDDYEELVKTNKAVNGITGYVFLSKVFSLTPKNFKPEVFQKYGQPNPAFTMVETIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI92</accession>
    <name>A0A367JI92_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase chain 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NADH dehydrogenase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">NADH dehydrogenase subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ND2</name>
        <name evidence="15" type="ORF">CU097_006352</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001249">
        <property type="protein sequence ID" value="RCH89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI92"/>
    <dbReference type="STRING" id="86630.A0A367JI92"/>
    <dbReference type="OrthoDB" id="2251490at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="685" mass="75310" checksum="73A857390B68FA7C" modified="2018-11-07" version="1">MGAVFSIFAGFYYWAPKIFGKMYNERLAQIHFWTLFIGVNTTFMPQHFLGLAGMPRRIPDYPDAYEGWNYISSIGSMISVVATVLFLYVIYDMLVSQPVASMNPWGTPGYFMSTPSYLTESSYILLYTAALSYNALDLQGIGEGVSIYSGLFQVTSVSQSVDTFIFIIGAMILLPWAPITNNLQSRSTVFTAVPTITTYPIIILFTTCGASFLISSADLVSVYLSIELQSFAVYILATLYRDSDSATAAGLKYFLLGGLSSALILLGSALIYGYTGLTNLENIYTLLSVSETNEMNLCAIGLFIFVIGFLFKISAAPFHNWAPDVYDGVPTIVTTWLTIMPKLSILILLLEVQAGVAQSFNVWTNLLLVSSLLSLVIGTVVGLAQTRIKRLLAYSTISHVGFLLLALGVNTEESIESFLFYLVQYSVTNLNAFMIILAFGYVMHSSVSRSSGQNIDVQLIIELAGQFRSNPILGLSLTVCLFSMAGVPPLMGFFAKQTVLYSATHSGYYFLSIVAILVSVIVRVIHFDAPSSEILTVSSPVQKLSSVHSFAIATLTMIIALFAHNSTSSNTIWILMSANILLAPSRPYSEKVSVYECGFDGLLGQTRAPFSIQYYLVGILFMLFDIEILLFYPIAVTLSDLTLMGYWVAMLFSFVLTIGFIVEISAGVLYFTDQRSSIKSYKSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJE0</accession>
    <name>A0A367JJE0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001183">
        <property type="protein sequence ID" value="RCH90062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJE0"/>
    <dbReference type="STRING" id="86630.A0A367JJE0"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="42973" checksum="B93B6BECB7F8DAD1" modified="2018-11-07" version="1">METAVRKATRLEYRPPKQKHLITLRNITLESPSSTEKILKLLEKRLREGYWIITFKVLIILHYLIREGNTQRVAEAICMRRPQTFDISKIKNKKLVPGTIQNIYLYKTYLDRRVTAVSESQIDYTKSGTFRRLTLSEGLFEETIKLQQLLACALSCKFCLNEGDPAISLFAYRLIIEDIFNIFQAVNESIINILEHYFEMTKSDALTSIELYKTFSAETQSVTEFFNAARPYEGALEMKLPPLNHAPTTLIDALKDYVEELDKPSPETTDQGTTGVNPKPFPPRLNLPADNNPFAALVLPPTNNELPVPYMPIASPTYFPQPSSPGSSLQRRITNPFSPVYMQPTGQSQQLPYDTNPFRAMYFQDPRQDPFSSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJR1</accession>
    <name>A0A367JJR1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001164">
        <property type="protein sequence ID" value="RCH90180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJR1"/>
    <dbReference type="STRING" id="86630.A0A367JJR1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF28">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="7">
        <location>
            <begin position="358"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="654" mass="76098" checksum="55A2D5457080A6D2" modified="2018-11-07" version="1">MRKSMTHLKDVSRLISTPEHNNGTCRRRNSHLQTLLQAFQPRPNELFTLPKFCTSCRRRSALIRMYRTLSTPIDTVEPRKPLQPLMRFPKSLSIFNLTDRITLSDLDLTIRTRQADKAWSLFITLSRRGDIIPLTMCCSLYALLTFAKSMVSRGPIIDLRQRQMDQLLDYVQKHHHHTPELFLPSVEPIPIPIRKQIAKYIQLEETEKAWALFFKTVQEGKERLSRNLCIKLIMLMLKDKSLYKNQRKFRINLIASHASCKNEPEDRHLLPSDMLRIANICYRYYRYRYSAAHRLIDEFVENIPKIKQKNRADALEELIWRILSNHDLSKAQEVLDVVREKYADKVDISEMVYVNLMNAYGQQKKFHQALKLFEQFLESNRQPSVKGFNAILHVFASQGEASRASYVYSAMLKLNVEPDSATYTEMIRAHAHTTDHSKCTFFYNKMLQRHLTPNVYTYSALMHASTKRHDIHGVLRWFQIMLYNGVEPNEVSLSLVLKSLSQQPNQNIPDAMHWITREATMVGIKPDATLYTILLKMHAKRLGLESALKIHKEMIANSIEPNTYTYTTLIDACADNDMPETAQQIFELMKNSERHKPNTATYTALITAWARSSKLQQANAIILDFLKACKSDKSGQLWIDEKIKERLSWCAFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLH2</accession>
    <name>A0A367JLH2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LCB2_3</name>
        <name evidence="22" type="ORF">CU097_009357</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001068">
        <property type="protein sequence ID" value="RCH90783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLH2"/>
    <dbReference type="STRING" id="86630.A0A367JLH2"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="21">
        <location>
            <begin position="171"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCH90783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="547" mass="60995" checksum="E837AB119436D373" modified="2018-11-07" version="1">MGKGKRAHTISIPSINLKPPKSSSDHSYAPSFVNTTLSEATSVITKTERWQPPRKPKMKYDDLEHKMEAAPLYVLVCTYLNYFVLILFGHLRDILGKLFKPEDYSHLRMNQGYAPLVSDFDSFYTRRLYIRIRDCFNRPITGVASRTVKLLDRVSSDFNRSFRLTGTVTEALNFSSYNYLGFSDNTGPCADAVEHATKEHGITAVSPRSEVGTTQHVQELERMVARFVGKEDAMCVSMGFATNSTTIPALVGKGCLVISDELNHSSIIFGVRLSGASVRVFKHNNMDDLRELLRECISQGQPRTHRPWRKILVIVEGLYSMEGTIVNLPEVVALKKEFKFYLYVDEAHSIGALGENGGGVCDFYGIDPAEVDILMGTFTKSFGAAGGYIAGDKAIIDYLRLRNHAYNYAEPMSVPVTQQVITSMKIICGEDGTDIGRKKIKQLAENSLYFIERLREMGFIVYGDQGSPVIPLLLFNPAKIPAFSRELLKRGIAVVVVGYPATPIITSRARFCISSAHTREDLDKALEVISEVGDTLLLKVSNEPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMN6</accession>
    <name>A0A367JMN6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001005">
        <property type="protein sequence ID" value="RCH91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMN6"/>
    <dbReference type="STRING" id="86630.A0A367JMN6"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="621" mass="70220" checksum="31AEC5722B7B5924" modified="2018-11-07" version="1">MPTSDKKWKYSSTEDIPLAETVTNRNDGSVLDRSSYPYEDRDENKRSFSVLLKSLFLVFVSIFFATAILLVLLNADGKPLDYTLVKMKITSLTSLLLNLYAIFTGSGIAMAISEYKWIKLRNGAPLTVADIYDGCTRGMGGFLTAIKGAFIDIVLIFALIFNLGLLVLSPVSQELIVPVSLKRNLTSIVDSHLYYNDPFYVNDRTNLSSLPIPPTLNGLTYDNYLIPMSFANVAKHAPFNGAYTCPSYADYCVFRNKSFVSTSLDCTPVTDQEPIVNQSNYKELTTPARYYTEIEQNRTLVNVPTFFYAGEMLNRTFHDLQNYKPPQAPGGFVASGFLYSDYDPQYRSYVGNQTFVLAYSKTSCCVALTKISDISYARCTFRSSLNTTDWMTSNGTLIKHGQETSVPITFDFDHVLGNNTALFKVTKDADNSTRSTGVMVNAYLMQQALLKEFISPQYRPFIQYLRVWNMAYPATVTMFDYLKPAMQMFDLNYAIAPYVEGRYYTQITTEGLIFVTDPPVYSTNKTYCYILFALMFLPVVWWMIVWSIGIKHSNGRGNSQISLMTMEMTPLASQSLRNISNMSSSEAFKRAKSIRVRIGNHETEDKKRLVLKLEDEHGISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN12</accession>
    <name>A0A367JN12_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate decarboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PDC1_2</name>
        <name evidence="10" type="ORF">CU097_012752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000997">
        <property type="protein sequence ID" value="RCH91259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN12"/>
    <dbReference type="STRING" id="86630.A0A367JN12"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="9">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="8">
        <location>
            <begin position="203"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="347" mass="37834" checksum="F2F742359CB9D5F1" modified="2018-11-07" version="1" fragment="single">MPSIKIGQHLLNRLKEINIDVVFGVPGDFNMPLLDLIEDDPELTWGNNANELNASYAADGYARIRGAGALVTTFGVGELSAVNGVAGSYAEMLPVIHIVGTPSTKSQAAGAMLHHSLGDGNFDVFFNMSSMIACASAHLKKQTAISEIDRVISQALLSKRTGYIGIPIDLIFYEVEIPDALPPLQTQLPKNPPQVQEIALRVVSDAISKAKFPVIIVDGCVLRHRCQKQVQEFIERSGFPTYVAPMGKGAVDERLQCFRGCYSGNVTLEAVGEEIKQADLIIEIGSIKSDFNTGNFSYALDRSKTITLHSFATIVFCAEYQKVSMMEFIPLLTQTLPEQPRVFDLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN77</accession>
    <name>A0A367JN77_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001012">
        <property type="protein sequence ID" value="RCH91151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN77"/>
    <dbReference type="STRING" id="86630.A0A367JN77"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="97"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="292"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="377" mass="41996" checksum="9FBC4EDA7631E6AA" modified="2018-11-07" version="1">MSFVETVELKHRRSHLSLDNTIESTVLKDDPLCLEKQKMTDDYISKTLKGQKKLQKFYKNQNELIDSMLTALDKNTQEEEEEETKQLLKLKIAIYGSVVANVLLFTLQLVAAVSSGSLSIFSTMADAFMDLLSSTVLLWASRQANKTNLTKYPAGKSRMESVGIIIFSCLMSCVALFLIIESAQKLVENDHSPDLTYLAIGFVSSALAVKLLLFIYCQSLSKFNSAKVLAQDHRNDLLVNSLGLTTGIVGSRIAPWVDPVGSIIIALIILYSWTSTLIEHIPMVVGKSADTQFLNTITYIALTHPGVTMVDTCRAYYAGNNLFVEVDIVLPPTMELRESHDIGEALQTKLESLPDIERAFVHVDYETSHKPEHQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNC3</accession>
    <name>A0A367JNC3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_001469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000971">
        <property type="protein sequence ID" value="RCH91426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNC3"/>
    <dbReference type="STRING" id="86630.A0A367JNC3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="254"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH91426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="658" mass="72899" checksum="52EE7959B9E130C0" modified="2018-11-07" version="1" fragment="single">GPPIQRDSASPTARPLNFFVHIHPRTNMPKPCGTNESGETIPIQKTIEPVMDMSRPISANIRPLPPITFLYGTQTATSQDYADQLAKQAANFGFSDITVSTMDKWKVLKEGKYKGSKDKHGDEELLVICTATYNGLPPDSAEQFDLFLNTASERNNKTILEGLLYTVFGCGNKQWRTYQQFPIKIDKALEELGAERFFPAGQGDADKDIDFDFQDCIKPNPESNIVPFTSMQGQSDIHVEIKYVEDAPEIQSRPVSANATILARRELQSPDSGRSTCHIEIDVSKLPPVDSEALYRPGDHLEILPANSPSLVSRIAESFDFNLDAVFEVVPESLKGVSPRSLAAEIRGRSSVRDALTYYADLLSPPSRSLLSVFEQELRQVDPDSASRFYKLAILGDDNRDQYGQFITTCRTIADLSDQFPQVKRLDFASFLGTVHVMQPRRYSISSSSSVHGHNATITVGVVDDVVNDKHYPGLASSYLSQAPIGSPISASFRSSSGIFSLPDDPRIPLILVAAGTGIAPFMGFLQERSLQPNAAPSTLFFGCRHPEHDHIYKKELDEFLHKNVLSDVHVVFSRLNSESSVKYVQHEILQHDAALWELLQNGPSKLGAHVYVCGAGAMSKEVRKAFGAIAVKFGEKDADGFINRLIEEKRYREDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNP1</accession>
    <name>A0A367JNP1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000952">
        <property type="protein sequence ID" value="RCH91562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNP1"/>
    <dbReference type="OrthoDB" id="2219748at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="31145" checksum="52B614840F1643E8" modified="2018-11-07" version="1">MPGFRGIRMVSFDKDQQKVVVRSPQAVETAACVVWPEPAISILVDIMAIFYRHITNEPNQREEYYQKAFAALAFHLMQLEKEKVIPPDFLGNMTKEKMQMKWQEIEHEYSNIASSLTPGGPTGQQIWPYFDKVTFIFQTSRIVPPETTRRSVSEGALEEPNTTNPQNSGAGHIPPTSASIPSSPAHVTACSPENGTISRSTATPETDQVQLSPHQESPKELSEQEFRKEMLCLMRRRVELLEEQKAREDKKHKERREIMDRLVNVLEKLAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPK7</accession>
    <name>A0A367JPK7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MLH3_3</name>
        <name evidence="4" type="ORF">CU097_010110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000905">
        <property type="protein sequence ID" value="RCH91900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPK7"/>
    <dbReference type="STRING" id="86630.A0A367JPK7"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="500"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="737" mass="83788" checksum="7D19B49364824DC9" modified="2018-11-07" version="1">MSIERYPIEPIDSSVVYKLRSSVVISTLTDCVKELVQNAIDAEASSIHVSVDTVKFSIQVSDNGIGIENMSQLGRRYVSSKCHSLKDLSQLKTFGFRGEALASIMNESIVKIISRYRSSTDTFEAVWRESKLMGEISKHTKMAQSGTIVIVKDLFYKYPVRRRQASTPYQYVVMMESVKRLLTMYALCFPCIQFTLIDGTRDTKVLYLKKTSSSIDTFRQIAGPEIIKYIEPLEMHEDNINIHGFFSTHGYLNKVSLYPFTIINNYCIPTTNDLYKVVSNLFPSSFKNVLTESNHTTKLKDRRNMAKHPIFFIKLECDKWNSYDISIHLDIFDEFSEFHYIKTLLQRFTRQFLTLSGLTIEKDETVSKKQKATHSVTESTISGDSSKSPYVRHSSSSSTILQPTNPTVTWTDPETGTVYYIDPRTGHSFLTPPATSNYPFSHASTIDRSSLKRQNSNHNNSGQWSGSHISSMTPLDSSQFGTFLSIPNRLSREDLKSAKVLGQVDRKFIAIKLDDKSILMMDQHAADERIKLESMMKSDIISRKTVVLEPCIPFDLNSAAEYELMTSDRILEYLKIWGIHLVTTAAKSIASSVSDDTVILSSSHYFSSTPNTKGYYRVYVTRLPELIADRCITNHALIKNIIRDYVYWIVEQHYNPAIVKTNCPKGMVDILKSKACRSAIMFNDPLSLEQCQDIVDNLSKSSFPFQCAHGRPSVIPLSLSLKPTVIQRTIHWDKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQH5</accession>
    <name>A0A367JQH5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MSS4_2</name>
        <name evidence="14" type="ORF">CU097_006759</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000869">
        <property type="protein sequence ID" value="RCH92156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQH5"/>
    <dbReference type="STRING" id="86630.A0A367JQH5"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="85"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH92156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="485" mass="56198" checksum="AF4478BE2532C4B9" modified="2018-11-07" version="1">MQVATTTEIYSPETSPTKRKDSGFVIDKQSEITSDNTRPSICILPQNNSKLKSPQSPKGHTKRKTYADDSEDEFRVTIGTKVAEGHPNYQLMYDMLTGIRIAVGRVSAKMQRNLTQDDFYAAHKLAFDATGNELTPGVKYDFKFKDYAPWVFRHLREKFHIDAADYLMSLTNKYILSEIVSPGKSGSFFYYSRDYRFIIKTIHHSEHKFMRKILKQYYEHVCSNPNTLLCRFYGLHRIKLPRGRKIHFVIMGNVLPPNKDIHATFDLKGSTFGRLTSEEEIKKNPRAVLKDQNWVKRNEKMELGERKRVLFLTQLERDVDTLRRLNIMDYSLLVGIHDIKKGNTECIRNQSLHIVTPKADEREKRVTKRTRSDVMRRVRRNTNTVSLESAELPSSPSEDRKWCIFYADDGGFRSSDEQDKPLDKLYYVGIIDILTPYNIAKKAEHIWKSITQDKTGISAVPPVIYGKRFLNFMIQAVGSSLKKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQT8</accession>
    <name>A0A367JQT8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FAL1</name>
        <name evidence="16" type="ORF">CU097_012435</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000847">
        <property type="protein sequence ID" value="RCH92307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQT8"/>
    <dbReference type="STRING" id="86630.A0A367JQT8"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH92307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="396" mass="45094" checksum="F349EF065667B41C" modified="2018-11-07" version="1">MSFDHTTDNKLDFETSETVQVVPTFDSIGLKEDLLRGIYAYNFEKPSAIQQRAILPIIKGRDVIAQAQSGTGKTATFSISALQTIDTTVRETQALILSPTRELAMQIQTVVLALGDYMNVQCHACIGGTSIGDDIRKLEAGVHIVSGTPGRVYDMIRRRVLRTRNIKMLILDEADELLNMGFKDQIYDIYRYLPPGTQVVLLSATLPNDVLEMTNNFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKKKVDWLTEKMREANFTVSAMHGEMPQKERNAIMDEFRQGASRVLITTDVWARGIDVQQVSLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFVKNDDLKILRDIEQYYSTQIDEMPMNVTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQX6</accession>
    <name>A0A367JQX6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000878">
        <property type="protein sequence ID" value="RCH92091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQX6"/>
    <dbReference type="STRING" id="86630.A0A367JQX6"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22002" checksum="6AD58F5BCEB86C09" modified="2018-11-07" version="1">MGAIEFIETMDASSLSISKEEFDANIEKTMNELEQKQPKEAMSDKQKISYEDALHPWHAKRIQKEQPSMDFGSGIAQRSMSFVEKLFSDDNEGESSSKRSRQRSQDSHEEPAPLAQQLPVPANLLNEQQRILPARRVQEEEDARKQFDEHLSTIVSMFPNIEPGVCFMILQATEGKLPETIERYKIIDIHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS32</accession>
    <name>A0A367JS32_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Programmed cell death protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000789">
        <property type="protein sequence ID" value="RCH92716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS32"/>
    <dbReference type="STRING" id="86630.A0A367JS32"/>
    <dbReference type="OrthoDB" id="2289628at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052831">
        <property type="entry name" value="Apoptosis_promoter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48190">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48190:SF2">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="34098" checksum="46B246B2D44E4526" modified="2018-11-07" version="1">MSITRTKARLGEAISLYEQLSQEIKDTNNAAIMTDEQWASYIRTLGHDVARLIQTSRSMDNDHLMRVLLNKQRKLERHKAWKKRSRKRVKHEQRLVEKRNKQWIKEIEWKVTTAKVQKDTKDQKERETRTKIKELSRLLTKLTELRNLRRKKLESRGHFFADDGNEFFNKVKEWHEQQEKGEPERKELIIDEQDHWKHMELDKTAYEYWCQANQSTSALLRIRKEWDQYIWKNHERDEKDPVGKIPPTFVKPSPPANWSFFCLQPVVSRQLELVKLLKVDALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSS8</accession>
    <name>A0A367JSS8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000760">
        <property type="protein sequence ID" value="RCH92945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSS8"/>
    <dbReference type="STRING" id="86630.A0A367JSS8"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016486746" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="24"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="624" mass="70407" checksum="4D44D3F5EA68F0E0" modified="2018-11-07" version="1">MLPFSKVTSTLVLFLSLSSLGSAFYLPGVSPNDYHIGDQVALHVNSLTPNFGKSVISYDYYNPKFHFCKPGNNTIEQPESIGSILFGDRIFNSPFELRMIKDEKCKLLCTTETIPAEDAKFINSAVMNGYAINWIVDGLPAATEDVDQETNKAYYSIGFRLGTIFNGVPYLHNHYNIKIHYHTTSRNLHRVVGVIVTPESRDIRAGAEGDDMCLEEVGRFHLNEDGKSKVTYTYSVTWTYSSTVWATRWDGYLHVLDPSIHWFSLINSIIIVLFLTGMISMILLRALHKDISRYNALEAQEDVQEDYGWKLVHGDVFRPPNHAMILSVLTGSGVHLIAMTGLTLVFSVLGFLSPSNRGALATMLILFFMVFSCVSGYTSSRIYKMIGGENWKLNMVLTATFLPGVLLGGLLGLNFFLIYSNASGAVPFGTMLAMVALWLIISFPLSLFGSYIGFRKPRIEQPVRTNQIPRQIPDQPFYLRPIPSILMGGILPFGAIFIELYFIMNSIWFHRIYYGIGFLFLVFGVLIMTCSQVAILMCYFHMCNEDYHWSWRAFLTAGATGFYVYAYAFLYYFTKLDINSFTSTVLYFGYSSIISFLVTVMTGSIGYLSCLFFLRKIFASIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUB4</accession>
    <name>A0A367JUB4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 8">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MSH4</name>
        <name evidence="12" type="ORF">CU097_012922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000686">
        <property type="protein sequence ID" value="RCH93530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUB4"/>
    <dbReference type="STRING" id="86630.A0A367JUB4"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03243">
        <property type="entry name" value="ABC_MutS_homologs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="10">
        <location>
            <begin position="256"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="612"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH93530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="823" mass="91593" checksum="BAD2DEE057A48AA2" modified="2018-11-07" version="1" fragment="single">MDKSKQLSSVITVSSSRVSLPGSSNATKSVYTQRVTQQASNRPTAGGVSARPKTATTAVARRQAPKCIMSVTEGGGVAVEVGICIFDVNSCECTLSQFADSTTFARTIQKINLNDPQKILVSSFGNKSSEEIKERSKLYQLIEQQFPHVSFIFLPRKYFNDEMGIDYIKHYGLQEDIPGLLVGVSPKYYCLAATSGTFYYLLQNESLAFAENTIKFSYQGAEGNQYAKFVLNFWITYLDTITSRNLELVTNIINTNKENTLLGILDKTITPMGKRLLRMNILQPSCCLEVITDRLDAIQELSASETCLFNIQSSLQPLSDLDYMISFIVKLPNANNKSVGRQMLAVHHSESKINQAICLKQSIKSIQNIAFQLPCHSNPDGSCVLSTAIYKILSEPIFAELEEIINNVINEDVGIERTGLGLRNQKCYAVKAGVNGLLDVGKQAYKEAIEDTYELVSEYSETTGLKMKLQFSASSGFFIQMPTSELSDGNTLPDKFINVVTKRKMLHFTTLEILQSNSRINESLMEVYLMSDKVVSELLQVFRDNINILYKASEAIALLDMLASLASCKLSYGYVRPTFSDVLAIKSGRHPILDHILTFPLVPNDTFASLSSSFQFITGPNMSGKSTYLRQVALLNVMAHIGSFVPAEYASFRLCDQLLSRLANDNILSDTNTSSFMTEMKETAYLLQHVTSSSVVIIDELCRSTSPNNAVGIAAAVCEELAKTKAFCFFATHLHELTRTLVIYPNVVNLRLKVDVRMDDRNCMVDYQYKIEDGHLSTEQNYGLQIAQLLGYPKSLLLAAYQIVKELKKNKQTAYTNEKAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVS9</accession>
    <name>A0A367JVS9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000617">
        <property type="protein sequence ID" value="RCH94102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVS9"/>
    <dbReference type="STRING" id="86630.A0A367JVS9"/>
    <dbReference type="OrthoDB" id="2416276at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="550" mass="64663" checksum="DC71DC2C6EC81AC1" modified="2018-11-07" version="1" fragment="single">MASAFGFINKSNKQVKRKDLFSSEVVEPLHESSNFSSFVNQTPHASFSFGQNAQLEHSTFENIQSNRPLFGQNVSSRRLSFGQNASSGRPFFTQNVPSKRHNFRQSTQPEEIVFEHFGGPSFQDFKPRALATASKDIINTTENSTRQKKYRWETFQEKKKFKRTHLQGLYSKQQHIHEQIQKIKQKLDHTLQLKQDAIEKEQFLSVRDFQKQADQYKKQLDTLANTNLHDIQSQIRSAWKEMAEILAEEPEKSNDMVDILEEEKKKRQQIFDQYTKKIDQQDAQLLEGIKEKRQDIESQKSEIALDLELWNRSDAELQERMYETVLEETEKKNELEKMTNQIQDEINELLEKVKALEQEKKKYKDTIAKLDEAIETKLKPVKKERREHEQELELIKKRQKELNEKSAQLDKEDARINIEIERHSQEKSKGLKELEELERNIAFVASRQLNGKQEAEELLNILQSSIERRDQAIDNERARLRQAKENLLANTKVINELQSTEYAQEQQQLQLDYNISKLTAWLNNLNIQKRLAIEADQYEKAAEICDQIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWC0</accession>
    <name>A0A367JWC0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSP5</name>
        <name evidence="8" type="ORF">CU097_014210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000604">
        <property type="protein sequence ID" value="RCH94207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWC0"/>
    <dbReference type="STRING" id="86630.A0A367JWC0"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="57" mass="6330" checksum="4EA49D55A3FD72CD" modified="2018-11-07" version="1" fragment="single">GSDGPRRFTIEKAGEITQLPKAHTCFNRIDMPPYKSYEALVAKLTMAVEETVGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX59</accession>
    <name>A0A367JX59_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CDC55_2</name>
        <name evidence="5" type="ORF">CU097_013850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000564">
        <property type="protein sequence ID" value="RCH94564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX59"/>
    <dbReference type="STRING" id="86630.A0A367JX59"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000160">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH94564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="440" mass="50448" checksum="124DDC8F8E10C6B8" modified="2018-11-07" version="1">MQAVPTSTNNENKWRFAQCFGDKGESDDITEADIISAVEFDHTGDYLATGDKGGRVVLFERNENKKGCEYRFHTEFQSHEPEFDYLKSLEIEEKINQIKWCKRQNSAHFLLSTNDKTIKLWKVYERSLRVISESTMITEKPKLSLPKMSYQDTIVAAIPRRIYANAHAYHINSISVNSDSETYISADDLRINLWNLDISDQSFNIVDIKPANMEELTEVITSAEFHPQHCNLFIYSSSKGTIKLADMRESALCDQNAKVFEEAEDPSSRSFFSEIISSISDAKFSNDGRYIISRDYLTLKIWDVNMEKKPLRTINIHDNLRSKLCDLYENDCIFDKFECSFSGDGNNLMTGSYSNNIHIFGRNDDSEVVLQADKSVFKSKKLGGAKAMNNRTIIGQTRATRREASDYMDYNKKILHASYHPRENTIAVAATNNLFIFTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXE4</accession>
    <name>A0A367JXE4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NAT9_2</name>
        <name evidence="5" type="ORF">CU097_012790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000551">
        <property type="protein sequence ID" value="RCH94672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXE4"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH94672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="220" mass="25692" checksum="CC7728A5C8AB3581" modified="2018-11-07" version="1">MKINENLILIGQLVALVPYKPEHVPKYHEWMKNPFLQEMTASEPLSLEEEYEMQQSWHQDDKKLTFIITALPTDSPVHLKDIPKEEVKDKTVMIGDVNIFFNDPDDDPTFGEIEVMIAEADYRKTGRGREALRIMMGYAMEELGVKTFHAKISLKNEPSIQLFESKFGYYPVSVSEIFQETTLEWSLLDNTTSKDHERIIKVQQEILNFFHNHVDSITWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXE5</accession>
    <name>A0A367JXE5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CU097_005407</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000560">
        <property type="protein sequence ID" value="RCH94600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXE5"/>
    <dbReference type="STRING" id="86630.A0A367JXE5"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="21">
        <location>
            <begin position="99"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCH94600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="377" mass="43463" checksum="24B116D661F49B67" modified="2018-11-07" version="1">MRLYMNKGDEPSKRVKTLMGHDHISSSSSSSSSSSNSNSSSRRISISSSSHSSHNRVNQQEEGPFNNDNNNNETTDNSCSNHDDAKTRRESPPPQIIDTPEPNVNKLVYGKYEIEAWYYSPYPTEFGSKIDRLYVCEYCLRYMNKEAQLESHKAICKEKKPPGRMIYANGKIKVYEIDGQEHKLYCQSLCLLAKLFLDNKTLYYDVEGFKFYVLAEQNSKFKSYEELIGFFSKEKLSYDNYNLACIMTLPSHQRKGFGTLLIELSYELSKHEGKVGSPEKPLSYLGALGYQSYWASAILATLLHFRGDVTIEQISKETCIHEQDVIDTLSRLDLLRFRKKDQDRDHICITENMLNETINTRNIKIARKIDPSLIRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXL5</accession>
    <name>A0A367JXL5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000551">
        <property type="protein sequence ID" value="RCH94673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXL5"/>
    <dbReference type="STRING" id="86630.A0A367JXL5"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="257"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH94673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="338" mass="38805" checksum="09FD3C27CE000E7C" modified="2018-11-07" version="1">MSEIITLLVKHVPDFITQSPELQKNYFKPYKPIATRFMQTAAMPGFVFIDFANRHAAEEAYKELKKIHFGLYFKQIQVEYAKPDPSGQKELPSSTPSESPEPIAPLQGIDYPSNPHLRYLYPDPTPEILTNITHAIGSVPRLYTQVLHLMNKMNLPPPFGPLVKHAVPTLRKRKEDALLSSDESELEEETPQDTSKEQEERVKEARQARIAAEKQRLALKKAKENQQIQQIQRQCLPLEQLTHLAAFKNYEPGEVSNRLYIKNLHKKTTEQELIQIYSVFSNDIKVNLMTKGRLRDQAFVTLPDENVAKLALQSTNGYVLHDRPMAVVFSKNRDKVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYH7</accession>
    <name>A0A367JYH7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000517">
        <property type="protein sequence ID" value="RCH94983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYH7"/>
    <dbReference type="STRING" id="86630.A0A367JYH7"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="536" mass="60686" checksum="97F376EC7883215A" modified="2018-11-07" version="1">MAHPQVILERLQARDVREGIFHELILANNQLLQQAIENKKKDKKRKEELISEGSLQNVAELDRRIRELSEERAEMYKTQSENAQRLIHLSEQLRIKEDKEKRQTKELIQLSDQVKKLSAKCELHVYQLKEKDVTIQILQDELTALQLEITTTEEKNKNLSIENKQLLQRWMDLKNAEAEKMNEAMQFYEQALEQAKNSPDRKKSQPKEALSSYNLLPSKVYKKINAHDDDIHCIAASSKGALFATGGADRKIRLYDTRSGHMIQALGGALQTITSVSFNSTDEMILGSCTDNATRIWSLSTHRLRHTLTGHIGKVYAAKFTGDSNRVVSGSHDRTLKVWDLQRGYTVRTIFTFSSCNDLCLMDSDGQTLISGHLDNHIRFWDTRTGSGIKELTGVHNGQITSVSMSSDGMYLLTNSRDNTLKIIDIRMYDILKSFQADSYHNGLNWSRSTFSPSGSYIAAGSSGKMHNGPNAIKCLSKRILALLDGTLFVWNVNTGKVERMLKEHRSAICGVSWNPTGDHIFSAEKNKAVCIWDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ91</accession>
    <name>A0A367JZ91_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_009584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000485">
        <property type="protein sequence ID" value="RCH95253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ91"/>
    <dbReference type="STRING" id="86630.A0A367JZ91"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH95253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="470" mass="50714" checksum="EE101A2F5F14C4E0" modified="2018-11-07" version="1">MDSSSPTYQTGDVAWILTSTALVWLMIPGVGYFYSGMARQKNALSLIMACVLSLVVVSVEWFIWGYSLTFSKTSTSSFIGNLDNAFLRGVLGDPSIGSSAIPDLVFCIYQCMFAALTPALAIGAAAERARLLPMVIFIFIWSTLVYNFIAYWTWNPNGWSAKLGAVDFAGGTPVHISSGAASLAYALILGRREGHEEKKEEFRPHNMSNVVLGTAFLWFGWFGFNGGSALSGNLRAAMACVVTNLAASVGAITWMCLDYRIERKFSALGFCSGAVAGLVAITPASGFVGPAPAVAIGFLGAVACNMAVHLKHWLKYDDVADVFAVHGVGGYVGSLLTGIFAEAYIAHLDGATVIEGGWMNRHFIQLGYQLADCTTGMAWSFVVTYIILFIMNKIPGLSLRVDREAELRGLDAAEIGEMAYYHVDKIVGVNQTTGEEKVIQQEIQGYPYHPQAQGSMGSERPLTKDSLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZQ4</accession>
    <name>A0A367JZQ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000463">
        <property type="protein sequence ID" value="RCH95472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZQ4"/>
    <dbReference type="OrthoDB" id="2282250at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="35141" checksum="DE6E927FEAAD082C" modified="2018-11-07" version="1">MTGISEELVRYKLPSEFCPGIDTISKLMLQDQSILNLIAKAVVSVPNNTYVTSSTSGHFAKDVILATCDSVQEELNKDKLLFIPALANFFTSGKRKFDNVLATSKFLAIISGEDSVVDLSASSNANINNCCRQEYKASIGIGQLSELTLHSVATTPHLNGSQYCDAQLGLLNQHNDARQERSTTLLVLILASTLGLIKVDTTPVAFSIHLKLDMAEIVLDDTENRERDTLFLSFIFEEVVGYTATSFLRAPVMHQFKANSQVRARQRRALTDVVTLNKRDNNALDSMQQTSPTSQQLIILRFSQNDGPNHLGMILGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZZ9</accession>
    <name>A0A367JZZ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase subunit of RNA polymerase II carboxy-terminal domain kinase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CTK1</name>
        <name evidence="13" type="ORF">CU097_004379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000460">
        <property type="protein sequence ID" value="RCH95498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZZ9"/>
    <dbReference type="STRING" id="86630.A0A367JZZ9"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="210"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH95498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="536" mass="60912" checksum="77F3F2C237458087" modified="2018-11-07" version="1">MEATIVIIVVVVIEIKGEITETTVEVADPLEIIVTEVERDLPGLQEGQVENVAVEKKDPTTEEMIITTAQQAAAHASYYHDPQQQQQQQQQQAWNYYGWADYNNYHQTAEYTAEQYQQYAQYYYAYYDPNYYHQQQQQEVPPPPPPSSSSMEQPPPPPPPPSTDYMPSSTASPQISQSTNDQTIKEDISEESFSELGYPFETNDDPAVLFEKIGQVGEGTYGKVYKARNGKTGKLMALKRIRMKNEKDGFPITAVREIKLLQKLKHEKIIELQQIMVSKGCVYMVLEYMDHDLSGILGHPNFTFQPSHAKSLVKQMLEGLAYLHHMGILHRDIKGSNLLINNKGELKIADFGLARVFEKNETQDYTNRVITLWYRPPELLLGATAYGPAVDIWSVGCIMLEFFTGKAIFNGVDEISQLDSIYRIMGTPTVDTWPTLTELPWYELVRPTEVYAPKFKELYGSLLSPGALELSQSLLSMDPQKRPTAAEALEFAYFKTEQPEPVMPANLLDIQGDWHDFESKQRKRQKALTNSANKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0K5</accession>
    <name>A0A367K0K5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000468">
        <property type="protein sequence ID" value="RCH95431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0K5"/>
    <dbReference type="STRING" id="86630.A0A367K0K5"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32401" checksum="D91C9F4E41034521" modified="2018-11-07" version="1">MLNILKGKEQKIGPSLYPIRGLFHLFHHPKKYSGPILLSILKVVASSAITVIPLIRYGYGFQLSIIRKVYQTLLEPQTHRTAISFLVPATAGILCCAEAAAITIQLGTYFVGSIRTRLFDAILQERNALPVKEDDTTQIAEIVGGPAQNRDDLRDHAYLSPQSIAIITAQQDDDSWGAFFLRPAIFIMTLPLNIIPVIGPAGFICIQALFRAGEAHRRYFNVYHWTPAQVHRRIEQKFVEYFQFGLMATVLEMIPFVGYLFIYTNQIGGAMWAMDLHDRKLLEPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0X0</accession>
    <name>A0A367K0X0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_013696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000426">
        <property type="protein sequence ID" value="RCH95853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0X0"/>
    <dbReference type="STRING" id="86630.A0A367K0X0"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="337"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="60329" checksum="DA0086F369A36442" modified="2018-11-07" version="1">MLAANGSQERILDNNKDGQTVISTLTNLEGGFQCLLDKVKSDTQVAKDVTLFLKKRAAIEEEYGKQMIKLAQSMSESFDKGHLNLRSFGTSWLSFLKVHEKIGEQRMKFASDIIEVADDVQIMCKDTEKGRKQIKELGLRHEKNRIDAEITLEKSKQKYEQLSEDWEKAILNRNQNETDHNPKKTGLFKNNKTPAQLKKQEDESCAKANQAYTAYKNQLQSTNATRQEFFRSQLPSNILALKGLDDECCTAIRYQLARYAYIYEEALVLDGLALDNDEGNGLRSLTEKIDHGVDTEELVKEFSRKAQPLNKEDIQYKEYVMSPLAMNILKPNPVFGVSLIKLMERDKREIPLIVTKCVEAIEEYGLKSVGLYRLSGTNTHIQRLKNEFDFNCEEVDLSSEENRNDINNITSLLKLWFRELPDPVFPRSSYQHFMNAAKIENERMRVLGLHTIINDLPDAHYATLKYIMRHLDKVQQYQEYNKMTTSNIATILGMSLMGGDENHIVIVQTVLENYRLIFEPDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1C8</accession>
    <name>A0A367K1C8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000413">
        <property type="protein sequence ID" value="RCH95986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1C8"/>
    <dbReference type="STRING" id="86630.A0A367K1C8"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33242" checksum="B5B571DB4ECD1F45" modified="2018-11-07" version="1">MLGQTVLALFFTENAMMNALLATTYISVIPNLLLYFVPPNIKLTTLNTLVHFAIGSLLGDVFIHLLPHAFSKHQHDHHDQNNEHKHILVGISTFAGLFIFYASDKIMRSMYGNKSHSHSHKDQKEKKGHEKIIQASTYLNLLADFTHNLTDGIAMAASFYASPAVGATTTIAVFFHEIPHEVSDYAILIKSGFSKKRAMMAQFTTAIGAYIGTLIGIFIEETAIQFLDHHHRGLLGTDMTWGDLTIPITAGGFIYIATVGVMPELLGHHHSKLQALKELTAMILGIGLMAIISWKEPHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1W6</accession>
    <name>A0A367K1W6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000398">
        <property type="protein sequence ID" value="RCH96139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1W6"/>
    <dbReference type="STRING" id="86630.A0A367K1W6"/>
    <dbReference type="OrthoDB" id="2439595at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="467" mass="52203" checksum="D39A515332051BB1" modified="2018-11-07" version="1">MALVPLGFYFYNLSLFPSALAKKDMQTNLAKEVTDVPAASSTEQQNVNVDNRTTTEPSEEDTVAKADSNASLSDNKPVAENVALENAAATTSNTTLVPTPASNQQQQNAIPTATATATATTTNITTATSAPVDNAPVEQPVINRANEILISKIKQKREIVKRLDEELYFLRHYNADLIEKEKTIQERMMQRKKDQQQLLINYNEHIRSRRATDDDPSTIRTKLLELKAMIKDLSIDLASQCDPKVASAAIGSFWINLNEAIAKLGDPIPMKRIVMLTEKFLMDVLVQSMNYNTFPGLKISQPYTQLQFWFDRYDPAFCTRLRQEVAKAVVAGNTPNSDIQADIAKFNKRMYNSLYSSLLKAYPFMDQHDSREQDSKKRYSTIVNKMVELASYIGYTIRGQEVEIAAAAVGEGSEPLDLKTMNDEDNQTSGIIQFCVCPPFVVYGSRIEVLEKARVLCSPLPANYNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K338</accession>
    <name>A0A367K338_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF6_2</name>
        <name evidence="5" type="synonym">TIF6</name>
        <name evidence="6" type="ORF">CU097_013411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000354">
        <property type="protein sequence ID" value="RCH96598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K338"/>
    <dbReference type="STRING" id="86630.A0A367K338"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="26441" checksum="C8DC0BEE93ACAD65" modified="2018-11-07" version="1">MAVRAQFENSNEIGVFARLTNSYCLVALGGSENFYSVFEGELGDVIPVVHTTIAGTRIVGRLTAGNKKGLLVPSTTTDQELQHLRNSLPDNIAVQRVEERLSALGNVIACNDYVALVHPDIDRETEEIIADTLQVEVFRQTVADNVLVGSYCAISNQGGIVHPRTSIQDQDELSALLQIPLVAGTVNRGSDVIGAGCVVNDWCAFAGMDTTSTELSVMESIFKLQDAQPTAIVNELRDTLVDTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3P6</accession>
    <name>A0A367K3P6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosylphosphatidylinositol specific phospholipase D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPLD1_2</name>
        <name evidence="12" type="ORF">CU097_011070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000333">
        <property type="protein sequence ID" value="RCH96833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3P6"/>
    <dbReference type="STRING" id="86630.A0A367K3P6"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004621">
        <property type="term" value="F:glycosylphosphatidylinositol phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="FG-GAP" evidence="9">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="628"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH96833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="898" mass="100488" checksum="47DB71E1294789A6" modified="2018-11-07" version="1">MSHGMADVKWHSLGGLSDYFIVALANSDFHGNFEEAHMAADTGGEFTLRHSSRLSYLNETWKVPTRDLVEIYKRLYIDSSVKIPSEKHIQYCMTAAYAAAQINAEFGQWMFGVYGARSPFLVEELYDYYRGGIHDMSKSVSECYSQMIDGFEYGIAHGQPDVLCASYFNTLRDQSSTPQPRCLHNTIKQLKDNSRIETEYDPATGVLTLTTAMKNSDRQEESQHGTPIIVTQSMYQAMLQAPFVRLFPSHCTSLEDLVTLTIPSWPSGVGHQTVLGDFGATGQLDTAISAPYHDKAGAVFIVNSTVQRSLSGTQQDLTKLTETVLAGKEGTFGWAMVTVDFNQDGVDDLAVACPTENGGQVFIYFGQQGIGLSEEPSVQIELPFQGTVLAAIDIDQDGHLDLVIGCPLCPSNDYLQSGIVYIFKSRRDYASVLVQPDITIENPNMDPASYDHFGETILLVKNMLIISAPGYSQGSKQRVGKIYAFDRTNQLKWTMVGVREFQQFGRAMVTDNRDVLAISSPSEGTMIGFQRYWQAGTVRIYDLDKLLSSNQAVDMEYGLIKTLKGRTDAGHLGQSLSIVNQELWVGEPMSEKAATTTPTTTTSTTTTTTTTTTATAATRTRRNEPKIFRCTGYGDCNMVFSRSEHLARHARKHTGEKPYKCIVPNCDRTFSRIDNMMQHTHTHNRNRKKGFQEKKPSVPDDNMMVNVPPRSPKIEFQQPFNNLPPYEQRPLLPPPLPVQEHYYHYPPLLPPPPPSVLAPQGPYPWPYPSPPNTSASFVEQKKMDSPKKPLFQKLDSNSTRCIELSTPIQQLNDETSDTTDDERMSPMTDDTTTTVITADEYEALQGFGQFCTKPREYKEIPVRCIRFLPSQVYAFRQQVDLVQESFSRRTAGTTFYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Q8</accession>
    <name>A0A367K3Q8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_009197</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000334">
        <property type="protein sequence ID" value="RCH96818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Q8"/>
    <dbReference type="STRING" id="86630.A0A367K3Q8"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH96818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="449" mass="49163" checksum="B568A1F65668167B" modified="2018-11-07" version="1">MSVLEIARSARLASVSLQSVTNEQKNQALLRIKQVLSERRQEIFEANERDKQTAKELVEAGKLSSSLYKRLDICQGDKFDTILSGVSDITFLPDPTKKITLATKLDDGLELYRVSVPVGVLLTIFEARPEVVVNISCLALKSGNAVILKGGKEATQTNAALARVIQDALASLDTIPKEAVQIVETREDISALLDLDRYIDLVVPRGSNSLVKYIQNNTRIPVLGHADGICSVYVDKDADIDKAVKLVVDSKTNYTAACNSAETLLVHESLLGTDRFIKIADALLQAGVTLKCTSHVRDVLVNSDAITTKNKIEEAIDQDFDTEFLDLIMAVKSVPDVEAAVMHINDHGSKHTDAIITENRQTADYFMTRVDAAGCYWNASTRFADGFRYGFGAEVGVSTNKTHARGPVGLEGLVIYKYKLIGHGDIVGDYGTGKKKFKHESIDPSEYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K449</accession>
    <name>A0A367K449_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000350">
        <property type="protein sequence ID" value="RCH96641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K449"/>
    <dbReference type="OrthoDB" id="2289168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="183" mass="20991" checksum="2CF176D266A16090" modified="2018-11-07" version="1">MNDLQSNTISEEQESLLSFLQTNGMMGTNDTNLATIEPIHDVEFLAYLANFSELSSDNSVSSTEEEKRKRNRSTRVGHCEHPKHVFYREEPFIFEQGHHLIKTIPRRGRPPKGSKPGDTKQKNGYRMVALTVRSLPKRLEAVVGRSNIKVCLTCLKKSDMDPEYLASESYIAPQQLFRHQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4A7</accession>
    <name>A0A367K4A7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000344">
        <property type="protein sequence ID" value="RCH96701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4A7"/>
    <dbReference type="STRING" id="86630.A0A367K4A7"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11951" checksum="4B396AB192ABD599" modified="2018-11-07" version="1" fragment="single">MSRLHLFQKVVNVLVYLFFLSATVYSVVGPAPSDDVEHEGQTYITPSYWIAYIWSLIHFLLFGFIIYQWFEPAHEAAIHGVGWHFVISVILSSIWLGLLINFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5T8</accession>
    <name>A0A367K5T8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RMT1_2</name>
        <name evidence="9" type="ORF">CU097_013632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000270">
        <property type="protein sequence ID" value="RCH97528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5T8"/>
    <dbReference type="STRING" id="86630.A0A367K5T8"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="160"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH97528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="337" mass="38266" checksum="593FBFC104767C95" modified="2018-11-07" version="1">MAASTPSHNVETMTSKDYYFDSYAHFGIHEEMLKDEVRTLAYRNSIYNNKHLFKDKVVLDVGCGTGILSMFAAKAGAKHVYGIDMSNIIHQARVIVKDNHLDDKVTLIQGKMEEVVLPVDKVDIIISEWMGYFLLYESMLDTVLVARDKYLAPGGMIFPDKATMYIAAIEDGDYKEEKIHYWDNVYGFDYSSIKNLALKEPLVDVVDARNVVSTACPFKEIDIATVTKADLTFKAPFKITATRDDYAHAFLAWFDIGFTHCHKPVNFSTGPHAKYTHWKQTVFYTPETLTLKEGESIEGEVSCAPNQTNPRDLDIIIDFKLDGQHGTIQDKCEYKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7S4</accession>
    <name>A0A367K7S4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000214">
        <property type="protein sequence ID" value="RCH98220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7S4"/>
    <dbReference type="STRING" id="86630.A0A367K7S4"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="27185" checksum="C447080B31514F27" modified="2018-11-07" version="1">MQGLPDFDLTLNPHAGVDDWQYEMRREIQEIIPGVFLGPFSACRRIDQLKEKGITHIMCFIDQAEARLFKTDTLMQHFEFQQYIVNDTILQNLIQHFPNVFKQINRALDLGGKVVLCCNGGMSRSPAFVIAYLMERFNLDANQAYHCVQARRLCINPNDGFKCQLKEYEPIFRARHGAPSIDGDSRRRRRSRGEENDDIFKHTHGVDPKRYLRDQIHEEQGTNAMSPEYSSMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8X8</accession>
    <name>A0A367K8X8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000179">
        <property type="protein sequence ID" value="RCH98674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8X8"/>
    <dbReference type="STRING" id="86630.A0A367K8X8"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000017">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="310" mass="35411" checksum="86A2910AF38F4FEC" modified="2018-11-07" version="1">MTEALVSIPTFSKLSSRVWRVLGLNPGKVTLQGTNTYILGAGAQKLLIDCGQGVSEYTPLLENSLKDIQADAYISDIIISHGHFDHWGGLHDILSSSILNPKKQIRVHKFPLPSGKHIDHLKDFPQDISVLPLKDEQTFKVDDATLKVIYTPGHTSDHCTFWLEEEKSLFTADCVLGQGSTIFEDLHQYLSGLDKLARLQPRRLYPGHGPVIENGTDKINEYIRHRLEREDQIIQLFNQQDGWTPMEIVKVLYKDYPESLHLPAARSVVLHLYKLHKDGKAKTAKHYDFVQENYPHIINSKWYWVNQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9K3</accession>
    <name>A0A367K9K3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POLR2F_3</name>
        <name evidence="7" type="ORF">CU097_010149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000169">
        <property type="protein sequence ID" value="RCH98809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9K3"/>
    <dbReference type="STRING" id="86630.A0A367K9K3"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="18478" checksum="F0C801F26D5C05CA" modified="2018-11-07" version="1">MDYDDDDVQDYQDYEPFVEEEPYDELPVEEPALYDEELQTTTNNGDISTEPMTDRIDILNDVMSGGNIRQREQLPDPNERTERLTTPYMTKYERARVLGTRALQISLNAPVMVELNGETDALAIANRELREKRLPLTIRRYMPDGTYEDWKVRDLIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA83</accession>
    <name>A0A367KA83_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000148">
        <property type="protein sequence ID" value="RCH99076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA83"/>
    <dbReference type="STRING" id="86630.A0A367KA83"/>
    <dbReference type="OrthoDB" id="2290200at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24873" checksum="183992E86506AC8E" modified="2018-11-07" version="1">MATSACTEYMLKENLSGASYTFSIIYENNEHAGIVNSFYQDFGVDFEKVAKIYSPDADGNCGYRAISMAKYKDTPYANRVEDSDSFKKSLSCNLSPCPIQYWFNTTDCPQIAAGAFGRGIAVFSKTLFNGKPFITSSFFAPLASEPTNYTIINILLDHNHFYLIETARTKTGRPVKFPIPTLNPYHKAIIKRNPALCVRDYSIVFEFITVTTFINNFTINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAM0</accession>
    <name>A0A367KAM0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000132">
        <property type="protein sequence ID" value="RCH99293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAM0"/>
    <dbReference type="STRING" id="86630.A0A367KAM0"/>
    <dbReference type="OrthoDB" id="2272836at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="36312" checksum="74849BEF65496DB7" modified="2018-11-07" version="1">MTNQSPHPNSLSPQSKHPQSAFQWPIPPLSQPNSSPEISVREILDRYSDDPELLKYILTAKSEEDKKKAARDTLKAEEARIQLRQMDLEIAREQSKSRTATTAQPPPPTLVYGLAPVQQQVLARFNYPQHLTHQQQQQQQQQQRQSEQQQYHQQHRPPPSPGIPYPHSAHPLFPPSSSTDYRVQSSEEKSSLKRNRSSISNETEQVSDKLSHDKVMEALKAKIQRSSNNPQSPLSASKDTKKKKQPPRPIMKVDLANRSPSSNSPRSAKPVLPPIDTNLGRLSQPARTEESSSNNNATNSSADSSDKLSPVHYRRSRSLTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB84</accession>
    <name>A0A367KB84_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000121">
        <property type="protein sequence ID" value="RCH99475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB84"/>
    <dbReference type="STRING" id="86630.A0A367KB84"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="40585" checksum="AEDBA05DA93EFC12" modified="2018-11-07" version="1">MGNNISAKSRAIDKQLKLEKKKAEKEIKILLLGAGDSGKSTIIKQMRLIHASGFTKYERESFRLMIFTNILGSMQALLEGMHHHKFTFENEANWKYIALFERRPASLSMHEPYPIEYLEPLKSLWKDKGIQATFEKSNTFAFNEDVYYFFDQLDRMFRPDFVPTDADIIHCRIKTTGIVETKFRNGTVTYRMLDVGGQRSERKKWIHCFDNVAAILFVVALSGYDCCLVEDKYSNQMYEAFMLFESICNSKWFINTSIILFLNKNDLFKKKLLKSRITNYFPDYRGSPTDYNQAKEYFKNRFLTLNTNYEKQIYVHFTVATDTQLLAVVMESVSDSILQENLQTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBF8</accession>
    <name>A0A367KBF8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIM8</name>
        <name evidence="7" type="ORF">CU097_010015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000115">
        <property type="protein sequence ID" value="RCH99554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBF8"/>
    <dbReference type="STRING" id="86630.A0A367KBF8"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="85" mass="9893" checksum="CD68CEAE8F8BFFCC" modified="2018-11-07" version="1">MSQQLQFSENDQRELGQFLEAEQAKARVQQTVHSLTDNCWDKCINKVNNKLDRSEEACLANCVDRFLDTSIFIVKRLEELRNSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBZ1</accession>
    <name>A0A367KBZ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SSN3</name>
        <name evidence="19" type="ORF">CU097_015505</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000129">
        <property type="protein sequence ID" value="RCH99351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBZ1"/>
    <dbReference type="STRING" id="86630.A0A367KBZ1"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH99351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="385" mass="44305" checksum="A4E486D6191B6EC3" modified="2018-11-07" version="1">MSMIDYKKRKDARRPRVLDKYEIIGFISSGTYGRVYKARSRNKDDPREFAIKKFKPDREGDTHHYVGISQSACREIALCRELKHENVVALEEVLLEDKAIFMVFEYAEHDFLQIIHHHLHAQKKPIPEIVVKSLLWQLINGVAYLHANWVLHRDLKPANVLLTSDGVVKTADLGLARLFNKPLAPLFNGDKVVVTIWYRAPELLFGARHYTKAVDMWAVGCIFGELLALKPIFKGEEAKIDNKKSVPFQRSQLTKIIEVMGTPTKERWPSIDQLPDYPHLASFPQCPNNLKQVYQMMVCPKSESAFNLLSALLEYDPAKRITAEKALNHPYFQEDPKPIMNVLAHQNIEYPLRRITHEDNDIKSAKAPAKEDLHASRQMKKPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCX9</accession>
    <name>A0A367KCX9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000084">
        <property type="protein sequence ID" value="RCI00038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCX9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="17887" checksum="05A6DB00CCB60A7C" modified="2018-11-07" version="1">MVIPKNHPQKPLKSKKKMLLDYISNEEAVDGLESAMACRPTEHCCPPSPTVATNVAATILRLLQLMDILSMKKCRDEKEYKSPHPRSKKINATDELQSCPLATESSSTPKLLTLQSRKDKRYVKIKTMSVKYYFVTGQSENGGPWKVTWCHPKSRNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE70</accession>
    <name>A0A367KE70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CU097_015617</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000061">
        <property type="protein sequence ID" value="RCI00431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KE70"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1183"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1578"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1605"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1633"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="8"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="944"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="20">
        <location>
            <begin position="1845"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="765"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI00431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1903" mass="216565" checksum="EC58F76437E60374" modified="2018-11-07" version="1">MQDDSRIDLTCLLTSSSPPSEDNITHLLQTRFKRNQPYTRLGHSTLIVVNPYQPLEILNDATLSTYADIGYRNIVENKPFMQPHVYDLATRVYFHMRRTGEDQSIILSGITGAGKSTTRSHLLKQLLLLSTHSKKETKLGLQIQNAQIILEAFGHTRTSQNNSASKFGMFQELQFSERGRILGAKTLTYAFDKSRVTQVPKDERTYNVFYSLLAGTSVEEQTALHINFPPESFHYLSQSKVIKQPEDEVAFADLKNALKVCGFKAKTVTQIFQLLSAILHIGNLQFQGDDSSQQTQEACSIRNYDTLEMVALMLGVSPSKLEQSLTYKLRLIRKELCTMFLNTQGAAEQRDSLARALYHVLFLWIVETLNTKLCYSSEPANFIGILDQFGFQNFKSNGFEEFCANFANERVHQFIIDQRFNNQVGINALMTRDGVPLPSIITMDNSACLELLVGKEQDHNIGSREKTKSAALGLGGIVGAMDRDCAKYQTGATDATNANFLANVQRLHSAHPSFSKSQHAYSFGVNHFSGTVHYTVESFLEKNLDDLSPDFVSLLRDNSTNTFVSTLFESTAMATESHPKDDRTIVKAQLTSKPTRAPSMKKPKRRDIIPEEDQKAIKDAEDAYQNMQVTTVMDQLYMTLRDLFYTMADTRIYQIIHIRPNDTLSPDLFDLKRVKAQVRAFLLSDLTARASVEYANYLTFSEFLVRYERLVSSLQIDHVKSERDQVEDVRAIMNWNESQVFIGHEMIWIAYDTWKELEDGLRAAEKEERERAKEAKQGMMQDAPVMPSQGYYPESQDRLMPPAAYGDPRGYDEASYVDSEDGIKRDMEGSQWGEESEWGGVKISDGFGPNMDMSKMVEDYHQPQHESVEEVPITAVRIWWVRFVWLMTFWIPSPFLRWFGKMKREDVQMAWREKVTLCMLIFFFSAVTIFFIVGLGEVICPGTQHMYSTANVAAHNLPDDMWVSVRGTVYDITNFAKIQHGAAGNIATTDLMDQIGGYDMSDSIPPPLTVACQGLVTSSTVKITANVTTVKASFIHYSGDQNSIPTLTKMSSPTWYWDYFLPTMSLYKKGQLVIPISSLYADYQSWSRLALAINGKVYDITDYMNTAKTYDSGSTSSTYHFLHATVEEIFTKFSGTDATDKWNQYKASMTAEQQAQNMACLDNYFYIGNVDERDTPRCMFTNYFLVACAALMGLVILVKFLAALQFGGAPTPEDHDKFVICQVPCYTEDEESLRKTIDSLTVMNYDDKRKLLFIIADGMIMGSGNDRPTPRIVLDVLGYDTKNDPEPLMFKSIGEGSKQLNYGKVYSGLYECEGHVVPYIVIVKVGKASERAKPGNRGKRDSQMICMNFLNKVHFDSEMTPLELEIYHQIKNVIGVNPSFYEYILMVDSDTEVLPNALNHMISCMLHDGRIIGLCGETKLVNEDRSWTTMIQVYEYYISHHLAKAFESLFGSVTCLPGCFCMYRIRTPVKNEPLIISPKVIHDYSDNHVDTLHKKNLLHLGEDRYLTTLMMKHFPQYKMKFTPHAQCKTVAPDRWKVLLSQRRRWINSTIHNLFEVVLLPDLCGFCCFSMRFVVLIDLIGTLSLPVSVVYLVYLLYVIISRTGPFPMLAIIMLAGVYGLQALLFIVKRQWQHIGWMIFYILAIPVFSFFLPIYSFWHFDDFSWGNTRVVVGDKKQKKIIVADDEKFDEKMIPLKKWSVYEQELWEMGSTGSKETRLTGHTYKSYQTHGSRNNPSIMYDSRTQYAGSQAGDYDYYRDTTIHENKRTRSPGYTGSVIAGSEYGGAATHDFMMTPPPMPRQQQAMSVHSFGPDYHEMNNTFDVPMRPTSQFSIPLSQGGMLPMLPPGFPSDDEILSEIRNILQTANLMSITKKQVREQLSAFFGYDMTPKKEFINTSIEYILKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF32</accession>
    <name>A0A367KF32_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000038">
        <property type="protein sequence ID" value="RCI00835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF32"/>
    <dbReference type="STRING" id="86630.A0A367KF32"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22125" checksum="239A597B06523FE6" modified="2018-11-07" version="1">MTEILLVCRVSAEQSIAGTVDRLSDGVFGRIVDDDGNELPPGSEGELRIKGPTITLGYYNQPEATAELFDEQGYLKTGDIFKADENGLLYYVIRKKDLIKYYGINVFPAEIEEVITGHPQVTDCAVIGIFSKEGTELPRASVSLLDKVSDKVSLLKEIAEYAGSQLPDSKKLRDGIFEISSFPRTGTGNIQRLKLQSMSGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF54</accession>
    <name>A0A367KF54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_005621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000042">
        <property type="protein sequence ID" value="RCI00750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF54"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="119"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="332"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="472" mass="52360" checksum="5572F7E741F1F8C7" modified="2018-11-07" version="1">MLKNEQRHQHKDYIELSIKNDEDEPPDHEETDEKNQQTEALLTKEEPQNYQENGSSSSDTFLYYEETDKKEESNENSLAIQAFPSLIISMIGLIFAGDLMDEFQSSDVFLKTPELFILLPILLNLKGNLEMNLAARFSTSSNLGELDYGTTRRSLILGNLSLLQVQSLVAGAVAGLASFALGLITRPGSNYPSYYEMMFMTASAMVSASFSAAILGVFMCALIVLCRKLNIDPDNIACPMASSTGDIVTLVLLAVCASLLQHQMETILSTVIVVGMLGMIPLFSVIVWRNKHVKDLLFAGWTPIIFAMVISSLAGIILEEYVEEYKGIALLTPVLIGLAGNLGSIYASRISTCLHAETKESYKTVEYTLLIMNLPVQAIYMFIIWIFGLGRLQYNFWFFITYFIVSMLSAWISLKIGKFMTIVFWKMGYDPDNYVIPYLTACIDVIGTILLVVTFSVLTSTGATDMSVSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFZ4</accession>
    <name>A0A367KFZ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000023">
        <property type="protein sequence ID" value="RCI01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFZ4"/>
    <dbReference type="STRING" id="86630.A0A367KFZ4"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30375" checksum="92D692A28931FFC1" modified="2018-11-07" version="1">MSATRHNEYSIQENGPLQPPPLPTHQIMTPSPTPTVKPPNMDLDAEKMSDIQYIDTEKGMKKRRMDNRNGCLRCLCCACCLPAWAAGIVWFIIIAIIIVVIVLGAVAGTFVMPKVDMAGVSTSPAEGGSQISFTGETFNINFGLIISVNNPNLLSIDLTDIKATAYYPNQSGKGRTRVGGGYLAEQFVPKYSNFNFTFPFAIQYNPTLDTDQSVLSDLASKCGLTGEKKQDITVDYTIHLTARVLFIKVHPTIDSSATFACPISANGALDGLGDGTTISGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG76</accession>
    <name>A0A367KG76_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hydrogen voltage-gated channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_015003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000037">
        <property type="protein sequence ID" value="RCI00852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG76"/>
    <dbReference type="STRING" id="86630.A0A367KG76"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23973" checksum="5FC5196B2F384835" modified="2018-11-07" version="1">MSYYGTLPTHTHEEEQEITWRHKLGEYLEDQKFHIGILCLTLVDAASVFIQIIYTFFHECHAPFNNIHDNTHWLIVAFEMAEVISVCICVLFILEITLSLIAFGPRYFLPGWPHWKLHVFDAAVVITTFVLEIVLKGKEREVAGLLIIFRLWRVVKVIEAVVLSMSFTHQEELEKLKERNEELQEKLKQVEQRNRELEQQVGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG96</accession>
    <name>A0A367KG96_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GEF1_3</name>
        <name evidence="12" type="ORF">CU097_015832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000019">
        <property type="protein sequence ID" value="RCI01244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1102"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="571"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="678"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1225"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI01244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1341" mass="149146" checksum="31175BDE9C8CF91B" modified="2018-11-07" version="1">MTGHGRTSSVEIEEELAQIRRYEDFTTTDWVKDAIIERYRQAAVKSSISSDTTWRAWWHQTFETAESWVVIFLVGAAIGLMSALITIVTDWLSDIKIGYCSTAWWLNQKFCCWQMEESDGGCADWTDWSEFVNLGPDVYIVKWLFYILWATTFATLCAYLVKTLAPYAAGSGISEIKCIIAGFVMKGFLGGWTLVMKSIGLTMSVASNLSIGKEGPSVHMACCVGNVISRCFKKFRTSKAEMREILTASSAAGVAVAFGSPIGGVLFALEEMSNAFPNRTMWKSFFCAMIATIILQAMNPFRTGKLVMFQVSYDRDWHFFEYIFVVIIGLFGGLYGAVVIKYNLLVAQFRKTTLKDFPIVEAAVLASVTAFIAYPNIFLRIDMTEIMGILFRECEGPGTESYYGLCESQEAWKMVILLFIATVLRSIGTIITYGARVPCGIFVPSMAIGAMFGRMIGLLVKLWHENRPDFFLFASCRPDMPCITPGTYAFLGAAAALGGVMRITVSVVVIMFELTGQITYILPTMIALMITRAVNDWFQSGGIADRYIRLNGYPILDSDDQVFGVPVSHVMQTNLTVMTASSMTFMEIERILETTNYQGFPVVEDLKSMALIGYIGRSELQYLIEKSKVNKKAHDETLCRFTPDASDEPEILTNIGLSDEGQHDLRGSSDALDFGPYMDQTPITVHPRLYLETVMDMFKQLGPRVVLLEERGKLKGLVTVKDVLKYIAHTENVRTSSNRPSNRECGGLFEIMTSWITDRPNRRRQQSYTRLQNRSSVDIEESHELDRQAMDTKEQEDIDNVAFNTFIGVLVSICGNALISVALNLQKRAHNKIQEKQMANYFSNMDESPQWIPSSGFFPDDGYSSPRSSIESSVTVPNNHNNNSQSEEELIERQKFIMTQEYDKGDNTDYLKSKLWWLGITLMILGEVGNFVAYGFAPASTIAPLGTTTLVSNAILAPVMLKEVFRKRDLIGVTLAVTGAAIVVLSSNSEEVALSPELIMDAITQTQSIIYFILTGIMVTILTILSPIHGSSSIMVDLGLVAIYGGYTVLSTKSVASLLSLTLFKMFTYPVSYLLILVLVVTAILQIKYLNKALQRFDSTEVIPTQFVLFTISAIIGSAVLYHDFDGMSLEQLSRFMAGCAIEFLGVYLITSKRPKRMHPALSISADSSHTAIMLPEHELPSEQQQQQHPLRASKRVSLILPTVNPSSAREDAVYTHPSTHSGHSNQSTVTNNSNNNASKRRSSVFRGISMASQLLDRDDEPCQLPSSQRDSGLFLNTTGNILAGLSSLIAEHQQQDLHDNDAVEIDIPTSFSLIDRELMPMTRGAENGDKKTSKLVDIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK37</accession>
    <name>A0A367IK37_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005494">
        <property type="protein sequence ID" value="RCH77993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK37"/>
    <dbReference type="STRING" id="86630.A0A367IK37"/>
    <dbReference type="OrthoDB" id="2207787at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16109" checksum="82A24991A26BB80E" modified="2018-11-07" version="1" fragment="single">PVLQKRSKASYITAAIALIIAQRLYSYFRVPKHLRGFPKLPYFGIAKSFFAKESPRERVKKYILPIIDEHNGFYISKIPLGWILYVTDPVAAKQLLLKSSVFPKNHRLIDDMGENLFIEFVGKDNVVLTNGDTWKRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKN6</accession>
    <name>A0A367IKN6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005357">
        <property type="protein sequence ID" value="RCH78193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKN6"/>
    <dbReference type="OrthoDB" id="2230257at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15652" checksum="90E5FC8B3B0CB9DC" modified="2018-11-07" version="1" fragment="single">LHGMKWKATYGYGEAKSAAQVAILCKDALDLQNMEGVLGLQVIGRTITFYVVVLPATGLYVMRELAKIKVPDCLDDLTKLIMDMPQALLVLDIFNRVCVPSIDPPMPTRHRPTITTTVLNSIFSSSQDRKRSCLLKRHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL93</accession>
    <name>A0A367IL93_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005175">
        <property type="protein sequence ID" value="RCH78428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL93"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="57" mass="6449" checksum="2849F01C4B9B8DBD" modified="2018-11-07" version="1" fragment="single">GLDMIIEEADQDGDVFYDSTEYAPGEYEASSRNSLKKQLDLNQVEINILVKANTKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPA1</accession>
    <name>A0A367IPA1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004470">
        <property type="protein sequence ID" value="RCH79483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPA1"/>
    <dbReference type="STRING" id="86630.A0A367IPA1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF0">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding" evidence="2">
        <location>
            <begin position="125"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="44046" checksum="FC7F66312C962390" modified="2018-11-07" version="1" fragment="single">ALVASLVKSKTVPTNSPHQKVDLSPDLVKAVTAELIKESSDSSSTAESQATIVDEDQTILLESRVKDALEYIFSTQNARLINANHAIGYVAYGLSDLIFLYPGLTGNDYLGQELKEYGQVRNAKNELVKLVQMDTRFGALQAVQGALAQDPTKRLTVLTSSNALLSMVPNLYALAAQRQPIVFHVAAQSVDQDLVVSPNVDAVLAAARNTGAILLSSSSAQEAHDMAIAAHQIAYSARLPVIHFFNGVSASKQIEKVNLTSYTHLAQLEAIKDIQDPYQVAQKALGQYKPFEYVGASDADTVLVTLRASASDSLQHAVGSTLAKVGLLNVRLFRPWSESDLIHALPKTTRRLVILEEGAGLYAFNGPLYQDVAASIRFGPLAHDQRPRLVSAQAATFDHLQAAHMVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPA4</accession>
    <name>A0A367IPA4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004447">
        <property type="protein sequence ID" value="RCH79517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPA4"/>
    <dbReference type="STRING" id="86630.A0A367IPA4"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="86" mass="9232" checksum="D45C2CDF717985F7" modified="2018-11-07" version="1" fragment="single">MRTGAKVRLVSVVGDDLAGINDTRHIQTLKGHNTAVYNALHSNTGQLVAAVADMDIFEHMDGVKVASIIQNEQPNLVCFDGNISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPM7</accession>
    <name>A0A367IPM7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004369">
        <property type="protein sequence ID" value="RCH79654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPM7"/>
    <dbReference type="STRING" id="86630.A0A367IPM7"/>
    <dbReference type="OrthoDB" id="2286466at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH79654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="342" mass="38537" checksum="01ABD50F9AA6CF99" modified="2018-11-07" version="1" fragment="single">FNNSQVFGFILVNSLDISPWSQSLSNMANNSTANSGSNTGSGSHLIRFLREIRDFSCSTNARLQDSNQIIQNPLNWLKQIERLKELGGVTDKEVLIVARDHLVGKAAAWFDVACSQVNTWSEFSTLFKKRFCIALEDYCWNQIYNLRQAEHEDVDDIDVRLRELFSLVGLTNEKLKIRLFLSAVDPVVACEVERNKTADKFKDLDSVVDAAAHAETVVRKYRTKDVFFPGPPVVNLSRNVSKKYQEQDWHSEDNQSVNTASTMEELLKEFKELKVSIVQSVGASNGASGGRNFRPFSCFYCKKEGHRKAECPEFLQKKKDAPKPPSVETNGANSSGKEEGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQP8</accession>
    <name>A0A367IQP8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004146">
        <property type="protein sequence ID" value="RCH80017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQP8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="51" mass="5993" checksum="B672F8BD309597DC" modified="2018-11-07" version="1" fragment="single">MEHITNINENLLLNEFALKIRTQEAERRRDNNNEFPSSIISEMEETPSADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISV0</accession>
    <name>A0A367ISV0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Creatinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003777">
        <property type="protein sequence ID" value="RCH80709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISV0"/>
    <dbReference type="STRING" id="86630.A0A367ISV0"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH80709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11783" checksum="E58FF4BED81422E7" modified="2018-11-07" version="1" fragment="single">MVTNTTDRLTRLREQMKVHGVDVFLVPSEDAHQSEYIAECDQRRHWISGFTGSAGFAIVTMTNASLFTDGRYFLQASQQLDDNWTLMKQGLPGVPTWQEYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU30</accession>
    <name>A0A367IU30_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003569">
        <property type="protein sequence ID" value="RCH81129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU30"/>
    <dbReference type="STRING" id="86630.A0A367IU30"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="242" mass="26753" checksum="6539AF668159A50A" modified="2018-11-07" version="1" fragment="single">MKLDTGQPPPPSPIPASPHKGCNSSTCCSPARLWRTLQNLIKQNDRKGLLAFFKDPRLEHIVRVALTSRVSNDGSLLPASQRHTLVRFASPQLATEALPLLGKRLTDLNALQLALLESSESTVMALLTQLKLHASTEEMKSFVQHVWGQGNTSLHLAVFLNRPRVVKALLDLGASVDCLNAKQKSVIDCCRDQSMLDILSPPQKKKVIQHKLPNMEPIVVKDEPVVAKDEPMVEPMVVTEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUN2</accession>
    <name>A0A367IUN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical S-adenosyl methionine domain-containing protein 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putative heme chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RSAD1_1</name>
        <name evidence="6" type="ORF">CU097_003391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003542">
        <property type="protein sequence ID" value="RCH81191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUN2"/>
    <dbReference type="STRING" id="86630.A0A367IUN2"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="COPROPORPHYRINIGEN III OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF5">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="379" mass="42894" checksum="2BF3E3E0A5F62514" modified="2018-11-07" version="1" fragment="single">MKTELGYFLNNTRFQLKHKKIHSVYFGGGTPSLAQPVVVSSLLSTLDEHIGLTKETEITLEANPTSAEKDKLEQFKQIGINRLSLGIQTFNQKHLKMLGRDHSVKEALSALEAAKRIFGSDRVSFDLIFARPGQTLDEWKNELKHALTIAGDHLSLYQLSMERSTPLHKQYLKGLVPAMPDHDLSADMYEETVRQCEAFGYSHYEVSSFAKTQKAISRHNFSYWQGIDYLGIGPGAHGRLTDVSANQRVRTFGEFHPDKYMALCESDGEGLRKITPIPFDTMAEELIVFGLRTRMGIPRSRFRELTGGKSVEEFLNKEQLNMFLEAGFLIDEQGLVDDRAQTYIPHELLSQWKDGGGIRPTEAGLERIDYILPRLLESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUW2</accession>
    <name>A0A367IUW2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003413">
        <property type="protein sequence ID" value="RCH81483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUW2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="77" mass="8263" checksum="515A3A91D788B063" modified="2018-11-07" version="1" fragment="single">AAEIAELQKAGKLPTSNSSSNNSSNNNNNTNESNNNNSNNNYHQVNGNHSSANGNTISTEDMKNQNPSSSLTNEFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV16</accession>
    <name>A0A367IV16_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003395">
        <property type="protein sequence ID" value="RCH81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV16"/>
    <dbReference type="STRING" id="86630.A0A367IV16"/>
    <dbReference type="OrthoDB" id="10483453at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="12060" checksum="4FF5BA82238D8B60" modified="2018-11-07" version="1" fragment="single">MPESVYGVPSTAMPSSRRQFRRNSAPGIDDSTFRPFSSPIPSPTTSAAKKTHQHRLNAAQEQRTYRDSCNRLLSHITSVVGICDDLKKANKDKYPMFYPMTRPSKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWV4</accession>
    <name>A0A367IWV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003124">
        <property type="protein sequence ID" value="RCH82157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWV4"/>
    <dbReference type="STRING" id="86630.A0A367IWV4"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12371" checksum="6AF7C34B748556AA" modified="2018-11-07" version="1">MDVAAGGPFSIVLTEDGHVYSCGYGALGLGPEMIESLELKEIKGLEKVAKVYASTDYAAALTEDGELYTWGLNGPSGRLGLGHHEHAFVPNRVNVDRKVLDVSLGVNHAMILCEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYX0</accession>
    <name>A0A367IYX0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002941">
        <property type="protein sequence ID" value="RCH82651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYX0"/>
    <dbReference type="OrthoDB" id="2264205at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="111" mass="12346" checksum="FB93710E698A5AB1" modified="2018-11-07" version="1">MVLRGPHPNVCASVPLTDETRRYLEVYITRQDCNDTVNNSLVFPDAKMKIFPCSSLENSAKTINLKLIFGTIMDLGIVTDPAAGFFIGSGYAVLNIYQNKNTSDVNRFQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1F2</accession>
    <name>A0A367J1F2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002564">
        <property type="protein sequence ID" value="RCH83756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1F2"/>
    <dbReference type="STRING" id="86630.A0A367J1F2"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15552">
        <property type="entry name" value="PHD_PHF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="310"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH83756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="760" mass="86957" checksum="CC9D062DFD38330F" modified="2018-11-07" version="1">MDIHNIDDFLNLQDQNEINLLAAEGIAPIQHNESEWHSVTSTPSDSFPTANNILYGTEDCNDNNHNSSNEPSNNNSNNWGFGLGFNFMHDNNNNVDANNFITPDSLLKQPQIQQQQQQQQPSEQRVTRSRSITLNTTPTVTYKKKKSRAKKLYCICQQPYNGKPMVQCDRCEEWFHCACVGFDPDAEEEDIDWICQKCEQETQQTPASDNNDNNDNNDEVAPNDNTRQTRSRQQSTCLYKGCNNHTRADSYCSDVCARKDEQGTPAVRRNTKKKETPPPPPPPEESEKEEPQESSTPNSPSQMTADENPVRRNVIKNMTGILKTIMESAVQKDPELFNVGEIPERAENLARSIESTMLEQLGDTKGRQRTCGEPYKNKFRSLLHNLKDKANQNFQLRVVAGDLTPLELIKMSSEDMANPELKSMSEVLRQKSLKNSILKIENVPIIKKTHKGDIIMIPNKEEKNQDDFYKEPLLENKNSSSNQQEIPVSDTVDHTSTKSAEPMDDILARIGVTNQEDQRRDPSSLNTGHRAKKRKVTVDVETLLGEEEETPFVVEEVDTTELENQESDQKDQTEEPEAMEQDEKEEEIPSIWQGKVNMPQVAEFEACARQVGGRQLNAEEWKEVLSPTMWIEGRIPSDRVTNYITQTQYSSSREIVLIQVEAQNRQAEPSLNEGQAQTLLNYLQTRQRYAVVGHNKTKIKDFYLIPLQKVQQIPDWLYVVRVEETKRDADLFLGVLVLQRTKQQQQQQQQQPVSFHYPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2J3</accession>
    <name>A0A367J2J3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002445">
        <property type="protein sequence ID" value="RCH84158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2J3"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="3">
        <location>
            <begin position="204"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37786" checksum="BD98DBF0CE402011" modified="2018-11-07" version="1">MLLSEINSELLTCIAGHLPLKDLKTFSQVCHRFAIIAHSDAVWKEQLYNTYGVTYKLPEESWKDMYERKSEDPKNYRICPHIGYVNGQILKPYAAKYQQVLNWLPKNLNCTTCGSNCKDSGLCLYIWKGNTRNRCKDCAYSFHKAVEGHGILIRMNVLQLYCFDCNRLLGEMRGDASEAYYVNLLLEALTHDSEKGREAMRNRNRCMQERVLYTEQADRYAVLTKERYYFVDRLWMCSWFLRLCDGKLGEGPVANDSLEDPENPGKLNPHSRPRGSFKGGFSIVTPELWDYLIKTYGLKGGTYTSDDINGPEYKELRDAIVEWRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J376</accession>
    <name>A0A367J376_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002440">
        <property type="protein sequence ID" value="RCH84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J376"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="188"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="320" mass="37100" checksum="C0DC901D307A275C" modified="2018-11-07" version="1">MIGPTIPEHLLKKKSIESEIMVSDEEDDRHIGPQIPQDILQKRQQNKAVDSHAAVGPQIPEDLVEQTNEQFDKMNNTCNDYTPELPPDILEQRQKRQKQPTGRRRQPIGPSLPSEFITAREEEEEVIGPSLPKDYNPEEEAKYSAIQAIEERARLSKEAMEKKDEKPKVERPEWMIAPPEIDYLKNANSSRSRQFSNKEVGEIDSSSWTDTPADKERKWKEGTLGKRKAEEPIVYSSQDIERRKAIEEYNMKTRPMSLLEIHRQKKKKSKETPEDVSKRPFDREKDLLAPKRMDSKQKKELLRQSGELNSMFGHGKSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3H2</accession>
    <name>A0A367J3H2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002351">
        <property type="protein sequence ID" value="RCH84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3H2"/>
    <dbReference type="STRING" id="86630.A0A367J3H2"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="5">
        <location>
            <begin position="184"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="430" mass="48562" checksum="DB8E0A45F0C3D004" modified="2018-11-07" version="1">MSIANLFTASVATLYIIEVAILAFATAGAFNIIDIRKLKGQYVALAEILLTSTVTELSLHFIIFKIFLIQVVKFCGGFAYLLSWVMYFVDIATIIGMGKLFYEMLEEKEIAETVIRVIDRKGYKGLQSFMSLELFKSLMNPFWRPPNLVIHPNITYATSEELRDALDNSNQDFDQPRKLMLDVITSNKKSTKPRPVLIHVHGGAWRGGRKDIFYPYEKLLVSENDWIIVNIGYRLAPKSAYPNHLIDVKRAIRWTRQNIASFGGDPDFIVFSGDSAGAHLAAMASLTANDPQYQPGFEQVDTSCRGVVSVNGVLDLTYSSMVNYFSKQVAMHSDVDMDFLHKHSPATAIQQVKDCMPYLVLAGQRDALVNSDVSVKFKKQFDEARHKNPCTLVLFPGGRHISYIAWSPRSLYAARIIQTWCRQLHNGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5D1</accession>
    <name>A0A367J5D1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytoskeletal protein binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SLA1_1</name>
        <name evidence="6" type="ORF">CU097_001394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002173">
        <property type="protein sequence ID" value="RCH85140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5D1"/>
    <dbReference type="STRING" id="86630.A0A367J5D1"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="187" mass="20727" checksum="38955E288EBA2724" modified="2018-11-07" version="1" fragment="single">MNVELYCKALYDYDTDQADELSIKEGEIVRILNKDNADWWLAEKIGQSAASGLVPSNFLETVHVGVVVRDHEAHDDQETSLKRGDKVILLENQGEWTIVEVNGKTGRVPSSCVEEYSNEKSKTFKLAVYGVKQGGIGSILAGGIHRRSSTIKENEEEGPKPPPRPTNDPKNMTIKAMVIHDYSAESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5T2</accession>
    <name>A0A367J5T2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002144">
        <property type="protein sequence ID" value="RCH85255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5T2"/>
    <dbReference type="STRING" id="86630.A0A367J5T2"/>
    <dbReference type="OrthoDB" id="3253553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30328" checksum="55EFD4A19C4BB12D" modified="2018-11-07" version="1">MSYAYDQNPWQEQNGPRFGNAYEDNNTGNYGNAYGQPQMNMPMPGFSATGYNNAWTESNKTEYDPVPPQNVTPHNAYQYSGTPYGNQPQNTGGAYSNIPVETTPTEPNKANNESTSPPTNDKHRSPNQGRFWLSLITLLASIGHLGFAAGARPYSNQDVPFSTSACFYYLWAVAILSIIYSLFHTLLYFYRAVITKYKTNRPMLFAFDLIFAILWGVGLIVEAVKYKCWWGGRFCDFYNVSLFWGFLAFACYIFAVVWDVFDSCRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J786</accession>
    <name>A0A367J786_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosome nuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RRP6</name>
        <name evidence="10" type="ORF">CU097_006761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002060">
        <property type="protein sequence ID" value="RCH85591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J786"/>
    <dbReference type="STRING" id="86630.A0A367J786"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="450"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="601" mass="68810" checksum="4028E5510D38F63B" modified="2018-11-07" version="1">MKEDIPDPSVDFKAYQTSLFKSLVSATAAVNSIPVSDVGYFRTLDRSFAKELDQATSNTLSLANSLLQHCASDAGIESQTDFEDVDDVVRGYGGVIDVCDNLLEKADICLDHLKGKINTDDDILQATPEVAQITQENTGYRILHAKNVVRPQTKFKDPVDNSNNTPFERKIKYKPHAQVPLDMTPVFENGVQKSLPHPYSYEIQHIEYPGRMFEIREPVMYHDFNSTSFTWVDTEEGLEAMMKVLDDAEEIAIDLEHHNYRSYQGFTCLMQVSTRDQDFIIDTLEIRDKLWRLNEYFADPSIVKVLHGAESDIIWLQRDFGLYIVNLFDTYFATKLLEFPHHGLAYLLKKYCNYDTDKKYQLADWRIRPLPQEMLTYARSDTHFLLYIYDHLRNELLTASTHNANLMRSSLQLSNEVALQKYDKEVYDVAEGKGTNGWKYMLSKWKYPMNSQQLAVFKALHHWRDQTARDEDESIRFVLPNHMLFALVERMPTDTSGVIGACNPCPPLVRMNSQAIATTIQKAKMDALLAPPPKEKETKVQTKVTAPGTVQVSLQSPAVQKRKPVREVDPSAFDLKLAKKIRLETCSQLEKQTSALFESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9E0</accession>
    <name>A0A367J9E0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001864">
        <property type="protein sequence ID" value="RCH86449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9E0"/>
    <dbReference type="STRING" id="86630.A0A367J9E0"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="1">
        <location>
            <begin position="65"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="329" mass="37811" checksum="53B7385D6C2E899A" modified="2018-11-07" version="1">MRMLDLKLNVPLLKEKLKDILINSGSTGRFEQEVIVDREWIKNSREGLNVEAWLDDNHLIEPSGISVISDIDDTIKVTDILDGRDAILQNTFFRTAREVPHMNEVYRAWAAEGAHFHYVSNSPWQIYPALMDFINDKQFPKGSMHLRTVSTQDLIMGRPGKHKLTVISKILRDFPNRKFILVGDSGEIDPEIYQQIYNEFPDQIIKIFIHDVSSQRAINADRRLSSASVMDSSYYSAIRKFISRESALLKKKDSSAQLAMDVMATTEIPQEQQQMTDPQVPLVTKLEQFQQRMDRVSSNMREGVFTVFSLASQLMLDPVIAEEFLMNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9Y9</accession>
    <name>A0A367J9Y9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MCM7_1</name>
        <name evidence="12" type="synonym">MCM7</name>
        <name evidence="14" type="ORF">CU097_004959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01001802">
        <property type="protein sequence ID" value="RCH86747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9Y9"/>
    <dbReference type="STRING" id="86630.A0A367J9Y9"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="341"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH86747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="735" mass="82656" checksum="665B728D82B9A145" modified="2018-11-07" version="1">MASLVPVKISVDYSQDKAHLEEFLRNFKESSSDLMETDASPKYMQMLQKIKDRQEKTILIELDDIAAYEDSRARTVANIKRNTKHYIEHASVVIDNILAGMTPSNPDAVHPETVLDVIINQRRTQDRSEIQQDQFPPSLTRRYEVFFKPLSDDTPLAVRQVNGSKIGQLITIRGIVTRVTDVKPMLQVNTYTCDSCGCEIFQEITQRQFNPLTECPSEECKKNNVKGRLHTQTRACKFIAYQEARLQELTDQIPVGHIPRIITLQLYGSACRQLFPGDIAHVSGIYLPMPYTGFRAIRAGLLTDTYLDVQHVHRLKKQYDEIEMTSEDIEKVEELKRDPNAYGRLARSIAPEIYGHDDVKKALLLLLVGGVDKTVGDGMKIRGDINICLMGDPGVAKSQLLKFIAKVAPRGVYTTGKGSSGVGLTAAVMKDPVTDEMVLEGGALVLADNGVCCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARASILAAANPLYGRYNIRLSPTKNINLPAALLSRFDLLYLILDKPSYDMDRLLAEHVTYVHTHNKPPQMDIDAVEPSTIRHYVAHARTKRPVLTPEVGNYVTSAYVALRRQYKLDEAHERQFTYASARTLLGIIRMAQAVARIRLSDFVEPNDVDEALRLIDVSKSTLVEEDDKRYGGYDRSPLSAVYNLVRNLIDAYGFSIPLNTLKQHVVARGYTEAHLEDAIREYTALNVWQVDSHHLTIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA46</accession>
    <name>A0A367JA46_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001811">
        <property type="protein sequence ID" value="RCH86699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA46"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23569" checksum="9B4A1685E0638F12" modified="2018-11-07" version="1">MNASEVRWVSKYVRPVEFVAAHEEIEQPIKKQKTSNGDEVASLYKNIINSTKSPATPSPPPAEKTIWCESCEMTISEADYKRHIQGTAHMVSRKTECEPVDTLTLGGSNVGFRMLTSQGWKYKEGLGKEGQGRRHPIATVFKQDRLCIGHENSGRKVVTHTHQEIERKAIERQRKMEEQKKDPGKEIAKKAKAESRKRVAMLHYLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC58</accession>
    <name>A0A367JC58_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001640">
        <property type="protein sequence ID" value="RCH87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC58"/>
    <dbReference type="STRING" id="86630.A0A367JC58"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="181" mass="21136" checksum="2F2B02B6F4CACF65" modified="2018-11-07" version="1">MTLYYTIVFAILIAEIFTFFLLMLPISTRWKKPVFRWLATSPTIAHASYILKIVFGFIFVLFIDSVNTLRAFYEVVHEEENVTPGTSDFRAQVNQAAKKFYAQRNLYLTGFTMLLLLILNTIKTMTLEYIRLEDECLELRAALSNDPDVKRAVREMDTEPIKDRVTKLEPVEQPEENRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCK0</accession>
    <name>A0A367JCK0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001611">
        <property type="protein sequence ID" value="RCH87668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCK0"/>
    <dbReference type="OrthoDB" id="2285950at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="104" mass="11562" checksum="9736476E6A260935" modified="2018-11-07" version="1">MKAAIQNAQTNQRDFKRKLDELPLNLSSTTTISTRPSVLSSTAASTTPRVSSTIMSPPPNAPSVSLYQRNMTFVLEFKAARIKQAKEFMDWRACMVEGCKIGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDL0</accession>
    <name>A0A367JDL0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001543">
        <property type="protein sequence ID" value="RCH88028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDL0"/>
    <dbReference type="STRING" id="86630.A0A367JDL0"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="19780" checksum="4AC3665E12A181A7" modified="2018-11-07" version="1" fragment="single">VGYIKGYVRRFWQHSEDHRGTPEKPGRVVTLIPYDEWKNIENVEGHDKVTWGVAFKIPSDDVEATRAYLDHREKNGYTVHTVDVYSLENDETPVVKNALVYIATTDNEAYVGPAPLEEMAKQIYETYGPSGWNAEYLLNLAEALREISPGVRDDHVFELEALVKKLIDENSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEU0</accession>
    <name>A0A367JEU0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">F-BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_008212</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001475">
        <property type="protein sequence ID" value="RCH88389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEU0"/>
    <dbReference type="STRING" id="86630.A0A367JEU0"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="742"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="91929" checksum="78410D9D9CBFC505" modified="2018-11-07" version="1">MTTDINSTHFSDNFWESLEKNGITILLERMRGAKQTCERLKNAYEARALLEEEYGKTLLQIAQKQKASSTENGKTKVALDTMQVEFQSIAESHIQLSCHLRDGITTPLAKLINKQKAVRKELQSSIQKLYNNRQLQVHFVRRAHKRHNQEIEKANILVEGKSTEEEKQAAFKTAQATVEKLKSVYDEGLNDLTKIVEEWNNEWKNTCDTFERLEQERIQFFKTNISNYTNLMVGCLENEIQAYERVNVKVEDVDVMQDLTDFVNENRSTHIVPSPMDYIKLHAYQEVNLGKEEETKSTFHNTIDHEEHSDTEDHELVKNVEEKKSEVQPVPDKIVVEHTTVTTTSIDSTVALVEQEPDTDSPKILMVGKMEVYGSDDSDDDEEYEYVTETESEEENEIKEEKKENVVSQEKEDTMYSKPLSQSTEKDQASPVVIKAKEEKNSEPIEVGQGNQSTSDEKISKLAATYRKQAADAKLKRDESFSSILLKKGLNTTRRRVSFLNDERPSTEQQEDNKPLYKTSSIDAVKRTISSDSTETQDTTGIEQDAAARELDNMLRELDTTHRNHYRQPNIRPTASASSPSLLQDRWRGSYFDSQSSRRMSTADNSVGNISQRISPSRNSNNTSYSSSTMSSNNMGDLYDPFNSLSSSSKSGANGLNDVMPTKSMSTSNTPTAQMIHERMLRNGNKLGHYRRRSVNNADTISSGSSASLASVRSREGFVQNFYNLKKNNNGMSTIPPENREQFIDFAIALYDYEGADEGEISFKQGDLLGIISKGDDEQGWWEASLLDKVSAKIIQTGLIPSNFIETAFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF92</accession>
    <name>A0A367JF92_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001432">
        <property type="protein sequence ID" value="RCH88632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF92"/>
    <dbReference type="OrthoDB" id="2270203at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="164" mass="18740" checksum="413A3E0A2A7C7638" modified="2018-11-07" version="1">MFKGLGEFAGQCTAPKMYTDKLKLALMAKLHLNFFTKKTGKDDIFVPFLLIMGFECQLLMLRLAQAKLYYLEEVGRSSFPISKKEIDEVVIKEMVNLLTFTRDRALHLRQQMLDSRLSPVVVNIDWCTDVVWPSGKKVPAVVAEEDGEGDDDEDEDNEDDNEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG62</accession>
    <name>A0A367JG62_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Catalase</fullName>
            <ecNumber evidence="3 10">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_009361</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10"/>
    <dbReference type="EMBL" id="PJQL01001392">
        <property type="protein sequence ID" value="RCH88859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG62"/>
    <dbReference type="STRING" id="86630.A0A367JG62"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016759804" description="Catalase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="48"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="cross-link" description="3'-histidyl-3-tyrosine (His-Tyr)" evidence="13">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH88859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="732" mass="83106" checksum="781C29F02E7FD23B" modified="2018-11-07" version="1">MKKPAWILSLILLSCHLSLGADNDNNNNQDSPVTNINAHVIDAGTQETTQFGVKINNTDSLQMGDRGPTLLEDFMLREKIMHFDHERIPERAVHARGVAVHGYFQSYKDWSNLTAARLLRDTSIKTPVFVRFSTVLGSRGSADCVRDVRGFSTRFYTQEGNWDLVANAIAPFFIQDAIKFPDLIHAGKPEQNTEVPQAATAHNTAYDFFGQHTETIHTVMWALSGRGTPRSFRQVEGFGVHTFRFINEHGKTVLVKFHWKPLQGLSNLEWDEAQKINGKDTDFHRNDLYTAIQRGDYPEYELGVQIVNEEDQDKFDFDLLDATKIIPESLVPVTILGKMTLNRIPDNFFSETEQVTYHPGHVVRGVTFTDDPLLQGRLFSYLDTQINRMGSANYLQLPINRPLVPVHNNQRDGFMQFNVYHGPVAYYPNALQNNTPEVVSPREGGYLEYPEKISGRKQRGKHGKFSDHFSQAQLFYNSLTTHEQQQVVNNFRFELGKCTSMLVRENFIKVLNRVDNNLARRVARGIGVHEPEPVVENHNQTTINLSIDNYKRPNNIKAKKVAILTGPGISTSEVEQMRDYLTKEHAYVDVVGIKLGESDDGLNITETYLTTSSVLYDAIYIPSGSNSTFDFLTKPHPEFPYDEPSVFALDAFRHGKPIAVSGNGIELLKKAHVRHFDSNEQAAHYGVYISTDMSQLESQFKKGIIIQRFWNRMPLDPDAKESPTRFNVTIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGK8</accession>
    <name>A0A367JGK8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001361">
        <property type="protein sequence ID" value="RCH89026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGK8"/>
    <dbReference type="STRING" id="86630.A0A367JGK8"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="524"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="564"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="600" mass="67812" checksum="97B8F751EEE6C915" modified="2018-11-07" version="1">MSKDKERLHSFLFRHVPSQVSNKQKLCYRHRPDLVKNRGPDEFSAQQVQEEIERLPTADKEAISHIWSLFAAAPSDQRILILKGLISTCCMPQLSFLFNATQPLLRIDFVSVFPKEITLAIFSHLDAKSLCHAAQVSTKWKEIADDDQLWHRMCEQHIDKKCEKCGWGLPLLDKKTRSAYKRKRMMNDTSTTSPIQIACGPAPTIGSPQDSCNIKRQRIETVNTQPLISPPPRRRPWKDVYSERLIVERNWRNNNHSLLTLNGHTDGVMCVQFCEIAKLVITGSLDKTVRVWHLETGELIKILTGHSRGVRALQFDDAKLVTGAMDNTLKIWNYHTGQCIRTLEGHTGGVLSLHFDSRILASGSTDHTIRVWNFDIGECCTLVGHSEWVNSVRICQQGQMLISSSDDATIRLWDLHSRSCIQVYRGHVGQVQVALPSPHGFKHRLKSKTSLPERSTEQQQVFVQRTSCSNTEVIRPTPATYPNNAEPFKPSQSTASDLPIIISSSLDNTIKIWDLHSGQCLRTLFGHIQGIWGLDFDKLHIVSGSHDKTLRIWDTETGRCLYALEGHSSPVTAVALSDTKIISAADNGEIKIWDFGRIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHK6</accession>
    <name>A0A367JHK6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sm-like protein lsm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM7_2</name>
        <name evidence="11" type="ORF">CU097_009764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001290">
        <property type="protein sequence ID" value="RCH89424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHK6"/>
    <dbReference type="STRING" id="86630.A0A367JHK6"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="133" mass="14605" checksum="7D75AAE2FBBADFBC" modified="2018-11-07" version="1">MSERGGRGQYSNRGGDRGGRGGGRGGGRGGRGGYHNASQEKPKKESILDLSKYMEKKIRVRFNGGREVVGTLMGYDPLLNLVLDHTVEYQRDLETGYVTENTRELGLSVLRGTAIILISPFDGMEEIENPFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHS4</accession>
    <name>A0A367JHS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GCN1_1</name>
        <name evidence="6" type="ORF">CU097_000082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001281">
        <property type="protein sequence ID" value="RCH89477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHS4"/>
    <dbReference type="STRING" id="86630.A0A367JHS4"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="235"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="525"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="885"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH89477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1276" mass="140039" checksum="BDD43CBBAD630B57" modified="2018-11-07" version="1" fragment="single">NESNAQLAKGQWEENAMDVDENYLDQLLAYIVSDNDYVRQAASRAMAEAVEIYPDTVGATLQAIYDRYKILAAPLTPEYDEYGMVIPETLDRPDPWKARVGLALTLKAMAPFMQSQNAPNFCKFLIVGQALGDRHELVRSRMLEAGMAVINAYGKESVAEFLTTFESYLNSKTDNSDVEDHIRQAVVILYGGAASHLSPEDEKVNTAVEKLIDTLDTPSETVQSAVADCLPPLIKMCKDEVPRLIKSLLNKLFKGEKYAQRRGAAYGLAGVVKGRGITALKECNVMNALKDAAESKRSYEQRQGAMFAFETLSATLGRLFEPYIIQIIPLLLACSSDANADVREATSDAARVIMSKISGHCVKLILPSILEGLDDRQWRTKKASVELLGSMAYCAPKQLSVSLPNIIPRISEVLADTHAQVRASANRSLQLFGEVISNPEIQALVPVLLKALSDPNNQTGPALTSLLQTSFVHYIDPPSLALLMPILERGLRERTTEVKTKSAQIVGNMASLTDQKDLVPYLPVILPGLHQVLVDPVPAARGTAAKALGALVEKLGEENFPGLVLDLLDTLKSESGGVDRQGAAQGLSEVLAGLGLERLDGLLPEIISNAESPRSYVREGFVSLLIYLPATFGSRFQPYLGRIIPPILSGLADESEYVREASLRAGRMIVTNYATKAVDLLLPELEKGLFDTKWRIRQSSVQLVGELLFRITGIHTKNNDMALGNVVELNEDDVDANYDEDYGATENKKKQLVEVLGKERRDRILAALYIVRQDSSGMVRQASLMVWKSLVSNTPRTLKDIMVVMLHMIIKLLSSENYEQRAVAGRTLSELVQKLGESILPEILPVLEEGIRSDDEATRLGVTVAYSEVMTSADKVQVNDFAEQIVPVIKHALCDPSDEVREAAAQAFDTLNQCIGAKAIDDILPSLLNKLQSSDESSGYALSALKEIMSVRSHAVFPVLIPTLITVPITAFNARALASLVTVAGPALNKRLTAILDALMESRMVTDDEETKEALKATTEALLLSIDEEDGLYTLTVALMEYCRNDNPNKRAIACDITGEFFNVTELDCSAYVPDWIHLLLLLLDDPIEKVIESAWHALTAVTKSVPKEEYEELVIPTRRALVNIGVPGCDLRGFCLPKGISCILPIFLQGLMYGSTEVREQSALAIGDLIDRTSVVALKPFVTQITGPLIRILGDRYPAEVKAAILQTLRLMLNKVPMHLKLFLPQLQRTFVKSYSDSDNEQVRQLAASALRVLSTLQPKIDPTVAEILEKEPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIM2</accession>
    <name>A0A367JIM2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_006896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001237">
        <property type="protein sequence ID" value="RCH89719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIM2"/>
    <dbReference type="STRING" id="86630.A0A367JIM2"/>
    <dbReference type="OrthoDB" id="2215782at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016868523" evidence="7">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH89719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="372" mass="40297" checksum="D1502EBA5182BED8" modified="2018-11-07" version="1">MGVMKRLVQLCLIVHSVTAFSLSWFQFKIPVQVGGTAFVSWSDYDYSLPVTIKLAVQNPDGSLSGLYTWDNLPTNVLPTAMLNIPESATPGINYYFVGYQNISQYATLGPFILYSQSMIEPTTSYIVSGATASIGPTASASRNTRSSSTSKSTGTPQETFSVEPHGSSLSTGAIAGIAVGGAVVVIGAIAALILLLRRKKKNNKSTDNQDNNNNNNNNQQQYMSMPVPQKDEFSGPDSTAIQMNQQPFMTGPEGQYTSSFLPPYSGPQQQMQQTHSYYSQQRTSNIESTHDYTTNTEASLSPQMTTSTAPYNADPLTHGKTMLPSETSSGGLTVNDPTLLLLSSMSAPTYQKPETAYQKPDEVHPNNKPHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJQ2</accession>
    <name>A0A367JJQ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein vta1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_011928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001166">
        <property type="protein sequence ID" value="RCH90170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJQ2"/>
    <dbReference type="STRING" id="86630.A0A367JJQ2"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH90170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31679" checksum="57BED8A9C4320A65" modified="2018-11-07" version="1">MEIPPELKYITPYIQRGQELLSREPVVAYYAQYYAAKLAISRGPRTKETNEYLSHLLESLETQKKSLGDNEAVTNDLVGYAHIENFALKIFLNADNEDRAGKASKKTAKTFLAASVFLELLKTFGDIDSEVEAKIKYAKWKATDIMKALREGRQPTAGPPIDESEQQEQVPSISEFPSPPSNFTAPLPSANSQLPDVPTAPAAPVVPAVTAPPPVPAAAPAPAPIPSSLPVQSPVSTMTVAEVSSVDISHAQKCAKWAISALNFEDIITARQMFLDALNAIGFNEKNDFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKP3</accession>
    <name>A0A367JKP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dipeptidyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_011249</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001121">
        <property type="protein sequence ID" value="RCH90439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKP3"/>
    <dbReference type="STRING" id="86630.A0A367JKP3"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="14">
        <location>
            <begin position="166"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="13">
        <location>
            <begin position="654"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH90439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="100507" checksum="2B31913D6335BC06" modified="2018-11-07" version="1">MPSESYFDEESVSDSQRLLSTYSQSTEDYETDEKYLIKEKNLRKKNFNWTCLGFLLILVIVVLLWATSITQLLVEFSTSVNTEDIPGTESKRLEFDDVFNSSFTVKRASLVWVENDPRDGIYTFRDPISNDILIESIEDRKSEVFVEAKDLRIKDRLLDVHSFDLSHDSKYLLLRTNVTKQWRHSYLSSIYIYRRSDKALFPLTNASTVDTEPKIAYAAWSPTGHKVAYVMNNDIYVTDLKNHYRITFDGSKTVFNGVPDWVYEGIPDSVAAKSSFLMIHLEEVFATNFALWWSPDSTHIAFLKLDETEVPEYHLQLYTASRSNYPKETNIKYPKAGSPNPIVSLHVHSFLTNGTVDVTTSSEDNTILHANQYKDFAKNDRLIVDVAWCTSAHSHLLFKQTNRVQDHQFTNLVVLDPLDIGNSTVHKIQEYKPKDKGWIDISQSMVYLPSNKSDRVQFLDIADNEEGFSHLAIVTVKDNGHTQISWLTSGEWEVVSGSVEVDPVRQLVHFISTERSPYERHLYSISLKEEFPASSKVCITCPNSPDEHAYYSVSFSPKSGYYILNYEGPGIPNTVVKKVNDTSFKAVLEDNLDLRLLLRDYDLPKMHMKTITSGDVEMTAMEVVPPDFDASKKYPVLFHVYGGPGSQLVSYKFELSWQTFVASQLGFIVVTVDGRGTGFRGRNYRVGVRGRLGELEVIDQVNAGRHWASLDYVDEYRMAIWGWSYGGYMTTRVLEANSGVFSTGMAVAPVTDWRFYDSVYTERYMLTPKLNPQGYNRSAVNNMTGFKNAKYLLVHGTGDDNVHFQHSATLVDKLTLADIHNYRVQFFTDSDHAINYHNANRNVYYILTEFLLESFGGHQYKHIYSETNGKFSGPLPEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM38</accession>
    <name>A0A367JM38_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_004440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001040">
        <property type="protein sequence ID" value="RCH90965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM38"/>
    <dbReference type="STRING" id="86630.A0A367JM38"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="564" mass="61583" checksum="A85BD58B19865EB1" modified="2018-11-07" version="1">MAQETSPLLSQDSPNYRSNEDNNREETITIITSNSSSSSNSNTPTLPSSEDETLKKRLNNASLYTILFGLWTAVVLSSLDSSIVASIYPQIGTEFKRSNEIVWIATSYMLSYTALQPLYGRISDVFGRKSAVLFASVVFFIGSLLCGTATSLWYLVIARAIAGIGGGGINCMTTVICADLVPLRERGKFQAYGNIAYAVGSVVGAPLGGLLTDTFGWRFCFYINLPFLLVTLYVSSNLLTNYNLDENQQTERFSDKLKKIDYLGATTIVLAVIAFVIATSLGGNIRPWSDSLVVGCIIASIILSVIFCFIEAKVALNPIMPWKIISSRTPLASSMTNFWTLMCGMAMMYLNPLYFQAILGYSPSTTGLFSLSRAAAAPFGSVMAGVYMSRTGEYKKLTIAAACLLVISMIAYSTWSVNTPQILYILYPITDGLALGSILVLVLIAMHSSVEATEMATITSMSYLFRSIGGVFGISATSAIFQGVVKNILVEKIHGPNAEMYIEIARKSMTEVRDLLPADIVTIVIDSYQVAYRYTCYACICIAFLALFSSLFIERYDLATKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM45</accession>
    <name>A0A367JM45_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SPT15</name>
        <name evidence="6" type="ORF">CU097_012970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001036">
        <property type="protein sequence ID" value="RCH90998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM45"/>
    <dbReference type="STRING" id="86630.A0A367JM45"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7601" checksum="5DA8918E3FE519AD" modified="2018-11-07" version="1" fragment="single">LAYSHGHFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKVREEIYQAFQAIYPVLTEFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMB1</accession>
    <name>A0A367JMB1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DGOA1_2</name>
        <name evidence="8" type="synonym">DGOA1_1</name>
        <name evidence="8" type="ORF">CU097_008826</name>
        <name evidence="9" type="ORF">CU097_010995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001825">
        <property type="protein sequence ID" value="RCH86638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01001025">
        <property type="protein sequence ID" value="RCH91073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMB1"/>
    <dbReference type="STRING" id="86630.A0A367JMB1"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="7">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="438" mass="49753" checksum="6DFEBB3C30150648" modified="2018-11-07" version="1">MVQALNDCVITRYEIRDIRFPTSKFLDGSDAMNKDPDYSAAYVIFYTDSKLEGHGMTFTCGRGNDVVCAAIEQLALKFVNRKLSDLVSDMRATHRICTGDSQLRWIGPEKGVIHLATGAVINAIWDLWGKAVNKPVWKLVVDMTPEEFVQCIDFRYITDVITPEEAIKMLRELEPTKAQREAEMREHGYPSYTTSAGWLGYSDEKVRRLIREAKAQGFTHFKQKVGGDKEADIRRAAIIREEIGDDGVLMMDANQVWDVQEAIDWMQDLLQFRPLFIEEPTSPDDVLGHAAIRKALYPRTAVATGEHIQNRIIFKQLFQAQAIDYCQIDSCRVAGVNEILAILLMAKKFNIPVCPHAGGVGLCEYVQHLSFIDYICVTGTTSNRVLEYVDHLHEHFIHPVVMKNSKYTTPLAPGYSIEMKRQSIEDYTFPNGKIHKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMY0</accession>
    <name>A0A367JMY0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000991">
        <property type="protein sequence ID" value="RCH91287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMY0"/>
    <dbReference type="STRING" id="86630.A0A367JMY0"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="242" mass="27163" checksum="74071A7EBD01D336" modified="2018-11-07" version="1">MTTIQRKEEIVYNLTTVRNNMQKILNEQQREACLVAVSKYKPIEDLMYAYEAGQRHFGENYVQELVDKSQKLPADIQWHFIGHLQSNKCKTVAAIPNLYVVETVDSIKKADTLDKACKAVGRKEPLRVFVQVNTSEEDAKSGVDPSSAVNVCKHIIEQCTNLKLQGLMTIGMFGRDPSVENPDFKCLVECKQKVENELSVKGLELSMGMSSDYEMALKMGATNVRVGTTIFGGRPPKTEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN74</accession>
    <name>A0A367JN74_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_010952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000986">
        <property type="protein sequence ID" value="RCH91319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN74"/>
    <dbReference type="STRING" id="86630.A0A367JN74"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="480" mass="53077" checksum="F485FAC25A372231" modified="2018-11-07" version="1">MKLLKGSALLYSVACFASLGQFLFGYDQGVMSGILVNNRWLELFGHPSSTLQGLIIAIFELGAWFTSYPTSWFMDRFGRRWTILIGAAIFIVGGSVQTGSSNLAGILLGRLIAGFGIGFLSTVLPVYTAELSRAHNRGKVTVLGMSINMFGYMASEFIDYGFSFVESDWSFRGPLLLQVVFALILAVGTLALPESPRYLLSKQKDDLALETLSDMYGKPADNPQVLQEYEEIKTTLELEAKLGEPTWGEMFTLYTRRSFIAIAVQALGQLSGINIVTYYAPKMYEAVLGPGNKTILFAGFTALVYFCGALIAAVLVDKVGRRPLFMSGSFFMIIWLVLMAVFNKIDLGMTSAILVIVFTMIYVGTFGITWACVDWLYPAEIFPFRTRAKGMSLAVSSNWLSNFAVGLWTPPLLDRIGWATYIFYAAWNVVALFVVYMWFVETKGKSLEEIDAIFEDGAGDVPPELAINNEKKGVSDENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNC0</accession>
    <name>A0A367JNC0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_001537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000970">
        <property type="protein sequence ID" value="RCH91433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNC0"/>
    <dbReference type="STRING" id="86630.A0A367JNC0"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH91433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="157" mass="18217" checksum="0743CB6C1136DC3A" modified="2018-11-07" version="1" fragment="single">YGRRHFGTFSEKRYHEIKRLMTAPLFVNDLLNSRYSDLCSPSNWTNIKQEFQRDFCSLLRMSIQSPLYTSVYVGTTALPVIMKLYKVMIMNKAEWSAQGELPVEIPLEEELRFHSVFACPVSKEQATDNNPPMMMPCGHVICKESLTRLARSSRIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNQ9</accession>
    <name>A0A367JNQ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000951">
        <property type="protein sequence ID" value="RCH91567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNQ9"/>
    <dbReference type="STRING" id="86630.A0A367JNQ9"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="393" mass="45409" checksum="B07EA00F4C18DEAB" modified="2018-11-07" version="1" fragment="single">MSNNKDSKKKKANGSKDCSKLPMPYEDLQSLQVAFYEINSWIEKSKSLLRKTTAELEKASRHLQVKPKPDPTIAIEQLLDQHPLLDSSSINDMKWVLSFQPDNLLRIDTNITSVEQLIEAVHKIRRLQQGKDCMQEDVQEQSLELYSSPCTPSTSSTASSSYYQAAEYWSNASLKNPHFAIDGYKHCCMNLDNLLKSMIPNPLQCILQVSWNCLHPKFASDWDSFWNRSTDPKLNRLCTDSALSRVFLHIMRHDRALCPNAPDLAGYYYDRAREELMEYFDAPASCALIEAIINLSMSCLISKRYSKTQIYLDLGYRKWLELGASRSQYRMDIMMRKRYLKLGLALRYSDYLNNYDSGEPCIIDDNDHNVDYNEINELNDKILKGIKCKQDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPG9</accession>
    <name>A0A367JPG9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000916">
        <property type="protein sequence ID" value="RCH91818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPG9"/>
    <dbReference type="STRING" id="86630.A0A367JPG9"/>
    <dbReference type="OrthoDB" id="2438604at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016900206" description="Tyr recombinase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16600" checksum="BD7212AB99DC9E53" modified="2018-11-07" version="1">MAKTAWILAMVGFLRPSYLARMDLEKCSVSEDKVLHLCVVAPNETRQGSRITKTIIIHPHPDLLLCPVTAYSAYVSWIASHIRRTMTHVGKPEDAPVPKARALDATLAAQAGILSIVCWISIIMGGRSDANDFGSSTTSERVPLSHSEFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ04</accession>
    <name>A0A367JQ04_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-protein Rab-11A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_002866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000886">
        <property type="protein sequence ID" value="RCH92030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ04"/>
    <dbReference type="STRING" id="86630.A0A367JQ04"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25892" checksum="E38501E007465F0B" modified="2018-11-07" version="1">MSYSEDTYDYLFKIIIIGDSGVGKSNLLLRYTSNEFLQDSRSTIGVEFATKTINIDNHVIKAQLWDTSGQERYKAITSAFYRGAVGALLVYDITRKSSFNHIAQWLEELNEHIEDSIPLVLVGNKIDLSDTSRAVSTEEAKNYASKSKMMFFEASAYDTTNVTLAFETMFNQIYKELSKSKLLKRNTSRDVHALPVNTVNTIRLRPPSVYNNNNNLTHSKRSENKCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS14</accession>
    <name>A0A367JS14_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000784">
        <property type="protein sequence ID" value="RCH92752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS14"/>
    <dbReference type="STRING" id="86630.A0A367JS14"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="258"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="625"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="866" mass="100570" checksum="E190FB5A54F9037F" modified="2018-11-07" version="1">MRQHVASDFRLKENKHPFVFENEKGHVLVIAFITSSIVRVQYLTELEREQQIKEADCMADSVDVKLSNTCVDGQLLTDTLELKTLDLRLVITLQPAFQLKWYPLEQQDASEFPFAEDLLYRAYAYDKATDDKWHYQRKYDSNLYYGLGERTGSFDLSGRRFKLERLDCMGYDAETQDPLYKFCPFYICLSRKSRHAYGVHYNNFSKAEINFGQELDAMWKTYTYYHSESGPLDYYMIFGPKVSSVVQKYSYIIGKPRHLPPRYSFGYLASSMGYAESDEAQKKIEEFVENCKKYDIPCDGMHLSSGYTVNADGDRCVFTWNHKRFPNPEELSKKLKEAGIRIFANVKPWLLQHCHPDFESVKADKGFVWDTDEDQPSTVMQWRAGPNTIGKASYIDFSSESGYNYWKSRLKTELLEKGYLLWLDNNEFTTADDGDTYANQVAPYSFSGMYGSRITGPILPRERSETIKVGTPLQTLLMIQASYEALREHDPVQRPFLITRSATPYAQQLVSQTWSGDNMTSWKTIKYNIPMGLGAGLSGMPYGYGHDIGGFAGPQPDPEMLVRWVQQGIFWPRFCVHSWNSDNTITELWMFPEMLPVIRSSLQFRYRLIPYLYTLYVRYAYYEQQPLIRPVLYEHQHDINTYDQQFEFMVGPSLLVAPIYEPDQTHRQVYLPSNTSWYHFQTGTYYKTDPNAGQWVKVPAPLTDEAAPLFVKEGSLICFGKAMNNVHGSIDDDRRVQIFPRRFGHMDDVHYTRETLILYEDDGETLYHETGAAYAEIHIWMEERETEIHVGMEIVKDGYFPYYDTVWVTCPIKSETRKLIFEVPDEESNAPQTLASRQLPCFVDDDNNLAYFGIRLPKSRSNACET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSN4</accession>
    <name>A0A367JSN4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000763">
        <property type="protein sequence ID" value="RCH92916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSN4"/>
    <dbReference type="OrthoDB" id="2239868at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="98" mass="11490" checksum="86D4CC3E2D759C05" modified="2018-11-07" version="1" fragment="single">MYRATLKPFDDDLYQPTTIFTLCDLPNNEATKVVTNNTKFEMIDFDDVFIKFELIYSQKKKPETNDESDASKTLKLLMEACQRYKKEKGEQADIMEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT03</accession>
    <name>A0A367JT03_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000745">
        <property type="protein sequence ID" value="RCH93073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT03"/>
    <dbReference type="STRING" id="86630.A0A367JT03"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19863" checksum="82B76A26A0063CD6" modified="2018-11-07" version="1">MSKSVNLLQRLALTYKASRFPWKKHALVGYDLSGNEYWDCPNPLGGRMKRWVQMKNVPRGNLTIFEENQLPVQWQAWLRHTRDYPPTIEELIQDEKRKSIVKERARALEQEWEQRKLQLQQEAEKEKQLLEESSRKEKDKSEEPKSTEPAGQGDTFTPGEWNPTVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTK2</accession>
    <name>A0A367JTK2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000718">
        <property type="protein sequence ID" value="RCH93273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTK2"/>
    <dbReference type="OrthoDB" id="5591056at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="888" mass="102151" checksum="2DB391B47726E820" modified="2018-11-07" version="1" fragment="single">HSLALKKTAETYSIMHDNMEDKSEDSFLSFSTTTTARKRTSRESSQNDSQGKKANSEQLRSSDYWFESDYDFFQSLLSGESSKTIGLQKNLASNTFASTSGAAATFSGTAMPTLETVAPSSATGVSNASASVSASNGRIMSIKTTVKDIWKAPYVKPLHDLVDLTNKVVTHTFALSKFIFLKEITSDANFDLGNHINKNFFVEVFLSLLLRQSRDGSVTGKSKLTDAVQNYRKLIGKHKDHYFQHAKYTPAKLTNAQQIALYECVKIQTAYVNNIRAHFGNRLLMVLNKLFKKTEKTENLRQKMKTQGYSDDDINKAIREQITTPCTLFKLSISKGVIHNDTQLDNESRLKLEDFLSTYPKSYRFEKDSIYYDVVSRPQNHFKAFFKLASICEFLKSDCFVCFPLRTSFIPTYMTIDSKIVNFHILKNKKVSSDKLDIWNQVVYLQKKVLRRQGTISFEGTIQTDGVGVSVVKQNFPTSRKQAGNKRRKDIDTDENKVEYIEKLTSSQHAEIKGKCVLMDPNRRDLFYCMKETSSTERKQILRYTQSSRSKLSRHFRKLQKNLKPEDVRFAEEMTSKKKSKSVDLPSYIGYIKVRAEYEDVLTEYYGNETKTNVRNFYPDTINDFFITKTHDLYWGRLFVARFTGTFPKNNTDNEDELFKLQNFITHLQILLNQAHVKKRLPKTTITHISRFAEEALIWSFGCQDQAAIIQKLKVVKNFTSSQLQTLNLLPFRKMRFSSKLYSRQNEESLVKGLKEKFGRINKGLISMLQKNDLKVLLIDEFKTSSVCPDCEGKLEKFKRVTNPRPHKRQKHPTVICNGLLRCSNHQPVKLWNRDQAAVCNFKKILVELRKSEKRPDCLARSNATTSFKRRREDSSSSDYKKAKILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTN4</accession>
    <name>A0A367JTN4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000748">
        <property type="protein sequence ID" value="RCH93051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTN4"/>
    <dbReference type="STRING" id="86630.A0A367JTN4"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="185" mass="21225" checksum="845CAA6A20F104B1" modified="2018-11-07" version="1">MLLSSNKRSCCLFVPIKTGVYLITTIGLLNKLSGFYGLISLEYSDPFAVLAHVYSLIALFIFSLGLYGINNNHHSLIRSYAIFYWIDFVIGSLMTVYFAFQWFIFTDHSLPEIADDVDKTRQHDDIFKTESIVSITILCVIRMIQIYFACIITEYYLSLNKIKYSKITAVVDEEMSMTETKQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTS3</accession>
    <name>A0A367JTS3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000708">
        <property type="protein sequence ID" value="RCH93364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTS3"/>
    <dbReference type="STRING" id="86630.A0A367JTS3"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="27211" checksum="EB30FBFFA91BD624" modified="2018-11-07" version="1">MTSKQPIHSVLFDNQNEYYAQPTSGDNLQFYSSSYGDQYSTNYYASPPAGDMRSTNYEFSNSGSFWSAFGTGGYADEPPLLEELGLNFEHIKTKSLTVLNPFRTVPSTIMDDTDLAGPLLFIFLFGTFLLLSRKAHFGYIYGVGVLGVISIYLILNLMSENGIDGSRTASVLGYCLLPMVMLSGLSVFLKLDTIVGTFLTIISILWCTYSSSGMFVSVLHMNEQRFLVAYPVGLFYACFALMTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUF0</accession>
    <name>A0A367JUF0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000685">
        <property type="protein sequence ID" value="RCH93538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUF0"/>
    <dbReference type="STRING" id="86630.A0A367JUF0"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF46">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22998" checksum="246C989C781F70FC" modified="2018-11-07" version="1">MLTDRHCREFKEKGYTILLDALDKQQVELLHNEADELANYLMSEQVDLVKDLGCVLEPWTCGYIDTPKTKEYKVNKQEYAKIRDSIYPSDHATVSSLLFGTYAIWASQLLNSKYIYLLNEQYIVKPPLSSSYSQFAWHRDSDYYHDTSIKNQVTIACWTALDDVNRLNGTVIVEDDHKGIYASILFSADLGQDKITSTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUK7</accession>
    <name>A0A367JUK7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000680">
        <property type="protein sequence ID" value="RCH93575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUK7"/>
    <dbReference type="OrthoDB" id="2286105at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="85" mass="9788" checksum="24F68A8F20F467B4" modified="2018-11-07" version="1">MRIAMSETQVEERADEDPAFTFNKLLFLANDRTMPQEMKYNVVSEDVPPVPEDNDINKTFSYKSYDLENIKKSIHLMQEEGGSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVE4</accession>
    <name>A0A367JVE4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_011038</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000645">
        <property type="protein sequence ID" value="RCH93875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVE4"/>
    <dbReference type="STRING" id="86630.A0A367JVE4"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="10">
        <location>
            <begin position="798"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1199" mass="137599" checksum="1B550F3CA1BEECB6" modified="2018-11-07" version="1">MAAEAEFPRIICRVKALYAFNSKEKSSLSFEKDEYIDVLSQLDTGWWDGLCKGSRGWFPSNFVKIVDPEEGQEEEQIQPRQQESDGEEERAIEILQNMNKQNNRISLFVTSNSRPLSLALEQPPVNIAQPMNTDKALNKKLPEGWTLQIADDGVTEFYYNQHTGGLRWNHPSLLDSDEEEEELSSTEGKNEEQHTYNEYHDFGKKEQQQQLQQLQQLQIQQQQQQQQQQQQQQQQQQQYKSPITTNHTNLLSYWTKRTTPQGKVYYANSITQETTWDYGDIDQATGLLKQSKRSIEQQSKRVDPSLTMIGEDLEKEEEEGDAEGKPISWKSIAIDIAQSVQSLHKAIVAGDNPVTFKQKITSVVDAVRLMLYSSRSMDKDAPHLQDAEVKEPHRNVLASLAKLILSAKALNESNMNHNNGKVQRDAADVLNAVRKFVLVCQNKNVPIRPVNPRLLFNTADNNISNNGTQQEYLEDTEEEGKRKSNNSPAITKAKYPLNQDLIVSLQTHAKQIVGSTDALCKASSYIYQVNQYQIKKENEQVDTEKKEESDEEEITDEKRYVLEERAKSNVILLFQNLSSQIGNYLAILNDIDISHIDPSQLQSLPSFRNNKQRLYNSVGLLFSAVQTLTNSQLDLMTSINRIEETVGMVENAIEEIFSNVVQMVGERKIWMMRNGEHAGAIVPTEPNSPVSNYFDIGGKQRPSRGSLTTDDESSEATTPIITRFYNRQNSQGIVSSHRPSISQSTSNLTRPSPGPQSMTNSKALKRQFSFGHGNTHDEMSQLWFLQYDYAEGDIVFSADKSVKGGTIRALVERLTLHDEIDMSFIANFLLTYRSFCTTEEFVELLQERYNLAPPEELTPDELEIWTDKKQKLVRLRVFNVMKNWLENYYNEEDEFILNKLQFFANTVICDSSSFSAEQLNRLIRKRREQDGVLKKLIPNNTNGPMPIVPKNLNHIRLLDTDPLELARQLTIMDFKLYSSIRPIECLGKAWSRDDDTAVNVKQSIDYCNKLTAWVTGSILNYKEAKKRVVVIKYWAQVANRCMELQNYNTCMAILSAFDNSAIGRLKKTWEQVSSRTTQSLNAIRKVMGSNRNFQEYREMIHSVNPPCIPFLGIYLQDLTFIEDGNPDYLKKSSNLINFAKQQKSAEVIREIKQFQSPPYIFQYVPEIQDFIKHHLDHSKDVDFLYERSLELEPRTQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW58</accession>
    <name>A0A367JW58_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000608">
        <property type="protein sequence ID" value="RCH94176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW58"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="366" mass="41855" checksum="586FC07C6B3CC966" modified="2018-11-07" version="1">MATVVKEEKDEYYDVDDGGSIGGDSGFSTGEEDKHDGSKATAAVATVQEVTTEQSEQLEDVVEVSRDVRDEQVSVVVQEEMILVDDEEEQKKNFFTRVASIPIIQDSYLGAHNIVRQHTIGQKALDYAETKIQTILVSAQSIDNKPLGTIFSHANDLGNRSLDLLERQFPVINSPTQEIIQPIKGRLDQAVSLWKEKGDRASMDRITNQFERLLDYYLPAEQEEKVTIQEHGVQRLVKVINILSSRITQKVMNKVEASKEEERRIRAVIKTWIIEQAKSMIEKRPFLKEKIDIGSEQVQTLYNFTQTELDKVRQELNKQNLSHMERVRSIWTLSRNDIILPLFEKSSSLFYSKRQDQQQSKMAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWN7</accession>
    <name>A0A367JWN7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000587">
        <property type="protein sequence ID" value="RCH94353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWN7"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="13480" checksum="8009C21B5B5961BE" modified="2018-11-07" version="1">MDSVKEQKCVIGNKKERNRQSQAAFRFRRKKYIKGLEESIMRMHISTKRLNQELERTVHRAENAERQCLALHEELYSLRKLTNRLFEENKQLTQLLFNDGQSFVYESQYGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX25</accession>
    <name>A0A367JX25_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PHB1_4</name>
        <name evidence="4" type="ORF">CU097_011883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000573">
        <property type="protein sequence ID" value="RCH94486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX25"/>
    <dbReference type="STRING" id="86630.A0A367JX25"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="276" mass="30325" checksum="9F62392A3949C5A6" modified="2018-11-07" version="1">MAAILEKIAKLAIPAGLVVGGIQSSMYDVQGGYRAVIFDRIQGVKPNSVGEGTHFLVPWLQRAVLFDVRTKPRNISTTTGSKDMQMVSLTLRVLHRPELKNLSTIYQNLGEDYDERVLPSIGNEVLKSIVAQFDASELITQREVVSAKIREELYKRAREFNIALEDVSITHMTFGKEFTNAVEQKQIAQQEAERAKFVVERAEQEKQAAIIRAEGDAQAAEMISSALAKAGEGFIAFRKIEASKDIAQTLSQTSKVAYLPSGKGEGSNLLLNVGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX68</accession>
    <name>A0A367JX68_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldoketomutase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_011925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000572">
        <property type="protein sequence ID" value="RCH94497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX68"/>
    <dbReference type="STRING" id="86630.A0A367JX68"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="18112" checksum="DF58A7FAF4B0F63A" modified="2018-11-07" version="1">MTDPSKYVFNHTMIRVKDPEASVKFYTEVVGMKLITKLDFEESKFSLYFLAYVDSVPESEEERKKLAFSIPGVLELTHNWGTENQTDFAYCNGNTDNGKGFGHIAIIVDDIQKACERFDSLGVKFVKKLTDGKMKNIAFIADPDNYWVEVIANPRNGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXH8</accession>
    <name>A0A367JXH8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL7A_2</name>
        <name evidence="7" type="ORF">CU097_004385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000554">
        <property type="protein sequence ID" value="RCH94646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXH8"/>
    <dbReference type="STRING" id="86630.A0A367JXH8"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="131"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="272" mass="30386" checksum="D1F9F37A92E97EEE" modified="2018-11-07" version="1">MDGWMKEAPAKKSTGKKVAPAPYPIKGKQTTKAASNPLIEKTPKNFGIGQDVQPKRDVTRFVKWPHYVRLQRQKKILYQRLKVPPALNQFTQVLDKNTATQLFKLLHKYRPESKQEKRERLRAIAAAKAEKKEVPKTDKPLVVKYGINHITALVENKKAQLVVIADDVDPIELVLWLPALCRKMGVPYCIVKGKARLGTLVHKKTATAVALTEVSDADKAELATVVSAVKSNFTDKWEETRRHWGGGVMGPKSNAKMAKRAALAAKEIAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYP8</accession>
    <name>A0A367JYP8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VPS5_4</name>
        <name evidence="3" type="ORF">CU097_012931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000511">
        <property type="protein sequence ID" value="RCH95027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYP8"/>
    <dbReference type="STRING" id="86630.A0A367JYP8"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="531" mass="61533" checksum="97FD5EE420CA9AF6" modified="2018-11-07" version="1">MLQLLQKGQVLKDRLFVFFTQKALFIRMNLTVPEAAATPDTIQFKLVYTDSEGETVVFRTFPQISWIYNRLSKAFLTIVLPPLPEKPLTSQIDDQDYVERKRLQVERFFKKLTSRAELVNQQDFVHFLSSDMTPTEVGPLTTGVLSFLRFNKKPNTDKGFKSYKASELIEGNDQDTFHKHQIYILLQETYFGSIAESLNQLIQVRECLGDALIQMGDLIIETTQSKYRLGPGAKPEARDLQRNLDKRMQIFGLLMDELGFIFTRQGKEENMKFGDVMIEYKNSLDPLKVVFNTRTVSLMDYVEHLKIRNKKRDRADKSKLRLGLNHPEVKQVIAEEIEASQLLEEKKKKFDKVQAKVKQEIKLFENQKIKDLKKAIKDYVNLSIRYEKIKLQNLEKTVNEMQQPVIKSATPFIYQQQQQQQHEEEEQQEEQGMSSSSSGNSSTSKQKKRRQKQKQHLRQNYSELKKPLQSSASLPTRHKNELDHPSDCSETSGNSCLKKAIQVPSKDSESASKISLSASYDDRYLKYPLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZD1</accession>
    <name>A0A367JZD1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000479">
        <property type="protein sequence ID" value="RCH95314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZD1"/>
    <dbReference type="STRING" id="86630.A0A367JZD1"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="581" mass="65503" checksum="05289C5DA769AB37" modified="2018-11-07" version="1">MDYYKILELDPNCSEEDIKKAYRRLALKYHPDKNREPGAAEKASGDKTEKRRIYDNRDSFAQEDDNIPFTTHDNSYYYRTSPLFSTFQFQSPEDIFRQFFGGQDPFKLFFDDPFLSVNRRDPFFDNSPFDEFVGFSQRSSLFDSPLASGAKSVSTKTTIINGKRHTVTTIQDKDGVKVIEDYGDGHQRITVNGVEQPTSITGPSSEQQQQQRIAYNEEPPQKTFNRASVDRTSPVNETSTSVDANRMTHDRHAHACDIYGVIHDGIQAYPFATSALKQLKDNNERVVLLSNSTRLQDKLETSMASKFGIEGTLYEGILSSGTLTKLFLEDIAAYKVSSQQGASCHATVVKEGKQRRMEPKEFADRYLKTGRFFLAGDPDWQEPLYVHLAPTIERVHSYESIDFVLLGSIRGLFPDTNPVDPFDEKAVRRDYQPLLDACLERGIPIICANPDVFAPNGVNQDGSTKLLICPGYIGKMYEQMGGEVLYFGKPFPSIYDYLIAHHSTLENESSSNKIICVGDNVATDVRGATEAGLDVVMILGGVHGQELKQFDNDDALKAYVRDLCRQHGSKEPTYLMPLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZK7</accession>
    <name>A0A367JZK7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000472">
        <property type="protein sequence ID" value="RCH95394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZK7"/>
    <dbReference type="STRING" id="86630.A0A367JZK7"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794900" description="Phospholipase B1, membrane-associated" evidence="1">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42246" checksum="5EB881577EF36950" modified="2018-11-07" version="1">MSILAYLYSILLLPLVTTLPVDPIVNISVPLDIGCPLLKPRSTPAQSVHDLRPDDIKIVAGLGDSVMAGFAAKGVQERFLNIQNLYENRGVSFALGGDPDTITMPNILHYYSHNLYGASVGDHLISICFGNQICPKGQYREDIDILNAAQSGARSLNLDHELDYIMDVLQKAYDDNKVKPTDWKLITIFIGSNDICHSCTEPTSLPVSFAANVQTAIERIRKSMSHVLVQIIGIMKVQDIVVATSNYTDYCRPIKGSNFIGHDHECECSHSEANRTIMNTLFPEYNAALLQAVNYYRQPPSNAFAVVYQPLLVDIMSFPIQAISNIDCFHPSTLAHSWFAKMLWRMMFLPPNEKNMMLKYDASAPIYCPNENDRIQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZP4</accession>
    <name>A0A367JZP4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 complex subunit beta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AP3B2</name>
        <name evidence="8" type="ORF">CU097_005759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000472">
        <property type="protein sequence ID" value="RCH95390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZP4"/>
    <dbReference type="STRING" id="86630.A0A367JZP4"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="733"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="797" mass="89476" checksum="25F5558FA437A6E1" modified="2018-11-07" version="1">MEVSDYINSAKTFAEKAAKFSQKMSQGLVDNARELGLSGGDSGAQYFDTSEEKMRNIKRQLDSKNDREKLDGLKRLIAMISKGRDVSEFFPDVVKNVVSQNIEVRKLVYIYLLRYAEQEPDLALLSINSFQKDLSDKNQIIRAMALRVMSGIRVPVISPIVLLGIKKCITDPSPYVRKTAAHAIPKCYSLDPSQKDALVDIIASLLKDRSSIVIGSTIMAFNEVCPTRYDLIHPCFRRLCSMLIDCDEWGQMSILNVLLRYGRTQFLNPNPHGEDESRSAPKKKTIQPNKSFYSDSSDSDELEADDILEMDVDHELLLKSCIPLLQSRNSGVVLAVAKLFYYLAPASEASKVTKPLVRLLRTHREQSYVVLTNIATMALKRPYLFEPHLQHFYAQSTEPVFIRDTKLDILTTIATEANIHTLLNEFQQYIKSSNKDFVAAAIQAIARCATTVPAAADQCIRLLMKLLHSKNELVIAESVLVLTRLLQVPNEERSKSVIALVKLLDSIHVPKARANIIWLVGQYAEILPKVGPDVLRQAVKGFAKEENVTKLQILTLSAKLICLNPEHPTLILLNQYLLGLARYDTDYDVRDRARFIRALTVPQPSGDKPGLIVLKQHLKDILLSNKESPIIESDAKGASDYMIGSLSLLARQPLPGYEPLPDFPEEQPDSSVRDNDELEGWSGSRTTVMETGFGSDSFEYRSRPSTALSGIEAIGSSSMYPVAAKKKGNEYDLDAFYDDASEEEESSNEESSSEDETEDDTEESEEETESESEEESSEEESSEEEEEEILHHQKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0M8</accession>
    <name>A0A367K0M8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000437">
        <property type="protein sequence ID" value="RCH95730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0M8"/>
    <dbReference type="STRING" id="86630.A0A367K0M8"/>
    <dbReference type="OrthoDB" id="3044029at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016760660" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="334" mass="36052" checksum="D9B7F7E72FF3283C" modified="2018-11-07" version="1">MRTPIAIAVACIAAFITVDAAPSCVQKYTVVSSDKSCSLIAKHAHVSTSVLHKLNANLNSKCSNVKPGQKLCVKTGTSKQAIKKKTTTKKKTTTKKKTTTKKKTTTTKKKTTTKKKTTTKKTTTTKKASKSTTTASKQKPADTAMKPTTTAPTTTTTTTTTTSTAATPTYTYNYGLTAQLSSGQDFCIFLPRSPGNKEDNGGVVDKDAIANSEKSAVAFCTRPNVKAPGARTLPVGFIKTAHYYADNQAGYVQVTGKFEPSLWELSSKDEGGQYDNHGRGSPPLSMCYGYRYYVNMIEPNDSTYCIRCCKSYQDCNAGRSAYGCKRIVPNGVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1F7</accession>
    <name>A0A367K1F7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000410">
        <property type="protein sequence ID" value="RCH96016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1F7"/>
    <dbReference type="OrthoDB" id="10270269at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017050260" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="184" mass="21693" checksum="6F1422811B334B93" modified="2018-11-07" version="1">MEKLILYIALLHLIALVTCEVDWSKPVANVCLELYAPDFGANNGRIGISKDGYGKWALDSDNPWRERYFRFYKWDHGYMRSRVENIWPVDAVVLKGKSGYYIKTGCDDYSVYEPWDWESADLLRLSYVEGSNRFKICHFEWPTICYGRDYNHKRQWIYSDTMGSDHIEFEVKYVDESYCAAQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1V5</accession>
    <name>A0A367K1V5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000397">
        <property type="protein sequence ID" value="RCH96148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1V5"/>
    <dbReference type="STRING" id="86630.A0A367K1V5"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="182"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="379" mass="43376" checksum="B99F1286BC9A479F" modified="2018-11-07" version="1">MTAITTNTAPITNTTANTTTITTMNTHISDNNNHTISAMNIDQAITYQDPLLFQQYPQEDSAIFTDIFKDSSLDQLLGSVYSSPISSPDSSASETLDSPTTLLQDSFLDEFLSNTGDESTIQLDALDQFIQQATQEQSPTDTLQPTMEPVKPRTNKKNQLQGQSTMAIKINNQKTNRPPRKLECFNCKVTKTPLWRRTPDRKHSLCNACGLYYKQYNHHRPLHVRNKTHTVRAHPYDRSLPVTIVRPEMSYPASPVSEQVPEMNQECANCHQTQTPLWRKNERGEPVCNACGLYAKLHHRDRPAEMRKTTIQRRRRDWASEEPQSEMHSFTGLEAEDTRFVSLLLQMDREQMHDFLGMLERRCGFLKTILNSTLENNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1Y5</accession>
    <name>A0A367K1Y5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PEX2</name>
        <name evidence="20" type="ORF">CU097_010245</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="PJQL01000391">
        <property type="protein sequence ID" value="RCH96213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1Y5"/>
    <dbReference type="STRING" id="86630.A0A367K1Y5"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16526">
        <property type="entry name" value="RING-HC_PEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045859">
        <property type="entry name" value="RING-HC_PEX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="282"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH96213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="40435" checksum="68FC73092B479285" modified="2018-11-07" version="1">MKYLPSETAVPDWKLDWKQIQPALDRARKSISSLKSSSLEVMRVSQLDSDILDKELIDILSEQLWSALSYFKTTFKEKYEPELLAVIQLVLFKYSLYDSSATYGAQLQNLKYRNERMHKGPLESIAKDAPLTKSQKIGYGLLTIGGQYVWTRLSRLTTEKGWGELEEDDIRHRAYKILQIVEKYWKLLSFMNFLVFLRNGKYRTLIDRLLCMRLVYAKKSVNREVSFEFLNRQMVWHAFTEFLLFLVPLVNIEKLKLKVMHMLLPKSFILSKGYDQLPLDQCAICHENDNGKDFAIHNPYETNCGHTYCYYCIQSKLSTVGDEWLCLRCGQKVVDIKKFIEIVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3E9</accession>
    <name>A0A367K3E9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000345">
        <property type="protein sequence ID" value="RCH96690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3E9"/>
    <dbReference type="STRING" id="86630.A0A367K3E9"/>
    <dbReference type="OrthoDB" id="2229517at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="18029" checksum="78858C5583EEDCD8" modified="2018-11-07" version="1" fragment="single">ASSFAYLGVPFSPQGKIATDLLIRRNTASAISAMRATLLPIVVSTLPLSGPSLSTVCESASFNLSNSSSLKKHKINFFEWLSMVIIPLQPAPSSIGQPDLGVDSYLTLRMCVHDRSRLLRWRMGWLSGSPIACCGHPHVSRAHLLSCFRVAIRLNVALSNHSNSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3I8</accession>
    <name>A0A367K3I8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000343">
        <property type="protein sequence ID" value="RCH96709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3I8"/>
    <dbReference type="OrthoDB" id="2286040at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="17857" checksum="F3CD20A8359DF07E" modified="2018-11-07" version="1">MTSTAASDDEMQCSFEYYTSCGNFNYTDSQGNVKCVNIDPVNNILTWKFCHKKYKLADAFRKHIFGKACNINDDAARAALEGNDSDDDSISGGDDTVHVALGIVTITLSIQEKEEHNNTRHGYKTAILSAFNALNQSDRDREKKKNFDSTVRGIRVNGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3T4</accession>
    <name>A0A367K3T4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPP2B_1</name>
        <name evidence="5" type="ORF">CU097_007368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000329">
        <property type="protein sequence ID" value="RCH96873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3T4"/>
    <dbReference type="STRING" id="86630.A0A367K3T4"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="10990" checksum="749CBD87413FF6B1" modified="2018-11-07" version="1">MKYLAAYLLLTAGGKTAPTAADVKNILASVGIEAEEERLNTLISSLEGKNVEELIAEGKEKMASVPTGGAVAASSGAAAGAAADAAPAEEKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Y3</accession>
    <name>A0A367K3Y3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000331">
        <property type="protein sequence ID" value="RCH96856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Y3"/>
    <dbReference type="OrthoDB" id="2273778at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="159" mass="18743" checksum="4B83198182DA78F4" modified="2018-11-07" version="1">MFAYRDHILFRWDTFSEVHDESKKKKRPNFIICTSDGIEVGCGEIKLSDTNFSDVEEDRCRAPEHLKKQLYKRLQVASEEMELLMLGFFIFGEELELSKMEFKEGRYEYSIIKLLKLPAMRATFQHMDESLEFLLEFFDMIKSTVAEKNGSVKPTISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K451</accession>
    <name>A0A367K451_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000323">
        <property type="protein sequence ID" value="RCH96940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K451"/>
    <dbReference type="STRING" id="86630.A0A367K451"/>
    <dbReference type="OrthoDB" id="2218971at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="159"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="590" mass="67287" checksum="E1563A1F506CF9F5" modified="2018-11-07" version="1">MFKRKQSATQGESSEKKQKTSTTYNPYSSSTELWRKVFMDAQDAFKQSKFDEAVALFTRALTLEPDHATILDCRSACYEKLGDYPSALADAKKTIHAAPTDARGYLRAGKLLSLQKKYKAAIKTYATALERVKPDDKRYSVIMTMKTSAERALSPPKGLDFMAILPYDVKAMIFSYLSFDRRVQCMAVSKRWRQFALDWNGMWQNLDFGNRGVSQHTIKRYMSYAKGRHIRRLALSDMEQNMMEKVLNLIISEDCQYIETLEFKHCVLPHTLFLRALRLMGKHLVYLNLDGSLGISFYDIFKDVLKMCTKLKRVSIKGIAPMMDNKLFLETEFMKLEPYPTQVEDFRVELQTNVSVFMTMGEKLFCYFPKLRIFEFADATVDFNKLHYLLATHCPQLESLSMGFRHHITRTPLSENASGVQVRHFSVSSLALTPARHIIPFISPKAVETMIFTNVTGVGPVLSRVASLPGGLGQLRTLHLTSVFDIDEDDLISIINACSNLEDLKLTHCQGLNDTVLASFCHVNKLKRLDISQNMVITGAGIKKLIDSQKGSLKKLIMNDCNYIQSDAVQWAKEQLGRNVVECRRTVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4K1</accession>
    <name>A0A367K4K1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin regulatory light polypeptide 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MYL9_1</name>
        <name evidence="5" type="synonym">MYL9_2</name>
        <name evidence="4" type="ORF">CU097_012646</name>
        <name evidence="5" type="ORF">CU097_013782</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000307">
        <property type="protein sequence ID" value="RCH97107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000226">
        <property type="protein sequence ID" value="RCH98071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4K1"/>
    <dbReference type="STRING" id="86630.A0A367K4K1"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="18085" checksum="70755F17FF89CD2C" modified="2018-11-07" version="1">MAPMNKRRQNSNVFAMFDKAQVMEFKDAFSIMDTNSDGLVDMNDLKITFERLGQPATEEEIKEMLGDATTPINFTVFLTLMADKLADIDSENVLLKAFSAFDDDRDGKISADYLRECMMTMGDRFTNEEVDIMFKGSVIDEDGNFNYRDFVRILKHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5L3</accession>
    <name>A0A367K5L3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-actinin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ACTN1</name>
        <name evidence="8" type="ORF">CU097_003207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000275">
        <property type="protein sequence ID" value="RCH97460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K5L3"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="129"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="2349"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2317"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2456"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="892"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2317"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2468"/>
            <end position="2488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2529" mass="291564" checksum="9913EE173D0B2266" modified="2018-11-07" version="1">MTNISTDYQDIQIRTLTKWINVQLKEDLVESIDRDLRDGVMLLRLLSIVSNKPALKPERGRMKIHAISNVSRALNFLKQEFEDDENLPVIASEDIVNGDIKSTLAILFFIMLKYQFSDILGETKKGGLAEAKVGLLYWIRLELKDYINSQIIPTIQDFSKSWKSGLLFCLLIHRIEPEWILPLHQLIPLVDSKDNWNDILNLVFDIGENKLQIPKYLESRDLLDIEYPHEPSIMLYISEFYKIINRTDDIEEHKLKRLKGIQEVQSSPKPKLLNKSNIIDPLSIDLFDHYDPSMLSEDQHHLLNLRLNWEQLFNQAVEWIANTHLELNQFITIARWSGKEDLYTDQVIENIIQSLVAIEGKLSGFDQGLYSNILDLYQQMESIRELPDHLQSRQSGFESAFEDLMKRSSFSRKIVEQLLSVIQVIEKFQQLKTLGEELRDELSSNELDQQDMYSDKVLAFKQDSARFIQNVSSCIPYPSPPEMKTAMGNDDLHDNEVTKEVIESTLNTYSMSLALIAEGLDQLLISRDENISLQQRVSDIQEVIKNLQAWFNDKINSLSTLKPYLYAQSLDQSHSSSSASTHSSSTSVISDSEYSPIMNEEELHRLEKDRDHVLSRLSEIENEDLPRLDEAIRIIEHETSVSQWIDSLDSLKKGRHILTDLLHQRELELDALKRRIEWEAQWSKYHSHLVTLAKKLSDLNVKKVRYDPSKENPDKPSYQGDHELVQSFQWIQDRMGELGDHPWSCLLDSYQEMVMAYLTVMQTTDESAFPEFLSLKQSDIKIKHDDLKHLLTYTSDLMAQRSTITEFLMRVHDAQHEGEKIKEQLAKRLRRMNNEEQDQFGVIEERIDRFKKENKAILADCVEHMPYPVYSGNWLQRQQNSEAAATYRAHVRVQIKSLIEKKIQDLENLEKSLDQVAETYREADRVKHRVAQYEKEADELKQWVDQQIDVLRKQHIEVSAESFLVDSNLQDMEQSRQNLWRQVEKFEQEKVKLLHDQIVQLIESTMQDKKKKQHIDVSVAAQHLGEVMKHLDQLKQGLSDQAVTLEAANMRAAWEKNLNLGIQRLEEMNEQLRDFTTKKNQMLSREDISEQDIQTLERDLNRLMSLKNKFEKTILPSIQMSYDAFIEYFPKLPRPMAVPDHLEVRMESLGRSCTRFQENVMARSRELDLVKQRVSWETTVKKALAYLREQEIELDRFIEQRARWRVATPTDLVQVAHDNDEGQLRTEWYNYYSKFETYQDQVLLPIKQQFEQLTTNTIDYDNPRLVPQAKKMEEIEAAKEHMQHILSFSNDVVSQRCLVSAFILRTAQLEQSAELIREEFISTTNNSQKEDMVHLLENHSDRLHKFKAGIDDARDQLAASIPYPVRATPTETKMADEAINAAIHETIDSRTARLSEICSDLEQLLATRERISRRQLSVHSFKKQAANTEAWITARRKVLMDTAALDVEEEEQMEKALSEIMSIQQGMRANETNYALLTSAYEKCKAAFEDKSLDLVQSQEDHEKLIRELQNEVKPTYQRLSQDWNNLLSSVDQAYRDRQYALLNHKLITWLHSARDLFEATYKEQELSVIEQNIPDWQALTDQLNSSASQYKLDLGYHQQYLEAEQLVQFTNLLQQGHDTIKRIESQLEHHQKTLSVAQLTNKYLTDVKLLRSRIHDCMVCLKDIEQKYRHINTESFEARESQHQALVAEYKASCNTVDQLKGLCDDVRLQFKTIQQIKDHESNNDVQDMLEKTWSGLESFESAVATLVSRASSWMQYFNRLSSIEQDIHSIKTTIESAAEDELSSVQERAETVDFVLLHDLSITTSDLLNDKGNLDAYEELRVQLVKQLAVLKENISAKVKDKNKTRLIEHIQQIVSQFSSLCSKQYNVLDAHSKEVVWLEHQSIEDTIDACGGIIEASNVTLKDCQTQLDTLREVHCQELHSVHHFANTGSLLVPLADALDHLSKSMSLEQEYTKILKQVKTLKSTEKRIIDDAVHAEQSIATVESEEALLDLEHCAESLDEQATEFTTTTKSIDLNNIMQNNERKSSIHNYIKSSTERVLGQVEKVKTMVAEAKVNLKKNIERQRIISKLKEIIGFLHEVSNSLEALQTVNKEALFAEFDKLCQYYSATLSKKEKGLKELVDVVFATPDEMSKDKEISELYKEMTDKTRQIDALINIKKKQVFDEGDLHVMNELMESLEEEIALLITAIDNANPKNVSVAGEKHAKSNLQGLLRSLIASYKHHQPKIVRILENAKKESKKQFADDNAHVSQWLAGGIEKWTKAKAAAAVRERELQDCINQLNNEFFNKLAASRPRRVLPPAPATPVHNKRMSMSATAKSNQPAPSTPIPANKRNDKHINKTIYIPDPKNPLDVELSHIVNASPHRVTVKMIPGEVGKYWFGDENPRLVYCRILPSQMVMVRVGGGWVELSKFLRDHGLTEGAYSKFDSSIEPKRDQTPFQELYLQTARSFSPSGRITLRGGGGNNSSSLASTRSSSKSSSSRSRSPLPGFIDGDKYISMDEAGNHVVVKMKKAEIDAKMPLIKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5L6</accession>
    <name>A0A367K5L6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RRB1_2</name>
        <name evidence="7" type="ORF">CU097_014626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000276">
        <property type="protein sequence ID" value="RCH97455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5L6"/>
    <dbReference type="STRING" id="86630.A0A367K5L6"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="473" mass="53184" checksum="B1BDA574DBA837A3" modified="2018-11-07" version="1">MSKRQADQPDIREQSKLSSFEGRYGKEEKNEMGEFEDNWEDEIEEEEVIEQQEDEDGEGMEVDDEEEVQPDLKVYLPGQPLAEGEVLEADPSVYVMLHNLEVHSPFLSFDILQDKLGDERKNFPATAYIAAGTSIPGVRDNEVLVMKMSSLHKTQQDDSDDEDDPDALDEDPVLEHRSIPHNGCVNRIRLMPYAQEKHIASTWSETGKVHIYDLTQAVDSLEVPGTPAKMSQKPLCTINQHGRDEGYAMDWSRLDVGRLLTGDNSGKIYQTLLTPTGVQTDSVAFREHRSSVEDLQWSPTETTVFASCSSDQTIKIWDTRNKKRSAVSVHASSSDVNVITWNTKAAYLLASGHDDGIFSIWDLRTFKSNNGKPTPVATFKWHHAPITSIEWHPTEESVLAVSGADNQLTLWDLSVEPDTEQDGQMTHEDVPPQLLFVHQGQEDIKELHFHRQIPGCVISTANTGVNIFKTISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K674</accession>
    <name>A0A367K674_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000259">
        <property type="protein sequence ID" value="RCH97656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K674"/>
    <dbReference type="STRING" id="86630.A0A367K674"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="62051" checksum="254C40601DB3D4FE" modified="2018-11-07" version="1">MKYEMFNIVQDYMIQWIEDRKPLYLSNTQWAATLGLLGFASYLLYKMIIYRLYIHPANRLPGPRVSWIPFMGNYFDIVTSNIDESPFRRWSEQYGGIYTVHHNYNEPRVIVTDPKLVKQILTLQVYDFEKPPGPAGFIRRIAGNGLLVTEGNFHRTQRKLLNPAFSIYSIRSMVPLMATPAYKLRDQWLKKIIESKSEYTEIDVSLGFALAALDVVGLTAFGQDFKSVEDYGTERLHRISKAYLNIFNDDFSWKRVWEIDFPFIRYLPSKRLFTMIKSLRWLHEEAEALVEAGIERSKKEKASDMNGRPKDLLALMVDLIDEGSGKGLTKKELKDHCLTFLAAGHETTSSTLSWCFWLLAQHQDVQDRLREEVRVLFQDENSFDYETINSISYLDYVCRETLRFIPTAPRTSRVNRVPVTLGEYTIPKGTVFHILPLYTHRSKEIWGEDADKFNPLRWEKGDHLGGAYEYMPFLAGARQCIGNKFAMLEMKILVAILLHHIQFFEKPGFEVRKIQVITTRPIPNVTLWAKPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7I6</accession>
    <name>A0A367K7I6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000216">
        <property type="protein sequence ID" value="RCH98193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7I6"/>
    <dbReference type="STRING" id="86630.A0A367K7I6"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="258" mass="28843" checksum="9698AB820129989D" modified="2018-11-07" version="1">MTSQQVKATIHIANQAVPVCSAYSKHEINDVLAFQPFKDWLVAFNKQQESRQNEFDFKSVDIQSIDRFGDKIGFIKFKANVQYKKTGKSAPGIVFMRGGAVSMLLVLKAKDEQDKIILTLQPRIPIPHFAFLELPAGMLDGSGNFVGTAAKEIEEETGLKIKEEELVDLTELAYGDQYRGVYPSAGGSDEFLRLFACVKHMNKSEIDELEGKLTGLRDHGENITLRLVSLEDAWKESPDAKLLSSLTLYQALKSKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K865</accession>
    <name>A0A367K865_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000206">
        <property type="protein sequence ID" value="RCH98319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K865"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="85" mass="8764" checksum="3D9921516FAEA258" modified="2018-11-07" version="1">MKRKNQDNLAESSSKGKKTLKSDDLDNSVTSTLTTSASTSLAPPPLDFTPLVSPPVASTSHPSHPLASAASSSSALSPTSKKIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K988</accession>
    <name>A0A367K988_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SFT2</name>
        <name evidence="9" type="ORF">CU097_010742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000171">
        <property type="protein sequence ID" value="RCH98784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K988"/>
    <dbReference type="STRING" id="86630.A0A367K988"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="209" mass="22935" checksum="9A3A44DD0A9A4BDB" modified="2018-11-07" version="1">MSQIESSFKNSLRGFQLSRGNNIALPTNDTAKSAFQSLRESASNTFSSVTNTVQGYIPIGNVEEEEEPWYQLSRMERVLAFALCLALGIGCCCLSFFFLPLFLGKFAATFTLGSVLILVSVALLRGPWAHIKHMISMERLPFTVSYLGSVALTLYAALIARSTTLIIIFSVIQIIALIWYVGSYIPGGVTTLRYGTSYIGRRAVSVLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9K6</accession>
    <name>A0A367K9K6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000161">
        <property type="protein sequence ID" value="RCH98913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9K6"/>
    <dbReference type="OrthoDB" id="2288346at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="286" mass="33496" checksum="1CF0972D433030F6" modified="2018-11-07" version="1">MSTVSFDFEDDLVDLQRFYNKSKVIDLESVDDDEWKHVRRQLVTPAPSVCYERALSRCESVMLFKKISSGESDVECLDLESNDLKDFIDNHSVLMDDYTHTPINTSAISKPYRDERMQETQRKIPNKRLEELQKKITNTSIKAVENDRVKSILARRSSNIIECPQRKRGSFEMEQHRQPIDTVTRIKNNATRTSHQEKGQRRETKKSVTDSARRLLATIQERRKNSIVVEGRFQLLSKSHHHQTQGQSNHKEKYFSKRLDTPPTQPENDYRAFLLSRLPQPVSSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9Z6</accession>
    <name>A0A367K9Z6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000158">
        <property type="protein sequence ID" value="RCH98949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9Z6"/>
    <dbReference type="STRING" id="86630.A0A367K9Z6"/>
    <dbReference type="OrthoDB" id="18145at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="831" mass="95835" checksum="970158E80BE663B0" modified="2018-11-07" version="1">MSNELSSSHSSPEQKALIKTEQYTDLKADINTGNYDRALQTFVSLQSNDYRNPAFQAFAAEVAENLDPHKETDLSKFFASLPFVLQSNIIDFAKEHFQGNGDYIKIFNILFQYIKSYPLHAYKYLIEAINTLILSAQKMEGEEKQQLIKTLVTELFPRLCDYKLLLVRRDIVPSVRNTNEPLICLPYNLFEQFLLLGQRFYIKQHKWKEATQFTCSMLAACGYKGLDDENYISHHDLRLQYLKEHRNTVRVDREELGVDALSVDDFVVLVTVMCEYMAASCQFVQFGYDYYRAVCGMNSENTDDKKSCLIPICIFQPNNNNKPGTSNDKTTIDFSEDTQMTARRKRPRLDYAEDNEEEKIEQERNQGLDSYCVKGVDDTLHILSQAGDCLRHIVELWQWASDRISENELVDHFGNWEKELCRVIESYKLPFDMHNAVLLVRSDLALSSPSVPGNLAKALELSQNICDRIDAQRREEKTHGESVDADIPLMFTFRVLYNIGIIYLLVGSLQQSTLEIAIILSVFPIPDELEEKDFLMDEIDCCTVANIFHGREFGLMRVTQEGLVVRCIKHLVVGLDNESEQKGGMASIDSALRWDEKAGNMIVMMQYGWPYWYKRTNLWQKIISKISEKRIFKNREFLEYLYVSDVLNAILQLHLTAKVTMDIIPPEFALRGSYKHLVTSENSSRNTANTNDTPSDQSNEAQNEEDHEIATRRHLPLYQPTFANTILPSTSMSPSWYSASTQKNSFAQWMSPSFYYSRPATSVILPDAEERGPNDDGQTAETKGTYVPREMVTRCLEYRIRKYPPKITPQRMRHVLQRFLKNMVLKANEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA13</accession>
    <name>A0A367KA13_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000152">
        <property type="protein sequence ID" value="RCH99025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA13"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="77376" checksum="B5E64E1D0F7CED14" modified="2018-11-07" version="1">MNDNHYKVTIQQSTSISNTDTNNTMDQEQSSFPEMEKMIHNLSVIDKITIPKHQTLGESDMSISSYAQRRPKELPPNRMGPREQEEADEYIRKATDYLFNNQFMEAKSIFQRKIDSDPLYANGLGLMTFIKAIMTRDKNDIKLALSVLKTAEKVATCQINAKGVKKGYSISNYLSSLIVPNQTGLPSSPQTCSKREVTEIESPFLANGTLRAYVVKAEACLLRGALQILQDDTLELINCSSSLHQAYSNYTIVWQEYKKMGQAYTKHMDRNTVSALYFGLGSLHLLVSCFPLHLVKSFWIHGFTCNQQLGFALLKICIESKCIKSPFASLILLCYYLILCSQTSQLYTQELMKSALECLAEAQKKYPKSCIFFYIAGKLSRIAKNLQLSTQSFRGALSSCTEEWVQSSLKQTTTYEIAMNHILQLDWKSAAKCFKELQKASPSVFYQYMIGACQLMRGKRTKGILSLAQIPDMVVQDRPSSLEAYALQKVETFQKKGYQDINYYLPGLELLFIWDAFEQMEDTTLEKCLGLVQSTLESIYEREKLEYNIRAKQIAPSVGLPDYYDQRILLLLIKVSIFNALKKYDKSIAHINWIVDNLEHLKTEAWVIPFVYWEAGVTSWGLSDYAKSKEVWEFAMSHTKDPLGYQLMLRLSIALRKCNEMNIKSPEPAREQSHQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA59</accession>
    <name>A0A367KA59_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000152">
        <property type="protein sequence ID" value="RCH99030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA59"/>
    <dbReference type="OrthoDB" id="10305823at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="171" mass="20530" checksum="69450CFB2B038B1B" modified="2018-11-07" version="1">MSMNDAKQQPSLDDTLKESAYYMEDTSEYNKSNREAFKEYLRRHQDELRNKRNFHKGNFTSRTFKLSPVSRDFRNVTKHAHPNLNHKYTPLEKWLKQQKKEQTPRPVKEKQIAQEKDEKTEDEVLMEQLKNEISKLDSEIFRLEQQYAASRKKCDFVSVKLLCMRMTYGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB46</accession>
    <name>A0A367KB46_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_014769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000126">
        <property type="protein sequence ID" value="RCH99396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB46"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="150" mass="16915" checksum="82F70E4088E0B5E9" modified="2018-11-07" version="1">MSPVVLIRVLLGSGVSEQAKLEKFKSIRLKPASLKGYIRSSLKGEDYPAIVHTGKEQDKVAGILCEGLSELDVRALDTFEGEDYLRSPVRVTVDEDQTTVETDVYHYVGDSTLLTYTEWTLTEFISTGKEGKWLEDRVMFYQVDLVHLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBA2</accession>
    <name>A0A367KBA2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">GLT1_2</name>
        <name evidence="27" type="ORF">CU097_013602</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="PJQL01000123">
        <property type="protein sequence ID" value="RCH99447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KBA2"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000207">
        <property type="entry name" value="Glutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000124">
        <property type="entry name" value="Glutamate synthase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="30"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1148"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1154"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1159"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RCH99447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2066" mass="228262" checksum="3647ED09DC5172F5" modified="2018-11-07" version="1">MSINNENKSWAGAIPPAQGLYNPEFEKDACGVGFMVHVKGVRSHKILSEASYILCNMTHRGASGADIRDGDGAGVMTGIPHEFFVNETSRLLGISLPPEGQYAVGNLFMKGDAESVAESKKVFEQLAEALHLKVLGWRTVPRDSSIIGPAARSKEPAIEQPFVVLADQSKEFDEPYFERQLYVLRKHATHTLTMKKWFYICSLSNKNIVYKGQLTPKQVYLYFHDLNNVQYTTHFALVHSRFSTNTFPSWDRAQPMRWCAHNGEINTVRGNKNWMRSREGVMASDKFGNELDLLYPIIEEGGSDSAAFDNVLELLVINGVLTLPEAVMMMIPEAWQNHEQMSPEVKAFYQWAASLMEPWDGPALFTFSDGRYCGASLDRNGLRPCRYYLTSDDIMICASEVGTVFIDPETVVEKGRLKPGRMLLVDTVEGIIVDDKQLKLQTAAKRNFQEWIKNQNIILKDIVEKTDKVQQIPALDETTVQADPRLKAFGYTLEQLNLIMVPLASTGKEPLGSMGNDTALACLAEQPRLIYEYFRELFAQVTNPPIDPIREEIVMSLECYVGPKGNILEMDESQCHQLALPSPILSMQELAAIKSMSDVYPSWKVQTIDITFAKSEGVEGYVNTLERICKEVSTAIDNGYKIIVLSDRAVNAERVAISSLIAAGGVHHYLVRSKQRSRIALMVETGEAREVHHFCVLLGYGVDAVCPYLAMEAMVKLCREKAVHEGLTPEKLIYNFKKGIDNGILKVMSKMGISTLASYKGAQIFEALGVDDSVISRCFSGTASRIKGVTFDIFALDALTLHETGYPTRNTVQPVGLPESGEYHWRDGGAPHIAEPNGIANLQDAVRQKNQSSYDAYSRNAYEAIKKCTLRGMLDFDYDNAKPIPIDQVESWDKIVKRFVTGAMSYGSISMEAHSSLAIAMNKLGGKSNTGEGGEKPERSKPLDNGDSMRSAIKQVASGRFGVTSFYLSDSDELQIKMAQGAKPGEGGELAGSKVSEEIASTRKTTPGIGLISPPPHHDIYSIEDLKQLIYDLKCSNPRARVSVKLVSEVGVGIVAAGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVIVQTDGQIKTGRDIAIACLLGAEEWGFATTPLIALGCIMMRKCHLNTCPVGIATQDPELRKKFEGSPEHVINFFYYLAEELRGIMAKLGFRTINEMVGRADMLKVNESLRTFKTANLDLSPILTPASSLRPNVANYCVTKQKHNLHIRLDNYFIEEAESALTNKEKVYIEADVVNTDRALGTTLSYHVSKRHGENGLPSDTIHIKLKGSAGQSLGAFLAPGIFFELEGDSNDYVGKGLSGGKIAIYPPKSSTFKSEDNVIVGNVCLYGATSGKAFFRGIAAERFCVRNSGAHAVCEGVGDHGCEYMTGGRVVILGSTGRNFAAGMSGGIAYVLDVNDQFKKNVNLEMVELDTVNDEERIAELRDLIEDHRHYTGSEIADRVLKNFNEYLPKFVMVMPTEYRALLEKQRAEKNAVAAPKPCEEIHKKKAEPQVEDLEDSVLAEEAVLARRAKLDKVRGFMKYKRRTDRYRDAKKRLGDWKEINDRLTRSQLHEQAARCMDCGVPFCQSDTGCPIGNIIPKWNELVYKDNWKEALDRLLMTNNFPEFTGRVCPAPCENACVLGITEPPVAIKSIECAIIDRAFQEGWIVPQPPAQRTGKKIAIIGSGPAGLAAADQLNKAGHLVTVYDRNDRMGGLLMYGIPNMKLDKKIVQRRIDLMAAEGITFVPNAHIGVDVDANAIREENDALIVATGATWPRDLKIPGRELDGIHFAMEFLQANTKSLLDSDLKDGQYLSAKDKRVIVIGGGDTGNDCIGTSLRHGCKSVVNFELLPQPPNTRAPDNPWPQFARVFKVDYGHSEVIAQTGRDPREYCVLSKRFVGNADGKLTGIETVRVEWIKSEDGKWSMKEVPGSEQFFEADLILLSMGFLGPETSLIKQLELKQDVRSNIETPKSKYSTSVPGVYAAGDCRRGQSLIVWGINEGRQCAREVDADLMGNTYLPVPGGIQQRIVETIEVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBN6</accession>
    <name>A0A367KBN6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TAF10</name>
        <name evidence="8" type="ORF">CU097_015210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000113">
        <property type="protein sequence ID" value="RCH99586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBN6"/>
    <dbReference type="STRING" id="86630.A0A367KBN6"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15639" checksum="04DF0E86F443F2C2" modified="2018-11-07" version="1">MTEPTPTADNSNIQPHPSSLTSSSSTPKQETQETPKRERTMAEFLALMDNYAPIIPDAVTDYYLSKSGFDCDDVRIKRLLALATQKFIADIATDAFQHCKVRQSGNRKTGKERKTVLTMEDLSAALAEYGVNVKKPEYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBQ0</accession>
    <name>A0A367KBQ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000112">
        <property type="protein sequence ID" value="RCH99598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBQ0"/>
    <dbReference type="STRING" id="86630.A0A367KBQ0"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="165"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="268" mass="30833" checksum="936CBEED43460B2D" modified="2018-11-07" version="1">MCPENYTSSLYLSIMNHTSNSRAVDRWSISKEESFYSPSIEDGMSLEEEFAWRMRGVCFIQIAGSRLELPLPVVGTASTLFHRFYTVASLYEFPYDKIAATCLFVACKSEETARRAFDIAKIWSFGSEEDIYEEDINEFADEILNYELIVVDLTCFDLDIDHPYYYLYDICEQIQVPEEVINTCVAMMNDSYRLPFIQWYGNRLMAVVLLMMSFCGCEVEYEIDPASELAHYMEEHSQVIPEIVGSVMDMYKLFSTIYASPTGSPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBU7</accession>
    <name>A0A367KBU7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000105">
        <property type="protein sequence ID" value="RCH99704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBU7"/>
    <dbReference type="STRING" id="86630.A0A367KBU7"/>
    <dbReference type="OrthoDB" id="2317955at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="350" mass="40802" checksum="1E97E411A18941BE" modified="2018-11-07" version="1">MQGISDENLRTPRLMLRTYRASDHDQIDHLFYSTYFVLVPEGVKSKLKSPLFWVVWFGFYSYLMAIVPILLADLSVPSWTSTALKVFLTISWFLVSFAGVFVFTDRFEAVDQVEQARMNDLSDPEIYYLNWIKEEIELEEESISTSDGKKRVTFDKDAKPATEIKRSQKPIEEQTPSHFWVLTLDNKPCGMIGLAHYRERLYSNRPTQPPAWKLMSAAVLRRYRLPVPEYLNDLYNKMPPNVFAEPHEEKVATLQRLAIRNEFQGSGLSTLLIDRAMVFAHEKGLERVEAVTNELQTKAAEILRVKHGFTLIKKQKKGWFGQYEKTWSCNVNDWMESHRKEAQTFMPNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC44</accession>
    <name>A0A367KC44_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000126">
        <property type="protein sequence ID" value="RCH99401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC44"/>
    <dbReference type="STRING" id="86630.A0A367KC44"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="25810" checksum="381C422F144D458E" modified="2018-11-07" version="1">MSHAPRNSFIAPGVSRYSRSAVYSKKALYKRKKTAVAAPAQQAAADKTVEVKGAKNGGKRVVPAQKAPRFYPAEDVPQPKVTRKTSKKTVLRSNITPGTVAILLAGRYRGKRVVVLKQLDSGLLLVTGPFKINGVPLRRVNQAYVIATSTKLDLSNVKIDEKFNDAYFKKSAKTEKAFLQGEEKKAAFPESKAADQKAVDKALLEVVVKTPFLRQYLSSTFSLRKGQFPHDMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD67</accession>
    <name>A0A367KD67_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_014519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000075">
        <property type="protein sequence ID" value="RCI00194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KD67"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1902"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1931"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1977"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2069"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2110"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2146"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2188"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2229"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2257"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2288"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="10">
        <location>
            <begin position="581"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="1900"/>
            <end position="2308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2325" mass="262900" checksum="3B3075BEC1685D41" modified="2018-11-07" version="1">MDNKDTRPVRLPKVLFNSWAALVDKYFEAHPNNKPIAPVIPLQRLISLGDAPWNKQVACIKESAKLLQKLLDQPSETELDQVRHLVDPIASLGYFAAQENLSRRMFVPMIESCAKYLKDSFFKSYYMKYIMDKTTEPCFEDKPLSQKALTIYAMLKYPLGQQVIADYFYETLEYMTNGLQNARDQIRNMKNSAKTLNASADQFLGDIEFISKTILVLFSRQLQAGPELFKKAEAGLKDDHELMLLSRVVRTLLDICLDTSSYSKECNQVAGMAIGAFLNLANNAETTRDLVLGCFFTNTKTVETEKIISTLDISDMFVRFIETQCWQGRDAPIIFILRGLSSSLRKEVILLDCPPDLCFIDPLKGQSFKNLNEIIFFSIDLFCQTPNLDASCKVVVFESMATWLQQTKEIMEHNKEKHIIDSVSGPIHSKNMDRLVYYVWDHWDDPIDSIQHKVRSIFELVLSLMQIKSNFYNQDHTYNEFLHHLLKNMINMDWHKKVKYALLNMLVEKVETDTFLKVEPRLIEKCLQAMDSLILCPQITYFLLTFLYRRIQDTIPGHEKFNGHNGKVKYDSNSKHAVDEWIALWALPLLQSLTSSFELVRKNASGFLLQPLFKVSSQSFWFLVNILQDVHDPRWKEDKFDSRFRLNAFIAVLKSARALDIIDGNAYTSEPTLEKTKIPIDVLKLAVHHSDPQVRIDVLGLLCESRKATAEVTFIELDMVKMFLPLNMNSTAPEFRQQMCAHLTKLWVRLRGNLYSQYRAYKLSETKDAKKGASDATDIMARIEQGRSFLFWLCDFISDSLYPGASYQRVATALRMLSILVKTFGVTELPPIEGFTDRQPEFPFQLPLATARLSKLLINVFMNPYDFNRVQAFDILNQFPSPLPGIESKLDVQNLLWWGLNNVVSTRANESDSGAMVFRLIFKKYVVHLGFDLNPEQGKLHESTFNEKTSAAVIFTERLLDLLERQVAVAKSNLLLAAQQHPMHGTLLALQYVFSELDYRSDTVQKHFVDWKKVHKRAVCLIKEACDAALDVLSDPSPEGNLPLNYQETDDMDEQLLDESLEGTTSGPKHQIILSCCWRAVKEASSLLQVMISNVPITSQDATHTIFTLEDLVDAGELFHSLLTNIRHRGAFSSVYPAYVSLNMKLLAVKDLSISQLPSRWLQNDLDGLTSTNISITRRSAGLPLCILAVLSSEQSIKRELLASAMKQLMTLAGQEPPKDADQRIDLPQVHAYNIMRSIFMDSKLGNHVLEYVSKGFSLAISGFSSFSWAIRNCSVMLFSTLLQRTFGTKKTKDEHSHVNTLTGREFFVRFPELHPYLLKELKVAVEHLLNNPTAASVHPGLYPMLTLLSRMKPSLEKEEEQDNVLAPFIPLVMPCAASAIYKTREMAARALVPLVHDVNGVITQLMELGDNLTQNQIHGRLLQVKFILHGHFYSSSAKPQVFTQFVQLAPSVILKSLELLEKERFCHMNGALLLSITAEFFFDTTWMTFELLQSSTSSFAELQLTAVSICQRIISNSQLHGIGAYLLRQAAANIVLLNALNRPDHDIDDVLYLIEDRDYEVRLLALEKLLTHFKKHETNKDGSCLRTFEGENYQNCYVKAAKLLLTLQPVAPYPASSSKFTIQQYWYKLVDNIAEKRPLSIKESVLPLLGSLLEQIYHMGDKEWAQHCLTVWSNFISLYSQKEMSLPLREAAVKSIKHASKFLFSQEQSMNTARDAKVAVLISITQLLQDDDVDVRMDTAQIVSDALHLQSPVHHERALELVNRYLIENYGSCHLLKAALSSILANEESLTVYKAILALHVQIGLLGNTEQSTVTDSLMPLLEDSECINQPLITHHSPSPEANLAGAVREYAELDFEDSISYSVADRAQQYRPLLEQNDEALDEYDDLEQKQYRLPSEGGSIFTSFLNMANSIIGAGIIGLPFAFKEAGFWTGLFLLIALTIIVDWTVRLLIHNGKLSGTSTYQDLMEFTFGKPGLIAISIFQFAFAFGGMAAYCVIIGKLKHEIKAPVTNNNVGDTIPHVIRSLFPKVDQVPLLWMLADRNLCISFFTLFVSYPLSLYRDISKLAKTSALALVAIIIIIIAVAIEGPQMPSSIRGSSALRFNIINNEAFQAIAVMSFAFVCHHNSFLIFGSLRQPSLNRFATVTHWSMGIAFFTCLLLAVSGYWAFTDKTVGNILNNFPSDNILINIARLAFGLNMFTTIPLEAFVCREVLETYFWPSAKFDKMRHFFITSVLILTTVAISLLTCNLGIVLELTGAFSATVLAFVLPPLCFLKLSNGPLFHSSKICHWACTIFGLIIMFISTFYSIRKALLPSSSTSNSEVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDB4</accession>
    <name>A0A367KDB4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000075">
        <property type="protein sequence ID" value="RCI00196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDB4"/>
    <dbReference type="OrthoDB" id="2229978at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="18449" checksum="1B6EC04D83F6010A" modified="2018-11-07" version="1">MAESLESFKLPLKWKPGADLMSKMLLSDPEIIRIIIHSFIDVYVPPESYSVAPTEWADTKGVYTLYTSQNTSNEKFIPILAAFQEEVNQATILETIERLTLVYKNFRILPTVLVISIKSRRIGDGLVTVTLHDRSFFCRQTFFKLTQGQQKTHTEHTYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDE8</accession>
    <name>A0A367KDE8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SWIRM-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_014336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000073">
        <property type="protein sequence ID" value="RCI00218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDE8"/>
    <dbReference type="STRING" id="86630.A0A367KDE8"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="275"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63846" checksum="FD18C0EFE8A71C3A" modified="2018-11-07" version="1">MEQQQSTSMDTNSPKDNIKKETHPSEAENNVNNEQSTTKTEPLTTTRSVIEVEARKYLMEQTKPVKVPSYASWFDFNSIHPIERVALPEFFTNNNSSKTPTIYQDYRDFMINTYRLNPKEYLTVTACRRSLAGDVCAIMRVHAFLEQWGLINCECDPFTWPSSIGPPYTGHFRVTADTPRGLAPYKPNIKPSTSSAPKGELNIELRQKVFEAANGTSTRECFCITCGAECSRERYHSLKIKNMDLCPLCYKEGRFPASCFSSDFIHYSRQQEKQENSEKWSDEETLLLLEAIELYDDDWNTIADYVGTKTREQCIYHFLQLPIEDPYRSIDGNVHSSVVDHKRIPFSQADNPVMSILAFLASTVDPEVASTAAKAAIACQEQQKRKNEDDMELDKEQPNKKPRTLIEKAASVALGSAAAKAKSLSSIEEREIRRLVHSVLEAEIKKVELKMNYFDEMEAVLEYEMEALAQQRKDVFTYRLSVKKTEALLEQEINKRGGVEMAIENGWTPQELQQLIHNSLFKEDYHLVDMSTLNESTLVHPSTRMDESESAKDAPSVLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDI6</accession>
    <name>A0A367KDI6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPS4_2</name>
        <name evidence="9" type="ORF">CU097_012625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000068">
        <property type="protein sequence ID" value="RCI00303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDI6"/>
    <dbReference type="STRING" id="86630.A0A367KDI6"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="263" mass="29716" checksum="B8325204CC126F53" modified="2018-11-07" version="1">MARGPKKHMKRLAAPKHWMLDKLLGNYAPKPSSGPHKTRECLPLIVFIRNRLKYALNGREVQSILMQRLVKVDGKVRTDSTFPAGFMDVIQIEKTGENFRLVYDVKGRFAVHRITDEEAKYKLCKVKKVLVGAKGIPYITTHDGRTIRYPDPLIKANDTIRFNLETGKIEDFVKFDVGNVVMVTGGRNIGRVGQLIHRERHIGGFEIVHIKDALDRVFATRISNVFTIGQGTKPWISLPKGKGVKLSITEERDRRRAAAAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEG7</accession>
    <name>A0A367KEG7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-40S ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UBI::CRP6</name>
        <name evidence="8" type="ORF">CU097_005348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000056">
        <property type="protein sequence ID" value="RCI00510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEG7"/>
    <dbReference type="STRING" id="86630.A0A367KEG7"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="155" mass="17132" checksum="D299F2C237541AF6" modified="2018-11-07" version="1">MQVFVKSLQGNTFALDVSSNTSVAAVKSMIEAREGLPVNAQCLSYAGKSLVEGELALYGIADNNTLHLNAELLGGGKKRKKKTYTTPKKIKHKRKKVKMAVLKYYKVDESGKITRLRRECPNATCGAGVFMAKHKDRQYCGKCHLTYVFQKGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEL8</accession>
    <name>A0A367KEL8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_014330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000047">
        <property type="protein sequence ID" value="RCI00665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEL8"/>
    <dbReference type="STRING" id="86630.A0A367KEL8"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="406"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="651" mass="73343" checksum="C3404ABC4E95BB30" modified="2018-11-07" version="1">MVALTNNGQLKQSISDLTTETKSTKGDIPPALVGASTTVIGNDLYVFGGRVASSRQMTNHLYILNLPTLVWMRHIAPPDSALPPSPRYFHSATAYKNRYIVIFGGMSNVSPTNRRKQAPNDEKLYAMDDIAMFDVETMSWIEIQSSPSIFTPQARYAHLATIWNDDKFVIFGGQDANNQHVYETNVFDLKDSSWIHGGPIQGSYDAYRAVAFCPSSDNISSYYGKLSTPFWDRSYDDKPPVCIYANYNFNDLTRDLHSFWPLKSPHTAELHPHEMSGSLLPPGLRFPTGQLVGQYFLVSGTLLTPTQRGYHIWALNLTNLSWTHIDTGKMMTQGSWNRGLLSGQKYYVLGHSQRDLKEDYSYRRINFDHIGIVDLEAFGIFELPRATCSPLAQELGLAMIDEPTISDITIWTSDQQSVAANSTILAERWPDFAQLLQEDQNQEKKILYFPETYAVTVAFLQYLYTDHVMTAQQHQPQILARLLVLADMYHIDRLRQLTTFALHQLLTISTASLVYETATLTFQNALQIRALRVLLNTKRLLQQQKDHQQHLPPPLPQTPMEEWTPSVPPSPAITLHGSSGASYYSSGDEYSYPGSPPPSSYSFTNLRRLAQPPPTPTEPRYLYSSPSKSAPVSSSPIPKKKIPEYGLFNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFC4</accession>
    <name>A0A367KFC4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydropteridine reductase</fullName>
            <ecNumber evidence="6">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000033">
        <property type="protein sequence ID" value="RCI00924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFC4"/>
    <dbReference type="STRING" id="86630.A0A367KFC4"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="235" mass="24602" checksum="C218A4A58976E165" modified="2018-11-07" version="1">MASKKLVVYGGAGALGRTLVQHFKSKGYTVINVDLIENTEADFNTLTSTTGSLKEQGESIQNAISQVLGGEKLSAIFCVAGGWAGGNAHNKEFLASSELMIQQSVYSSLIAAQLASNHLQPGGLLTLTGALAALSPTPGMIGYGLAKSAVHHLVQDLAQPNGGLPQDAKVAGILPVTIDTPMNRRFMPKADFSTWTSPSDIATQLEGYLDGSIPLTNGKLIKVVTENSKTTFTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFI5</accession>
    <name>A0A367KFI5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000052">
        <property type="protein sequence ID" value="RCI00582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFI5"/>
    <dbReference type="OrthoDB" id="2261494at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="13182" checksum="129110426E4B2CC9" modified="2018-11-07" version="1">MDYFTLLAPEETIYELWLEDFLEIKPDIDDKLEAIPNFLQFYWKMKKLLKETSKMAMELKKEHDSTLIENRFKPSSFLSSLSLMVNLSILRLTEEKDKAGMNNLGPLFFPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGI9</accession>
    <name>A0A367KGI9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000017">
        <property type="protein sequence ID" value="RCI01288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGI9"/>
    <dbReference type="OrthoDB" id="2340857at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016603637" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="188" mass="20410" checksum="BA01ECDF06A2870E" modified="2018-11-07" version="1" fragment="single">MKFSITAISALILSTAVSMTTADSYSDAMKSWCGGLGVSFPTSSTVVTAGSKTKVTVTRKPDQRTKTVTGLDLYSVDSSGKAKYVQNVWSGKYNLQKTASITDTIPSNVAPGLYYYRVWVTNMVNGQHGPDCLQTSHTFKVTSSSHKNADGTMEYAESLDDENIYHPDHYNGCFGLTVDYPAPNGEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGL7</accession>
    <name>A0A367KGL7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COX11_2</name>
        <name evidence="7" type="ORF">CU097_010888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000015">
        <property type="protein sequence ID" value="RCI01317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGL7"/>
    <dbReference type="STRING" id="86630.A0A367KGL7"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="238" mass="27571" checksum="2E02712AE27BEC1B" modified="2018-11-07" version="1">MFKSNLCQRRLIEHAFRPIYRNTLWRRQQLPIQKRTLMTSPQNKGWNQENISAGMYTASIFIFMLGLSYAAVPLYRLFCASTGFNGTPVIDAERFGPDRLVPQTKSKRIRVTFESNTSDTLPWSFKPELREIYVVPGETALTFYKAKSRAKQDIIGIATYNVTPYRAGSYFNKIQCFCFEEQKLSPEEEVDMPVFFFIDPDFLEDPLMKDVNTITLSYTFFNSQHAKGLKPVQQQHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGV3</accession>
    <name>A0A367KGV3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_015234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000009">
        <property type="protein sequence ID" value="RCI01455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGV3"/>
    <dbReference type="STRING" id="86630.A0A367KGV3"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="49"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI01455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="517" mass="57408" checksum="E362CEF664AEC4BD" modified="2018-11-07" version="1">MPDSSLTTYSYVTIAIFLLVVLLVIKPVTIRIKKIKLYFNLSTAPPLGVLILLICRAINFDVVRKGFLGTLGIQPWSILILFYSLAYICISLDMTGVFQFCAFWVSRKAGNRGLLAFTLFFILTSLMSGLTSNDVVILTGTVFLSYFTKVTGIQPTAFLVSEFTTANIASMALYIGNPTNVIVSEAYNISFITYSAWMLLPTIVTLLMAYLVLRIVFHSEKYLPRHIQPPDADPKSVLIDGQGAIFGLVLLGCCLVTLVATSFASVPVWMVTLPFAIVMLIRDIKHDLGISMRVLLRVKQRQARSDVSVEPIELDTISSGTLDPKDETESRFKQQKKLKRFLNWSSRRLPTIRAVSLRMPWSILPFSLGMFMLIEALAERGWVGIFATAMAVFAKNYATAVLGMTFVSILACQLLNNLPMTILFTQIIQHPNFTIHVSSDAVMQGFLLGLIVGSNLGACLTLVGSLAGIMFDHILKTKGIYLLGYFQFLKWNLIILPLLAASASAIVIGEIWFIYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJT5</accession>
    <name>A0A367IJT5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock 70 kDa protein 12A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSPA12A_1</name>
        <name evidence="1" type="ORF">CU097_000607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005538">
        <property type="protein sequence ID" value="RCH77930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJT5"/>
    <dbReference type="STRING" id="86630.A0A367IJT5"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="14166" checksum="578F2E8BD5125549" modified="2018-11-07" version="1" fragment="single">QYSHETGKLVQWGRFARSNKADQGNILVIQQFKIYLDENPQRPLANLPLGLTPTVIISDYLEKMFAYVKTYMSQKGFSNDFEKRARFCITVPAMWSDQAKQIMRNAAIQANLIQLTDHRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK26</accession>
    <name>A0A367IK26_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005478">
        <property type="protein sequence ID" value="RCH78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK26"/>
    <dbReference type="STRING" id="86630.A0A367IK26"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="61" mass="7118" checksum="C84FF57DAF75CF27" modified="2018-11-07" version="1" fragment="single">MTFSNKLNVNEKQKSRISRRLTVDTQEPYISIRPVIKKADKEAAYTLSESYLNNNLLSWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKS0</accession>
    <name>A0A367IKS0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005306">
        <property type="protein sequence ID" value="RCH78258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKS0"/>
    <dbReference type="OrthoDB" id="2224160at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16336" checksum="32D069D5B6ED6CE4" modified="2018-11-07" version="1" fragment="single">PVAFEDFEFTLGYDFAVPIDFNELEDIPFNPEAHSHVLDEDERDMFNQFLDQFDTDGDIHMDPSAFSFPVQVDEDGLCESFLLHSLDDRNNVIEDNSEYEHGASLLKEATNRLGYLCSSTQSTGNISSGLNTSNTNHYGELTVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMA9</accession>
    <name>A0A367IMA9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004895">
        <property type="protein sequence ID" value="RCH78820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMA9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="12537" checksum="A270224F88FD331A" modified="2018-11-07" version="1" fragment="single">CQIKKVGLLALKRLKERLAEYRTTTAWGYTYLQQTEWWEINCSYNKVELEAVGLLSRLWNAFEPLMGRLSYLTHDEERKDEYGILKRKETSAALDNCLPKANEKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMR6</accession>
    <name>A0A367IMR6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004790">
        <property type="protein sequence ID" value="RCH78964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMR6"/>
    <dbReference type="STRING" id="86630.A0A367IMR6"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="32739" checksum="74B57168254FC9CF" modified="2018-11-07" version="1">MVASSERVFIVGGTGNVGVKVVKDLVAKNIPVTLYARQPEKVSALFDKSSLISVIQGDYNDLAPIKEGLKGHTRLLLLIADLQSMVHLKKTIATWAYEAGVKQVVDVSSLSASFPLRTTFNGAQHYEAEQAIYNIPNRGTFVALRPGRFMSNMLTFERIHEDAIIDKSDPDTREGWVSTNDIGAVAAVVLSEDVDKHGDSVYELISDVVTPAQRAEIFSRVLGRPIKYRKVTALEKYDMLMQHKVFNHFMAFSICTTPASFNPQTPTVTDGIQILLRREPETFKKFITDNKHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPM5</accession>
    <name>A0A367IPM5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004391">
        <property type="protein sequence ID" value="RCH79615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPM5"/>
    <dbReference type="STRING" id="86630.A0A367IPM5"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF12">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="224" mass="26280" checksum="469F6114682696A2" modified="2018-11-07" version="1" fragment="single">TITEPAQLIPRKQRYTNKAPKTNKEQKIFDRHCQLWYDKYKDSDNSDIMGPDGCQAFFSDIGVSLESITPLIIAWKMNCSRMGYITKNEWQHGMKALNVENESKLKVALSTAEQCIEKHDKEFEGLYNFCYPYAKSENQKSMDVEVAIALWQVLLVNRYPIVKSFIQFLQEKKPVKVINKDQWRSLLEFGRDIPEDLSGYDPVSYWPVLFDDFVEWKKKQESDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPS1</accession>
    <name>A0A367IPS1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome-associated kinesin kif4a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KIF4A</name>
        <name evidence="8" type="ORF">CU097_000749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004378">
        <property type="protein sequence ID" value="RCH79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPS1"/>
    <dbReference type="STRING" id="86630.A0A367IPS1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="12187" checksum="577DAB1E150A12C9" modified="2018-11-07" version="1" fragment="single">MSVCTVRVALRVRPLLEKEETKSCITFIPNQPQVIVDQNRQFTFDHVYSPSVTQEEVYLSCIQPLFDQFVKGYNATVLAYGQTGSGKTYNMGTSYHHQDPKHYGIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQV5</accession>
    <name>A0A367IQV5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004238">
        <property type="protein sequence ID" value="RCH79871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQV5"/>
    <dbReference type="STRING" id="86630.A0A367IQV5"/>
    <dbReference type="OrthoDB" id="2259334at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="12341" checksum="392299B74E076A33" modified="2018-11-07" version="1">MRTFHAKKVLCKCQPLAAQGDTLNLASVSQQTHAEPTATTISTSTSSSIPTPTEPRPLEPTATELVLAEDKPEAAWRASLKRSIEALEVDLKQKEREVHAIKKKIKVLKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRH6</accession>
    <name>A0A367IRH6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004020">
        <property type="protein sequence ID" value="RCH80246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRH6"/>
    <dbReference type="OrthoDB" id="2414043at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="216" mass="25601" checksum="6AA3276B6C5FA889" modified="2018-11-07" version="1">MKSVRFSFVNKKFDDQYTFELQGYLSIADFNSSFRLLNQTVAKHPPPGSKNIWITAIVVLWISALVIDYILWSHYRFSSELITLPFFMVLTTLLFIWRHRVMRERFERSIVDVCNRINATENIRGINYRFNKNGSDLNDVTKQMYIHAGTGLKPHYSIVIEFDDRYNALSSHQFNRHSSIDFVTIPLYAHVRHEKNEKNSPFWAAQQHEYDEKPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRL9</accession>
    <name>A0A367IRL9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GYP5_2</name>
        <name evidence="5" type="ORF">CU097_002554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003989">
        <property type="protein sequence ID" value="RCH80302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRL9"/>
    <dbReference type="STRING" id="86630.A0A367IRL9"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="229"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH80302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="445" mass="51424" checksum="FB3139CD23C813F4" modified="2018-11-07" version="1" fragment="single">MTATEMNDNNQFMSKELNNESSITIGASSIEDKCYSDAESSSLDTIATHQENDTMETKTTRRNRSATITENNHYIPNKEEEKKKEQETIKEEPVMAESIGDNNTKELVDGLHQMMEHGHQDEYSDSENSVEGTKHHTRYESHRSTMSSIHSYMSSASNYDLLLARLDNNNNSSTHISSNDNLEELRKSVEKDGPSAEDIDWEFWSKVISDFNNVSKSEAKVLSYQIQKGIPPSLRGMVWQLFSKSKNVKLEDQYMQLLKEESVYEKAITRDLPKLSMLKEEHQKEAIFNIMKAYSLYDKDVGYSQQLIYITAPLLLNMPEEEAFCVLVQLMNKYGLRGHFLPQSDLLSKRLYQLSGLISDQLPHLQRHFEAHGIKSNTYAYQWFSTLFAYKFPIDTVYRIYDMIFAEGMETLFRFSLALLEKNQSILLSLEYDDLIGFLKNNLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITI4</accession>
    <name>A0A367ITI4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003649">
        <property type="protein sequence ID" value="RCH80962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITI4"/>
    <dbReference type="STRING" id="86630.A0A367ITI4"/>
    <dbReference type="OrthoDB" id="438080at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF3">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT SNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="17090" checksum="12875D2BFB946507" modified="2018-11-07" version="1">MQQPIQQTGRLDFLSNASQLMFNVCPSLSRFYMSEFQQALIEYELKPTKQMERSACQSCGEIAIPGLNTTVRVIQKNRKERKKKHLKAKNLIETTCLTCFRVKLYHGSFKNKLQQKEEQVIALLAKQQEKKPNSNSSSNSLLGDFLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU12</accession>
    <name>A0A367IU12_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GLK1_1</name>
        <name evidence="14" type="ORF">CU097_004606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01003544">
        <property type="protein sequence ID" value="RCH81185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU12"/>
    <dbReference type="STRING" id="86630.A0A367IU12"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="51"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH81185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="335" mass="37774" checksum="643100A40E820DEF" modified="2018-11-07" version="1" fragment="single">GFTIKGLEGHDLSDLLHAAFQRRGVPVRVTALVNDTVGTLVAHAYTNPKTRIGFIYGTGVNAAYPEEVRRITKLHGYQQKGKMLINTEIDIFGSESYLPLNKYDRELDKNHSQPKFQLYEKMMSGAYIGELVRLAALDLIQQGHLFQRHRPKEFDVPLEFDTAIPSDIESCLELAPQERLARFSSHFSFSSDDNYVPTLHDLSIFTQICLSVSNRAAQLAAAAMVSLIEQQDNLLRSTKPIVIGINGSTFEKYPAMSSRIQQSLTTWFGPKISQRIQLEIATDGGSIGGALIAMLAEKEQKTTYLQQLSRFSCLWQWLSFFRSNDKADKEKDRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVK3</accession>
    <name>A0A367IVK3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase C signaling pathway involved MAPKK protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MKK1_1</name>
        <name evidence="7" type="ORF">CU097_000267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003345">
        <property type="protein sequence ID" value="RCH81646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVK3"/>
    <dbReference type="STRING" id="86630.A0A367IVK3"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="131" mass="15036" checksum="BADF02A0D450671A" modified="2018-11-07" version="1" fragment="single">LINSLAQTFTGTQYYMAPERIQGNAYAVQSDIWSLGLTLIEVSQNRPALPPPDQPHLSIFELLDFIVRQPVPEITGSHISDECKNFVAVCLTKDPNYRPTPARMLQHPFILKWEHVHMDLGQWVKEVWGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVW7</accession>
    <name>A0A367IVW7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase mtr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MTR4_2</name>
        <name evidence="12" type="ORF">CU097_002041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003360">
        <property type="protein sequence ID" value="RCH81611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVW7"/>
    <dbReference type="STRING" id="86630.A0A367IVW7"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="156"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH81611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="830" mass="94839" checksum="09E509DECAC97649" modified="2018-11-07" version="1">MTTEILRSMLYRGSEIIREVAWVVYDEIHYMRDSERGVVWEESIILLPDAVRYVFLSATIPNAMEFAEWICKIHQQPCHIVYTDFRPTPLQHYLFPAGGDGIHLVVDEKSRFREDNFQRAIAALSDARGDDPSGPNSRGKKGKTYKGGNSSDGPPDIYRIIKMIMMKNYHPVIVFSFSKRECEANALVMSKLDFNDDSERDMVNQVFTNAISGLNEDDRQLPQIQQLLPLLRRGIGVHHGGLLPIMKETIEVLFQEGLLKVLFATETFSIGLNMPAKTVVFTSVRKYDGKSTRWVTSGEYIQMSGRAGRRGLDERGVVIMMIDEKMEPAVAKGMVKGESDRMNSAFHLSYNMILNLLRVEGVSPEYMLEKCFYTFQNDANIPQFENQMKQLVAEKDSIQIEGEEEISTYYELRKQIDTYTQDVRDVMLHPTYSLPFMQPGRLVRVEYEKMDFGWGAVLNCQKLNSRKRASDQDSEPNYVVDILLNCSKDSSLTKDAAGQPTGIKPATNDDERNPLVIPVSLRTIQSISHIRLVLPKDLRSSDTRKAAYKSIMEVKKRFHGNIPLLDPINNMGIKDPSFQKLVNKILNLEKRVMDHPLTKSPDLPVLYETYTRKMEITEKIKDLKRKLVEAQSIVQLEELKNRKRVLRRLGFTTSSDVVEMKGRVACEISSGDELLLTEMIFQGVFNDLTVDQSVAVLSCFVFDEKVDAKAKLQEELSAPLRLMQETARRIAKVANECKMNLDEEEYVGKFKPELMDVVFAWCQGAKFSQICKMTTVYEGSLIRVFRRLEELLRQMCAAAKSIGNSELENKFSEGINRIHRDIIFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZD7</accession>
    <name>A0A367IZD7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_005372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002791">
        <property type="protein sequence ID" value="RCH83053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZD7"/>
    <dbReference type="STRING" id="86630.A0A367IZD7"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="386"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH83053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="683" mass="76645" checksum="40B653BCFE016505" modified="2018-11-07" version="1">MTSGTQTITGFTTEFKLTSGDIPPPLVGASTTVVNSRLYVFGGRLVSSRQMTNHLYILDLDTLVWTRHIAEPDSPPPPRPRYFHSTNHYGRYLVVFGGMSYSTKRSSQSLCALDDICLFDLDLMVWKYPEVQPSLYTPQARYAHLSVFAEDKLVIIGGQDMSNQYINEINVYCMTTCSWISGGPVSKQYGAYRSIAFYPSNIHRNSMPASPFWADDSDSDTPVVCIYSNYNFTDVTRDLESFSAIPPAAEFKNHSAEMSGFSLPPGLRFPSGHMLGHHMILTGTYLTPTYKAFNIWALNLANLVWVKIDPGSVLAQGSWNKGVLYEKKRQFIILGDRGRDLLEDYSHRQTNFNHVAVMDLEAFGIYTFPEETCAPVAQELGLSMLSEPSMADMEIITEDNRSIPVNSNVMLLRWPRFAEVLAEKEHVASGFKRLLFPESYPVTLAFLQFIYTDHLVTAQQYQPQILVRLLLLSEIYNIPRLGELSTHALHQALTINTASMIYEAAVLTGKMALQIRALRVLFNTKKKMMQQQQQQQQQQQQHQYQQYGELPLSPTILDSPSVFPVHYSTTSPQPTSPVGQRRSNEEDGFPLRPTPPVSSSAVRRMAGSKSSTTVSPDSNYFYSIPAPKLSKSSTLYHASQKVPSSAVERPRKASLSPYSNPYGQNSSGPISPTYDKPHSSFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J001</accession>
    <name>A0A367J001_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002728">
        <property type="protein sequence ID" value="RCH83240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J001"/>
    <dbReference type="OrthoDB" id="2225454at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="23068" checksum="25A560E749598E3E" modified="2018-11-07" version="1">MTTNSQSVKEAITALDQEKAVHEYVKQACDSFRTEGMIYLDQLPHETRQLTVEEFYSKYGESIEAYFGQQRENKLEQLDEIVENPTAKRENRSDDLILDDNESFIDLELPVEEADLREGAPEMGPIFIRLERKDRSNISIKLDPNKTVPELGKYMLIAPDNILWQLEDQTHRHRVWEQIEDIRSQLELFQNRLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0J4</accession>
    <name>A0A367J0J4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002656">
        <property type="protein sequence ID" value="RCH83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0J4"/>
    <dbReference type="STRING" id="86630.A0A367J0J4"/>
    <dbReference type="OrthoDB" id="2255287at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1036" mass="124304" checksum="6C926B2E9711B2C6" modified="2018-11-07" version="1">MTPSRGTDRKRPRAERLSILSTATADDVIKEAEERVKEFYEQGNEWKRRASTVSLEKTELENKMRELSKYYKTQIKTLVDEIERLKGASNSKNYDQEDEEESRDELEQLKKSADHVRKLLNTAELEKAKLQIEMNDMRRKQSSLDVKSREEIHALKEQNMNLSRENEKMREQLSRIDIQRSQLQKQLELVLKEKDEQGKSKAELSTEVTSLTLKLRKRAEEIEYLNKVLKDKSMDLDRVSQEKDERLKGIENVTNERIRQLEIDKHRLEDKLKEKEETIEDQRYESERKIEKLEEQVENSSSRIEDLERKEYEATREIETLKDRIRDLQEKLSLANDSTKHMKDVERNINELEEKLKEKEEEMENQRYDSARRIEELEEQVEDGSNRIADLERREYEATREVETLQNRIKDLQETLELANDSTKHMKDVERHIDELEEKLKEKEEEIENQRYDSARRIEELEEQVENSSNRIEDLERKEYEATREVETLQNRIKDLQEKLSLANDSAKHMENVERLMQELQEEHDKKQKLSEEENNHLRSRIKALQEKVNVLEQKLKETKENAENITNTLERLLYEKRKEFESKDRLSAQKIQQLETRNQELQKDLAYREARITEIIEDTSKQMRVLEDLLEEKRKAYEQTDDIKNQKIDELETHIQVLQGKLSLAERKSEEMKNEARTFEDILHEKEEEYERKYNAVSQQVKQLEDHSRSLRNKLLLAERRVEEVMQEKADYSSSVHMMEEKQQEYEYTINDLNTALKNKQDELERKDRSLNQTIRHLENHIQTLQDKLTFAEEELEERKEEIIKQANNLHVLIKEKESLSYKEQSANQRIHHLEADVRSLEAKLLDAEKKNSESLNRARTLENILREKQDEFDRQSRTANNKIQELEDQRHILHEKLIYTEEKIAELNDQNEQLENDRRRLENTELLVAERSERISQLEANVEIIMRDLSKAMEHKKIMEKKYKELQDKLEGANADIYQLEMQLRKTETDLKESHQVIKESERIIEDKEQTIRHIKDSIRVLLEEKKTVNTHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J188</accession>
    <name>A0A367J188_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002647">
        <property type="protein sequence ID" value="RCH83481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J188"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="213" mass="24672" checksum="3722AA0CD8BDF0C3" modified="2018-11-07" version="1">MDHTLSGWLFKLSTTNKLGSSKWQSRYFVLLDTELRYYKHEHSVDPSCAISLHEVSRVVKTSTFNHNYCFKLETTTNYKQRHAKRQKTWTMECHSEYELDVWFQAINARLAKLRQYHSLPCPSNVKPRSFKRSNLSISRRRGIVLSPLEFESMPVLDHETLSSSSSSKASTIPSPNINTSETYDSIIQQGYENQATNLIMQHDYTPSSKQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2X5</accession>
    <name>A0A367J2X5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_005543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01002407">
        <property type="protein sequence ID" value="RCH84292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2X5"/>
    <dbReference type="STRING" id="86630.A0A367J2X5"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="222"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH84292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="317" mass="34735" checksum="6AF046CBCB82671A" modified="2018-11-07" version="1">MSRILNYGSVNIDEFFSVPHICQPGETLSSTEYIVRAGGKGANQSIACAKAGARVYHAGKFGHDAAWVRDYMQKNGIDVTFAELKENERNGRAFIQVSADTGDNCIVLYPGTNATYTAEEAEKVIDHFGPQDWIVMQNEISEGGEIMKRAASRGLSILFNPAPMTKGILEVFPFENISILVVNEHEARSLYEELGGKEKVAGLNLAERLLSEFKAMQGVIITLGGEGVVAKFRKDKEEKDFKVAGCKVNVKDTTGAGDTFVGFFLAAFIRYEKEAYFDRVQMALKEANVASSLAVQKEGSMASVPTLKEVLECMESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3A2</accession>
    <name>A0A367J3A2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002395">
        <property type="protein sequence ID" value="RCH84329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3A2"/>
    <dbReference type="STRING" id="86630.A0A367J3A2"/>
    <dbReference type="OrthoDB" id="10461665at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="33555" checksum="FBC9EB46F05BC851" modified="2018-11-07" version="1">MAEVPPVVPQPEVSAAPHSAAPSAAPTAPVVNDAPPSQTGIPTQSHSAAPIPSQPAAPISTAAAPTVISGPSRAPQAAVVPHSSMYRNNVGIMEGLFNKLKVAAGFGDPFTTYYPGNAFVQPLMPQANIQIPSIVDDNIMKPQAIAPALPIPMNPALGMAPVNHYQQQQQLQQAQQLLMLLMMNQQQQQQHPYVYQQQLQLQQQQQQQQMLVNYFIQQQQAAMMAAVQRSEMMYPATIMNTYPQYHMPYYSQYQHRMYPYEDYARSYYNPSYYDTRYRTNSFYPQRTRNFSSVKDLRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3D6</accession>
    <name>A0A367J3D6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_006472</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002365">
        <property type="protein sequence ID" value="RCH84440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3D6"/>
    <dbReference type="STRING" id="86630.A0A367J3D6"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH84440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32690" checksum="512F9BA1C65F1F96" modified="2018-11-07" version="1">MSDNVAHALSGAGGGIVSMVLTYPLVSISSRLQVQKNDASKDAYKNTLDAFFKILAKEGPKGLYSGLSSGVFGIAITNGVYYYCYEAVKAIFEKAKGKGKPMSTAESMAAGAIAGCAVVLATHPIWTVNTRLTVKKGVEGDEKKTKSNALEVGLQILKKDGIAGLYAGVGAALVLVINPIIQYTVFEQVKNKIAKMKTLSNFDFFLLGAISKLCATAITYPYIVIKSRMQVSQQGEEKYESILDGFKKIIANEGVTGLYKGISSKIVQSVLTAAFLFMAKEVLFDWSVWVLVLLGARKRAAVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3G3</accession>
    <name>A0A367J3G3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002360">
        <property type="protein sequence ID" value="RCH84456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3G3"/>
    <dbReference type="STRING" id="86630.A0A367J3G3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016843775" description="Helicase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="14612" checksum="6A46A2B4DF952703" modified="2018-11-07" version="1">MIFSFFFFIFYSLFIDTNCSLDVKDVKYVINYDFPTNIEDYIHRVGRTGRGGNTGHSFTYFTAENARQARDLVDILNQTNQPVDPRLQLLVQTSHGSGFGSGRRGGGGFRGGRGGYGGYNRYNNNGGNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3I0</accession>
    <name>A0A367J3I0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002351">
        <property type="protein sequence ID" value="RCH84490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3I0"/>
    <dbReference type="OrthoDB" id="10396808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="270" mass="30807" checksum="6EE1653B939C7E80" modified="2018-11-07" version="1">MTAVQDNSDEPTEIMAVSSEDHGSSIEHIKDEPSIIQDMDGPPSEHIVEHQEEEYQEVKEEKHQEKEEDQEEEHQEESEEELQEESKEEQEKITICDDRETSDCEDNSALVKEEMNNTDRQKSIGSPANEQNKPEDHEENKCDSEFEEHAKVCLPDFMDTPKKRHSMMVIPNRPNNGVKTQQRKSQQNHPSYIPVSVKRLSIVRSPVDTLEGYSSESSTSSGSSSTHSHQTAFESKIPKFMDKSVTIKHVSSVGSKLPKRKSYVAPVYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3I2</accession>
    <name>A0A367J3I2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">YKT6_1</name>
        <name evidence="13" type="ORF">CU097_003925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002355">
        <property type="protein sequence ID" value="RCH84473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3I2"/>
    <dbReference type="STRING" id="86630.A0A367J3I2"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH84473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="22087" checksum="1DF3488A5AC78691" modified="2018-11-07" version="1">MKIFAILVLRKDADKAKILASQYDLSSFNFFQRGTVKEIMDFSATTITERTSAGQRQSVESENNVVHIYMHPQGASGIIISDKDYPTRVAFSLLNKIMDEVFTKYPQWKTSATIDYSELAEYINKYQDPQQADTIMKVQKELDETTAILHKTIDSVLQRGEKLDSLVDRSEALSAQSKMFYKTARKTNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3J7</accession>
    <name>A0A367J3J7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002350">
        <property type="protein sequence ID" value="RCH84495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3J7"/>
    <dbReference type="STRING" id="86630.A0A367J3J7"/>
    <dbReference type="OrthoDB" id="5598885at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="88" mass="9823" checksum="1303181817FA0727" modified="2018-11-07" version="1">MVTAEEVNQVAEKLEETQIESAEENNDQATEDTGAGSETAAKKKKKNKKKKKGPKTQTEPPTVPVSKIYTNKVYPVGECHDYVNEYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4P5</accession>
    <name>A0A367J4P5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002243">
        <property type="protein sequence ID" value="RCH84876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4P5"/>
    <dbReference type="STRING" id="86630.A0A367J4P5"/>
    <dbReference type="OrthoDB" id="2283268at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26858" checksum="ADF8D4DF9E15BF9B" modified="2018-11-07" version="1" fragment="single">MVMQKSMESEKEEMLKETNSTPIFSEKETQAIGHLFGKRSIKQQDIDDVDYVAAAIVKGRMKSTAGKWLLSSFEIAEKKAKESETALSRTDSKQRNSQYGTIDYVWPFKRDLEDRIVNNEKKKECILETADVGADGFCGFRSLAANIKGNQDLFWEVKWDMLQCFYKNRGIYSKYFATMFDLERLERSVSSGLEAIDSGRKVSFCPLEYWFSTPQCAQLAVDTYRVPTVVYPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4S5</accession>
    <name>A0A367J4S5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PEX3</name>
        <name evidence="2" type="ORF">CU097_007129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002236">
        <property type="protein sequence ID" value="RCH84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4S5"/>
    <dbReference type="STRING" id="86630.A0A367J4S5"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="456" mass="52476" checksum="2214C1133CC369DB" modified="2018-11-07" version="1">MTLITSVKDYIKRHRKGIFITTAIAGGSYLAGKYAATKIRDMQERATAERLAKENLKRRFQQNQNDCVFTVLSLLPTLGQQILDELNIEAEWAKLQKSRDLEKIEKKLKEEREMAYVIKEEKEVDQQVEGASNTLDSSIVSLSTSEHSEDSNATLPPGILDKKQKQLIWEDIKLKSFVRTFTSIYSITFLTLLTHIQLNLLGRFTYMWSVSVLNKSEPTIRLQQEGQQADAGYLNPQTEHMFLSASWWLIHRGWKQCAKRVEEAVDEIVSGISLKQSFNYRDADELVQKLRKRIEYDQNDEPISYRTWMLPETEEEELEYLTQTGFGDSVHQQETSTITLRKLLDETKDYIDSSDFHQVLNSCLNEVFAIFDHHAFVKSLLPDLEPTVPSIQEVSQEQEAQSQEKSLTLAKLLPIISRQAHLVIAGNEYLNAFAYIKELQAFSAVIYTQYDSEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J562</accession>
    <name>A0A367J562_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_005517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002188">
        <property type="protein sequence ID" value="RCH85082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J562"/>
    <dbReference type="STRING" id="86630.A0A367J562"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="148"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="256"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="418" mass="45597" checksum="5C3A717DCF82432B" modified="2018-11-07" version="1">MLRSSLSRLRPIIRQYSSEASPAPLGMAFSLTEEQKSIQEMARKFTKEEIIPVAAEHDQTGKYPWEIIKKAWELGLVNTHIESKYGGMELGVFDSALISEELAYGCSGIQTAIEANNLAEAPLVVAGNDFQKKKYLGRMTEEPLVASYGVTEPGAGSDVAGLRTQAVKKADGSWVLNGQKMWITNAGHANWFFVLARTNPDAPTGSAFTGFIVDADTPGITLGRKEINMGQRASDTRGVTFEDVVVPAENVLGREGEGFKIAMKAFDITRPLVAAGAVGLARRAMEEATKYSLERKTMGKPIFNHQAIAFMLADMIMNIEASRLMVYRSAWMRDQGQRNTWYASMAKAMASETANKCAADAVQIFGGNGFNTEYPVEKLMRDAKIFMIYEGTSQIQRLVVSRGLADLAQSGASALGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5W4</accession>
    <name>A0A367J5W4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002122">
        <property type="protein sequence ID" value="RCH85342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5W4"/>
    <dbReference type="STRING" id="86630.A0A367J5W4"/>
    <dbReference type="OrthoDB" id="2263777at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016761552" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50990" checksum="CA0EA9FA18A8456C" modified="2018-11-07" version="1" fragment="single">MQIVRILGLLAISASVKATILNSRVLSSCGYISNKIYCYGGDISNVVNVFRPEGRLYVLDIGQMYGQQSSTFNNKWNEVIASNDFDVEVRRAPEYIFFPEQNQIVIVGGFSSDTPFTNQTIAYDTVSNTWKSLPAYSEPNRPRRQIYFATTVNLMSATNDTAAFYGGYESLPSTTVPMISSTGQNITNINNGTSIRGFDSLTVFNITSQTWSYFSPQQVFPDSDFYPNSQSATFNPRTGKIYYFGGSYYLHTNYGPIRFPFSKTYIFNTIQGTWSLQPLAAAVGSSVPSDRIYHTTTLLPNSDHILLYGGTNDGRIGLTDFCYTLDLTTYEWTNQVNVTVPTSVSESGVRYGHSAVLVNTTLFILFGSDINGNGSPNMLTFDISNVSNIQYTPTYPLLPATAGNSSKPDNSNNNTTTSVPSSAELSSGAKAGIAVGCVLGVAAIAGTIFFFIRRKRGTKGGEEVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J753</accession>
    <name>A0A367J753_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002015">
        <property type="protein sequence ID" value="RCH85784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J753"/>
    <dbReference type="STRING" id="86630.A0A367J753"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="34015" checksum="998B38E939B51AE4" modified="2018-11-07" version="1">MTDVFKQFIQSSTIGNLIDKVKPIEQQRDLIDLPATATIEEALDLLLAEDIKSVPIYELDQNEKKYIMIVSALDLLRLICSQITEDINSQIEVKEELLLIPLKEAIHFSEHLTILKSSELIDKLIGLFTIEHRALVDYDSKLVLLSQMDLIQYLQLENHKIGSNVLDLTVESIKYNEIKSMISYKTTAVEAFLKLGADSRVTSLPIIDDTEEFIAELSSNDLRGLNRERLSALRKPVIMYLKESHGSLPAPMTCHFNFTLSQLLSAFILRNTNKLWCLDPNTGQLKAVITLTDIITTLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J793</accession>
    <name>A0A367J793_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large subunit GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002006">
        <property type="protein sequence ID" value="RCH85824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J793"/>
    <dbReference type="STRING" id="86630.A0A367J793"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21328" checksum="D318347B155B183B" modified="2018-11-07" version="1" fragment="single">MAPKKKQSSSLGRAVIKSRFQGQKTFGVDEGKLQHTTDIDEGPKWVKMQSITQENDLEAFLSTAALADTDFTAERLNVKVIQNDYTNPLLMDDDEDQKRRIAKQEASIDRLSVPRRPHWDKSMTAEQVQRNERESFLNWRRSMAQLEDEEGLLLTPFERNIEVWRQLWRVIERSQLVVQIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8I2</accession>
    <name>A0A367J8I2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001918">
        <property type="protein sequence ID" value="RCH86205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8I2"/>
    <dbReference type="STRING" id="86630.A0A367J8I2"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="152" mass="17536" checksum="77AF95DC5663BFCA" modified="2018-11-07" version="1">MDDSDYEYEEETNYVLFNVGTTITDEYIDSVSKTQGGCRIIGLQEGKPYLQIGNQFFEGEIDDTIGTHLLFEIQESKRETTGLLPLLSSMRSKDDDKKKQKYNLTFACSTEKMVHFDSVTLEPKMDAEAINEAKMKEESQKRQKDEMDNIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8R4</accession>
    <name>A0A367J8R4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001886">
        <property type="protein sequence ID" value="RCH86354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8R4"/>
    <dbReference type="STRING" id="86630.A0A367J8R4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04206">
        <property type="entry name" value="CuRO_1_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04207">
        <property type="entry name" value="CuRO_3_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016735384" description="L-ascorbate oxidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="248"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="561"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH86354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="80875" checksum="82C7D1A2A71ECB6D" modified="2018-11-07" version="1">MKRLIIGSLLFTLCHAALRQFELNISYKDINPDCHSRSFRVPTINGLFPGPTLYATQGDEIEILVRNSLPNANTSIHYHGIRQIGSTESDGVPGVTQDAITPGSTFVHRFLLHQQAGTYFYHAHVGLQDDSVQGAFIIYESPEADPNAHKSIEKRSCKDKDSSSSDDDDVEFSDIGDYDLAYDHSYSRHHDHHDHYYDNSRVYDEVADNYDDEENYDYDEDYDPAYVTPKIHKQKPQLRAGPYTYQKDLVLQLSEWWHDELDSRQDYYMGSVFKYDHGSDSILINGRTVHDPSETSKETCPGYTTFDVEPNTVYRLRIIGGNTFRTLALAIKHHNMTLIEVDGELVHPYETSFLEVTPGQRFSVLLRTGDYTPGMVFAIGTSYLWRQRGRGITENGFGYIRYVEREREDNVSYLFKPLTTGGNSRKKGNHQWNGKKDKRADEDHHNGHDNRGGWGGKEGGGGGGGGGGWGNHHRPQPFIEELPTFPKLDRPDWLWHNIAPLADRDPILDEMDVRTIKLHTTMNQMSDNTTRYLVNHRINPDRHIPVIHHYRHFRHHHHKRATDEYDDNYYTDLHTYRIAYNETVDLVFQNSKNRDGGCLLHPWHTHGHSHYVIASGPGDYNHTLHKHIRNFEHPLYKDTSVAYPYFSNDGSEGCGWTKVRIKADNPGFWAVHCHITTHMIQGKMIVLEEAPDLISRFSLYNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J952</accession>
    <name>A0A367J952_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_004902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001864">
        <property type="protein sequence ID" value="RCH86446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J952"/>
    <dbReference type="STRING" id="86630.A0A367J952"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH86446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="694" mass="78682" checksum="01E9D8F298AEAE62" modified="2018-11-07" version="1">MEEYQNGSSMFGKKRVRATQACILCRKKKIKCDGTKPHCLHCQESNLNCEYTESKKRGPRKGYVQLLEDRLAQLERRLTVATNDNLMDDKKEDLDNDFPEPEIVTHLIDLFFQYINSVFPFVHRARLKQSIANGTVSKPLLWSVMAIAARFSDHPSIRTDPPYWAGERYAMKATSLINASLLEPTIANLQFWGIMSCLEYGRASGSKAWTYGGIAVRMCQELGLHKEETLKAPITAPDGTLDYVAMALRRRIFWSCFCIDKFSSTSTNRPQGFEIGDYDVRPPTVAESKILRDPLQAYTVDKVLIDDDPLMDSIGEYLSILELFGDIAKYMSRAKTDYSSVIWPPIKEHEDLNRRMELWVTNLPDIYKFTPDNVKLYRETASENYINFWLCSHAIYCAGMLSLHRGSLAYSDLSSAEIPIETYERIQTSIASCKTHVDIAMEVFSKLRDFCGCNVLPYMGYAAYIFATVLMTSTFSSDPILYNRSSKGLAVLFDTIKLLRPYWPVGERLALTTQDMLAAHSRLYDVQEQEENQKKKYEHNLKQINSPAAKTSSVSSTDTGLLSQPMPMPATSSELAYPPAFIDSNVQPYYNQQQPPLPLQQQQQQQQQLGVGSNEIDFSSSEFLYDSALFGQMILDTSKPPNMTANMFSYYPPASTSASTTTTTSTSNTPYPIVTPMYHQTPYSAFSYQQPPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9U3</accession>
    <name>A0A367J9U3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-trefoil</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001851">
        <property type="protein sequence ID" value="RCH86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9U3"/>
    <dbReference type="STRING" id="86630.A0A367J9U3"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="8">
        <location>
            <begin position="164"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53813" checksum="FF6DCCDB8CFE0076" modified="2018-11-07" version="1">MTPMESLLSAIDKADPIQLPLPRKRKASMSIDHIIEKRQYSPPQSPKSCHKIICYHASVAQKSYGTEKRFLCPPPIVMTTPNQSSTVVSMSIINDQNQPTLEQRAVLDDESKGYFKYLFVNSATKQKQFKLKINLQDLTFYSNPISIISKPSKKTAKITRNASSCLFNHSIISLFNRINSQTVRTKYMSSDNHQLCAKHASWSPFEIIVTRQPQQQQQPYPHHHSTAITFGTEIILKDIHTGTTSPPLILRKVEKGQIVHDATGLLSQMQKVALQLANAPHQYLNSNGKSMHPTEASGNVFIDFSSSTMNDQQQELVDDYLCWTIVGISRFEYEYQHNTFMPIQHPHSPPPSPPRTIIPFPIIKSIEYIPSTHKLKLSNLEHSLDYWLGRHGPLKKSTSTQEIELPDVQEVILNNHDLLVVKSDGKRYLELPLLLSRHDGFIYHSSKLLSYEFVLNSPESGVWSLLDAMLHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAL7</accession>
    <name>A0A367JAL7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001776">
        <property type="protein sequence ID" value="RCH86879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAL7"/>
    <dbReference type="STRING" id="86630.A0A367JAL7"/>
    <dbReference type="OrthoDB" id="2441332at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="117" mass="13363" checksum="03621C6900A8B4AA" modified="2018-11-07" version="1">MNAIEKPVITRNLGVQNNYKSVDEKGWHNEWYQIRRQAMIPDFTLYSDPLTVTNFELFVVEVKKSGSFSNGHLETDIVKLGKEMQLALDKFIEKKVKSPKVVALLVECNKVGFSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAV4</accession>
    <name>A0A367JAV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carotene oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001739">
        <property type="protein sequence ID" value="RCH87050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAV4"/>
    <dbReference type="STRING" id="86630.A0A367JAV4"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="70774" checksum="D480BC182110D21F" modified="2018-11-07" version="1">MITLAENNPNKDKNEPAPSPSGFKNVPACEAPVQLEVHGKIPSWVNGVFYRTGAGRYNILMNNGDTFHIEHPFDGLAMLHRFEISGETQEIHYNSRHTSHGTERRYKEQDKTLLTFGPDPCKTIFGRIQSVFHHIVKYSTNVALLEKDPEFEMVNVTITPNFPLGERLEKETGIKRGDALVVKRDANTLQVVDKDTLKPIKAFTYGHVNEQLQGQLCASHHQYDEETDEYINFTVKLGPVPSFQTFSISPYLPTSPGGKEKASEQQVRVHQPIWRHLGAWKTIEALKPSYIHSFSLTKNYIIIPNFPYYYSYGGLSALYYSNAYQTFYWDETRHTLFHVIDRHTGHHIATYEAEPCFSFHVANAWDEDIELPGGHKERVIFMDYCMYENTDIIDASFELGKSPSGKINLDKVQPARFVKATANKAEHKIAPAQFRRYRLGQVPVSKPDTEKWSSFWSDLTPPSLTAYNKRRVASYTVIGYDIELPRFNPQYNLKKYRYCYGVCESRHAPPYASGSVVNGLIKLDLDQPYLGSNTYLDSPSKIWDEPNCSCSEPVFIPNPDGTKEDDGVILSIVNSSTKDGSESCFLLILDAATMKEVSRSTIGAFNAVTLHGSFTDRFGRGIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDW9</accession>
    <name>A0A367JDW9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001526">
        <property type="protein sequence ID" value="RCH88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDW9"/>
    <dbReference type="OrthoDB" id="2201602at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="12122" checksum="3FF9AFF3D663058D" modified="2018-11-07" version="1" fragment="single">QVWYFDDNNQLVNVFTGHLIGYDNSDPGLPNVTVLMQKPNERSPEFQWTYDTNTKRIYNKVKGQDAEWWPHYENDRAYIVVKKGAHQDPNWDKFEIIYKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG05</accession>
    <name>A0A367JG05_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kti12, chromatin associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KTI12_2</name>
        <name evidence="5" type="ORF">CU097_008914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001391">
        <property type="protein sequence ID" value="RCH88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG05"/>
    <dbReference type="STRING" id="86630.A0A367JG05"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000827">
        <property type="entry name" value="KTI12 chromatin-associated homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="32153" checksum="63D877602BABD4BD" modified="2018-11-07" version="1">MPLIVLTGYPSSGKTQRTNEIKEYLTKRLAEENKSLRIHIIDDHSLHVPKAAYKDAREEKKARGALLSAVERLLSKDDIVIADGLNYIKGFRYQLYCVARAIGTPHCVVHTGVPADIAKEWNRSRNDEKYDDIVFDELVSRYEEPDERNRWDSPLFTIIYDDKEIPGDKLWDAVILKKPPPPNKSTVSKPVSSTNYVYELDKATLEIINAFVEQQKELGPGGMPMTVPRSTVKVINPSRTVTLSELRRLRKQFVTYNKMNTTLDVNRLGDVFVEYLNTNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGW8</accession>
    <name>A0A367JGW8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001342">
        <property type="protein sequence ID" value="RCH89136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGW8"/>
    <dbReference type="STRING" id="86630.A0A367JGW8"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="250" mass="29171" checksum="8A717CDD67E1F4B8" modified="2018-11-07" version="1">MAKSIVPSVKNNVKRDPPTTVHLKGWLYKQKHGKSKAFHKRYFILYGEELRYYKNQNDTIALAIISLDHYTLIPDPLLPKQKQSKSLIFCLQSNDESKYDWPDYFLQADSEEEKQIWIDCLQKLATGSSTSVLDKWLQRLDTPMTTSKIYQESNNSVPSLSQKTKNSNNNNDDDDYDEKSSIASSILLTPPNHIYSRSFLKNHKSFESLRAFKQMQERHIKRRPSDISCTKSDSSSKNEVFFLYYFYAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH25</accession>
    <name>A0A367JH25_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_005668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001332">
        <property type="protein sequence ID" value="RCH89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH25"/>
    <dbReference type="STRING" id="86630.A0A367JH25"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="458" mass="52244" checksum="F278243C77B79231" modified="2018-11-07" version="1">MPNLSEYEKKRLENIKANEELLKTLDIPTLGIKRRKIETKTTTSNKKKSPAAKKEPQQPTRVSARLRGKSPEKNVEETRTEREGPKTIESLDEQEHEKLLTLMKRALIPNIEPTIKTEDDVNDKALADQLKELKIKHDWTTVKVTPNRINGCAFHPSNAKLLGCAIDVEGYLGFWDIEGQDEDGEPVVYNYRPHTRTATDIKFDPFDQTKLITSSYDGLVKIFDMNKAEFETLDLGSDHFPITSFDIQQDGQLIWFSTSDGEVACVDKRKGGNPKIYTLREKKIGCIHINPIHQDLLAAGSNDRTTTVWDKRKLKKDPLQSFDHGYAVTSCYWSPNGDILATTSYDDYIRLFELSKDKKELNLKSAIPHNNHTGRWVTNFRARWNYNKYHGLEHQHFVIGNMGQTVDIYSGMNGKELIQLYDEDHITAIPSVIQFHPSTADPTLLTGNASGRMVCWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHF0</accession>
    <name>A0A367JHF0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">VPS17</name>
        <name evidence="2" type="ORF">CU097_001625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001313">
        <property type="protein sequence ID" value="RCH89305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHF0"/>
    <dbReference type="STRING" id="86630.A0A367JHF0"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="382" mass="45098" checksum="5FA818960EEC64D4" modified="2018-11-07" version="1">MSRCLQFSITHVDYKRKDPVFWIDVDTTITKFKQKQKRIPRYYSELQKLHSQLVSTLDDVWIPALPACPIPRFDKGGNLLPRQWWLTIKLSNESKDITVERSDPPEYRVQLWMNRIAKHERVQQSEILREFVESEVGFRPTLRVHKLSKPLLTYVSEQDMDPEFTFWTNQLSIVLHQLHQWLIQNNKFVQEHKAMSDGWINLSSSFVSFGAIERNPGLFISYKSLAKAYQQLYDIQRSQALVVYETVISEISCQIKNTEAAQNAMQRRLIALSEYISSRKHTESCLRQVERLKSSINIDRERANEAITLLENAKINERGSLQHYERIDGHLREDIEFRYKPNLSKDIKRALREYATGQLYLEKKKLMIWQELLNENKAIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHT1</accession>
    <name>A0A367JHT1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001289">
        <property type="protein sequence ID" value="RCH89429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHT1"/>
    <dbReference type="STRING" id="86630.A0A367JHT1"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="324" mass="37602" checksum="4C73AA6B0A25351C" modified="2018-11-07" version="1">MSTDQSLTWDKNLCEFFKEIGLIETSECLRSELVILSRSHLEKLPDELEKLVTRLIECLERHAQAKEDILEKPEKEHKDLLIRKRKHSETNEEEEQERMKRMESEQVQIRATAKEVDQRVNTFIQGKRNELDESNRTEFLNRINPSAEDVTCARTDAREINRNIQMKFDIVNNEDGPLARSTMTVGNKHTENHTATAADPTERINNMEQHLNIRLDHNAKPPFSIFERVKILENTLMEIEREHPRWAAVHFNQPNRTFPPPPPITYITRPPSQDGYTSTKINTAPPQPRMLKATGRANSSLTRAVVEQLNRQQQLSDAMSDSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI59</accession>
    <name>A0A367JI59_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001255">
        <property type="protein sequence ID" value="RCH89623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI59"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="53" mass="6224" checksum="8A31DD1CE4AEBA8A" modified="2018-11-07" version="1" fragment="single">MKEIHFAKYKKDEPATKKQKKSTEKDKKPSEKDKKSTEKDKKPSEKDKKKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIZ4</accession>
    <name>A0A367JIZ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAD2 mitotic arrest deficient-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MAD2L2</name>
        <name evidence="4" type="ORF">CU097_007667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001216">
        <property type="protein sequence ID" value="RCH89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIZ4"/>
    <dbReference type="STRING" id="86630.A0A367JIZ4"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016719113" evidence="2">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="131"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="38805" checksum="5B06E525308B44C4" modified="2018-11-07" version="1">MKSYVYIVCLLTLAWSAVCNPLSALKYSSAESATSLLSLQAVDEDMNNMQIVKTFLAENAQNDAVDIIYPTNNEVWHVNQQVSVIFREANYEPDETVSIYFFNLTPVLAGGPLNQRVFTFTVPASAYTGPDNTATLVAVKLEVWFHQILYYRNLYPRKVFEQRKKFQAPVYIAIHPEIQKYISQFVQSCYPLLEKGDIRCINLTVKNEKDDSIIEKVVFEINSVLKHVDIPLSKMYESESTCTLDDIEHHLRACLLKLNAIPSLLNNPAFSENRTFSLSIETTEGGYPVLSHDKQQDVDWVPAEVDTTSKRIIPIKSASMDIFRFNTFIMESSIKGKERCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ28</accession>
    <name>A0A367JJ28_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSM27_2</name>
        <name evidence="8" type="ORF">CU097_011520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001202">
        <property type="protein sequence ID" value="RCH89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ28"/>
    <dbReference type="STRING" id="86630.A0A367JJ28"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="101" mass="11460" checksum="C38A90DF61F8EE25" modified="2018-11-07" version="1">MSTARLSELKQLSCKIFSTVYNPTCARTGNKILRQRLLGPTLTGYHPKPLVHFRDIQALYPQLGLIDMDEKARLDEIARRKRRGKGAPKKGQGKRASNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ95</accession>
    <name>A0A367JJ95_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001230">
        <property type="protein sequence ID" value="RCH89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ95"/>
    <dbReference type="STRING" id="86630.A0A367JJ95"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="450"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="530" mass="62062" checksum="2ACED6E7E32D9313" modified="2018-11-07" version="1">MYRRNPTRALSIDDILQLQSLLAYEQDERAKHIEECQNSSNVVHLHHIYRSASPAEIAAAARSEKQRLEQALYNLRLLKEEYRRHRTRQIQAYLDEYRRQALIRAVLQEEEERYYRQCIAAALEQHRVNETWNRYVQMNAQQQEIERQLDEAYRTGYSEYRAQQLAELLTHLFEQQYQEKDKEYKQVEEEDDEKSNNDEAVAEVWKFLSDQKQDSETPRSAFLTSEHDALEENQSTPEASLSHEASEEEDGYEDEVEEDKTPEDVAPDTSHTQRTLPPLADHVVTLKDLVNQLASRPVLIGEQYTPAPGKAFYCDEPKPSGIWEKDQPKKTEKPKVEIPEVKKPYLPEHVFTEAEPTPTSERMSVSPVDEEEKEERENQRFVDEIAAEQQKETKSKDPQESKAIQQLNEISKSLESETSDIVSRWHHVLNQPLTFSKQKEGTLLLTATTDANRAYLGSEDELMRVMLKLDTIESNGNESIRSYRRELVQKCQSMLDQLDLHKQAELQKALSASKRQKRRKRRHHRSQRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJN9</accession>
    <name>A0A367JJN9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endoplasmic reticulum retention protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ERD2</name>
        <name evidence="12" type="ORF">CU097_012384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001167">
        <property type="protein sequence ID" value="RCH90164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJN9"/>
    <dbReference type="STRING" id="86630.A0A367JJN9"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH90164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="192" mass="22432" checksum="0E9D972FD631C9D8" modified="2018-11-07" version="1" fragment="single">IKKTRSCVGISFKTQLLYAIVFVTRYLDLFTKFISLYNTSMKIFFIASSVYILYLMHIKFKATYDAGLDTFRIEYLLGIASLLGLATTADYSIIEVLWTFSIWLESAAILPQLFMLQKTGEAETITTHYIFALGAYRALYILNWIYRYYVENHIEWVTCIAGLVQTAIYSDFFYIYYTKVLKGRKFELPKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJY5</accession>
    <name>A0A367JJY5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001157">
        <property type="protein sequence ID" value="RCH90216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJY5"/>
    <dbReference type="STRING" id="86630.A0A367JJY5"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="377"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="417" mass="47270" checksum="3039F5CDED7260A3" modified="2018-11-07" version="1">MPSFKNKQKKIYKKSKRLGSLRRKGIREYTGGYVHSDSDQEQSLEQHNTNEEVFIVSDEAKLCSSAPVTREQLTTATFSQCVTANPTLDLEDTESLGFFIDSNITSSSTDIKPIYYNDTPAIKSTGNKPTNKASKKDKKRKIIKDESIYLGSSDDDDDHISISSSEDIEILSALSHWAEIDMRQKERSEDEIEDIDMLNAVLFEDVCTNQVESDDEDIDLDEDDVFDLDQVPDALRASYMRMIHQERNEIKKEYERAKRQQQSRRPKMKKQSFMDHVLKELIQKSDVESLHLYHTTPYGRTSVIPKIAKIFRLETESEGTTVLLRKTANSLTSLKEYTGKKKNKKPVMMKPKAQKKSTKNDLIHGKVVASDAQPISSNNIGHRMLSAMGWKEGDSIGGGIKEPIKAVVRAKRRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKN4</accession>
    <name>A0A367JKN4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_005044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001122">
        <property type="protein sequence ID" value="RCH90429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKN4"/>
    <dbReference type="STRING" id="86630.A0A367JKN4"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH90429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="389" mass="44895" checksum="41D8D55AF9AF727D" modified="2018-11-07" version="1">MSEQPHIFTCISCQVAFQSPESQRAHYRTDWHRYNLKRKVVNLPPVTFSQFNEKAEAREAKEAEEKKAIETRNNYCTSCRKSFGSTNQYDNHMQSKKHKDNVAKQASALPKKSNDQPKQSKTIDMRVTEETTEEEMMAIIDEKIKSAPRLEETDCLFCTHRADTFEDNMSHMTSVHSLFIPDIEYLVDLRGLIRYLGEKITVGNVCIFCNGKGRGMRSVEAVRKHMIDKGHCKIAYEDDDDAAELVDFYDFSSSYPQPEEGEEVDVDAELTQLAQGLTLADDEMSLVLPNGSVVGHRHLKRYYDQKLKPEETRDSVLINKLIGQYSDSPAFESMRRNNSKQPLLLTDSRNRQGLRTSEAFKDLRRQHEYTTRVGINANKLQKYFRIQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL40</accession>
    <name>A0A367JL40_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stress-responsive transcription factor hsf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HSF1_3</name>
        <name evidence="8" type="ORF">CU097_011288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001097">
        <property type="protein sequence ID" value="RCH90605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL40"/>
    <dbReference type="STRING" id="86630.A0A367JL40"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="410" mass="47485" checksum="987870FE2102F8E7" modified="2018-11-07" version="1">MDPELHYMSIDSCIPYYNNLCNNNNNTPSTLSSQSETEVYKSSSMILNHGLINGTIFPTVVHDHPERGIAGFVSKLYQCLQDNEHNYARWCKHNGIDMFIIDCIPEFTEIVLPKLFKHCKFASFVRQLNIYGFQRDTDARKSKDGRDRDSCRWYHPYFKPGRRDLFHLIRRKPPRYSRGKRRRPENDVDTVLNVSEDEVLVNNENERRNSVSSVSSSSVTLHSTAPQQISREGSQDTRLPQDLFMSSSSSSILTPTSTIQPELYYTYTKPGYDLALYNQSLLQEEYEIYPIYLQQDYVQMYDTLATNHNNNNTYGLFQTQHINLLEPPYPPYPSTIENNLTTHLSVESSRLTPQLTDMINPVTPLCTLEHYPYFTTTNNNNSMPMPSQNYSNPSMYSSPSFEKTNDFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLI9</accession>
    <name>A0A367JLI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001066">
        <property type="protein sequence ID" value="RCH90798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLI9"/>
    <dbReference type="STRING" id="86630.A0A367JLI9"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="328" mass="37723" checksum="6061CDBF0D609ECB" modified="2018-11-07" version="1">MRLNPVSTYTIPVHPATEGFDVQKLAVEKHEFPAPAPATQKIAFLFSHSNGFHKESLHPLIRRLKDNLRAMKEYEHTDIHIFAWDARGHGDSARLNDGITVPTYRWFDNALDTKQVIDKMKLKKYDQLIGVGHSFGATSMILVEFFFPHTFDGLCVVEPVMSRLFYPMEVKLRSPILSSGKRRDEWQNREECKASLLKRKFWKVFDPEVLDLYVDYGMYDTDKGTIKLKCPKEHEYVEQSSYDTFTAYNSLKIITIPIHFVYALDSDFVAPEDTHTVADQNPAKITVQHIEGTHMVVNEKPDLIIPQIMALIDRVNQENKNGKGQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMG7</accession>
    <name>A0A367JMG7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001027">
        <property type="protein sequence ID" value="RCH91059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMG7"/>
    <dbReference type="STRING" id="86630.A0A367JMG7"/>
    <dbReference type="OrthoDB" id="10375968at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="21331" checksum="10064834716776ED" modified="2018-11-07" version="1">MLAIIDYQPKIPKEDFASVFENYCRSVSVHSSLLSPDTIDQQQHLPRSVSSGSLPRSSNNKSSSLYSLIQHLKWSIADFKKSPNSGKTKATSTDRLRLPSKVAHSSPMARIHHRSSGVDMPLGYENMLSGSSSSSSNASSVDLIQATSDIFLSLSQHISLSSLDSDSTIDIDSITTPLAYPDSNDSMAIRLSNKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMK2</accession>
    <name>A0A367JMK2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_005379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001016">
        <property type="protein sequence ID" value="RCH91125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMK2"/>
    <dbReference type="STRING" id="86630.A0A367JMK2"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="225"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="463" mass="53775" checksum="A1A680F1C0E5E4AC" modified="2018-11-07" version="1">MLNGPSRPKENHLRPTMMGNDKTALYQLSASLNTVKARDPKRLNGSLKRDRDTTTVTTITPSPQTSSILFGDPLPRIKEWRPKLSLRSVPIHQHKRIRLDPQYTQPEIELETHEIMYQGFEPRTLLLEPNYELQRVHARGVFVMLAKRNIQPTFIFRLPEHAWVKDLSGLRKTASFEMKTQEGEVWELHIKPSRDTAEYRGYMFGFLIRQIDMVRNVKDCVHELVRHRKLPLVLDLDDTLVRLVGNENGRFVPEADIPKCEDRVAVLKDGKRVVLTERVREFLEWAQQLFDISVCSLGDQNYVENVIDVLDPNRVWIKGILYSARAEHDYIRTSPEPGRPPKDLQALYSFCALRDQSLGSGFALPLILDDETRMWPAEQHDNIIEVKGQLNSEVWTVSLFPVVQETLLYVHTEFFRQYDTWYARSQDAEHQGLVYPKPPPSAISIYKTYLRHILRDMIAAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN38</accession>
    <name>A0A367JN38_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000988">
        <property type="protein sequence ID" value="RCH91305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN38"/>
    <dbReference type="STRING" id="86630.A0A367JN38"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="607" mass="68447" checksum="B00DC641ED6F84D3" modified="2018-11-07" version="1">MSDITKVDVLVSGAGPTGLFITYLLARQGHSVYCLDPKPGPTDQSRAILLTSRTMEILESKGLAGEFLAEGFVSSGIRMYRKGAVFGHIDALGDTPFPHMTIVMQSKTEEILTRHIKDETDCTVHWSTEFVSYTQDDEKVVSVVLDKTTGQEHKVESRFIVGADGSHSRVRKGNPEFTYEGIAVTTKFFLADLSIHGENIENMMDRMNTFMFESHVMGMIRIYSRREGKDDSHVFRIFGNVEAYNRSEEETTKPTHGLQKEEPPNLEEIQAFVDKVTAPLKFTLSDLIWSSYFRINERITNKYRIKRAFLAGDAAHCHSPAGGQGMNLGLQDADNLAWKLSLVLKGQAADPETLLDSYHIEREPHAASTIKMTSRATQAGITEGFLARNIREAAMSTMVMIPQVREYSFKNVMQLFVTVDGGSKLLGTSDKGLIKAGHFLPDSEGLRQRTLEKRTSLIRRLNLHEILIGTTQYTAILVATCPSQTKPRLDLLEKFWIHARPYPVKRIIVESSWHTHFNQYPLFVLPQEEQDAQTSFYSEERMDSPYSITSRVGLLPLFPKYFDGPSPCVLVIVRPDLYVAQSKTVYNENDLVSALEYFKTHLLSKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN54</accession>
    <name>A0A367JN54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SDH2_2</name>
        <name evidence="21" type="ORF">CU097_010815</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="PJQL01000989">
        <property type="protein sequence ID" value="RCH91299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN54"/>
    <dbReference type="STRING" id="86630.A0A367JN54"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH91299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="31733" checksum="ECB9F0734A26F379" modified="2018-11-07" version="1">MSIALQTLKTSINKRWVPVAAPLARSFNTSSSNMMASADTKQPNYKTFEIYRWNPDQPTEKPELKTYKVDLNSCGPMILDALIKIKNEQDSTLTFRRSCREGICGSCAMNIEGGNTLACISKIDRDTSKTTKIYPLPHMNIVKDLVPDLTHFYKQYKSIEPYLKQKTPVTDGKENLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEEYLGPAVLMQAYRWMIDSRDQFGAERREKLQNKMSLYRCHTIMNCSKTCPKGLQPGTAIAKIKLMMATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN82</accession>
    <name>A0A367JN82_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000977">
        <property type="protein sequence ID" value="RCH91378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN82"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="91" mass="10724" checksum="0BD69678D25453CC" modified="2018-11-07" version="1">MTSIEYKKTFGNRQRSSSFNHSVTNKKYSTRRPSYDILSTKKSIQFLNIEQPTAYSASSIDESNSDLEEDEDDDTQNITDYYLYRDEEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQR3</accession>
    <name>A0A367JQR3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000886">
        <property type="protein sequence ID" value="RCH92031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQR3"/>
    <dbReference type="STRING" id="86630.A0A367JQR3"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01309">
        <property type="entry name" value="Met_dep_hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="440"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="950" mass="103178" checksum="2345112FDD7E3FF8" modified="2018-11-07" version="1">MSSNQGYSSIPRNDEEGGGSSSDPLLPSHTKSSWPERADGFKQFVKRNLAYIVIIFIVAVLLGIVLFSSLLPESSLLPKGHQPFTVKSGVSEITMQHGREKCEAIKNRRREKNRPDPSRVKNPRADPNQKPILLKNAVVWDGQGNVLEDVDIYIESGVIRQVEKNISLDSNRDVKVIDVAGHVVSPGLVDMHSHMGVDSWPELHATDDTNEMTQPLTPFVRTIDAFNPSDNAIRIVSSGGVTTALVLPGSGNLMGGEAFAFKLRHISTLSNEDMLVQANVDSTEDTKWRWMKMACGENPKRFYGNAGYMPSTRLGEAYLFRKQFAEAQKLMREQDDWCRAADDTSSRFDTPFPEDLSLESLVALLRGEVLLNVHCYETHDIEAMIRHSLEFNFTISAFHHALDAYRIPGILRRARNNITVATFADHWGYKKEAFQAIPQAPKILYDAGIPVALKSDHPVLNSQHLAFEAAKSTHYGLPPQEAFKTVTSTPANAIGLGHRVGSLKVGYDADVVIWDREPLELGATPLQVFIDGVPLFEERPIEPAVKKQTTAVTVKKEDLQSVENTKNFVLKNVGYSFLGQEPVKGPIDVVVVDGSVICSGTDCSASISSIQSNEPVVEYNIQGGYVLPGLVGVGSQLGLIEIQGEAGTGDGTGRPSKSKDPKDIIFAADGIKLGTRHLEEAYKGGILTAITAPMSSNVVIGVSAAFKTGADSILNDGTIISPAVALHLQIGDDVKSDSFPTISSQISFIRQLLTENLKENNHYGQAARGEIPTVIAAHNKDEIASLVILKRKHLPKAKFVIIGGTEAYLVAPHLAEADIPVILRPVLCTPSRFDSIHCLTGAPLTNGTAAHVLHSHGVKIGVGISDDGLARNLAWDAGWLAATSPAHNLEGGAITETQAIQFITSNIRDIYGLNSISVNQANDFIVYSGNPFDIQSRIVLIHSDKGLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRQ5</accession>
    <name>A0A367JRQ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DOA4_2</name>
        <name evidence="9" type="ORF">CU097_008304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01000800">
        <property type="protein sequence ID" value="RCH92640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRQ5"/>
    <dbReference type="STRING" id="86630.A0A367JRQ5"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="573"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="929" mass="105449" checksum="B136CC34C882CE17" modified="2018-11-07" version="1">MSASYNVEYNNQMPSLPQFASSVAELQRRAFVDRSKIETYSIKSWISSAEKLYQQGDVALLVNDLEDAYVAYMKGSTIMIEIVRLHSSYLKIKTDPLYAQLRKRTDNEIVVILRDLASKIDFWYSYQQQLGQMSSFYYHSHVPLQLPSYAYNNELYNYSMNDLSSAVARQNIMAHANITSPNVSQRSSPLRQAPITVSSSNSTPIKSGNGMTALTHDISKLTLSNNVSIIPSWTNHTFPESTTIEPLDLSSRIQVRQHTPTILLIDVRSRDTFTSGCIQHKWIVQIEPSVLGKDTTARQIEESLVVNPSIERSLFIKRDRFDLIVYYDQHSKTIETADAPLKHLRRVLESHQLKHPPMMLAGGFDAWQFVIGERGIYKFPVIKEKKSWFKSTTSISSVSTTGSSSNSVYDYFTGKKEQQHKVNLPISKPQPLPTAPRKESITTRYPEMMTMKTESPNAMLSSPTDSIQMQPTVDLRPAPPTYAKLHRRRTFIDNPFNGFTTTSSKLYDVPPMQIHSDSNNLAHKAITSSVEPSITVSRPSTLGEFHHTSTSNLHSTPSNVISQQGGLIAIGTTGLKNLGNTCYMNSIIQCLSGTLPFARYFISGVFRQHINRHNTMGTGGLLSERFADLLRAMWSENYNFVSPMTFREAVIKFAPRFGGNDQHDSQEFLTVLLDGLHEDVNLAAVPSNMSRITEMTREEEAEFEKLPDWQASALAWEKYTSRHTSIVVSLFQGQYRSRLTCLTCKHTSSTYSPFMSLSLPIPAKKLKLSNVTLYQCLDYFVKEEVLEKEDAWNCPRCCKKRKATKQLMISKLPDVLLIHLKRFSADGLFKNKLDCIVKYPTKGLDLHNYITRSTQPDQTCYDRSLSVYDLYAVSNHYGSLSGGHYTAFVKDGHRNQWHFFDDSKFSTIDESKIVTKAAYNLFYVRSKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRZ5</accession>
    <name>A0A367JRZ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000803">
        <property type="protein sequence ID" value="RCH92619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRZ5"/>
    <dbReference type="STRING" id="86630.A0A367JRZ5"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7875" checksum="FC9548A41BB3DBC9" modified="2018-11-07" version="1" fragment="single">VVGLENIGPAIGLLYTTNIFGYLFGTPIASALINLDTPPNYLYGALWAGSTIVVGSLFAGWLRILKGGFKFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSJ1</accession>
    <name>A0A367JSJ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000762">
        <property type="protein sequence ID" value="RCH92924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSJ1"/>
    <dbReference type="OrthoDB" id="2264734at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07812">
        <property type="entry name" value="SRPBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24681" checksum="9845C8639E3F798D" modified="2018-11-07" version="1">MPFVTAAIVIFIIIPSIPLFAYVIGLLVPASHIVSRTRTIKTTPSRLWAILTDVSNYPEWQPKVEKVDIQNREEDRVTFIEYSVKKRHTVIIHHVRSSERCLLRVLEENMNHYNKIPTFSGSWTFEITPQEDNDTQVLLKITEQGVMKKPIVRLMHLLLYGFHSRIDRFMNDLSTKIERENKDNEQESSQETVNSIDHDWDLVSEAYPKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTG7</accession>
    <name>A0A367JTG7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000756">
        <property type="protein sequence ID" value="RCH92981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTG7"/>
    <dbReference type="STRING" id="86630.A0A367JTG7"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF1">
        <property type="entry name" value="QUEUOSINE SALVAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="39924" checksum="9B77A8122B3DDAFF" modified="2018-11-07" version="1">MEAVDKTATLPTGNFVEAVRTSCRALTEKSDKVKISKQGIDRFLSELDKKQYEELSYDSSVILPLKFSTMEEELNFISVINLLNFGSGYRLELHKYAGRGAFDTIRYGVMAMHIGGIPMDAKTFSEIDIFKVSEIFQFPIDQEVRHETLDFVTMSQPTPLKPLAVGITSTLNTTGKYLQDHGYKSLAQFILDHAKKQPKDALYLVEALVRAFPALHDHYVFGDDKVYLFKKAQIMVYHLWFLLRHQVPDLFDFTNINSLTVFADNVVPTMLIHLGVMEIADEWKEMIEKNVDLSVEVTTTLRAASVAACEDIVQASNGLMNTGGLDVYLWQLGKVGDYRKIPRLQLKDTIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUF5</accession>
    <name>A0A367JUF5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000677">
        <property type="protein sequence ID" value="RCH93604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUF5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="96" mass="10710" checksum="D4940510A4282235" modified="2018-11-07" version="1" fragment="single">TQEAVDLKLPASSDELKELLKTNNKVVVLFASYGVLICIAVEAFIYQFVQMILLMNTMVTDFPTVMHFKNHAKAGEVVGCSAPYIYDKATHEDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVM7</accession>
    <name>A0A367JVM7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000626">
        <property type="protein sequence ID" value="RCH94034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVM7"/>
    <dbReference type="STRING" id="86630.A0A367JVM7"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57769" checksum="A851122592163172" modified="2018-11-07" version="1">MNVDQSTMNQADVKESGIQKHIRYWDKKNKGYITPIDAIHGFMSLGYSVIFSVALGTVAGVFLSFLSQTSWLPDPFCRSFVNNLVRFKKQTSGAYDQNGVFDPEKFEELYHKYATSDDYITFAQFIKMTNEQEKLGSSVRSWMIGFIELCTAYFFIGDHGSLAKEDVRAAYDGTLFYRLEDNSTVQRKQKTVRSPPPLAGRYLLSSRKRAMRFIKGGLHSLSSSVSITNPIVRDWAAYLQENTIDIRNNSIYRILKRSSSPMIQGVTTPKPEAIFGNKKNIIVEEEEKQGDTFSHLTGVVQPENPLEDSTSPLRGLCIDDFTSSNDDSTIFRNMTKTNEEIDIYVINSSDEGLMGGFLRTDNDTDWLQEGFTGIKKDDRLVEVVSEKMHDFTNDENKKHATENQEEDQQQQEDHAESSVEHVTIAERELVVEPTVEYTVEQSEEHEKVTITPPPDEVSEKKDIPKATVITQEKKNHEPVQGKRTNNKKKKKKHNQAGHVSPITSDSGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY23</accession>
    <name>A0A367JY23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000535">
        <property type="protein sequence ID" value="RCH94830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY23"/>
    <dbReference type="OrthoDB" id="2251862at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="201" mass="22871" checksum="E7A047A0A72756C9" modified="2018-11-07" version="1">MLTHTSKEQRQTPNNAQWCLSHASSLSLNSSALQIDLCEYQCCMARYRAILDKYFDNDAKGSLLAKLKRWTLSMDCTDFWKKQVLEKMISDTHAPCTTLVDLIIIEETPYLTAETNLASDTTSTSNTNTVQLDINEDKNIRSDQNNVSYKNSANVDQHDNTNLNNKTDSLEGEEKRKFRGSMDVKFVDAVSLLFHAHMMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYQ4</accession>
    <name>A0A367JYQ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000511">
        <property type="protein sequence ID" value="RCH95029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYQ4"/>
    <dbReference type="STRING" id="86630.A0A367JYQ4"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="329" mass="37793" checksum="2B361B15BE3A3F6F" modified="2018-11-07" version="1">MTHQDLQQILYPQLSANTFETSTTVETVDDTDELNETPVVPATTETTVRVTRPLPPIDFILPRALSSERELLDLAFRPAALNTRVTCRIQRCRDGLDKLYPQYHLFIEHLLTGEMQHVMTARKKRKSNTSYYTITGVYQENSQVAEENVELGKVRSNFLGTTFVIYSHGKNPLKREMAGKKKDLPIREELGAVLYDPNILGFKGPRKMTILMHTLTRDGKRPEFRPTKESEMLLSKYKEGGARDLLILHNKSPQWNEETQSFVLNFNGRVTQASVKNFQIVHDNDLDYIVMQFGRVERDSFTMDYKYPMCLLQAFSIALTSFDAKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZD8</accession>
    <name>A0A367JZD8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial fusion and transport protein ugo1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000480">
        <property type="protein sequence ID" value="RCH95303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZD8"/>
    <dbReference type="STRING" id="86630.A0A367JZD8"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53929" checksum="787E01DC10056686" modified="2018-11-07" version="1">MQSNQNQPFTPFSPLGKNGVRPYYAPGLGAGNYTNIAVDQPGAPYYTVDYPDDLIDSRAAARELINFTVLKFLTTAVNSPFEVSKTLLQVQYMPREDLPVAKRTTTVQEGESDIEDEAGPYSEEDEEEDEEDEEEEHSGRRRHPSATDDPLTTGSSLNIDDPIFKKKVPLNADGYIVRTSVYDDSTRPPHQIKPIDGGVWQGIGRLLHHPHEGVRSLFKGQFTNWLYEISHLFLQPTLEGTLNDMFDLYDDTVPLVHLDSVGPNLATLVASNLIVGILLSPLELIKTRMIVQSASPLQRKYKGPFHALATIWKEEGGFKGLYFSHNFLPTVLYHTITPLFQNITPLIIDRVLCISASESPFLYSLAELGLNTLEILITLPLDTIRKRMQCQIRTRTPGNKRFEPVVALRPVPYTGVINAVYCIAKEEGGPRKKSRKENRYTNWNIRSLYRGFTMECTSNIVLFFLHAISGVEDDYEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZS1</accession>
    <name>A0A367JZS1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Pre-mRNA-splicing factor cef1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CEF1_2</name>
        <name evidence="16" type="ORF">CU097_014008</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000472">
        <property type="protein sequence ID" value="RCH95395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZS1"/>
    <dbReference type="STRING" id="86630.A0A367JZS1"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000091">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="14">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="14">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="15">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH95395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="721" mass="82748" checksum="A2B5879261C7733D" modified="2018-11-07" version="1">MKYIVKGGIWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWFEWLDPSIKKTEWSKEEDEKLLHLAKLMPTQWRTIAPIVGRTPAQCLERYQKLLDEAETRDTDRSKELGLQGAFGHETGPSADDVRKLRPGEVDPEPETKPARPDPVDMDEDEKEMLSEARARLANTQGKKAKRKARERQLEEARRLTALQKRRELKAAGIYMRLKTKPNVMDYNTDIPFEKKPALGFYDTTEEGSRTVDPGKLTNVHLSKLNRRRADIEEEKNREKKRKARENNNKGGPQGNQGQFVPEKNAKIQKMQEEEQIAKRRKLVLPAPQVGEQELEEIVKSGFAGENAKTLVADDVGATPFTDRGPTPLYSELRTPRPKTQIDGYPGATPLQSMATPRNAKPPQSVKVSLLQGLASLPKPRNEWEIRLPEIEQEDEKKPAEKAVEDMSDLEREIKEQAERDEQERAARRSLAVQLELPRPTTMHQFKADSNASEAEKMIYEELNRLLKHDAVKYPVAGGKVAPGAVQLPESIAQLEDEFDSKALADARKELDQEIVKTLGLSEDDDVKKAVWEHVSSKPEFEELWKKEHEELIFSVKFNRFLTLNEMDDDKDIIQGLEKTIEANRQTMIRDATRAGKLENKLEVRLGGYMNRSKMLSKQIVEAFEEYEAAQLEYNSFLNLQNAERAVIPRRIEALEYEVNKLVNREKELQERYKNLSDEKMELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZW4</accession>
    <name>A0A367JZW4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermatoproteinsis associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPATA5_2</name>
        <name evidence="5" type="ORF">CU097_013732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000465">
        <property type="protein sequence ID" value="RCH95460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZW4"/>
    <dbReference type="STRING" id="86630.A0A367JZW4"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001921">
        <property type="entry name" value="AAA ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="293"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="503" mass="55946" checksum="F707078363831E52" modified="2018-11-07" version="1">MQWVENVTAEIGGLRDLIKDIVSKISANKIDPCSTLPRSKGIILHGKPGVGKTALAISISKHSGQPYYMLNSSDIFSTGLTLICLVFYAKLHAFRGRNEIDIISGRASTRKSKLDIRIFSVLLHLIDQLGKNGFIIGTTSRLHAIDPVFIRSGRLDMVVEIATKLPQQRYEILQIITKSLPFESVDERNTILRQVSKVTHGFTPSDLQSVCSQVIFQLIRQQTEQKNQTAKLHHFMQALTVIRPSSLNEFGSRVPSVTFSDLYGLNDVIQELRACVIEPFHHPERYIQLGIMPPKGILLHGPTGVGKTMLCSALASEAGVNFMLVESSQIRSKIVGESEKAIAKLFAQARANSPCILFIDQIDMLLPKRGTSQSTENTSDRIVTSFLTEMDGLLTKTLDNNNAQIDLLVIAATNRIETMDPAVLRPGRFDERIHIPLPDSTQRLQIIKGISSKMPISLNDQEINELVQQTDKWSGAQLDNLFREAAMVSLRENVNNTEQAKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZZ3</accession>
    <name>A0A367JZZ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-protein transferase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDC20_2</name>
        <name evidence="10" type="ORF">CU097_012575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000465">
        <property type="protein sequence ID" value="RCH95459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZZ3"/>
    <dbReference type="STRING" id="86630.A0A367JZZ3"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="247"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="568" mass="62620" checksum="86F1F0EF82F7C069" modified="2018-11-07" version="1">MSSNTPEPSNEGTERKQDVSAGRPVLSRSCSSAPTYSSPSASKKTLLDEKPITKMPLTGPNPNQKTKDNNKQTTQASSSSKSTTSQNPRTLTDFLMRSKTSHSAGSSSSSSQAFQPPSLKRSYSAISSLDTANEHWLNTPIAPKQKRIDTKEVYDRLTPGIADMHSAQVLMSKTQPTSYFDIVGSKSYQEQVANACGIYPDKRILRYGPAPPPTAKVDITKNTQPTLNTSTSSSVKRHIITSPEKILDAPYMTDDYYLNVLDWSCHNVVAVGLGKSVYLWSADNGTIQALNYDYDDPVASLSYSADGAYLAVGTTKGDTQIWDVQANKKLRSMKGQDCRVGVLSWDKHIISSGARDGSIFSHDVRLAKHVVRELYGHADEVCGLKWRWDGELLASGGNDNTVNIWDARTTTPKYTKRTHVSAVKALAWCPWNRSILATGGGRDDKKIHFWNTTTCARLNTIHAGSQVTSLHWSQHYKEIVSTHGLPHNQVTVWGYPTLNKIIDIPAHETRILHSALSPDGQVLATAAADENLKFWRIFESNGKAPLASESARLTEKKEIQLRRSKSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0A8</accession>
    <name>A0A367K0A8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="13" type="primary">PSD1_1</name>
        <name evidence="12" type="synonym">PSD1</name>
        <name evidence="13" type="ORF">CU097_009678</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000447">
        <property type="protein sequence ID" value="RCH95633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0A8"/>
    <dbReference type="STRING" id="86630.A0A367K0A8"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023531747" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023531746" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="76"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="431"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH95633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="467" mass="52358" checksum="46C834DD89CA5B05" modified="2018-11-07" version="1">MGLHSLLRSSTRHVRSCNIRQRSFHASFVAKEQRPKQQKNTFGRVVDSWNNTQVKWYPIPVALGLAVIGAIQYRHIQQRVEKEDTQKPKYRATGPWQVHVAAALPLRSMSRLWGAFNSLTIPTPLRPAGFKLYSWIFGCNLEEMKNPNLYDYPNLSTFFYRELKEGVRPIAADAPLVSPADGKVLHFGIVQGKHIEQIKGVTYNLDALLGNDEPPASPVEHAVLGNVEQLVVDEKEFANVNGIAYTLDDMLAEKDDHQAVRMESSVGEDAVAEGYQAKPKEERALAQLASVDSGMTLKPNHALYFCVIYLAPGDYHRFHSPTNWVVETRRHFAGELFSVSPYFVKLLQNLFVLNERVALLGKWKHGFFSMIPVGATNVGSIKINFDEALQTNRKEDLPLGTYTEVTYKSASKLLGGKPLRYGDEMGGFYLGSTVVLVFEAPTSFKFCITSGQKIKMGEALGKYEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0S1</accession>
    <name>A0A367K0S1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000434">
        <property type="protein sequence ID" value="RCH95768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0S1"/>
    <dbReference type="STRING" id="86630.A0A367K0S1"/>
    <dbReference type="OrthoDB" id="2277387at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="32024" checksum="DEF22A401CD8405E" modified="2018-11-07" version="1">MDPEEITQTLGHHQLDIKSNNLERRTSLKPIDNRTPHLDVKSSISTPLKHTVDAQERIQFLREMEKTREELAEFKRNVNALIEQMDGISIDLELSKDRVSEIEQDLTATEEVNVNLQVLLEKAVKSQKESDVCATQTIRNMYTELASVVYENNQLQSRLASLESHQREQVGNVYDITRRMQEYTHMLEQAQGTIHMLQEPRHIKMSLSSTASSSRRTSTASFTEDDDEFATRKETHMTNRTYIQSPPLGPQQSSLFKPQQGLRMLLQSQGGSGLGSLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1Y7</accession>
    <name>A0A367K1Y7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000421">
        <property type="protein sequence ID" value="RCH95901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1Y7"/>
    <dbReference type="OrthoDB" id="10306124at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="516" mass="58476" checksum="E36CCFAB61E63DBE" modified="2018-11-07" version="1">MRNNLSFSFDEYTNNDSDSNKMQRNTGYNYNLLPSTTSNNESFVNNTNRQGTTIQTTEPDQSNRIDQTSTVQDNSPETVSWSLSKIVQQYGSQPEILELILLSKIEEDRRRAEEAKLKQKELDYLISNGSICSSSSNIGEDTAYTNNNSRSRLSDPTDALAFYHARFNDGMRRQSSDTVLHTKKDYFSLSQTRQLHFPDSAKKKHKNDIYPQTSPYASVNHNLQLQPLEQLNIARRYSQGGSSSLYRRPLSFSEQSSSQTKVHTRSSRSSSNSSSSSSSNALNISSSLFNPTYTQAFPSDFRQEKALAATESIKAMDKMPDNNNQELAIINSNMLPIDLKGKQVEGHRREQSSHSQLSETQHAVNSLSIAEQPFVEKSETHPEAVNTSHELLHGSTSLATNNAIDVHRHLKLPLPPHPQANQTTIDLLSRTRRKKREMQPITMIIETREFPYKDQYEWKNNGNTVNKNSGRRSIYYKCSNSKLGCSVNKTVTFKENGEYLIKYRGNHIDACKKANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2W4</accession>
    <name>A0A367K2W4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-zipper-like transcriptional regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000365">
        <property type="protein sequence ID" value="RCH96475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2W4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20262" checksum="C9E5B64EB80DB9C9" modified="2018-11-07" version="1">MNLHWKNVPLNNLDPERRVNPQFIVLSDNRRLFIDSGYAMHLINHTIVFDSYDNTWQKLPDFSGEKQRTDGRAVAVSLDTGDTVIIFGSETVKVFPMVIGNKTVESHVGLPLLNCTIYHTSSQIWAYLSRQINAPLDKIPYEHSATFHPSSGIIYYFGGRNCDSKDYATVASFRWGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3V8</accession>
    <name>A0A367K3V8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000334">
        <property type="protein sequence ID" value="RCH96825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3V8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="14358" checksum="CD7AC7F1265843B3" modified="2018-11-07" version="1">MTISEFYGHRYSKRYLFKDKSIRIICALHLTALGLHVSLAQYSVFLPANILELEEVVYKQESEISIVRYMFSLELPRRRFYRPLVAGISKQPFVLYRAIFMHTKKEVAAIGISEDALFFDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K476</accession>
    <name>A0A367K476_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000316">
        <property type="protein sequence ID" value="RCH97013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K476"/>
    <dbReference type="STRING" id="86630.A0A367K476"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052835">
        <property type="entry name" value="Nepro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761:SF1">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="34093" checksum="2CD5563E3B9FF236" modified="2018-11-07" version="1">MTPPPYYTLLDPPVPTKSVLSDVRINKSIKINHQQELEKLKGFLDSFKDQKLFWIEVTLIDRLYYKNVNQQRPFHRFKRSMEIRKLVKRLKALAIEKELERLYLSFWNAKTLDKCTGKWTFIPSKESIQYTMHRLIGAALILDKLKIVLVETYRANSTLLKLEHFVSLALVFMGICSRMYSLSQAWISQIEGCYQQLYSWSEAFPTGLKQKEYDLFVSTHNLACTRDTMKEARSTFAEQWMTLKSSIHHKTHLETYLANQAVVDKVKEIQKEIGVKSADPLSFDLEEDLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K486</accession>
    <name>A0A367K486_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000346">
        <property type="protein sequence ID" value="RCH96681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K486"/>
    <dbReference type="OrthoDB" id="2272691at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="444" mass="51097" checksum="BC9606E523C04855" modified="2018-11-07" version="1">MSQSQRTFVFRNTFAASVSSLDIDEQTTHERSVTPTNNNGSTNREETNTTPLAGSSTQSTPTSAEADAYKQTMLNGRDSQVTFATALSKGMISHPHWTVSETKSLIEAVTRFYSRMVQARTNNMLGSVWEDVLYEFNLGKPFRRSRRACQDKWHQLVKQYKDADEQRARDGSCSFLYYDEMHRVLSRETPAVNPMFTSFSIGHQEQQQQQQQQESPQPVQEQHQRSPQPHQLPPQTQQLLPQMQQSPTQQLPPQQLPPQQQPHQQPHQPQTSQPPPPLQQHQQQQHQHQQEQASQGAPLTHLQQNRQIQPPNAPPVQQEHQQIPTTTLQASRIINNTSLPPEQSVQPISSRLTQQQAVPNVIYNHDDSTRPDMVEGRPIIKKRRTNTTEELLENLLLKQEELISVIREQTELQRQFQVQKRQQHQELISLLTHLVDKIPSDEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K599</accession>
    <name>A0A367K599_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000314">
        <property type="protein sequence ID" value="RCH97031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K599"/>
    <dbReference type="STRING" id="86630.A0A367K599"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH97031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="765" mass="87579" checksum="7778D5B823C155D8" modified="2018-11-07" version="1">MAKGKSVRIKSEEDECQLMPDMVPLVSPPSATHLSRRTSTDDPSSITIEMQQEDPYFYDKNTRPPHESWSSAKTIENPFGDDISKQNTLVSSNMNEKQEISNSTTVTGDEDSDREFDWNDDPDQVKPKRRKTARERFQAAMRNPCCWHYLSPLLKRIIIAIFGSCMFIIVAIVIYFTLPKPTDAEQQNPLFKNVRSNVQCWMYWAAFMWHIFWITTFTLDSVPSIVSLWIKTFRGRRSERAKSYMEYYMSLKRYLCLVLLAAWNIGSWVFLINVPFPSIKLHPYSDVITKAFGCLLAASALFLGQKTVIQVIAVRFHRTAFEDRLIENKKSLKILDTLSKAEKKNRPVSGPGRVNRGNNKLRHRRSPQWDSDQGSRRPVTLSDAPVPHQPSSFDIFKKSISNIVLAEKPTSDVSGRLEKNKMDINSDDYAKKVAKKLFYSLAYPDGHLPGHDEDTKLKLEIHHFIPYFKDHEEAKEAFKVFDKDGNGNLTRREFRDTVVQIYRERKGLAQAIRDTSQALGKIDATLLVISCLITLFVSLSIFRVDFWAALIPFGTLLAACTFIFDTSAKALCQGIIFQFVTHPYDAGDLVMIDNAYMTVENIGILGTVFVGGDGSKLYAPTTLLLTKIITNVRRSGNMGETLTFNIDFRTDNDTIHLLRERLSEWVQSQSRDFAPGFDLRVSQIIDMNQIILTAWLPHKGNWVELGKRFQRKTRFMLALKSILTELDIKYELPAQRITSTNQNPFDMSQPPKPQNFGEQESHRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5N8</accession>
    <name>A0A367K5N8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_006384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000302">
        <property type="protein sequence ID" value="RCH97161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5N8"/>
    <dbReference type="STRING" id="86630.A0A367K5N8"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH97161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="12251" checksum="AE81878F8137B2BD" modified="2018-11-07" version="1">MPTKLQPRARPRKTPKMTETRLKRLEEYNNYLRSQLNISRITVSEASASLIDYCNNNKDPLLPSIWGPVPKNEDPFAPPESGQCCTIIIIEYSINIIYGWSIWINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6A9</accession>
    <name>A0A367K6A9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serum paraoxonase/arylesterase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the paraoxonase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000251">
        <property type="protein sequence ID" value="RCH97754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6A9"/>
    <dbReference type="STRING" id="86630.A0A367K6A9"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="In form B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44481" checksum="17B172C2B1BBB338" modified="2018-11-07" version="1">MPPAPKTYWFHFKYWGAIIPIAIIASFLYKTILILGIFNEIKDFNTESCEKITGPKDFMNCEDIILSDEPGVIYASCDPVRSYYNNIMGVNKLVPGQPVENGAIWKVDYNQQPADIKKLDMSPLQDYHPLGISLYIDPVSGEKTLLTINLSHNELPSVEIFTVQQDELVHKRTIRHPELYSPNSVHILQDDRFRSQDGTPSFFFSNDHYYSSPLLKQAETFLFPKTNVMFYNARTNQTQKVIDRLAFSNGVTGTDDVLFVSETSAGKVRQYKINRKTDKQGLPYVSLDFERETRVNGSPDNLHYYPEKEILAIATHPKPIEFYKMVTAPDINKAPKSPSEIDIWDISTGETRMILQDDGSLYGTSSTGIIDIKHSKLIVSGVFEEGVLVCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6C0</accession>
    <name>A0A367K6C0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000250">
        <property type="protein sequence ID" value="RCH97764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6C0"/>
    <dbReference type="STRING" id="86630.A0A367K6C0"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32085" checksum="023FF08D791B3DA8" modified="2018-11-07" version="1">MEPLSWLIILSAAMFIGSYIAGSLPLAVQLSQKKVHLLSSFGGGMLIGTCLVVVIPEGVEAIYKSTLQVNNTGQQHPQKRDPSVGSDGHAAMGIALIVGFALMFIIDQLNSQVTKPSMNGQEYSELEVISGERERERDSEQHRHDTSTASVTGLLIHAAADGIALGASVTRPELSVIVFLAIILHKAPAAFGLTSLLLNSGLTKTSIQKYLILFALAAPTGSILTYLILGLFSSNVTSTDIEYFSGLLLVFSGGTFLFVAMHALQEASHSKPSEVHRPTQLLITLVGMLIPTTLNIMHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA44</accession>
    <name>A0A367KA44_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000154">
        <property type="protein sequence ID" value="RCH98999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA44"/>
    <dbReference type="OrthoDB" id="2242749at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="342" mass="38536" checksum="02BC05727A23A66A" modified="2018-11-07" version="1">MTCQSLEWLTEEIYNGVGSSSSTIDCNSVITQEPNKFDGSESLEKILHFSSKLSSDKIGYLGILDLGSGTVISMLKKQLTEKDYDDIIQYATLTNVELTEYAEELITSLCGSKLATISLRNTMYKIGYRQGFNLVLNHDSGFVETTVCHFPHNPLIQTTGERAACIHTNIYIIEQLFLANNNVVVLDWIENEYCQTSRCKWDGIIMKYIIEHMDPLRFISCRTSERNIKKCTNLIKSVVKPGVNASNILVNEQSLQSYGRQQIISSIDRNSNPRYTAESFLVDPSDTENGAQFWEPRTFYQALGTSRMCAGLADVDVFHALLSYYRRLAGNRCLVSISSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAA1</accession>
    <name>A0A367KAA1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myb-like, SWIRM and MPN domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MYSM1_2</name>
        <name evidence="11" type="ORF">CU097_015233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000150">
        <property type="protein sequence ID" value="RCH99059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAA1"/>
    <dbReference type="STRING" id="86630.A0A367KAA1"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="253"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="458"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="641" mass="74007" checksum="8D9282440127FCE1" modified="2018-11-07" version="1">MHEEEEEIIDIGEDEKQELIDSSGNSNGSSQPTMMIEDQDMDKDSRQLIEQMLAEEEYYFFNKTTKNYDSDYPKKTKDISSAALPSHKTRWTKEEDDRLKEALDIFGYGNWKPIAEHVGTRNRLQCKNHARHLLLTPSKQKREESKEISKQTNTESETEIITADDADNTLPVNTTNTAGTATADVTMDATTMNEDGEDDLDIGDLVQDNSDKQLDDTTFMQNDDIKEEEDIAEQDEKEIKPDPLEREIDIPDNDTHVSISHFDRHFVSEEEKKQNPEWFQNKHAKTPDRYLRIRNHMLDCWNQCKPRYLTKTSARKGLKDCGDVNAIGRVHSYLESVGAINVDCITNAPRPPKRVPREVIVEEDTLDAASLVINYDGPRKRKVRNERGEWVDPRELEGRVIEHGVQVETDSNGTKSKRVKRSFHQHYYGGDDFNRGYDPFRLVPTSHYNELFPAPFEVEIVSDALLVMDFHAHLAHTEIIGLLGGNFIKKENAKILQVKSVFPCKSTSTGIQCEMDPESEMKAREVFAEQGYNVVGWYHSHPTFEPHPSIRDIENQTSYQTLFREAGDEPFIGVIVTPYNAEIQSDHSQFQYLHISTQWNETHSYRVPYACRRRVEQCEQVSPSILDQFKELIQEYKDYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAF2</accession>
    <name>A0A367KAF2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000144">
        <property type="protein sequence ID" value="RCH99130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAF2"/>
    <dbReference type="STRING" id="86630.A0A367KAF2"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13323" checksum="3A9A77AD962ECEF8" modified="2018-11-07" version="1">MSQSEQSTVDRQLKILSPPKNAPAIPEIPESAYKLDANELKMLYQSTLERREKLESRPLKTQKMRDAEDQERMKKYPKTTIRVRMPDYTIVQAVFQSKETGLYDCFVGGICTHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAL7</accession>
    <name>A0A367KAL7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KICSTOR complex protein szt2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000138">
        <property type="protein sequence ID" value="RCH99216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1857"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2449"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2607"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1867"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2463"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2485"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2616"/>
            <end position="2628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3280" mass="373835" checksum="C8ECF3906248FCCC" modified="2018-11-07" version="1">MSEQPSQHDSQTTKPTASKEQLKLIEAKTAVILLKTSKLCTKNEYTQWLLKMLYQPYSRQDTEQMNIIYLSRSRRRIWNPDFSINQEQSKGQTVNKNKDQLYVITPQTTLMTISQHNRIVYIVDLSSSLATIGDSQCNILLSEVYQTVFLQNAIITATNIPTILTRLRAEFIAFQEDIAAFRRFIREHRINMDYDLDVGSKTDPAPPDVLNATSFSLKGDINKGKPNELHVDAAIEKDKDTGYHSSKKEVWGVGKSGASLSRILHAGHFALKLLPREGSSHLVLITDGAMKSNIHDNTFVRQFAEEDINCHVIQVGSKSGFIPGKNFGFVPDTEVLKFLARATSGSFLYSEKCVPVASASREATEPLQENNQAVVQVVGINQLKQIVNPNIYHYHFLFREATFSKIGNEARLAENDSRMYLSRRNLDGEHIEWPLNFPWDPNAKSPEEECRLLKYKEYSLPSEFSHIVAARAREGFSIQSVTFDDGSGTRVLDPGIHELEAKNLSSVRKERVQMLMTMHWQPNVVIEYRIRATWLPVIIGNATSYNNETLLMSSGLFYRAKAPRAEILVRTDASFAHMLQNWDVFKRRAQMMGVVTGYIYFGETYAAPVYSKIEKLKNYLIDIYEGDETLRSIIGFPNKFWVNLTAAEPMTSPSRIDSPSYAARHVYMQHQEMYINSFKSIWNRMNAADTRARTRCWYDPECIDLLIGDVSPFMDPKLLSPYNQEFIYNAQENITAMLENVRTVLKEWADFEGDDGTLVKMLHRNLPTTITGHDDIIKEPFAPSPFKLSPSFCELRIRHEYGRLITLRLLFFNTEVSARRRVREHLLYLLKTSPLTAFPYNIVCQRPFSSLLMRDSKHFSDSYPNVQNGKTLGNMTKHQSRGRTWYLPFATWLTSEYIVRDYLHHITWTWQTNSYDDTYHRNNKMMPIHDLAFQFLCQTRLDQGYQLVSPRPDSTQFYQEITLPAATGNRTCRCAVQYFIWKDSATGKITTELWMEPAGEFDTSQYDRIKSWAFEPDRRKISELVTFDQIHAVGRSRGIGELREKRKNSQTVDGQEEKDNVMLLSQLFDVALVLRSNRFVIASFKSPVFEKSAHLQQIRLQLMLPQSSDKIPDGSSTTTANSPAVKNKSLIKTHRYFRRTANSSSADLVAHSSVPLEDQNSLLLKPDPLLLKSAKTIVKLSSVLQNYSILHYFVERSLEYVSNGEINMANHDLGTSFWNELKTALKKVCDYQKTSSTSLVSDLRKTRCFVKVFDPRSFVIILFPSLECASSSLLKLQTDDPSDELVSGPPISYHLDVFMFECTRQKPMKPVKETSTHGTPNLFSEEDLTDDLDNVTIQPIEYLIHEFDGVGRTLRPTFYRGYFSSCQSNAQLTERVLRVAQDIARSYSKSFFNSLYSCLLKGFLVDDNDLDKVLEVCNESSMEIDITEFVNIMALQDKDSAGLDVQMSEAQGKFNAIFNQYFQPVHTKNKSANLFYFKSLTNKYNTVFDFEDTSEDSKVFSLLNLAAHSRSPLLVKLFCVSRTIETDSADGRPRKVERSVPVNTLPTLDMDIFEKNSVLDGSTPDGFFTSKSEVLLQLVFLSMPKTELEKNDSKDNDILPAGIEKMLSSMKSQPECFSALNIEQQIALVETESRVRWLLREEALHGLLKVPSITPSVLTYVEQNLNKLNPYLGYETSITMPLYFVKNCAKGRLIFMNELEKDGYSSKRKYSLKRLGNYFYVSEDAMFNMGDESSYSNNGSPVTGDAPATADPGVQCDNFCDGLGITLLEATDPTKDKKTDEGKSNTSLSKRPLYWLILIPYERYVQIYYYSKMQILSTNSDVLNALKEKVKYIEERTNRIILLNHLQETRACSKYLEPPSITNETDSTSEESNEELTGDDLSDIQTHDGQRTPLSQEPHFSFGQFACPLLFTKRIPLHWRLQPNITLKILTSDVLRLFTVTNRPNMFVVERDGSIVYCKIFEEVVESNSHASPSTVCSSPGYTEKTKLVDDDARTVISLNGEQSIKRDLSMQTDAAIKKKASTNSRPAGIETRELVIQIFGVDLPNWVEAEFVNMIENRVLTQITLTEVQQFFARNTTSKPTLADVEFILPVCKAPTARDVLRVPSIVTDPILLLYCLNQITATDSIKPLQGPDVTEAIRFYHENVFYNEQRHAIRLASLDQSNSRSKDGLANTLCFYYNCTKRIPGSSTSLELLVGQGMAGICITLLDEAGEPVANSHTQAPNDDKFDPSLIPYCFEHSFREFNFEDTKYYLLIYIWSIGTVDSSVLIQHLYACYQQSLCDYFIEKTVTINIGSILTDQTGSSQTSAAKPKGRLRAALRSKFIDSMLYILKKSPQINNPTVLCMNKKIQASPWYISDLLRFLDAKLRKLDISFRPVVACTFLDKEPWDNTDSQSKPSNDWLLYKEHEYLSQSFRDNIRLVAISGLQEFVEKFENNSVQSRRLSVASTVDSQVSKSRRDSEDSVMTDNSSRQKNAKSIKQERSRASSTISNSTNAHKNGPQLDGRKHCFLMLNLDANNLSVYTYNWSQSFSTDLFKSIDSIINRQEARNDILTNILHQKMGLFHHTNSIKHTVEKYNAVIGNISKATNVSSSLLQNHSSSPVFKKPVQADHLNPKGPNQRTLENNGSPPANMLDLKDLIAFASKTQLEAHKHIEPSPSSIAARLKDQEAYVNMLLQKSPLKNAELERALMDSITDSVADGLLGKDTDVLRRHGQTFMEALMRRSKVQSAHRKALKVYIKWRNRYGNLNAEPEAAEKLTRQEVSTIIRSSRVLHFCRAPLIFCDPEKDWQSVSQGQATQAIVDWYVKMANSLIIEYAAYLEGADMQLLEFAKSEDDEAERVMKSSEFVVGKQLTASCSPVYLLSVFEGGSIICEVRLTGIFLSVTLYSLHRQYGRLDYRRFHPETRNKKRENFRKFEENCGRFKQLIHINSFVYDFHIRYFSRALEAPETLPSDLDIVFFMRRFSQSDHPPPPFCKDRLVHGMVHIKTSSVSLSTFFENLLKICTRSGWKSLLSRNSFLAASISCNNSSFNTLEESNRDSGEQWKYTLAISPGSKSMHIKRSNSHTEHDAVIEYFILVSNQEKLTPDSMARTSWYIKSNSSDKLEDMVVVKAADEQYSLIDVISGAKTKIDSISAEDWNKLYSANINKNTSSQKMEHPELIALLNQFERIDVTELDDGIASIFKLKLNWDNALNMITAMARNNAKDFYANGARHVLLYNARYMDFMIVLTLDPSKTIQGWLVTREKRAKQVGIRGPEQEQVVSLAKNLYYYIWRVVSNKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAT9</accession>
    <name>A0A367KAT9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATP9</name>
        <name evidence="10" type="ORF">CU097_015463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000133">
        <property type="protein sequence ID" value="RCH99286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAT9"/>
    <dbReference type="STRING" id="86630.A0A367KAT9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="9">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH99286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="88" mass="8977" checksum="2CE89C1331F956AD" modified="2018-11-07" version="1">MGEGHCVAPPSSGELEFKLLNLNSNSGVNSFRNLYIMVAAAKILGAGLATIGLAGAGVGVGLVFAALINSTSRNPSLRPQLFSYTILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAU3</accession>
    <name>A0A367KAU3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000128">
        <property type="protein sequence ID" value="RCH99363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAU3"/>
    <dbReference type="OrthoDB" id="2288700at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="23501" checksum="02A20B7DDFD49F72" modified="2018-11-07" version="1">MSAQGSPESVLIYYCPFLPNRPVPHVNKITKMGCSGQLMLEKKSTDYVLQLLGLYESNETPEQVKQKRFGTMPIETINFTSDCDMSPIKSTIKLIDFTDFKEAWTVIDEACALDRPDTLVCIVSLIQLKSSPSIIPQSYLMKGGTRLEEEEIDHSQSLIYSYLHPGSTRVDFIEHFGQDIIRTNNKILAWHFLAEIGNKLGYIAKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAV1</accession>
    <name>A0A367KAV1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000129">
        <property type="protein sequence ID" value="RCH99344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAV1"/>
    <dbReference type="OrthoDB" id="64113at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="139" mass="16462" checksum="0FA9F7877BA90053" modified="2018-11-07" version="1">MEQRIQQFHDDTKNIPKPPTAKTVKQMNTLKKFIFKNQDYRFSDKEKNKLFACIEAYFTVFDRSGLTGQVSSFPLIEDALKVPCFTTKQKSQLLKWYDEILAKQEGRDVPKKEDHNNNDEENYDDFDWDAFEKEGYTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAZ0</accession>
    <name>A0A367KAZ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase spindle elongation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000134">
        <property type="protein sequence ID" value="RCH99279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAZ0"/>
    <dbReference type="STRING" id="86630.A0A367KAZ0"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="61920" checksum="D5D9BCCD4AB4B0DE" modified="2018-11-07" version="1">MGEYAASTAVIDRNKSLRDNLQELQDELIKVKERYNESLIYVQELHKQLKALHTALGGFVNINLIATTEVDVSSLAVNSLEDELQHAEQEYARRKAIVDDTATEICNILVTLGIDSLNNKADKLVMQYHQETNPDKKIELCNNLVSEESIYYLTERIAQLKETQRQVEDRKEELTQKLKHLWDRLRIDPEECEVFLMANRGLTQEEIQNYEMELKRLLKIRQERIGDFIERAREELVSLWDQLYYTEDQRRQFHPAYSDETTDEILEAHESEISRLRLEVEDSKYILDRIEKYMKLKQEIEEFEASTRDPNRLFGKGQRDPGRLLREEKFRKRVERELPKISKELEGSLLEYEALKNRPFMVYGKPYLETIYDNKEAQQKAIAPRTPKRDTMPRKPFTSPRATTNKYAMFNTPQFNRTRSFQAVTETPKMDTSISILHRVRERNIRKRPQKPIRRGHFGSDDDDEEEEEEKAFTSFKSQTTHMNKQLPLKRKHMEPEFDSDDNLAVNLDIFDDGPDLSDMSDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBC9</accession>
    <name>A0A367KBC9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000121">
        <property type="protein sequence ID" value="RCH99478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBC9"/>
    <dbReference type="STRING" id="86630.A0A367KBC9"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="9103" checksum="16D30A94F8ECA75B" modified="2018-11-07" version="1" fragment="single">TAAGAKQQEALNYLEKKLKKNPELNMEDTIELAITTLSNVLAVDFKAAELEIGIVTKDNTDFRTLSTEEIDDHLQRIVEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBN5</accession>
    <name>A0A367KBN5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000110">
        <property type="protein sequence ID" value="RCH99625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBN5"/>
    <dbReference type="STRING" id="86630.A0A367KBN5"/>
    <dbReference type="OrthoDB" id="2288822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="263" mass="29485" checksum="42639EE002D7BC18" modified="2018-11-07" version="1">MENTNLDDITTNNQQRPRSASVQSSRSWPLLPVLQVTTTGSSSNDAHLNNRQTEVINEPIMEADSKNASSNSTTSDSETSLEYEDILEKELPRRHSCTRQLTGKKSMTASKKSDSAGTLVEAALEQPQARERHVRFGDHILEAGNLVERMLSTRIEDNVEPPSHNHHTHTIDEDSIYLRNGSIEDGRSPSSPTVGTGSVLASLMKLESQRRQAILTKQKNVKRKKVNRDSFNIFMLRTFFLVKKRPKEQNAEAKIPVQPTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC40</accession>
    <name>A0A367KC40_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_015474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000101">
        <property type="protein sequence ID" value="RCH99775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC40"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="85219" checksum="C758314DB8027A08" modified="2018-11-07" version="1">MSFQDGFNKEETAYSRNKKEDDEKSLKNKDLWLSNPKDIKTDDESGPSEEEHYFDSDETDVAIVNDIAVINDNPDLPVLTVRSIITGLILSILSSSVSQLMQFKPVGSTLTNTFLLIVAYLICSAWAKWLPQHAWLNPGPFNYKEHTCIYIMVSSANTSAYGTLVLSTQQLFYSNTPGPAGSIFFLLATQLVGYGIAGQLRPFLVYPSNLIWPTSLPLVSVLSTFSAKSEEARWRTRFFFIVFFAIFVYELIPQYMFPLLGGLSIVCIARQDSRWVKNLFGGLNPNEGLGMFSLCFDWNLLSSISPLVLPFWVQMNILAGILLLWFIGPLAYYFNVWNAQSFPFLSNSIFRLFPNGTAEYYPQGEVLNSDNTVNQTALAEVGIPVYSTIYAISYVVVNMTLTATISHVFLFYGKQIYDTFRILRTKLSTGDLDIHMKLMKNYPEVPQWWYYGVFMTGIAVNIGVAYANHSGFPWWGCILAIGLSAILSLPLNMITAITGGGIGLNVFAEMIGGFVLPGHPIANMYFKTLGYNTLSQAGAMASDLKIGHYMKVPPRMTFLYQMLGTTIGAIFNYIINKLIVESKADVLLLPNGNQFWNGAGPQTMNSAAMTWGGIGPMAMFGPHSRYSMVLWAFFIGFLLPVPFWALHKKYPKAGFQYVNIPMIASGYMIMPGSTTSWITCSYIIVIYSQFYLKRRYTAWFAKHNYLISAALDSGTSIMVFLLSMTVQGGGSGVPYPFPTWWGNRQDLAEAGLYPDMCCAKCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCC9</accession>
    <name>A0A367KCC9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000097">
        <property type="protein sequence ID" value="RCH99828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCC9"/>
    <dbReference type="STRING" id="86630.A0A367KCC9"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="17"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="394" mass="44530" checksum="9E76549396123A1B" modified="2018-11-07" version="1">MLYSQKLSQNARAKKDNVTYLNIMVVGMSEFGKTSFIRTFCEALKQDMIQGTYKESKHKALKGPVQLTEELYTISMQIEQDGKRIALTFIDTPGLTSSPTVADQLKYITKYVDHQFARTLAEESKVRRDAKALDTHIHACLYFMGTSCIQGLADVDRFILKVLSARTNVIPIIAKADTLTSAQTEKLKKTIKKDLFDTYRIPVYGYIEEENDGDDDGDDDDDDNSVSEEENSYLSRTINFLMECVEEDKDEDAHAMLEYLHAMPFTVIGYEEDPESGRPIQLLPGEANSQPSSAVSLTDPGYYSESIGSIGSSEISPNSSKSSIVSHGMGSTKHLLGRRYPWGVVDCYNPSHCDFLLIKKVLLKTHREMLRIDTFECFYEKYRTQQLMEKPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCH3</accession>
    <name>A0A367KCH3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein prenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000094">
        <property type="protein sequence ID" value="RCH99876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCH3"/>
    <dbReference type="STRING" id="86630.A0A367KCH3"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="843"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1148" mass="131586" checksum="B1B0008B423F0069" modified="2018-11-07" version="1">MESLKVKQSFIELDNARCNERWQDIPELAKKYKKHHPQESVLEFTARIESEFVLLLKQTREPILNNSLSTNDLRKESTVQLSQVMIKQLDEDYIHALDDPNNVKLSKRLTPSQAQLVLVRLLDMIQRQIKSGELETPDDWQAQFSKIILARIYFETGRYDKALEWLQQLALRLEDVESGYGLVQLVQARVIKGRCFEHLEKDVDALESYMLALSVVEEHPDEKNKALANWVEDCLYRSILLQLRRKGPVKQTLRLMRAYTNYCHTQWWPVHFRIHKRWIIFRHYIRYLTRAYQKGLYIPAGEDDSLTSPVTSPVKSTFSENSSTSASALEETILLVNEFRTLLNEFVKRSLSTEPVDINHKTLEICHLIVSAHDTVGWGPEEHIERILRFFYKARALTFNSPSISRHIFYLHLYLNQHDKATLALKSYLELLGLPDILKREDSLYHDEENEDHSLVEGMISTIQQQLQKVQTDSNDSVSQCLQAVEQKINSVLATYDEKSSDEDEFLPPAQSLLLDTMTTKRKVPPGACENDNEFDVVRVLLAGAQQIYSRLPQNNEGIILCDLAMALLEEAETLKKKKMNQWKSLMIQCRRARGCSYGLYASKHSEPERRLECFNEALVSLKRASELDSRSWQTFYELGLQQAIAGNMSQAISAVKRSIKLRGDFIPSWHLLALIQSSREFQDLPKALAIVHTAVTYNADIVNEDDEDVSNEFFERAIAFMKLKMSQMYILEAIEGHIPKGYMDLLNLFYKISKKLNLIVAPVSSNSKRPSVHVHSNSSSMVMNSRQNAGSYRISNHSSIYSNNSSSMSLYAMESVDSLYMLQNDNEEEKEDSKLALLKVEEVQEEEQEGEAEMQQQASEESVSRSTFGTPTSDKKRSRRSFSLSRSQLEDPLLSLPNIRKKKEKSTTTQKSRKSIISGLRAYRNSIGGSKEVTSEENSYASIHKNESSAKQTENSIVANQSTSVIQQPIEEEQSEKKIINLHPIDYQNRWKQILVNIWIMASQSYLKDKQYEDAVKAIEEADQLTNGESAQVWHQIGLIILAAEKGSCHKAIDAFKMALTIDSDHVPSTISLASVYLDINQYELAEQLLEKTTKGLGWNQPEAWYLLSKVYMKQESILDAKHCLLYALQLSETATIQPLDGFPRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE27</accession>
    <name>A0A367KE27_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Antiviral helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_006960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000058">
        <property type="protein sequence ID" value="RCI00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE27"/>
    <dbReference type="STRING" id="86630.A0A367KE27"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="316"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="601"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1248" mass="140520" checksum="5A1AD9B6C0AF2B97" modified="2018-11-07" version="1">MSNQLSDDKLFEIFSRLRSDEKQPLKLEKPTVEDIKKELEETFLTPQRTFPASWLSKCQEHWEEMPDYTNNVYSQLAKPRTTIHVARQGFDGDIIGYRESIIDDPNLTAINSTSFSRSFGSTKNFVRGSAAQFPFAPGGLEAEVIEEEDEGHVEVNVDADLFNLSGAGNIAPGLDRGLSFGDEEEQQEKEIEAISKKSTVFSIENMMDPLNSTFDFLDVKVKPVDGHVEEPVPTTKVEETSDVVGPQEVDELFPTSLPPQKELVPKKLTTASEALKRREWAHEINVNEPFENFHDLVPEMAMQFPFELDTFQKQAVYHLEMGDSVFIAAHTSAGKTVVADYAIALATKHMTKAIYTSPIKALSNQKFRDFKHTFGDDVGILTGDVQIKPEASCLVMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIMLPAHVNIILLSATVPNTREFAGWVGRTKKKDIYVISTLKRPVPLEHYLYANRDIYKIVAANENKISTIGYKKAQDAMTKRKEQIEKSSGNSNTRGGRGGRGGAVSRGGGKPIGRSYHAAMQTDRNLFVHLIGMLKTKSLLPVVIFTFSKKRCEEYASGLSKTDLCSNLEKSEIHVFIERSLVRLRGSDKHLPQILRMRELMSRGIAVHHGGLLPIMKEIVEILFARGLIKVLFATETFAMGVNMPARCVVFSSIRKHDGRNFRDLLPGEYTQMSGRAGRRGLDSTGVVIIATGGDEPPEASTLSTMILGKPTKLESQFRLTYNMILNLLRVEALKVEEMIKRSFSENSTQKLLPDTKRLVDENEQKKSALRQLDCAICEPDIERFYDVCGEVVYLNRTMITQFITATPVGNRALCMGRLVVINTNVYRNAPALILKPLPSSANSQHRSFYCLVLLDKNLDISDTPNLDETPPLPITEICTPEEGNSKTEIITVPAPDILFITRLSLKIDADAVMAGKDNNLDMVKAVQELQSFGADAKKGGIVEYDWGKIKDVEFQEMLRSKNSLIKKLRSEFQCIKCPELKEHYSLIHAHKRLSSQIEMLKMTISDQNLELLPDYHQRIEILRRLNYIDDQGTVQLKGRVACEINSADELLLTELVLDNVFADFEPAEVVAILSCFVFQERNASEPRLTPKLIKGKEIVLTYARKLAELQAECGLAISVEDYVASFRFELVEVVYEWARGLPFKHITDLTDVLEGSIVRCITRLDETCREVMGAARMVGDTSLYKKMEQAEQDIKRDIVFAASLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF13</accession>
    <name>A0A367KF13_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000039">
        <property type="protein sequence ID" value="RCI00814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF13"/>
    <dbReference type="OrthoDB" id="2254372at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="187" mass="21509" checksum="FB16887D877EA0D2" modified="2018-11-07" version="1">MSSLHLPSFNNKLKKKPSFILEKRPNLERSVSNSSTLSKVRRFGSKLIRSKSQRIISLPSSPQEVSPPFELNISPTFNRDSRFSLVASLNESTSSIEEYVKTPTTADFCQRSFNIGHPSDQEDEQEEEYDEEYDEEVDESTLSTVSLVRYHLSMALKQVDEEIEDELQTSHEIMLRNLKSCPRISFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFA2</accession>
    <name>A0A367KFA2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000039">
        <property type="protein sequence ID" value="RCI00800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFA2"/>
    <dbReference type="STRING" id="86630.A0A367KFA2"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF6">
        <property type="entry name" value="LETM1 RBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="144"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="38540" checksum="E9F1C0F5FF3D1307" modified="2018-11-07" version="1">MRRSFPVKRPLTAGYSFPSSRAAVIIKPLPRYQPVRHFSYGYVRYNQLQTENKSLLNETNEAVANQPTSRIGKLIQQSKELVKFYKDGIKLLWSNHKEAKALQLKVQNEGYELSRSEFQLIHRAQKDIIKLIPFGIIFCILPESIPLLVIYVPAMIPSTCLKDSQIQKQREKLDKVRQKMTMNVLKSAEQVQGIAPEDFLSLPKFQRIAKHYAYDFDLSRIDRRHLSAYCRFMGLNDYGTQGMLKKRLAKYMDYIEKDDKLLAKEGVDNLDIKELSTAVEERGMRSLNEPEEQMRRALKYWLAVTQNQQSGQIAIPPGLLVFSRMFLLNAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFT4</accession>
    <name>A0A367KFT4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase II subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KU80_2</name>
        <name evidence="17" type="ORF">CU097_007776</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000028">
        <property type="protein sequence ID" value="RCI01027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFT4"/>
    <dbReference type="STRING" id="86630.A0A367KFT4"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="16">
        <location>
            <begin position="297"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI01027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="746" mass="85187" checksum="FC1B14E257EDA434" modified="2018-11-07" version="1">MAQKRATVYILNVTESMSHYPENAFQKALDCITASLEDKILSGRKTDFTSILLAGTPNTDNVCADQLDTPDQYQNISTLYPLQQTTLNILRQLIKIRPVSDSSIKVDVLDAVIVAIQMILAHCKKLKYEKCIAVFSNAKDPIDWRDYHDIAAVLRDNNIVMLFNGVDYHEYKDPMCTKEIEMNYDFWIKLASQTPDGRVCHINETYEEINQIQVKEVRPTPSYRGYLYLGSPSKNHFLAISVFMYLRVKEVKMPSSKKYSSLSQGPTHDVVPEKIYTVSNTGESKTDGIDTTEEEDYITVSKDELEKAYRFGKQVVKVSPEEEEYGKLKTKKELSILEFVPASTFRRYYLKGHPYIVSAGSYCSEESAIAISALAHALHETDTLALVRYVYKDDGAPKLGVLFPLFEKDISLLHYVELPFSEDVHPYTFPSPPKDISDDTKGSQLIDELIDTMDLNKLTDIHGNKYLDPNDTFNPILWRVNKAIKARALDPNAAIPKLGKEFQIQYNTPDAFKESLMFTAAKLRDHFQIKKGMEKKRKYEQANEEASFKLTPIDELVQKNKQTKIQHPNGDVQNITINTPIDDFKAMSKEASDGHLPRLLAVEQLSKIVIELVTHSFGSQNYQKAIECLQVMRNTAAEEEEAKTFNATLNQLKGWCELSNKTSPRRQFWEMLKGNKLTLITQEESKDADVQHLTKNDALKFFDEEASSMEPMMLSTQEDAEDMFDVDDLVSFLYKHYQKAKYLVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFT6</accession>
    <name>A0A367KFT6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000026">
        <property type="protein sequence ID" value="RCI01075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFT6"/>
    <dbReference type="STRING" id="86630.A0A367KFT6"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="219"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="313" mass="36808" checksum="552587D41E4EB04C" modified="2018-11-07" version="1">MSPFLSKKQTSNAMDYLNKLTKNSEKFQQYTMSKFRYIVALEESRQELKEYTCEKAIENEQLNRYYNILPYDKNCVELKDRRLGKNDYINASFIVPPFNIPRYYIAAQGPLRHTIVDFWHTIVEYEVPLIVCLTPETEKELEKCARYWPDGEKELIVKEEEVMVKLKNVEKERLFEDADCIIRHISVEFYNQNELVKQTSVIQLQFLGWPDHGVPSKPHKLISLIKLARTYYKDRKPTLVHCSAGCGRTGTFCVIDSAEVLSKTNNITFDPVYCLTDEFRKQRTTMVQTQSQYNFCYTALKEFLKDTTSTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGS7</accession>
    <name>A0A367KGS7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TXNRD3</name>
        <name evidence="7" type="ORF">CU097_009540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000014">
        <property type="protein sequence ID" value="RCI01340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGS7"/>
    <dbReference type="STRING" id="86630.A0A367KGS7"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011900">
        <property type="entry name" value="GRX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02181">
        <property type="entry name" value="GRX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="6">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="12290" checksum="93EFEC423B4BA1D4" modified="2018-11-07" version="1">MGSSISQEEMTKVQDIVEEIIKTNKIVVFSKTYCPYCHRAKDVLKQHGVQFFVMELDVEELGSAIQQYLQEKTGQRTVPNIFINEQHIGGCDDLMKLNGSGELKKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKN5</accession>
    <name>A0A367IKN5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005329">
        <property type="protein sequence ID" value="RCH78230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKN5"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="141" mass="15773" checksum="EE7101CDF13BE504" modified="2018-11-07" version="1" fragment="single">MEDMYQYAAAATTADTAGSNNNNEENDVILKAFHNMGWGKKWSSLVDTVKKQVFLLTFLNHLELIRESLASINTVNFTSLKDGLMKALEQRLPSQVQSVHLPENMDLKQLKEGLARGTRSAEHYLQTFGTEVISALKNTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILQ3</accession>
    <name>A0A367ILQ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005033">
        <property type="protein sequence ID" value="RCH78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILQ3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="22195" checksum="4E055901906D1B4E" modified="2018-11-07" version="1" fragment="single">QKTQPVQQKVQPVQQKVQPVQQKVQPVQQQQTANSHAQSHSRSSQTRTPVSRSPSRNSTTTSKSPRISPSATSNNVSASSTASKTPSPSPRRSEDNGQHSARASFSNQHSNGFSETIRQSLKSKIGSFVRRSSNDALSKKARGNSTDSAASIGSKKSGSSSRKSSINQSITTSSSHGSQQSAKNVSEKDVSNSLASSTTESQRSRRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQP2</accession>
    <name>A0A367IQP2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PTC1_1</name>
        <name evidence="2" type="ORF">CU097_000743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004167">
        <property type="protein sequence ID" value="RCH79982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQP2"/>
    <dbReference type="STRING" id="86630.A0A367IQP2"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="52" mass="5886" checksum="9F026B518E35E1B6" modified="2018-11-07" version="1" fragment="single">LWDVCEDQDAVDLIKDIQDPQVASQKLLDHALANFSTDNLSVMVIRLDDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQT5</accession>
    <name>A0A367IQT5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FPR2_1</name>
        <name evidence="9" type="ORF">CU097_003077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="PJQL01004127">
        <property type="protein sequence ID" value="RCH80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQT5"/>
    <dbReference type="STRING" id="86630.A0A367IQT5"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016900173" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="195" mass="21918" checksum="0D6CC963FF3BDE4D" modified="2018-11-07" version="1">MLPSILYKLLLLSIAVVVVCASKSESELEQPTKLLGGTLKKPEKCKAKSATNSNVKIHYRARVWGQKEFFENTYLRHKPIDVQLGKNKIIKGIEDGVHGMCAGEIRRLLIPANLAYGEFGIPNLVPPNTAIVADVEMIYVDSPFSNPWFWVSGVILIVAFFFYRQNIKQSERSSPGAMLQAQLGQQQQEQEKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRA6</accession>
    <name>A0A367IRA6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004041">
        <property type="protein sequence ID" value="RCH80205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRA6"/>
    <dbReference type="OrthoDB" id="2438256at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9470" checksum="47FE5B86848A78DC" modified="2018-11-07" version="1" fragment="single">MAAMNDNVYARVRDKMREQNFSEQEIEALDNARGLLKTYARIGGFMGATAAFLIGKSKKFKPFPLLMVAGGGFFLGSQTGFLTGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUE2</accession>
    <name>A0A367IUE2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003494">
        <property type="protein sequence ID" value="RCH81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUE2"/>
    <dbReference type="OrthoDB" id="2269728at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="287" mass="32706" checksum="584C248A73AF4628" modified="2018-11-07" version="1">MSFHETRSRKSSDPYAGQYPPPPPLSQEDLSIEHNRHHEPFYLIDPSSHHSIPTTDHERRSSHHDTIHSHHTGGDYDDPDAVELREYLYAERQEKLRKKQQEQLQKEQQEQEEQEIEPVIHQQDMPSPILPSHPPVFYSNAPAHSLPSPILLPPPRIFNQHLPPVPLPQSGLIPSPFGISPFHPPPPPLMPIMGDQEKYNYVRNDGCCCGVSFCSCFWTLLLFILFLAGIALIIIATRYVSDICNNESILCGKTIYNGFLYGGIAIAGLAGLIVLWRIVRWSSHRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV63</accession>
    <name>A0A367IV63_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">VTS1_2</name>
        <name evidence="13" type="ORF">CU097_002040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003466">
        <property type="protein sequence ID" value="RCH81371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV63"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="333"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH81371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="45830" checksum="6A54EB0D42931135" modified="2018-11-07" version="1">MLPNDFSKPRTTRPMSEIINPGHFINEADIAGRWFEDLQRYENNLDEMASATLDQNFKEEMQHVDQWFRYLTEAEKTATMYTLLQHSTQVQARFFINLLQQMVKRDPLYSLLTPNHDSDHPLASAMAKAELEASQRLMSVLPYKTGVLRNTNNRHSFALGDTEDRLFGYSLLDDNNARRIQQQQQQQQQSLFTSSRPHSVIEGSDSLFVPKWNSNVRQRTNVVGPIGTERPKSADISQWNLPGQYSVWSQIQPPPTEDTFNRRTRINQQRTAATNNIPAVPETAEDYSMKNNASDDSRRRSSSATTTTTTAGKESNSNNNKKPSEVVDMELLKDVPAWLRSLRLHKYNPIFGDMRWQDMVKMSDQELLNKGVAALGARRKMLKVFENVKAHCEANDIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWL1</accession>
    <name>A0A367IWL1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01003172">
        <property type="protein sequence ID" value="RCH82042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWL1"/>
    <dbReference type="STRING" id="86630.A0A367IWL1"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH82042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="410" mass="47785" checksum="0815B3039C0D9EC0" modified="2018-11-07" version="1">MLKQIYSFAVITRVITISLALLTYYFLSSYDSSAEIQTRSSHNLLNAFLRWDALYFLHIAEHGYVYEQETAFFPVMPLISRFLTNTILLPLKYLFGYQHALLFSGVAVANISFILAAGALYKLTLTLLPRNPKLAFASSIAFCLSPPSMFMSSFYTESLFALLGFLGMRFVARKKYMYAASIWAIASGTRSNGILYCGFFFYDLVWIRLLKHKVMYNVYTGLIQSILYSLITCSGFILFQYFGYKQFCALDRPWCNNKLPLLYSFVQKEYWDVGFLSYYQVKQIPNFLLAAPITLISIYGLLSYIRFDWKRFVFLKTQENKDDDSFYSNRLLVYMYLWIFMLFYVLTSMHVQVIIRFFTSLPPFYWFVGHVWINGFEKKVNERTANVILGYFVLYGLTGVILFANFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWY6</accession>
    <name>A0A367IWY6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003119">
        <property type="protein sequence ID" value="RCH82172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWY6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="67" mass="7755" checksum="01D4806266339010" modified="2018-11-07" version="1">MLIKVDPTPPTGDIVKRHLTERFSKLPFDQVNLLKVLIFIDNKMSCLEIRSSKKSLTTTPEHKRFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX92</accession>
    <name>A0A367IX92_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003076">
        <property type="protein sequence ID" value="RCH82282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX92"/>
    <dbReference type="STRING" id="86630.A0A367IX92"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH82282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="19686" checksum="C72F80102023336D" modified="2018-11-07" version="1">MKSACTLPSLSDIVNTNGYFYTRQPTKPSILHVSSLLSPTRTDSVLYESDEPVKAKRKRASPSQLYILNRVFQQTCFPSTELRIELGKRLGMSPRTVQIWFQNKRQSTRTRERVTPQQQRRSMFVSPPVSPLPSPSLIKSLSLPPLHPPPAFALSPSSSAHSSPTSIDAMLFRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYL5</accession>
    <name>A0A367IYL5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DiGeorge syndrome critical region protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DGCR14_1</name>
        <name evidence="5" type="ORF">CU097_000853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002902">
        <property type="protein sequence ID" value="RCH82762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYL5"/>
    <dbReference type="STRING" id="86630.A0A367IYL5"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="29128" checksum="5EC74749060F3852" modified="2018-11-07" version="1" fragment="single">NKWFFDKESHQLRITNGTQSVQLIEGPTGWKYKARNALMYYPEGKSESWIKEDDARGQPKAIDYKNTDITIPLTTQEDKPPSDIATQQGKVTPWTQLSQVDQHATSDASPVLRGYQLVASTPALSPSRVGTPQMTWGSIEGTPMLVDGSATPGPKFSLPEISRREQLGMKLSEKASRAYRKKTSERVSKGTPRSGAGLMSPAAQHLLRKSQNSPHLQRTAFGDALRSAYGSSPLRTGSTVRRPGETPTPVPLFRAGATPLAKNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYY7</accession>
    <name>A0A367IYY7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002933">
        <property type="protein sequence ID" value="RCH82671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYY7"/>
    <dbReference type="OrthoDB" id="2267106at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9986" checksum="14B6271BA88F17CB" modified="2018-11-07" version="1">MTLNSTQHEELIESREETLKEINEALSLLKSIYEYEDNKDTTEESEDQDDWSDNEWEVIKAYFENEQEDEEERKLMLMCINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZX4</accession>
    <name>A0A367IZX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002728">
        <property type="protein sequence ID" value="RCH83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZX4"/>
    <dbReference type="STRING" id="86630.A0A367IZX4"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68808" checksum="9A291958727E7CB5" modified="2018-11-07" version="1" fragment="single">SPLDSSDEEEDDPKTAGNSRDTIMDLYDNHLNKHPEPSLGDSLANVTPQSVKILPQVPNVAQAKQATTMHPPNKGTTNVKSASPIKENASHPVKDAGHVQMTYIEAPTAKMGTLTISNTTIEVQRAVVPEIMQAVTQNTNEYLAMKDKMAQNTSAPAAARAALQQTVPRTSSMRNHAHKPLPQHPLPLPGQNHPPSNYNHNGQVHPNQSPRSAPSHAHPTPVQPRPSVPQNGNRPMYSSPMNTQKQQPNFRPQQNNSRPMNAPPSPNHQNFRPHNGAPSPYQQPARPYNGAPPHQQPARPQYSNTPNLGAPSPTLSNNMPRMPQGPSSSPRLQQPPGRFNAPSPSPSHAQMNNSSDEWNSPPHSPSAYITSNSIKQVLYSNNQCEVFHWNNQSWYAADGQCLLQVRLTHNNRTCMAVELQNTGQLYLNAWILPTTVIKQPSPTDISISVYMGTKKETYLVHFPQPQDATALVNILYKAHQESNQPLLPSPEPMVDHDDEIEPVDNVNCPQTLKPVMQCKAKLFVQNETNNWSTLGSVTMRISQQSPSMRMMIQIENDKAKLVSAIVRSGNVEKINSKRISFLLSDEAQKTSIVYMIHLREEQTGNKIYEYLRIKNAENGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J016</accession>
    <name>A0A367J016_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002717">
        <property type="protein sequence ID" value="RCH83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J016"/>
    <dbReference type="OrthoDB" id="2284518at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="293" mass="33457" checksum="08CD73063501A6BA" modified="2018-11-07" version="1">MIKNQSRSNLYDRVKSDLFDQDDLNNREDVYIPSITAMVLLQMQAYIVQSLVKSNTRSYLHQFIHWILLFALLILDNMARLLDVEHEIANLTHKKKRGQCVDNGKKKEELQEIVTITKPCHTIVSPSSSITSPTPTYVRQRKVSSPSAVHQTSPVLEPSRQHNTSSSPMGHVRSLSNNILDKKQHTLRRVTGQREITVQNTIAPIQKSHKHHSHHNHQRKTITPMSSTANSVASRSSSSESSLTKESSEYHNHHHNKPKMVQTRSLTTHDLTEQKSLDNRRPYGRCCPACEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0C8</accession>
    <name>A0A367J0C8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-5 sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ERG3_1</name>
        <name evidence="7" type="ORF">CU097_003763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002677">
        <property type="protein sequence ID" value="RCH83392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0C8"/>
    <dbReference type="STRING" id="86630.A0A367J0C8"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="140"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="306" mass="36487" checksum="27C32E787B52526B" modified="2018-11-07" version="1">MDTILYIADHYVFDTLYAKVWPSYTKTIAGHVVSSWPRDDFWRVNLSVYLITLAFGNILYLLTATFSYYFVFDHDYMKHPKFLKNQIKMEIECALSAMPWMTLFTLPFFVGEIYGKSLLYGGMPKTAYDWLYLIISIPSFLFFTDCGIYWFHRWMHHPRVYKYLHKLHHKWVIPTPFASHAFNPCDGFLQSLPYHLYAYMIPIHKYLYLGLFGFVNLWTVMIHDGEFISHSEIINTSAHHFVHHVYFNYNYGQYFTFWDRLGGSHRQPTEEQYDKALRDDHKVMARQAFDADEIEGETLGVKPKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0E5</accession>
    <name>A0A367J0E5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002670">
        <property type="protein sequence ID" value="RCH83413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0E5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7362" checksum="92BE50E7836FB89D" modified="2018-11-07" version="1">MDIGELENPYSYDKCGSKHSQTGTSGPLQIGDYDEKQNGCSKQQAKATEEHCDNKLREEPKEASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1L5</accession>
    <name>A0A367J1L5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002610">
        <property type="protein sequence ID" value="RCH83601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1L5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="232" mass="26234" checksum="FF0825BF302A2B81" modified="2018-11-07" version="1">MYANNESTSSASNDYESSDDHIKSLGEIARTLNENGEFIPEVYCSKEEIREALLGYEKKFNIVLMALTALWIENNLLRKDSKKAIKVAVAATLKVDTTILFLIQDLFTANTGFNQKKLNKELSNFEINLMQHIAERNKDKRDLSKPDIQAMFQEIALRADTKQSMEEAVSKMKEYFLKDGVCKTSKEKGKADPTGITIKSIKNEVKIGAVEGLADLTGYRLIQLVQRSDRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2H4</accession>
    <name>A0A367J2H4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002451">
        <property type="protein sequence ID" value="RCH84138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2H4"/>
    <dbReference type="STRING" id="86630.A0A367J2H4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14982" checksum="1FB7C52CD3B5E82D" modified="2018-11-07" version="1" fragment="single">FAEPDIKDQINPGPLIQKTQSTMTNMLLSRNMCPKIAVELNEKLAAAGFEDITVIEKELPMGHNEKKGELWWQDYKHTTQNLRPAMFMVNPELEDPEKFASFLDECRQECVANKTSFRWVVTYAQKYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2J4</accession>
    <name>A0A367J2J4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002473">
        <property type="protein sequence ID" value="RCH84059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2J4"/>
    <dbReference type="OrthoDB" id="2443300at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="141" mass="16253" checksum="D2D05C13AE92031B" modified="2018-11-07" version="1">MNEVQNDPKLPASKSTPQGVSAFKLLSLNGNGFFKVSKPSTRRQFIWHIRSCNPIFATLQEMDNSDNPFFQFDLLHQHPVYFDPSFSITRIPIPEDARCFLAQVTLINDFIEPFFILAIYTPANVARERHEFLKGFHSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J328</accession>
    <name>A0A367J328_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CCH1_1</name>
        <name evidence="20" type="ORF">CU097_000200</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002419">
        <property type="protein sequence ID" value="RCH84249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367J328"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1207"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1289"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1330"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1422"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1509"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="1553"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1583" mass="182941" checksum="F276B243938163A3" modified="2018-11-07" version="1" fragment="single">LPAIYKPASVDPEIDRKKVNRLIQYDRHKFFRDLVKAVRGVAERVVNLHQYAINHKAAVDENKELQERRQEQWQKYSEEDQESDASSVVDENIPMKRTATISNPDQVKDDSTSDVESFSYLSGNSLKLFSPQNPFRVFLYHALCWKWMETLIMFLIVFHTITLFIVGWGSDPFPNPPSTWGQVWYQYVLLVIFILYTIIAICRIIVLGLFFNPPSPQSPRAYLRHSWNRIDFISILSYWVDFILLMTHQEINEDQGRRILVFKMLSALVLLRLLNITDGSKVILNSLKRAAPLLVNVLFFVFFFFVIFAIIGVQSFSGSFQRHCVWHDPNNASHTEELQQYCGGYINETGYKVPYKLKSGQTALWSKGFICEQGLICEETENPYGGTISFDSIFSSMLIVMIITGVQSWTDRMYDMMDAEYVVAALYFIVIVIVMNFWLINLFIAVITEMFAKVREDSQHSAFTNATAKPILADMNEEGGWEFAENEEQEQQQKVSSLTWLVTFMRPFWIFLIAVDLVCMATKHNDMSTAQLDGLDLAETIFSLAFLVEMVLRLLAQRRDLKAFFKDKMNTTDLLIAVVTCIIQLPWIKQHRLIYIWFTGFQVLRIYRVIVAIPRLRNLMSRVVGSMYGLINLTFFIVLSTLLCAIIAYQLFEGVINETGEEMRFFSIYNSFAALYQLFSGEDWTTVLYNVLQAGSTNRNSAIYALFLVFWFCFSNFVLVNMFIAVLMENFEIAEEDKLKNQVLFFMKKTESELNRKTVVSRWNIYRYFKPQPKGLDLTNIPNHLVLSVQKNVVREFMNETTQEIAEERQVETTRHGMMSKAMNFISRLFPSPDLAHAQRPVLQTHARQSMHFDQVGTFYDLKGRGSTDEPRALRYLIDPTLRDTVANRYQQETTDLDIEERKALKRDFIAAHPSYDRALFIFSSNNPIRRFCQRIVPPSRGERTFGVPASRWISLSFSAFITACVVANVVLTIQNSPVYQYQHRNDPEKIMRFVYTDWAFTVVFSIEFVIKIIADGFVMTPNAYLLNGWNMLDLFVLVTLYMSNFDKFAGATGIERGFRAFKALRVLRLINLLGPAKDTFTAILFTGLPRLLESAALGLCLIVPFALYGKNVFMGLFYQCNDDSSTGKSDCLFENMLGTQEPMPEDTSIYLPRRWANPYDYNFDSFWRSLLILFEIASGEGWVDVMETSMGITGKDLSPEQDASQLWGIFFMVYNLAGSVFVISLFLGVVMENFTRRNGSAYLTSDQRRWLDLKKFLNQVRPAKRPKSPPTNKLRKWCFDLTVEKQGFFYKLMTVVVTLNIVFLCADNVSSSDPGSGDVTSWDNAKVDVYLTFIVIYWLEIIIKILGLGWSSFRKNLWNLYDMVMVFGGSVTTFIHYGSPGLQWNVELQKLFVTALCFKLVQRSDSLNQLFTTMAASTYQILNVMAVWFIVMTTYAIMFMQIFGLTKYGPSASNEHVNFRTFSSTMISLIRYSTGEGWNNVMHDFTVEYPNCVVSDNYLDSDCGSLRWAYFLFLSFNIISMYIFTSIFVAVVADNFSYVYQTRANFSLVNRDEIRKYKMTWASVDTDRTGYVKPSEYMTFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J345</accession>
    <name>A0A367J345_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002393">
        <property type="protein sequence ID" value="RCH84333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J345"/>
    <dbReference type="STRING" id="86630.A0A367J345"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="62" mass="6932" checksum="3595D5A83946A262" modified="2018-11-07" version="1">MTSSVEYYKIKAFRLTPVLKPGKTAYVAIDGEHAPCKPFQVQVHPRLCSVLAIKPTFLNTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4U2</accession>
    <name>A0A367J4U2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VMA13_2</name>
        <name evidence="7" type="ORF">CU097_006881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002245">
        <property type="protein sequence ID" value="RCH84869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4U2"/>
    <dbReference type="STRING" id="86630.A0A367J4U2"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="348"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="54207" checksum="82B9F19C6C376F45" modified="2018-11-07" version="1">MLTAIPPNIPPPQVETISPTLARDDLVEEVKLTIISHPYLDDTMNKIRQEPIPWEEYTNVGLISENEMAMIKHVENKSVEELEPIMTEHGRYYALLYLELMQKLARVDTLQKVLVLIHDMLSEHEERIYLFHEAKKDNPEFPFGPFHKVLSINDEFIGIQSSKLLTMLICSTPHRDINIHEFFRWITFQLQSRQQHIVDLNIQILDALFHVPEYRRAFWETPHAIDTLVSILKANKHSDPQKIYEITFAIWLLTFDEQVAKNLDKKCKIIPVLLDYAKSTPKEKVIRVIIATFKNLIEKAPTENMSAMLVAKLLPFIEHLATRKWSDQEIVDDIEYMKTELQQNFQSLSTFEVYASEVETGRLHWESPSHASENFWKQNANRLNEKDQHLLRLLARLLSTSTDFTVLAIACHDLGQYVKYSSDPNSKSYLQSIGAKQRIMELMTHQDAGVRYQALCATQKYFAMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5V4</accession>
    <name>A0A367J5V4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002183">
        <property type="protein sequence ID" value="RCH85101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5V4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="116" mass="13003" checksum="866DB6CBEE500A17" modified="2018-11-07" version="1">MIRLCFRSKDDAFFLANPNLEKESYHNHSLAENNLLYTASGRRSALIQNEATLANDIIVSMAPARNIQRAITGDDGLLHKLTVNDINNLHYESADGVSDKRPFKSANKLIQLMEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7W7</accession>
    <name>A0A367J7W7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ethanolamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001951">
        <property type="protein sequence ID" value="RCH86052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7W7"/>
    <dbReference type="STRING" id="86630.A0A367J7W7"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43121" checksum="5B4E3FA0E365EAB1" modified="2018-11-07" version="1">MLATTDIHNFNKLPTIPECSTIIDLTILKGDKLKNEVFKLVQTLFPEWANDAQDFQLSRVSGALTNAVFFVDASNRKRLLLRVYGIGVDQIIDRDNELAWIARLSHLNIGPSLLGVFGNGRFEQYLPSKTLTSAEIRIPDISKQIAACTRELHDIVTVYPPDRFSVMEVWNNVDKWYKLAVNVLPDLIKKSNTWAKALNDYDLKRLAHEIQECKQILASVNSPIVFAQNDSQYGNVLQLEKSHELVIVDFEYAGYNPRGYDIANHFCEWMYNYHSEQPAAMNKENYPTYEEQICFLTAYLETTSKFRASDMNKDVTPESLQKEVSMYVMASHLTWGLWGLIQANQSEIDFDFFLYSTQRLNAFREELAVWRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8C3</accession>
    <name>A0A367J8C3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UBE2S_2</name>
        <name evidence="10" type="ORF">CU097_009580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001926">
        <property type="protein sequence ID" value="RCH86166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8C3"/>
    <dbReference type="STRING" id="86630.A0A367J8C3"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH86166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="205" mass="23709" checksum="F3BDC37ECCF3FB50" modified="2018-11-07" version="1">MTLTAKAIKLIAKELEKLQSDPPEDIQVIANEESLTELHCWIRGPDKTPYEDGYFKIKLVFDENFPDSPPKGYFMTKIFHPNVSDKGEICVNTLKKDWKPELGIRHVLLAIKCLLIVPNPESALNEEAGKLLLEQYEDYAKRARLYTSIQAKSGKSQYLLLVEQRQKENQSDQQEASKTLSNQKRPLEEQDIKKKTVKKRLLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8N5</accession>
    <name>A0A367J8N5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_007835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001942">
        <property type="protein sequence ID" value="RCH86091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8N5"/>
    <dbReference type="STRING" id="86630.A0A367J8N5"/>
    <dbReference type="OrthoDB" id="2389483at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="27383" checksum="69611873A9A4D236" modified="2018-11-07" version="1">MNHFIKQEEEEGYTDFLHDHAPCQEGPLMIPEGEESYLAQSSLQLAHFINQIYDYQYHPSCYDYWLPHNPSLITTICIKPEHMTFPLPESNSTTVTSTATTTPVCCTPDPPKVEEKEAQKKKVNKKKETKKKRVKAYDSQTTAYLQSMFFETYSKQIKLTKQQRLEVQRKTGLPSRNITYWFSNHKRRFQGSLNVFKKVMENSNGAVATYDDFIKWRRNQGLPDNVTKEELQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J999</accession>
    <name>A0A367J999_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate 5-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">INP52_2</name>
        <name evidence="3" type="ORF">CU097_009778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001851">
        <property type="protein sequence ID" value="RCH86513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J999"/>
    <dbReference type="STRING" id="86630.A0A367J999"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="30649" checksum="3A4FD946B0F25A21" modified="2018-11-07" version="1" fragment="single">HFASGQANVEDRNNDFYTINEGLRFLRGRTIDSHDNIVWVSDLNYRVSLSNLEASRHAREYIHQGNIEALLHHDQLIREMNQGNVFPGYKEGLITFLPTYKYDVGTDIYDTSEKQRIPGWTDRILYKGGQLRQLQYSRAELYTSDHRPVFALFEADVITLDKEAKFKLQKEIYQSLSSIEVRQHPPELPKRKMTAPLPATKDPLVDVLIDISLDTPSQRLPPPSTDKRKWWEDGEGLPKADKTQVNTQNPFEEDLSNSHLTDGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9R5</accession>
    <name>A0A367J9R5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001840">
        <property type="protein sequence ID" value="RCH86569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9R5"/>
    <dbReference type="STRING" id="86630.A0A367J9R5"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="322" mass="36713" checksum="4D811A8C58C5EF52" modified="2018-11-07" version="1">MLRLFTRSTLRSCQRSLSTQVIDDVRGIMRKVPQPVVVVTTCKPEDPSYRRGITVASFTSVCLHPEPLVSFCVRVPSRASQLLHSSGSMVLNMLSHEQVQQSVVFSSPSADQFKDIPFFDDPMTGLPVLSGTVGAMHCEAYKVIELGDHEMWITKVIRVEEGVGGEHGVREEAKPLLYYDRGYRSVGDQVFMKAFTEDDGTLDTTKWTHRAHLRLAWNYIRELGPDAAEPVIKKTIQSHFKRDAKKSQSYNETITMFYIALVSAAMRSYKEYENDFFALVERYPELLDPKTIETYYSPKVLHTEKAKHEFVEPDLRPLPETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAA3</accession>
    <name>A0A367JAA3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001787">
        <property type="protein sequence ID" value="RCH86825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAA3"/>
    <dbReference type="OrthoDB" id="2286436at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="11667" checksum="1213E3FAFC1F951E" modified="2018-11-07" version="1">MSSHSNRTVEDSVLLYRLHTNEVQLRTLAVVLSLTGGLALSFAVGVGILIYWYAKRGNQKKPPSPPPSLPLPSPMPVCLSRLTPEPSAPPDTIDTLPPPPPYDRQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAT1</accession>
    <name>A0A367JAT1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001737">
        <property type="protein sequence ID" value="RCH87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAT1"/>
    <dbReference type="STRING" id="86630.A0A367JAT1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="139" mass="16008" checksum="60F4A553889C0FF4" modified="2018-11-07" version="1">MSRKLYSCKDCKKCFDSPSTLRTHQRTVHDTSETLPARSKTGQDKPYVCAYADCGKSFSQYGNLKTHARKHTGERPYQCSYEGCDKAFTQLGNLRTHEIIHWPVKPFMCTYPNCGKGFTQRGNLKTHQIKVHQMEDVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAT4</accession>
    <name>A0A367JAT4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001739">
        <property type="protein sequence ID" value="RCH87053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAT4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016885152" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="82" mass="9035" checksum="DF16A0CDAD4D16B1" modified="2018-11-07" version="1">MRSSFITLTFTAACLLGSSLARPIPDSITDLLIPVDWLWYALHSGLSSLENIHKIDRLPDQAFEDTPASDDSPKPDAPPTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBW5</accession>
    <name>A0A367JBW5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001655">
        <property type="protein sequence ID" value="RCH87452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBW5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13572" checksum="E2F88F5B6F1B2205" modified="2018-11-07" version="1">MTDKEESVKKRRVRCDSAETEMSDGFRDQDLVDTDLETADFFFPRPIEHEIQEEAEIGELFDIPKEEIDDSKDSISTSEKEKDNDDSDWITDNEEDEEAVNDKEEQDGFMMYRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCH7</accession>
    <name>A0A367JCH7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001627">
        <property type="protein sequence ID" value="RCH87585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCH7"/>
    <dbReference type="OrthoDB" id="2287221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="454" mass="51276" checksum="011EB29429F042B2" modified="2018-11-07" version="1">MSQCIINNYKAGSKDKYQQSWRKAFKDNSKRLEIKVVCDTYRGDIWKEMIAGELKASITDTRNSPFDNSTFSLQYQKILTEKDKPLMKHMYDKIGEKWCLKEGVVVEDVIYNETKGYSVEHPFHSYILHINDSKLVDMFKPEEIEEIEKESGKADLMKALPEPLANMLMNLNGKANSNSLFYLYSGILQANVLPTEATGSNSNQVRPDAIVCEIDQSSWGKSLGFGEVKLADVTPNLNELGQDLLRLATLSKNALLKSGLNASMSFQIHGYRMKIYMSMLIPGTGITAMLEVLSLEFPRSVLQLDAFVTRRNLDSLVHLHEMFWRNCLSKQEAKTAAAPNTLELSTLNAIRQSTRDRTRPNNIHAQHDRVIEYDDQDTAIQSLKSEIRSFKGALLSRRNFPTISTSPVTSNVPSPIVTTATEPPASIPDAYHPRRKRSFRSELPSSAQVEKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDQ3</accession>
    <name>A0A367JDQ3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNHIT6_1</name>
        <name evidence="16" type="ORF">CU097_010288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001579">
        <property type="protein sequence ID" value="RCH87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDQ3"/>
    <dbReference type="STRING" id="86630.A0A367JDQ3"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="276"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH87851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="43082" checksum="93B924D62DF23C70" modified="2018-11-07" version="1">MNSSLDPSVNGQTSKECEICHAEDWKYTCPRCLIHTCSVPCVKKHKLDTQCSGERDKTAYVPLKSYNESTMMNDYTYLEDVSRQSDNLTRARRELTSKNMKLKLRQLHKQANYLGIKYFSLPVGMTRNTKNQSNYNQKSRQIYWTIEVNFYRNNEKNHYLEHGFPGNRPFHDFFHNMLFSETPRGKDSFSIMRHELKYFIDAGLEQFRVALKKEKAPRGEFVDVTGILDMSFLDTLRGETVVEYPTFYVWLKDDPQPSEILSLEEKRVLIRPLKRSHEEVDHEKEQDEKRLKMDNEENKTDDTEEGELDEESKVDELEEEESKVDELEEEEEEEEEEEEESRIDELDELEEESSDVKDKENTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JES3</accession>
    <name>A0A367JES3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001506">
        <property type="protein sequence ID" value="RCH88231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JES3"/>
    <dbReference type="STRING" id="86630.A0A367JES3"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="322" mass="37073" checksum="7E2B8F4AC9DCD57A" modified="2018-11-07" version="1">MSWRSVDHLQHNPIIIIDPILDGTKDVGTKPLSSPVLVMPPATYDSPLLSTPSFSSSVSTLSSCQSAQTDFFDATLVQSQARQIEELRKDLTVLNEKYIWQIEKLQSAEQQTAEIEHELEDLSQHLFEQANAMHSKCTEFLDREWQRLFMEFIEATPRTPIDLLHRLPFLKSCTVMDTQPCLRSCSRLPKYIIKRLLDSAIHQPCLIETATSFQKQHQQLTGRSSFASIFRPGSSSQCYGCGSKIDKEGELYRFKLKEMDTEWQYIDLACRNRLVAVCNFYAFIRHIYLGLRATKSIDSLFEECFQLRLSMFYARSGVNIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEX1</accession>
    <name>A0A367JEX1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001463">
        <property type="protein sequence ID" value="RCH88460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEX1"/>
    <dbReference type="STRING" id="86630.A0A367JEX1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="43"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="439" mass="47924" checksum="ACCD7FA610096755" modified="2018-11-07" version="1">MPSENYATSDTSSDKFSKVEQTAIDRLEEDRASSINEFGHGSGNFMTAYFNVVCVVAGTGTLGLPSAFAKGGWLGILILILAYVMSVYSGIVLIRCLYHQPGKRLHDYKAIGTAAFGVVGYIIASVLHLLNLFGCPALYLVLASGNMVEMLKDTSAYYIQYKTWVIIWGVFLLIPSLIMKTLKEVTAIAAIGAVCTMMAVFVVVIQGPMYRNEHPDELIAHDSVIWTGFPIALSTIAFSFGGNNTYPHVEHALKKPHQWKWAVTAGLSTCVALYFMTAIAGYWSFGTATQSPIYNSLPDGPGKLLSMIVMTIHVILAIPIYSTSFSLEFEKFVNCSEDRLGKFGAWVGRAIIRACTMVILVILACFIPFFGDFMGLIGALANCGLVFLLPVLCYLKLTGVRNKPWYELAFCALTLLLGIVGCIFGTIDAIKALVHDFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH51</accession>
    <name>A0A367JH51_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L33A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL33A_2</name>
        <name evidence="4" type="ORF">CU097_010294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001318">
        <property type="protein sequence ID" value="RCH89282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH51"/>
    <dbReference type="STRING" id="86630.A0A367JH51"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="13070" checksum="B9E125CB130DAE60" modified="2018-11-07" version="1">MDGWTWDNVKVSILYCKGRVLGYERAKRNQNPNVSLIQVEGVQTTKDAQFYLGKRIAYVYRAQREVNGSKIRVIWGRIARTHGTNGVVKARFRKNLPPKVFGASVRVMLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ65</accession>
    <name>A0A367JJ65_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Karyogamy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">KAR5_2</name>
        <name evidence="12" type="ORF">CU097_006756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001234">
        <property type="protein sequence ID" value="RCH89741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ65"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH89741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="465" mass="54543" checksum="2044ABEF76F4324E" modified="2018-11-07" version="1">MFNHELFKALQNNENDCYKKATLELTKGCQSLEGDNPVDNMKYAVMLTLCELLSAKINVPSECNILNTHQQVVQCTQQLSLSPQTWTTYSGYFRDIVLICFAIKYPMEKEILERLHENITLNQVKNFNILSSQQRYLIQWREEEFKRLDKLKESQLDIFEHVEKTNMYYQRMAHQVELLFETLVLLQNQTELSILQYNDMVNRHVEQVQMFLQDSFLYQAMKIDETLDSLLTKSNTLNQHVERILLLQEQTDQSWSLLTKNLERELTDVWNQSVYRMSTGFHLIMNQSLSEAKLLQHDLTLIRRQVKDTMEPFHRLSNLISGVYFQGVHTVKRLIVLVVSCALLCLRIQALLKQMNVHRNQLFTLVLLIVASITCQQAHLNTIFSAVLLATTSIALEGIILYHRHKKVSAEALDRSEVKPLNYTQSKTDTEIRLQKVPNLDELSPPPPYQAKDTYYYHRYYYHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ94</accession>
    <name>A0A367JJ94_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_007521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001199">
        <property type="protein sequence ID" value="RCH89955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ94"/>
    <dbReference type="STRING" id="86630.A0A367JJ94"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834878" description="SH3 domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="234"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="33948" checksum="799FC52A4BB6D67A" modified="2018-11-07" version="1">MRWTTLFSLLFITAEAKPHLWKVNKRAEPTKKETEEKTIHFANNTQTKKSTTSKKKTTTKKPTSTTATLSSASLIPSSSVTASSIASSSIASSSTALPAHTPMVVSAPSPTSTQPTTLATPAAAAETKSNSGLSGGAIGGIVVAVVAVIAGVAALLVFRNRRKKTIMTRNNNSSDPFTVGYSNDNPPAMQQMTSPTHQSFNDPSPTLVSSQQYQAQLQPLAPPPPPLAQKEPQQSLGVYTVAATYSPTLSDEIDIQIGDQVEVLVEYDDGWCQGINLSRNNAKGVFPKHCLDFSSTQKEQTQQDDARVKRVSSMRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJG4</accession>
    <name>A0A367JJG4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Late Golgi vesicles protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TVP15_2</name>
        <name evidence="7" type="ORF">CU097_008175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001189">
        <property type="protein sequence ID" value="RCH90025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJG4"/>
    <dbReference type="STRING" id="86630.A0A367JJG4"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="18908" checksum="855FE27F146AFBAE" modified="2018-11-07" version="1">MNFANIFRVVNMVAAAFMIIGGVMTCIHGGFPNFIQGIFVILFGLMTVLFEFRMPGPVVKHASFMFSFMGRGLFYVFLGFITVNYGALSIASGVIVIVIGLAYVALEFTKIEPPNNMRKEAYDDAVGQSTHGNASLPSFVYPATYEQTTPYEQSSPYAQPESQPATVNVTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLQ5</accession>
    <name>A0A367JLQ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001056">
        <property type="protein sequence ID" value="RCH90863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLQ5"/>
    <dbReference type="STRING" id="86630.A0A367JLQ5"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="440"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="616" mass="73034" checksum="16FB6B927A5DA12B" modified="2018-11-07" version="1">MNETLPNITELRNNIDFASISQFFHTFQSAFHPWPTSTQQLIYRTRIEYGQEYVFETEDLERMFLDYSERSRLEDLIVRMLRLLTRNRFINSSTWQTYFAKEFDKRKPDMTNPFYNQQESIQTTDNPSMLDFFQLSLETRVHLLYLLCEWQLDDPERFREHLDSEEGSAQWRVDPIGYDSKGATLWLFDDNRLYMETPKPSVKLRKKKSRPAYKGTSRKSSRRAVAKKEPDQDMDENEQEWIPWKLICYSKQDWEQIASRYEHSDHADEKRFYNLLVNDLVPKVLPILEEREREIKKQEAIIHRKRSSRIMIRELEALERASSSEPEFDFSSPGVKTRSSNRIEQNPLDKERKEKENLAKAREERALERERRLMEREYRALIREKGQNENDREESPMAEERIANDNVKKKRKEKFDEYGNPIPKKKRGRKPKNKSAEDWFFSCICGVSGRNLDDGTPMIACEKCDTWQHIQCLQQSGQVDKNANQLEEVSFICQSCSTKEEDMDIDIEEHDDKQKVDTSFVNTTALNYSTQNPQPVNILPSHFRELRPNLVTEQVFPIQSMLLHQHTLQPAPPIVRDIQHQSTYPQQTTLMSQDSSTTDNKPVMNQLNNQDRIDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM35</accession>
    <name>A0A367JM35_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001037">
        <property type="protein sequence ID" value="RCH90987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JM35"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2018" mass="227101" checksum="81F7978C3DE8F0BD" modified="2018-11-07" version="1" fragment="single">QAVQGAAENYTRIEDLVIKPGTERTIQVSYRPQKDASINDFNAGQLIRRNFRIMLEYGTFRSAEPKQRKAIQCRARTCTSFVEVIPKVINFGDTDVGTLKSLPIKIFNRSDIMARVELQFISKVLNCQRGEITIQPRSYVELKLDLYPRKVNPDYRKQITLVNYLNKDNDQIIEVQSTNIDKNRVTFHSLFYRILTATGANFLDFGSIALNSPAIRTFTIENIRDKPLTLEITTSLPEDIVIYTRNKQKPTEDALASAAPSPPTSKLLNSITAESIEKEESSRDQSEIQAEMNEVTPRRRSKPSPESFSSRRITSNTKAKLSDDTNALEQKATSDNNKHSLASKKIQACIQQLKIDQVHLSTAYLDLALPPIKAKKRRIIQIDPNTPLLKNTRHGRLISIANGKEMASETIELLKRNRLAQHRQNSNGSSPSSSASSTPSTKKMTVAKGKRDVASVKILDNIGRHDSFGTRSAKTKRSLGITAARYKSRKNLDWSDIAGKSRVPFEDLISVLEHGSKAAPPLFPKQAAEEQFVRYQLAWRRELNRLIEKKILIPTSIVRVDPKQEEEVVVVMTPTSATKPHIQSAPKKQDARVFLRLLEFDRNIEQTEFENLLDLDNADIPVREVILRSQLCRSVMDLGQKNINFGLVERNERHTKTIVLHNRSETPLLYAIRKSGSIASGDIELDAGRYGVVRAYGKREVEFIFEPTLPGPFMEKLIVENIRDRTNDQVLLLKAQVRKPSTFLIKSLEITFGDCLIDQTCPRSESIVLTNTNKQSRMFEVRVDPNEVDFGHFYGEFDFDVKDDETNTISKEAEEEIENLEQKLKIAKRKAQPDKVKKYLRKLAKLKNLDQADSKSAPATGEKDTESPDTPLGSSSSSSSLALANAVKEGGAVFKKTAESVVFPLDAHATKTIRVSFKPVPRPLHTSDIPTRSQPISIKGRILVHEYKNTDVCKSVVYTANVFADEALFVDALTKDNGDGSSKAESTPVSGVVSTVTTPVRSLSESPFVEGNVSEMKEERQRENEDYLKLERDFFDSGRIEIDQKAVFYVRMTNESDKPVDFEIIGDPKDDVFQFEVVQDGEGMILKPHETRKVSYSLKPSKIGKHQYTFSIRNKRTCAIQSFTTQCLVHYSSYLDFPSLNDESNGVLDLGFSYVDPGSKYSQVTPLLVENTSGRDIYITCQSNLAHQVLIFMDEAGERGLVDMMPLKRGGMTTVWVAVQPNLLTGYLGNNSADECRELIGGIKFFIHEKDERNQDEMLLMLTQTVKFTSIIGQSHMEVSDRVINLGYTDLLDKDFYGAFTITNKSGQLPLDYEVECATGNIELDRRGGTLNGWLSTKQRGGIDMGISTNGKTEHGNNLELDISGYGSRRCSYDDMAAATSSLTQITFRVNAYQYGLLTEKLIVTNKRNSQEVFEIDVRLFVDCKKLDAWALPSKKLLHSTLLTNHQHGTADDQTEHLEADPLPMIKWESIYVRPLLHDEEHQKPALQLLDLPEQDIMKHYVRELDIANTSGQPMHLVVLSDLDIAAGWIVDEDKVKSTAVKHKNPVFNQRSGQFALQPGQRVRVRINCPSADKLNDDGRSLALQGKSGPLKGMMMLYDVRQSLEVLALELEALFCVSRAEISVDHINLGKIGHSTSYKPVRFEFQIHNLSDVPATYDIHSPLFVKFTPLDRNGVALKQKTFYIPSRKTQRVEGLLIPKEMPDQSSGLHHIDINIENLRNNSNIMNLQLKALMTVFELRFERLSSSGDLVLPTLHHPIMLPNTTCDNWFIIHNKTEDDLRFEIGADIESELKDYVSLDVLSRYTNSPLKGDIAIGPLGSIEVRVRASPNESSRLPRNRPEFTDPAGIVLAKLWVTTRPAEEDLDGYDIDDGRVKETILVRCVLEERGTFTLQEERLDFKLVTYYQENEEGSNLTDSACMPDSLPLTIINHATKVPLRFQVTVEGPAEFPAHELVQINGIDEEGKGIVNPDDRLTLSVAISNHKESVPGQLKIHVDDLDALGVSRQTVSMYVTEIVWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPR1</accession>
    <name>A0A367JPR1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000900">
        <property type="protein sequence ID" value="RCH91940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPR1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="82" mass="9403" checksum="692C1FFABAEEFA4E" modified="2018-11-07" version="1">MSRVLFAKLSKFRRRTKGTFIKVTIQHRKLFLVLQEVLAKVSASTFEDTQLPSVTVSSRGMQEHNCGESRNQRLTRGSFVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQX5</accession>
    <name>A0A367JQX5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_011502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000847">
        <property type="protein sequence ID" value="RCH92306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQX5"/>
    <dbReference type="STRING" id="86630.A0A367JQX5"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000041">
        <property type="entry name" value="Glutamine amidotransferase subunit pdxT, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="213" mass="23584" checksum="D624B9D8524EBC72" modified="2018-11-07" version="1">MSNDIIQVVIGVLALQGAFIEHMHMLKKIPQVKDVIAVRTEEQLKQIDALIIPGGESTSMALIAERCNMLEPLRAFVQQKPTWGTCAGMIILAKEAHGAKKGGQQLLNALDVSVNRNQFGSQKESFKTLLHLPDILGQEPFDAVFIRAPVISEIKSPNVKVVGRLEQKVGQTEAETAVAVLQDHLFATAFHPELTNDNRLHEFFVNLAIKYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRF6</accession>
    <name>A0A367JRF6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000815">
        <property type="protein sequence ID" value="RCH92527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRF6"/>
    <dbReference type="STRING" id="86630.A0A367JRF6"/>
    <dbReference type="OrthoDB" id="5587891at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="178" mass="20550" checksum="BB1ACFEE15BF753C" modified="2018-11-07" version="1" fragment="single">MDINFEHSSNVTLEAMNPFNITYDDLNEPTRSYLRLSTFTIAYLGMCLSCTIWQVITVAEMAWRKRKWLHYLLLFETLACFVTILCSVLNPFTPVDCITRFWIAIIVVNLEGCAIQTILLYKAYICYDRSILLLILGSLINLGYIALIFIYAAYGKVPTYKDIIGNCVLNNRTYQRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRG7</accession>
    <name>A0A367JRG7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000849">
        <property type="protein sequence ID" value="RCH92291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRG7"/>
    <dbReference type="OrthoDB" id="2229149at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="255" mass="28867" checksum="881114F23B039A78" modified="2018-11-07" version="1">MLITQNDSNSYGIKAVDWERFVQFSKGTFASPAVQLSSVEREIPGSSFSTKASNKQLRIKGSVFVDEEDVLITSFVEPLIMPFLRSIENTVIHGNGYPLHESYVRKAKVVGKYGLYIRSIRGRVPDRAFSFQMPSGERFMVLVAEVKTTANAARSLDFIKLSMLMKDVIDFASTKWVTNYFSIGLLIADASCKIYKLHMSIDRMYCMTEISAFHLPNNVNDILLKDKLQNIIVSMLQYLVYINKELGCSESVQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRS4</accession>
    <name>A0A367JRS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000804">
        <property type="protein sequence ID" value="RCH92606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRS4"/>
    <dbReference type="STRING" id="86630.A0A367JRS4"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="ENTH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="43095" checksum="0B6F3C59E0B7B9BB" modified="2018-11-07" version="1">METAVRKATRLEYRPPKQKHLITLRNITLESPSSIEKMLKLLEKRLGEGYWIITFKVFIILHYLIREGNTQKVTEAICMRRPQIFDISKIKNKKLVPGTIQNIYLYKTYLDRRVIAVGESQIDYTKSGTFRRLILSEGLFEETTKLQQLLACALSCKFCLNEGDPAISLFAYRLIIEDIFNLFQAVNESIINILEHYFEMTKSDALTSIELYKTFSAETQSVTEFFNAARPYEGALEMKLPPLNHAPTTLIDALKDYVEELDKPSPETTDQGTTGVNTKPFSPRPDLPTDNNPFATLALPPTNNELTRLSMPIASPTYFPQPFSPGSSLQRRITNPFSPVYMQPTGQSQQLPYDTNPFRTMYFQDPRQYPFSPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRU9</accession>
    <name>A0A367JRU9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNase P/RNase MRP complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">POP4</name>
        <name evidence="8" type="ORF">CU097_002766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000800">
        <property type="protein sequence ID" value="RCH92638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRU9"/>
    <dbReference type="STRING" id="86630.A0A367JRU9"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25504" checksum="3F577FA6C7605917" modified="2018-11-07" version="1">MNKSKGENVYQPLSGTTTASGKTALTAVKGLMEEFISPQTNVDKLVDELRPVYIDRSHTFVKEEEKKEEKKKLKRKKDRKLTAKEKRVLKVYEIPKEAHQYKLFEPLSELWQGYMDTLLDKGEANFEQKLIKADFHGAPFTVIQSTNPSYVGVSGIVVQETLSTFKIITRQNRLKQIPKNTSIFNIYIKKLDKSFTIYGQQFVARPSDRAAKKFKPKPSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSV9</accession>
    <name>A0A367JSV9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FAB1_3</name>
        <name evidence="6" type="ORF">CU097_009468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000754">
        <property type="protein sequence ID" value="RCH92996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSV9"/>
    <dbReference type="STRING" id="86630.A0A367JSV9"/>
    <dbReference type="OrthoDB" id="2276835at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052810">
        <property type="term" value="F:1-phosphatidylinositol-5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903426">
        <property type="term" value="P:regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043548">
        <property type="entry name" value="PIKfyve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715:SF1">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="5">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="256" mass="28431" checksum="48B55C1DCB7DD749" modified="2018-11-07" version="1">MDKENNNSLTSFQFEPKDNRTSEEGVLSKILDKVKSAVSGQPTSWTHDNASMHSTHSERRISNSTEPSVISIPHTVSNVIAVTEYPNSSSNSSTTSQRLPKDSVLANFPVSSDSLSKSSTIATTATTVIVGKHGKSEDMIVEPAHSNSTVQFIMPSTSNSNNRKSLEENSVDLLPLYTRKSIDSDTQSVATNFSISNSNSLGRILARLRGQKNDKEFWMPDEQCKECYKCRKPFTLLRRKHHCRTCGREIEGMPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTH6</accession>
    <name>A0A367JTH6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MNR2_5</name>
        <name evidence="8" type="ORF">CU097_011160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000726">
        <property type="protein sequence ID" value="RCH93216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTH6"/>
    <dbReference type="STRING" id="86630.A0A367JTH6"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="489" mass="56471" checksum="4E178515E95D5277" modified="2018-11-07" version="1">MDPSFPYYPPHTENACDQSIKGNAGSSLLLTTDPKDLDKLFDRSIEAEQDICFPTKRPISSSISSTTTAAFSPPPRKHNGHSSFQNNSINVNALSSWFTDIDMHSSMTQHYQPTKQTKKKLSLYGDNHHIVEDSKEDRYMYFHPDTGIIRGKSLLELKLPPHLTVEQLLLKENFWIDITSPSLAEMKAISKIFHIHPLTTEDIMAHEIREKCDVFRRYIFICYRAFLHDNYQLKPMTFYNIISKRHILTFHFGHVPHTEHVLERVIQLQDYIEVVPDWINYAIMDEITDSFAPMIQQIESEVDTIDDLVLLYKTDQTDMVLRIGTCRKRVIQMVRLLGTKAEVVKALMKRIEERTVRSDSLEEEANDAEMGRIYPDVGLYLGDVQDHILTMLQNLNHYETVLARSESNYLARMSIELTQTSNSTNHVIGRLTIFATILLPMNLITGLWGMNVKVPGKDYDNLIYFFWIVFSLVAFAILSLTFARKMKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTP8</accession>
    <name>A0A367JTP8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MSH6_2</name>
        <name evidence="10" type="ORF">CU097_011908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000716">
        <property type="protein sequence ID" value="RCH93286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTP8"/>
    <dbReference type="STRING" id="86630.A0A367JTP8"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03286">
        <property type="entry name" value="ABC_MSH6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126102" checksum="5EDE27223F39B644" modified="2018-11-07" version="1">MPDPKKPMGQSSLLSFFTKKTDSAPQSKPVPQSKPAPSPQNDSMQVDSTIAEDSNNTQKRRRAQVTYNELDSEEEEPVKPSATGKKRKLVRRISSEDSEDEYTPTDNNKEDDDVFDDISDTELMEIERDIATSKNRIPVTPIAEKFQKFSVSSTPAPPTFNPEATAKQTKAQKFKEKNETRYHWLQNLRDADGNPVDSPNYDPRTLYIPASAWREFTPFEKQYWEVKCKHWDTVVFFKKGKFYELYEKDADIGHKDFDLKMTDRVNMRMVGVPEMSFDYWAAQFIAKGYKVAKVDQMETAIGKSMREKNTTTKQDKVIRRELTSVLTAGTLVDAGLLTSDLSTYCMSIKEQCMNEQSEPRFGICFVDTATAEFNLVHFEDDMNRTKLETLLMQIKPRELITEKGRLTKSTMQLIKSTVNDPLWNMLIPEREFWDDRTTEDEIRINEYFGSEMTEKDNLSGFDHAMQELHTDPLLMSAFGAMIWYLRSLKLDKDLLSAKHIQMYDPIRLGTSLVLDGQTLANLEIFQNSHDGSTDGTVFKLLANSITPFGKRLFKRWLCHPLRRIQDINARLDAIEDLMQLNDAEIIAKQLASLPDLERLISRIHSGSVKVKEFLTVLEGFRTTEVIIETMKQNQSQLKSSLLNRLMDDFPQIGPALEELSGLFTTADVDMDYQKVKAMIPKSGKNADWDKLNDDIDTIGTEFQTHLTSLKKQLKCSSLAYKDLGKDIYQIEVPKGVSVPSDWIKLSNTAKFNRYWDSTVKRLVTKYKELLETKNEFVKKFSQQVYAHFDEFYPMWLSAVSAVAQLDALMGLAKGSMNMGEPVCRPTLLDQEKSIIEFEELRHPCVVPGVSTDFIPNDVALGGERSNMIVLTGPNMGGKSTLLRQTCVAIILAQLGSYVPARSCRLTPCDRIYTRIGANDNIMGGQSTFMVELAETSKILREATPRSMVILDELGRGTSTYDGYAIAYSVLHYLSTHIGCLGMFATHYQTLCREFERNPEINNMHMGYMMDEDEHNVTFLYKLTEGICEKSFGMNVARMANIPPSVVSRADEIAQQVEVSHRMKDTTFTKSLTPAVMSDLKYLINNHHRDARDAATRRIVNSFMHIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUH5</accession>
    <name>A0A367JUH5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RH35_2</name>
        <name evidence="20" type="ORF">CU097_007573</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000674">
        <property type="protein sequence ID" value="RCH93624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUH5"/>
    <dbReference type="STRING" id="86630.A0A367JUH5"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="188"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="383"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH93624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="594" mass="67452" checksum="E72C0C3E7EB685D2" modified="2018-11-07" version="1">MNSNLEDLDDDYVPYVPLKQRRLEKLHRYATQRHRSSHYRQHDEEVEDEPVNDVAGPRANMSLLDQTVQQRLSNAIPEKTEEEKRLEEERRIEEAQARHKALVSVQEAAAGKVYTEPMKSSWQPPKYIREMSVEEQQRIRNKYHIIVEGEDQVPPITDFRDMKFPEPILKYLKEKKIDKPTPIQLQGLPVALKGRDMIGIAFTGSGKTLSFSLPLVMFALEAEVRLPLTQGEGPVGMILCPSRELARQTFEGLSSMAAALVKGGYPELRPLLCIGGIDMREQYDVLKRGIHMVVATPGRLIDLLNKKKINLDNCKYLCMDEADRMIDMGFEEDVRTIMSYFKSQRQTILYSATMPKKIQEFALSALVKPIIVNVGRAGAANLDVIQEVEYVKQEAKMVYLLECLQKTPPPVLIFAENKNDVDDIHEYLLLKGVEAVAIHGGKTQEEREYAIQSFKNYKKDVLVATDVASKGLDFAEIKHVINFDMPKEIEDYVHRIGRTGRSGKTGIATTFINQHCSEQIRLDLKHLLKEAKQRIPPFLAIMEDPTEKYGGLSGGCSFCGGLGHRINDCPKLEQQRRQQMNSIMSSRHIGGGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUL5</accession>
    <name>A0A367JUL5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000675">
        <property type="protein sequence ID" value="RCH93617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUL5"/>
    <dbReference type="STRING" id="86630.A0A367JUL5"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="46283" checksum="74B7A3BBCEE16F5E" modified="2018-11-07" version="1">MLRLLANRNYTFRLQKRFYSELPYNRIHVPVMLSEVMQHLQPKDNEIYCDLTFGDGGYTKALLDHCNCKVIAVDQDPTAYEKALKLSQLDKYKTRLIPVLGRFGSIYDYCKSHFDRIPCFDGIVMDIGVSSGQLESPERGFSYKLDGPLDMRMFSRGRNSTDIPVHEDEAALLKKSISAYEIVNYFSREEIADIIYQYGGDRLSRKIASAIITARQKGPIETTSALAAIIHKACPQPKWQRGNDDMLRNSAARTFQAFRIYINNELGELESALKASEYLLKPEGRLAIVTFHSLEDRMAKRFLYHCSGKRSLADSQHNQFDLKRAVHRERKKAMKYTNDDDVDDTLFRQPSVKAESVSPSFEICTKHVIQPSEEELENNARCRSAKLRVAKRTNASPLAPFGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUN5</accession>
    <name>A0A367JUN5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000672">
        <property type="protein sequence ID" value="RCH93643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUN5"/>
    <dbReference type="OrthoDB" id="2271080at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="429" mass="48974" checksum="588B100CE93611E6" modified="2018-11-07" version="1">MVSTSDDDSIWEFDAPKFWNFTGETEQELPSDSWFSEKTVSGPSYPPHFYPPTPEAYTNRQTPAIARERLLDQSSSYNKKNESMTQKTSYDPLLSAPNNKKRPFGNDKNQQNIKSGASKKQRITSNVFSRLAQSNTIASISKMAKPPDMKHQAKLNHRNTTAVTKKPTTNKMNHTAITSATTTSRKLYSKQSEFVHRHVENSTVIDDPLSTEINPTVAKAQDSSTTHQKQSPRQEPISSTSHVSSNQDKKDDTPLPPYIPFTPPRQIIPDWFFFNSPEKATIAAIKDSPRKESPSFIKDQTSSPLQSKEKETRVPMFIQKNPFLEESPSVKKATNLPAPSRYTKLSTTGRYLNINNEPEGLLQSTENIKSPPKVVEKEDIRHIRHRRIIEDLRRRIYKKDPRHIRHKEIIEDLRLKVAKAVREAAEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUR6</accession>
    <name>A0A367JUR6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000663">
        <property type="protein sequence ID" value="RCH93724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUR6"/>
    <dbReference type="STRING" id="86630.A0A367JUR6"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016951839" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="22"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="344" mass="38515" checksum="7EA633E7BF3075BC" modified="2018-11-07" version="1" fragment="single">MKLSFIAAALASAIALCEGSTKMVIGYFPNWLYANYPVENIPYTKYTHINYAFAILNNPDNLPSFSDDWAVESGLPKIVQLAHKNKTKVLLSIGGWTGSKRFSPMVATAESRKRFIDWNIQFIEKYNTDGVDIDWEYPGRQAAGCNEFADNDADNFLLLLKELRFALDARFPNDRKEVSMAVHVQPFIKSGVPMSDLKAYVPYFDHVNLMTYDINGAWAPVTGPNAPFRYEPGKGSPFSFVDSIKQWKAAGVPSEKITAGLPFYGRAIKANVNMHATQPLNQYQPAQVGAPKGDSDDAYWDDPYCNVEPGGLSGIWKWTNLRKEGLIKDDFVSTGAGWTRHWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW97</accession>
    <name>A0A367JW97_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000596">
        <property type="protein sequence ID" value="RCH94272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW97"/>
    <dbReference type="OrthoDB" id="2252922at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="19061" checksum="BC24ECACEF9AD1D2" modified="2018-11-07" version="1">MSAENAQITSYMITDINAFVEDWHVRVTWIAFMTLWVFWGLVWIFRNFFVTNPTVSASPDTNATTDAEASNKKFFGAVNGSFAGRLDRAHQIVKDALFSLLCLLAMNSFARASTRAVMILAWFFTAFAVFWFVVELVVDNRYVRLLYSVIFYGLGLAIAGLAFKQGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWG5</accession>
    <name>A0A367JWG5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000599">
        <property type="protein sequence ID" value="RCH94245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWG5"/>
    <dbReference type="OrthoDB" id="2212706at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016883326" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="105" mass="11904" checksum="FDC17C5AFFBF69EC" modified="2018-11-07" version="1">MKYIILFFFFCILSVMARPSKPQLQTRLSKVGVNFSEIGCKCIMTDSTQDDRDTTLCLCFNRSNGTLNDSKSCSTLQDGVFQYCNDVTQNTPAWQLCVKQFCPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWI5</accession>
    <name>A0A367JWI5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000597">
        <property type="protein sequence ID" value="RCH94265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWI5"/>
    <dbReference type="OrthoDB" id="2268411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="195" mass="22618" checksum="648D7E9AB3B64F59" modified="2018-11-07" version="1">MCFPLKKFARDLSLVIVEIQNKVNHAFVARAIRYCLNIFDDVKKLPVLVISIDGFSSKEFRDFTFDKSDGNPFYTHLYQLWAKQVQVYIADSIAKHVDSSPIDPMIVLAYVLILQEKNIIMLDEYNDPNIQDIYRTALNIFSFGKDITNDLARRTESFCNAMASQFATILKYEKDCSEKSRKKTSSVCGRWNQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX73</accession>
    <name>A0A367JX73_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein transport protein yos1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">YOS1</name>
        <name evidence="9" type="ORF">CU097_011417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000561">
        <property type="protein sequence ID" value="RCH94592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX73"/>
    <dbReference type="STRING" id="86630.A0A367JX73"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9394" checksum="CB533F3CDAFAC3BA" modified="2018-11-07" version="1">MLTLGLGQLFYVLLCFINAIAVLSEDRFLARIGWTVQPEAGFGNEQSQTIKYKIVNLISAVRTLMRIPLIGINIIVIIYELLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX83</accession>
    <name>A0A367JX83_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000567">
        <property type="protein sequence ID" value="RCH94540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX83"/>
    <dbReference type="OrthoDB" id="10452567at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="120" mass="13822" checksum="81754C0408F61E24" modified="2018-11-07" version="1">MCFNSVWTESKGAKFRSFFDLIAIKDVSNSHGLEFTHNEISPVASSASSSARRSVTPFTGNLNSETKAHQDNIHFLQTELKSALKERKDYLLQNNINEEKKKWIHKRAKPLQQQEIEHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXA1</accession>
    <name>A0A367JXA1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000569">
        <property type="protein sequence ID" value="RCH94525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXA1"/>
    <dbReference type="STRING" id="86630.A0A367JXA1"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="11980" checksum="48C4489ECB027F91" modified="2018-11-07" version="1">MTLGENLADNGGLHAAYAAMKKTLTEDSPIVLPGLEKYTPEQLFFINFGRIWCNNMRPELSVQRVRTDVHSPNSVRVNGAVQNSAEFAQAFQCPQKPMNPSNKCQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXB2</accession>
    <name>A0A367JXB2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000555">
        <property type="protein sequence ID" value="RCH94642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXB2"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="17710" checksum="6E715379BEE39242" modified="2018-11-07" version="1">MQEERLPQYEPRGISGWLKKGGRKVSHKLRSLDESFHAHEHIVTSTAFAPTKTKQLLASAGGDIIFDNTPVYAFKEVDYGNTTQNRTDDSSASSSENHLPSSKSKRSSHLILDEAMPEERRRFNYPDSQIIVSADLHGSIKVWRMDSGIYDAETPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY94</accession>
    <name>A0A367JY94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GLO3_1</name>
        <name evidence="8" type="ORF">CU097_003770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000519">
        <property type="protein sequence ID" value="RCH94962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY94"/>
    <dbReference type="STRING" id="86630.A0A367JY94"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="428" mass="48315" checksum="6F6ED968D0BEAF12" modified="2018-11-07" version="1">MPEPTKEQIQLVFKKLKQNRYNKSCFDCHTKNPDWASVSFGIYICTNCSSAHRNLGVHISFVRSTVLDSWTWDQLRLMKVGGNQVASEFFSKSSISTTNDARQKYSSRAGQQYKELLTKRAAEDAIMHPTNVVIDIDVQEENEPPKKEEKKEEEKEVEEKKEPVSKPVEENPPVQTTQTTQTTPTTPTTPTTSTTSKPPTTRTTSTNRTAMGIRAPRKPGKTAKLGVKKAPVNFNFEVAEAQAKQDLERKAKYQEEEEKEETTKDEEGSRKPLSSRLMYQDNNTAKEEEYEKLGFGMARLNVSMPEQKPYTEETTSAREKFGSARAISSDQYFGRNEYDPAISAAEQSRLSQFSSAKAISSDMYFGRDSQEVDTYSGHDTVSLTDWDNVQDHAVAMARRIVDQAALDLDAVKDLAENATNKVRSYFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYL3</accession>
    <name>A0A367JYL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000514">
        <property type="protein sequence ID" value="RCH95008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYL3"/>
    <dbReference type="STRING" id="86630.A0A367JYL3"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="584" mass="66768" checksum="E88E2320AF5CEB8A" modified="2018-11-07" version="1">MLKYNQTTRTTGKNLVGIWRPAFIEHNQSLYAFGGGGHVTDDLRYLDLSTMCWKALDNVQGTPPSRRYGHTATKWKDSVIIVGGCTDNQEYCNDVYIFNLTTQTWHQPTTVGTINNRHLHSAVVFENKLIVFGGFSKTTDCNMCTYVLDEMCILDLNTMTWTTHYNMPPRYNHSATLVGNKMYIYAGKDEQGTTVSDLFVIHLQNEPYTAYPLICTDQFEDLGMVLAKSQHFCDTTCGKLFVFGRYANRRQLDNSDKNSSNNSISSDNDLIYGLWMLDLDTLQWKKQECSNHFEVGGWNYFIVIREPLNDKIASPRSQVSCNSLLFLGNTDSSKTQGYDHFRDALTINCESLGLYDLGEPRLPTTELLKLLNTPEYSDFSIRTGDGKEIYVHQVILLSRWPHFKNMCTSGMFESVTKTIVMPEPFDVVMAFLKYIYGDTLDDSEPWQILCELLLLANLYQLHRLKKLCCQRLYTHHMSIESCGYIFEKAIMTDEIGLKWLTLKFMFQNYGSFIKSNVFNQLSAIVQEEFVKAVPDEAVLEIGRSGYVAPKSMSCDRKETLVIEYPVETHTSLVYVGDSSLSLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ57</accession>
    <name>A0A367JZ57_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HIS2AV</name>
        <name evidence="14" type="ORF">CU097_014388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000493">
        <property type="protein sequence ID" value="RCH95187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ57"/>
    <dbReference type="STRING" id="86630.A0A367JZ57"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH95187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="14100" checksum="AB7311E13B844A25" modified="2018-11-07" version="1">MADSVSDNKKGDRRDRVPTLSQSARSGLQFPVGRIHRYLKAKGHNHSRVGAKAAVYTAAILEYLTAEVLELAGNATKDLKVKRITPRHLQLAIRGDEELDALIKATIAGGGVLPHIHKSLIGNTKTGKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZF3</accession>
    <name>A0A367JZF3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Minor histocompatibility antigen H13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_006180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000509">
        <property type="protein sequence ID" value="RCH95041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZF3"/>
    <dbReference type="STRING" id="86630.A0A367JZF3"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53142" checksum="D4DE045664B925DA" modified="2018-11-07" version="1">MPQYFNTTDDWLTLIGASLALLALAMVPICIGSSISLQMMKTPSKKKIMFAHTMDDDEVKTQVLSSRHALFFPIAGFIALFYTYLALKAIDPEYINEGIAIMTSILSTALMSNTILLVAKNNIPNQWLEKIDDYQFSFSRRGQAMCELHVTVIHLLIFAISIALSITYAITQHWAIGDLFAVSLIINAIGFLTVDSFCTGFILLCGILIHDLLWLSGSEAIVDITESFSGTPTNIVWPRYIETFVLNKLVQENQLFTTFSITDIIIPGIFVAYCLRFDRERAWNKGVTSDEFDKPFYNAAVVAYAAGAGTSIIAVHLTKKAQSALFYITPALLLSVLLTAIKERNLREVTDVTPFIQSIKKLNFMADRDERPERFVPRSSSTSGKNGKSHSSKTSRSRTRSVSKGKRTRGKTSKPVDVTPPTSTGISDIDGTVRSSPESTKQGTVNGHEHQITSDNSKRRYSSRISKKKQLEDYIETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0C4</accession>
    <name>A0A367K0C4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000447">
        <property type="protein sequence ID" value="RCH95636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0C4"/>
    <dbReference type="STRING" id="86630.A0A367K0C4"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="25704" checksum="74BB918436F4682A" modified="2018-11-07" version="1">MAHAPRNSVLVPGVSRYSRSAVYSKKALYKRKKTNVAAPAKQTAADKTVEVKGAKNGGKRVVPAQKAPRFYPAEDVPQPKVTRKTSKKTVLRSSITPGTVLILLAGRYRGKRVVFLKQLDSGLLLVTGPFKVNGVPLRRVNQAYVIATSTKLDLSSVKIDEKFNDAYFKKPAKAEKAFLEGEQKKAAFPESKAADQKALDKEILAVAAKDALLVSYLKSTFSLRKGQFPHDMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0L4</accession>
    <name>A0A367K0L4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_003676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000437">
        <property type="protein sequence ID" value="RCH95726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0L4"/>
    <dbReference type="STRING" id="86630.A0A367K0L4"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21348" checksum="9700CC7DFD906216" modified="2018-11-07" version="1">MRTALRKKIVIVGDGACGKTSLLIVYQNGKFPEKYLPTVFENYISRVELDNKSVELALWDTAGQEDYDRLRPLSYFETDVVIICFAVDNMNSFQNVRDKWLPEVKHYCGNNVSLVLVGLKIDLRSTESKTIISYQQGLKLAKEIGAKYGECSAKENIYVKEVIQLAAQMAIKPKRLFMKRNLQCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0Z2</accession>
    <name>A0A367K0Z2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COP9 signalosome (CSN) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CSN12_1</name>
        <name evidence="3" type="ORF">CU097_009631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000424">
        <property type="protein sequence ID" value="RCH95874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0Z2"/>
    <dbReference type="STRING" id="86630.A0A367K0Z2"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="214"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="47702" checksum="6212F9D938D03FF6" modified="2018-11-07" version="1">MYRQKTAYIESFLQKIKKNSQEERGKPLAALFAYSEKHVDQLVSHNLRPQELQELINRAQLESPWNDIALHHIRTAINLDQEDYEEAFLSQKELVQSFQRNMPNFTRWVLPVLYVFNNDLRLIATRADQDKEAEEGQRRKLEEAANVISKSFTGCITDRGVMSLSKKYGTYRMIGMLFRIYFKLKQQNLCKNILRAVKAADMPPIEQFPKSDRVTFRYYLGRLYFLEEDYTKAENELNLAFRECTNRHVKNKELILQTLLPIKLMKGVLPTQALFSQFPEARHVYSDLAAAMKKGYVKAFNEALSKSEPILIRQRTYFAVEKAENIAIRQLFRKVYLLMGQNTRLPIGKFKQALDFEGMNVDIEEAEWMLANMIYKGYMKGYLSHEKMFLVLSKDNPFPSVGQVSNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K144</accession>
    <name>A0A367K144_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000449">
        <property type="protein sequence ID" value="RCH95611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K144"/>
    <dbReference type="STRING" id="86630.A0A367K144"/>
    <dbReference type="OrthoDB" id="2287621at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="128"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="204" mass="23658" checksum="FBA312ED41466ADF" modified="2018-11-07" version="1">MRRTTAKLKKFPTRASAKFQAIHKKIKALRDVDAQYEVNFITTLGKYAKSASISLEKYKELGSENEEDDEEQEIDKQEHGGSEQAMHYLFNQLRVVAKNRILEEEPATEYVDDNNESSAQDSSESISKGTTTAHFIKFMNVLLDILNLNEYLKESYLVMDNCTIHKSKPMMRKIKSRGYKLMHLLPYSPELNLIEQFWAILKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3G6</accession>
    <name>A0A367K3G6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptidylpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DPP8_2</name>
        <name evidence="6" type="ORF">CU097_014043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000339">
        <property type="protein sequence ID" value="RCH96764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3G6"/>
    <dbReference type="STRING" id="86630.A0A367K3G6"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="5">
        <location>
            <begin position="140"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="4">
        <location>
            <begin position="651"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="856" mass="98682" checksum="A2A045EA108EBFB7" modified="2018-11-07" version="1">MNYSWDTIRDQVRDFRTNLQAIYPLQILSTVKEFTIDASNQLYFLSDHLALANEISPSRNLQLYHVDLNKIPYSDWLNKSDRMTEAEYLAACSKTPLLEWNVLFEEYCNPKTGTHFRLQGITSYDIKDDTVMFTSHNGIFISKMEQIPKLVYSRSMHICNTQSTERYPTSKTLLSDGRLDPKLGGNHVDKIAFIKDRDIWVMDLEGNERQLTFCSLNTKDPTLNCGGVEYMMQEEFHRFTGYYWAPSDPDSPVDRIVYLETSELEVELLRISKPVISFSGSDTLLNHTECMRYPYAGKPNATSKIRIVEFSDTEIIHRKLLDHDELHIAFPWMEYIVRFGWIPNGQSVWAQILSRDQKRTAIVKLALEQFTSSSPSLSTEILWEETNSAWINVTDAYYFMKQTDATITRLIWSSEKSNGYRHLYLVEKYIDQPAVITQLTHGEWCCLDKPIYVDESRGLVYFSAKADTPLEPHFYVVSYIRPQDGIRRLTQPGFSHTVTMTCPDYFVDCFSNLRHPHVFSVQKIDHSSLLPSPSNYKGLILPVCRITPYQNCSPYITNTLFLQTNSPAAENIKHYEEATSVYESVLSNGHLFSFTTSDGVVLYGCLYKPRSYQPGYSYPTILHIYGGPKSQMVVNEFRFPRLMRYLMSVYFGFAVVIIDGRGSSDRGLHFESHIQYRLGTVELKDQIEGLQFLYNTKFGAGVTMDGRKVSVVDLNKVAITGWSYGGYLSLMALGQYPDLFKIAIAGAPVTQWELYDAAYTERYMGLPSENRKAYAKSSVLQYVRDFPDSGNRLLIAHGLIDENVHFKNTEALVTELVKHNKHHYLQVYPNEKHGLRHASVNEHFETLMFYWLTNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3R2</accession>
    <name>A0A367K3R2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_012389</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000361">
        <property type="protein sequence ID" value="RCH96511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K3R2"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1154"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1543"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1578"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1604"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="14"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="911"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="17">
        <location>
            <begin position="1816"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="571"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1683"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="114"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH96511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1874" mass="211590" checksum="F5CE737B5E0618DF" modified="2018-11-07" version="1">MKKSRKSNLKEDDSNRIDVSTLSNTSSESITSCLRSRYNELKIYTNVGSRHIIALNPLKELPMNDDQASLEYVAAYKDATGHKQTPDPHLFDLINRTYFHMRRTGSDQAIMLKGVAGSGKSEIRRLTIRHLVRLSSHKKESKVQTQTIESQKVLEAFGHCQTNTSSSASRFSYYGEIQFNERGRMVGSKTLHYSLESSRVTNSSITTASDGNFNIFYYLLAGVSPDERSTLQLTDPSSYPYLQKFKRPVLPTDAQRFEDLKVAMKHLGFKKEQIGRVIQLVATILHLGNLSFVDPTGTGTQEAAFVKNAELLDLVADFLGLDPHALENVLTFKTTMIRKDITTLILNAQQAAEQRDELCQVLYSLLFSWIVEKINSKTCTEEFNSFIGILDFPGLQSYYPVAGFEQLCVNLVNERIQQYMDQALFQMETDVFRAEGIHVPDINYQSTALDLLTRPKGICHEVNTMTDVSKRAYTDNNIMDSIIKFNSTHPAFSVKNSDTNARHFVVQHFGNTPVEYSTEGFIAQNNNQISVDFLSLFKGGMDVQPSWNSFVVELFANVKTQSHPKHTTAIISAQQSAKPIRAPSQRKSTRRTNGNNGSNEKGGSDGTGPTTVLAQIQSALDELIESLGEAKLWIVYCILPKLKESGNFDTKLVQSQIDMFKIPSLLQLPTIQYVESYEHQEFLEHYGHLFEGLDTTRLLRSQCEMAAGIMGWTAPNMSITQNKVFLSAIAWRELEDKLRSYEKVEQRQAKDSNKEGDTGSVSHPFAAAAAAAGLPLPPQNYYDNDHGSFYSEDESGQYMEQEGSFYGSESYGSHQGGLALIPQQAPVVENINETEEDETKMSAGRKRWLFFVYFCTWWIPSKFLVWCGRMKRKDIRVAWREKVTLCMIIFLMCAFVIWFLVFFSEVICPKQHIYSPAELASHDKTNSKGAYVAIRGEVFDLTKFAPHHYPMNLVPTSSVMEYGGQDVTNLFPVQVSALCPGVSEFVSLDYQINLTDTNGQYHDFRYSSDVYNPNWYYDQMTMLRKNYKVGNMGYEYKAISDQASAATTINGIKALRIWAVINDRIYDLTSYTMGGRYARGPPGTTPPADINPNFLSQQVVDLFQQHSGQDITNSFYSLNLDQASLQRELVCLRNLFFVGYVDSRNSAKCQFSEYLLLVVTCLLAAVIVFKFVAAIRFGGKRAPEEHDKFVICQVTCYTEDEESLRKTIDSIARLHYDDKRKLLFVICDGMIVGSGNDRPTPRIVLDILGVDPQVDPEPLSFVSVGEGSKQHNMGKIYSGLYEVAGHVVPYIVVVKCGNPRERQKPGNRGKRDSQLVLMQFLNRVHYDAPMNPLQLEIYHQMKNVIGVSPEFYEFVLMVDADTEVMPDGLNYLVSSAVHDSKIIGICGETTLANEKDTWVTMIQVYEYFVSHHLIKSFESLFATVSCLPGCFTMYRIRTVDGKRALFISNEIIADYSVNVVDTLHKKNLLHLGEDRYLTTLLLKHFANFKTKFNSDAQCKTNAPDTWSVLVSQRRRWINSTIHNLGELVFLPRLCGFCCFSMRFVVLLDLISTAVMPALLGYLGYLIYTLATWEGSVPIISIATIAGTYGLQALLFIIKGRWEFIMWMIVSLFAMPVFSFYIPIYSYWHFDDFSWGNTRIVVGEKGKKMAVTADEGTFDPKSIPTMKWSEYEQQILSEDRWSDNVSQSSGYTHGSRGNYPRPGPGSVYGAASGMMMMPDNMSVHSSSRSVAQQQQQARQTMGFDHNSMIFPSSVSTPMMPYTNNSTSMLPSSRSMASFAPAQQFNTPGQYIPLQNSSQFNKAGSSRSLMMDGFNTEGPKNEEIMQQVQRILETADLTKVTKKQVREELQNIFGVSMQSRKDYINACIESVLQNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K433</accession>
    <name>A0A367K433_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HIS3_2</name>
        <name evidence="10" type="ORF">CU097_010810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="PJQL01000326">
        <property type="protein sequence ID" value="RCH96905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K433"/>
    <dbReference type="STRING" id="86630.A0A367K433"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="21426" checksum="CB59C21DB6611CE1" modified="2018-11-07" version="1">MEARTAIVERKTNETDIKVSINLDDKMNQEIKIDTGIGFLDHMYHALAKHGGWSLELHCKGDLYIDDHHTAEDTGIALGMAFKQALGTPKGIQRFGNAYCPLDEALSRAVVDISGRPFADINLDLKREKIGELSTEMIPHVLQSFAGAAGITLHVDVLKGQNDHHKAESAFKALAVAIRQAASRTGTDDVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K537</accession>
    <name>A0A367K537_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000292">
        <property type="protein sequence ID" value="RCH97269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K537"/>
    <dbReference type="STRING" id="86630.A0A367K537"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017033289" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="154"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="447" mass="47642" checksum="E01C15BB6F6A5F72" modified="2018-11-07" version="1">MIGFYNSLILSSAILIATAVNAQSNKTLSAPPAQTSPSYLSDVVPLTGNVKAYPGSNATIPTGALPSLTFNATGYPTTWKTPPVDSPEVKAAINSIDWGLVPNATVRKADSNGDLSMSGYDSNSDPDCWWSASGCVQSKNPIIPPDYYRCPNVGEWGLTYDDGPLTSDAGSWAEPNLYNFLAEHNQKAGLFYIGSNVIQAPAAAQRALADGHTICVHTWSHPAMTSLQNDAVVAELYWTLRAIKEVTGVTPKCWRPPYGDVDDRVRAIAWQMGMVTVIWDEDTDDWNMPGSGGGNLSPATVDGYFEGWIAARKNGSDSSTGHIVLQHELNNATVSMAEKWLPQIKEVFNVMPWNQCFNISQPYWETNFVYPTANGSIPANTTTANTTTIANVTTSIPSSSASSPSQAPIPSGISAANANSSTSSGTRLSYPSVITVVLGMAAIAYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K660</accession>
    <name>A0A367K660_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000259">
        <property type="protein sequence ID" value="RCH97658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K660"/>
    <dbReference type="STRING" id="86630.A0A367K660"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61518" checksum="01269C763CC7448A" modified="2018-11-07" version="1">MNYETLDIIQKNLIHLIEKWKPSRQSNTQWVATLGLSGIATYFLCKTVIYRLYIHPLNRIPGPRVGWIPFMGNFFNIMNTDVDQSPFIRWKEQYGGIYSVHFAWNEPRLIVSDEKLLKQILTTQQYDFEKPPFVSKALRRVVGNGVLLAEGDVHSTQRKMLNPAFSVHAIRSMVPLMATPGYKLRDQWLKKMTESKSEYTEIEVSLGLSLATLDVIGLTAFGQDFKSVENYGTERLHKISKAYLQIFNDDSSWLQILQFVFPFIKYLPTRRLFNTVRSLRWLHEEAEALVEAGIERAKKEKASGTSDGPKDLLALMVDLIDEGTGKGFTKEGLREQCLTFLAAGHETTSNTLSWCLWLLAQHQDVQDRLREEVRVLFQDENSFDYETINSISYLDYVCRETLRFIPTVPRTSRVNRVPVTLGEYTIPKGTVIHITPISTHRSKEIWGEDADKFNPLRWEKPDHIGNAYQYMPFLAGARQCIGNKFAMLEMKVLLSILLHHIQFFEKPGFKVRKIQMVTTKPVPNMTLFAKPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6N7</accession>
    <name>A0A367K6N7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_004464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000237">
        <property type="protein sequence ID" value="RCH97922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6N7"/>
    <dbReference type="STRING" id="86630.A0A367K6N7"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="52"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="256"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43455" checksum="4DE667C8FA2AF51D" modified="2018-11-07" version="1">MSQSQLDYSHDPSHESYDLIVRNDAPFNAEPTPPDLVKHYITPEKYFFCRNHGPIPLLDENEHTVEVRGIGCKEVKRLSLKEIKDYEKVSVMMVMEGNRRDGLHRVKHTKGVIWGPCALGNAVYSGCRLKDVLESLGVTSKLDNFSKLHVAFESVEQCEEDRCYGSSIPLAKALDEFGDVLLAYEMNYKPLTRDHGYPIRVVVPGYIGARSVKFLKSIVIQDQESSSFFQQRDYKILPESINTEEQANAYWTRLPAIGEYNVQSYVCIPADGVHSGPRPSEQVQGYALSGGGRFIQRVDVSGDDGKTWVTAQLYQPAAEGNSVHVWGWCLWTATIETKRNVRIVSRAVDSAGNIQQEYPIWNYRGVMNNSWRTVESNRLEQANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K784</accession>
    <name>A0A367K784_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KGD1_2</name>
        <name evidence="19" type="ORF">CU097_011074</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000230">
        <property type="protein sequence ID" value="RCH98016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K784"/>
    <dbReference type="STRING" id="86630.A0A367K784"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="648"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="972"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH98016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113881" checksum="1F289241B9546EDC" modified="2018-11-07" version="1">MYRLSTLSKVSRTLRPSVVPKLKQSAIRTSVASFHTTRSRYAAPESSDGFLHGSSANYIEEMYEAWLKDPSSVHLSWQVYFKNMANGVAPGQAYTPPPTLVPSASARLPVLPGDGITGAGSSEVIDHMKIQLLVRAYQVRGHHIANLDPLGIQHADLDASTPPELEYSFYGFKDSDLDRTFTIGPGILPAFTRNGSTSLTLREIINHLKKIYCGSIGVEYIHIPDRAQCDWIRERIENAQPYKYSVEEKRVIFDRLTWSDSFERFVASKYPSEKRFGLEGGETLIPGMKAMIDRAVDNGVESIVIGMPHRGRLNVLSNVVRKPNESIFCEFSGAIEPSEEGSGDVKYHLGMNYVRPTPSGKRVHLSLVANPSHLEAVDPVVLGKTRALQFYGNDPKGEKAMAVLIHGDAAFAGQGIVYETMGFHDLPSYSTGGTIHVVVNNQIGFTTDPRYGRSTPYCTDIAKSINAPVFHVNGDDAEAVTYVMQLAADWRQTFHRDVVIDLVCYRKHGHNETDQPMFTQPRMYEAIGKQVPVAKKYEEQLKKEGSLTEEDIQANKKRVWDILEESYARSKDYKPKSSEWLSSSWPGFKSPKELAEEILPHHPTGVPLETLQTVGKALTTLPHNFNVHRNLKRILQNREKALEEGKGIDWATAESLAWGSLLTEGKHVRVSGQDVERGTFSQRHAVLHDQKNGAKHTLLNNISPEQGVLSISNSSLSEYGVLGFELGYSLVNPDSLVVWEAQFGDFANTAQVIIDQFLAAGEQKWLQRTGLVLSLPHGYDGQGPEHSSARLERYLQLCDDYPYTYPSPEKLERQHQDCNMQVVYPSTPAQYFHVLRRQICRQFRKPLILPFSKSLLRHPLVKSDLSELTGDTHFQLYLPEEHPDTLVEPEKIRKHILCTGQVYYALLKAREQNKINDVAISRVEQLNPFPYEQVKQHADKYPNAEIVWCQEEPLNMGAWQHVQPRIATSLSQTQHHAGKTPVYVGRPPSASVATGNKKQHVQQEQELLSKALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K861</accession>
    <name>A0A367K861_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional polynucleotide phosphatase/kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000230">
        <property type="protein sequence ID" value="RCH98021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K861"/>
    <dbReference type="STRING" id="86630.A0A367K861"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="47168" checksum="D2E6937D8BCD41DC" modified="2018-11-07" version="1">MKREAKEDNNNIEENKKAKKEHPFFNMKRVDKGTIKWINVLDTVLVGKTLGKETGRTKIAAFDLDGTLITTKSGRTFPKDEHDWRWWCQTVPKRIEELYKEGYEIVVFSNQNGLNSDKKIKSFKIKIENILNQLSPPVFFMAALAKDKYRKPMTGMWHWFVQQHDQEIDKDACFYVGDAAGRDRKPKKDHSCVDRKFADNLQVAFHTPEEFFLNEPKADFEWLGFNAKEHPRDLPLLSPPLPSFPATEKNEVVICVGYPASGKSSFVKKHLVPKGYVYVNQDELKTRDKCIKACQEALSNEKSVVIDNTNPEKSTRQLYIQLAQKAGVPVRCLYFGQDENLAQHNNHYRAIHESSRDLISKIVFRTFKSKFQEPTMEEGFAEIQRVNFVFDGSDKDYEEWKKWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8X5</accession>
    <name>A0A367K8X5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000178">
        <property type="protein sequence ID" value="RCH98683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8X5"/>
    <dbReference type="STRING" id="86630.A0A367K8X5"/>
    <dbReference type="OrthoDB" id="2272101at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="186" mass="21128" checksum="72CBAE01FDA44808" modified="2018-11-07" version="1" fragment="single">MTIQVRSKRRILPKRSVIDIDFVSPKSNNLQDLLCTSTQIPSKKDYSVINELFGDQSQFPSQREHLPHIVLGTPKKSRLLQKQEDREKLVESQKIHENIPVKSSDQENQDEKHVVGQDVIEKTKGLSNGKKDVTSSSTTNTSIVNTNTSDIISKVETMCNDAVSETLYNKQEEMKKRYSISEEPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K931</accession>
    <name>A0A367K931_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000182">
        <property type="protein sequence ID" value="RCH98629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K931"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="230" mass="25936" checksum="04CE8EF36893CE27" modified="2018-11-07" version="1">MDEEIVQRIANLVNVLASQQQNNQQLALDISKQILEVKQKAGTVKCLSEDQPNTIPSSVPPEQRDEVIDSLKSQLTKALSEQEAIRQQNQELEKERDALQNLVKEYENGLETVTNKLRAYANAAAEGEMRLRREFNALLEAEKGTSATLFTENILLQMQLTQLAKTLRVAFEAKSLDGCYEEKIAQLEQEKKNFMDVLGISAEESESDGNRSPILHIPRTSGVIEEFFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9N5</accession>
    <name>A0A367K9N5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET and MYND domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000158">
        <property type="protein sequence ID" value="RCH98952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9N5"/>
    <dbReference type="STRING" id="86630.A0A367K9N5"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64809" checksum="9B110F513C7C603B" modified="2018-11-07" version="1">MNAFLEHHNLLLVDSKDPIRGRYVKSTTRITKGTVIITSQPLGTVVLPQTANEYCNYCFRKQTQPPLQRCSRCKATYFCDMGCFRNAWLSYHQFVCTPVDQQEKTMTAENDLDLEMLEKVALNVSRYRKRESKDETGGDEETVDVTMEAFFSLMGHDKLQRPAVQRAYRQIAQTALKKVYIRETGLTEDELVHYLNVFKSNNFAIDDKDMFAIGEGTYPIASLFNHSCRPNAVIMYDGALAEIHAIEDIEPETEITVSYLDAAHSRTYRKRMLKDKYFFDCRCLRCERHEEKPYVALIDELLGEEESEWDRADEILNGGKNEARSYVMKQIDEWDLLEMCKIYDRKSSGCPDPSEPLSIAHYTHYFIQFFAPYLLTWNQPHLHQQYVGTTRKTQLTDFDDPLPALAKPPVQATYDDILSTAIETMKQYPTSSSTLIPYRLTTLSVCSRLMYDQMAEGHWEAAVKLGMYVLIQYCLIYPPYHPMLARHFLTLAKACWNSIIQQELLNNGRQLAKVFERGVRRWIMSSKETVAVAFGKHSSLWRETLELEWIFLREQNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA64</accession>
    <name>A0A367KA64_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">METAP1_2</name>
        <name evidence="13" type="ORF">CU097_012600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000144">
        <property type="protein sequence ID" value="RCH99133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA64"/>
    <dbReference type="STRING" id="86630.A0A367KA64"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008970">
        <property type="entry name" value="PRK12318.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH99133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="39393" checksum="DA5D841138524EA3" modified="2018-11-07" version="1">MLEKRICAFTDCQNEAHLQCPTCIKLNKTEGSFFCSQDCFKKSWGTHKANHGNHKEPYDPFKTFKYAGPLRAVYPLSPRRQVPPEIQRPDYADTGIPKSEFMAKRSEIRVLNADEIEGIKKACQITREVLEVAAKAVRVGITTDEIDRIVHEATIERGAYPSPLNYNYFPKSCCTSLNEVICHGIPDQRPLANGDIINIDVSCYYNGFHGDANATYLVGDVDEVGQKLVKVTRECLDLAIAAVKPGIRYRDFGKIIEDHATKHGFSVVRTFCGHGINQLFHCAPDVPHYANNKAIGVVKPGHIFTIEPMICEGVHQELMWPDGWTATTKDGKRSAQFEHTLLVTETGVEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAE8</accession>
    <name>A0A367KAE8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_014735</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01000142">
        <property type="protein sequence ID" value="RCH99165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KAE8"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="339"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1349"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1356"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1400"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH99165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1669" mass="186522" checksum="D69359F5E2216345" modified="2018-11-07" version="1">MVCLLTQIKFPLSAPTTKRPIMNISVPIGTEVDYVSFSFYEPSEIRKISVKQIFNPILFDALGHPTKGGLYDPALGPFQKTQICATCSQDHFNCPGHFGHIEIPIPAYNPMFFDNLYAILRAKCIYCHQFRISRALMKKYSAQLTLLQHGLVNEAQSLNELVLDFKKTEAKDDETLEDRMEEQALSLSTVEDYIEHIDTFMKNALADEESRKYAAKDYKVTVINEVRKSVMRDFMKQCIHSKKCANCSGISPPIRRDGAAKLFQLALNKKDQAAMDRLNNQTGSFEEIKGFTNGQRFLTPYEVRKHVQALFEKEGDITTLLFGARDPRVPSFIKKATYHMFFIEVLAVAPTRFRPPSVMGDKTFESPQNELLSNILKGSHLVRDLSEELQAISDQEPVDKKKLEATRNRFVDSIIGLQHAVNSFIDSTKNPTQVAQGKNLPPGIRQALEKKEGLFRKHMMGKRVNYAARSVISPDPFIETSEIGIPPVFATKLTYPEPVTPHNIKEMRQAVINGPNKWPGATHVQNEDQSIDVLGDLSIESRIALANSLLAPQSSHTAQSGNNPYPTRTQTINKKVFRHLRNGDMLLLNRQPTLHKPSIMAHKARILPGEKTIRMHYANCNTYNADFDGDEMNIHFPQNEIARAEASFIANTDNQYLVPTSGNPLRGLIQDNVDSGVWMSSRDTFFTKEEYQQLLYGSLRPETDGTGGGKIRMLPPAIMKPQPLWTGKQVISTILKNLTWGKAQLNMTSKSKVPAKFWGPNAKEEDKVLVMDGELIHGIMDKSQFGASAFGLVHSVYEIYSPEAAGMLLSILSRLFIKFLQSHGFTCRMDDLVLTKEGDQWRRELLDQGVGLGDEAHLEFLGLADTAKTASPEVLSKEFKLRMNEVIRDDNKLAGLDNAMKAKVNKLTSSITQKCLPDGLIRPFPKNDMQMMTVSGAKGSNVNATQISCLLGQQELEGRRVPLMVSGRSLPSFRPFDTSARAGGFVTGRFLTGIRPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLRVHYDHTVRDSDGSVLQFHYGEDSLDVIKAKHINQFSFSAHNFEALSQKYHPKAALASLEIKQGEEYAKKALKKPGKYDPALSVYNPGTHLGVVSERFALAMKDYIQKNPDGMPFEKDSQLSKNTARYAGLTKNKFKALMNLKYLHSLVEPGEAVGLLAAQSVGEPSTQMTLNTFHFAGYGAANVTLGIPRLREIIMTAARKIKTPTMLLPLLPETSAKKASQFCKSASRLTLAQLVDNVVVREKTSAKTADNNYKRSKTYSIRVNLFEEKEYNEEYRVSAKRVKEVLATAFLKDLEELIRKDIKDTKKIEDISKAHKMDAPGDEDANEDLGDAAAKDGYASDDAEDMDAKTARKSAQNKPQASYDEPDEDDIVPEDNEKSLEDEEEEFEQAILAGADDEEEVPKRPSSKGGKLEEQAVQKSKYCTRFKFDDNNGAFCEIDMEFPADTKKILMISLIEKSCARVVVHEVKGISKCFEYINPTENDTSKRLQTEGVNLRGMWAFSDIIDVNYIDTNDIAAILNTYGVEAARNAIIKEVASVFAVYGIVVDRRHLTLIADYMTFEGGYKPFSRIGIGSNVAPFLKMSFESTCKFLTEATLHGDFDTLDSPSSRIVVGRVVEGGTGSFDVLQPLTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAI9</accession>
    <name>A0A367KAI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GSY1_2</name>
        <name evidence="9" type="ORF">CU097_013592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000141">
        <property type="protein sequence ID" value="RCH99177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAI9"/>
    <dbReference type="STRING" id="86630.A0A367KAI9"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="687" mass="79119" checksum="2F4128F7BC7C10A9" modified="2018-11-07" version="1">MGAVQRDVYNPLLFEIAWEVANKVGGIYTVIKTKVPVTIREFGDRYTLIGPLNYKSAPMEVEACEPSNPHVKACLDEMSEHGVKYLYGRWLIEGSPYVLLFDTNSVFHKLDEWKGDLWRSAAIPSPPADTETNDAILFGYLITWFLGLLTPKYNQSGDPAIICHFHEWLAGVALPLIKKRHLDVCTIFTTHATLLGRYLCAGDVDFYNNLANFDVDAEAGKRGIYHRYCIERGAAHCADVFTTVSHITAYESEHLLKRKPDGVLPNGLNVVKFSAMHEFQNLHALNKEKIHDFIRGHFYGHYDFDLDNTIYIFTAGRYEYRNKGVDMFVEALGRLNARLKSSGSKMTVVAFIIMPTTTHSFNVEALKGQAVTRQLRTTVSEIQDRIGKVIYEHALRLEDIDPAKFLSDADKVLLKRRVFALKRTSLPPIVTHNIVDDHKDPVLSQLRRLQLFNNWDDRVKVVFHPEFLNANNPLFGMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCFMEENIENCDDYGIYITDRRMRSVEESLQQLCDQMYQFVQKTRRQRINQRNRTERLSDLLDWKRMGLEYIKARQLSLRRAYPESFVDDDEDFQETAHVKIPKPLSAPASPRIRMQVNTLLNDDEEEEDYLFPALRRNNQTQEQELLSEGDIEAFNKLALEHKEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAJ6</accession>
    <name>A0A367KAJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000165">
        <property type="protein sequence ID" value="RCH98861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAJ6"/>
    <dbReference type="STRING" id="86630.A0A367KAJ6"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="77"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="30245" checksum="6395DF4E7A5C5674" modified="2018-11-07" version="1">MSLQQLQALRDQLRNEMNTPSPNLQLVGQLLTQAKVLLIPLGAFTPTIGKINVDSMTTARDILEIGAYYSVRVKDIASFERYIAQLNTYYHDLSSQLPPSQQMYPLIGLNLLRLLSQNKLSEFHTTLESIDLDQLHSNPFIKQAVDLEQYLMEGSYNKVWSARGSVKGEEFTFFYDILMNTTRHEIANCSEKAYEYLPLNDACTLLFLKNTEELLSFASERGWKLNPAEQKVYFTTEDDSVVEIPQEQTITRTLGYAKELERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB01</accession>
    <name>A0A367KB01_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000125">
        <property type="protein sequence ID" value="RCH99423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB01"/>
    <dbReference type="OrthoDB" id="2288107at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="255" mass="29504" checksum="B00764EE37EE2129" modified="2018-11-07" version="1">MKQKVDHTDESTSWDIESLEDLLDAWHQYLNESSNKHEYCLEKHHVIECGYSIKRNPTIPEEVYNQVGLSKECTIENPLISCIKFSSKVLDYMKAKSWKGVEAAVIGSQDEKLELLEFLPGEYLLKSSQEKYNADGCIIDDEGNEVFVLETSRKLMLNEKWEYGYDHVKCTFEDSLHLWVLELYFNKLYISNKAFKCKIPENMKDIKNVLALGNLLWCLKQAPKQKPVKGEGYGILLPEEKDENDCSVRFTGISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB65</accession>
    <name>A0A367KB65_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_004383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000122">
        <property type="protein sequence ID" value="RCH99455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KB65"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="577"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="937"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1343" mass="155641" checksum="5863752FBEEF0062" modified="2018-11-07" version="1">MLKCLSNRIVIRQYRRCFSISSCRQTQEILSDERLKELVAELQKPLNPEDNSTVVLATMESLRPRQKVITTNEYQKLYTLLNKSYNKHQLAEYLASKQMYKKNSTKRSMLATILQNTWGIKTREQVREERKKRIIEQFPASRQELFFIIGDNGSTIRKIEEANKVNVTIDVTQSRYLIEGQPSAVENAKRDIQGHLKLVEGQVQVPIETLEDSRFRSEISRVLAGISKVSGSYISLDNDKFVFTSLSDHAMENAKRLLNLTLTELNMTSKKPLEQANKILVDQGSEFNLVPFHDSLAMPMYDRQFGWSRLKKKNDSENKEPNLINLADQQTMQMSDIKELLLSAFKQEEYKDISLEAKFGHLLCRNSIKAQMTPNLLQPISTSDINISSLQELIKSNQTTFFNAMPPAKLASDFIPSISEGGVHQKLIKAEYVNNELLMNVDNNDQPKDNDMLNRLQVEFIVQENGSMKFNRAIGEKKRSVIDVLGLTRQVKLIYKFIDYSAEDLRQLFEKFKLLSYSEMVAPLHYKDMTLLDVSHINKKRYLYTDDNLIYINRVQEQDKRTRRTEVEEPVVTDVPQQREIEAATIEKLIEKMTVSLDYAFMTDFFLIYRIFMTPIQLAKFLISRFMWGLENDDEERCVTRVRTFVTIRHWLLNYYLHDFVPNKELRIILTKFLNEISLHPVIKQSPRDKRIIKTLKRVVRRLKRLYYTSSTDVQVIEPPPPTFEQARVTEMVKDKLSKNTIRQRIHGIHVDRRHRANTAIRDKQTAPVVVIGSTRYNSTATPLYQTSTHSRSASSLPIDESNYMNRTGRDRNEHDSDDSIGSYLTPGTSGIEDEEEDEEDEEEEEEEQEEQVQKDDMTEQLNQRLMEVRLLQQRLQQEQAREDAALQADLSLQEQQKLENARIRRSFYNAQLAIPSISSPSSDNLTPIIDGPARDYFDPELNTSKRQKEKKKDSLYSNRINKPLPPISTGPSPAASVRSYFSHKVDNQSKEQWKFAIKNKHSDKSLRSRITEMDIPPNNASSRSNNNYQSILLSYPTSVIAQQFCLIERNVLLGISWEELVDVRWTKMPAGLHLPSEFYNDDDSDVSGEQFNQPGIYSRKRRMKQQQEREKDYSERGVEKAIHRFNAVCQWVSSEIVQTGPIETRAKLIEKFIRTLIQILLGLQSSSVSRLEKTWSMVSKREMKVLKELSTFTSPTKNWKNLRDSMTQVAEEYGETPTEIQVENMGKNAITVKLPFGGCIPFLGIYLSDLVFNAELPSYIPSNYNPSAFQSQLEVTVLSQPLIHFRKHRITASIIKKVLIFQALAKRYSFVENLNDKLYLTCLQVPCLETDEIQKRSYQIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBL5</accession>
    <name>A0A367KBL5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SDAD1</name>
        <name evidence="11" type="ORF">CU097_014455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000119">
        <property type="protein sequence ID" value="RCH99499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBL5"/>
    <dbReference type="STRING" id="86630.A0A367KBL5"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="63"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="520"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="699"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="748" mass="85819" checksum="C2EED472C026F1E5" modified="2018-11-07" version="1">MGRRNRTALLPTHLPQLQNLIKRDPKSYEAEFLQQWRHFQSALSIFCLKPDEESKEVSDLVTFISQVAQCYPEITKDFPQQLVDLLQEHHMALHPEVRKSFVQGLILLRNKSILDNTRLLPLFFTLFKCRDKQLRELLYSHIVNDIKSANAKVKNNKLNKTLQSFMFTMLESATKGNSDENAIAAKKSVDVCIDLYHKNVWNDAKTVNVIAEACFSPVTKISVTAVKFFLNSNETNDDDENDDDDIPDLKKMQMANLHSKKTKAKDRKLEAAKKKIKRKSKSKDKAEGFNFSALHLINDPQGFAEKLYSKLSTKEDRWEVRLMKMNLVSRVIGIHQLTLLGFYPLLIKYLQPTQRDVTMVLVCAAQASHSLVPPDVLEPVLKAIANNFVTDRVANEVMAVGINGIREICVRQPLAIDATLLQDLTQYKQHRDKGVLMAARSLIALYREVNPELLLRKDRGKSASIRLKDGAIKTVQYGESITNVDALDGLELLDQEDKEEDWGDWEVEEDSEEESDEDGWINVASDDEDFVNVALSDDEKDEEEEEEKKKKIQYKIGENGEIIKARRIGKRQLKKLQDAEEHAEMSEEQRQKLLEAVRARQAEEKAKQEAKLKLATTRILTPADFARLNELRANKELEVATGKKRTFDESQHEEQVDEATILGPRKKTKQDYQQRMASIQEGREGREKFGSKKGKKEKGSTTNREKARKKNFLMIAHKQSVVSKSKRSLFDKQKQLRAAINKQKRLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC26</accession>
    <name>A0A367KC26_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">METAP1_3</name>
        <name evidence="13" type="ORF">CU097_014444</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000109">
        <property type="protein sequence ID" value="RCH99649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC26"/>
    <dbReference type="STRING" id="86630.A0A367KC26"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008970">
        <property type="entry name" value="PRK12318.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH99649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="39365" checksum="F78FAE6269B78C00" modified="2018-11-07" version="1">MLEKRICAFTDCQNEAHLQCPTCIKLNKTEGSFFCSQDCFKKSWGTHKANHGNHKEPYDPFKTFKYAGPLRAVYPLSPRRQVPPEIQRPDYADTGIPKSEFMAKRSEIRVLNADEIEGVKKACQITREVLEIAAKAVRVGITTDEIDRIVHEATIERGAYPSPLNYNYFPKSCCTSLNEVICHGIPDQRPLANGDIINIDVSCYYNGFHGDANATYLVGDVDEAGQKLVKVTRECLDLAIAAVKPGIRYRDFGKIIEDHATKHGFSVVRTFCGHGINQLFHCAPDVPHYANNKAIGVVKPGHIFTIEPMICEGVHQELMWPDGWTATTKDGKRSAQFEHTLLVTETGVEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCH6</accession>
    <name>A0A367KCH6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000092">
        <property type="protein sequence ID" value="RCH99905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCH6"/>
    <dbReference type="STRING" id="86630.A0A367KCH6"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22943" checksum="C7A8974B0EF8536D" modified="2018-11-07" version="1">MSSSAVDIELLSDDEALFEELEKEEDSEIAFMREQRIKEIQSELARRQTLEENKHGVYTEIFKEKEFMDITVKEKYVVGHFFHQDFRRCKIMDTHLEVLAKKYYDTRFIKIDVANAPFLVEKLLVKILPCVIAWKEGYAQTKLVGFDDLGNTDNFTTAALELKLKHAGVIKRKEDPVVQVKKSIFQSNDTDSELEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD51</accession>
    <name>A0A367KD51_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SPO14_7</name>
        <name evidence="14" type="ORF">CU097_014777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01000080">
        <property type="protein sequence ID" value="RCI00107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KD51"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="299"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1566"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI00107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1588" mass="179671" checksum="7DCE843F5006DC9B" modified="2018-11-07" version="1">MAYISQIAADTDDLNNGRWHTLLRKMSVIATPEQSITGTTETLEKSIVEEVNLPTVEECLDQEDYETAISYFETDSNTLTDHRSSSSIYPSDNTNKVKQRWMRSFEKIRMINHFKSAPSSGTGVISKLPLAPYYPAAFIPLYLTLLSKDEHGRKPPPILFDALSCAITDSIIDQNTSHRLWTFRIELQYGEVKWVIHRTIIEFYNLHLTLKFKHISGLISEPPPSFPSQLAHLTNAALTSMRIVREEEDDRWQDVALKRRDDLEFYLKELIEKAAVTVNYELCEFLELSAISITKDMGWKGKEGYLEYSTAPISFRLGLPWQQKWQKEWLILRDSYLAFCNDIGSTSVTDVLLFDRHLKVRLKGQGSTTFGSVHFIISNSTRKIEIKSPPSRYTDEWLESLERAQKESPWAMNQRFGSFAPLREHAKAKWFVDGRDYYEAVIHAIISAKSEIYIEDWWLYLRRPPKGNEEFRLDRLLKRKACEGIMIYIVLYKNVSVALPLDSQYTKDWMQTVHPNIIVQRHANLTSSPFWAHHEKILVIDNRLAFVGGLDLCFGRYDTQAHELTDYDSTDISWEVFPGQDYSNPRIKDFQKVSQYGTELIDKTTTPRMPWHDIHTAMVGSPARDVARHFVQRWNFIKANRAKDRDDIPFLLPKGEYVATRDETKFKGTCKVQVLRSSAEWSQGIVREYSIYNAYMECIFKAKHFIYIENQFFITTTSPDDKLIKNKIGQAIVERIKRAHKEKQKFRVIVVIPSAPGFEGDFVQVDRRSMPLRSVAQYQYRSICRGKYSIFEQLKKDNIPIHEYIGFYSLRNWGKIKRPSSSPSAFLDGKRKRRTRSRSNTVTDEPNVNIQQNLYYADDGRMDYVTEQVYIHSKLMIVDDRIVICGSANLNDRSQLGNRDSEIAVIIEDTDTMDSKMNGEPYKASSYALTLRMQLFKEHLGLLDTSASDTFDHRRKENRIVMDPLDDEFYFNVWNKIAEKNTLIYRELFKCVPDDTGKFYPVLIKICIESFFSCKFILSSNIVSLYLTQLVSYRDISPNHGNIQLKKMLKSFESLFDIYTVYVQHPVISKWLAFVLFLSLFLNTYLLNITKQQQQQQQLKQEQQQQKVVAEPVSTDTPQKPVTKKPVKPKRKHHHHSDIVRPVEEILGLLATPDALSDEEIISIVQAGKLAPYALEKVLGDFERAVIIRRALISRASLTKTLEHSLLPVANYHYDKVMGACCENVIGYMPIPVGVAGPMNIDGELIHIPMATTEGCLVASAARGCKAINAGGGAITIVTADGMTRAPCVEFPSITRAAECKQWIEHEGKDIVAEAFNSTSRFARVKKLKVAIAGRLVYIRFSTTTGDAMGMNMISKGCEKALSKIEEYFPDMQIVSLSGNFCTDKKPAAVNWIEGRGKSVVAEAVIPGPAVEKILKTTVSALVELNISKNLVGSAMAGSVGGFNAHAANILTAIYLATGQDPAQNVESSNCMTLMKAINDEKDLYISCTMPCIEVGTIGGGTILPPQQAMLDMLGVRGPHPTEPGANARRLAGIICAAVMAGELSLCAALAAGHLVKAHMAHNRNTQPISATPPATPAEPVPGSCIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDY6</accession>
    <name>A0A367KDY6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000065">
        <property type="protein sequence ID" value="RCI00351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDY6"/>
    <dbReference type="STRING" id="86630.A0A367KDY6"/>
    <dbReference type="OrthoDB" id="2209126at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="13821" checksum="EB9B9C20A371B1B4" modified="2018-11-07" version="1">MPSVTTATTNTTTATATINTFGDTSVIPTAVLPDNNIVYLDLTCNRQGHDQDDEDEDIVSPSTHDYAETMLYSFVDNSPHVADLLWSKQQLGQSAFLKLAPETNEELVLEIPHPTPSISTHDICLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEP7</accession>
    <name>A0A367KEP7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MSS4_1</name>
        <name evidence="14" type="ORF">CU097_002729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000045">
        <property type="protein sequence ID" value="RCI00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEP7"/>
    <dbReference type="STRING" id="86630.A0A367KEP7"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="129"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="61672" checksum="501F76275C80F0A1" modified="2018-11-07" version="1">MPTSQSVRSGKSVPESRLSKDHKEPIPVNPNLDTHYSTRRMSEDVAPFPLDPNPSFVSQTKRASSTPTLSRHRRTLTPDLGELGPEDQAALEAEITARRAARRASRRIQHKYDDDDDDRVMIGTRVGEGHRNYQLMYDMLTGIRIAVGRVSAKIRRDLSDDDFKAAHKLVFDVTGNELTPGVKYDFKFKDYAPWVFRYLREQFHIDPADYMMSLTNKYILSELGSPGKSGSFFYYSRDYRFIIKTIHHTEHKFMRKILKDYYQHVCENPHTLLCRFYGLHRIKLPHGSKIHFVVMGNVLPSNKDVHETYDLKGSTYGRITTDEDINKNPHAVLKDLNWVNRKKRLELGAQKKALFLEQLRTDVQLLSRLNIMDYSLLIGIHDIIRGNTENIRDSNLRFVQPHTKELERTLSRNRRGSKADIVRRAIKLSNPVQLDSSLLPETPFEERKYCIFYSEDGGFKSTDENNQPTDKVYYMGVIDILTRYSLLKRAEHALKSLTQNKDTISAIHPKMYGERFIAFIENLAVINYKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEQ1</accession>
    <name>A0A367KEQ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SNF8</name>
        <name evidence="10" type="ORF">CU097_014515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000050">
        <property type="protein sequence ID" value="RCI00611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEQ1"/>
    <dbReference type="STRING" id="86630.A0A367KEQ1"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="253" mass="29096" checksum="1056B7EF6E3182E9" modified="2018-11-07" version="1">MRRRPIGLANARHRERLDRDYQQIGDTIAAKELQQLQNQMETFKKNLQEFAQKHRKDIRKDPTFRAHFQKMCANIGVDPLACIGFWADLLGVGDFYYELGIQVIEACITSRPNDGGLTELGEIMKRIKAMRGAPSYDSKKGNAQQQITEDDMIRAIKTLKPLNGGYEVLQIGDKKLVRSVPKELDKDQSTLLLLAQKTGYITYEMIQVELGWGQERMNTAVNRLLQDELAWIDSYEGVDTYWIPSYFMSRSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KER7</accession>
    <name>A0A367KER7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_011362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000044">
        <property type="protein sequence ID" value="RCI00715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KER7"/>
    <dbReference type="STRING" id="86630.A0A367KER7"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="676"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="110653" checksum="FE8746AF184F8D38" modified="2018-11-07" version="1">MTLDSPTKHTLLCSKCDLPLGDQLVKALDGAFHPNCFTCWDCQTPVASCYLPHPTEPGKPLCERDYFKRLELVCAECDEPLRGTYIIALDKKYHPNHFTCSDCSTVFGPDDSYYEHDGHVYCHFHYSTRFAVSCAGCDMAILKQYVEIERGDAVDHWHPECYMIQKFWSVKIAHPTLKEGDQCPPKYIPQTPFELLKIQKDTEEKVVSIWSVLSAFEESSAVCISEMLLHVSNGAYIESICLSERFLVHVEALFAGIDKICVIYKEHQQSEFKYSREAKMLCKKIINFFSLLSRTGDMEMKKLGITQELLSLVTGLAHYLKNLIRVTLNAALRLETLLGKSVAVSHLLARLMEIPGKERHSRDSQRLIQAKNTDYCQECKNIIEDQCVRYGDQRWHIACFQCKKCERSLTTTSGSVMNGQLYCTTCVHASPCTFDYVSRLAQYSYLLRIALSRLCSLLQITDSQLSNVDYSTKLNSAKAAASHILKDMPPNMLNASIELQQMMEERGHMETIYPTEIKDAKTVSSSTTRLDRKMSRSFKMANKRSTILGNTTLPTRTDSLHRRSVGLDDLPQMAAVAVNATTTNSRKAPPENIHIATGLSGKPRIYLSELSALQYMIIRYVAVVQIESYVRSSFTSAELLNMVETKKSSIWGKFFTPFKVKKNVQPKAKEIGTFGVPLDVLTDRTGVESNLALGPSPVRLAAFIDDAITAMRQKDMSVEGIFRKNGNIRRLRELTEALDKNPNEVDLTQENAVQVAALLKKFLRDLPDPLMTHRLHGLFMCADRIPDPDQRKRALHLACCMLPMTNRVTMEVLFLFFRWVATYSHITDEVGSRMDIPNLARVIAPSILTAHHKDPLKDESFTAIRVVETILESCNEFCLVPEDLEVFLKDPSLSGMDMSPREFLKKVEQTVKHKGYSIPRSPDAQRPPPSSIYTPQQYLPYSNHHPPSDCIPQPLKSTPQLMQPPRRTDSFSNAYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFD6</accession>
    <name>A0A367KFD6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000036">
        <property type="protein sequence ID" value="RCI00877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFD6"/>
    <dbReference type="STRING" id="86630.A0A367KFD6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="236" mass="26754" checksum="8B141E6B442CACC1" modified="2018-11-07" version="1">MGNCFPVAHRAQPISDRNIISQEDTFCNTMTAYKENTTIMNSTANTDRENVLPSVTDALDLQKGIDILDVGCGSGVWIMNMVQEYPNCTYYGCDIADTRDKSMDVNQYTFSKGNVANKLPYENNTFDFVHMRFLVLALREDEWPAAIKELIRVTKPGGMIQLVDFELHMPKDPSNYFYKVMSATKEICESRGQNPYIGAELNDMLSKQDSVKVVQYESKDCDMSKYGLGTRKVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFX7</accession>
    <name>A0A367KFX7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DIS3-like exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DIS3L_2</name>
        <name evidence="6" type="ORF">CU097_015822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000043">
        <property type="protein sequence ID" value="RCI00742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFX7"/>
    <dbReference type="STRING" id="86630.A0A367KFX7"/>
    <dbReference type="OrthoDB" id="2251664at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF30">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="379" mass="42722" checksum="30D59465D1A0B8E5" modified="2018-11-07" version="1">MEIHGLVAEAMILANASVGKRIYEGYKDAAILRHHPPPSPAQFEKLVKAAESKGFSVDFSSNRALSQSLERITDACKDDPEIAKLLKTMATIAMNEAGYISSGQFPVDQYYHYGLALEFYTHFTSPIRRYADIVAHRQLLMCVADPTALKNSVSQSLMFKDSAITDICENLNRKSRESKFAQRDSTELFQSLYVLQKTANGDPLIEKGIISEIRSNGFYVYVPRLGLKGPVYLKERDGTPSVPLSLISGKNADEQETIPHCNIEVNMPTSISVLSPDLPHPIQFNLFDHVRVSLKLRKSHAHRHLVYMVLIDMDHTEIRTSQPSQIARMSNTEMMESIHDSERKGNAEKEANKKKKNKTSSMYDVLERFRKLSIIQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGP3</accession>
    <name>A0A367KGP3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGP3"/>
    <dbReference type="OrthoDB" id="2263744at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="128" mass="14071" checksum="BCF3F2B718B0AE3A" modified="2018-11-07" version="1">MPSSVRGLKPTVPVRLKEQVQNLYKQFEIHRRQFVCTSCQTMDSLYRNGTSPGDPPHPSFIYKCCNKNYNAPTMVNLLLSASTTTETLSDANAQNSLEISGSSSPGPENNGLASSVTIEKLYAELKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHF2</accession>
    <name>A0A367KHF2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_015697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000017">
        <property type="protein sequence ID" value="RCI01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHF2"/>
    <dbReference type="STRING" id="86630.A0A367KHF2"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="599"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="790"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="121206" checksum="60367E4035901F6D" modified="2018-11-07" version="1">MADNETKSLIIESNISNKPSNMTRQNVFMIQYSMKVINNNTAFSTFKQELRYPRSVLTFKILGKIGCIQHCKDWIHYVDHVSNDLGPWCSDILWSILLNDINPGSNDFSANDFVLLQQAQIICRHTFEFSTFDYRNTELFTPKVTQFINCLISLTSSKWRLFTVVIVENRITALVLKLLISSLDALRTDAFENISETTEGPIPRYKANQFNLLITTYELEAVAITELYDYLIRFDFYKDEIMYLASTATRRLSSKTIMLINAQDKREMRLANKVAQLEGRVANVHHFSSSSTDTQMSSCLNKTNVTEMQIAKVQVGSYKQSCVKFWESDIVAKMEGLAIMNLENEETSVFWLSAFEIEQPEMHTRKIGFCTKKPLPDLPALEFMLDNTLHKFHVRNFHTCVHLEHSVSDQLLSYTLQVTNHLKKDNITCSLDDVPYLLVPLKQFCNDQSHNVDVDWEEIEKTIRYSTKRTVLSTDFPISDTLIYDLEKPNHVFLIQDMSVSIKPMFYLFRDEEVDDQEKFVFTEFYKSRLQHISKMDFSKPLIQATLVKRDSKKSSCLFPLYSRVWLIPDYCAIYPISASVYRAYELLPEIMTQINAYLLVLQAKEMYDFKKIDDALLREALSCKNADFIKDYERLEYLGDAVLGFIFSTYLYIKYPNYNECQLTNTRSRVVKNSTLAQAGKNIRLYKYIINQKMDRDAWQPPAFVSCYKKRKSIGFPYQTTRRSLSDSTIADVMEAILGAAFLSHCLDGALHTATKLLLPFDGLKTWSDMSELCSKITYGEKSSYNIDLAEFYQKIGYTFSNPILAEKALTQRNCKISLQYERLEFLGDAVLDLFIAQYLYKKYPTAHPGELTSLRSMYVSNATLAFICIKMDLQKHIRHSSPEMAMNIAYYENQLRENAMKEKNDSDFWLSLDPPKVLADVVESVIGAIFIDANCDPQPAYAFFEAWLIPLVDGYVPGMAFPVVKFQSAIRGFRCHEWELRQSRPLQHHNTCLLIVHGQAFAQGLGRTKKSAKKSMEVNAVQKIRQEPEVFKSLCSCRKNLSHLEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHK8</accession>
    <name>A0A367KHK8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHK8"/>
    <dbReference type="OrthoDB" id="2267423at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="101" mass="11525" checksum="A6DEB3027FC92397" modified="2018-11-07" version="1">MNIIAPCPQKPSRYNYYAMGDQTDEACQELRQILASSNKMVEELSIARTNNPMPNDTSFIIPNIQQSNVNEDRHRPRSFSMGDTRAHFISQAKFVVSNLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJZ3</accession>
    <name>A0A367IJZ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005493">
        <property type="protein sequence ID" value="RCH77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJZ3"/>
    <dbReference type="STRING" id="86630.A0A367IJZ3"/>
    <dbReference type="OrthoDB" id="2289822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19704" checksum="3D703532E6BA7718" modified="2018-11-07" version="1" fragment="single">QLWEPRAYYQALGNGRICAGLADADVFRALLSYYRRLAGNRSLASINSDIKIAERLWLNSIIVSSKLYRTRSRQTTRADNFVMFESGRYRSNRQCWFVGEVHCYLVHRQDDQERFFAVMDVMKEHSIDNYGVPHVTRDNKRQFIAVASVYDILGCVGLVRYSDNTNNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILN1</accession>
    <name>A0A367ILN1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005180">
        <property type="protein sequence ID" value="RCH78421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILN1"/>
    <dbReference type="OrthoDB" id="2284024at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="10395" checksum="3310DA70FA19BC4A" modified="2018-11-07" version="1" fragment="single">ATSKTQDLLNEVGQTSGPGSINNATQTTRRRTFGSVSSTDGSELSSGLTNEPMQFGHQANAQLMHSITEDIAAMHSRDPDRFGIVASKFDEAFGQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IM30</accession>
    <name>A0A367IM30_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004951">
        <property type="protein sequence ID" value="RCH78734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IM30"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="17991" checksum="A3ABEBD38F70D37C" modified="2018-11-07" version="1" fragment="single">LLSDTVDHYTSMFERPSETISKEMNIKFAEYQLHESNCLLSSITTENCLYYVLLQNPQKSDFSNQMPQYACISIANGDISDAKFFDDKELGILVKTGQDTTILYTLLLNQISYQRSELASIDLETHHERHLLLSKMIDVNMGCNGLPNRRIFATVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMG0</accession>
    <name>A0A367IMG0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPL11_1</name>
        <name evidence="8" type="ORF">CU097_002543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004871">
        <property type="protein sequence ID" value="RCH78855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMG0"/>
    <dbReference type="STRING" id="86630.A0A367IMG0"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH78855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="146" mass="16840" checksum="1EB9902FB9E1D828" modified="2018-11-07" version="1" fragment="single">LTRAAKVLEQLTGQTPVYSKARYTVRTFSIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELKARNFSDTGNFGFGIDEHIDLGIKYDPSIGIYGMDYYVVMGRPGYRVSRRKHCKAKVGVTHRIKKEESIEWFKNRFDGVVSNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INU6</accession>
    <name>A0A367INU6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004573">
        <property type="protein sequence ID" value="RCH79316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INU6"/>
    <dbReference type="STRING" id="86630.A0A367INU6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="62" mass="7218" checksum="3AC6DD53186FC5EC" modified="2018-11-07" version="1" fragment="single">RAEMSISDHEKEIEGIKKEIEASNSIVQRLQSKVTEAHAVRDRLLNKVKDLEESKKVRRETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPM4</accession>
    <name>A0A367IPM4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004385">
        <property type="protein sequence ID" value="RCH79628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPM4"/>
    <dbReference type="STRING" id="86630.A0A367IPM4"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="8784" checksum="E3B55B4D18614A91" modified="2018-11-07" version="1" fragment="single">MGQDNWSSNKYVKHAAFVPRLGSVILDVLDPQPHEHILDFGCGNGILTRELAGRCKSVVGIDASKAMIDGAPSVKNVEYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRI0</accession>
    <name>A0A367IRI0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004005">
        <property type="protein sequence ID" value="RCH80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRI0"/>
    <dbReference type="OrthoDB" id="19659at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="63" mass="7417" checksum="87329962AC230654" modified="2018-11-07" version="1">MEHLSQIDEIKRIEQQKDQSIAAAVIQNKQPTIPKAVKKKKKARQVLLEEEHSSDWKPKRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRU0</accession>
    <name>A0A367IRU0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RHO1 GDP-GTP exchange protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ROM2_1</name>
        <name evidence="4" type="ORF">CU097_000346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003952">
        <property type="protein sequence ID" value="RCH80372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRU0"/>
    <dbReference type="STRING" id="86630.A0A367IRU0"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="3">
        <location>
            <begin position="196"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH80372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="513" mass="58063" checksum="BC92F188F25808AC" modified="2018-11-07" version="1" fragment="single">KTENRFNLQLLDERLINKHISSLDLDLQADNRQIIMKGTWKKGSGPESSDVLVYLLDHCLLIIKPKQNEEKYKLYRKPIPLALLSISFPDQTKRASTIIPLGRPSNVSSCPTDTVQNNATTISSTTSATNHNNKNGYPISFVHLGKQSSGPMTLYAPTLAGRKQWADKIEGQRRALVEKHKVFNVQPINESFFSAFNKVNCIAVFENGKSLVLGGDQGVYLKKEGSGDELIRILAMDKVSQIDIIEQSNLILVLADKILYAYSLDTLLSTETGIKRGRKISSHVSFFKVGKIWDNAMSCTIHALEPYENTESKKKHKHKNFGRLIRGNNEAFKVYKDLYMPGEASSIQFFRNIICVGSERGFLMVNLSSAEVQSVLDPNDDSNNALLAQHEYMKPISMFRHKDGNILLCYNELAFYIDKKGKRVRKDWCISWEGSPTAFSFRFPYVVAFNTNFIEVRHIDTGDLLQVIPGNNIRCLRPDSTDRIHGVMDDRLAGSEVIFELKLVDPHRRKISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITA1</accession>
    <name>A0A367ITA1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003689">
        <property type="protein sequence ID" value="RCH80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITA1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="57" mass="6414" checksum="8D26D1DB8A929606" modified="2018-11-07" version="1" fragment="single">MAKNRNTRHSPDSNSDVEDDDAVIKSAKYISWVRGSWFPPSRSNSKVYDGSLPAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITA4</accession>
    <name>A0A367ITA4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003695">
        <property type="protein sequence ID" value="RCH80866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITA4"/>
    <dbReference type="STRING" id="86630.A0A367ITA4"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="2">
        <location>
            <begin position="110"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="485" mass="56594" checksum="B60FD4D019646F5F" modified="2018-11-07" version="1" fragment="single">MSSLIPPSPSRRRRYEALKQISWTLDNAENRVTQLDASGTDETASEDDMIVEYELVDEQNYIAYQELEEDEDMQMTQEIKDDDVDMQLTQEITYNKPVKDAVMQEETMTTNDKPSLEDSEQTTLADFLEMAGITFPRQIPLNDIIPISIVDVDYESPTIAEQAAAAAFTLPQIDMYDSISKQMHSLIDASQDVIQKVEDRVNRTSTEFFSDYLRANASTRITMEPEYRLTKQYAELKSLERWYEWCVNIFAEHLGTLKGHINTLTQDRQTLASLEDELRGQLPKIVEYQQGISQLLAEAHEIEKEYRRFDHKKLSRMRDEIEHQRQTIELFNKDLENLGAEEAELFERIDMLEHRKSRLIKDIVDAREITSVNHIITENDLNQVRQLYERSCNVGGLRLLKDNEDDDTLEILVAKCLVLTIYRNDLKERKEDAVLFHIKNNKINGYEYIAHFRRGLSAIVKSNQDTNQIIQEITTYWNRVQMLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITM8</accession>
    <name>A0A367ITM8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002282</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003611">
        <property type="protein sequence ID" value="RCH81037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITM8"/>
    <dbReference type="STRING" id="86630.A0A367ITM8"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="444"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH81037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="504" mass="54953" checksum="AB6B1E8F5FCC1F59" modified="2018-11-07" version="1" fragment="single">SGFGGLILSNIVQAAIDHVGYQWALRIIGFISFVCLGIASCTVRPLNEPSKQENVKLMVFDLRPFRNKQFILLFCIQFVGNFAFNVPSSFLPAYANYLGLDPWIGSNMSAIISGVMIVGKISSGFISDFVGRANMTFFVTTMTGVMCLAVWLPAKNAAMIWAFAAMFGYFGGGHLTMVPALLGQIVGMDDIEAANGMLFFAWFFGGLFGSPICSTLINDGSDHPTYSHAIIFSGVLMIFAGLLAWAIRVMRAGWNPVAWLIAFIGACVFRVGVSGGAWWIIVYELLIIIGVTCILVTNTFTHYRMMILAFLGASISLLTMQLDYITPASRVFGGGAGAFATGYIILIIIQFLWVMIFGSDPESYIGQYGPSHYGNSVGIQHHRQQQPQQQQQAYEMTGEKTILSDPPVQTATTPTTAPATIQEPNTALSASNQATEMPQPSPVEYREKVKALHAYQANPDDPNELSFAKGEVLEIVDRNGNWWQARKADGTVGIIPSNYFAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU81</accession>
    <name>A0A367IU81_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003547">
        <property type="protein sequence ID" value="RCH81179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU81"/>
    <dbReference type="STRING" id="86630.A0A367IU81"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="120"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="688"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH81179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="87614" checksum="D56B6FB5AA259747" modified="2018-11-07" version="1" fragment="single">ADTTDPLSKLTAICRQGFPLCKLYNALNPTEPLSVDTDPNLNARNSCKANVYHFIVACRDKLLFPEEDMFTISDLYQDDTNGFVKVVHTINKLLQLLEERGLIVVRSSNRNSDPNAPKNTRDKVVLELLETERKYVQDMEILQNYMRELQSQKVISPDTIHYLFGNLNALVDFQRRFLIQLEEIAEKSPQEQRIGNLFLQMENSFSVYEPYCANYYSAQDLVVQETPRLMKLADILDPTYQLPSLLIKPVQRICKYPLLLQELVKSTNKDFPYYYESLEAVDAIKRVAEKVNETQRQHENVQAVQELKKRLDDLNNLPLDGFGNLLMQDKLFTMTADNHERELHAFLFERTLLLCKESKGNNILPTNTLSKKKRRGSLVPKVIADAGCISEMKSQCNKNGVWSMSIRLNEHELKQLSIKFRNEEQLKLWSAALIKVQKKALESEAELLSMQLASRTYDDYDEEDLYGDEDEEDYHSTSTTTTSTTARSRSGSFSSHHHVMVPPLILKASQSTSVGRPHQNVPGMNLSPLPRSNSSFSTVSQNHYNYYPVSPPPSHPSSPISSTTRAVNTNAFCWPEDNIPELPSEAFVQQHLHQHTLAKTGRSKSQPSGESKNQQSPLPNNRLRSQSSPNLMKNANTVSQIMESLPPLRQSIGKPSEPEMKPSTSTRLADIVMTPSSTTSTPTSSSGAMKVKLNFNNNIYVIVTNQNITFYDLMEKIDRKIRLIANLKPTDVLRLKYQDEERDFITINSDDDVQMAFEAGGSTNTANLFVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUR5</accession>
    <name>A0A367IUR5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003471">
        <property type="protein sequence ID" value="RCH81359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUR5"/>
    <dbReference type="STRING" id="86630.A0A367IUR5"/>
    <dbReference type="OrthoDB" id="415359at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="389" mass="43976" checksum="D867771FED9C4718" modified="2018-11-07" version="1">MLSNQSVEAAIALLLENRAKVDAHIPLRRSIQTTRSRSNSSIENKRHSLQRASSLGNTNKTGKSWNPISFLQQQKHAMENTHLSSVRKLGGWLGKAMENLGIEEDKPKPAPPLAESFTIMMGTAQVKSTHNLRLLVTDQVIPCDPLRDVAYRAETATKLYTSHLSATVVLVDLNDLRRQDQPAGYGWRQYKAGKAGNQSLFERCQQSTEFHFADIETQLSVIQQDFECHPEGLQEGSFFVTKHSNLPNIQVVFHLIIDSTSISTLDVSNRHSLILGLRSILKLTSQYDISSLSIPLSLLPDKFLVQPEQIPNYQLWLQKRGEVVMKCIKGYLIEHSQSGKRVLQEENNLGLRTIEFILPPISNHMDDVSQQDVLFQQFRNLLVNLFRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXH3</accession>
    <name>A0A367IXH3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_005289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003034">
        <property type="protein sequence ID" value="RCH82378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXH3"/>
    <dbReference type="STRING" id="86630.A0A367IXH3"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH82378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="42479" checksum="E786386853FCFE70" modified="2018-11-07" version="1">MTCSSFKVPIGFPIFGLAFTSNGQLVVGGGGGAGRSGVKNKLSLYKIDTRRKDLEEDASFEFSSEEDAPMSLDVHPKESMVITGVNSTESNIKQGSNDNCRLFKILDDKLELQKAVNTLESKQLEDYQGVVRFSFDGNLVATGTTDGKVHVFNYPELEPLCMALLTNNGEVLDVDINLEKEKLICVLSQELKLINLRNKKNLGKVVQTISYPLKNSQGEFRAFRYGRGFTKDVGFAIVNDKKGAYIVKYDAYTFEQLKMVKVSSKPITAVALSQDGAVLALGCADLTIFIVDASSLRTLDRIKDAHSFSITCIAISPDRRVVASGSADNTCRIITLPLQFSQTLPINPLHTLMLALLVAGILLWLTTLIDIESYFNRDNLVQERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYT3</accession>
    <name>A0A367IYT3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002875">
        <property type="protein sequence ID" value="RCH82840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYT3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="8866" checksum="D57FECA392E8BD4D" modified="2018-11-07" version="1" fragment="single">HMLVSLYLIVQYIILHPRSGLIFSPQINAPLDKIPYEHSATSHPSSGIIYYFGGRNCDSKDYTTVASLRWGLYLIPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0L3</accession>
    <name>A0A367J0L3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002649">
        <property type="protein sequence ID" value="RCH83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0L3"/>
    <dbReference type="STRING" id="86630.A0A367J0L3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19478" checksum="F97A814380AEB24D" modified="2018-11-07" version="1" fragment="single">MQQVNGVPIYSDDPNLYFEGLNTQPTWFSAQGGVYKCRELSTNREVAIKKYLVEEDSQYENMFVMPKELVENEIYSMTKCVHPNILELLAVYLHQEFVYLIMPLCTGGSLQQYVFEHHLTVGQLVYIIRSIASGLAKLHEYGYIHRDIKCDNIFLNQQDNSIVIGDFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1Q9</accession>
    <name>A0A367J1Q9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002560">
        <property type="protein sequence ID" value="RCH83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1Q9"/>
    <dbReference type="OrthoDB" id="2412252at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="365" mass="42846" checksum="DD7BFD29C11DB023" modified="2018-11-07" version="1">MSLYSNEQEIPVTCTPIFEGHLYVRTEKKEWKWRLFRFDGSTFTCLSTKRQPNSPTVNNPLYTTPKRLTDELIPNIKYFQLPEWTVDLSTICSISLLRKSKRPPKCFSIQTIFNKRYVLKASKQKDLERWLFVLTKMWTFTQQQQQQQQQQQEPKIQPMLKPMLSKEKIQVIEEWRRSLAELMAQDPNIKKTAAPPPIEPMPEDDNLSIFTDMTSISHRRPNKKVIKRPSTRRAKIMPKEMPLVTEANLILKKKGLDDAGLWMSNNLFNYFQQEKSEHLSSFDNNNNNNAVFVEKVKYYNFESGKKLIIQSQSNYLNYAKEEEEDEDISLAELLHKLNLTKQPSVKKCSSFVAPAIPPYKVSNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J280</accession>
    <name>A0A367J280_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWI SNF, matrix associated, actin dependent regulator of chromatin, sub d, member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SMARCD2</name>
        <name evidence="3" type="ORF">CU097_005862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002482">
        <property type="protein sequence ID" value="RCH84026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J280"/>
    <dbReference type="STRING" id="86630.A0A367J280"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="428" mass="49852" checksum="68AF526FF6842DFD" modified="2018-11-07" version="1">MQPSSLNTQSIQYRKRTEQDSIDNHIKKKRPVDRNIPPKIEANVPESRLYEELCQFERNMDTAIMRKRLEIQEALGKPNKVKRTMRIFISNTAADQLHQEEEEEEVDGQVFEINSENEPSWTLKIEGRLLDPLIPTKKAQPVQKFTSFFKSIIVELDPEKYPEGNLIEWRKQPSSVESDGIEVKRKGDTNVNVRIILVPDYTPQKFKLTPALSELTGLKLATKSHIVSELWNYIKLHNCQDAKDKRIIHCDRKMQAIFNATQLQFHEIPELIQRQVTQPDPIVLEYTIRVDKRFNMSSKAYDVDVELDSVLKQKMMNVVAASQVQKDILSLDDKIVQCVQSINNSKMKRDFLMQFSSHPIEFINKWIHSQARDIEAVLGETKVNLEDVRQTEFYKQPWVKEAVFHYLTSKTQQKMQELLATQSSAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J289</accession>
    <name>A0A367J289_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002474">
        <property type="protein sequence ID" value="RCH84053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J289"/>
    <dbReference type="STRING" id="86630.A0A367J289"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000005">
        <property type="entry name" value="GTPase-activating protein gyp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="54"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="397" mass="46489" checksum="04E78595C18C779A" modified="2018-11-07" version="1">MKRKQKNRRKQVKKRQDKIAAYENEEFKDIFRINQALRMKDYGLLREIGRQSGFVSDPVRRRVWPFLLHYSERKVKREGSLNIPHKDEEQVKLDVTRSFNTYPKNVDDQEKEKLQGQLHRVIIHVLRSYPSLHYYQGFHDICSVFLLLFGEKYACQLMERVALFYLRDAMFATLEPVMKQLTMIDSLIRLEDNELYEFIMEAGVLPYYALSWVITWYSHDLSDLEKIARLFDLILSSNPLMPVYLAVATVISKRKQVLALPCDTSTVHSFLTNLASDTDIDTVCEQAHALEARYGIYELQSLSTIPLDQFSVVNRFEQDYLSIDTLEKYNEKVSEVIRITRQEKYDKPIELTAIKPHEATQSTLNKLLMHKEIYTVFTIGASLSILALWIANSSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3F0</accession>
    <name>A0A367J3F0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase spb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPB1</name>
        <name evidence="13" type="ORF">CU097_006198</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002364">
        <property type="protein sequence ID" value="RCH84443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3F0"/>
    <dbReference type="STRING" id="86630.A0A367J3F0"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="26"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="236"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="634"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="821"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="729"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH84443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="859" mass="98952" checksum="A73BF3FF667BF72D" modified="2018-11-07" version="1">MGKGREKKHSKGRLDKYYHLAKEQGYRARSAFKLIQLNKKYNFLEKSRALIDLCAAPGGWLQVATKYMPQSSLIIGVDLCPIKPIPGVITFQDDITTERCRQNLRQEMKTWKADVVLHDGAPNVGRAWAHDAFSQSELVLVSLKLATEFLAKGGVFVTKVFRSKDYNKLMWVFQQLFRKVEATKPPSSRNVSAEIFVVCRDYVAPKKIDPRMLDPKSVFSDVGAEEPKKIADVFKPEKKNRHRDGYEDGDYTLHKTLDVMEFIRANDPIVTLGSYNQFTFTSDESKELLKKDITTEDIKINCQDLKVLGRADFKALLKWRTIIRDEYKLEQKKEQKIEVIEEEPLDEDEMLEAELTNLTKEEAAKRKREKRKANEKKMKLIQRMQLNMIIPTDIALDENKMDEEMFSIRKIKKDASLEKLQEGDMSIADDLEEEDGDINVDKSLKGRIAEMDMDETLDSDEEYERDLEMQMDEDYARYKQRRAEKDAKFRAKMAREEQDEWSGFDEKAKTTRDKKFDSDSSDSDDDSESDNDDTMDEASDSDEDDAPKTTMKGIKPRTQNSLMNDLGQKAALSKKTESGLSTAAAMFFDQDIFRDVAVDEIMDQDESSDDEEFIREQSRKRKREQQDDGTTERDEEDSDFEIQPTEDALPSDDEMWDGREDDNSKAMKEALEKGLTTPESITLAKQLANKEKTVEDLVDMGFSKEAFRDKDGLPEWFLDDENRHNKPNIPVTKEAMDQLREKLRALNARPIKKVLEAKARKKLKAAKRLAKAQKKATDIVDNPDMTEKEKAKTIGKLIARASKTKPKKEVKVIVAKGANKGIKGRPKGVKGRYKMVDGVMKKERRAEKRREKKLKKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3P9</accession>
    <name>A0A367J3P9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002334">
        <property type="protein sequence ID" value="RCH84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3P9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13148" checksum="63B113389F8116ED" modified="2018-11-07" version="1">MNDVCFLDLGLNTLLISAANISTPSENKHIGLWRDAQEYDHLDPSPTQLINYLADQRTTKRLKFYQVLCSNTIIPPEHWSYDVTPTIQYLKSWGFQFISQQGPVDGENLLASRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4R8</accession>
    <name>A0A367J4R8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_000075</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002222">
        <property type="protein sequence ID" value="RCH84954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4R8"/>
    <dbReference type="STRING" id="86630.A0A367J4R8"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703880" description="dolichol kinase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH84954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="520" mass="59257" checksum="452167ED3EE8F4AB" modified="2018-11-07" version="1" fragment="single">MVAVCFFFSFSLFLFTKLPGLINIRINKNHSQVKSSQQDADEGFASSSSIEEDQAFEVLRRKRINKKTIDETSLKTSNMDKKSPVSMIAKLEHLLWAVSFVWVFYKLYTCGLNYIEWGIILWMGIYLVNSTKETIHDTSDQSSADEHNDIYDNDKKPIVPTLSRYRIFGASNSSFRDNADDGLVCGILLLPMVAASKLMDLMKKNADQGYIVYVQARLELLLLMSAITLILVFVNEYLHPLKKLIRKRGLFVSSIVVSALFTALVTRILPLTDVLSQLSIMMTVLTVTLFQWFLYICVVTLKKCFTLGEMTIVSQSTAILFYGTLEFIYIAFFPENKPGYLNEDESSTSPISVLIHAVIVGIIIIGVMTYPLLRASRTIAQQPYWRTVDRPLSAFRNKKLMAAIGFYVLTVFIVTFMIAPFCKLIIGENPLIWTLDFLYMSPSRVFLCLYWLLMVITTVTIWAIMLDFTSMLEQQNGYNTEKKVLTSSLNKKRKLFHVLAVLLFVPGVIFEPEFLQLAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5P7</accession>
    <name>A0A367J5P7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002144">
        <property type="protein sequence ID" value="RCH85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5P7"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="15208" checksum="19C851B00647C0E9" modified="2018-11-07" version="1">MSTFRTFSGKFLSKLENAKFVEADVKPQLVYNEAKSKSFWRPPRLSRRIQADLRKACIQEGIEPTSIGLLPETAPKSLRYKPNKLEKHERTRAERQATIQRNMEKMPQTIQAWKEEKLKELAKQKSSMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5S6</accession>
    <name>A0A367J5S6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_003876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01002136">
        <property type="protein sequence ID" value="RCH85288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5S6"/>
    <dbReference type="STRING" id="86630.A0A367J5S6"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="32504" checksum="90982E056BD45BEE" modified="2018-11-07" version="1">MVKKQKKKTPITQISTAKTKFKRSHAETARLIRRFHVLNKELAKCRANPETLKDREAEILKEMESLGGLDWYQKASQLGQSKARGGDSSKWLIQTLKSHCKDALDKTTKPLKVLDVGAVAPDNYKAYSSWITATPIDLNPQHPNIQKQDFLRMQPPALANRFDIVCLSLVINFVGDPKDRGQMLIHTRDFFMPVTTTDRLHYLFLVVPLPCVTNSRYMTHEHLLEMMASIGYTNCIHHHFSNKLAYYLFELVRKPNTKNIIWKKKIIPGKEGGARNNFCIVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5Z6</accession>
    <name>A0A367J5Z6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome b5 type B (Outer mitochondrial membrane)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CYB5B</name>
        <name evidence="16" type="ORF">CU097_002254</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Microsome membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002115">
        <property type="protein sequence ID" value="RCH85372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5Z6"/>
    <dbReference type="STRING" id="86630.A0A367J5Z6"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH85372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="131" mass="14573" checksum="3C63471A3F26BFEB" modified="2018-11-07" version="1">MSTKVISLNEVAQHKSKNDLWLVIHNKVYDITSFVVEHPGGEEVLIDEAGKDATEAFEDIGHSDEAREMLQKYQIGVLDEASQKKEYNVNVVRAGELPKEQKSGSSWRIILPALAILGAVVYKFVVAPKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6K9</accession>
    <name>A0A367J6K9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002071">
        <property type="protein sequence ID" value="RCH85546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6K9"/>
    <dbReference type="OrthoDB" id="426133at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="200" mass="21721" checksum="6200CD3DE28F56E3" modified="2018-11-07" version="1">MDVGDETRIGLPGTVSADSSTTFTLWGSGADIDDTSDAFRFMYQSFSGSGTLESTIRSHLTFAKCAKAGIMIREHLASGSPLIMLGISPADGVFVQVRYRNFGPTKIIKTMKATPPYRLRLTRQSEDLFEAHIQHIDLLGAKTEWEPFASIAITMSKDVYAGLAVTSCDTTVVSVAKFTDVTLYHSSSLTSIPKLVNQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J922</accession>
    <name>A0A367J922_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001877">
        <property type="protein sequence ID" value="RCH86395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J922"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="69" mass="7549" checksum="2D257B0A9008D9BC" modified="2018-11-07" version="1" fragment="single">MHNSLVGNVPIHDSDTDTSVSTTKDIYDEVLDSSAQLSSDMVGHLGIIDVSSSMLRNELDEEELNEITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAD0</accession>
    <name>A0A367JAD0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase 20.1kD subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001794">
        <property type="protein sequence ID" value="RCH86789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAD0"/>
    <dbReference type="STRING" id="86630.A0A367JAD0"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18227" checksum="07946FA99B0CA6C7" modified="2018-11-07" version="1">MSLRAATQRAFNMRALVSTKRQPIMMTSVRPQSTLNTGELVEDPQIGDYPNLPRYSAQARGPHGWWDPQDKRNFGETLHEEDEIMGVWAPDLHEYSPRKALAQLAFFFGVVGAVAGLVYKTYPESPAAKRTYPYDGLKEEFGAREGDIRPRGARVGNAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB79</accession>
    <name>A0A367JB79_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001726">
        <property type="protein sequence ID" value="RCH87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB79"/>
    <dbReference type="STRING" id="86630.A0A367JB79"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="548" mass="60485" checksum="9CF52CB13F459986" modified="2018-11-07" version="1">MKTFTVEEVAKHNKADDIWVIIDGKVFDLTKFINDHPGGKKVLLKKAGKDASKEFKTFHNEAIMQRLGLPMQIGVIGTAETAKPEPTAPAAVEPQPAPVTTNVTKATDIRQLVSNDQARFGEGIPYGDPTWYQDWNSPYYKDSHIKLRKEIRAFVDKEVTPYCHEWSEAKAVPHAVVKRAAELGILNIASGASKKPENAKYMKYPLPAGLKIEEFDIFHEFVCIDEIARCGSGGFIWALMGGLGIGLPPVLNFGSEELKAKVVPGCLSGEKFIALAVTEPSAGSDVANLKTTAKDMGDYYLLNGEKKWITQGGYADYYTVACRTGGPGMGGVSLLLVERTMPGVNARFMDCQGMWGSGTSYITFEDVKVPKSHIIGKVNHGFRYIMHNFNHERLGIVMQANRLARVCIEEALKYSLKRKTFGQRLIEHAVIRNKLGHMIRQCEATHAWLESVLYQVQTLPENVTPNLLAGPIALLKAQSTQTFEFCAREASQIFGGLAYTRGGQGEKIERLYREVRAYAIPGGSEEIMLDLGVRQAISKAMAASKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBF3</accession>
    <name>A0A367JBF3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_007023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001704">
        <property type="protein sequence ID" value="RCH87215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBF3"/>
    <dbReference type="STRING" id="86630.A0A367JBF3"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH87215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="726" mass="81898" checksum="874ECE4362BEF593" modified="2018-11-07" version="1">MTENTKLVDTEDTTTDIATTTPIPTTTTSTEALTTTTTTTAALDESIVHSEPNILEWDSDDTKKEPHPLSIQTLDQYESDPWAQPEDNENDLLTEHDTLVEEQQQKKLEAPAAITTTSVDTTPPVAGTITSSTIAELTTATAVPGKSQDTSASFQNVQDKDTIDDLKVSGQLPKWLVGEYFTVGPGTFDIKYSRKVEIDGEIQLVSAFYTFGHWFDAYSINLGISIVGTDCLYRLPLVNRFDLNGQRNTITYRNRLTSRRLIEKIRDHHGYSPLHPAGLFMSNTNQTVLSKILKTAAKPNKPDAEPCSARILTKIPGLDGRLFCQNYANHIQELDPFDLKPIQLLTWNEINPAFKGTSSCPNGQYDSRTGEYINFTMEVGYQSVKYHFFSISDQNPKGSLITSLTAPMAYVNSFLITPKYIIFVLHPMLATSGGVKYNWCESIMDSFSFKPSEPTLFYVISRERREVMTVYRSDPCFVMNLINAYEVNDTIFLDMICYKDDTIVRQLTTQYLREPHTMKPSRLLGSEVRRYRLPHLEDEHVAYLSKRPAKSRFSLPLFKAFKNDTTQMKYSENATNRWYSWMPIATYEQRIQPSIELPQINPNFKMYKHSIMYGLGFSASNSLKDGAIWDSIVKTNLETKSIMTSWHQEGCYPSEPVFIPRPSIGPEDQVGEDEGVLLSVVMNAATSSSFLLVLDATSLQVLATADLERLVPISFAHGSYRLLETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCX5</accession>
    <name>A0A367JCX5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001595">
        <property type="protein sequence ID" value="RCH87766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCX5"/>
    <dbReference type="STRING" id="86630.A0A367JCX5"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="210" mass="23738" checksum="EAE6F3C21196A841" modified="2018-11-07" version="1" fragment="single">MNIDDIFKIPAIPAGRNKRKMPETPSDDEEGGRFFGGGLTSEQHDILDLVDQYDAEEAVTLDASTVKKMILKFEKAINKNQEMRVRYADQPEKFMESEADLDEEIKNLLALTEAPELYTELIQLGTVTSLLSLLSHDNTDIAIDTIDVINELIDEDVGTTEDQLERSEQVQNAIKALVEAMLENELLQLLVQNLNRLDEKEEADRQGVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD47</accession>
    <name>A0A367JD47_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001571">
        <property type="protein sequence ID" value="RCH87892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD47"/>
    <dbReference type="STRING" id="86630.A0A367JD47"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="17850" checksum="B4902F0FE75FF8F9" modified="2018-11-07" version="1">MNAVSKRLLKELREIDKEAASHPQIIELSPISDDDLLHWKAIIAGLPDTPYEGGQFELSIKIPSNYPIHPPNIRFVTTICHPNIHFKTGEICLDILKTDWSPAWTLRSTVLAITLLLTNPEPSSPLNCDAANLLRCNDKLGYESLIRMYTQLYATKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE09</accession>
    <name>A0A367JE09_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MABP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001514">
        <property type="protein sequence ID" value="RCH88192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE09"/>
    <dbReference type="STRING" id="86630.A0A367JE09"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925266" description="MABP domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="MABP" evidence="2">
        <location>
            <begin position="120"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="638" mass="72141" checksum="EB744CBE96CAD26C" modified="2018-11-07" version="1">MVTILFVLLCISIVHAYITDIKLVSCDSNHACPNYAGYKRISTDLNLGVRGAKSVFMHLKQDPREDPITDIQIVRNTNTTVISDIAKWTRLDVDLNEMEDQEQGRSPLWLYYTKDTSISKNPISSIIVKEGSGPSAAPEYTRIPVDLNDGMDGYHLFMYYSQDGPKDPITAITAKQCFTSNCYMDVGNPFRISGWERVEKDLNKGVVVGMSVYLFYKREKAKEPVTDIVVLLNDQSTPEGYTKVDVNLNSVTLRGDDIYLWYKTSNDIKNAIQDLAIQFGPRPVTPFGWEQIPVNLNSANNGKDGFGEPTYLFIKKGYQELPTVRRLEFDQEGEFKILQLADLHFTNEKGVCRDVPSKFNCKGDDTTIEYIGKLLDRERPNLVVFSGDNINAAGVSDARAAVFKFTSLVVQKKIPWAAVFGEHDDKNELSREELIEVMRRIPYSLIEQGPAELPGVGNYIQNIYTNGTRAATHDFTLYFLDSPLQTMGDIQVNAIQKEQLEWVVQSDLEFQKQNSNPNAAIFFYAPVWEYNHEYPRLGDARESVSTPKNELSTLDYFKQAKTIKIASCGRDHVNDFCLEKEGIQLCYAGGAGVGGYGAAHMGWPRRSRIIKLSQHGQVLTTWKRLDDEKLTMIDFQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE57</accession>
    <name>A0A367JE57_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001504">
        <property type="protein sequence ID" value="RCH88242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE57"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="13817" checksum="0630FC5C11773D23" modified="2018-11-07" version="1" fragment="single">EHVQREDIIPQSIGQLTPIQIPDTDFSIESPSSLEQLEFSITSDTSEDVRDMEVDMEHTLYTQETEQSHCKHLRNEPLPSLINRLNSFGNDDFYNTLLNDFSIPSSQIIASEQNTTKSFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEF2</accession>
    <name>A0A367JEF2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001528">
        <property type="protein sequence ID" value="RCH88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEF2"/>
    <dbReference type="OrthoDB" id="2256515at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="102" mass="12329" checksum="0A1B48E9D6A1154C" modified="2018-11-07" version="1">MQPKEHKHHKSMPSLSSSISSNEISIQSSPRTSMSCNRMSDQVRIKRWDDSPFEMELAEDDLIKPNTSSHKFSETLRDKFRHIRGEEYRRHKFFKKLYHWFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEP3</accession>
    <name>A0A367JEP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001474">
        <property type="protein sequence ID" value="RCH88394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEP3"/>
    <dbReference type="STRING" id="86630.A0A367JEP3"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="299"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="478" mass="55478" checksum="8F5940E84AB307D8" modified="2018-11-07" version="1">MGKPLTSKGKVMFLATADEQNESQLFQDLCTAAKEGDIEQVENLVKHFNAPINYVDEWQCSPLYWACLCGHYAIVKYLLENGAQCDRNTFQGERCLYGALTSDIRNLLLSYKLTKAVDEDQPYLLYLTQLFESHVYHDLTFEIPMTVGHHEFYVHKFILAARSPYFGKNLLNRWSEQDHVKLQRNLVHPMTFSALLRYIYTGYIDYALDNDILDNMLFAAKHLEFHHLHSLLLEQKSSNDALRSHSKEEITMLRHDFEKFYINMITIAMQAEPQQERTWIMIEPWAGESLQCSPKSIFADIAIKLHNNIIFPCHKAYLCRVEFFNTMLSGPFGEQDAKLVTLVYPSQTNMVLPLIELHDVDADIFGYYVLQFIYTDKCNIPAEDAYDVLLVADMLLIDRLKAMAAIVITNQKEPIIDIYELIQTAIELQVERVEQYCIKYFAHHLDNFIHQPQFLDLIKQSAASIKKREETGKDDVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFY5</accession>
    <name>A0A367JFY5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VPS55</name>
        <name evidence="7" type="ORF">CU097_001534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001430">
        <property type="protein sequence ID" value="RCH88641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFY5"/>
    <dbReference type="STRING" id="86630.A0A367JFY5"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="9765" checksum="8160A12C2F1C464E" modified="2018-11-07" version="1" fragment="single">ATYILAPLPNAICGKCSGEDDLTTAYNSGMIDAGHFITGMFIVSGFCLPLVLAHAEVITVPAMIMSIAGGILVYGTIITYTHFFSNQGQEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGZ7</accession>
    <name>A0A367JGZ7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_002895</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001339">
        <property type="protein sequence ID" value="RCH89155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JGZ7"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016743413" description="SSD domain-containing protein" evidence="16">
        <location>
            <begin position="21"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1130"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1172"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1206"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="590"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH89155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1291" mass="145026" checksum="82C6FA4881406ED5" modified="2018-11-07" version="1">MRIPLLLYCLISWLILEITCEPITKIHKEGYCSMRGQCGSFLPVPCAKNIPAVEPESDMFRQSLIDTCGADFATGPVCCDESQLESLISQVKQAERIIASCPACWKNFLQFWCSFTCSPDQSTFVNITSLDDHQGVTGADYWVGDHFGSQFFDSCKDIQFGSSNSFAMDLIGGGAKNWHEMVTFMGMKRPFMGSPFQIDFPPMEGRAPSDGLMRYDQDGKLCNDTDPAYRCACVDCQATCPVLPPTPEEQPECHVGLIRCWSFAMLMTYVIVLLLGLTLVLARNKTIGQWCQRFFGINIDQLEARGLYERLALADDDDDEDDQDLLDPDYTPRRYWLNSRVQNWFYYQGLFCARHPWSVILISLVFVFLCSLGWSRLAIEQDPVNLWVSPTSTALAQKNYFDKHFTPFYRTTQIFFVSESDEPIASAERIENIFKLEQEIKSIKSRTYGSTLSDVCFHPTGDVCIVQSVTGYWQGDLDNFDPENWKSHLDACASQPSDCLPEFLQPLKPQMILGGYEDEKYTTAKALILTYVLKNSMNETDVARAEDWEKTLLDTILSHINERPEWDGVRITYSTESSLETELNKSSNTDAKTILISYIVMFIYASVALGRLSSFNIRRWAVDSKFSLGVCGILIVIFSVSTAVGLFSLTGKKITLIIAEVIPFLVLAVGVDNIFILCHEYQRRVELGQDESIEERTAKTLGKMGPSILLSSLSETIAFGLGTMVTMPAVSSFAMMAAIAVFIDFLLQVTCFVSCLALDARRVKDRRADCVPCVTVKAPEVIEKEGFLESMIKLYYVPVILHHKIRYFIAFAFLGLFMLGLSLAPQLPLGLDQRIALPSDSYLVQYFDDMSQYFNVGPPVYFVVKNANLTDRQEQQKVCGRFPACEERSLANILELERKRANVSFIGEPTSVWLDDFMLWLNPNFECCRLKKQPRRLSNLDRAYYESKPELCKPTDPQRRCVDCIPNYDSTMKAIPQGQAFLDMYDYWINMTPDQDCPLAGKAAYGDAVAVDREQMTVVASHFRTFHTPLRTQDEFISAYASARRIASDLSQELNLDIFPYSVFYIFFEQYTYIVSMAFEILGLAILSIFIVTSSLLGSLRCGLIVMGVVIMILVDVVGVMTLWGVSLNAVSLVNLVICIGISVEFCCHIARGFMVASGNLEDRAGKSMVDVGSSVFSGITLTKFAGIVVLAFTRSKIFQVYYFRMYIAIVLLGALHGLVLLPVLLSMFGGEGMALTADFDEDGFAWHTGQGRQGLLIDDANNESSDQVLITDMPRENGYEAIPGMSTERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI32</accession>
    <name>A0A367JI32_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001270">
        <property type="protein sequence ID" value="RCH89545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI32"/>
    <dbReference type="OrthoDB" id="2227940at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="476" mass="54379" checksum="7DE2A06EE259AAD5" modified="2018-11-07" version="1">MSSFDTAVVLLGPIFLKQGSQFEGDYTLSNLIFFNEQSDQTDMIDVIFNLEVIISTSAINFFMIERKSWQVATTDTDGRLNRFLNEVFGVDDECPEESAKAAIFKVEMNDVHSNNHKYFMVYSEIKDECSYLYAVPITDTKYMRSTYGLTGDLIYKELSYTIDKQMNNQSQKGAQKVLQKERRQEKIINEIIQLDDGSISDDENDLATKLDVLNNLNMEEVEVGGLEITRVLSPAFEEHIKDDKVSSANTNLNDDWNMTKLIPKDLLSREDTTTSQICQQEETDGGGGGSDGDRPIQKPLKSKRERLLDHLFNEDGEDDPEFDFSVQTDWTTQYSKSRGSSRRGSEDFEGPMLTDLLNMKRSREEVEQRGLPSKKQKINTASELQPRPLAATSSSTPMPTPKPSTPKPTEDKRYKIKKMVKDALGANFSVERYTLIYQSIKHHFQDKLEMADHVRLRSIIQSHVAFHEYIDTLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI72</accession>
    <name>A0A367JI72_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001266">
        <property type="protein sequence ID" value="RCH89569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI72"/>
    <dbReference type="STRING" id="86630.A0A367JI72"/>
    <dbReference type="OrthoDB" id="2261218at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="306"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="469" mass="53454" checksum="00B9362EE27082DD" modified="2018-11-07" version="1">MSSFPVLRNPLLPSPPRKKKSSKLSRTEFFSSLQLSAAASLKPSISTDSFRNFVNHTIHHISGANVRMNKRIMPSGMPKSATMDMNHDRYPSMEPLVHYNGPQHTLEELPAEKLNWIKEDQLSNGMKNPLSHYNRSIVLRKPLKRSKTYHQLSLACALQKSEIKPKAMFYLRILQVTATDTSKVRSFKCTVQVNDDICAGSFVTGEKSGKNGTIVHFDETFLFDIEEPTTATISVYAKSRSLFGGKQNETCLGRETIPIHLQLKQKSAERFVLNSDPNSGQSNDFQLLVIQGVYVSRRSQTLLNNTVLFEDYITVHTHSGQSQRWERFWGVLHATQLELYDFEYKKSRSPLYVIPLDQFISVSSIEEDEEDHWADIGSRGLVLEFTSKALDKEERGFAFSEQRDQGCRMYLLPESTASAREWKDKFNYAASIFDELGGDLSDYDEDSSVYSYEYSDSSSRLTVPSKLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIH0</accession>
    <name>A0A367JIH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MND1</name>
        <name evidence="9" type="ORF">CU097_009522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001236">
        <property type="protein sequence ID" value="RCH89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIH0"/>
    <dbReference type="STRING" id="86630.A0A367JIH0"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="145"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="23008" checksum="B870553463B867DC" modified="2018-11-07" version="1">MGEFYQLKDIEKIGPKKGVGMLYTENEFMLRLIVHIVAQSVKDVLMSLVDDGLVTMDKIGTSNYFWSYPSAALQLGKNKLKDLQASLEKEKAKQQRLQEEIGEAKETREDTDERAELLKELAELKAKNKELMNELQKYKENDPVLFEKKEKAAAIAKEAANRWTESIWEIESYCVKKFNMDRTAFEQNFGIPEDFDVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ77</accession>
    <name>A0A367JJ77_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001194">
        <property type="protein sequence ID" value="RCH89993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ77"/>
    <dbReference type="OrthoDB" id="2225407at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="34982" checksum="4D1888B532FD1129" modified="2018-11-07" version="1">MVDPTTNTFPVLPEELRKKLRTAHATYNVDFLDQAKQLLVRRQRFEDRRRKRLETRFAKGSDHIISKTPVLISKKRRMRDPIQLVHRKRLPPQPRCSECNVRLDGNLETSPLSAAVLEPKSTVVSAPVCVGCDRLYTLASNEEEKQNITRWIVTGQLPKSIDVKLLKPIDQFMSVEAAAEVLLTQAESFYDIAAGPLPVFFHQDELRQLYRENGCKDSILKHEVYWPAALDGAATYAHIEFDNVQPLWTMTNDDDFYSIKNMQIISKALKTVKKNSRLDELEQWLNGFLHTKRQMQMLREYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLF1</accession>
    <name>A0A367JLF1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001069">
        <property type="protein sequence ID" value="RCH90780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLF1"/>
    <dbReference type="STRING" id="86630.A0A367JLF1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="324" mass="37004" checksum="12D66E325DB85477" modified="2018-11-07" version="1">MGNCFPVAHRAQPIGDRNIISQEDTFCNTMTAYKENTTIVNSTTNTNREFHKEESSTYWLPKDEEEQMRLTGQHYAFKSLFEGNVLPSVTDTLDFQKGINILDVGCGSGVWIMDMVQEYPNCTYHGCDIVNILYKNVDVKQFTFSKGNVIKGLPYEDNTFDFVHMRFFVLALREDEWPMAIKELIRVTKPGGMVQISEIGFKASLPKDTTNIFYMVTSAFRDTCKARGQNVYIGAELEYMLSKFDSINITQSECRLCDTSSGTNTAKLFIWDALEVIKSVQKIIGPLLGINTKEELDIFLKKYRHDLETKESVYRLDSVAVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLN0</accession>
    <name>A0A367JLN0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001065">
        <property type="protein sequence ID" value="RCH90805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLN0"/>
    <dbReference type="OrthoDB" id="2280028at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="95" mass="10640" checksum="823A2A4C58D4115A" modified="2018-11-07" version="1">MIATISNTCTSVNNNHSNTNVRRNSFSEFVKSLLLLVSPSNNHDNSNSKQEDIEKRSPSLFEDMYVSFPAFEEQEESTGCHPQPSLIVGTSRIMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLW0</accession>
    <name>A0A367JLW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_002459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001049">
        <property type="protein sequence ID" value="RCH90908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLW0"/>
    <dbReference type="STRING" id="86630.A0A367JLW0"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="240" mass="27669" checksum="E881633183B11034" modified="2018-11-07" version="1">MPKAEFGTPKYLSNKMKSKGLQKLKFYCQACEKQCRDENGFKCHMMSESHQRQMLVVAQNPGKFISSYSEEFKQNFIRLLSRSHGTKRVLANRVYMDYIAQRDHIHMNATKWNTLTEFCKEMGRAGIFRVDETERGVHIAWVDNSPKTLAKQAAIQKMERAAKDDEEREKELLKEQVEKASKLAEEKGLDREAKPTELKREGEQPIKLNLFMKPAAPATSPLTSSSGSKMMLGFKRRKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM85</accession>
    <name>A0A367JM85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YOS9_1</name>
        <name evidence="11" type="ORF">CU097_007533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001030">
        <property type="protein sequence ID" value="RCH91037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM85"/>
    <dbReference type="STRING" id="86630.A0A367JM85"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016901472" description="Protein OS-9 homolog" evidence="9">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="113"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH91037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="403" mass="47354" checksum="969AEABDE5EE2B7E" modified="2018-11-07" version="1">MLMKSILIAVTVLIQSTLASYFVSDDVLNLPRYKVSLLTTEKIPQSQLHDAAFNDQTMLMRDSYGQPFLCNIPQVDRDEAEHQEQMETETKDTHEDEQKLIERGLELLQPLENSCLQFYTHQYWAYEYCHKQYVRQFHVESVYDGRVERKKETASHYLGKYPGVTIDQNPIIENALLPTIRRDKTAKRPATTLKQVGNQRYLLQQWGDGSTCDFTKKPRTVEVQYQCEYQGHDRISYMEEISTCHYLIVISTPRLCEEMKLSRIPKPRIHTISCTPIVSDKLIEAEREQEEQKQEQQPLIEEQKEEEKSMDDETKERVISKDPILKLLNDLNEQIDLLKSQVNGYSSSDDDINIMFIDEDGNYISSNSELKKLLKLEKTFKKKEEKEQKEQPRLKLIDIFQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNC8</accession>
    <name>A0A367JNC8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_009467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000969">
        <property type="protein sequence ID" value="RCH91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNC8"/>
    <dbReference type="STRING" id="86630.A0A367JNC8"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="36"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="438" mass="47645" checksum="B48F6856C8B66715" modified="2018-11-07" version="1">MSLDIEQAPNYGTIPADEIIIEDLDLLQSSKPGYGTRSIFEVSLNIVNATVGSGVIGLPFALFLSGFTLGITISIFVGLLTFAAVYSLILTGQKSQIFNFASLAEVAMGRFGYHMLNFMLFIQSAGSVISYFILVADTIPILLGLYFPRYPLLADRTIVTTVVSIFVIFPLNLFRSIGALAKWSAFAVLLLPIMILSVLIRAPAYAPDHEAPIFRLGKDPIAAAGIMSFAFVCSQVAFSNYLSQKNQSTSAWKLSSIVSTLMSWTISITFAAIGYLSFGQDVSSNIFSNFPADDNIINIGRLALGLSMVLTVPMAFYPARDAVQKTIGFETVDRQPTALQHYGITVILFAFFLVCGVQIRSLGKVYSLVGGIASSFLAYIIPGFAYIAVFHPGWLRRSVPLVDNKTPLVSSSWWLDIISVILVVFGAIVMLFTIKSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNN0</accession>
    <name>A0A367JNN0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000957">
        <property type="protein sequence ID" value="RCH91528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNN0"/>
    <dbReference type="OrthoDB" id="2234393at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="91" mass="10314" checksum="115DA2D3CA8A0EAD" modified="2018-11-07" version="1">MTHTYDLNGVTMQGTISDASFKVDLRVLNDKLKQRYNTEYDRTIMEAAENGPGNTKFISNRCKLSIKNKVVIDKYLMDGVNIISIDPLQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPD2</accession>
    <name>A0A367JPD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000920">
        <property type="protein sequence ID" value="RCH91788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPD2"/>
    <dbReference type="STRING" id="86630.A0A367JPD2"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="305"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="490"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="82991" checksum="6D98CD10E30F34E8" modified="2018-11-07" version="1">MPIRHFDIFTAERRLIQTSAVSQLKDTRIGIEGNDWLRKIVPKEPTVTAMGGLPLRLRESIEKELKQFKSHGITPIFVFPGLSILRKDKPFSKEDTRPSHRAAGWEFYEKGKTDLAMSNWASSGGIHPADLLNCVFHILHENDVEFVRAPYSAWAQLAYMYTHPKQLVNAVYGGSELLMWDIDKMITSIDFEKGNYHWINKKTVLQDLHVSDEQFLDICILAGFEYCPSFPPLNTSVVSFTFKGVHDLIKQHKTGFNAVQAYSDNPIIAKTHYVDIFCRTRCAVKYHLIITDEGEIKPLNIEHAPNDIHEFIGYRLPDELYYYLMRGLIGPQSVNSLVSGVLIENAPLDNGESTEYHNFLHQLLNIRTQTLSLLTQPLHQFYKTRKIATHFWFEPTVEQIMHHQPNDSHGSAHVDATPLNTVYEKTNSWNVTRDFIDAELRSQKVNTVTLKFCISTLENASVATKTITKPHPDQPLEDKNEIVANVLWKTLEIRDFVTSSKHVHTPWGKALHVSLKGDDVPRPMQEALLTALELIRFEVLTNKTFSKTYTRPLGNELEQKNIILLSRALSLLPIKLKNMQWSGPLNRDLLVFNSFVKALNRSYRNLCEMLTLSFFLNGLVVKDREDYFEINDSLPYMADVNVALGLVCKHYLERIVEGQSAIEALASTEKAFPTCVSVKEDLETGFQFWTRLLEAVGVLFKTNTISADTFNMFSNANEWLQNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPX8</accession>
    <name>A0A367JPX8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000890">
        <property type="protein sequence ID" value="RCH92003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPX8"/>
    <dbReference type="STRING" id="86630.A0A367JPX8"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="33560" checksum="3C79031347FBE016" modified="2018-11-07" version="1">MTSFANLLRNSRLATFNRSIDQVYTAPSHCKQIGDWGLKRSLPTVIRTPYLTVQQLDTAEHQTPWRSGNSQVLFIKRWKENFPNSKKPAPRSDQDKYNIVKMTPAEFKRFLQQCAKRAPEFRQLLEQKKVVPEQVFDYLQVAFKDSPGDAVVGPLYSDYQQAEPVIVQGRILNAAKRNGHVVGVGGITALLPKRHTVYMRQLGDRRVRTFYVEEASIDEEGRPRVILSAAPKDAHAHAITIEEVDETAKEMFLTSRPPAQKIMSDDHIEANPNHDLIMRRIINLMGNVENDNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR41</accession>
    <name>A0A367JR41_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_012636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000831">
        <property type="protein sequence ID" value="RCH92420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR41"/>
    <dbReference type="STRING" id="86630.A0A367JR41"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="252"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="537"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="764" mass="85421" checksum="77E6F8EC6D981E45" modified="2018-11-07" version="1" fragment="single">MPDYTNNVYSQLAKPRTTIHVARQGFDGDIIGYRESIIDDPNLTAINSTSFSRSFGSTKNFVRGSAAQFPFAPGGLEAEVIEEEDEGHVEVNVDADLFDLSGAGNIAPGLDRGLSFGDEEEQQEKEMEALSKKSTVFSIENMMDPLNNTFDFLDVKVKPVDGHVEEPVPTTKVEEALDVAGPQEVDELFPTSLPPQKELVTKKLTTASEALKRREWAHEINVNEPFENFHDLVPEMAMQFPFELDTFQKQAVYHLEMGDSVFIAAHTSAGKTVVADYAIALATKHMTKAIYTSPIKALSNQKFRDFKHTFGDDVGILTGDVQIKPEASCLVMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIMLPAHVNIILLSATVPNTREFAGWVGRTKKKDIYVISTLKRPVPLEHYLYANRDIYKIVAANENKISTIGYKKAQDAMTKRKEQIEKSSGNSNTRGGRGGRGGAVSRGGGKPIGRSYHAAMQTDRNLFVHLIGMLKTKSLLPVVIFTFSKKRCEEYASGLSKTDLCSNLEKSEIHVFIERSLVRLRGSDKHLPQILRMRELMSRGIAVHHGGLLPIMKEIVEILFARGLIKVLFATETFAMGVNMPARCVVFSSIRKHDGRNFRDLLPGEYTQMSGRAGRRGLDSTGVVIIATGGDEPPEASTLSTMILGKPTKLESQFRLTYNMILNLLRVEALKVEEMIKRSFSENSTQKLLPDTKRLVDENEQKKSALRQLDCAICEPDIERFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRB6</accession>
    <name>A0A367JRB6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_008485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000820">
        <property type="protein sequence ID" value="RCH92494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRB6"/>
    <dbReference type="STRING" id="86630.A0A367JRB6"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="172"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="524" mass="60040" checksum="03A9D7EA6E4E7C97" modified="2018-11-07" version="1">MTITDENANISNKPNSPVSAASILRPRNNLNSPIVARNINKRKQTDDSTNLPPAKVLRGISSNNIGSTITTPLSDTPKLANATLGISDFAQSTDKEYKNENKENSESVVEDKTEEKVTKEKSQKKEDEQETESKDDTKTKEEIEMDKKAKLELEKEEMKNLMDTLPYLREYYELEEKIGRGTFSTVYKALDIRREMYKNDDWLPTMLIKPYTGQDKAEHMNSIKTLNEFVALKRIYSTSSPQRIVNEIRILQELKGAECVSPIVTAFRDGEETFIVMPYIQHDEFKDIFNVMGLHDIKCYIKSLFTALSHLHKLKIVHKDVKPNNFLYNVKKKVGFLIDFGLAQREDETKQYEESQVMGDLSKIELVKGYDTNDTRKRIKANRAGTRGYRAPEVLLRVIHQTTAVDIWSAGTIFLSILTGVFPFFIGYDEADSLVEIASVFGLNDLQKVALKYNRIIHTNICGLPKQRVSLKKLCAYYNSEKLREWPEKDIRDAIDLLEKCLQLDGNTRITAKEALKHPFLQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSS0</accession>
    <name>A0A367JSS0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000755">
        <property type="protein sequence ID" value="RCH92990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSS0"/>
    <dbReference type="STRING" id="86630.A0A367JSS0"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="2">
        <location>
            <begin position="191"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="354"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="63998" checksum="882AD6EEDD72005D" modified="2018-11-07" version="1">MPLSFGAGSHEIVEATKRHSRSLDLEQTNARHVRLLHQRSASESDGLVLENDNTIEKQVPSKVFSLYKKLSTPSRYRSGKTTGSFLPEIKTTDRFKKSRASFSSALSTFLPNNTKHNQTETTLSTYRQTEYDKTNPTYLLAQTGESRRSLPSTLQNDINQFAIDGYAKKYFATHKRGLFRRTVPINEMLQWTKDSIRQPLLLSNKNLCKDALKCFRIIQILMNDRPRPRNYNAMEHFQSLLDCGISKGQMRDEIYVQICRQLNKNPRSESIRKGWEILCVVCITFPPSKNLESYLYDFVKQHHSIKENQVDVYSQYVTVKLERICSRGARGKVLSIAEIERAMEAPFKPSIFGEPLETVMNLEKKEGLKIPRIILFLTNAVHELNGKKTEGIFRVPGDADMVTDLRVRIENGNYDSTGIEDPNVPASLLKYWLRDLAEPLIPERLYQRCIENANDGEKAVDIINSLPDCNRRIVLYIISFLQDFTEPEVIQHTLMNVYNLAMVFAPNFLRCPSTHLPTIFANSKHEQTFLKTLISVLQVDREACAHQEGEIIGRVNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT59</accession>
    <name>A0A367JT59_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Complexed with cef1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000735">
        <property type="protein sequence ID" value="RCH93144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT59"/>
    <dbReference type="STRING" id="86630.A0A367JT59"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27077" checksum="EE3289D9B4AB0296" modified="2018-11-07" version="1">MTTAARPTFDPARGNDNKAPSFQYGARDLASHTKLKFRQPGQGTADEIGSREELLAELREAERKYFEEKEGKASSNRLIKQDGENNINEEKQKLLAEAERLAKLDKEDTDEESENESSSDDDDDDDDDDDDNAAELLATLQRIRKERAEEKERQEREAREEEEARRQEEALQGNPLLHIGEQKRDFSVKRRWDDDVIFKNQARGVDDKPKKRFINDMLRSDFHKKFLHKYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTL6</accession>
    <name>A0A367JTL6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ERAD-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000714">
        <property type="protein sequence ID" value="RCH93304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTL6"/>
    <dbReference type="STRING" id="86630.A0A367JTL6"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="72182" checksum="73456BB66CC23944" modified="2018-11-07" version="1">MSPIFSFSSSFTIIYRSKEIILSKIKHSIEDTSMPSSHSSSSSCDGQHYFQKGNYYLFGRKGYPVNQEKAIHYYTLAATEYNHVQAEGIIGFCYEFGLGLPKDFVEAERRYLAAASKGDGLSMARLAFLRKYGRPNVRINRVEAEEWAEKVKQCPNAVDWIVQAATLDADPSAQYALGVCYHDGVGMPKDEKAAFRWYKASAEQGHARGQGILGYCYGEGFGVAKDELEAMRWYLLAAAQGETVAIYNVGYCYEDGIGVEKNVQEAVKWYRLSAEQGNAFAQNSLGYCYEDGIGVEQDFKKATYWYRKSADQGYPWAECNLGYCFQNGIGVDKDDTLGAYWYKKAAVQGHARAQHNLGFCYQNGIGVEKNEEEAVKWYRRSAERGNIFAYHSLGYCYQNGVGVPINEEEAVFWYMLSAKDNHAPAQLSLGYCYRNGIGVPKNEREAIKWFRKSAEQGNALAQNSLGFCYEEGLGVKKDCPRAVYWYHKSARQGNPWAQCNLGFCYANGIGVQQNNEKAVYWYKLAAAQNHARALDKLGLHLQSGLGVEKNLESAFKSFLKSAEQDHVAAQYHLANCYEKGLGCEVDLAKATAWFEKAAIAGCRSSHERLRRLLVRACLVSPGSIPLTSDDDLTCTEFICGYSAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU11</accession>
    <name>A0A367JU11_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Opi1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000698">
        <property type="protein sequence ID" value="RCH93430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU11"/>
    <dbReference type="STRING" id="86630.A0A367JU11"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39328" checksum="147CB7AF70AF92E7" modified="2018-11-07" version="1">MSITQLCNNDENNKNQTEKKIPLPAMEPIPSQPHFIRRLPLIDSALKAYENSIVKYGADMIDTYAVGPIYDKLGYGHKSQEDEDTIAATTALARTSLQDTEVTHRHKRIEDTREDRKFYIYIYIYIYKKKLMFMIINTGKKQRPSTSPHPYSVQRRPRWQQIVLHAGSAAGTTAAVISEESMKCLKYCLSWLQYAVQHIEQQMTLLRQFLVSLATNQQQQQQQQKQVTQDASDTTLNNIKKEIVDTLRKVVEVVSRYAGKGLPEQAKLTVRSFILELPSRWAMVNQQALDEVDTPLHVTSIKLLDFSGESIRMLKSVSLVFSDTVERAELWLKRLKAVGGTTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUI5</accession>
    <name>A0A367JUI5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000680">
        <property type="protein sequence ID" value="RCH93576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUI5"/>
    <dbReference type="OrthoDB" id="2286987at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="359" mass="41102" checksum="65C4953B62C43080" modified="2018-11-07" version="1">MMEEWMTVETEYKKLQSDWTSLNTVSLNSPNLLFVLFSNYLSQIWTDAQSMLQCAQFWQSIIVQGHDLTHLVQTMNSLGLHLMKQSLQTRQEMLNIVSRDDNDTFYSTISPSLYQVMPVESMVFTPTKVKLMRSPSAPTPSSSITRRRLLSCCYSKAMPSIADSKWNRCQEHGLLKRSLSFEYYQTAVNGDSSEEEEEEEEDNILHQHDELPTKEEYESDTYLEENRSMLYQPSDLNGDLSACNLSNTATLSSFSTHKVNPVPHSSSQLFENTHSSGDTIAFDNYCCEKVQVGNSNDIQKSSSSTYKAISNSILQPFWSIRLALKKRRSQKVEAKETSLQTRPKKGLGSKFYLKKKYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUJ5</accession>
    <name>A0A367JUJ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000677">
        <property type="protein sequence ID" value="RCH93603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUJ5"/>
    <dbReference type="OrthoDB" id="2285782at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="11261" checksum="C25C5588548BDA33" modified="2018-11-07" version="1">MFNQWPRIQRESDATIALTESTKKYSLKPLVSCLAMPHTPKIQVIDSETIMKGCALGIEFLINNPKYSKTDEMKELKNNQHKQQKNIFLSWTTLVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVC5</accession>
    <name>A0A367JVC5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000648">
        <property type="protein sequence ID" value="RCH93857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVC5"/>
    <dbReference type="STRING" id="86630.A0A367JVC5"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="157"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="418" mass="47127" checksum="04A034F43C292D56" modified="2018-11-07" version="1">MSLRILRNAVFVSLFIMIILHEISCMILPTKTTYVAHSTTLLSEKPTHLFKRDDIETNLELYQNWASICRQYRNGGYSAIIASNTSDNIDINKLWKTITQTVNCGPGGPVTVTTTVSVSPTSAPSNSGSISCQGQCWSDYLWHTYGDGISPAQGFVGTLCIVVGFYFFILGFRFFRPTMALVGFIFFATMTWIGLVNNEPTGGYPLADLIYICVSAGLGVLGAFLFVYFYPVGIYCLAGLGGFYAAVYIMSWKEDLVIVIKVARVCFIIGCGVLSCILLYFAETYMVFMYTAFIGSYLFFFGLDFFVHTGFINPWLLIFDGNPNHHNTYLMSTSVRVMLALVLFIFLVSIIWQYYWHVIRCPRKFGVVIVEEEVKKEEKKEEKPADPPSEPIVCCPPPYYPPPYYPQPVFTQNIYTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVD2</accession>
    <name>A0A367JVD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_005099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01000652">
        <property type="protein sequence ID" value="RCH93819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVD2"/>
    <dbReference type="STRING" id="86630.A0A367JVD2"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="169"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH93819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="906" mass="101572" checksum="DD0D65B8CDD6F095" modified="2018-11-07" version="1">MSIAMQKHRQKPLSTATVVDRSFKGISLAWLLICASTFLGMYLSFCFHYRLPSPTNQLGFSPETGLSEFSEKNAIETISYLSETIGYRIVGTVEEQQSYDYINNIIQQYQHEAKGIPGSPKFDIWFQQGSSSHRFDIMDKMVLKAYTNVTNIIVRLSCPINPEHPEDRSCEDNAILLNAHFDTTLGSPGATDDGSGIAVMMELIRVLSKRDWSSHKNAVVFLFNGAEESLQDASHAFITMHELRNTIRSVVNIDACGTTGREILFQANSKEMVEAYRQVPYPHGTVMANDVFRTGLILSDTDFRQFVQYGNLTGIDMAIYKNSYLYHTHLDIPRYLEPGAIQHLGENTLAIVNYLAQNASLEDIKPSSEVVFFDFQGLFFFVYTWATAYTLQMSTVVLATAYIGYVTLKTHRSSPYRSISSILISYAKSTTSVFASMISALLLPVTVALLITSDTFNRHMAWFKHEWYGALIFSPTGLVGAYAVQYLFYQLPGPAHFDMEYGTFNSLMLCFAISTFLSTLTGVASSYIFWLYCVVLLVACVLNECLRPAPSKIYLPQVSHVTYSVTSFVLAFLYADYAYALVDLFVPLTGRMGVDTPVDVIVAVIYGMIVFMVSIPSIAHVHRFGKGVIKKMVILLLLFQTAVLTAVYIGGGTFGGWAFPYDELHPKRLFIQQLKNLTSGEITVGVAQADHGPYIQTVIGTLEDRLGVKAETRRAPDHMNDWDSIYPFSAFLGGYRFDVEPYIRSTGNFTEQSLAAALSGPFPEMKVYNDTFDPQTGVRSFSIVCYAPTYTWTVAAFDGHVVDWSIQDEDPLPTSSHYVVRHVSGYGNDGWTIDLSFKVPEEEYEKALENKWKVRFEFTALEKESFAGRGEERLIGNVGIMSVVKEALPIWTSTTWLSSVVKVWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVD9</accession>
    <name>A0A367JVD9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_005892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000642">
        <property type="protein sequence ID" value="RCH93900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVD9"/>
    <dbReference type="STRING" id="86630.A0A367JVD9"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="310" mass="35451" checksum="3128A2C08E7BBA49" modified="2018-11-07" version="1">MTEALVSIPTFSKLSSRVWRVLGLNPGKVTLQGTNTYILGAGAQKLLLDCGQGISEYTPLLENSLKDIQADAYISDIIISHGHFDHWGGLHDILSSSILNPKKQIRVHKFPLPAGKHIDHLKDFPQDISVLPLKDEQTFKVDDVTLKVIYTPGHTSDHCTFWLEEEKSLFTADCVLGQGSTIFEDLHQYLSGLEKLARLQPRRLYPGHGPVIENGTDKINEYIRHRLEREDQIIQLFNQQDGWTPMEIVKVLYKDYPESLHLPAARSVVLHLYKLHKDGKAKTAKHYDFVQENYPHIINSKWYWVNQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWB1</accession>
    <name>A0A367JWB1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1754-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000602">
        <property type="protein sequence ID" value="RCH94220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWB1"/>
    <dbReference type="STRING" id="86630.A0A367JWB1"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12151" checksum="6477E8F36B7DC242" modified="2018-11-07" version="1">MSAYDEVKKGSLKFKGGGSSSVKKKKKKSKSDKEKLERALRESSTEVFQEVEKTEAELKFEEIQRKRQMERVSKAATKSHKDRVSEFNQKLEKLSEHHDIPKVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY87</accession>
    <name>A0A367JY87_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HDA1_1</name>
        <name evidence="13" type="ORF">CU097_003093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000532">
        <property type="protein sequence ID" value="RCH94855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY87"/>
    <dbReference type="STRING" id="86630.A0A367JY87"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="308"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH94855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="642" mass="72204" checksum="AB8DC6ADF4495C92" modified="2018-11-07" version="1">MSPEQSLKRALGSLTDQTSKKPRNYEREDNEAINIEEQTTTDSNRNATIRNGGFSKVRHEEAESRTVVIVSDLEDEDDTESEEGTELERADNQVPENTTTERDESVQPKEDVSEGKGETMYITIDDDSGDEYNDVEHNTNAIDFKVKEEDNNNRVSENTTDASNDRKDKASEEDVIEPTEKNKQDKKSINVPVNDSRETEAEAMEVDEEITPIKPLGQKKKKQDDSEDDFTLPGHNSTYVPPPITRPKRKPAPKPLPVTTVVKKPKRSNSPREKASFEHISKRRLLKTGFVYDTAMSYHATPDPIEIHPEDPRRIFKIYSIMEKHGLLAECKRIKSRKATKKEIIAIHSITHYRKMRATTKFNKRSQYIELEHVYDSVYLNSSSFESALYAAGSLIELLEALVKDEIRNAFAIIRPPGHHAEHDAPMGFCLFNNVAVAVNHCMKKLDVKKTVIVDWDVHFGNGTQSIFSSDPNVLYISLHRYEDKTFYPSSRKGAADYTGHGKGKGTTVNIPWPCSGMTDADYLYAFREIVIPISMEFNPDLLVVSAGFDAAIDDPIGQCKVTPVGYAHMVHMLKSVNNGKMAIALEGGYNLNSTAMSALACMNVLLGDAPPPITSNLAPKKECIETIEQVREIQKEFWTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYJ8</accession>
    <name>A0A367JYJ8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Grainyhead-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GRHL1_5</name>
        <name evidence="3" type="ORF">CU097_010369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000504">
        <property type="protein sequence ID" value="RCH95072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYJ8"/>
    <dbReference type="STRING" id="86630.A0A367JYJ8"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="2">
        <location>
            <begin position="254"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="695" mass="78737" checksum="225F8B7425BBC08F" modified="2018-11-07" version="1">MSFGLSHLRQQGQEDFCYDIMPLDIGLNEIERNTTSSYPSIHPDLPAFHNPTFSDWPVNKSRHSFILESNPPLYPSTPTAYPIYSNANTLTSSTSPYHSSFSEASQSSPTLFWTAPTTNSTLFTTDIASSENTPTSAKISCSSSSEAIFDSAEAEIDERDSDSRNPSFDQQFMNVYRSQPKPTEDAYYNNRISKVHSRFKSANACLSSYGEKPKQEKFQQFLSPPLPPSSLMQSGQPLAESNTLTVGSKRLSKSPFQFHAVLHSPTAMMKKEDQKPITYMNRGQSYLLELSASNQQRGTLTSTISIAFHESSHRRVAASYWRFWMSQQMNPESARAIGLDENQTTGIYNITYPSFDKVTFDWHGRFGAKVYIRFHCLSTDFSRIKGVKGIPLRAVVKTVARYDHLPDNASSYSGSFSKIQPKSNDSTEGRYEYTERCYCQIKLFRDKGAERKNKDDSKQINKQMEKAIALTLGHPEQHPLWPIINQPYKPVTVLNEVPTSPDLELHDDFQQDIASPSVLYPCAIIENTSPEQEEPMPSTTSSSSSSSRKKRKQMDALEKVQETTVGLSSPQFIEPSSHLLKKHRAVADTLNFYVWSKRQFPSSGPNRVTLESLTAEELKLKLATILSLHPSRVSEILWKRKKPEILCEKESEKKNNDMLVLVEDNFVAEHISDEEIICVDWEIKSDSYVRLILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYW5</accession>
    <name>A0A367JYW5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPL3_1</name>
        <name evidence="9" type="ORF">CU097_006559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000496">
        <property type="protein sequence ID" value="RCH95154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYW5"/>
    <dbReference type="STRING" id="86630.A0A367JYW5"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_uL3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH95154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="30420" checksum="41C3F388491DF28E" modified="2018-11-07" version="1">MALRLFAKTAFNTNSKSLTSLRAITAASFHTTSVSCQAAPVEWKIDSVRTGVIARKKGMTALWTESGVRIPVTVLQLEDNVVTDIRTEEKHGYTALQVGCTVKKEKHTTKPLLEHFKKLGVGLRQKLFEFRVTKDALLPIGTELTASHFVEGQFVDVTAPSIGKGFAGVMKRWNFKGLPASHGVSLTHRSAGSTGQRKWPSKVFKGKKMAGRLGGENVTVQNLKVVKVDPALNLVFVKGSVPGFDDQFVKIKDAVKLRGEKLFPKEAIPPPFPTAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ20</accession>
    <name>A0A367JZ20_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Class II myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MYO1</name>
        <name evidence="18" type="ORF">CU097_013132</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000493">
        <property type="protein sequence ID" value="RCH95186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ20"/>
    <dbReference type="STRING" id="86630.A0A367JZ20"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="33"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="17">
        <location>
            <begin position="772"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="1035"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="13">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="960"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1098"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1009"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1098"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1170"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1187"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1199"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH95186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1236" mass="137650" checksum="1E1D85F6EE1F1E0E" modified="2018-11-07" version="1">MAKKLLGKKTGEKIKANRPARADWKEGVKKKQVGVSDMTLLTKITNEAINENLQKRWQNAEIYTYIGHVLISVNPFRDLGIYTDDVLNSYKGKNLLEMPPHVFAIAESAYHHMNSYKENQCIIISGESGAGKTEAAKRIMQYIAAVSGDGHNSSIKEIKEMVLATNPLLESFGCAKTLRNDNSSRHGKYLEIQFNTQGEPVGAIITNYLLEKNRVVGQIENERNFHIFYQLTKAAPSDYQQTFGIQGPESFLYTSKSNCLDVPGIDDVQDFQATLNAMSIIGLQKEEQDGIFKILAIILWLGNVVFVEDDNGNAAISDMDVANFIAYLMEVDSEALAKALTSRVMETQRGGRRGSVYEVPLNIVQATAVRDALSKALYERLFEWIVTRVNVSLQARSAHQYTIGVLDIYGFEIFEENSFEQMCINYVNEKLQQIFIELTLKAEQEEYVREQIQWTPIKFFNNKIVCDLIEEKRPPGIFAALNDACATAHADSGAADNSFVQRLGFLSSNPHFESRGSKFLIRHYAGDVLYNVEGMTDKNKDSLLKDLLNLATGSTDHFISHTLFPERIDPNSKKRPPTAGDKIKLSCNTLVTKLMQCHPSYIRTIKPNDNRSSSEYDDKRVLHQIQYLGLCENIRVRRAGFAYRTTFEKFVERFYLLCPTTGYAGEYIWNRDARSGCLEILKHNNIPAEEWQLGTTKVFIRHPETIFALENLRDKYWHNMATRIQRAWRAYIRYKIECAKKIQRFWRQNKYNIGYLQMREYGHQILSGQKERRRYSLVSMRRFTGDYLDIQSGSGLSTMIRDAIAFKPNEQVVFSMRGNTLVPRAMRSSVPSPRTIVLTNQNLHVIIATKNGKVLSMVDEKVVSLNVINSISVSTLQDDWVILHIDSSPDGDLILQCAFKTELLAHICQQTGGRVKVSVLAQIPYKKKGGKSVTMKFVKDESAKGDGVYKSHVVKICSGEPPSSQSAPPCAVKQTTTKKAVAAPKKINNTPRPAAHHPIAANTSSIRSAPPPPPPPTASVATPTPPAPPAPPATPSLPQYKAIYPFKSEEQGEIAFEKGDLLEIVEKDENGWWLAKKDGIEGWVPSNYLEEYVAPKAASPPPPPPARRAAPLPPKTINNNNHTVSTPAPIPSTNGVPAWKAELEARKANAPVPATRRAPPAPGPKPVVPVKPSTMNKPVVPARPGGVPTPAPRAPPRPGAAGAAPSSAAASLADALRARRNQTTATHHDEDDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1F4</accession>
    <name>A0A367K1F4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000438">
        <property type="protein sequence ID" value="RCH95721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1F4"/>
    <dbReference type="STRING" id="86630.A0A367K1F4"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="13924" checksum="EED4CC27CBE45358" modified="2018-11-07" version="1">MCKHILNAQVSIRAPCCKKWFDCAECHAAVSDHPLRKTNEMVFACKKCKKAFRKDMTDYEDEDEYCPHCDNHYVLDAVTPEATLGIETEDIRVDNRVIRDDRVKSKQGPTSIFDVDASNILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1H7</accession>
    <name>A0A367K1H7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000405">
        <property type="protein sequence ID" value="RCH96063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1H7"/>
    <dbReference type="STRING" id="86630.A0A367K1H7"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16617" checksum="EBD18AB4E3C06E3C" modified="2018-11-07" version="1">MSVPNDYKSAPSWPSLYWPFQPGYNPLVMVADKEHSLYYINDIWRFTMIWSLLFSLVVYLPAGVWAFMMFAKSRTLNWYTLIMIPFLFVIGGAIASFVIGSIIGVAIAIVYNAGFFVMSTWIPFLWALIHILIVIIGSYSTITAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1U3</accession>
    <name>A0A367K1U3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000397">
        <property type="protein sequence ID" value="RCH96146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1U3"/>
    <dbReference type="OrthoDB" id="2369094at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="549" mass="63796" checksum="DD0ACB23AF4298FC" modified="2018-11-07" version="1">MSNNQQLPDDIIEHIFRHASRAEAPTLRFLSLKWHPFFTQRLFSCVYFKSSSMFKAFLRLNKACENTRLLNIGLFVKAMKIDYPTYRTRKTISSKEFIQLVKYCPNVNTLIGSRELFDNCLSSYLLAIGDSIKWSIRQLCFSSEFELKHYYKYKDSIISISELQEAPDLQFIKSFPMLKSLALPSNLPLTTMQDLMFVFDSCAHLSQFHADINIDEDIDVRTTLGLYPSLLSVHFNSHGSFISGTVIDFIITRFINLCNISFTIIPLPLCRPLFATYGQLLGFLMQTPKTSFSLEMSIEKEEEGQDFEIISNICEYFNNYVRVVSMFTNRRNFLEILVDSCYSQTVSIKTTLESSTKNRPRPDRLLDDPFVLDIHELCIESPAESTKLSRSTSFFIKRCHQLQELQLSIHLLSFYGYVYESLHTLRIHAATVDVGFFQCMSASCPNLKELYLRDVRIVRYNPDGSAYTNDRQWINLQDLRLQKLTLNVFMAFVVITTDKGCRYYFVQGAQVREITVEQAMILAGRFYNEDSYYIYCRDDVEFDANMVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2M3</accession>
    <name>A0A367K2M3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000361">
        <property type="protein sequence ID" value="RCH96512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2M3"/>
    <dbReference type="STRING" id="86630.A0A367K2M3"/>
    <dbReference type="OrthoDB" id="2282757at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="687" mass="77575" checksum="3FA30F14244EDB41" modified="2018-11-07" version="1">MGLLNFKKSSRKQGQKPSPANPVTEPDRASILLHEFNYSSPTIIPKPSETSLMDDIMQELAASSFTTPNDSNRPTSPVRSSPPTPRPLRAPLLQFDQGPQSPSSTNSPTTPNDNTPVVPITNAVTSASETRVVPPRPLISFTNQPNVHSDDDDSDSDSEVQQRPQVQPHPVLRQRHSAPLSNKTLMTRMKERHRQEVRKTLASFKQEGICSSPSMPVMLSEKPRTLVQSQSFIIPSNNSPFPPMQPQGRLVRSTSVLTNMMPIQTQSDITVLTRHPPLPSSPSFIRQSFVQSPVQTLPVTTEEDEEEQVSAGSKKFQINRSVSAYPSFPQAMQEQQQIIRQQQQEEMKLKIELQEIKRQQELQFQQEIQRRQQQVIVQQQQQLQQLQQQQQLMIQQQQFQQQQQQQQILLQQQQIHKLQQSSLEMAKAAATAAAAAAASTASHKSKPAHRPLYERSSGAHKHKQNGHDAHNHNHHHHHDHHCSHNNSNSPNNKLVVMPHVVPSSPFTPEFVKYQNEHNDDEEDVYDEESLLSPTTVKVNKSARSSTSTLILKEEPNEHMEDNEKTSFKLPIKLKRELEDMQLSRSIYSVPNLSSLLTDVQPGCHRALGVMDAFGTKCAIKKETKIAKETTAMTTGAPVYLYYLNDCHHNHHAHHCHKEHHKKAHKKHHHCHRSSSKYTLVEGGAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2X4</accession>
    <name>A0A367K2X4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000357">
        <property type="protein sequence ID" value="RCH96553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2X4"/>
    <dbReference type="OrthoDB" id="2272325at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19983" checksum="42AD4472B52FAAEC" modified="2018-11-07" version="1">MWFGSKSTDYYMNNRDTYYPPESQGGFGSLFRRKSISASGRNNHRYPDDTRYRRNSLPTHHYDTRYYAGLPPGNGLSSFTKPFHDLDYYQQQGHTFLPHPPRPMVHNHNPYPHYGGNVGNYHGHHHHDHYGYPQEQQYIHRNVAVDSGYYPYTTGYVERPVRKVVKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K319</accession>
    <name>A0A367K319_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000384">
        <property type="protein sequence ID" value="RCH96281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K319"/>
    <dbReference type="OrthoDB" id="2215285at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016908887" evidence="2">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9529" checksum="DF9C517CE458234C" modified="2018-11-07" version="1">MVRVFLPLAAFIGLALALPVEQLAQSTPTTDSSTPAPRPTNFQHPSYNTQGLPESIFPDYSGIELGHTDGLHDVVKHMEMQNNGHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K366</accession>
    <name>A0A367K366_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000348">
        <property type="protein sequence ID" value="RCH96664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K366"/>
    <dbReference type="STRING" id="86630.A0A367K366"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="18643" checksum="EA567498F6EC0D5A" modified="2018-11-07" version="1">MPTYNNIRILHATTPKYFEKCLEVREEVFINEQKHPIAIERDGFDDICQHWVAVCDKVNEDGTIDADYPIGNVRLMPKPNGVAKLGRLGVLSSARGLHVGQMLVKAFIEYCKQTEYTTIVLHAQNDKRGFYERLGFKVEEGDDETFMESHTLHVRMWMRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3W7</accession>
    <name>A0A367K3W7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCR4-NOT transcription complex subunit 1 CAF1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000332">
        <property type="protein sequence ID" value="RCH96850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3W7"/>
    <dbReference type="STRING" id="86630.A0A367K3W7"/>
    <dbReference type="OrthoDB" id="2221192at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="1">
        <location>
            <begin position="144"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="262" mass="30092" checksum="87219524ACA9DC06" modified="2018-11-07" version="1" fragment="single">RLGEWPQFCKSIVELPGLVQTQPRFIHTVRRTLMRNRPISFTSIRLPVIPNAAMSELDGLFEVPEENTQRRLITAFNSIQKDNAESRIEEFTQVLKPTFYQWFSRYLIAEHITAGSDNQMLCLSILRHINSKLLDAYVSTAHVDTLTNLGSWLGKITLAQNKPILEKHMAMKRLLLQSYDVDRLTLVLPLVCRILKQGSYGQVFIPPNPWLMGILSLLAELYEYGDIPVRIASVYKTVLTIKLLQADINVASILRNRRLIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K615</accession>
    <name>A0A367K615_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000263">
        <property type="protein sequence ID" value="RCH97610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K615"/>
    <dbReference type="STRING" id="86630.A0A367K615"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="16955" checksum="CAFBB8C6F025DFBB" modified="2018-11-07" version="1" fragment="single">MTLTNSKERLTNKTSSCVIQPTILEYNGSIFEYSAYKPTMRFLRDFDSIFPQLSSRQKAQLLVVPVIQKCEHDMVGLSKEVNDERDIKLELFISWGRRVVDRIKSVGMWADMMDPASGFPIFSHPGSSPYPDVQGTVMLDSRFDVQNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6H0</accession>
    <name>A0A367K6H0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB3GAP1_1</name>
        <name evidence="8" type="ORF">CU097_004088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000253">
        <property type="protein sequence ID" value="RCH97729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6H0"/>
    <dbReference type="STRING" id="86630.A0A367K6H0"/>
    <dbReference type="OrthoDB" id="17346at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="7">
        <location>
            <begin position="711"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1035" mass="118615" checksum="E66E799FA00EF869" modified="2018-11-07" version="1">MSTKRRQSSYSAEEPFEFVDYTSVSNFERLVTHIEETLYSWGIKDGSFGIFSDEQISAAKAALSNPTAEEYTRKEVLSVDEDTFYFTYHCQPTVVESNNAPPLAADHFYQFQYNQYHPLHRWTGQSRLLILKLANDSIKKKILLGTRSSIENHQAKQLISACAIAFQNTGCSIPVFTPVGQERHKMFLGYMLTTSNMDHPLNETETRFNMTIISPPSTLSCLDELKYLFMQKQSALRETYGKVDYDDKDVWTTAVYTYDLKNWFENNWKQWPETPDTASERPSISRDLSDDFGQTSQKPLDETENMLPFGSYNDPLRSLTLSALFPFWQDGLYDDAQSTNMDALTAKQWVLSREFAPANQQRADLSNSIEQIIGSWIKDPCNSEYLAPYDEDNDESVNDRAMLLRNLFLANNSRSTSSSTSGSMADSTGGTRSGDEQVTVVKSDQIEEVLNNLFSRNKVPLYNNKAGKEDQKEMLDTKKLVLKFRASSSVPYGSFLWNLLLFTIKALANGNTNPNSRRQHFADFMGFFRIVWTEVLRKIRWHWENLEPIPDVSPYLYDDDNDEDHNCNDPKKKKILGIDLRFNILHQKLSMVNCCIYRQRQNNSSQSGKGASSKEQTILDNKSRSNLNNERPGQSKKQTRSPVIDDSDSTEEFFDTVEDVEGSINIVQRPVDEELEEPGSAHPLSESYVRLPFVAIFNNEEAEAAAIKDPNRAEGQLCEHTEGLKLLKTGEPLQVPVTQDPGFMTEDMVKEQAEAFENMGSSDRATLKRAQLQSRQLYSDMQAFKAANPHACLEDFVRWHSPRDWIVPEGSKNEEGHLSKRMSEPNNIWQELWNCSHRIPCSRQSPLFNIYTEAEKALFFLETTSVHELFSTMLPTLVLIAYDTLVNHPVVKHSRLVTDELLELRDVLIHFPWDDLRFGKKTIESITFQIRQVESMMCNAISLLRKLPRQYDLVDRLLLSEQTIVQEGQERSAVFQLFKNDDGIISKPSSREYVLYSSCNGLIGSDRYLPMRQYALVKDNEVRIVDLHTVDAIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K728</accession>
    <name>A0A367K728_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_001859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000233">
        <property type="protein sequence ID" value="RCH97977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K728"/>
    <dbReference type="STRING" id="86630.A0A367K728"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="40359" checksum="DE1074783C0E9594" modified="2018-11-07" version="1">MSIDDHNGLIYLLLGDNDDIKAKKAHDYIERLTTLSLSELQQESAQLKEEQEKAKQNAQRLVFRNYPSFLDSQACTKQISSLLGELDDNLNEFQKCADELEAACNTFKQDSKSIKEEQHKISCILDHEDVLTELLEIPQLMETCVWNGYYSEVMDLASHVRLLSVRYPLSVISSIQQQVQACFDLMLVQLISHLRKSIRLAAAMNAVGFLRRMDVFESENELRMVFLRCRHDYLQQRLSRIKREMSEDPKQRSRDSLEYMKRFIDVMREQMFEIGTQYIWIFPHEQGPLLSDYMMHLIGFIRSTLNEYLPLIEDDASINSLLTQFEYCSISLGRIGLDFRHLFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7L0</accession>
    <name>A0A367K7L0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">3-hydroxyisobutyryl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EHD3_2</name>
        <name evidence="15" type="ORF">CU097_012457</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000219">
        <property type="protein sequence ID" value="RCH98157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7L0"/>
    <dbReference type="STRING" id="86630.A0A367K7L0"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="65"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="446"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH98157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="533" mass="60870" checksum="3FC7C2B817C58C56" modified="2018-11-07" version="1">MSLHFKKKHPQQTNSSANSSQVFEDDQYAKVVDGIKKIYRQKIKPLEVTYNFEGFHSAPLTDSDIEAKPIVLLIGQYSTGKTTFIRYLLDKAYPGEHIGVEPTTDRFVAVMHGAEERVIPGNAAAVNQELPFRGLNRFGQAFLSRFQVSQTNSPVLENMTIIDSPGILAGDKQLTERGYDFTQVIEWFAERADLILLMFDSHKLDISNEFKMAIHSLRGQEEKVRVVLNKSDMVSQQQLMRVYGAMMWSLGKVVQTPEVMRVYLSSFWTEKPPNCFEDCRELIEAESKDLLRDLKELRRHAAIRKINEIVKRARLARVHALIISHLKKEMPSMFGKKKKQEALLNNLSAEFVKIQQKHHLPAGDFPNPERFKQNLAHYDMDKFKSLKEDLIERVDEALSTDLPHLMSQFPTANPELGQNERNPFQESAVSRPGEIPPSYWHFDSIDKNSYAPSFFQLGPRDGKASGTEIKPVLMQSGLPTDQLAHIWRLADFDNDGYMDLDEFSIAMHLIKAVQNGAQLPEKLPATLLPNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K858</accession>
    <name>A0A367K858_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)H-dependent D-xylose reductase (XR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">XYL1_2</name>
        <name evidence="7" type="ORF">CU097_005895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000203">
        <property type="protein sequence ID" value="RCH98356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K858"/>
    <dbReference type="STRING" id="86630.A0A367K858"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="321" mass="36965" checksum="F720B03923E215F7" modified="2018-11-07" version="1">MTADYVVLNRTGDKMPLRGFGCWKIPKDVCEETVYNAIKVGYRHFDGACDYGNEVEVGRGIKRAIDEGLVKREDLFIVTKLWNTFHNKKHVRPLCERQLKDWGLDYFDLYHVHFPIPIAYVDPSEKYPPEWFKKGKDTIELEASPMHECWAEMEKLVQDGLVRNIGVCNFNCQALIDLLAYAKIKPAVLQIELHPYLPQENLCKWVKAQGIHITAYSSFGPASYVTLGEHGKQAPSLLDHDIVNSVANKHKVSAGQVLLRWALDREFVVIPKSQNEQRMKDNFNILDIKLDNEDNKALDSLKSFNLRFNDPKVWFDLPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8G6</accession>
    <name>A0A367K8G6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000195">
        <property type="protein sequence ID" value="RCH98466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8G6"/>
    <dbReference type="STRING" id="86630.A0A367K8G6"/>
    <dbReference type="OrthoDB" id="63589at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="791" mass="89360" checksum="B0E5AD548E7CEF82" modified="2018-11-07" version="1" fragment="single">PILPPSLLPTDFLSTLVTLSQTKLNMYTHLAQFQSCCWKYWDISVPYALFEKKEFDRISPSFLGWWGPAKGVPMLVFVASDVLLPEATPATIKKMQEALQQRIKNIFRATHLIPSRQEPGNSSHAPVDVKSLFLLPSTSQPIIHIIPSIPKPSVETEYTLDEPLPISSYLEQLSVSEPGNLNDEYGDKLLRNFVTIWTKTAVNRHPLHRKMNDVKYVPLPTPIQFASSVVPLLHFLFNQPMRENNENFRDIIIAHYSSTKGMIQQIEVILRKKIKDNIEIERVFSKNYCYNVMQHCQEAYLQDSPPFYPEKYHAWKRDHALRLYASLARGPCKEEYASRLERECDLVWKENRQSCEHLSLTGRSCRLKTGHESIPSQSQKRDDRAIMTDSGKHSSGVTFFHACNCGRTQKLRDDPFDIMDANVKFYQRFTCCLGKDRAALDIKASVFGDNQHLELRYDDVPADDSALLLLGPASVYKNNVGLDNVEGFLNNTNYLIPWSITTVNDLKLYQQEQVEKKAKEAITTVLQPVPNQEEWPVLGKAPAAASKTTKVIPAPTAASLEAFPALGTNPPPVSTPAITPEIPVKQLFEAKENSNSRGSSRRRRYNRMRDRLQGLIRGYIGAEYECAQGHRFLSCGEGRVCKIGHAGHPKEHGNYFVHQDLNVFILCPCCYTPSGNGSNAAISSSSEVTAQLMRLYVVTPDEDITISIEPKIKINIPGSDKSIHVDLGIRDPLYLGPGGAYVLRLPFIYRDENGLPIPIETDIERRMASAVLQKDYIKFHYKKASKWALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9B2</accession>
    <name>A0A367K9B2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000167">
        <property type="protein sequence ID" value="RCH98832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9B2"/>
    <dbReference type="STRING" id="86630.A0A367K9B2"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="572" mass="64093" checksum="F3BA19A542A61CE1" modified="2018-11-07" version="1">MDYSSFSLQESSTSSSVDMFKQQQGVNGHESMEFINFMNQSYNTHNNNNSNNSNNNSMTNNINHHSNNNNNGLFSVPQLTPDGHQDNSFTGSSVLSGHNPEYNMSPLQINNHAANYTPIQHPLHNQTIDDFGDEEEFLTPLVSPAMAPTYNNNYHFNTSTDNIFSPLTSPALHPSSSSVMDQHLLQQKLALIERQQQQLRSMQHQLNTSSTDSPTTSPLVTYSVESRKKSLQPKITAVHSPQTKLGLVKKIPESSPLALGPSNNSSMMAPATPSLLMKLGAGNNSNNSTPPTSTSSPLPSTAVDNMPVLPAAILQDDNTATNKAKAVSNKRRRISQTKFNHSPGLPPSAESPAGLRPLTSPRTLKPLISPSLKPNGQRLSTIDEEVARTLLTTKSNYENLKEGNVKSLGLDFSTTIQSGIEHRRSAHKAAEQKRRDILKQSFDSLRTEITEAMIEEELAEDQHMDQAELRNNKERDVKQMSKIVLLQHSYEYIVRLKSDNKRKDEKMKSMKEEIMSLRKQLGLPEITKEEQEQEEKERQEEKERRQERLKRLQQQTASITHNNNAIINNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAU2</accession>
    <name>A0A367KAU2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Cytochrome c oxidase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">COX2_2</name>
        <name evidence="19" type="ORF">CU097_015561</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000133">
        <property type="protein sequence ID" value="RCH99287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAU2"/>
    <dbReference type="STRING" id="86630.A0A367KAU2"/>
    <dbReference type="OrthoDB" id="539285at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13912">
        <property type="entry name" value="CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.90:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034210">
        <property type="entry name" value="CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="Cytochrome c oxidase subunit II-like, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0186">Copper</keyword>
    <keyword evidence="9 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II transmembrane region profile" evidence="18">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="17">
        <location>
            <begin position="115"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH99287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="233" mass="26394" checksum="F82F762ED3896397" modified="2018-11-07" version="1">MLNMLKSLNIISPVWNDAPEPWQWAFQDGASPSYEGIVELHDQIMFYLVVILFGVSWMLTSIIVEFGSNKNKIVYKYHNHGTLIELIWTITPALVLIAIAFPSFKLLYLMDEVIDPAMTIKALGHQWYWSYEYSDFVNEDGESIEFDSYLVPTDDLEEGQLRLLEVDNRVVVPVGTHIRFIVTGADVIHSFAVPSLGLKIDAIPGRLNQTSVLVEREGVYYGQCSEICGVHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAU6</accession>
    <name>A0A367KAU6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000132">
        <property type="protein sequence ID" value="RCH99298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAU6"/>
    <dbReference type="STRING" id="86630.A0A367KAU6"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="42229" checksum="6707195F043C1A5E" modified="2018-11-07" version="1">MTSKKRTLFFSIFTFISLSTLLWNQFNTTKLRSVNNTSDNRVKACYVVLVRNSELDGIIPTMRQIEDTFNKKYNYPYVFLNNEPFTPEFMDKVRLSTNSDVLFGEIDQSMWGYPDHINQTYAAERRKEMEMQGVPYGSSESYRHMCRFQSGFFFRHPLLDQFDYYWRLEPYVDYYCQINYDVFRFMKENRKKYGFNMALKEHIETIPTLWDTVLSFTRSTYPHLLDRNDSLLRFITNDGGLTYNTCHAWSNFEIGDLSLWRSKEYLALFDHLDQSGGFFYERWGDAPVHTIAAVLLLKKHEIHFFNDIGYRHSDYTHCPVQQVYRTMCSCDPDISFDFNQNKSCLPFYLDAMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAX3</accession>
    <name>A0A367KAX3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Berardinelli-Seip congenital lipodystrophy 2 (Seipin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BSCL2_2</name>
        <name evidence="9" type="ORF">CU097_013899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000126">
        <property type="protein sequence ID" value="RCH99393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAX3"/>
    <dbReference type="STRING" id="86630.A0A367KAX3"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="41630" checksum="69146813084D178B" modified="2018-11-07" version="1">MSNSSGKAFSDTDDYSDQGVPSSDFHVVPSTGSQSFENESGDINEKLIIGEEEEGEEEKIKPIEWHPALVITGNLLKKLMSPIFKVLFAPQAQRTFIKTFVVVILVAWILLTSFTAYITFYQRYIPKNAHVEPIYFQYKKDSQPQAFIHFMQPDSNSMPLRSDQAYDVSVQLHVPTSDINFDIGNFMIHVDLLSQNGTVLAQSSRPAILRYQSNTQRILRVFAKAIPLLIGWTEESQRINVHLIEEFIEKKALPMTHAKVALSTPKLQLYDAHLSVVADFRGLRYYMYHRRITTAFVFMILFTVIELICASIAWKAFGKSLWDKLHDAFAMEPLTAEELPQDQPQQETSTQSHHTDDDEYLTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB17</accession>
    <name>A0A367KB17_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000125">
        <property type="protein sequence ID" value="RCH99414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB17"/>
    <dbReference type="OrthoDB" id="10364851at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016719073" evidence="2">
        <location>
            <begin position="22"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="327" mass="32634" checksum="7F13D52FB713066F" modified="2018-11-07" version="1">MARISQICLALLAVAFTATSAAPCYDGQSSVSTVNSNGSVTPITQVDVTKDADVDNDEAENDGDDVSDAVDTSVDVDASVDDSVDDSVDDSVDDSVDDSVNASDNTSDKVSDNVNASIDVDAEATTDSAPCVDGDSTDIANVSTDDIKDTIDVITGHSSTSVTHGANSVVAAADGVNRNSLLGVTTGYIGTGPINLDNLATNALSSGNFGDGIYQAQANRAPSVTSVESGNGGGLLDITAGYVGTGPISADNALTNLLASRSNGPFYAQSADSSDALSTVDVNDGNSASVANIDAGYVGTGVITADNLGTNLLSGDGTNGGLLNRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB45</accession>
    <name>A0A367KB45_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000123">
        <property type="protein sequence ID" value="RCH99444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB45"/>
    <dbReference type="OrthoDB" id="10272103at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016858949" evidence="1">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="15308" checksum="BA0724FD23E76F30" modified="2018-11-07" version="1">MYKLLLIAIFTLFAYVNCDNNWIRFKIDQWPNNYDESIYYKVSINGGKEFSWGNGVKMYSDGNESCKNGLCVKTYLDAGYIDFSYAEKKVSHPNSWKRTIEFAFWNPKTEKCLIKRSAYLMSGYRELPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC20</accession>
    <name>A0A367KC20_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHO1 GDP-GTP exchange protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ROM2_8</name>
        <name evidence="3" type="ORF">CU097_010268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000100">
        <property type="protein sequence ID" value="RCH99782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC20"/>
    <dbReference type="STRING" id="86630.A0A367KC20"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="110"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="806" mass="92196" checksum="D41C57CC8763BB6D" modified="2018-11-07" version="1">MDIISYLLYEQDELVHTQLLDTFVHHGLLLYQEEYYIVNVQKIVTGIFLPLTHCYSPTCHPTNSQCYSSLCPNKQFTINQLIDQEHIQQKEWISSIPRCIIDSVSRKELKRQAAISELLLTEQHYIQGLVILHTVYGTPLLNSHVIPEPQRRQEFYQRVFRNYLEITQLHHSFYNTLLSKKRRSAPLLGRIGSALLQHVTRLMEPYIIYTSSHIRALHTVSTEVKHNLHFAKFLEKQDIVKFTGRLGFHHYLIAPTQWIGKFKLMVEAILKHTEDDGDELALNVSLSLMHDILCCMNNKMQEKHIIQLDFRLYPSNSVLQLPTNTKLLLEQDVRLISPKNPLQWFNCHLFLFSHALILTYSKVTREKASYIVVPGFPIPVQMISIRSDTSLSLIRRISQSGFVNGIRRHRSVDLVKGNSQFLGPVHQQIKTKLSSIKARRFPTTSTIVPAAFTETTTVSRRKPTYVSSVSFTQTKGNASTFNHSVDISMKRRTLTISHLANPQYTFKLKFSYQAQKANWQARIQQAVTDSTQYVPFRPVKLELEKHFMHSLLCACGFSYLNQSFIVFGTSSGVYMMPIEGTKVRCVISGKNAKQLGVFGDELIVLMSDILLAYRLEVIVKAYECISDPLDYAVIKQSCVVCFEIGTVHKQSAIVFASGSPGQEVKLSTTILISCAKYRFKKLEKIGLKQIDGGMLFDGESTGVVVFEKKKYIYDGQNVDIFPLFSHASLKRIKFDCVIHQLVVCYPFLIAFCSSVIEIRHIETGDVVQAIPGDNIQYISSTSRFVLFNMSPSKEVIQLYRLQKNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD75</accession>
    <name>A0A367KD75_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL26_2</name>
        <name evidence="6" type="ORF">CU097_015175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000079">
        <property type="protein sequence ID" value="RCI00129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD75"/>
    <dbReference type="STRING" id="86630.A0A367KD75"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="129" mass="14757" checksum="2EAF0C400A5F157E" modified="2018-11-07" version="1">MKFSADVSSSRRKSRKAHFTATSDVRRKIMSSPLSKELREKYNVRSIPVRKDDTVMVVRGTYKGREGKVVQVYRKKWVIHIDRVTREKVNGATVPIGISASKVVITNLKLDKSRNAILERKGKKDAMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDA6</accession>
    <name>A0A367KDA6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000076">
        <property type="protein sequence ID" value="RCI00169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDA6"/>
    <dbReference type="OrthoDB" id="3260152at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007980">
        <property type="entry name" value="Ribosomal_uS3m_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05316">
        <property type="entry name" value="VAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="250" mass="28242" checksum="589650FE210EB22D" modified="2018-11-07" version="1">MSKSIKALSLKGKQDWDTSVFCFSRNVRNNMIWEKDAAAKATLKHFFQKHLTSTPAFKHSPSRVTIQLFYYVDPAFGNASSFKLDALEKLIGSFYPNKFVDLRLTQLHYPYMNAEILAQFLTVNAERNGWSMVNRRFFKTAPIVKAPLPHNMPFATQWTSLLPQLSNGQLTSAIQGIKYQVSGRLGRRKGASRTQVMRKSLGTFQFTSHKSLVDVGRHTFANKNGSITVKVWIATALFGVNTAVKNISKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE85</accession>
    <name>A0A367KE85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000057">
        <property type="protein sequence ID" value="RCI00499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE85"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="91"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="403" mass="46652" checksum="DD224E36B4017997" modified="2018-11-07" version="1">MPSTPIPISIPRYDMPSYLQEQSTYMNSLTHIDPTAQTSSSRRSSMSSKSSSSCDHLYKPTLSHKKPNTHQALQMPLQRAAASVGPVRPFSQLQMAKSYNFDNISCGLERGLEAARGHKGEVLLSAKIGKVLWTNVKKEISSSLWKFHDLRDILMSVHGIQPYFNDVVTSDNNMMNELLHILPTPTKPRRYYEFYCNSRNQKRMSYQPIIIQMKDAIIEAQKVIYSQKVVTEIDWMCLDRKLDFQLSLKVQDHIRRDVKPIKTFVKKVAMNPTTGALIYEDVPNFLRVKKVLLKETTQYRIQNYVIEVTRVEKLARREAPMNEYQPRKQIIAEISLDDHWYETEIFDTSHSNFFDINKSLGVAKAASWKPDDILGKDYSSLRRLIAFILTFIEQAEEKYKMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFM5</accession>
    <name>A0A367KFM5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000029">
        <property type="protein sequence ID" value="RCI01015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFM5"/>
    <dbReference type="OrthoDB" id="2203732at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8546" checksum="97B6F8805FF24F89" modified="2018-11-07" version="1">MSEKKELPPDRYYTPQVQSSVSHKPPSIYQPTPKPESVIVHEKTRVHKNNSCCISCLLACFICLAVKDEGTKTAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFR6</accession>
    <name>A0A367KFR6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_014255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000029">
        <property type="protein sequence ID" value="RCI01007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFR6"/>
    <dbReference type="STRING" id="86630.A0A367KFR6"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="505" mass="57639" checksum="9AD89E4E53FC6C26" modified="2018-11-07" version="1">MLTHIKDFIRLKKEEYRTRHINNTINHSSHQQRLMESRTVPKQQALNDIFDLQRKQNNNTGYATVPRSVSVKEIKRAPNAAEELATMVMEQNNKKRNQLPHNEFDRFKLLKKIGDGAFSNVYAARDIVTGKKVAIKVAQKPKAEKVSFYFLLKSMDIKPENILFDPIPIIPSKHRKLRPTDNESKMDEGEFIKGYGGGGIGRVKLADFGLSKVIWNNSTFTPCGTVGYTAPEIVCDQQYSKSVDMWAIGCVLYTILCGFPPFYDESIQSLTDKVAKGEFTFLSPWWDTIGRSVKDLIRHLLCVDSKKRLTIDEFFNHPWITEKEEDIKPSTGLQPSAREQIRLNQSHKYHPYCHGEQELTPPKDQEDDAVMVEAPYSTPDAATLREIFDVTYAVQRMGEEQPDAKHHHHHKQAHKEQSLNKTVANKHVPVPQTQQNQHLPIAQKLAQHSRGVANPIHYQHQQQPYPHQSGASPVAAPTLALNEFKLDMNKATLLKNRKGMMKAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGJ2</accession>
    <name>A0A367KGJ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNF1-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SIP3_1</name>
        <name evidence="9" type="ORF">CU097_012961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000014">
        <property type="protein sequence ID" value="RCI01343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGJ2"/>
    <dbReference type="STRING" id="86630.A0A367KGJ2"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="978"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="289"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="765"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1075" mass="123404" checksum="0D1FB99BB0185C6C" modified="2018-11-07" version="1">MSTCLVSLPTNVFTIQDVVLDSPVWRANMTHLEDQIDQYEKWLDGFIRALKTYIESVTKCHAQATNLCKRMFISGLDSDLSDFNMVDNVINKFATTLELTLHYRTQLITELEEALLDPLQKLYKQDLKSYKESKRQFEKTLDKYETQLSRYFVLSKQKEPSALREDAFQMHELRKAYVKQSTDHFVKLIYFKSQLEHILVQSFSSAVSAHVEEIEETRRTFGTLKPKLAIWKQWLDENKTTCEHQINNIKERCIELSDTYLQQCTPHRSLKRYSITQYDDIIENLHETVIGKEGYLNSRIARSTWVRKWFFLQRGWFGTMTINKQKALITLGDRVLVSECTYKVVTDVDRRFCFEITHPKNTFYLQTETEEDMHEWIKAFEYQIKQNQEQEEEQGKVLPMQPLLYPSTLMTLTDDQFVAKVSSTNDLIPIHSTTASLLTSLMIQKGRSANEEAIPVKSSNNTSNSSILSSWGVSWANLSNEEPTESQTDSCLVWPTKLEMEVNGPELEHYTLDARHRELRKLFANVPQNEIVLDAFKASYYGQKGDETQYGYSGIVYLTQKAIWFYSCTLMTSLHLCMIPLEKIGSIKIEKTVNGTWLILGDILFSLWSCTPSEIIVERLKITASQKIQDIQTLYDTIRNISTTKISNHVTTTSALFPSVTPLTIQIQQPPVMKSNSSTSTSNSLDNDEGDTESGPSAAHDALKAAYQSSSQHQQQQTSSITNVATTATTATNGTNNIHEDDDSNWPDSIPQPDNQIECGCKDHLDKVEAEVVLDLGAKRLFMLLFSDTAVWSQLNKVAGFGEPTFTEWANSQEEGVIRERTLTYMMPVSNPMVRAKETQVIGTQQILQEQDRLTYIVLVSTKTPNLPYADTFLPSIKYCITYVAPNRSKITCSLGIKWLKSVLVKSMIKSAAMKGMAETVNTLIPILQQQQQQQQLQKQQGPEVAENGNGQIKEKPATERIEKAPVRTEGGALWDKMTVLNLCFIFLCFLLTIYQFRMQRKYEALVDHPVNWKGVYLRDLQNITESQITLHRVNPTTYEMFQQDRINLVDWRHAWSSRRHQLMALELSYARERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGJ4</accession>
    <name>A0A367KGJ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_013755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000016">
        <property type="protein sequence ID" value="RCI01297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGJ4"/>
    <dbReference type="STRING" id="86630.A0A367KGJ4"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI01297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="515" mass="57817" checksum="ED5F1D80F6795576" modified="2018-11-07" version="1">MKPDDSCIIGLEETVIETDEGVTRHSFQSTPSTESTCDEESMEKEPYTAFSMPQQILFLAITAFTAMMSPLTANIYLPSLNQIQRDLSISTEKVNLTVTVYMLMQALSPSFWGTLADSLGRRPILMSTMFVYCGACIGLALTPNYIALICFRMLQAFGSSSVIAVGAGVLSDIADIKRRGSYFGIYSIGQSSGPVFGPVLGGIIADTLGWRWVFWILLIIGAISLASVALILPETLRALVDNGSGYANPTIWQWYARRHGKLDEKRIQEVKARCNKRPPMNFFKPFTYLFQPDVFIIILYNGINYAGLYCYLTSTTKQFSIYFSYLSELEIGLCFLFQGVGVILGSFVRGHILDYDYRKTKEAFKEKHPDQPDTEMPIYMARFKKAWIHILFFHTITFFYGWCFQWGTPLYGILILQFFVGFNYSAISTTTQTILIDLFPGKGASITASNNLIRCLLGAVSALFIDIGIEGLGIGWMFTVVASIMTVSNICIPILLIFGPAWRRRRTERSQRDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGK5</accession>
    <name>A0A367KGK5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase-like Early set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000014">
        <property type="protein sequence ID" value="RCI01354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGK5"/>
    <dbReference type="STRING" id="86630.A0A367KGK5"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016919088" description="Galactose oxidase-like Early set domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="427"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60447" checksum="D79E1A10F45E686E" modified="2018-11-07" version="1">MKLQLAISVVLASVLVQAQSPFYYSFSNTTSKYEETGKMEQIGRTGVAAMHAVLLNEKSILIIDKAEENEAKLDSGVSAFSTLYDIEKNEYRTLKLETNTFCSAGGFLANGTFISTGGAESRSKWNAQRGHQSIRHFMDGEWHEYGQMFVNRWYPTVEQLPEGDLIIIGGSIQGTKWNTKEKNSPSYEFWPPRTTEPITLDLLLHTLPYNLYPFVFLLPNGHLFIFASTKSIIYDYNNHKVIKELPEMPGVPRSYPLTGGAVMLPLDPEKGYQVEIVICGGGPHPPRRDKLADNTCGRINLDDEHPKWEMDTFVHRRIMPDGVIMADGNVLWVNGCQRGYAGYNNANHDPTFDPLIYLADKPKGHRWQQGLANTDIARMYHSVALPLPDGRVWIAGSNSVDPPDIHAFYPTEYRVEYFSPPYLFKPRPRISHVPRVVEYGQHFEILFHFEGSDSVDPKKLRVAVMRPGFSTHSMHMSQRYVYLVHEFKGQSIEVTAPPNPNIFPPGAGYLVVVYDGVPSKGAEIFIEKSKNDLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGN2</accession>
    <name>A0A367KGN2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGN2"/>
    <dbReference type="STRING" id="86630.A0A367KGN2"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="771"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120732" checksum="3A631CA0E6165B1F" modified="2018-11-07" version="1">MQIMATTPITKVTTASLSQFNKHTKSSHTRRNHKTVSLSSSRRSSSDTVSSTSKSKANDVFEIVYAAPSDMITPPPSPKSSPSAASFAANDRILTARRQGHLKYLMAEYNALKKEGLMLHDHTYNLVFESYTALRRDGTPLASMLKIFDEMIESGIQPSSSTYSILIRALCKRDVEVQKVIAMLKRQNARSCSKSSSSNMAELESEGNITKALSIFDAAVGQGLVQFFEPELYNQILRVLSHYGNTEASLHVYEQLNLHASPTSATFAALINLFGRVGDLPSALKYFERYCELKDTFGYHDASYIYNALVDAHLKCNQLEGAMKIVKDDMLNCNVKMSTIPFNSIIRYYCIHNRMDEAIDLIESMKQSSPDPDASSFGPILSTYCQLDAYDEASKVYKDLIKTDISKSYGNLANYALLCLKHESTNVFQVLDDMRSAGLEPDPSLAARIITHFANASDITQALRSLRIILETMKPRTLAKGFYHIESASLSIVSAAETRFAQVFEVSRVLYPYCPQGLPSSIAKVLVSSYKGDNDHSMLLQQSDYSILFDASFSVSSESFQSIVFDFYAEMIEKGIRITPVLKARVFSHLQALGDRKAMKEWKSLFVERSDEQAQSVEAEEASQAVMKAAVHGQLQEALDILRTRIVEPGLVPSVESLRDAIAFIGKQGHLDIAVAMYRLCIKSLKTCNMESQQLSKAIYSMTNSILIGYAQQGDILNAKKYYEQIKLMGRYPDGNGYASLLLGSAKCATDEATDALLIYDEAKRHDVKPTTFFYNVVISKLAKARKLDSAMKLFEEMQQFNIVPNSITYGAIISACVRAGSESLACKLFNDMLASSSFQPRVGPFNNMIQFYVRQQPNRERALHYFAELRRRHIKPSPHTYKLLMEAYCMIAPYDMPTAHSMLSEMERRDNIRPQATHYAALIYSYGVLQRDVKSAGLLFGDMEEKRIAKDEVVYQAMLDTLVSNDRLAEAEELYVMMKQTIQRSSSPYIENIFIRGYGQKGLLEKAKAMFDAMSDDKDSDHDFVVIREPSTYEAMVRAYVENGKKEQAKAIFDLMLQREFPEKVTASVAELVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGZ4</accession>
    <name>A0A367KGZ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATP1_2</name>
        <name evidence="11" type="ORF">CU097_015960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000008">
        <property type="protein sequence ID" value="RCI01486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGZ4"/>
    <dbReference type="STRING" id="86630.A0A367KGZ4"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="10">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI01486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="15507" checksum="862BD385870B15D3" modified="2018-11-07" version="1" fragment="single">MLRNATRLARPTLAALAKSTPARLNLGAASVLRNYATAKPSTSEVSSILEQRILGSSSEADLQETGRVLSIGDGIARVYGLKNCQAEEMVEFSSGLKGMALNLEADNVGIVVFGNDRLIKEGDTVKRTGAIVDVPVGPGILGRVVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGZ7</accession>
    <name>A0A367KGZ7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000024">
        <property type="protein sequence ID" value="RCI01122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGZ7"/>
    <dbReference type="STRING" id="86630.A0A367KGZ7"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="306"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="485"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="714"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="111154" checksum="FAC046D4551B28EA" modified="2018-11-07" version="1">MRGFKTTLELKIFKRASTSLLCALEMTEVEPIIVKRIGAKYISYSHTLFAYSAFLIALAVGCYTHYYKIVQNEYFGYPDEWFPSVSATTGDRYPARAIFQIFIALTSGPRFALVFLWYFYTTQSAKTVSNGFGLFLLSVGIIRTVACGGWVYITSTDDHLTHDIAMILYLLCTLPWQLGVLYSSAKANQTAVKWRRSLTSAFFITLPPMIYFFIQHKVHRIPGAYTTYAFFEWSLILYDVAYDAVTAIEFQNFELTIIDKSPNLATAALSSSSVPFTANPEGNIDASTLRTLTMLRGFATETYLAFVFWSMLTSLALLIWYFPLWYMGISGYEAFLLITLLPVFLVIRPLRQLVYKYRGLVHLISLVGVASYLKVDPVWRLTLSAIGIGLSLTAWVAGWIESNGQTGELERSVLIWGLGLIMHCVVKMAWYTENPIWPIMNRQNGGLNDVGLVFGVVASADVLLRDFSNGRRSESSNESAVRYPGSSLLAGLGFGSLLFALHSMYTDSSTIMRWTVDGYPNYGPDPVPWGIATIAALGIGLAISPYRRLTTSFGWYAVGAASCAIFYIYSSWTAFYGGLVLGTYLTSIMPAMTRGLSTQSPFVTLFSAFMTYNILCLAHVWVVAYEFVPGGVYARERTDVILCSVMLLIGLGVFNANKQARQDVQKRLAQFHILKHARFMTRILIAFFIGISTLVSTHRLMNTTSPAPYTTSEKSFTAGIWTIHFALDNDMWASERRMRDAIRDLQLDVVGFLESDTMRIIMGNRDWAQSIAEELGYYLDFGPASMKHTWGCLMLSKFPIIKSEHHLLPSPVGELACAIHATLDVYGQPVDFIVSHNGQDENYNDRIQQTTKLAEIMRTSPNPFVFLGYVVTKPQQEIYHLLFDGGQINDIDPTDWDRWCEYVGYRGLRRVGYARISHGGITDTEIQSGKFQVVDNPKDYWKASYDRIPEQEVKPELRYPSMFYGQGVRGHRYHVFDEPRYFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH20</accession>
    <name>A0A367KH20_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000006">
        <property type="protein sequence ID" value="RCI01525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH20"/>
    <dbReference type="STRING" id="86630.A0A367KH20"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="71"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="71"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="455" mass="50956" checksum="2B496C7AAAD78159" modified="2018-11-07" version="1">MANFMPLPNPSFTYHGTEYTPSPESIMSSQMQPSIMSISEPETPRPQEHHSPTIASAEKMAVPPDLIRRGHQTLPSRPEGFSTTTFPSNPAGPIRRRRTESFFSFEMGPSFSSTKQLHELCNLEQTNDYKVQLHAKMDRGFFKAELDWTCYRRNYFQVSATFDMHGTNYMLQGPEAPCLLRKADTGEILPVDYFSIGIHARVANHDKKIELVQHTPKRDKGPQMIPQPRPVRAGGNLHLAAVGTNHNIVTFERLQFKTATANNGKRRAAQQYYEIVVDLYANLSRGEPICVATCHSAPLVVRGRSPGHYADSHTRFKGSEDAFASPPHRFASSMPNSPTRDFGPYHAYPFSLGAAYPPPPPPPPPPIVHPSSNVFLPYQQNNTTNDPNGANVYFSNSSVEPPVYNTADPYMMGARGKMPVNNSHWAQPQSQQQDRFYDPYGRQEDYSSTSTSTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHA1</accession>
    <name>A0A367KHA1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Respiratory supercomplex factor 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RCF1_2</name>
        <name evidence="8" type="ORF">CU097_015959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000005">
        <property type="protein sequence ID" value="RCI01557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHA1"/>
    <dbReference type="STRING" id="86630.A0A367KHA1"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI01557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="100" mass="11140" checksum="25E76F489489DE03" modified="2018-11-07" version="1">MKEYSREELERMRIAMNGETALDKIKRKCREEPFVPAGVALTCFALIAATVGVKMGNKAYANNMFRLRVAAQGFTVLAMVGGSLYYEQQKKGETEESPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJ15</accession>
    <name>A0A367IJ15_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005769">
        <property type="protein sequence ID" value="RCH77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJ15"/>
    <dbReference type="STRING" id="86630.A0A367IJ15"/>
    <dbReference type="OrthoDB" id="2260598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16623" checksum="6E66CEF066E3CED4" modified="2018-11-07" version="1" fragment="single">LSYGPLADTNSIVSRIRRNRVVQPQFSHPEGSRVAASVMARHLQQVFSGANLPDTRYSAPPIPTGPHSIDEASCPITTSTVHYALLKRLSRRKAPGVDHLRTEMLLPIADEVIPTITLLFQLCWKWSVIPSDWCTAQVVPIYKKGDALDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMB0</accession>
    <name>A0A367IMB0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004905">
        <property type="protein sequence ID" value="RCH78805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMB0"/>
    <dbReference type="STRING" id="86630.A0A367IMB0"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="236" mass="26572" checksum="665F26BFADAEB2D3" modified="2018-11-07" version="1" fragment="single">LTDHRDRLMLISEPEAAALYCERTCDKFDMKHGDEFMICDAGGGTVDLIVFRLEKGLDGKTVFRESTKGLGETCGSMFIDLNFRKLLRKRLKKVLRPSANGKVEIPSAPFEHMMDVFVDSSKPLFDNTDDIYCSLPMGFDLLRKTDPSIGLDEGTITFTKEEIKKHVFDPVIQRVIGLCRQLQKDTTNLKAIFMVGGFGSSAYLYQQMVKEFSPEGIKIIQPDRPEMAVARGAVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMC5</accession>
    <name>A0A367IMC5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004897">
        <property type="protein sequence ID" value="RCH78819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMC5"/>
    <dbReference type="OrthoDB" id="2289482at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="254" mass="26974" checksum="FA9B68AFAC8D3879" modified="2018-11-07" version="1" fragment="single">GKCNGKANPKPPTDPGNDKCLCLVPSNKGMGTGEGWKDYCCENSDDCLDTCIKGKCNGKANPKPPTDPGNDKCLVPSNKGMGTGEGWKDYCCENSDDCLDTCIKGKCNGKANPKPPTDPSDDKCLVPSNKGIGTGEGWKDYCCENSDDCLDTCIKGKCNGKANPKPPTDPSDNNDNKCLIPSNKGMGTGEGWKDYCCENSDDCRESCIKGKCNGKANPKPPTDPSDNKCLVPSNKGMGTGEGWKDYCCENSDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INH6</accession>
    <name>A0A367INH6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004733">
        <property type="protein sequence ID" value="RCH79051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INH6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="65" mass="7436" checksum="05FF1FBD1E88F8C2" modified="2018-11-07" version="1" fragment="single">MYANKINSLENQKYLAVRSIMPSSSASRKSVSKDNLRPLELRLLDSSQSNFNQGLKQELANTTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INK8</accession>
    <name>A0A367INK8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004631">
        <property type="protein sequence ID" value="RCH79223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INK8"/>
    <dbReference type="STRING" id="86630.A0A367INK8"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15458" checksum="38EE9D4339F49FAF" modified="2018-11-07" version="1" fragment="single">GKPLVKFENANVYRFGSKEPAFKNLTLTLNSHDRLVIVGPVSAGKTTLAETIAGKHLIQPLSAASWPIIDKSISPYASDFIHLVSFKESSGNFSYSKHYYQERFNFSDPDDDITLESYLNGDGKYNVERVKEIAKQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPB9</accession>
    <name>A0A367IPB9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004431">
        <property type="protein sequence ID" value="RCH79540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPB9"/>
    <dbReference type="OrthoDB" id="10337801at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016784749" evidence="2">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="232" mass="26412" checksum="3E2D25ECE1FAD66C" modified="2018-11-07" version="1">MKIGLVELLLLLFFSCTFCETKEVMLLSLLVFAYLHEAMKLIRRQKDEKAQDGTSSQAPHRQSSHIDQQMQLKLDTISQEMVCIKETMNEHIAYMKQLVNQERVNQETTHAREIVSRDIAQIKHMLHEAMVSQELGHQNIAGIDVSLKHMVGTRLASVQDKISHLEKSIKQIHEQQQAKVKVEEPSNEPESPSLPASHPVIIKEHSDDPLDSLPRPPSTDSIKSDPFEIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPV9</accession>
    <name>A0A367IPV9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004337">
        <property type="protein sequence ID" value="RCH79705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPV9"/>
    <dbReference type="STRING" id="86630.A0A367IPV9"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="253" mass="29231" checksum="327F2E6703E5687C" modified="2018-11-07" version="1" fragment="single">YQMDPADLVCLTALIGRDVRQLLQTLELYRDVPHPFESYLSISPQMSMTELKSRSIPSKIAVDTYRLVQCFESVVHHDEDEDMAESSQESLEDILDALNNDGFIDIWVGSRERRLVVQTSTDDSIIGYTHLVIDEEESVLNDIQIHATALNHVSNNTEFNESLWDELEDARQRAYEVDVEAIEKILPLRMMYRHDVIMTEYIPAIRLMLDPVRTGVLDSRSRQTRSKRKRIHLPLDDDSVNILTESKELVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISG9</accession>
    <name>A0A367ISG9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003808">
        <property type="protein sequence ID" value="RCH80640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISG9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="91" mass="10462" checksum="5067CA7E3A5D81AE" modified="2018-11-07" version="1">MPLPVKRFSLVEEVHEMVLLPSIVESLMFVKNELAAAKKRLGEKKTRKEKKVAKERIRPSFMSADEPSQSDDNQRGQKVTEEHNKKVCILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITN3</accession>
    <name>A0A367ITN3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003632">
        <property type="protein sequence ID" value="RCH80999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITN3"/>
    <dbReference type="STRING" id="86630.A0A367ITN3"/>
    <dbReference type="OrthoDB" id="2158148at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="227" mass="26977" checksum="482AD5FAC23980C8" modified="2018-11-07" version="1">MYLHRIANEYPLVRIINALKWLISDWRLESISTLVRYVTVDWCDEVGDLRRAHLLRHLTNSWATQYTTTLITMVLSSAPYASATHLQRERFLRAFTKDWDFSKLSEFFMYLQSPANIDYKVKCVMLQEAARRERETLGAKLYHRKKQTEEEEEKLGEGETEIDDGNRRHHRRTSSNDVNDIKRLRLSTPDLDHVEGLQEANVDSSSTNNPHLHLRSYQQQQWQLFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUX5</accession>
    <name>A0A367IUX5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase (putative) YhgA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003504">
        <property type="protein sequence ID" value="RCH81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUX5"/>
    <dbReference type="OrthoDB" id="2272947at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31888" checksum="A0B0D79EB5803804" modified="2018-11-07" version="1" fragment="single">FKLSKQHKPGADRLSRLLALQPEFINSVTAALINSPSGTHISAPTIFLDKEYDVIYVSKIANSFPPIILEFQAKVNLDFIHRAFSYCMEVYKQYSILPIVLVFYIKEMDQFLLVEKFKTTQQWPYMLETECSFVSRHFYLLTKDSIMDLVNADEPLPPLAAALHMEAATQDGTQESSRLDTLKRVCVDAHDQFEKIVKSPRLDPGQAIRYALAGMEYTSQTARKIDDLLSNEDDCVTPMEEPDSDDLVCNDPARKPESDFDKQVILDFVDKKEFKGRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW72</accession>
    <name>A0A367IW72_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosylmethionine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_005747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003213">
        <property type="protein sequence ID" value="RCH81950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW72"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="88"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="179"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH81950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30377" checksum="852946E858D5EBA7" modified="2018-11-07" version="1">MSNNNQQGTLKQAMLAGACAGTAVDTVLFPLDTIKTRLQSQHGFIASGGFRGIYSGLLSAVIGSAPNASLFFVTYEATKRVLSTTLDHAPLTHMIAASCGETIACTVRVPTEVIKQRMQTKQFTSTSAAVSHVLRTEGILGMYRGFLSTVAREIPFTCIQFPLYEYFKQSYAVMKGRRTEPYEAAFMGSVAGGIAAGVTTPLDVCKTRIMLSHKNQASGKHYDGIISTMKRIVAEEGPRALFSGVGPRIMWISIGGSIFLGVYEKALKTFVQLHVLDERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXX7</accession>
    <name>A0A367IXX7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003007">
        <property type="protein sequence ID" value="RCH82459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXX7"/>
    <dbReference type="STRING" id="86630.A0A367IXX7"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="583" mass="67394" checksum="7A16E77CAEED50C4" modified="2018-11-07" version="1" fragment="single">LCAKKSISSSTMRYLRNTTNFFYKQFEAMSSRLETDLHVESCPFSGTIRCADGTEIRSDFFRVRAKLHQRAWLLQLIALELHATTHMKQKANINRLLELLYGRSPDTDMSIHEQQETPLFSQGSFHTLQQPLVKMLEFVSSLEFVWQDDLVKDGPIQEINYFRQFVPEDFYMTNEDGIKLYDIRSIYGYLRLVQIAEYANSPDTELIEKEMGDILAACMSLNRSKEITHARRHCMKAWKQVIHISLLECFDLLNTQEREKTIYELLAMVLSKILNAHNYDSDMVKSMSEVALALINRLRKEKDSRTIAQLPIDKLRHTFNGIIECICQQNIKMTVRGDLYTALTNLLLYINRYKRDESYIEFEKYMVNVVISYKASLLDTLCRDAIDGLDIWKTTAFIAIDALNTMTLRAGSDVVQSYLLNKNFLQYTIDMLKYDDSALVHILESIDASQLPLYIFEARMSILLRLAMNPDGAELLFDNQIFEVLCQSLFMRVEQQNPASVQANISTSGELLDRYQRVMLPTLKLIVAILSTFGKKNAKVISKVQVWLKKQDTAINNILKTEGQQNVSQEAVKLIRIIQNYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYA0</accession>
    <name>A0A367IYA0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_000669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002936">
        <property type="protein sequence ID" value="RCH82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYA0"/>
    <dbReference type="STRING" id="86630.A0A367IYA0"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="33604" checksum="B504F52980FA15F6" modified="2018-11-07" version="1" fragment="single">MAYSPPRPGSKIIIVGGGCFGLSTAYALSLKQQYDIYVFDRQPIPCPDAASTDINKIVRLDYADNTLYMHLAIESLPLWHQWNKERAEKNQCPVFHQSGVLLFGQEDFSDFEKKSIKAIQEAGYGHFIDVYSSPEEIVRAFPQFQQAVDNGFKKAYLNKQGGMYLAAHFRHCVTHLLGWCNSAEAVKHVYQKCLDNGVHFVVGEKRGHFAKLYCDPKNPTTVLGIQTVDEKIHHGDLVLLTTGSWTAGLVDMHHQVIASGQQVVHFTPPPQLKETWEKMPVWCGDLSNTGYYGFPVNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYH1</accession>
    <name>A0A367IYH1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002986">
        <property type="protein sequence ID" value="RCH82521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYH1"/>
    <dbReference type="STRING" id="86630.A0A367IYH1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH82521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="8230" checksum="1436AF920E9EAAB7" modified="2018-11-07" version="1">MDTCTNCSRRVYVIEKVEANGRIYHKSCFKCKDEGCRLTIANFHYYGGDLFCPKHVPKFNAIVSPRTPKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYX4</accession>
    <name>A0A367IYX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002860">
        <property type="protein sequence ID" value="RCH82882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYX4"/>
    <dbReference type="STRING" id="86630.A0A367IYX4"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="47142" checksum="77DE0CE2500F645A" modified="2018-11-07" version="1">MPAFPILSVSRKPVLLVIFVSAFFFLYQIANHPKVSKQLQPVAYYTDYDEKACLPQKQFINNPPAKKARAAMVILVRNKEQADIAQTIVNFEDRFNKNFKYPYVFLNEEPFTDEFKEAVKKAAPNADMRFGLVPENHWSYPVWVNKTLAAEKRAEMGRKGVYYGDLESYHHMCRYQSGFFFDHPLLDEFDWYWRVEPGVKYYCDITYDPFLFMEKYKKKYGFVVTLTELPETIPTLWQHVLDYAKTRRIDTSEKSHLLFPYFVNKDTGDFNLCHFWSNFEIASLDLWRSPQYRDFFNYLDKTGNFFYERWGDAPVHSLAAGLFLETSEVHYFEDFGYQHDLYRHCPSPSKDIGCRCECPTGTTDESIDHDQHYDTCLPKWIQHEKEARKKKSWDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ49</accession>
    <name>A0A367IZ49_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002831">
        <property type="protein sequence ID" value="RCH82954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ49"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="52" mass="6120" checksum="6A960861AE5FE3B0" modified="2018-11-07" version="1" fragment="single">MEQEQPQGYNVFVPDFDKDLVLASTTDERYNESIRDCLEKDLDLIQQQVNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ84</accession>
    <name>A0A367IZ84_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002811">
        <property type="protein sequence ID" value="RCH83005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ84"/>
    <dbReference type="STRING" id="86630.A0A367IZ84"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42133" checksum="2AEFD6454A685079" modified="2018-11-07" version="1" fragment="single">MEAKVTRHTSTNLEEINEKIAKLLKDPAEAIDNVPIDVDSMSLTELKAFAERGGLGACVSKVDVLANTPDDLMYLQGERIVVLKHIEDDIYMGYCEGVIGNFNAENVHFVELDPRVLESLDADLDFTDHSQYRYSASSHGTEDIEMIRNRQEHFIRDSVHSYSSTSDRYTSPVPSSRHHWVSKPSFESIGTASTTSSNNLKASHISYQSYTYSEENTNHEDPFDTSALNVDYSDEENSELYSPAPSTPNVTVPKTSKQTASDAVSKPASSSPLENIRVDEYGFITKPDRPSFRTNMTAKAMKEYRENELKWLTIMNKLDAGTVKKDVKMKKLVRGGIPASVRAKVWQFLAGSDDYRKPHQFQNLLDRPRIAIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0K7</accession>
    <name>A0A367J0K7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002652">
        <property type="protein sequence ID" value="RCH83466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0K7"/>
    <dbReference type="OrthoDB" id="10326596at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="214" mass="23450" checksum="0020FB86D8EF3ACF" modified="2018-11-07" version="1">MADAAHQTRSVEISSSLHTYDERNDRFTTATTTTMNIGERGTISTMMSVSENEDNETLTTLSNATDEAIVNELTASIVLSSTSTSPSISSQLSVPTQFTEIDILPPTTDDCLIFNDFDISARFHSFKQDVNSSIQQGIAITVEEHVQHLLALSSILLLKPARTHKELHKHIDLSTCDALILPITRKARVDFNLCLSEASLVKVATRARSISTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0R9</accession>
    <name>A0A367J0R9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002705">
        <property type="protein sequence ID" value="RCH83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0R9"/>
    <dbReference type="STRING" id="86630.A0A367J0R9"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="232" mass="26786" checksum="540FE78992197461" modified="2018-11-07" version="1">MAKRNEKDIDNDLAERFNKVFATQAIAARNDYQIPSNLDEKDITQEIEKMLYETDDEEDAIDDYIYGVLTQSEPQQGRIQQKMKQIEDILLGPDNPIESDESDALIKKAIEENRLDEKYQQFTAKRDTELQERLKNIQNYVPSSSSTSCSAVIGDKPVGSVPKAISTKDLYDETDDWCCVCNEDAIIECEGCEDDNKYCTECFFQTHRSEFADYEATKHKSKKYQKRVRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J133</accession>
    <name>A0A367J133_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coiled-coil domain-containing protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CCDC47_2</name>
        <name evidence="8" type="ORF">CU097_007117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002604">
        <property type="protein sequence ID" value="RCH83620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J133"/>
    <dbReference type="STRING" id="86630.A0A367J133"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562036" evidence="7">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="41430" checksum="1795649710917872" modified="2018-11-07" version="1">MSNLLIVTLTTLLSYVVAEGENTVEKKPMEVPSDSVMIRPFTIHDFVMEIILVITFLLYAAAWYQGKSANLKKAKTWLGGQLEYLQSQFALVGDGKSVLMKDGPADYLLYVSGRRHVQFGHWWLKLKPRNDMLTYFTTQVLSMAGQTKPVNDRVTLSMVLDKALPEKFVFAVIKKSESAELSKKRFDLNRVAKLGSSKAIPESLTVYTESQKLADLILSTTNVGKLISDASDRLEYLVISSLPADVPYRYENDEALMISLSFSMSNSNTLDPLVELACELPDVLNELKLTSDIRNQVNKNRESLRKEYAKRLAADKAEEAARKKAEAKRAEEERIKKMSPAEQRKWEEKERLRQLKKQQKKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1C7</accession>
    <name>A0A367J1C7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase I enhancer binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">REB1_1</name>
        <name evidence="6" type="ORF">CU097_001371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002632">
        <property type="protein sequence ID" value="RCH83521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1C7"/>
    <dbReference type="STRING" id="86630.A0A367J1C7"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="374"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="453" mass="52417" checksum="60D1C011A55D57A2" modified="2018-11-07" version="1" fragment="single">MSIQEKKKKDKSKKKDKKHKKDKKKEKKHKKNKVALKESNKNAEIKESKSDMTIDQVSTKDIFVNQTKKKTTKQYQSASDSDDTDKEQSTQRPSVSKADQKQYQSASDSDDTDKEQSTQRPSVLKTDQKQYQSASDSDDTDQEQSTQRQSVSKTDQKQHPSASDSDETDQDQQPLSIIERKRKRSSSNYRTREIIEDSDESDFSSSDDSEPNVDQFALGNQKKRKLKSNRICNRRTLEYNKDASAAENFKGKASSAFVPTVHQDFFISDSDSDTDSNDDYNSDSFPEWQRSFKNRPANASHWPRARRFGYSDNLKLEKRIKKICRRENISFQQVQEIFASDRPSAHLKFFQKIARPFPNVSLKSLAMHCRDAYHPKRDNTPWTGEEVKKLNELVKVYGANPKKLSEHLNRTPLDISRYMNRNRTNDISKVSRGRWTKEEDELLAKAVAKQLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2L7</accession>
    <name>A0A367J2L7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002443">
        <property type="protein sequence ID" value="RCH84166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2L7"/>
    <dbReference type="STRING" id="86630.A0A367J2L7"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="17155" checksum="E06D12583530F135" modified="2018-11-07" version="1">MQSLFDLKKEEDLYSILNCVDSSTSEQIRTEYKRLALQHHPDKNSNSAQFDKIKAAYDILGDPAKRALYDRWKASGLIIPFSQFAQLGTHAQTVHWQSLPSQLTITDHDNTSHVDMTSIRTPSTNSQRVQVESTSFWKKKDYIIQDRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2Q2</accession>
    <name>A0A367J2Q2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002489">
        <property type="protein sequence ID" value="RCH84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2Q2"/>
    <dbReference type="STRING" id="86630.A0A367J2Q2"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="86" mass="9219" checksum="346797F6F75314E6" modified="2018-11-07" version="1">MKTFVGPGAATCCSLLSFCGIIFLVLLGTAFKAKVEVLTEFTSDPDNPNATAEACFTAAIVYACFLGFCGCQALVHKYNSRRQIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3U8</accession>
    <name>A0A367J3U8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002324">
        <property type="protein sequence ID" value="RCH84595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3U8"/>
    <dbReference type="STRING" id="86630.A0A367J3U8"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="179" mass="20891" checksum="9EFDDA54B08A8E90" modified="2018-11-07" version="1" fragment="single">TKEFGWKIYKKIGADISIQRMYRTVQFFVLALKIDIFIEFLVSVFYLIQFALKQGFHTWHLFLFIVITALMLPMLYFGRYAVASENPYQMMIFVFFQVCIVIQLVLIGIEAMQPGDYWYIWICFVILGGILAIVSAVLGLVCMTHFGKGLKPYIQRGENKEKVADNTQRNDQSWTIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J550</accession>
    <name>A0A367J550_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ssk1 response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SSK1_2</name>
        <name evidence="6" type="ORF">CU097_006841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002192">
        <property type="protein sequence ID" value="RCH85067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J550"/>
    <dbReference type="STRING" id="86630.A0A367J550"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="666"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="903"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="906"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="968" mass="106995" checksum="BAFB6002F58AFF7B" modified="2018-11-07" version="1" fragment="single">IQDVALMVITTLEQFSPTAILFNTHELLSACSLAIPTASVFAINTTIRQVCHVSSHLHLLSRLVWQAWPRTNSNLIDNTLPELVTNEFDIGELLQNIGDAMAGVAAKLDVEFVIYHCENNLHHTMVIGDEGAIRHALINHLRNILECCTPGACIEVGLNVSNITDSDNLNITFQITHTASPAIRNSSAALLPNANLTAQLLSYIHATTTVETHKNQTKFEFAFELESGREENRKLFISKETILLKNHYANIKFSNEPSLKELTKFIGNLKGLKIVLHAREKSSFAKHLTGCLASWNTDISHVPVVQRPQFQQHDDTGSETDVSTTSSTASVMPPRSNTSAATTPPVPSPAIEEEHIHSIPPSFILIDDDVLTLEGKLNEFRAQPPASANVLHVKRHHQHKKSNLYQNFFHQGTTAIIHFTSLSNYKAVRDTIQCFTFLPNRDPFSMPRVVVVPKPAGPRRFLTALHTAWNNAVVEPHFSAIATSPSSPVPPIVSLLVQRELAANSPNSNSAVTSPSQENNNRSSPGAANDASSTTTRRRPLSGIFSPPSDNNSHYFAAHHQQQQQTASSPRRKSNTDQPMDYLTAKPTGSPNNPNLSPREIVTNVAEDMCDQKANSPNASPAVQEQKDDEVKEKKMSRAMSNFKLHKKKKKDKRTPFGNVVSPPINVLIVEDNIINQAILSVWMKKHQIKFSVASNGLEAVDKWKSGKFHLILMDIQLPVMNGIEATKTIRSIEKEQKIGVLPMSSSFLRQQQAVAAAAANTIMNEQQEEDLPPMLSEEDKRVTPSIFRSPVIIVALTASSLESDRHAALAAGCNDFLTKPVSLEWLEKKIIEWGCMQALIDFEGWRRWKKTAEPKKPSTPKVTTPTATEEMEAEKKRIEEISKSPNRTGIMLPGVGNLVKSRRLSSVDRHTLKASKSDSDTQSANQVQLRPSSSASTASSRSKKDCDEEDSNSLKKAIRSKGQQMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J581</accession>
    <name>A0A367J581_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_000328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01002244">
        <property type="protein sequence ID" value="RCH84871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J581"/>
    <dbReference type="STRING" id="86630.A0A367J581"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016867554" description="alpha-1,2-Mannosidase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH84871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="260" mass="29348" checksum="6D6392A2F5BB34FC" modified="2018-11-07" version="1" fragment="single">MYPKRISQKLPFIAFACLQLVAGLPTNTDPRAEMVKNAFKHAWKGYTDFAYGHDELQTVSNKTSDSRNGWGASIFDGLDTMIIMGLEEEYNRALEHIKKVNWTLSDSPSKTFETNIRYLGGLLAAYDLKQEPIFLEKAVEIADKVIMPAFDTPNRMPAAFVNVTSGAPVDGNMITLAEFGSLQLELVRLSQLTGNEQYQITGNHVLEMISQVPSKVPGLYPMIWDLDSFTPRSCSDSYYEYLLKTHILMEGKETLQLDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5G1</accession>
    <name>A0A367J5G1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_000679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002174">
        <property type="protein sequence ID" value="RCH85135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5G1"/>
    <dbReference type="STRING" id="86630.A0A367J5G1"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH85135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="462" mass="53685" checksum="B71A1CB4AAEC0A5A" modified="2018-11-07" version="1" fragment="single">MSIYNMSKYDKSRSRTASPRPRIVGGPMRPMPNAQQRMMAQQQPQQPQQQFQQQFQQQFIPPQYEEFQLYSSSKAGQHHLMDFKTNKKVDFKSFAPPVKLHRKEPDRIPYRQYIQQKNNEQQQQQQGQQQQQLGQQQPSHGPKTGADTSLIAPMGGATRNKQMLFKKRTKQIYLAKEDTRELKEQEQRPWILEDIEGQNNFTGTLEGGQRSDYVFFVLTNDGFKVVPVDRWYKFQPKRNVKTLTPEEVEEAFKKRNRQPDNQRWAMLSRREKENPESPIPRQKFKVVDNGERKGAGSDDDVPTKRDSDIDDLDFDEDFQDDEEDGAEHEAEDEEVKDSKERFKKEIKGFTINGGDEDEVDTFESTSKLSSEGKQLRKLVRDLEKNRAYESDEDEDPYASTMTNSSSKLFMPKKPMTKVKKESVSRPVGRPDSPSLFMNKKKEGSPHPTSPTHKPTSPPHHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J622</accession>
    <name>A0A367J622_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002107">
        <property type="protein sequence ID" value="RCH85404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J622"/>
    <dbReference type="OrthoDB" id="2286412at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="190" mass="21491" checksum="DB7DD82D8DFFC475" modified="2018-11-07" version="1">MSSVVSSIEDYLKNCSSRASLAQFVVSHKETTKSFIQQFDNKIQAKNNLVNKYTIAFKNVLPARKRITGKAVYLGIPFAEARLERNIQIQMYRALEVDVSVAKRAATKNLTTNTNTSSPFDERNLNTSDEIMGELKHVTGSTPDMLEYLQSVDHNCHSVIGVCTKVLIVLFHNVDPNFRFIYQIQLDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J624</accession>
    <name>A0A367J624_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002117">
        <property type="protein sequence ID" value="RCH85366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J624"/>
    <dbReference type="STRING" id="86630.A0A367J624"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="398" mass="46145" checksum="B4B0C2572119818F" modified="2018-11-07" version="1">MKRNLTGIAKKLAGPTLLCYTVRFAHLYYSVYLLILLAIVAYLYAHPSHHSLETCRQMSISKRKSLQKSEERFASLKINEFFLNPFDEWKEIPFYKTLLLWSRRWKGNGIPSNEIELDRSLPCKKPCLTHIFKQHDKITFTWFGQSTCLVTIGELTILTDPVFSKRSINDYFGPKRLRPIPCRLEEFIDKVDIVLVSHDHFDHLDENAVRKLGNTVTWYIPLGLGRWFSKRGITRFVELDWWQKVDHQGTTIVCVPAMHWSGSRTPFEKNNTLWCSFVIKSTRHSFFFCGDTGYSPELFQAIGNMYAPFTLAAIPIGSYLPMELMKHLHMGPTDAIQAHRDLGFPRLSIGIHWGTFMMSDENYLAPKKVLETSWQSMKQEVEKESEFITTAFGETVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J628</accession>
    <name>A0A367J628_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MNL1</name>
        <name evidence="9" type="ORF">CU097_003711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01002111">
        <property type="protein sequence ID" value="RCH85388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J628"/>
    <dbReference type="STRING" id="86630.A0A367J628"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="665"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH85388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="779" mass="89098" checksum="2B83CFA36559D45B" modified="2018-11-07" version="1">MFEHGWNSYIEHAFPDDELNPFECRGRGSDKANPDNINVNDVLGDYSLTLVDTLDTLAVIGTRKQFEEAVKQVIKTVSFHQNNKVQVFELNIRALGGLLSAHMLITDPKLDYSIEGYKDELLHLAVDLANRLMPAFNSTKTGIPYPRVNLQKGVPPTETTETCTAGAGSLILEFGLLSRLTGDPAYEEVAKRALKSVWNRRSHLNLLGNVIDIQTGNWIHTASSTGAGIDSVFEYMLKAYILFGEDEYLDMFEEAYRALMIYVRDSSGYIYRNVHMSTGSLMSYWIDSLSAFFPGLQVLYGDIHAAIKNHLVFYNIWRRYHALPERFDFYQKRVNLPYYPLRPEFIESTYYLYQATKDPFYLDVGEMVIQDLNNRTRLACGFASIGDVESGKLEDRMESFMLSETLKYLYLLFDTEHPFNKRDSNAVFTTEGHWISLPQRYLRRSKTTKQVKNLISIQSNPFGTCPRYNPLHYKTIYTPGHLDMTSIPYQPQADYAAHIAGYAHSSLPPLSIKGYCDSPWTLARNFNLSFGSTRRPNSVIEILGDYLIKSLSGLKIEFVSAKRNDGFFIKGVHSSSIISNEQIYIDLDTLLPFLQDNRDLIQVQVKQPGLTRYRDYTQLDYDVILRTVNDYECMEMIGLTSEFGAQTIQLPDTPIHVFGDQSKFFGCEPYSRQDANLVKDKVLLISRGKCEFYKKALFAQEAGAVGVIFLSNEPHLFRPSLLKNDIRIPCVLLSQTDSLVLIQQQTKRMYLTMDTLFLTPDSQFRMLLKRERVHNAILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6A3</accession>
    <name>A0A367J6A3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Insulinase (Peptidase M16)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IDE1_2</name>
        <name evidence="11" type="ORF">CU097_007796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002102">
        <property type="protein sequence ID" value="RCH85425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6A3"/>
    <dbReference type="STRING" id="86630.A0A367J6A3"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="50"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="441"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH85425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="748" mass="86177" checksum="953DE3C90111D4BF" modified="2018-11-07" version="1">MRISIDLTEEGLNRYKDVVVIVFKYIDLLKKKGIQSRIFEEVQSLASLAFRFKEKQRPSQYTSRVAGLMQHGYPSQYILSGPSLIRHYDPDLIKENLNWLRPDNFRILLACQNPPGGVQFTQKERWYQSEYTVIDFDNDFINSLENLEPENALVLPGKNAFIPTNFEMNKKEVETPATKPDIVENSPLLRLWHKKDDTFWVPRANVWILLRSPLAYATPSNCVKTRLYADLLKDSLNEYAYDAEVAGLAYTIENQLEGMLLAIGGYNDKLPVLLEKVVQKMRNFEVDIERFKLLKEQLLRIYKNFALEPPYQHALYYHSYLTQDTMWTNAEKLKELEMITAEDVQSFYPSLISRLHIEALVHGNFSREDAQKMLHDTIDILKPKALQPSELIGNRSLTLPHGSKWVYQRDVEDPNNVNSGIEYVIQVGNITETSLRAKLTLLAQIAQEPCFDQLRTKEQLGYLVFSGVRKQVGSMGLRFILQSERDTIYLENRIEDFLDKLRALVEKMTPEEYDAQVQSVITKKLEKDKNLAQEGSKYWSHIHSGFYEFDQAEKDIKELKEIKKEDLLAFMSEYIDPCSSKFRKLSVHIQSQKAQTAQPKKFKVNIESLHTCLVSQGVTRLSIEDIRSAVEKGDAGEASIEANLRELLTDETKAEEEEIEALMAKLVTAMRETESVDGSLVNVKSQKTARRLSMVSRQLNNNDSDQDQKERDHTKLPEGNKIVTNVREFKNSLELSPAPCPLIDFQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6E1</accession>
    <name>A0A367J6E1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002076">
        <property type="protein sequence ID" value="RCH85524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6E1"/>
    <dbReference type="STRING" id="86630.A0A367J6E1"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8746" checksum="731FF971850878D8" modified="2018-11-07" version="1">MSQSEQSKWHEKLVGKYIVEDDAPTTLSEGEYVRVKDLPKPNRVLFANSIMTMDYRTDRLNVHVDDNMKVKGVSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6J0</accession>
    <name>A0A367J6J0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002071">
        <property type="protein sequence ID" value="RCH85543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6J0"/>
    <dbReference type="OrthoDB" id="2242533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="14948" checksum="0B4261ED14CAAF40" modified="2018-11-07" version="1">MDKVCDDKRIKTSKSVKAAWEQVVHLYENRNEMEARSFIAKGIDQHRDLEVIIGFKTIQQLLIAFRRYHQLLNPLHIKPPPEYDIAFKLWLPIFDCIFVEDPLLATRIAENRKRVHGYSKAVDICTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6N8</accession>
    <name>A0A367J6N8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002055">
        <property type="protein sequence ID" value="RCH85607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6N8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8565" checksum="496D937396994381" modified="2018-11-07" version="1">MIQVADCVLKLPKDHTAVFHKVMHTSCTVCISRGQNPNIRVELEEMLSKHNNVKIVQFDYRACDMSSGTSAAKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7J3</accession>
    <name>A0A367J7J3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of volume decrease after cellular swelling-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001988">
        <property type="protein sequence ID" value="RCH85898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7J3"/>
    <dbReference type="STRING" id="86630.A0A367J7J3"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21978" checksum="6F6512E09A908173" modified="2018-11-07" version="1">MTVTLLSQAPDESTLKARHIQRDTALLVSPPLTGQEGPLFGDMFVCEEQFYFYSEASKSGIAVEYPDIIIHAISRQDGQPNIYCQLDSGIFFPNQQLPEDDYDRQETVTELRLIPRDSGALEGIYLAMSECAALHPDKEFMEEQEESDQEFYAPSDEAELNEVQQAALRHLESVFEQPPKMNGHQFDDPVDESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7P1</accession>
    <name>A0A367J7P1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002001">
        <property type="protein sequence ID" value="RCH85849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7P1"/>
    <dbReference type="STRING" id="86630.A0A367J7P1"/>
    <dbReference type="OrthoDB" id="2279208at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="239" mass="27862" checksum="9B756473D6976C70" modified="2018-11-07" version="1" fragment="single">AVVKRYPDGRQEIIVPQTLTPEQQHYEFPPRSKLLKKLAVSERLQPSQERKQTLPDQDALQEWFAKKEPTDKDRAVMDWMSDVERHSRQIQKVAKVQQVRPSPTPSIGSNKIQFKSDAGKRWASSIQNTSLQPPDDTCKKHYVPRRLLQKKHVPQERAVTETASRIQSMWKEYQNKHPQHYIESKIGMTAMASTGERTPMAGMVQLVHMLHESLKIQQQRSADRLEKLEKKRSSRLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8Q1</accession>
    <name>A0A367J8Q1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001888">
        <property type="protein sequence ID" value="RCH86344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8Q1"/>
    <dbReference type="OrthoDB" id="2247269at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="68" mass="7955" checksum="AFF4EDF90E463C7C" modified="2018-11-07" version="1" fragment="single">MPKDESHYVSFAILLAAMPSLKRQVFLNYSRLNAVLEAKCRHQIEMMAFETENENELLFLSESTEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9D7</accession>
    <name>A0A367J9D7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001884">
        <property type="protein sequence ID" value="RCH86361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9D7"/>
    <dbReference type="STRING" id="86630.A0A367J9D7"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="61" mass="6846" checksum="6BC8CE7C5D83603A" modified="2018-11-07" version="1" fragment="single">MCDLSDPRIVEAYTSIVEEGTADWLLLGYHDTRDVISLYFSGSGGLAEFRNHLSDEVLYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA05</accession>
    <name>A0A367JA05_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001798">
        <property type="protein sequence ID" value="RCH86768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA05"/>
    <dbReference type="OrthoDB" id="2553298at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="8269" checksum="735D5A2969456C87" modified="2018-11-07" version="1">MPQKQLTPHQISKGLSYVHKEAPFLAKLKDRTQEKEEAKKKFMNYEDGQDDDDYDELEGAQVVELDSNGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAG0</accession>
    <name>A0A367JAG0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PHB1_2</name>
        <name evidence="5" type="ORF">CU097_004908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001807">
        <property type="protein sequence ID" value="RCH86721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAG0"/>
    <dbReference type="STRING" id="86630.A0A367JAG0"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712796" description="Prohibitin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="274" mass="30348" checksum="C1F1339B1027F01E" modified="2018-11-07" version="1">MSAVLGTVAKWAIPVGLAVGAAQSAMYDVQGGYRAVIFDRIQGVKPNAIGEGTHFLIPWLQRAVLFDVRTRPRNISTTTGSKDMQMVSLTLRVLHRPEIKNLPLIYQNLGQDYDERVLPSIGNEVLKAIVAQFDASELITQREVVSARIREELYKRAKDFNLALEDVSITHMTFGREFTNAVEQKQIAQQEAERAKFIVERAEQEKQAAIIRAEGDSEAAEMISSALAKAGDGFIAFRRIEASKEIAQTLSQTQNVTYLPSNKNGNNMLLGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB92</accession>
    <name>A0A367JB92_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001707">
        <property type="protein sequence ID" value="RCH87198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB92"/>
    <dbReference type="STRING" id="86630.A0A367JB92"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH87198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="914" mass="105992" checksum="F09007B9864B26A9" modified="2018-11-07" version="1">MNRLDLPEYAEDAAILRFYHLDSLEPEMWMDDEDNADKELNNNKFQHPEEEQQQLGTAVRPSETDIELQALDDSDPLGVYSSIFPDEKSRNTNLTQLKEKATVMITNKKFQPRHFLLQVHRNTSYNELVQGEERLRRDVDQRAEALKSLVHQNFDRFVSAKNTIDHVYDEMKSKQLNQQQDYGTIDIQKALEAANNRAEQIYGPVVERRQRVEKVKGTLYMLQRYRFLFNLPNSLMESIKQTKYEAAIRDYKKGKYLYQVLKGDLDSTDEAEQKDNRLTDIHLKVFDKVWAEAVKIVSELQNVLLRQLADPWRSMEEQEKTINFLFDLDTTEDPAWFYLDSQHQWITGLMKETFDTAIQKINRVRAEDGSEDSSIKRSLTLKKAISQIPILKEMGSEEEKLDIEQKVWRATSDLVKSLSSLLLRCLPDFWRLSKAFIEGKFANKTSTTTISSNRKRRQGMDMNKVEQCQRMTRDIIDQYVSLLSDYFSLDQKQLEMQKVKDGSERCIMPSFVPVNANSVYTSEYLTLIIGDLATCVNDINNINLAGEAFSGLTNLMEKARSKFIDIVCKCWERDAVSFYMLEEWILDPQNSQITTLLKRYYDFHKFCARSVHKIASLTAMTDEADEQPKVPISPVHIEKIRESFLTSTYAFLDGLVQLAFTDYTPLNDKEELILTKKRGHIDVHSTDIRILLTVSNLEHMRGNVIRKLVELFEVAFNVQMKEDYSTLIDVVDKLDQILFGDYIKRKSQTIRDIIRQGILHSGIDWSSIPKPQEVHPFVYEALMTLVMVHSQISAVTKQLVGRALSRLLELMASDCLESFKQVERFGMGGMLQATLEIEFMHQTLSQYVTPTASDTLQLIYQTIEQAYDPQQQSSSNLQAELSHVKELLVFSRKSTVVQFLCFKQNKDRRKTVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCI8</accession>
    <name>A0A367JCI8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_005494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001625">
        <property type="protein sequence ID" value="RCH87595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCI8"/>
    <dbReference type="STRING" id="86630.A0A367JCI8"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH87595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="260" mass="30239" checksum="BC65479B5466AAC8" modified="2018-11-07" version="1">MSSSQEMQNMAVHQTIHENVAVEKYFVTRQLPSLETISNPIEDEHVRNKLSTMSFKEHHPLLKRIIDPTEQQQQRRHSIANIIEPEYKYSAPYPIPYSAPSTPPYHQHQSSPHYFYAKDPMRRNSMATMATGRRDSSNRITALILSEDENNISRRASTSSISSSSSSLQHEGTPKGRYARSPELRASHKLAERKRRQEMKELFDELRKALPVDKSLKTSKWEILSKSIDYIGALRHRVYVKENEVAQLKQEIEELKRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDK7</accession>
    <name>A0A367JDK7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001544">
        <property type="protein sequence ID" value="RCH88023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDK7"/>
    <dbReference type="OrthoDB" id="10287164at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="16110" checksum="FD88C4847D04738C" modified="2018-11-07" version="1">MDAKVTKVPKAPSDSKQTAPLPSCSSESQASLSRPETPKVKPINIPGTMNKKRRFSDCLDDDDLQLQKRKVNRPLFIVGSFEEDKPPVPWPPMFETICPDPSLNWEEQEVDVFSDRYTSDLIFYMDDSDDASSCGDELIEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDV1</accession>
    <name>A0A367JDV1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001522">
        <property type="protein sequence ID" value="RCH88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDV1"/>
    <dbReference type="STRING" id="86630.A0A367JDV1"/>
    <dbReference type="OrthoDB" id="2266370at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="620" mass="68947" checksum="E27444507969A717" modified="2018-11-07" version="1" fragment="single">MDAETHFHLEHMSFTAGQLSGLIITNLVASIMSLAGTICVLIVHGILLAYRPKVVNRLSLRLIVLSSIFDGVYSASQIAVDHIDSRQSSCRVLIYILISTDTMACMCLAVIGLNLVMILAMKVSRTKKLEIFYYVIIAVSGVLVAVVPRLVPHIRGPLPDEIVASCWYHYYFEGRMRNLFNWLWYYGWLLFSSLFAAMYAIIAIIFIVRARGNYAGTLDLQSRKHDTAISSLYILRKHGNTTDVFRKIAIRCICYPLVPLISKIWGVSIEIAVAANAHIPYPVFILDRLFSSLLAFMVSCIYFTDPAICTVLGEIMDTIKRRYVHDYYTVLFQPDPESDENDDDYPKIIRIAPVRGEGRGEHARISALIEDIKKKLLDDVGSEVDVGGVFPADDDESINMYAHISHVPSVELQTTKGQRISSPEKLYDIVTVTSKNGRVYLPNNKFTDNASGSFKSFPQRSRAFIIPLLKLNKSDNGSSDHFNGTSGPSYQRNELGAVESLRPFKHPLTARFLHWLLIHVFRVKPVAVNVPTSTIRISDVANRTKSAVTSGASTSKPSENKDSATIDRSRNLSALSSAVSFAPVSGASQDDLLTDSRFATESEIDIQNDTARLPNVSPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDY5</accession>
    <name>A0A367JDY5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001524">
        <property type="protein sequence ID" value="RCH88136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDY5"/>
    <dbReference type="STRING" id="86630.A0A367JDY5"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="303" mass="35135" checksum="41E3F06683654296" modified="2018-11-07" version="1">MQYERNFNEGESIPVLTNKNSNNTFVHKLYNMVIDNQYQHLIAWSYTGSSFIVCNILEFSRDVLPKHFKHNNFSSFVRQLNMYGFHKVNKSPRGHRTLAENQIWEFSHPKFIKDRPDLLDEIKRKSIETTNVNDKKDNTMMTMIQVSQSELMQRMTKLQQTYHQLKKELEETKYNQSRQLHLLKQIIDFIYQRHGIQISLPLELLSSSDNSNQPSTPSIFITSHDFIDSLAPTTPTPTNTHIDNNHNTQIRHRPVLTVQTHGLSPGLEQQQPTSPALSVYHTALNTPVTPNSAQFISDDDIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEE3</accession>
    <name>A0A367JEE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001529">
        <property type="protein sequence ID" value="RCH88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEE3"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="151" mass="17353" checksum="2B98705B1D7CBBD5" modified="2018-11-07" version="1">MNSSLDIPQFVIIHDQTLNAYKHPVIHYVFEQEEFPEVPKDKLIVVELDSTATQLTSVDSYSPDFQVTDCILEQSRLNSQFEKEESNLFNLTIEGVSVPAVQQIPSSQPIHSIDSLKETIFQFKDRNEMVKKIFKQPVSEQQDNSMNISLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEL9</accession>
    <name>A0A367JEL9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001487">
        <property type="protein sequence ID" value="RCH88325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEL9"/>
    <dbReference type="STRING" id="86630.A0A367JEL9"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="287" mass="33251" checksum="D8D59615BF099274" modified="2018-11-07" version="1">MYEKTEKGTQLELFAENFMYLCLGYFFFEMESYAVHAVELLQIFFLNETTRMNPNLNYAQLVRGSQNCTKMGRDEGVVSGRALCRIANMLSYLDNFYLYRPIDQCIKAWFNQYFQWLTGSSVAKQAARAKNNIHTWYIAHVVSTVRFLDPSSAELTRHIVGFFEKTLLEQIDMATGDQPSESKRAQPLHYLAFNMYAILYIAELAKSIELDMYLTKKEILHIAALYMIKVSKANQKIDITEAARCVEIIWKRVCGDDCCKEFIDLCHNCEFAERISGPKNAICKCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFH3</accession>
    <name>A0A367JFH3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001426">
        <property type="protein sequence ID" value="RCH88670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFH3"/>
    <dbReference type="STRING" id="86630.A0A367JFH3"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="326" mass="35689" checksum="0D107A29BDCA51F1" modified="2018-11-07" version="1">MVLVTRITQLLGIKHPIIQGGMQHVGKAELASAVSNSGALGILTALTQPTPEDLRKEIRRCREMTDKPFGVNMTFLPALKLPPYKEYAQVIIEERVKIVETAGNNPGEFIKMFKDADIKTIHKCVAVRHALTAQRLGVDAVSMDGFECAGHPGEDDITGLILLAKSARKLNIPFIASGGIGDGRGLAAALALGAEGVNMGTRFLCTKEAPIHEAIKQKMVEADERSTALVYRPFRNTARIFKNKIAVEVNEIERTKKDLKFEDIAELVSGTRGKQVFVKGDPDLGIWTAGQVLGLIDDIPTCHQLVTRMVDEAEMIISQRLRNMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG65</accession>
    <name>A0A367JG65_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001381">
        <property type="protein sequence ID" value="RCH88924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG65"/>
    <dbReference type="OrthoDB" id="10272932at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="16337" checksum="5431B829B539B205" modified="2018-11-07" version="1">MTVTLQANSLFASDEEEDTRSFADIVEYWKGLSKNAPKNKKALEDFSRNNPTLIQLPKTNTTAPWHIAAAMEMKVNNVVHKSSTKPGVVPVDFTEYLEYHLRMKKEQEQQITVDDVEELFGLADDDAPKRSGSVKRFFKKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHD2</accession>
    <name>A0A367JHD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="16">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SCS7_2</name>
        <name evidence="21" type="ORF">CU097_005642</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16 17">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01001313">
        <property type="protein sequence ID" value="RCH89306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHD2"/>
    <dbReference type="STRING" id="86630.A0A367JHD2"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 18" id="KW-0408">Iron</keyword>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH89306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="43247" checksum="C632174C8F79386B" modified="2018-11-07" version="1">MSKLFTKQEVAKHNSSKSLWVVFNDRVYDITEFAKDHPGGDDFLLQFAGKDITEVMSDKDYHEHSEASFEILQDYVIGRMDNKACTRRLEGHRVSLHRKRVALLEKEIEYKTFKEDNFHPSLTDAHIDVKVNQFLDLNKPLVPQMITMRFTREHYLEQVHKPRYLNRPANFFGHPLLEPFSKTYWWVVPLVWLPYVVYNLHHSLLMNQHNIMTTGSLFLLGIFIWTFLEYALHRFLFHYDDRMPENQFMFLLHFVLHGFHHYLPMDRARLVVPPALLAVLAYPWITLAHMLFPSSAAFAVVAGGMFGYVCYDMTHYYVHHAKVIPFHFKEMKKYHLAHHYKDFEAGYGITSKFWDYVFNTVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHY3</accession>
    <name>A0A367JHY3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_003596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001267">
        <property type="protein sequence ID" value="RCH89558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHY3"/>
    <dbReference type="STRING" id="86630.A0A367JHY3"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="931" mass="106030" checksum="A9E975BF72A3C4DC" modified="2018-11-07" version="1">MAWQPDQQGLRELTYLLREAANPNGRDQGLISQRLQLFNEYPDYNAYLIYILTKATNEDINTRRVAGLQLKNNIKNNFNSIPMFTLNYVKQTCIEALAHPEVVIVKTLSSVVSSIVSRGQVHNWLDVLSFLIHQLNSNNKLAIETALNTLVMICEDTAIELDEEMHGIRPLSFMLPKFIEFISSAEPRWRVQAINATSQFVLLKSPSFVEQFDAILTALYARTTDSDHRVRRELGRILAILWEAFPDKLQPYLYPTIEYMIQATMDQDEEVALGACDFWVQYAQVDRYHDELVPYLTRLVNCLLRLMVYSEKDLLDLSDEPMHTPFIEEDSDQAIRPRYYRPKNPIESPEPVDHPQNYSDSESEFDSDEHHITDDDEHDDDRDEFDDFDDDEFYSQVSLRQSSAAALDVLSVTYKSDIASVLLDQLLHHTLHDSNWLIRESGILALGAAAEGGIEVISRYLHQLIPYLLNSMQDPQPLIRSISCWATSRFSKWLMHQYDTNEQGRQLYFESVLYALLHTLLDTNKRVQESACTAFTILEENASNRLRPYIYSILTHTNKAFTLYRRKNRLILYDVLGTLADSVGHALNNPTYIGLLMPPLITKWNELADNDTDLFPLLECLSNITAALGSGFKPFVEPVLSRCVQLISSTLQQQAYADEYPDKISPPNVEFLIAALDLLSGIVQGLGSNIQPLIANTNPPLLSLLRTCIHDPVSEVLQSTFALIGDIAIACFNLLEPFIPDIMVKLIQVLKSPEYIISVVSVYNNALWAIGEIVMRWKSKTMYYIPALIDVLVPLLKHAHAPPSVHENSMVALGRLGLACPENVAPHLRKFIKPWLKKSLSVREGDEKDSAFRGLCAMIRINVNDAQEELYLLLVSISTWKSPSSLLSKDLHDVVEGFYQMTSQDEWNYTFSSLNKEEQAYIQSILGKNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI30</accession>
    <name>A0A367JI30_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SMC3</name>
        <name evidence="11" type="ORF">CU097_008645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001262">
        <property type="protein sequence ID" value="RCH89590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI30"/>
    <dbReference type="STRING" id="86630.A0A367JI30"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="522"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="172"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="434"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="666"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="783"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="854"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1188" mass="137729" checksum="C564DEFE1412CB14" modified="2018-11-07" version="1">MYIKQIVIQGFKSYKDQNTIEPFSSKHNVIVGRNGSGKSNFFSAIRFVLGDAYQNLSKEERQALLHEGVGTATISAFVEIIFDNSDNRFPTGKEEVILRRSIGLTLDEYSLDRKSVTKTDVLNLLESAGFSRSNPYYIVPQGRVTSLTTAKDEDRLKLLKEVAGTRVYEQKREESNKLMQETNAKRAKIEEVLKYIEERLNELEAEKTELSEYQELDNSRRSIEYTIYAREQTSASHRLEELEEERRRAIRKNEEIEEHHYRGEQRLKELEDQLRDARQTIQLHDQEKKDLLEERNELMKVRARLELLINDLQDSQISDEEYKADIANRLGQLEDSMSQKQSEIDTITPQYTELNETAKQIQQELRTLEAEQEHLRLKQARLTKFASKEERDNWINAQIRDITENLTIRQNQLNMLIEEKKAGEEEMLFKTQAIDELKEKNMARFKLRQELENEEFTLKTERDEATEERKNLWREEAKLDTLIRNYSDEIRKAERTLSSTIDRNTSIGLSAISRIAQQHNIQGVYGPVFELFDCDPRFTTAIDATAGASLFNVIVDTDETATKLLEVMNKEKSGRVTFIPLNRVKPRTAEYPNSTDAIPILNKLQYDARYQHAFEQIFANTIVCPNLEVAASYAKSHRLVAVTLDGSRVDSRGALTGGYVDSRRSRLDAAKRLREVQIQYNEAKERLEQVKQQIVQADQKVTRIVSDLHALELRKKKTEFSDLSQNYESRLRKEEELLKIKLATKTRNIESIQVHGQLLEKQLISYQNELATDLSKLLSSEEREILDRNAVQMEELRRRLTETANQRTELESRINTLKEGLNADSLRKKDLLSKKERVIVKGSLDELNRRRNELKMVTKKLGRLTKRIEDLDTEVDQLLEEDVKITEKIESARDDIKKYARYMSDIEKDLERNFLKRSLLIQKKEECNTNIRDLGVLPDEAFQKYNNLRIEKLLKQLHKINEKLKKYSHVNKKAFEQYGRFTKQRDQLTARKKELDKSGVSISQLIESLDRRKNQAIERTFNDVAANFAQIFETLVPSGRGELIIKSDLQQDVDMDGNNGSVDRFSGVSIKVSFNSKSDEGLIMQQLSGGQKSLVALALIFAIQRCDPAPFYLFDEIDANLDAQYRAAVAEMIHKLSENAQFITTTFRPELVANADKFYGVAFQGKVSRIHAIAKEHALEFVEQEQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKD8</accession>
    <name>A0A367JKD8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001128">
        <property type="protein sequence ID" value="RCH90398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKD8"/>
    <dbReference type="STRING" id="86630.A0A367JKD8"/>
    <dbReference type="OrthoDB" id="10057956at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="365" mass="41101" checksum="360E054D05CF4170" modified="2018-11-07" version="1" fragment="single">MVLTSDPNAVEAFEQIGIYNHIRKACQIKDQDYRVITVSTRLLGHFIKAGGRFEQLEQDYPDLLDLVTTGLRSSEPALRCSCLQACTSFVSCERGQNWLYNNQQAASFIALALLDQSRYVVSEACRLFTILLMIKSPVSDVLDPSAQIKSILSVHTNPSQVTAALEFCWSIINQKDPVTLDYLHRTQLLFPTMPLLCSTHRMIRARVIEILSVLFSWDPDPIQTLGLRNVQKNPIDGVYHVMLDLNTISAENTPYEKQRTSALSENTPCAYSHTAHPSRASFPYLTCKLQVIQLVIDLMNRDEMDVKGMSLALDTFDVFLNDENISGIESSSLDALVSALQLKFLDTEWDVRDAAIQFVGQLFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLM2</accession>
    <name>A0A367JLM2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001061">
        <property type="protein sequence ID" value="RCH90827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLM2"/>
    <dbReference type="STRING" id="86630.A0A367JLM2"/>
    <dbReference type="OrthoDB" id="2217005at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="367" mass="42605" checksum="68B31E518AF6B23D" modified="2018-11-07" version="1">MLSLLPSEILFHIFSFLTYDEVYQLRSVCRKFQWMGEYHIYQQIKALNQTVVLKLDERRNICVKLMANSYDPINRVIEFVPMESEVVSLANTGKRFAYHKLLKVHFSLWNESSHTKLPLEHLEPQDQALFLYHYAYNSSIEKIYELPSWNNSQGNKSTRYLGDKGFILCLSYQQPKINLSPSVSPVIASLPTSFYGYPTSPAATSPIPPAPNLDVKWIRVTLDWVLSGLKPSIPTTQIYEHSFIRLNRLLAKEGCFKYDPLSEPVLDYIIRQQDNSKMELPQTLLNFVHTHTHECHTRLSRLQHMLEGAGVDAQVLWKYTFAKSFVVGNGSLLGEEDVVRRIQDSEEEWRQKKLSFVRKLKVNLVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMD7</accession>
    <name>A0A367JMD7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001021">
        <property type="protein sequence ID" value="RCH91096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMD7"/>
    <dbReference type="STRING" id="86630.A0A367JMD7"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="153" mass="16765" checksum="965C323C5CF4450C" modified="2018-11-07" version="1">MSLRALSSRVIRPYIPVAPTAWTAFRGYATKKYTAAHEWISVENDIGTVGITDHAQKSLGDVVFIETPAVGEKFSAEEQIGTVESVKAVSDIYTPVSGEIVEVNTSLQDEPSLINESAEGEGWLAKIKLSNPQELEALMDEAQYKEHCANDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNY2</accession>
    <name>A0A367JNY2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fanconi anemia group I protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000951">
        <property type="protein sequence ID" value="RCH91569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNY2"/>
    <dbReference type="STRING" id="86630.A0A367JNY2"/>
    <dbReference type="OrthoDB" id="195089at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029313">
        <property type="entry name" value="FANCI_S3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14677">
        <property type="entry name" value="FANCI_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="3">
        <location>
            <begin position="352"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 3" evidence="4">
        <location>
            <begin position="754"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 4" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="142265" checksum="4788C3B63FA47847" modified="2018-11-07" version="1">MDAQLLKLSKQKDKALLKEFLNTVPNDKIADIIKTKLRQSTTNDNDTVLLIRSVLMSSPIEEGQSNLDRRQVVIDCVIEWLSSDNRDIIDKSGLSSSVVNLVLPEIELFPSNTLYETALTIINLGDQSDTIHSKLLDIFTKIWNALSAANEQIELNDVFEKLISANWGNQSIVGVCSAMNEMELSNKQLEQCIDYMIRKLHDVDLEGVPPFIYQLLLVSRKGHKKNVLKGIFDYFKNEKDDISVEGTAMLHISFAVKQDQELGNELVKIMKTNKMNQLDIFSTATLLSVARIHRLQDTIIDLFKSAIISAFKDNERYQQCNWITKYSTSDSTKFSTVLLEIADRSAAGWDQVIQSMTRLSFILIDSVANQGAFFATNHSRNKTSGEPNNANSNLANLAICILARLFKHHDVVRSEILEQITSRIVTRSNSANDFVRLLEIIIRDYPHAIEKHLTTLKDTLDLLSYLPFPIAERLLNAVRPVIKTNQQFRDDLILVLRKSLFAKDIDGREVAVRGFLNVLDDLLAELKQNGTSSQAESVAFEILGLLRRCFSQQSEIRACAYNGLGTLSEDYTTFAGDVFELLSAQFMKSFERNTSVPCPIKLDSCIEPSSSGGFVKTVEPIHILLLNTCRSLQAAASDSSTCSLIIESINRFRSHIKSFIIRLSNAALEDLELDKTTSFDVDTYEGQKNIQYAMLLLPLYEIAIDYEYSMNEMNADTSEVILSLFKKRKDLMDLLSSTSDRSKKTINANKPSSSLKFITKVFKDLFANENNLSEPLRNLKSNIELVHFVVISTGDSLKAAINDPYRHRDEESFNICIELCQLYLQILAQEDSDSIFANNQSFKKGPSVLISLSNHLLSILEIIRNVWPSRFVEFLASVCRLTDSDQNTIIASFIESLRDIVMKFLSGRSPIYKEVSSIMQVISFLTGTFDKSNQDYSQHARQITNWVNELAKDRPIEDTGLTKELISLLIRVSSDAGENHIIHDLCADLHAYAGEIESSFADEDEPMETNIHYQIISNKTFNVIISQVFDYLDHSLDELIWAISKLRLYTANAEEDVPSFEQDICEYFILYMKILSELVRTVLSDTSSENLFKNLAKLYKALQAFVKYKLAFIGDISQTFIKVISISGSDITDRMYKFLTIYGQRQQLADVSHGKKKNKGKRRKEINTKQEARVQRESRMIPQLIYSVEQYERHLIQLSRKSRVDFMQYMKRSTSRDFKIEISLLNEESSSEDEKENTSSASETPSKRARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPA0</accession>
    <name>A0A367JPA0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Epoxide hydrolase, soluble (SEH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SEH1_1</name>
        <name evidence="12" type="ORF">CU097_012179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000932">
        <property type="protein sequence ID" value="RCH91705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPA0"/>
    <dbReference type="STRING" id="86630.A0A367JPA0"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH91705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="479" mass="53485" checksum="513FFC18AFB16615" modified="2018-11-07" version="1">MTSSLTKFDTGHEDLIHDVAYDFYGKRLVTCSSDQKLKVWDFVEREDCSVWELSDSWKAHDSSILKAIWARPEYGQVIASCSFDRQVKIWEEQPTEPRNSQKRWVERFRLVESRGAVLDISFAPTPNSLRLATCSSDGIVRIYEALEPTNLAQWSQMEEFEISSSIPNTPPAGQQPQGQQALPQQQPQGQIQQQLQQTSPYQSQLQQQFQQLQQHQSQLQQQLQQYQPQSQHPQQPVNTKSTSSSGSSIKSHGLSTPGVPDVPTMTSTTAGYIQGISPSSTAGIGEQANAGSIHRPIDADSGYCIDWCPNRSNTPMMVAGLGKEKGARIFKHDGHNRWIPGEILPGHTQEVHDVSWAPNLARSYQLIATASKDQHVRIYKITESTQQAQQQRGSSSNRMPISPAGTPTQQQLNKPLNVELIASFPDHKAEVWRVEWNVTGTILSSSGDDGKLRLWTAGYDGKWRQMATVTANQQVPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPN8</accession>
    <name>A0A367JPN8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000903">
        <property type="protein sequence ID" value="RCH91914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPN8"/>
    <dbReference type="STRING" id="86630.A0A367JPN8"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="851" mass="95367" checksum="5A681A7C6E4D8098" modified="2018-11-07" version="1">MALDEHYICQRAANAIISEIGPFRVSTDALQAINQFLDEFIVLLVGCSLSLDLSEIKSTVFSLLPSTLGKNAIVEAELEVKTFTETESIDYELYERMRKIEKDKFPVDEAIRLLREKCFEYCTLADKEDQLYVQKSIQKRSSQNTIIISPIVAIYVTTVMEHIAEYLLTAVAMSAEHEDTDYVRVKEVYLALVDDIQLGSVFNKMSLKDRMEKRAGLANKLRRVSYLPTPPLTENNNNNNPRKSFHSTTHENETGSVLDFDDDIDLDYFDDNLPKSNLNTTTVSFSSMPRPHSVMSHHSNTSRKSTFHVFKNNRNSFSSFDLPSRAESPVASIYDPDNIPNMNFDDLVKSGGTVKVSLTPNRLRSIEVKDQTKDEEPSLTWERRSMSSPRLSTSSNLSQQTSKKSSNIVLDHKTIDVPRMIPKGPASPLGKKSFTVNDLNRFENPREAPKPPKSASTSSVPASGTTTTTTTTITSVPATIEVAPVTKKPLTPLSAMSANNTSSGKLTPLPKLPTPPSSQTKPVSTTTLASSSSSDSISSSNSSLPSLTPGPVVSSPHDDEHAKQSAVINIQDNTGMIPKSTRSNTINTSGIVMRRSSLSSRKSRESLRRKRSMETQEAKPADNNRPEESPETKQVQFLNTEEEKKKHMPERPSSIVAKRASMIGNIRRRSLHENYATEKYNHEVGQRGSVSVSIKQWDDILKSEEQPLIPPAAQRRSMLRQMRQQQLQEMQQEKEGVISNAVLDKVLKFERASSLDDGAHQRVSSLPRRERFLYLQQDPSAIERKSTSLRPGTRTKGIDVAVQTEPIKKESVEKREEEQGLIDGDEEWFLQDDEWDEQEETAIVEWLLGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRN1</accession>
    <name>A0A367JRN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_008946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000816">
        <property type="protein sequence ID" value="RCH92519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRN1"/>
    <dbReference type="STRING" id="86630.A0A367JRN1"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="73421" checksum="608CB54715D776BF" modified="2018-11-07" version="1">MSSIEDEIPIPSARIEEYESSLFEQEFTEEDVLPFLLQAQDIISKLESRVVELEKDLSTIHCKYEHDKNEWLIGLSQKDQYINHLTSKLSKIEFNSKETIILLSDLNINDEEQVKSAVNLSLQYLRQAQTIKQEEPDDLEEGELERRQAAVVEWSSRTQDIPDNSMSHNEEEPLNLMDGLSSSSTGSAHVTYNTKSIYNHPHVVDEEENQFCMNCKQLLAQLDEQIEQKAYLKRDLGSLAAALSEQEEIRSNIEQDKEALEEDVAGITLQLFSALNQILMEEVTERDHIVQLNREFTNKFTYLLDNWDARDSKLKEMKELLIQLDSAVHQSVSTSATFTRRFSQQNAAPMLTTTTTTTTTTAMSGNSSMQKRLSSHRRTPSFQQQIHNTIQIDGYALSEFQQHLKALTSSNQPIPSTPFVKRVFSEDIEPCLFSQQSNNNWWKSTWFKKKLLDAISKNKCEIQYWNGTYSTTSYMSATTTSSSSVTSSASHVSSGSNNVPMPPKTKCVSCNVLRVCEFRLRLPPASNPWLPIDRFCRDKIIAVCGYYSFMNNLKSLSTSSTLLNTFKQVMYHRRRMTLSRVGSVSLFEDLEDLEDNRRHSRRYRGNRESVVLDHSGSNSDSGSVVSVSDLQGLEGTAASQIVIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRT4</accession>
    <name>A0A367JRT4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000795">
        <property type="protein sequence ID" value="RCH92672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRT4"/>
    <dbReference type="OrthoDB" id="2281772at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="16593" checksum="F953A3F3901615D1" modified="2018-11-07" version="1">MPYIYTQQFYYINSAYKLNEIIQQYQHIIKQDPVARCMIGFVAAQLIRDPTFSLPVESIEDWLKSREPIKDTDNVTSENNSDLNTLMDILKGICYESPSEEPCENEMNTDKITAYHEPSAQTTNKLCRYTSRSPYDFRISQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRW4</accession>
    <name>A0A367JRW4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ethanolamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000799">
        <property type="protein sequence ID" value="RCH92646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRW4"/>
    <dbReference type="STRING" id="86630.A0A367JRW4"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46926" checksum="9E3176D0CCCB5EBB" modified="2018-11-07" version="1">MSTKTRRIQKPFLSTINKILSIRNKISLALRFDDSRSLVRILPLSKQPQPVTNSLAVAHTAIPHCKYTIDLRALKGKELQRAVQKLVTTLFPELVATHTFNLTRVSGAMTNAVYFVNVGSYRMLLRIYGIGCEQILDRDKELSWLSRLSQLSIGPRLLGTFGNGRFEEYLESTTLTRDDLRDPHTSAQIASRLYQLHSIVDTFPPSDNETLEVWQHIDKWYNSLESEIFPILNMDPGWAKEIEQKLNLAELHKDIESCKRILNQLSTPTVFAHNDTQYGNILRTNETNELVVIDFEYAGYNPRGYDIANHFCEWMYNYHGDEPAKMHLEDYPTVEEQMRFLTAYDQQHAVELLEEVELWKMACHLFWGLWGLVQASQSEIEFDYFGYAMQRFDMFKQELAKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRZ6</accession>
    <name>A0A367JRZ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000789">
        <property type="protein sequence ID" value="RCH92717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRZ6"/>
    <dbReference type="STRING" id="86630.A0A367JRZ6"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="195"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="38459" checksum="DC16F08D2C6FF044" modified="2018-11-07" version="1">MPWPLVNISLPDPIVIRPLPLTGLYACMLGTDYLLLKYQHKVPISKQKLRVIISTVHAAVPLAVVSPSSPANIAFALLPWFIASYSAFLPMEKFTVKEWLRSVFETFIDRSPSKGEDVRKLGFAKIIRGTIKLITLTSLVIPAIPSDPEYILKKPWLSKESITTTFLIGLDAYLIFGAADIIAGAIQTVSGQKMEDMFDSPFIATSPRDFWSRRWNRHIRNLLHRQVFRPDTKKEKGFLNSPQGRGLLAFAVSAAFHELIIWSVCRKITLENFCFFLLHGLACAAEVKYFNKQVPQTKLGKIGCMIGQMSFMVLTGRLFLAPFLRHRFLQPLPLTEVSVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSG3</accession>
    <name>A0A367JSG3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000768">
        <property type="protein sequence ID" value="RCH92877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSG3"/>
    <dbReference type="STRING" id="86630.A0A367JSG3"/>
    <dbReference type="OrthoDB" id="4327540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="129" mass="14608" checksum="2731E033EAF0C999" modified="2018-11-07" version="1">MNIVSIKNTGYPSVFSFCVADGWITIETSENFTWFLKKLKDVVDVGLTGSCEEVFPEAKKLLCQVRLRRSIRTKPLTYFGMKNNVFDNKTTGIKEAVTSDRLFEVVKDMYSKAALASSDPKKVMEYLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSY3</accession>
    <name>A0A367JSY3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ANAPC2</name>
        <name evidence="3" type="ORF">CU097_011669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000746">
        <property type="protein sequence ID" value="RCH93064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSY3"/>
    <dbReference type="STRING" id="86630.A0A367JSY3"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="441"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="622" mass="72871" checksum="00D0C50ABDD81906" modified="2018-11-07" version="1">MKKRNDNEQVITLFIQLVNNIYEQIQTGLSTDLSVASNDLKQFVKETTTDIINKSASFHFYNALKLCYQTLLKDIDMMFTLKLSTDVSFAHLFAPNFKYQGKDLERRCRLILDTDLPKITDIFNLGNEFLDNAIRKAMLDDDQLDLTLKDVELWTIEQDNDKHVDIEHLQSNIERIQELCKKLNALSLAPSWTSILKDIVDERLRAKEWEEEYSLSLVNVQLKWLHAIVLPWISHIMSRLNNEDADWYDFLRLKLRAEHVLYESIYQYRIGNILDTILDIPETNNAILDLKITVDKRGYLDDLEKKLLQEIKNRLLQLSVSTTSILEYYAACVQCLRQIDPSCKILLTVTDTIQKYIREYRKDVAQGVVTIIRNPENYDIQLRANDDEPYVFSIDELSNEKTQKEKIPDREHMLEKLEKLKAKSSDMAALLISMCKSVKDFVIAYGDRLGEILLKTKDYDTEEEILRLEIIKMNFPPDMFIRCDIMLKDVAESKRIDKMIHENEAIDNSFRSLIVSRKYWPGNYDSGDGDESEDNDDTHNIMEYWPHQKRIMKDYMAEYGRKKASRRLKFLPSLGTVSIELEFQSGKQELEVQPEAAVIISLYEHEGAYRTCYHFKLSYSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTR0</accession>
    <name>A0A367JTR0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">mRNA decay activator protein zfp36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZFP36_1</name>
        <name evidence="8" type="ORF">CU097_012509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000715">
        <property type="protein sequence ID" value="RCH93296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTR0"/>
    <dbReference type="STRING" id="86630.A0A367JTR0"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="315" mass="36194" checksum="8AF097D0CDE9881E" modified="2018-11-07" version="1">MNDLNTCFSEEEESDSTNSTNSLENSHKRFNKAVLKKREVKLNKKDELDSDNDSLIEYSKNTKKTKNTKKQQSSETEKKQKSLYKTELCRNWEETGQCRYGLKCQYAHGAQDLREIERHPKYKTQKCRTFHKTGACPYGSRCTFRHFSLPGDDAKIKEENDKMGSVTGTSATTTTSTLSTTVFRGTESSKREPMVFPSAFTENLKMFQPNQWYHDASFPFATTATTIPPALGDQSLKRNYSPYVDYEDSLLPSNAESLLPHQLLFDLDSPDVEEQMKHCPIRNHVSQIPSYQHTTINTTNTNDTLCKSFFRPWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU04</accession>
    <name>A0A367JU04_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cyclophilin E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CYP10_2</name>
        <name evidence="11" type="ORF">CU097_011671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000732">
        <property type="protein sequence ID" value="RCH93171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU04"/>
    <dbReference type="STRING" id="86630.A0A367JU04"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="157"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="314" mass="34555" checksum="1C9B0C2378D54D50" modified="2018-11-07" version="1">MPVSITKDNKTTLYISGLDQQVTEQFLYAAFIPFGEIVAVQLALDTEIDTTNVHRGFGFVEYADPEDCQAAMDNMHLSELYGKVIKVQIAKTINVTTTSNRAVWTDEAWLQKYGNLEEAKENEEKEETTKDAVQTNEQDVSSYVPSSTKRGQKCRVYLDIEIGNNFAGRIEIELRGDVVPKTAENFRVLCTGEAGFGYKNSSFHRIIPQFMCQGGDFTKGNGTGGKSIYGGKFEDENFTLKHTGPGTLSMANAGPNTNGSQFFICTEKTAWLDGKHVVFGQVVSGMNVVKQMESCGTANGKPTKRVTIVDCGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU51</accession>
    <name>A0A367JU51_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_012243</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000697">
        <property type="protein sequence ID" value="RCH93446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU51"/>
    <dbReference type="STRING" id="86630.A0A367JU51"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712800" description="Saposin B-type domain-containing protein" evidence="11">
        <location>
            <begin position="18"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="12">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH93446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115750" checksum="27736E036E63ED39" modified="2018-11-07" version="1">MKKWIFIFLFYFTNIIAQQEQQRVINSFDISIQQEKAYELTETLIETDSIATSCSSCISLLQILKKMSLFSEAFLISTLTKICKRTNKVDDDVCEGVIREQAPIIQKVIPTMDISGRDGHLACAAILNSCPYPEVEQWNITFPKPKPELKQEPIKSNGQTFTVLQLSDWHIDLDYQAGAEAKCTKPICCRSAYTDYTNITKRASMWGEYGCDTPLSLIESMLRFIPTAEPDIKFGILTGDIPPHEVWSTLPFIKTKLIQDETYRILHNYFDSPLLVNSMLYPAVGNHESAPTNNFPLRHSTIPFEKKFLDLKWLYRALSKNWQGWLSPLSHPSVEENTGSYSARPIRGLKLISLNTNFCYTLNWWLYQQPVDKDPNGIFAWLINELQDAEDNGERVWIIGHIAPGDNTCFHDYSNYYSQIIERYSHIISAQFFGHTHKDELSIFYKNGKEQTAENAISVGYIGPSITPFLNLNPGFRVYKVDTKTFEIIDSITYSADLSKATDLNNEPNWHVEYSAREAYSSSRARLASSTSPLTPAWWHNVTVDMEDDDTDTFEKYRRFTTKSSPIARECDDECKRKAICNIRAGNSEHRCDYESDVFEPEQKRQKTEIHLCEHTMATNMEIAVSYPASKFEADNTITNPKVLEKYQLAADVVNVVLPLVLERAQVGVSVCDLCQYGDDLIHKYTENMFKSADRGVAVPTCVSLNNYIQYFSPLAENDVYLKVGDVVKVELGVHIDGYIATAAHTTVVTENKQQPVIGKAADVICATYFAYEAACRMLRPGVKASEITRVITEIAAYFRCQPVEGTFSSPMKRFVLRAGKDIENRFLEDLIVSELEKYDFEVEANQVYQMNIVLTTGDGQVKNTDFKPFVYQRDVNKTYQLKMRSARLAYAEVNANHTVFPFATRALSSNASRLGLQSLLQHELVTAHPVMRSKLNSDIVAQFKGTVLVNADGPTRTTRSWPLPYVHSQYCIPQPTTAAAVLSTPPIREIRQPKPLPAVDVEFGARRIEKEDVEMDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUI6</accession>
    <name>A0A367JUI6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000683">
        <property type="protein sequence ID" value="RCH93555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUI6"/>
    <dbReference type="STRING" id="86630.A0A367JUI6"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016759805" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH93555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="41682" checksum="E6A9FAD7D0EEEACA" modified="2018-11-07" version="1">MKAASLTTIVASLFTGVALARSPVYLLSKDITVAPSAEQISFDTFSMYYSHIMDASSSQRAVVVQDNEWLSFDSNSGLFEKKLDANLVVLVSSVHSPQALLPTKEASFYVDDNDINEYSTLANDVVNDILKNNQDVALTTFKSSRICVKHSDAGKHCVCGEDDDDKSEYFKLFFSNFKTGLFDETKKADAKFMNEVESIRQHWDQTEFPSVNLIEINSLKELAADYGVDSDQYKEAERIFSHLFEKLIIPNFENAYPQKSLAAFIFTPIQTINKRGLDDNDDVCYRTARACRNGTSGCHGHGECVKTGESCFTCQCVSSYTGDACQYVDAVGDFQLLFWTSVLLIVTTASVITCVFKSGSNSDAGIIMTQSLPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWA1</accession>
    <name>A0A367JWA1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000603">
        <property type="protein sequence ID" value="RCH94210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWA1"/>
    <dbReference type="STRING" id="86630.A0A367JWA1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017066633" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="98036" checksum="095A714EBC117B4A" modified="2018-11-07" version="1">MKSLILFSILLSTLSSVHAYYFMGSLTNVLPFKSMMASAQFNNSLYLFGGENATSHYSNDLYKLTQTSDGYSWLTVPQKNPINGTAGSQAFVTSDQQNLVLLGGDSFTEANASNFLPLQIYTYNFASQTWTSKTPTNFTLDNTACVNRQAFSATYDSKNKVSYIYGGFARQSVLDTLHKMDENYQTTSLGRSPEARYGHTTSILSSGQLVVIGGVASINGTSALASMKYVLIYDPVKNQWQRQDVNAMNGYYPSTTSDHVAVVNSNDQIIIFGGDSRDPERTRQYLNAIAILDTKTWTWSVPTIKGIPPSRRGFAVGGLLDGSRLTVAFGGALNNFYNDINVFDFNQGSWLQSFNSSGSGDNSVSKGLIAGVTVAAVILLIIILFLLWKFQSYLRWLIVRIHNDIWKPRTGEPVWAETSRLVSQVFFLFIFIMFLYFVIRQAVESPNVTQRIESSTATVDVPDVRFCFDGFPAQSAAPINGDSGAPGVACMTDNGYSCTSFIRPLNMGEFAPAFADSLGAVNCFLFRAPDSFKLTSTSGANNGSRLLFTLFGDQATSYGRIHLSVYPKNMDPNAIVYGIDDNIPVYLSQGDVFNWQNDERNDLQAENVFTIQPATYSSLSYDIIDHRYLQPVGWNYVGFLPITNSTPQIESYFRSEAPNPNYMNTHTDLGIVAVYPHTWANLIDREVKMYTLVNALGFVGGVFGIIVAAQTWLFGYRPRSPWGVVHRWSTGSRKQSLLAGLQSKFKTTDSGIPLVHPVHHRFSMNEFQNLGQETEAQRVSRVEERMQTLELLFKAYYVDDEVFRSLDNANHILKKNNAQVQPTNNSNPFFASTEKVPTQNDQNGFAHMFNERQSQGSISSDATSQHRLNTAPDVHLRDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWD3</accession>
    <name>A0A367JWD3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_003660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000599">
        <property type="protein sequence ID" value="RCH94246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWD3"/>
    <dbReference type="STRING" id="86630.A0A367JWD3"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH94246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="510" mass="59204" checksum="C2C0A30AA028B44C" modified="2018-11-07" version="1">MNQKVFRWLIITCFIFIAAITTYLLNENNPRELYTEKHLYSTDIKRTTIHVQEPILSFDQVEHLSLKYDFAITDTLKPWTEKDLEFFKTAAGETLFSQLTLISEPNVAPNFAMMTAAERLFKSLFMYFDQRLSQNASLDESWPYYKRLEDALYPWIHPHWENLFHINNQTSGQGIVMCVGNGQFKFAATSIRVIRMLNTKLPIEVFFIREDDLSVAKRYYLKSEMEHVTLRKLDDSISDYYTKFGGWAMKPFAMLASHFTEVILVDADAYFLQDPALLFQDQAYALTGALFFYDRTLFPNWHIGPDWLRSFLPTMSSLVPHTRWFKYTSSHEQESGVVVMNKRKSLLGLLSTCKLNGKSERDEVVYKHVHGDKETFWIGHEIMQTPYAFIKSFGAVIGNMGRGGQDGEPTQVCGVQLHLDTTGTPLWFNGGLYRNKYKETLEYLNFTHFAQGDDWEFATHCIKNTDKIHELSPDQRSIALAAVELDKQREKDEQLLEQGLWKPKKTIASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWJ9</accession>
    <name>A0A367JWJ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_001808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000594">
        <property type="protein sequence ID" value="RCH94287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWJ9"/>
    <dbReference type="STRING" id="86630.A0A367JWJ9"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36469" checksum="3168E8044843A2C4" modified="2018-11-07" version="1">MIVNVMALDQQKRQNEFYEQFPPKETNTKLAELPVGTNEEGKPVVRRGLVANRDISADEDIYSEEPIVSALFPQLEGLYCNLCLKRLDEGNKVECSDCDTVAFCSDECLKHAKNEYHQYLCPKNKQEEETNKEALEFHENLKKSNKKYPYMIARFLSAMVVEELSKANEEQKIGETSFGAWDHVDRFRYLEVAPSDESNEEIEMLKKVLGPKVQGISEFLSSDVYLMLKGKLLYNAYAISASIENDVQIEESKEHARSTNGQTKHIGAGLYKISTYIGQSEESPNVELRFENDKITVKALKEIKENEELVAAYTLPVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX70</accession>
    <name>A0A367JX70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000571">
        <property type="protein sequence ID" value="RCH94508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX70"/>
    <dbReference type="STRING" id="86630.A0A367JX70"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH94508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="455" mass="50501" checksum="62011D02A957305A" modified="2018-11-07" version="1">MDSPLIYSQLINLEDSEAESSDELSSKFIAKDDDVDDSTAIYDTLDSYNKLYLNCLQPYEYNNHPLDKPILKDAIICDAPLGIAYDDSLQQTIDQQKESYSWIYNDPTDNIVKSPGNSRAYVNLNDINSFVAKRDSIHHSTLFPYSEDPYGYLDNYMPPAVFEDSDLEDEEDEDEDDEDEEEDGGGEGDDEGGNDDDIFSEDEWPFYNVTASTNTFHSDNQAKLTIKIKKPFSTTAINSSLFDDWTLPNGQTTMAANIANIATAAAAVAASASSSSSTTTTTTTSLANAHKYRKSMPNIQAVTSKKSKPKTGRRKSTPFRLPEKSKSSNSLCLMTASSSLSSLSSNLKRSMKVSDSLSSLLTLESDLADTEHEDFTAQETEEDKQLLLKQKAKALTLGVQIKKGKNVDKACNHCKRSHLRCDDMRPCRRCIATGKVGCKDVQHKPRGRPKLIKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY50</accession>
    <name>A0A367JY50_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000563">
        <property type="protein sequence ID" value="RCH94571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY50"/>
    <dbReference type="STRING" id="86630.A0A367JY50"/>
    <dbReference type="OrthoDB" id="2325329at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="56843" checksum="988418FF0194B3EA" modified="2018-11-07" version="1">MDFMTGQQQQHGDWLGHHQKKSFILSLPKELLLEIITNVALLESMDSYPTSLIELSLCCKYLYYLVHKDPWRLQTLWSRAFHYRFDTMAIYRRRLVHHIDWQRQLERRFRALYLCRSFALNPTHTRLLEMMDWEIIWNMLIEHDHHNIPLLLKYQVQFAAGVAFQLGRFNDREIYPVVLPILSLLVNYDFTITRFFTFQTASSVVTPEISQFAYNSDADSLITKHTPYKYNYNHHPNSTPIRFYPAQDPIASAFHLFFTTIFAAHPNLYQAIPGCIPIPLFNLQSELFDVEFLRRYERNLFFSSLQQHTIPNIYADTGFASSQYYVSDAHQIEGDWIGYYTFQDTDENVNSMEDWFDGPMRISLRIVPLETDLVQGDTSVTSKEPARTGLFPSAHLRTCPLTRFEGTGIDNSGAFSVSGLIDDSEDGQITWEKNYTESGETWEYSGRFVWPVGLCGRWGDEEYGGPWWMWKMSNNEANVPAIATNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYB9</accession>
    <name>A0A367JYB9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000516">
        <property type="protein sequence ID" value="RCH94992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYB9"/>
    <dbReference type="STRING" id="86630.A0A367JYB9"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="8269" checksum="057E444DE2E07358" modified="2018-11-07" version="1">MTAMDDWISGAPITAPIPRSLYFLAAYFSITIGLFAAGTFIIQEKKTPIIQQLQSAIIASVLLGFGAIFASNAAGVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ42</accession>
    <name>A0A367JZ42_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rho GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000492">
        <property type="protein sequence ID" value="RCH95190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JZ42"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="55"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="342"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="508"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="1012"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1760"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="1840"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1619"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2045" mass="232987" checksum="0ED6CC9D9F689887" modified="2018-11-07" version="1" fragment="single">PLSRSFDEQSISDLTDRDIKNQRPMSMMGIDKLLQEDNKNLIGRPTNNEKRKSLIVIKEGYLFKKTDFRPFHKQAKLDRGWKLYKVVLRGHKLYLFKVTAESPLRSLFPSSPSLSISSSNHDLSTAASLKLVSSEFDRDAQQTLFYSSIDPAQGQIFMELNPVNMQAKRSVQLVVHNGCLYVCYRPDKKQLWTIEEKIPIQQLKLTQISSITDLIDSPTSPSSIKSHQSDPSYQKQSNVTLFNISYVNKPLTLGVYSTQYHYAAQAWIQLFQNNNQRKPPFLEEDLFSSKSNGSTEYYESLHPSETSINATIPDLEPSNDGRMYDATQRHHPDLLHKSQLDDDEIILGGTVTALVQELLMTDNEEYVNTFLLTYSTFTTGSCVLDEIGAFLTHSPGKFDNHLLDIFSIWCNKFALDIMGDVATDILSLLDHIDSTDTSKIKELVLNTVAENAKNTAFSETKYQTNDLNDEEEMETTAMENIPAEGGGSVNLSNLLITGLTPALFLRICPDKFAEQVYLFHLTQYTKHKQALMDPLSYVPRPQISAEMLNSLLFTTASPHFLTKLIRNHILIDSQQEQPGTDGVLLRSRLLNHWISVGMRLYELGDATGWCAVAMGLCSVGIVRLREAWKLVKRDLVSIVLQWTQILTDHGLFEQSFWSDSWEKDLKFAHVLDLGHSQTLPFFGPIRQAVDRQRKHLKKLLMPNVINFEKCSCIYKTIQTSLQAWTPKQPRVVDVQTVGPLQSFFEHSITDLASVPHDFKYLQECSIACEPKIFGQTYDRHRFFQDMPGIAPPSTSILQFPVILESCMFWDNESKRTANESPGIIPPYLNDNKSSKQVNQLSNVVEEAVSTPSRSTGRATLRKRTYSFPPGTALNTDDESYGNEILEAINSKTWLGSIAAGRQHCTYSTKALIEAHWKSRGAQLNDGEVILTVEQEKLAFKVSAILRSKGSKDNLALKRTDSLSSVNILKEEDNNVKGNNTSLSKLLVTVKNGHLVNLIECLVNGVTPYYDTLKEQWQMITLTEGLRYQIDRIIMNETDFMNVFFTAYRSYSSTMSLLTMLQKKFMDAKLNSKLTAKRKNPSLTLLETYFPSDKAKQDMNATQQQGDKDSIEVKSYDWKQVASTQMKIIDLLLYWIDEHPYDFIDEPQSLQLVNIFLRKAQDNLDSWRAPLERYLLNENDGNVNDDEIMKRRNLIKALNISNEIREKIHKLEYRFIQTSLIPCYDMKSIEFNPECLHSAEEVYHELMQGSQFYVSTLQLATSDRTPLSVSPSPVDPDAASLVDRYPPEVLLEQVDKCVCQLFEAATFQDWAQTFDILEVQCNDLYAWLPARKPSRLSKLWTSFAVVSDAPSFHVSNYHVPADEVVISDIFTAIQGAKRPVVSPSAFSDDDFLLAFPSSIQYLYCMHLIIRSWAIQEMTSLKTDVKTRISRIKKFLHIVLLSKMCSEEMSLFPELKGSESVTKKRVPGFVENAIASALVSPEVRLFTKAWNDIALQYGHSSLDSLENLLNKMKQSMDRKEFSTLASFPKSQSVLVPSLGWIFERVIEICFSMPDAVDKKDTTINFDKRRYLYHFLHLIINVQMDINEKRLESKGLSMSFLISPNTSNTSWRELKEYAVLESRKNTSQGSSSGKGLRGPSSKSHASKTTIFSVLVAKQTEKLKRDFKERDRIDKGWLTFQHKQQKKQLEQARAVERHERPQSMMPRLNSFFKGLRPPSLVSSPIHHIFPISNNHDQLAATKASTVINLIHSTTSVASTYMKRDFVFRIVTEEGGQYLFQAMNREDMYDWMRQINDTAREGAAKRQSILIAESMDNESERRQSAVLLTASRSQTISNRKSVYGVPLDVLMRDGQVPMIVEKCIKEIERRGLEEVGIYRVAGTGSIVTALKAEFNKDVNKVDLSDPRWADINVIADAFKQFLRELPEPLLTYTYYDEFINASASEDHDQRVYLIKEVLKKLPYSNYTLLKKIIEHFITVTDFEGINHMYATNLAIVFGPTLLQPAPGPASFATTMSNLGHHQNIVKYLILNYHYLFDVENEAVETKDDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ54</accession>
    <name>A0A367JZ54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_010705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000494">
        <property type="protein sequence ID" value="RCH95175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ54"/>
    <dbReference type="STRING" id="86630.A0A367JZ54"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="404" mass="44464" checksum="9B670EB4FF88D709" modified="2018-11-07" version="1">MSISLAACNTEKPAGVPVQLEDCQRVKLFQPYAQKSVELHNRIVVSPMCMYSCQNGFLNQFHVMHYGSFAFKGAGAVIIEATAVVPEGRISPNDSGIWSDDHIEPLSHVVNIIKSQGSVPGLQIAHAGRKASMSPPFKGDYIESEENGGWPNRVMGPSEIPFADHYPRPNVMTKADIQATIKAFADAAVRADKAGIEILEIHAAHGYLLHNFYSGNSNKRTDEYGGSFQNRIRLTLEVAKAVRAVWPEHKPLWTRISCTDYVNPDPMGSDPDGWSIDQSIELAKQLKQVGVDLIDCSSGGNIKGVQYPNQPLYQVPFAEAIRRQAQIATGAVGLIVEGEDAEKILQEEKADVVLVAREFLRNSTFALSAAQALDVNINWPKQYSWAVKKARRHNTTADEKTAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K175</accession>
    <name>A0A367K175_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000413">
        <property type="protein sequence ID" value="RCH95992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K175"/>
    <dbReference type="STRING" id="86630.A0A367K175"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="18891" checksum="D0C5B149CFFDEDA3" modified="2018-11-07" version="1">MLLYTDIISGDELFSDAFPITEVDDIAYEVDCKMITINEGDIDIGANPSAEGGDDEGVENTSQQVNNVIYTSRLAETSFDKKSYMTYIKGYMKAIKAKLEETNPERVAVFEQKATPFVKKILANFKDYEFYTGESMNVDGMVALLNYREDGVTPYFTFFKDGLSVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1M1</accession>
    <name>A0A367K1M1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000407">
        <property type="protein sequence ID" value="RCH96047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1M1"/>
    <dbReference type="STRING" id="86630.A0A367K1M1"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="400" mass="45964" checksum="C03906FBF35635FA" modified="2018-11-07" version="1">MEVLKALVARIARAFYDPKYIVILDELNNAPPNSNGVKEEDLVLALKITARDIHRICGKLKEDRLIKMVNRMEPRKPDQRMVPKTYYYIDYKEFVDVVKWKMYKMQTIVRDKLRTESENKGYVCPTCEKTFTPLDVLSLVDVADQLFHCDQCETVLVENDNAENVKGSQQVLTKLREQSQPIIALLKQTDSIVIPSSYVYKHVPGSRTNGNRTDDYELATAQDTGAGQGDIIVDLQMDNEAARRAKLEEAEQKRQQNALPVWHQRSTISDTILVGTGDRPAEAQEQEEEDTFEEVGQTEVDADTEDYYAKYYENLSNNITDQPDEAMGEEQETFETVNTGEIDMTNDDSDAEEEFIEDVPLVSVNGKMIPINEVQEEDQHNMTTDEYKAYYEAWEHWQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3P1</accession>
    <name>A0A367K3P1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide VIIA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000337">
        <property type="protein sequence ID" value="RCH96780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3P1"/>
    <dbReference type="STRING" id="86630.A0A367K3P1"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11302" checksum="611A0B2399BED946" modified="2018-11-07" version="1">MDIASALLDITAQLFLFSLHRLFNTTYQSAFIPHFSSSLIKLITMVAPITGTLRKKIIRDISVSLTIGFGAGYYFWHTYHIPSLERRNAYYAKLEASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4M8</accession>
    <name>A0A367K4M8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF914-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000334">
        <property type="protein sequence ID" value="RCH96821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4M8"/>
    <dbReference type="STRING" id="86630.A0A367K4M8"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27705" checksum="8AB6CA6586A4956B" modified="2018-11-07" version="1">MPIAVVGFSFADVGGNVLAVLAFKSTSLLSALVLSSWTIPCVMLLSTYFLHAKYSLIHVRSAVICLVGLALLIWCDTMATDDATANHSWIGDIICLMSATSYAVCNVIEEHLVSHHTTAEILGKAGLLGSLMCGIQALYFEYDTVISIQWTLGSGLLVVGYILCLFTMYSLVPTVYRMTSATFVNMNLITNNFYSLLVGLFFLNAKMPPFYLVAYILVITGVISYSLAPSTTDNDSEEQRQVLKSSDHSITSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K500</accession>
    <name>A0A367K500_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000296">
        <property type="protein sequence ID" value="RCH97226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K500"/>
    <dbReference type="STRING" id="86630.A0A367K500"/>
    <dbReference type="OrthoDB" id="2229849at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13513" checksum="74D5D7A31AA6AC79" modified="2018-11-07" version="1">MSSKSSQSTLAQKRRDLSSFTSCRIIGQHESDKTVQEIKHFLGILQSTIRSVIKKHEEKDFEIPSPRPGRPNNLSKSDATALVLCVKRNSQESFGYHQTTLAQANVEVCLNAVKKAARGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K512</accession>
    <name>A0A367K512_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000288">
        <property type="protein sequence ID" value="RCH97304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K512"/>
    <dbReference type="STRING" id="86630.A0A367K512"/>
    <dbReference type="OrthoDB" id="2202398at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="21254" checksum="2C862CC050DF4D88" modified="2018-11-07" version="1">MVLPLPDTFGSMPPDIAPISPNINPSAPSSTPRTDTDTVNSQQPTATRTYAAIASLPLATKASPKGISTVRKKISSYRSFDSANKTTQSTCSIHRTGTTDHSVFYRIPHRLKDLKVPFSIALSEKFPFGVGLGFTTHEDVQGTVAKVTLISAEHCKEAVTTPLVVENQVFTASPAVQLSLFRTCIRHFVRGPLWCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7X3</accession>
    <name>A0A367K7X3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="2">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_015080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000206">
        <property type="protein sequence ID" value="RCH98323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7X3"/>
    <dbReference type="STRING" id="86630.A0A367K7X3"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF121">
        <property type="entry name" value="DIACYLGLYCEROL KINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="7">
        <location>
            <begin position="60"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="547" mass="62545" checksum="25A5664D9DDB5017" modified="2018-11-07" version="1">MTNTIDNISTQGNIPNISSFVLNNKIDHPSIMTQDHAEKRPMVAKMASSVDFQDTDKEGKPTIYLFIFVNPRSGDQKGGDLVDLPIQHFRMRRFPQVQVEIHNILNDKDRNLGIDNIRLVQSMVAYGKVQPVAEEATKMDTNTDVGHLSRAAQSRQIHVWSAGGDGTVMSVFELLVSHKINLDLIFFSCIPFGTGNDFSQVLGWGRTIPKKDIVGYKLHALEDLIADRLEKSEAARLDIWQVTMTSYPSGYVREAGPKERRDGHDVAEVKARNQEPNEMVRKMSNYMSIGVQGYVGNGFEAHRAGNRLANMFVYAQESSKWVFWRKFPDVNQFIQSINQGNQVLLDCPLPDEKNDKKKSSHVPEMMNCPIDFVIQNIPHIWGREVDLWGEAQSGLESVANRSGPTDPANWLPQRANDGRLEIMTIENMVSYLKKLANIRNHVSRIGQFETPFAIHFRPPEVHESELAKMKKTSWTKKAQAMIKNKTRHKYEKRNVICIMCDGEFYEIKDPKTIEFKLYDQIWTLGRNEKEKQGRLVKDELDTKQDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K893</accession>
    <name>A0A367K893_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000204">
        <property type="protein sequence ID" value="RCH98349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K893"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="100"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="261" mass="30982" checksum="C359FB20272794E2" modified="2018-11-07" version="1">MDKRQAELHRLYKEHESMIDNVRRTLKKEIATLVEEYDLTSEEAHHLNEFIQDKATLFRYLRKNNFNVPTTLSLLLDTIKWRMHQEVDYSMLEHEFFTRPLAYFHKFDKYHRPILIIHLSQLPTLPSSSTDLVEYLSPLIIFVLETARKLVWNLCKQRIEVNDFSVLETVVLIDFKNASSLPMDITLFKSLISLLRRYPGIIGTVYLLNFSWVYQGLWQMCKLVLSEEAKLKVNFPKLHELQELIEPKDILKVTMKPHLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8D7</accession>
    <name>A0A367K8D7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polar growth protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BOI2_2</name>
        <name evidence="7" type="ORF">CU097_014094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000197">
        <property type="protein sequence ID" value="RCH98436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8D7"/>
    <dbReference type="STRING" id="86630.A0A367K8D7"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="340"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="791" mass="90162" checksum="87F57DC76F3FF33D" modified="2018-11-07" version="1">MEVVYTVHKFVAENVDEISLDVGEKVVVFEKDEGYNDGWWKGRNEKGEIGLFPITYTSSTPPRENIEEGVAKLRISSSHLSMSSKNIQSIVKQSLNNPALRMKPIEEWSSDQVALWLIDVGFDKRLADTFKEQEITGDILLELTLDSLKELQIDTFGKRFKIHGAITALKEETKNIKYTPSTNSRLNSPLPEKPYYNNNHTKHPYPDDDLVSDYSTVIRNSQLVNSINNSKRPSIDSTMTSPQRAMSQNNNLSRNSSQISHASSVYRQDHSMQELGRRHTLNTPFSSNNMQEVNILTPCKYNFMRSSLLPSTSKLQSILPSSNMVRRSEDVPMAPELSLIPDMEGWLYKQGDKYKNWNKRWFVLKANNLFYFKSPKAIRMKGIINLKGYRIEVDSSIQPGKYCFKAHHEKERTFYFYTDQEKYMKDWVKALMKATIERDYGTPVMSSSTIPTVSLETARRMRPRPPSTIFHPQQQKSPSSSYRHNSITSNTGLTPMEEHPEELNFQQSFSSPLSSTTGSRTPSMMSPRLRGVPMDNMSEYSFDHRTKLKDSGFTSTSGVMMISPSTTQSSSSSSTTTARKMVSPIHNASSIAPSVSFYPDEEDEDLIDPENMSVIESSRHNHLAVEDLPSSRHYQPTPENQRELLMKRKGYIDWINIHVHDPIRDLTELSTGEILLELLENLGGKEIRRCPVNLNQSVYSQMMDRMITAFEYMHQEGIDLDGGYTFRDILNGHEIKIMALLDAIKSWYDNSVTLALSPKQNNGKKMASGGTFGEEEQNKLRSLDDTESIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8H2</accession>
    <name>A0A367K8H2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_005939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000193">
        <property type="protein sequence ID" value="RCH98485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8H2"/>
    <dbReference type="STRING" id="86630.A0A367K8H2"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="69"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="288"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH98485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="449" mass="48787" checksum="9CB7BB72F429E588" modified="2018-11-07" version="1">MSDHHTMSQERDHDGELTGTDETKTSEKEIKEPTAAQGLVSLLKSSWLNILLICIPFGWASHFIWTPTTTFVLNFIAIIPLAKLLGFATEEIALRTGEVIGGLLNATFGNAVELIISIISLTQNLVTVVQAAMLGSILSNLLFILGMCFLCGGYKHKEQVFNATAAQTSASLLFISVVSLLLPAAFYGSTINTESEDREKTDILDISRGTAIILLIIYFAYLFFQLKTHKSLFLQVPVEAFKIERRSSLIDLLNSGRSQSGIEEQALSYYTNEDDEEEESPSMPCWMAITVLVVVTVLVAVSGEFLVSAIESVVRVWQISETFVGLILLPIVANAAEHVTAVTVAWKNKMDLALGVSVGSSMQIALLVTPIMVIIGWGINVDMSLFFNIYETAVLFASVVMGGKSHWFGGLMLCAVYVIIAISFYYYPDAAAGGLDGPTLNVTIAPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8L8</accession>
    <name>A0A367K8L8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000187">
        <property type="protein sequence ID" value="RCH98564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8L8"/>
    <dbReference type="OrthoDB" id="5366606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="15337" checksum="D932196EB316AD4F" modified="2018-11-07" version="1">MSFQIVLREGIRGGFVGPTTRYAVQIQGDKSGATVTQSTLKPDSRTDYNTMAGGASFEDLADLVQTLKDQLSKLPTEQPPGSEDIYDLDTSIVFACDDFEWCNGGCAQGQSSVQATEEQKEKFKELVELLKGVGQNYAVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAB6</accession>
    <name>A0A367KAB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000147">
        <property type="protein sequence ID" value="RCH99090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAB6"/>
    <dbReference type="OrthoDB" id="2236902at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="200" mass="23053" checksum="A4E5018E4A2891D1" modified="2018-11-07" version="1">MPPSICLKTTYFYPLVPIMGKTGSVLYHRSIAKQTDVSPMDPMIAFCYFFMLQERRILALEKYDDPTIQAIYKKALELLSVQKDETISLTLQAQSFCDAVASQFTKSSSKRLRQYAEDGVQFAQQLKRQHLSTESESVTSIASDNIDKPTADLLFVNNMRDQLSGRFKWTKCYDQGKREGRFTRYCNHITLQDAFYEHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAJ4</accession>
    <name>A0A367KAJ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000143">
        <property type="protein sequence ID" value="RCH99149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAJ4"/>
    <dbReference type="OrthoDB" id="2419780at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="15754" checksum="8DA1A3B0EA8391C6" modified="2018-11-07" version="1">MEKHERIIKNLNEQFRQVDKAYENNDMRVFGKNTTRIFQELDVIRRKQIDLASDHVALEAMNDIPLIKMNHKTDQNNKVYTESFEKKKDMLKNMMKKLDELTQAMEQFKNISKPDYQGNDSLQSFQHQKAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAK2</accession>
    <name>A0A367KAK2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000135">
        <property type="protein sequence ID" value="RCH99262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAK2"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30689" checksum="9AC6CCAA8F599D60" modified="2018-11-07" version="1">MESFTGYIKTPQDALIIFEACRKGLLQRVKRRLTSKERTEIRSGSVFAWDEREAGMRRWTDGRTWSPSRVLGSFLTYRELDTKRRPRKPSMAIPGMKQVVFSYKPNGLIKQSFSICTASNQKLHLISYYKKADIISGHLKRPSDDPLLNKLEIPKGQYPEINPLDIGGGHTASIHSLQYYNPTRQNSTDSSIISASPSLTSSPWSSDEEYYYNNNNNNNNNTNELQEPELIPFPPIRSLPAQDVAWEKLPWSEDHRQLSALYHELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB29</accession>
    <name>A0A367KB29_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000127">
        <property type="protein sequence ID" value="RCH99377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB29"/>
    <dbReference type="OrthoDB" id="2287642at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11730" checksum="895761287F00275F" modified="2018-11-07" version="1">MSNVKAIYSTPNCNKVFEIQQDSAAIENITGSILQLKDQLNEFLTQIMEKETLPTNTTTTQDDIEEQEDEEQDKDEDGDSPMSIDRPEAPEKQNVKKPKINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC19</accession>
    <name>A0A367KC19_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000100">
        <property type="protein sequence ID" value="RCH99793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC19"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="65" mass="7007" checksum="32B67B2C9B8CAC03" modified="2018-11-07" version="1" fragment="single">KHKGDVTGALVIGLGLLAIFTNQHDPWIHWSALVAAIITLIYPARPYVFKLVGRDSSAENAPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDT8</accession>
    <name>A0A367KDT8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000066">
        <property type="protein sequence ID" value="RCI00337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDT8"/>
    <dbReference type="STRING" id="86630.A0A367KDT8"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="401"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="556"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="633"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="707"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="794"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="873"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="910" mass="100006" checksum="21372F74D9217E37" modified="2018-11-07" version="1">MASNESSLDSLPPSAQLALLHAQAAAAAAAANVTNTELNTTTTTTTTMTETVATIAEEDKFVPSPDDPVVMDNSHFEPLISGDFPTPIGKKPVTPVKKETPSTKKNLDLSSEAAFPSLSASASPRTPVVSGWSANAASRLKSSPQAPVRTRAMAPSATGKKNTSTPITDVLELPANQQIANAQNKPLGFKGNADVIQKVMNRTGTNIIASTNRSGTTTCLIQGQPADVARAKKELINGLLIKRVYSVDIPVSVRRFIIGPKGTTLRQIEEKSNTRINFARKEEEDFDENDPDDTIPLTIVGYVTDIMIAKEEIEKIVAEKRAKQTIKIDQFDAKYYPFIAGPHNSNIKKLEEEFDVKIHVPFIAIDGNNVNSSPITITGDKEKAQAAKQALEKNYVTIESTGTVVSINASKRQQKYFRGNSEIFKEIFNETGCTVELPSQDDASESIVVRGPETQVVQALSLVMAKVKAVHISVLDLAQIYSSYGKDSLTYARYALKYLLDKRALKGIEKEHNVQTSVPSDEELEKSVYVEFISKEEKDAAIAQLALTNAVRKLTPDRFSTIKIDAYLHQHILNTYRARIQRIKEAQQVDIIFPGEKDQDVLIVYEGDDKAAVKDALAAASAALKEIVSDSSDYVSKSLSIPANYHDLIRGPKGTTLNAVLGLNSGVTVRFGPNDTVEVRGFSKQVNHAISEINKTYQEAQDKNFAKPYSSEFSIPSNFSAHVIGKSGANINKLKEDFGVRIDFGDSDKTEEKVNGKDSKKKAAPPVKVTIQGIKTNVEAAKAHINAQVAMLADQVTLSLKVPKEFHRYLIGPSGRYVKKLEDKYNVFIKFPKSTQGDESPSTGNPDEILVRGGKKSANAAKEELLELYEYEKEEQEKRKERELKQKQYEEKRNAEEKRKAEEKASKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE67</accession>
    <name>A0A367KE67_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytosolic Fe-S cluster assembly factor cfd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CFD1_2</name>
        <name evidence="13" type="ORF">CU097_012318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with NUBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000056">
        <property type="protein sequence ID" value="RCI00514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE67"/>
    <dbReference type="STRING" id="86630.A0A367KE67"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000796">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="28839" checksum="8399730CE64B4FB1" modified="2018-11-07" version="1">MSDINLSNIKHIVLILSGKGGVGKSSVTTQLALGLVQQGKKVGVLDIDLTGPSIPRMLGLDGKKVHQASQGWIPVYADENQRLSCMSIGFLLESKNSSVVWRGPKKNAMIKQFLQDVYWGELDYLLIDTPPGTSDEHISIVEYLKTCNPDGAVIVTTPQAVAIADVRKELSFCRKVGLPILGVIENMSGYICPHCAECTNIFSSGGGEAMAKEQSIEFLGRIPIDPKFTTMVDTEGAGSYVHMFKESGLFSIFQQVCEKVDGLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEB9</accession>
    <name>A0A367KEB9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosyl-DNA phosphodiesterase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000058">
        <property type="protein sequence ID" value="RCI00481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEB9"/>
    <dbReference type="STRING" id="86630.A0A367KEB9"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF3">
        <property type="entry name" value="OS04G0403400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23625">
        <property type="entry name" value="UIM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54705" checksum="BC0F17D9AA3D284A" modified="2018-11-07" version="1">MSDYETDMRKAMAESLSHHLQEQEKENDDLKKAIAASLGKTVEQLTARDLLLATDSVRKRQRSEDQSSIVTTKRVDTSNSKYWDGTVKLTYVKGFTGPNYIKLSDIVQRNDLKKAVITSFVYSMDYIDEHFPLDANIVIVGHGRPAMSVQLGPKRVLIQPPLKDERYGCFHNKLMLLFRSSSLRVVIGSANLVPCDYEDLDNVVFIQDFPQFTEPLKSTSELPVFAKELYDLLDKMRVPSSVKEELLKYNFEKAKARIVASVSGIFEGEKEYKKYGHTRLAEIIQDITGPLEADNHPKVEMQTSSLGSLTVSYLQEIYQSFCGILPYADGKAVRSSFKKNEIPPVDIVFPSRCTVQDSRYGPPGADSICFNTATWRKPTFPRQVMCDAISHRQGTLMHSKYIISTLPKGVGKVKGWVYCGSHNATTSAWGKFTMSKASKLPKLNISNWELGVVLPLYEDSNIPAPYLRPPPRYQPDQDAWTQNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEJ4</accession>
    <name>A0A367KEJ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative lipoate-protein ligase A</fullName>
            <ecNumber evidence="5">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AIM22_1</name>
        <name evidence="12" type="ORF">CU097_013674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[lipoyl-carrier protein] + (R)-lipoate + ATP = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000047">
        <property type="protein sequence ID" value="RCI00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEJ4"/>
    <dbReference type="STRING" id="86630.A0A367KEJ4"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="54"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="42162" checksum="A04BC1E2B0ABD5CC" modified="2018-11-07" version="1">MLFLQRCFTVSSRHGVRHVSTVRAQPSKVDCYISTINDVYWNLAIEEWLLRETPADRFILYLWRNRPCVVIGRNQNPFQECNLRFMQSQHIPLVRRRSGGGAVYHDMGNSIYTIFMPREAFSRRANAELVARSLNQLDIAASVNERHDIVVDNKKVSGSAFKITTSRAYHHGTMLIDANTETLKNCLSKKRMSNKGIVSKGVASVPSPVTNLRDYSYTVDHQQFCESVLSEFVKAYNDGEPVEPIVFDKNSVLPKKVTETRNELTTWDWIYGQTPEFTNSVETDFEWGHVKAHFLVRHGKIKSASITTDSQSMYGPTISAAISVALEGLAYSEWVLDKAIEKINMEVPGLIHSDNEQVVVDICQWLRNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF74</accession>
    <name>A0A367KF74_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000036">
        <property type="protein sequence ID" value="RCI00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF74"/>
    <dbReference type="OrthoDB" id="2287593at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="179" mass="20995" checksum="43D7621553031890" modified="2018-11-07" version="1">MPNSQKVIVPVDVQILKRQLKGAVGSFIEDKLPSILSTRYNTSNLQSHLDNMIYEYCANTISTDRRIISESCILEHQHRFLVKIENFMTQQVQDILYQVNEFDLPRLFEKTRAQISGILIHFNQHIMNPLHHRLELKQKQKGNSKQWITDDMLHEFVSIVSHAEDQEDNNIQHFISLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF79</accession>
    <name>A0A367KF79_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000058">
        <property type="protein sequence ID" value="RCI00482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF79"/>
    <dbReference type="STRING" id="86630.A0A367KF79"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="213" mass="24105" checksum="299F2BC423F82706" modified="2018-11-07" version="1">MPFSNLFVSKHRKIDFSINVTIQDLANVPLVSGIYHVKWKLKNAEHTSGSTSRSPIRDHSIFWGYPINTLAHLVISKDNILGPCELKLQVFQEIGGKYAGSGLVSRRYLLDECKFNSTIKLSIRMDQVSESTTSYDTPPLKKQQAFIDIPTMIINERQAQSEQQSTSSSDNQEIKRSKSSSALPQYCRQVTPFHNTDDPSPTDLVDKLFKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG85</accession>
    <name>A0A367KG85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_013892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000019">
        <property type="protein sequence ID" value="RCI01234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG85"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="178"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="317"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI01234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48776" checksum="ACCF9BCA876B1A56" modified="2018-11-07" version="1">MAPSDTPSELVAKGGDSHRRWYPYILNSNNIPAFLQTPYMHTLSSGNLQQKRKKAREATSIGGSTAFARTLIMQSLYLFYRTPIKLFRPLRVDYLVMARALMPVDAANAKRFSFRYTSIGMISHAVKTKGWNFIPRHILPPLIANTLIGTVLYTTYIAALPMFHPPSAYQLHRPYPPPPYSSVFAAGCLAGAAQSIIATPLDSLKVRFEVNDLLEGKHHSMYQFAKSTFKELGIASAYRGFTLTLVRDSLSCGLFFATFEWVKQQGYYYFLDEIYGVHVDSPSTIMELETGWSSIENDDRPTSSDSCEKREKPPLMLEPLFVIFAGATAAMAYQLIDHPLSKVHSIFYIEEGQSEFTNKHRRESVRSLYRRTLDQCLTQVKLNGGSWRKFLYQEFGSTVVRVVPATSVGFLVFELVKREIDFRSIDFDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGI2</accession>
    <name>A0A367KGI2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein transport protein S9 plasma membrane t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SEC9_2</name>
        <name evidence="5" type="ORF">CU097_015715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000019">
        <property type="protein sequence ID" value="RCI01240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGI2"/>
    <dbReference type="STRING" id="86630.A0A367KGI2"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="258"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="321" mass="36774" checksum="43D267040C06C87D" modified="2018-11-07" version="1">MFWKKKDKTKEESTNPFDTSSVASSPAPSYSSTPSAAPSYSSAPPSDYGRTNSNRDELFAGARNNNYNQDAYSSSRLGQNNRERLYDEEQDEEVEVAGLKQKIKNVKQDSLASTRAALQRLHETEATAANTMNMLGEQSTQIANVNRHLDMSKAYSDRAANQAEELRQLNRSIFIPVVSNPFRRKERERKELERLQQDHAEHMEERDRIRQFEYETKARIEETNRANEGQKNIRSAGRRGRSEADRRRYQFEADSEDDAIEDEIDQNLDLMGDALAGLKNMAITMNTTLDDQNKQLGRTIDKVDPLSRNLIKTTDKLNRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJV8</accession>
    <name>A0A367IJV8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005512">
        <property type="protein sequence ID" value="RCH77962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJV8"/>
    <dbReference type="OrthoDB" id="2231406at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH77962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="111" mass="12938" checksum="2176B28402AC2B2D" modified="2018-11-07" version="1" fragment="single">MQEYEQRHVEQLQSSQSELERLKAKEANVIEEYKIMLERDKQTKLGNESMEENIQQLDVQIAELQREKESLMKQVQALREEEFSPTNIPSTELTLALFEGLGVKPVMEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILP8</accession>
    <name>A0A367ILP8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005034">
        <property type="protein sequence ID" value="RCH78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILP8"/>
    <dbReference type="STRING" id="86630.A0A367ILP8"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19196" checksum="5C06E5F1FC432584" modified="2018-11-07" version="1" fragment="single">MDVLRFMFGEDKIVTKAPAASNIWTNAARFDPDAEDSYKYLTTNKTEDTSKDNESDHDTEMEKAKEDEQSDDDFFDKPNQPQSIAPEVSTEKHFEVNTNLKPLFGGSEGTFKLFGDDNEEDKVEEEQAFVENTPTVDYSLNFASTTKASNTMGLGIMFFFHFDDPELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILY6</accession>
    <name>A0A367ILY6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004989">
        <property type="protein sequence ID" value="RCH78679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILY6"/>
    <dbReference type="OrthoDB" id="2272470at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="190" mass="21478" checksum="FA3D8EA364067BBC" modified="2018-11-07" version="1" fragment="single">QPKLSNDIGFAAVPRSADDKDVLLKEELTCEEDALLELSLSGIYNYLNPYMKKVYQEKLNRSPPSTIIATATATNSVAEAMTGVRNLLDSKKDMNDILYKVQLEKARLVKEKLRHSDMYKALAILEKVQLWNEVGDEQEMTFYRRFASYLDTLLIETDLNMIDGETGCSSSKIAIETNKQLFHVEDSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPX6</accession>
    <name>A0A367IPX6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004308">
        <property type="protein sequence ID" value="RCH79747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPX6"/>
    <dbReference type="OrthoDB" id="2287075at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="74" mass="9125" checksum="B49FB4E02EBDAA4A" modified="2018-11-07" version="1" fragment="single">FFFINELKKSEFFDIQKHARKEFYMQVFMAFVQQKKKVPARTPKSKEFRDLIEKYLEEYRQLSSYAPAELKYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPX7</accession>
    <name>A0A367IPX7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004307">
        <property type="protein sequence ID" value="RCH79750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPX7"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="380" mass="43012" checksum="FB5D252704F08AD1" modified="2018-11-07" version="1">MLSRLTASIGNKYIRSNTSNRLLLNQKRAFGFTKSISREAADSTKAVKFTTSTYNDAISRLKSQGKLAGKITVYTVLSVSAAIGLIWQLAHLYIEYTMESTPKELGFKGRQLLHGAYVREQLAPDYDIASMYIREVIRIALEEQNLKENSDTIINLRLRLAEDENKSGNLLDAITEYTRAWKLLMDNGKGHDQQTITAAKKIGDLYMRIDDYEHAEEFLAWALHMSEKANQDDLLQSKIKLSLANMYAIQRNFKLSIPLLSQLLKSLPEEQHCLRAIVQNQLSEIMYGLDKKDEAMGWAQTALETCTKDIKNQDCLECGAVASNNMGRMLELSSEFEQALAYYNQAIKYASDAGNLTSHESYSLNSERVQDIIAIKETKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQC4</accession>
    <name>A0A367IQC4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CLIP1 zinc knuckle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004218">
        <property type="protein sequence ID" value="RCH79900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQC4"/>
    <dbReference type="STRING" id="86630.A0A367IQC4"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLIP1 zinc knuckle" evidence="7">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH79900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="385" mass="45647" checksum="C2C6EDDA19C5CEB9" modified="2018-11-07" version="1" fragment="single">REMQQSAAQMDQLRAQLSDRGRTLATVEREYAELRTAHIETMQSYQQLVIRMKQEHTEAIHQKDLQMHELEKKMERWEEEREEAENEPACRRLQAQLELTTQALDREREQVQAMAAEISRLKCDVKRVHRLSTSSTLECHRLQSLLDQEIQDKRRMMDEINAAVETQMRLEEENEQMRINLDKSQRDLADALKRLVTLEKQKIGSNDGLVEQLRQENNAWIKSYQRAEQECLRWMNEGLEKCPHEWLLEQLRREEERHQQAQYVFQQTIERLTKELCDVESLVEIKVLRETELEEQLEQEKRKVMALEDRVRHAIILTPTSPVCQLKDLNVNPYCEICEEYGHDLMQCTALSDLSISKPNHLYCVNCDVFNEHSTDACPNQDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQF6</accession>
    <name>A0A367IQF6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004223">
        <property type="protein sequence ID" value="RCH79892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQF6"/>
    <dbReference type="STRING" id="86630.A0A367IQF6"/>
    <dbReference type="OrthoDB" id="2447276at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="100" mass="11493" checksum="E26299ABC5579B00" modified="2018-11-07" version="1" fragment="single">MSWKNNTGDFGASEPQSLNNSFSPEEEQKRQAYRDFKWASNRSRYEYNENTVDENGMAPRDEALEQELFGSERQDGIDFSKYAKIPVKVERGAAPPPIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS26</accession>
    <name>A0A367IS26_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003886">
        <property type="protein sequence ID" value="RCH80494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS26"/>
    <dbReference type="STRING" id="86630.A0A367IS26"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH80494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="255" mass="28297" checksum="3E4D8DA0CC614200" modified="2018-11-07" version="1" fragment="single">MSLGRTLKLNTGATIPALGLGTWQAQPNEVYHAVLAALETGYRHIDAAFIYGNEKEVGQAIKDSKVPREEIFVTTKLWNTSHRPEDVEKALQVSLENLQLDYLDLYLMHWPVAFKPGKENVPKDADGNIQFDDVDFTETYAAMEKLVGDRVRAIGVSNFNIAKLEKLAKTQKIVPAVNQVELHPFLPQDELVKYCHDHGIVVTAYSPLGSTGSPFLKDEKIAKIAEKYNATPAQVLISWGIQRGCSVIPKSVNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS34</accession>
    <name>A0A367IS34_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003885">
        <property type="protein sequence ID" value="RCH80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS34"/>
    <dbReference type="STRING" id="86630.A0A367IS34"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629822" evidence="2">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="13581" checksum="F85318C4AE7C78F4" modified="2018-11-07" version="1">MRSTLISLALVATLALVSALPSNLNADVVRRDATLAKKSTTGAIYRRALNREASRVVRRDEEEDENEEDEDEEEEDDKGDDDEEKSSSHQRRDGLLGGLLGDDGILGDDGLLGGDGLLGGDGLLGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISH6</accession>
    <name>A0A367ISH6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SUP35_1</name>
        <name evidence="16" type="ORF">CU097_000739</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003817">
        <property type="protein sequence ID" value="RCH80623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISH6"/>
    <dbReference type="STRING" id="86630.A0A367ISH6"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="122"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH80623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="51704" checksum="B3A1501D90B66A06" modified="2018-11-07" version="1" fragment="single">MSEDASKSFSKLSLNPAAAEWKPNLNAKSFVPTFGAAPAPAPKVVKLPESTPAPAPKAEEPKKEAPKAEAPKPKPAAAAAPKPAAPAAKPAAAAPAKKAPEPAPQEDEEEVDEEIAADLYGKEHLNVVFMGHVDAGKSTMGGNILYLTGMVDKRTLEKYEKEAKEAGRESWYLSWALDTNAEERAKGKTVETGRAYFETDKRRYTILDAPGHKNFVPSMIQGASQADIGVMVISARKGEFETGFERGGQTREHTMLAKTSGINKLIVAVNKMDDPTVQWDKSRYDEIIAKLTPFLKQTGYNPKTDVHFMPLSGFTGANIKDRDPKSCPWYDGPSLLEYLDAFKPTDRKINAPLMIPISEKYKDMGTIVVGKIESGHVKKGSRVMLMPNKQSTEVTAIYNETEEEVEAAFCGDNVRMRLKGVEEDEVMPGFVLCSKKNPVQTTTVFEAQLAILEHKSIICAGYTAVLHVHAAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISY6</accession>
    <name>A0A367ISY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003735">
        <property type="protein sequence ID" value="RCH80788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISY6"/>
    <dbReference type="STRING" id="86630.A0A367ISY6"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH80788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="25898" checksum="9A4B7E73EDF5B9D4" modified="2018-11-07" version="1">MNGRYSAKNLGVKRIMQEAKEIAAENAYEYSAHPLEDNLFEWHFTIRGPDGTDFEGGRYHGRILLPSEYPFKPPEIMFLTPNGRFELYKKICLSITGFHPEFWQPAWGIRTILLAVIAFFPTEAKGAIGGLDYTQAERRQLARRSREWICPDCQAHMNNALSDTKRELKAEREDIPSIAINYKAEDESSSLTTNSSSNTRQHLSTTPNQDGSGWADPPGHQEGVSSQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWZ2</accession>
    <name>A0A367IWZ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ISU1_1</name>
        <name evidence="10" type="ORF">CU097_003792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003139">
        <property type="protein sequence ID" value="RCH82129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWZ2"/>
    <dbReference type="STRING" id="86630.A0A367IWZ2"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH82129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="156" mass="17189" checksum="2C19248E16DE45BF" modified="2018-11-07" version="1">MLRNTLTTITKSSRLIQKPLSISGTRFYHEKVIDHYERPRNVGSFPKTDTDVGTGLVGAPACGDVMKLQIKVDDATGKIVDVRFKTFGCGSAIASSSFMTERVRGLTLEQASQIKNTEIAKELCLPPVKLHCSMLAEDAIKSAINDYKKKRSAQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXC7</accession>
    <name>A0A367IXC7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003082">
        <property type="protein sequence ID" value="RCH82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXC7"/>
    <dbReference type="OrthoDB" id="2280645at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="696" mass="78477" checksum="DBAB72A555F96585" modified="2018-11-07" version="1">MGQTTSAETTKNTEDEEEQIQDKRARGKKFDLKNINDHTQDDVTQSPTDSFFPIMNTAEAPSDETVAMSSSVVETTSSLKENSFKTNRNANNSVGIASKIIPKRPWSSYHLFQLANTTTNNSISDSKARMIRSPRIRPRESKGTDTKSKARIKFAEPPKPIFNNNRHQLEKLAKQNAEIDEIITMLHHHKISEDESIINQTNDYVPSSEFQFSFPTANNNGTYIPRQQYLVPPPPPVIINDEEDEDEDEDDLQHDNNNNNNNNQFKYDVIKNRKILPLPKRKLRRNLDSTSGVSSNGSSVLSSPIPSLPSSPFTFSSDKPMPKVSFLTDASRNLLQQQQQQQQQQQQQQQQYQGQDQQSQQQSQQQQQQDSSNVGSVADSAHNRKDRPNMSKKIKSMERVHTTPLNDEVTMIGKRKEITSNNPVFKSPPKMEVFTKYNPPKVFDFTNFNFQFNPDPNNNNSNNNNNNNNSSSSSNETKKMIQNTHKPTQAPFIAPDQPISTATSNDPSTNTTTSTTIPTFGQHVTPGKPIKGVETKKTLNAKAPSAAIKRPSISQPTNTTTNNSISTATTKAKVKQEGESKKKTASSNSKSNKKNKKSKNKKSEEASPGGFLSSDITLFENPLSDDWICFFCQFDIFCRGFEDAKKKNGYYKRKKERLRRANEARRIAAGGGGVESSEEQLEEEHRHYHHHHHHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXK2</accession>
    <name>A0A367IXK2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC25_2</name>
        <name evidence="4" type="ORF">CU097_005377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003016">
        <property type="protein sequence ID" value="RCH82430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXK2"/>
    <dbReference type="STRING" id="86630.A0A367IXK2"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="210" mass="24726" checksum="4EADF3A90856178F" modified="2018-11-07" version="1">MVLYFTSNVVDPPVTIYMGKDKFENEDLIKYGFPEDFHVDKLSSAHVYVRLQPGQTWLDIPPEVVDDCAQLVKANSIEGNKKNNITVIYTPWDNLKKTPGMETGQVTFHNHKKVKRVHVEKRINEVVNRLNKTKVERYPDLMQEKIQREKMDRKKARADEFAQKEEARRLAEEKRRAEKEINDLFDPSLMKSNWRETEVEDINAAEEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYH8</accession>
    <name>A0A367IYH8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARP2_1</name>
        <name evidence="8" type="ORF">CU097_002730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002913">
        <property type="protein sequence ID" value="RCH82738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYH8"/>
    <dbReference type="STRING" id="86630.A0A367IYH8"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH82738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="498" mass="55993" checksum="CDC3BF3FD61437F9" modified="2018-11-07" version="1">METVAFEQSMWPFSMTKIDGKRMDDSDSFEKGLSCNLSPCPVDYWFNTIDHPEIAADAFGRAIAVFSKSSINGAIHTGSTLFVPFATEPANMAYCPIDVGAILFKMNASKTLVVDNGTGFVKCGYAGSNFPEHVFPSVVGRPILRAEEQVGNLQVKDIMVGDEAAQLRNILQMSYPMENGIIRNWEDMRHLWNYTFDEKLKIDPRDSKILLTEAPMNPKQNREKMAEIMFEEYGFQGVYVAIQAVLTLFAQGLMSGVVVDSGDGVTHIVPVYQGYAPANLTRRLDVAGRHVTRYLIKLLLLRGYAFNRTADFETVRQMKEKLCYVSYDLELDQKLGNETTTLVESYELPDGRVIKVGSERFEAPECLFQPNLIDVEAPGMAEMLFNTIQAADIDIRADLYKHIVLSGGSTMYPGLPSRLEKEMKQLYLTNVLNGDASRLSKFKIRIEDPPRRKHMVYLGGAVLADIMKDNESWWVTKQEWEEMGPRSLEKMGVLGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZB8</accession>
    <name>A0A367IZB8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cilia-and flagella-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CFAP20</name>
        <name evidence="2" type="ORF">CU097_002726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002797">
        <property type="protein sequence ID" value="RCH83036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZB8"/>
    <dbReference type="STRING" id="86630.A0A367IZB8"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23950" checksum="B884235529A97D20" modified="2018-11-07" version="1">MFRNTFQSGFLSILYSLGNEPLQLWSCHLPEVDKDNEAHIKRVVDDHISSAVIELCSPNLSNTYITCPAQANKTLGIKLPFVVLIVKNLNKYFSFELELLDDKDEKRRIRASNYQISTRVKPYIATMPMRLDPGWNQIVVNLADYVKKAFGTNYSETSRVTVHANCRIRRIYFTDRLYSEEELPSEFKLFLPVSMSMCVCVYMSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1Y3</accession>
    <name>A0A367J1Y3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002507">
        <property type="protein sequence ID" value="RCH83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1Y3"/>
    <dbReference type="STRING" id="86630.A0A367J1Y3"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="37431" checksum="14828BE18F2D7088" modified="2018-11-07" version="1">MSNNQQTLEDRLLRMAATDVSDLPAFPDNKSDLPSDFEYDPNNYEQEEEVVEEITEAELLKYLDEQEDALSIVQRLFYHELNTTEYQHQCSSWDLQCLTPNDVEELYGKGWTEIEGLIDLNILRGAFEESRNLQECNSFVPPSQLKETLDDPYRDVTARGDSIIWLDPQGNVDNQASIEPPPYLEKVLAFLQGPLFHDISRMIRLIGQRLECQLSFYHSNGARYERHRDAFPTDDPNDLYQRRVTVVVFLNPGWMSGDGGELKIYGRKDKKGMPEGAERVIRPQLGRMVIMMSGAIDYEMMPSYKDHFMLTTWLRAIMLPKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J220</accession>
    <name>A0A367J220_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002563">
        <property type="protein sequence ID" value="RCH83761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J220"/>
    <dbReference type="STRING" id="86630.A0A367J220"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="133" mass="15355" checksum="348CD957C1B4401B" modified="2018-11-07" version="1">MSTIGRTVKNFLKVGPSSYFKQMNTIGDTKWGRLVGVDANGNKYFENNDEVSGRERWVEYASQSWPDPGDIAPDWHMWLQRIVQEPPTEMNLKTEKWYGEPTPNFSGTSKGFRTYNTTAPKLYSWEPVVKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2D8</accession>
    <name>A0A367J2D8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002460">
        <property type="protein sequence ID" value="RCH84107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2D8"/>
    <dbReference type="STRING" id="86630.A0A367J2D8"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="483" mass="54992" checksum="69396E670C6498C0" modified="2018-11-07" version="1" fragment="single">HAPFAKFPPMKVLMMTLNQSPPTLNRDQTKYKYSRTFKEMIDYCLQKDPNKRPTAEKLIQHPFFKQAKKKDYLVKAVLACVPPLDERPHKKIAFKQTTIENSDQWDFDDTSPHEKSRHITFGNVIKNTDKAIGLPSPAPSEPEISSPSFHRRSRFVIDDYTHPSPMSASPPQTYDSNSWQSSVGLGLGILHQQENSEIKKGRFSVNQASVPKPENLPFLATNPSQDIRPIPMSRALSNESTREGRRSRFEIQHLSSQSSGTTTLGTTPLYTQDIRTEPLTRESSSYHQRSSSSSSGKIGRFSIEKEHTTDMVHPHETNVQECRKKGRFELTGAPLPSERFESFAPTQQPGMQHHVETLLKQLEIQKTILFDILHTIPNRSRSSSIDIRKLSNSSLDNNAENYFQPIAARPPVQNYIHTTIDHLQQVLTNAHQEKERLLKENEALKMEIERMKRQPTSILKTSNTTSSSRTPSVSFLVLKDTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2Y7</accession>
    <name>A0A367J2Y7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002406">
        <property type="protein sequence ID" value="RCH84295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2Y7"/>
    <dbReference type="STRING" id="86630.A0A367J2Y7"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="266"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="371"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="489"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="562"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68402" checksum="9CA50140F9189860" modified="2018-11-07" version="1" fragment="single">MANSGTDSTNSLNDNDSNCSPSGNTNYLATKTWHKKLAQEPLRRPRAETAPPDPVIPNNMRNPTHVFTSSLFNAQSQPLWDGQPHSPTSDQLLREDSHHTIASTFASLGLDDSRTLDNRRTIHASHSYSSLQFLAETHQQQQQQQIPYDSFLKQRPPLMDLRLQGNRPRAMSAVDSLEEQQQQDHPPFQSIWHPRLPLENNIRRPFLRNSNSSADLLEMMARQRKASTTSSSPIYHQDEPELATPPTAWESFEDAEIVPHGQIPSRSLWIGQLDLSITTNDLNNLFSKFGSIESIRILPDRECAFINYFGVEEALRAKDALIHKMNSKLGNSTIKVGFGKSESVPQQLSSSTSSQSSQSQLLTDSVQEPTRALWIGNIPNNTTQVALGTVFSTFGAIESVRVLPHKNCGFINFFNLEDAIRAKKSLHNREIMGPGTGMIKIGYAKVPSLKTMEDDVEKEHQQYQQQMMMYMMTEMMTHNPNMVSAIISERKMIMQDFGEDEKDGPMFQGEVLHLPQHYFHTIPAAPELGQSRKVDIAKLRDIRKRLDNGQISVKELEVIAVECLDELVELCSDYIGNTVIQRLFEKCSEMTKSLMLERVAPYLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J391</accession>
    <name>A0A367J391_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">MED10</name>
        <name evidence="7" type="ORF">CU097_007442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002378">
        <property type="protein sequence ID" value="RCH84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J391"/>
    <dbReference type="STRING" id="86630.A0A367J391"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="16223" checksum="FF48101B743629F4" modified="2018-11-07" version="1">MQSDEISSNEARNLLKEQLNELLQNLFELSVIVYDFQPDGNRLVWKKINSIIEHYKEINELREGITEYIPEEVINYVENGRNPELFTQSFVERTATENQFTNGKIKAVDEFKQLLTEEFTKSFPDLYDYEDAIDTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7E6</accession>
    <name>A0A367J7E6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_008687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002005">
        <property type="protein sequence ID" value="RCH85830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7E6"/>
    <dbReference type="STRING" id="86630.A0A367J7E6"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="249" mass="28392" checksum="D93ED4465C39829E" modified="2018-11-07" version="1">MLDFIKNGFYNSIQTESDQLRPHVYVNVYDMLQPNYITNIGYYAFGLGIFHSGVEINGKEYCFGGHAMSNVTGVFVVEPKIGIPELILKRTIDMGPMRLTDKEFEETLTAISDEFTGPSYNLLMRNCNHFTEEFVYRLTQKRTPAWINRAAKLGTMFPCVVPWEWIQPPELGEEEEEEVEPETPQSVPNSTRPSTTIQRRSSTVSLLSNRHPPYSYTEGRNPSQERLVPPVVNFQGIMLPASSETANRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8B9</accession>
    <name>A0A367J8B9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GPA2_4</name>
        <name evidence="11" type="ORF">CU097_006581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001918">
        <property type="protein sequence ID" value="RCH86204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8B9"/>
    <dbReference type="STRING" id="86630.A0A367J8B9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH86204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="355" mass="40877" checksum="D2BB23E54CC8CFC4" modified="2018-11-07" version="1">MGLCQSSEKDNPERKRSNEIDRYLEKERGIREKECKILLLGSGESGKSTILKQMKIINLNGYSSDELFAWRATVYRNVVESAQALIQAMAKLGVDYEKAELRENVDKVLEYRVSGNPKSQLSPEIVAIIKLLWQDKAVLSYFEKRDKTFYIMDSAPYFFDSMDRIGQANYIPNEQDVLRARLKTTGITEIQFQMGGFSVHMFDVGGQRSERKKWIHCFDNVTSVIFCVALSEYDQVLLEESNQNRMLESIALFDSVVNSRWFMHSSIILFLNKVDIFKLKVRSSPLNHYFPDYGGGSDANKAAKYILWRFLQCNRNKLSIYPHLTQATDTSNIRFVFAAIKETLLQNALRDSGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8Q2</accession>
    <name>A0A367J8Q2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001897">
        <property type="protein sequence ID" value="RCH86307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8Q2"/>
    <dbReference type="STRING" id="86630.A0A367J8Q2"/>
    <dbReference type="OrthoDB" id="2157701at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="339" mass="38731" checksum="6EB6D9789765F7DB" modified="2018-11-07" version="1" fragment="single">MSAKDYSYSQRPTLRRIIWISYARLITFFIPDVLLHYIAGLNTSGSRIAWREKMALLSLFLFSATCLCVWLEYVSNLFCNPIKYYYYRDVLTNNSKLSVIHGTAVDWSGYSSDAANFIKEHPHQDLSYNFPRFLHLNQSNLDYNEPILNNCIYSLNMTDRADAWLRYYLTKHPGYDYQDDTLLHCPIPGKLNMTGAPCFDGTSAMNGYRIKGDVLYDPFSVKRYYSALPSTNNMTRQAFVILDGTVLDVTAYLLGATDTVIVAPHYTSRSFAADRTFLPIDLSLYLYTHLGTDITDFFESNSALGYDVYRQCLIYLFQTGVSHISAGCSRSNPAMWATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8V8</accession>
    <name>A0A367J8V8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_001102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001886">
        <property type="protein sequence ID" value="RCH86350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8V8"/>
    <dbReference type="STRING" id="86630.A0A367J8V8"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF550">
        <property type="entry name" value="MYOSIN-IIIB ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25317" checksum="FA2B0E9E5E6881BF" modified="2018-11-07" version="1" fragment="single">MTTKPKSQFDLCDREQKTEDSLTQCLKEAFLNNVFYSKISDSAFVAVNPYKPVPLQSFQYVTEYKDTSADSLEPLPTHIYKLTNQAYLHMRRTGIDQSIILSGESGSGKTENFKYILDHLVHLSSQKKETKLQSQISNAQIVLESFGNARTGLNDNASRFGKYVELQFNERGRMTGAKLLNYLLDKSRLTQCPVNEQTFHIFYQIFSGASTEEKTILQLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9W0</accession>
    <name>A0A367J9W0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRM8_1</name>
        <name evidence="11" type="synonym">TRM8</name>
        <name evidence="12" type="ORF">CU097_005271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01001814">
        <property type="protein sequence ID" value="RCH86685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9W0"/>
    <dbReference type="STRING" id="86630.A0A367J9W0"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH86685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="28980" checksum="28C8067CC4DE4285" modified="2018-11-07" version="1">MSETEAKLPRKRFYRQRAHANPFSDHQLEYPPEPSLMDWTRHYPEFYPPKEGQVQKKVEFADIGCGYGGLLIALAPLFPDTLMLGMEIRTKVEDYVYERIKALRVQKPGQYQNVSIMRMNAMKFLPNFFEKAQLSKMFFLFPDPHFKQRKHKARIISPTLLAEYAYVLRVGGILYTITDVKDLHLWMVKHLDEHPLFERLTDEECENDPCVPHVRTATEEGKKVERNQGDKFLACYRRIEDPYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBK9</accession>
    <name>A0A367JBK9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001681">
        <property type="protein sequence ID" value="RCH87320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBK9"/>
    <dbReference type="STRING" id="86630.A0A367JBK9"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008264">
        <property type="entry name" value="Beta_glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF2">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00737">
        <property type="entry name" value="GLHYDRLASE16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="183"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608264-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="488" mass="57248" checksum="379140D0EF651920" modified="2018-11-07" version="1">MSSRWINQQHQKKLGTHSAFKESLADIELRREQTIEYAEYFKNYELSLAKYQYDIEMNILQDEYESEKHSLHDMVLQAIDERRKMIKEDKEDVDIDDLFHDAYKRVSQNKRNLRKRNLERYASPSRLERRRPNRIQTLYNIHAPPNASEEEELEADFLNMKGEQSMISATRCDCGFNDPMKDTVWQDLWYMDFQDEQHSQQLYTMQDLFFANYIIPPKYNDSYPRVFRKDNVEIVNNAIQIAVTINETNSSDISCGGFGTDKHDFLYGSFRSMMKLTHVKGTVTGMFAYHPQGEIDIEMVSALQPPEAYFAVHPGITTNGRASPLTHGEWVFNFDPSEDYHEYRFDWYPNLVVFYIDDVERYRMTTNILSQPGRIMFNHWTDGNANFSQGPIKEDAYVSIKNMTFFFNSTESSLHCNSTQRACEIKDVIYSLKNNQTSLERATSSVAITTAVTTTIPTTMTSSSSRVTIRYPWLLLILLYVRYYIYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCD5</accession>
    <name>A0A367JCD5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001626">
        <property type="protein sequence ID" value="RCH87590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCD5"/>
    <dbReference type="STRING" id="86630.A0A367JCD5"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF88">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="293"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="517"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="608"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="790" mass="90361" checksum="84D822E3B91243A5" modified="2018-11-07" version="1">MLKIPSARNLALEDDRIGQRVLLPTLNNMTGTLRYIGLIDGKQGTWAGIELDAIGQGKNDGSVQGKRYFHCPLNSGIFIALNKITILTPPPPPPPPSAVPSVTPSTSTARKPTAKRSMKKSLSSTKLSSSPSTSASLFRKSSHTSSPSPTKRLIQPAGTLKRVTQTPSSSLKTSQTPSLTPKSSQTPTQPKRQSETPKRQSETPKRQSEAPKRQSETPKRQSDASVRNETPTRRQTETPVQEKRQTQIPDTTKDTPASPSPPPPAPSPSQANMVATAVAAAKAEYEEQAKKETQLLYDMLEKVQRERDQLMQEMKNKEAAWERLLSSKESLKLQIQDSESQCKRLSQELEVVKQERKQLELDLAERDASIAKNVRDDEKQSQDQRRIERLENLVRDLQAQLQTQQELQVQKEREYAGVVEQMRREMSSMEAMTASLEKECDEMRRTGIEAVHAVELKMDEQKENYEQALREKEAQIQHLNYVIADLKHKQSTLFDDDERDIEEKLRELTSMNQSDQRHRLEEQLELTMKELDNERNSIKSLLHEIEQLRLELNQSRQHALSVEQKFQSLQADFEKELQDKRRLVEESDHAFEAQTKAEDEHEQMKLSKMTIEKQYNELLEIHKQLEQDHNKLMDEMIALESQEAELGGDGYTHLKERIKRLEEENKSQRTQLSHKDDQIRKMTKDINQLEALVENKVFGDSELEEQLELEKKRVIALERELNQLKHKLLTSPNTPPTATTTLPISKLYCELCNNDGHDVLSCELSKVYCDNCDQYGVHTTEDCPNQDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCN0</accession>
    <name>A0A367JCN0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rabenosyn Rab binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001607">
        <property type="protein sequence ID" value="RCH87694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCN0"/>
    <dbReference type="STRING" id="86630.A0A367JCN0"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rabenosyn Rab binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="58" mass="6872" checksum="E68EE69F97CFAC47" modified="2018-11-07" version="1" fragment="single">PERKQLKQQLETYLEQTRLVEGFIRDAEKEGKYDDVKTLKVSLEELHGEIENLRAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE41</accession>
    <name>A0A367JE41_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001516">
        <property type="protein sequence ID" value="RCH88177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE41"/>
    <dbReference type="STRING" id="86630.A0A367JE41"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="297" mass="33285" checksum="B65DEB71C49192D0" modified="2018-11-07" version="1">MVSSSERVFILGGTGNVGSKTTRDLIAKGIPVTLYARQPEKAKASFENNSLVNIIQGDYKDLAPLKEGLKGHTRLFLLIADMYNMIHLKKTIAAWAYEAGIKQIVDISSFTVSCPLRTTFIGVNHYESEQAIYHLPNRGAYVALRPGRFMSNIFMFDGLQFSKDIIFDTVDADKPQGWVSPNDIGAVAAVVLSEDIEKHGDSVYELNSDVATPAQRVAYLSRILGREIKYKQVNSLEKYDMLMSTGHLSHPFAYCLSTNLASYDMQNPTITDGIHVLLRRKPETLEKYLEDNKHLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHF7</accession>
    <name>A0A367JHF7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA ligase (ATP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LIG4_1</name>
        <name evidence="4" type="ORF">CU097_002358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001312">
        <property type="protein sequence ID" value="RCH89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHF7"/>
    <dbReference type="STRING" id="86630.A0A367JHF7"/>
    <dbReference type="OrthoDB" id="2283618at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="117"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="339"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="47804" checksum="792A24D611AC9C6F" modified="2018-11-07" version="1">MVKMPFARYEMKKTNAWLKLKPDYMDALVENCNLLVVGAKYGTGRRSNKLAQFFCAVRDDTIPETEEPSLISHLMITTSIVESSQWGMQCALRFPRFVRSFALVDTQRGLDSSNISKKTAIFEALKIFIASGNEEYSKQELEKLAIENGAECVQNADASDIVIAGSTNFHVLSLISSRKYNILSFQYFLDCVNEKDLLDIEPRYTIYITDVARQEVMEYIDDWGDSYTKLVSEERLAEVLLYIDCQTMCLCVLCKKVLKKMTLDNRKEEYYRKLVSEHAERYFDDHIPGMLFFKVIAYFDQDTKMSLTRLGNPLTADWIKKKKSWDRLELLSIRFKSEGGLIREIPTGDVTHVVFNKQDLCRLEELTKTFRRERLPRFVTSEWIEACLENDTLVDEAAFEPKIPAALLQKGMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHJ9</accession>
    <name>A0A367JHJ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_002581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001289">
        <property type="protein sequence ID" value="RCH89428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHJ9"/>
    <dbReference type="STRING" id="86630.A0A367JHJ9"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50298" checksum="948025355BA3BB82" modified="2018-11-07" version="1">MTDSMYTLGLSRSWNTIEPAWSSFKGNDPDNVTAPLSFFAATHVPISDYFFIDGGTWASSSLKGEQLARRYTIEREREKSKKIMINIFFFLSFRKQHTAISDNEGRVWLWGGVSDVSTYGGPPIYYNTWTVIDTNTWTISRPSVENNPPPRIDHTATIISNKYILITGGVMYSHDVANPADNLTLNPVSMSSLLLFDIQNNRWHNVTAGGNIPAPRRGHSAVLSLDGRKIIIFGGGATDGRSTQFNDVFILELSTMQWTAPAIEGIPPKPRKYHKSIMVGNYLLVMFGIGDGDTGFDDVNLLSTTTWTWVNQYTPNPAWLSGNDSNSLNSSNSGLDPFYDPNYGSSNDETTHKVDPDSRIKAGITAGAVSGSVVIIGGGLFLIVSIVLLKKRKKRELMDKSSIGSSNDPGTMHQENNSTLSNHAHESHEFQKPDNRSSAGYAIQINEGELYKPDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHN8</accession>
    <name>A0A367JHN8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADE13</name>
        <name evidence="14" type="ORF">CU097_009969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="PJQL01001297">
        <property type="protein sequence ID" value="RCH89389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHN8"/>
    <dbReference type="STRING" id="86630.A0A367JHN8"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="371"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH89389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="480" mass="54625" checksum="087F55C3550F3815" modified="2018-11-07" version="1">MSHDKYQSPLVSRYASKEMAYNFSEDKRYSTWRKLWLNLAIAEKQLGLNDITDEAIEQMKANIYNIDYKVAAEEEKRRRHDVMAHVHAFGLVAPAAAPIIHLGATSCYVTDNGDLIILRDAYDIVINKLVHVIDKLSKFAEQYRALPTLGFTHFQPAQLVTVGKRATLWIQELLWDLRNFERARNDLKLRGVKGTTGTQASFMALFNGDHEKVEQLDQLVVELSGFKEAYPVCGQTYSRKIDIDVLHPLSGFGATAHKIATDIRLLANLKEVEEPFEKDQIGSSAMAYKRNPMRSERICSLSRHLMILVNDALQTSAVQWFERTLDDSANRRISLPEAFLTTDIILTTLQNVCEGMVVYPKVIERRIQQELPFMATENIIMAMVKKGGDRQECHEQIRVLSHQAAHVVKMEGGENDLIERIKKTEYFKPIWEELPALLDPSTFIGRAPEQVDSFLLKHVKPALAPYADVLKEESKAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JID4</accession>
    <name>A0A367JID4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger CCHC domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001239">
        <property type="protein sequence ID" value="RCH89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JID4"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24900" checksum="6A302AB8C6A30164" modified="2018-11-07" version="1">MWRTGPRYQGLGSQPSSASVQCQKCLERGHWTYQCKKDRSYRSRPSRTQQLKKPLKLYQPELPKELQDKKGLADKILKKKKKERRRRGSSESSSDSSSESDSGSESDSGSSTVSTSSSYSSSSSSRSRSSSSGSEMVAAVVVEAQVLIVEVVSAHRAVPVEALQGTEEGEEALVHILNDAEEVNSRGRSISRGRSVDRRRLRSHSRDRSLRALVEAQESAHMKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJH9</accession>
    <name>A0A367JJH9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DDX20_2</name>
        <name evidence="14" type="ORF">CU097_011650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001179">
        <property type="protein sequence ID" value="RCH90087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJH9"/>
    <dbReference type="STRING" id="86630.A0A367JJH9"/>
    <dbReference type="OrthoDB" id="434041at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="250"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="472" mass="53581" checksum="1B1FE1FBA5AE76EC" modified="2018-11-07" version="1">MKRSKDVEIEEHVDFSTLLQNKQLLQGLQQSGYEKPSPIQLKAIPLGRLGIDLIAQAKSGTGKTVVFGVLAIECVNLSVRQPQVLIVAPTREISVQIRDVIRALGQFIPLQVEAFIGGLSVEADIKKVNHCHIIVGTPGRLLALLQDKKIDLSHLKLWVLDEADKLLTKEFTPQTEKIFSHLPKSIQHIAFSATFTDQLLNDLNAFMNSPQQIRLTEGVPTLDEVRQYYVDIQSSEPTSKLSIYRSKFETVAELLRKTPFYQCMIFVNSMPRSIELAEWLSEMGWKSAHISSGLSQHERLAVMDKMRQFKLRVLVCSDLIARGIDIDRVNLVINLDLPWEVETYLHRVGRTGRYGTSGIAINLVGPEDMPHFEEIKKKGIQVLPLPGNVTYGEYQKELTAEEQAVLKEHESVNIQVKPFRSKRISKERSVETKKAKTREKHKPTLLPTSKDKSRTVKSQSYWQPFIPPDLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLL7</accession>
    <name>A0A367JLL7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001059">
        <property type="protein sequence ID" value="RCH90844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLL7"/>
    <dbReference type="STRING" id="86630.A0A367JLL7"/>
    <dbReference type="OrthoDB" id="2273669at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="350" mass="39385" checksum="2CFA09BAED62FAAE" modified="2018-11-07" version="1">MAYSEYSDYSESEDEYAPLQMSGWGTQKVTEEGKTEVNVSMDDWASLIDPSVKLKSNGIGTGQLHRQGKNFKPVDEQLILDRRLGKPLPKGGLNGGKKKKKSKPGQPPPPPPQQQQQQQQQQQQQKQQQKAPKPSKPSKPLSVAPRRPPVKAGSNAWTTDKLMETPFWNNPNGTSASKYAPSQPSQPSQHQQPQQQLTQTRRQQSHSQPQQQQHWNQQQQQQQQQQPQTPSWSQPQTQQVPSWQQQQQQPLGTMASKYATATPSQSPVQTQPLQYQQQQHYTPPAAPKTPCLTFKIELAPGVTANLPVYPNDNPSDVVSQFEKNHHLVMSDAAKARFAERVAMLLSQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN07</accession>
    <name>A0A367JN07_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PBS2</name>
        <name evidence="15" type="ORF">CU097_007644</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000994">
        <property type="protein sequence ID" value="RCH91275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN07"/>
    <dbReference type="STRING" id="86630.A0A367JN07"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000432">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="131"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH91275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="44742" checksum="A87A517B2179A6B6" modified="2018-11-07" version="1">MATEPVVEENTSNTAPIPRPMPPRIPGRSVLPPMSRSVPLQQNKRSPLPPMSGASPAGGLRGRPGSGRMGKPGLNLSQLGLSPKQEQTPFANFSKYVDPSGKLNFAGKAIIHADGVDFSNGNSFTIKMDDLILEEELGKGQYGTVRKVKHRVTNVTMAMKEIRLELDETKLHQILMELDILHKSSGEYIVEFYGAFFIESCVYYCMEYMDAGSLDKLYGDGVPEEVLAKIAISMVEGLKFLKDELSIIHRDVKPTNVLANRQGQVKLCDFGVSGQLEKSLAKTNIGCQSYMAPERIKAANTYSVSSDVWSLGISLVEMAIGRYPYKYDNMFAQLKAIIDDEPPALPSETFSTEACDFVAACLQKDPNKRPSYADLLEHPFIKKYEAVDVDMAKWAQDAFEARVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNV4</accession>
    <name>A0A367JNV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000975">
        <property type="protein sequence ID" value="RCH91391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNV4"/>
    <dbReference type="STRING" id="86630.A0A367JNV4"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="91881" checksum="D91C9643EDEA5077" modified="2018-11-07" version="1">MTEKSKVKVAVIGSGLAGLSIAYLLTKGSDKFEVHLFEKNASLGMDASSISVGPNKEHRIDVPMRSFMSGYYSHLLRLYNHLQIPAKKAKFSFGWYKIQQDTTQQYAPTEVASFTKNEPYLIYSGARTVGYLNWIQRNTHSLMDSVQAFVTFFWNTCIVAFSYFQILLISLYMHHKGHLKDPMHEICNLTLSEFFKRYYIHEYFAYQVFVPLFAAVCTNSHQSMLQYPASDILEYVALGVFEESYVAACGVQQVVKRLSAPLEHIHLKTQITSIKSDPSSRHRYQIQDEKKQSYDIDHIVFATQGNQAADLLKHLAHSTPELKESLKDQIDMLSRFRYDSALVINHTDVRVLPRNPSHWRALNLAVIDKSVDPGDSELIVPYPHDTTMATHILNMTHNQMPQEMIYMQTTNPCLSVDPEKVLSVAWFERATVTLDSKRALQTGLFTLEDGEYELGPCQGKNNIWFVGSYCWKGIPLLEGCVASAEYVAIKGIARYEGVSVNMPCCLIVLSLASSGDIQPEYRLCVDTCSSKPHLLPAYLRLFGWTVRDDCRYRCMQSITQEAIEQGTRIHQYHGKWPFYRLYGIQEPASVLFSILNGLQHYKYFFRLKQQLSNTYYLKPIYMGISICGMNAWIWSTVFHSRDTSWTEKLDYFSAGLYILYGLFVAVLRIFHIRHRLAIAVWACLCAGAFTAHVTYLARLPRFDYGYNMLACLIIGGIQTSLWLIWSIWNVKKRSYAWMAGVSVVLVSLAMCLEVFDFPPWLGTLDAHSLWHAATIPLAPLFYRFLLRDAYAETNQTSVNKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQW6</accession>
    <name>A0A367JQW6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000843">
        <property type="protein sequence ID" value="RCH92337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQW6"/>
    <dbReference type="STRING" id="86630.A0A367JQW6"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017082630" evidence="1">
        <location>
            <begin position="21"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="331" mass="36990" checksum="3C51FF12713F3124" modified="2018-11-07" version="1">MFLNKWTLLILVTGYLLASSQPPIIRGSLSDKPSDLYPPDFYPNGTYLTLPHGTMRYWMFGNEQGNPVILIHGITTGSSCYDKLARELANSGHHVVVYDLWGRGYSDAPHAYYDEALYTSQLALLMHKIGWTRADVIGVSLGGGIATSFTAFYPEMVRKLVLIAPTGLMQQNDLPLTSKVARLPILSQVLIGQPLVRPLVTMAIRHFAASARHANANTEEGSTELADRISQIAYHQFVHHPGFFRAFLRTVIDFPFTGLKERYERVGQLKGVNSTLLIWGDQDKTVPFHNHVQVHSSLPHAQLVVFNNQGHDVLITSWKSVNAKVKDFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR72</accession>
    <name>A0A367JR72_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000825">
        <property type="protein sequence ID" value="RCH92450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR72"/>
    <dbReference type="STRING" id="86630.A0A367JR72"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43650" checksum="A7872E8D126FF82C" modified="2018-11-07" version="1" fragment="single">YDPQWKNKRKAAASLLSPGSVDKYGEILEVEADSMMSRLTKIADEGIAINPFKQVQLASLNIILTLAVAARCNDVDDPIFLGINSYIHQAMIYAGAAGDLGSFVPSLAWAERLRGTEKKLREFVETKRDPIYGMLIQEALKKEQDSLAKAMYEMKEQGLVDEDDIHVFMSDLIGAGADTVAVSLYWTFAILAQKPDVQKKIIDELEAWKAKNPAGAIPNFHKDREEFPYAICVQKEVMRFRPVTNFGVPHMASEDVIVNNYLIPKGSILVSSMAAMHMNEKFYENPTEFKPERFMSNTSRMGIAANTKIEDRDQFGFGWGRRICPGIHLAEVELFNFYVRFFDRFIIEPELDAQGKPVPIDLDDYSDEGIIVKPAPYKVRIVHRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRH4</accession>
    <name>A0A367JRH4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000813">
        <property type="protein sequence ID" value="RCH92543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRH4"/>
    <dbReference type="STRING" id="86630.A0A367JRH4"/>
    <dbReference type="OrthoDB" id="2399720at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="678" mass="76071" checksum="0EE035BE84741F1C" modified="2018-11-07" version="1">MTSDSPRLFNATSPSKKFATSLNATGRSSHARQRMLSSKISAPLPINLPSLKSEHGGVNGNGHATEAPTSSPSISWEATHPDTRAWAAIPTPSIHPTTPSSTPFETDPKPKQDKPMIEKHAASEMGRLSWDEMVNEDMEEFSVDVIEFEDGAKFPVNDVSPETRFSEDYDRSYPPQLKSTLQEESPKKSTYEGRPFDRRQSSGSWNRRPSKPSAYSVLQKTKLPDQKDAMVAAVERAQRRHEEQEAAFEAARQRARQKAESLATKSKEERTLTEDEKNWTNYAENMRASKSMPSRRPNGDTSWNDYAVRLHQSFVHKEEQKKTVSIAAPPRRSSHGMSPEQEFQRRRSSSFVRRASSPDHGSQEKPAVGLQRRGSSPSHPGAPLSGAFSSLDKKIGPQHTFTRHSMHPKSPIEDTNQFSILEAEDKEPDHRDEWLDMSEPEEVYDWSELAPKDESPSKFSIGKSGLPLWLEKRGPTPHWTFNDPILPFDVRYPLYWMPNDSASSLDARHPLSGGRGRGKPDTRAQRQMPVVTSILRKASEPTSAVAPSILPRKPMTATNPSLEKENQDDVKEEPHERTYKDKIMELFQKSTGSPILPKNLQAKTNLGGGINFMAVHTEEKKDTQPSYPSSHVPVLVYRFPDQKGKKNNLTGIYLMPIKSTSSVHPLSAEFPLPRTMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRT6</accession>
    <name>A0A367JRT6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000798">
        <property type="protein sequence ID" value="RCH92657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRT6"/>
    <dbReference type="STRING" id="86630.A0A367JRT6"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="265" mass="30194" checksum="F651798ACC2601EC" modified="2018-11-07" version="1">MKPAISFDNAIQLIMADYWVSQQKHWCKYCKKFVANNKPSISLHENGTAHKAQVERFLRNVYKKGREEKEQQESVRKELQRIEQAALLSISMKDGPKHLSSSSSTSSITTTNKPSSSRVSRTSTSTGAYGYGANYYVPTIEELRNPTVKEQKVEGREEWAVSKDVAKVGEWEVVTPVTPPTSEPGTTKRDDQQQQRSTHDQAPEFQDDDEGTNEEDLNAFKLKEKEYPTNAFSIDDSTEQVVFKKRKLADSSISRKKKPLRKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS79</accession>
    <name>A0A367JS79_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II core subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPB11_2</name>
        <name evidence="8" type="synonym">RPB11_1</name>
        <name evidence="8" type="ORF">CU097_005079</name>
        <name evidence="7" type="ORF">CU097_012967</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000776">
        <property type="protein sequence ID" value="RCH92814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000696">
        <property type="protein sequence ID" value="RCH93449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS79"/>
    <dbReference type="STRING" id="86630.A0A367JS79"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH92814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16255" checksum="A55C8E1782D0643F" modified="2018-11-07" version="1">MNAPDRFELFVIPEGKKKVEMEVDTKIPNAATFTIEREDHTLGNMLRGQLLKDPRVLFAGYKVPHPLEHNFVIKVQTVPGTSPGKALKDATTELISEINALKNKFDMEVIRHRTFEDAKASQSNYGGVDSMNAMESHHAGMDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTD8</accession>
    <name>A0A367JTD8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000738">
        <property type="protein sequence ID" value="RCH93119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTD8"/>
    <dbReference type="STRING" id="86630.A0A367JTD8"/>
    <dbReference type="OrthoDB" id="2287180at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="354" mass="39320" checksum="A604F16CF52B7B83" modified="2018-11-07" version="1">MSTLEKSPLLPYTEQDGPCRRQDCQKKLRRAKRWSFFSAFAVLAMFLMFSHCDKRHHGESRMMALHAGNVDTLSACPLEPSIPYEGIHDFNFKPEQYPNLEIKYEIREHVKPLNIKRGTTVVVEDKDASDVSVGIDVKLSDDELQAIFFINQTTFSDKFIINLGNDEPTSNQGCATINIIIRVPHASALKGLDIGLINSDYTFDKEGLVFEHLQLNVVSGNFNLQKGFTSGSTKIAGINSNVQSSIYSLSGDLSVTVINGHINTNVNEITTSAKTLKLDAINGAIDVQLPTDFESQFKLDNMNGRRTVESSNPDQLHITKRSFGKLEGYNGHDSAHHSVSLSTLNGPLSLKYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTS2</accession>
    <name>A0A367JTS2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000721">
        <property type="protein sequence ID" value="RCH93249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTS2"/>
    <dbReference type="STRING" id="86630.A0A367JTS2"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="510" mass="55848" checksum="BED6A3282C690A03" modified="2018-11-07" version="1">MDSRDLFMPKYMMYCGIVAAIGAFSNGWTIGSTNVPGQVTHACPTGDSHTYNPSFPDCLPMSTSLWGFSVSSFCLGGLFGSLVGGAIQTKLGRRMTIIVNNIGFITGGILIGCSVHTAMFIIGRILCGISCGLGSLVIPTYLGEISTVKGRGLMGSLNQFFVVTGILLSSIIGLPTANVPFWRLNYAIVAIPAIFQIFAMFTCVESPRYLISIGRVEDALIALQKLRGTADVTEEFFDIVAGQLGKKKAARILKENSHEKNNLKNINMDEGFDNNDSADESGQKIPKDVEADDDDERRPPMSLVEIFKDPVIRKILGIVLFHHMYQQLSGMNAVMYYSTSIFESAVDHQNAQYFAIYTTLVNFGMSIVAMFFVDRSGRRMLLLLAEFGTFLFSVLLVIGYRYSIPNLLVASVFCYVASFAIGIGPVPWMITSELTPIYASSAVGSVCTAMNWAMNFLIGQVFPVIFAAIAGWSFLIFAVICAIAFIFTFFCLPETKGRSIEEIVASFHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU97</accession>
    <name>A0A367JU97_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000683">
        <property type="protein sequence ID" value="RCH93552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU97"/>
    <dbReference type="OrthoDB" id="2281363at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17565" checksum="4D3F5A030CA76510" modified="2018-11-07" version="1">MKIADMLNPTSVDQLVSPPPSPQQKVNNVKQSINASGKSRSRFSNEEDAIICEGVARGLTWGQISHQLPHRKRATCFNRYRTLQGIRKSRKRYNDMGSSSMTSSTSSWLPSPPLSSNHLKHYHQQQEHQKQRHQQSPTLVAPLPLHYAYVDRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV04</accession>
    <name>A0A367JV04_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000654">
        <property type="protein sequence ID" value="RCH93804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV04"/>
    <dbReference type="OrthoDB" id="2229438at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="91" mass="10846" checksum="DEF0456EA23C1693" modified="2018-11-07" version="1">MPTVHIQTPSMPSAKHNLFWSIKRLFMHKGSHLDMKKIMHKNDAAERRHHLESIRRRAQQIKLEYLILSHKTAELEKRSNQTEIIHPAMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV21</accession>
    <name>A0A367JV21_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apoptogenic protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000652">
        <property type="protein sequence ID" value="RCH93824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV21"/>
    <dbReference type="OrthoDB" id="6246201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="20351" checksum="4CE842C15A366D2D" modified="2018-11-07" version="1" fragment="single">YSLRSTVSTRTLTTVCTKKIKKRPIEDLSKPVAADMIGTPDPISNLRPVKYYIPPDETKEEREWRESCQRVDEFNQNFWYKNNLMFAEAKAEYEEQLRKSGQEVTAEAMSVFYKDFLNKAYDRQMEYNRNWWKMNIAQLYPGLKAAIRSMRKTRQTEIDRGTGFWEKSFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV58</accession>
    <name>A0A367JV58_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Assembly chaperone of rpl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000683">
        <property type="protein sequence ID" value="RCH93551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV58"/>
    <dbReference type="STRING" id="86630.A0A367JV58"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38109" checksum="A0901F287D3DA2BF" modified="2018-11-07" version="1">MSYTVDDLKAKITENIDKLDYPAALLFCQKGLQLEPRNAELLEMTAQVELELEQFEAAHKHLLQSIEAAPNEGYSKYMYLGQMLSEKDAIQAFQKGVDLMVIEKSKIQDTTSEEAKFLASKISSALCSMTEIYLTDCCFEPEAESKCEEYLSQAQQVDPENPEVYQLLASVRLSQQRNEEAAAALNKSMELWIDKEPGDAAIPIYDTRLALVKLLLEVGMFEHAFTVLENLQKENDEVVDLWYLYGWTYYCLGDEEERTEEERITLWSDARDCLETAVKLFQVIGSDDVAMFEHSKELIQTINQVVPETVEEPEEEVNEELEIESEDEDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV96</accession>
    <name>A0A367JV96_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000647">
        <property type="protein sequence ID" value="RCH93863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV96"/>
    <dbReference type="STRING" id="86630.A0A367JV96"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="579" mass="64746" checksum="3E7EDCECF3765578" modified="2018-11-07" version="1" fragment="single">STSHGVTNFLTRRHSTGDGNLSNTFILPSYPPSTPGHDCREFNAPEGTYSLAHSIFISSLQPLYTVGTSASLVSIKYKESTTNLQRYEAHPGAMNFRRMFSSSSSNSNGHNIHSTSNNIDSDDEQHVFGTTPSSSSSSCNNNHTSKHHIMPIPEDETSSTTKLSFLSRNHSRQHHSRKPKTSITKTNSSFVQKIITNDQLAKILMSRTSDDTNLFYNCGTSFIWMDASGNPKEPLSRTVFTRACPTSHDVNLLTRAADQLDLIIGFTSGDIIWFDPLCNKYGRINKGGIMNSTSITMIKWLQGYDNLFMASFQDGSIMIFDKDKEDELFHPDPVPNVKDKKLFKISKHPSKIASKCNPVSHWKLSYQSITAFAFSPDCQHVAIVGLDGLLRIVNILHESLNDVYESYYGGLFCVAWSPDGRYIITGGQDDLVTIWAFKEQRIIARCQGHHSWVRGVAFDPWRCDEKVYRFASVGEDAKLILWDFSVSALHKPKTKAGNRNRGTSVSSVNSPPLSSILATIQDKGPVIHPVLSKTEVAFLQPTVIRTIHSDPCVGIYFREDAIVTTDKRGRINIWQRPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVM5</accession>
    <name>A0A367JVM5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000636">
        <property type="protein sequence ID" value="RCH93955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVM5"/>
    <dbReference type="STRING" id="86630.A0A367JVM5"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11357" checksum="90F041E30F4AF352" modified="2018-11-07" version="1">MLSNFVRSTLIRRALYSTQADALEGLSAGEKHIYTKLSEALTPHKLQVTDVSGGCGSMYAINIASKKFEGMSIVKQHRMVNEVLKEEIKGMHGLQVYINIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVZ9</accession>
    <name>A0A367JVZ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000621">
        <property type="protein sequence ID" value="RCH94077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVZ9"/>
    <dbReference type="STRING" id="86630.A0A367JVZ9"/>
    <dbReference type="OrthoDB" id="2287306at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="282" mass="32784" checksum="5C2F07134CD154FF" modified="2018-11-07" version="1">MKNCMPTLPVSKVSLNNGPFKILSVLRHILEKYENLNMAQSSQDAKDSVSWRFININAQNLTGIFSEAKQEKQINESPFDHNRRQFFQMFDFEKLGFRSREELNNMPEQTGSMFLSGMYTDGYTCRVLFCRKVLPLPAANDVSLEPSSFTTDEVDKYFRPCTVDPGRKDAFVSYHGGTDVRRLFSAEYYNMDGTIKRQKVQQGRKKKLRRKNKTRFEEGDRKRMPLIIFGDGLRNKDHITFKGIRHGVSNKIYRQLKRREGLGELLLLDINEYKTSKPVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW72</accession>
    <name>A0A367JW72_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000607">
        <property type="protein sequence ID" value="RCH94186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW72"/>
    <dbReference type="OrthoDB" id="2272203at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="177" mass="20478" checksum="D3CB5615FF5D32C4" modified="2018-11-07" version="1">MAEIFNYPSFIKYIQHDNSVNIRYVRKSKTQEATGKRVDLLQKMMDHLRAKSLCRKVFVSPSSNANDPLIQRDEKLKPSMQATLQRLRHINGDCQDLITELQTARSPLRLIVQDFTGLSTVQDDIRLLVEKCKNHEIVVDNGYRMDSFSRASILNDNGDVLQRFVTCRKAPLRRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWI6</accession>
    <name>A0A367JWI6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000588">
        <property type="protein sequence ID" value="RCH94344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWI6"/>
    <dbReference type="STRING" id="86630.A0A367JWI6"/>
    <dbReference type="OrthoDB" id="2217005at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="37200" checksum="56E7B24555F99C5A" modified="2018-11-07" version="1">MFAPEIFEKILSNLSFAECYHLRSVCYAWMQRIDYYLYKAFKCQQKQLHIVHKQQTLASLIPYCFDEENKVIEFRPADNNPIKIQQVSYIQLHFSQWKVFDSASKQLRALDIGLRAQALFHLGYNPSREQLYEIPPPLACLNSQIRYIGDPGVIICFSYSSNNVTADPAIVLKIHSICVHLSWLLSGIDTQIVPQEIYVDRYLTLRDASRKRGVIRFNKYSEPVLTYIMANTTEALESVLSKMSTNDVPFVRQQIQTALKSFNIDPRVIWKYTFVKRYILEGQCCNEHIMQVVERIKASEEEWQKKKQDLLQQLVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWJ2</accession>
    <name>A0A367JWJ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Dicer-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DCL1_2</name>
        <name evidence="22" type="ORF">CU097_012128</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000592">
        <property type="protein sequence ID" value="RCH94303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JWJ2"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000004">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000001">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20930">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="100"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="417"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="21">
        <location>
            <begin position="617"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="18">
        <location>
            <begin position="966"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1126"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1303"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="16">
        <location>
            <begin position="1481"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="765"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCH94303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1585" mass="181731" checksum="BF6C52C5789B4184" modified="2018-11-07" version="1">MTTETLRVSDDYEDKTVTYIPLEPIENRMNEGDQSRLLKYLEPEFINATPDSKTKDLGFIELEEKEKLELDYDEDNAETAEFEAAQQAALLAPREYQYELYQKALQENVIAVLDTGAGKTLISVMLIKHMAALEKEARLSRRETKLAFFLVDRVPLVFQQASVIKANCDIVVEAICGEMDVDNWSEKRWRNIFEESDVCVMTAQIFLDALYHGFLSIDRAHLIVFDECHHATKRHPFNLIMREFYDRCPAEKRPKIFGMTASPVHSKNDVENSVAQLEKNLDAQVYTASNMEQITTFKVLEITALYNPAPIYEETELTGQIREKIGSIPKFSRCFTVARDILAQLGPWCCDVTWKYMLSGLERRVARQTQDLGRESLLEDDLALKNAHELVDNMEIPRNPNVYDISLFSPKITKLIQILQIITSGTQQFCGIVFVERRNTAVAIQLLIQSLDSLSRLRAGILTGHGSSEEGDVQMHFKEQNKTIQKFRTGEINLLIATNVAEEGLDIQPSSRFDFFHTLISYIQSRGRARCSDSKFVIMAEQKNHNQTGTIDDFRALENSMKQFCQALPADRNVANKFDVGDDGYASDEEDYDSDEDFMESAIIDLETGATVTKQNAVPLIHRYCSSLPSDSFCVLKPIFEFVTSIEGYRCILSLPSNAAISQVESPFVRSKKLAKALAALQACDELKQVDALDKHLLPRNLKKEILGEMAPQYDENGYIIGSRRRHGLYEKRTPKFWERIVETEEDFDVEHNEDLLKATRIANHGTEANEKKDVENEGSSPVKVSEMDVDGSTKDNPIIGTLSKEVSELQINNNPATENNMQVQKDKEETEEELGEGPFSMWFTVLEVEMENHQFEERSYRRLCLVTKKPFIALPQLKLFHKSKPFAVNIRNLQTELVFDRDTVVLLSDYMLKLLKELMNKEYHCPMIDIPYFIVPLVKNCEEAKFEELSADDLKNLVDWSQIQAIVDQANKPLDLSEIEDPTDIIVIDNSDHFRRYLVKTIRHDMNVLSPVPQGYNIREASYATFKDFYNELGERFTITDDQQPMIEVERFKKTMNFLYPGETMAAQLKGPARTFVVPQFCTQYFIKASVFVAMMMVPSIMTRIDSFLLCHDARSRYKLPITDEHLLEAYTMPSASMEMNYERLETLGDSLLKFIATIRLYINFPFSNEGELHHLRIRVVCNRALYRAAKRLKLYRYVTSQAFNRRYWRPPHFTCTADNPETLEQINKHRLSDKTLADIVEASLGAAYLCNGLEGCLQTAIQLQIPFDQIEKWSDFNVVFEESRKTVPPRAESKALRMLNLPKLQALVEREFKKPLLLVEALTHASLPNSTAPCYQRLEFLGDAILDFLVIKYLFTKFPDADPGTITTLKDSCVNNQILGIICLNNGLHKHIIHYSGKLVRSIETLEQEVDDMKKSGQVEGEYWRNLNIPKVLSDVVESMLGAVFVDAEFDLEPCSRLFEKWFVPLLTEHVTPELIRIHPMRKLLTYLQNFGCESFMLRNHTTGSTGSESQKCVVFLHDKPLACGADWNIKVARRHAAEKAYERLMDEPELLETVCNCRISHIKRGLLPEREIEDVDDDADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWZ6</accession>
    <name>A0A367JWZ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PEX6_2</name>
        <name evidence="12" type="ORF">CU097_011016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000576">
        <property type="protein sequence ID" value="RCH94456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWZ6"/>
    <dbReference type="STRING" id="86630.A0A367JWZ6"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="509"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="800"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1076" mass="118298" checksum="DF985644A0BCDDF4" modified="2018-11-07" version="1">MTLPINAHLKLVHNQETQWVEVSEDLWNLVSANQDSIALSVTVPSLAARTPISTRDSQPSLDSFIARCRPATEGKKGQVVYVSSQLIKSVYGSDALSRLDDDDDDEETTCRVEIRTVQLIELDEIILGALNETSYTQAQKDYNAISTLLSGKIIRSSEIYHFDHELAYKVLMTNPVRQGYIHSSERTRLFVVNISDVDDDEALGNSVSLSSVSFNTLNAQPDPVVIEPREYDVKILERKWPETRLCPPPSANEDDENRVFMKLKDLASCGIFSGDWALVSANDPKKSRLCKIYGVDDILEEGDVVYLPPTLYFNLNLPLPPESTSAAKITVTRVQDVPEHGPPVSSAVTIARVASPTSMDKALQSICLDSLKQWFEQKERIVCKGDIIAIPINEDMARLRPSEDESSFKPSTHPPTTLVYFKVIRLDTSDDTSNNTHPSYYGSGRRVVPSKTQMVQTGVEYSRVPVGSISYYYDFAEKLPLVRSSGPTYDQLYELVSSSLHFAGLNFDLSCNALFHGPRGSGKSTLVKEVAESIGVHVYEFSIYDILSDTDAKTEAYLRAKFEKAAAVAPCVMLIRHLEGLAKKSAVVESGQEPLLATVLEDCIKNVGSAHAATGYPVMIIATTGDIDTLPSSVLSCFKHEISIHAPDEKARLQILKNLLYHSPLAPDVSLSNLATQTAALLAKDLVDLVARAGVLALQRIDRGIHRETNESEEGSTEGPDMSMVTASDIRAAGVTLTAADFDGALGEARASYSDSIGAPKIPNVTWDDVGGLAHVKDDILDTIQLPLEHPELFGSGLKKRSGILLYGPPGTGKTLLAKAIATSCSLNFFSVKGPELLNMYIGESEANVRRVFQRARDAKPCVIFFDELDSVAPKRGEKGDSGGVMDRIVSQLLAELDGMSEGGEEAGVGDVFVIGATNRPDLLDPALLRPGRFDKLLYLGVSQDHESQLKIIEALTRKFRLHPDLDLRKVAERCPFHYTGADFYALCSDAMLKAMTRVAETIDAKVNKLNQEKRPDLPDPVTTQYYLSHLVTPEEITVQVQEIDFIKALEELVPSVSATELEHYSKVREKFEKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX42</accession>
    <name>A0A367JX42_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-alpha-acetyltransferase 25, NatB auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NAA25</name>
        <name evidence="2" type="ORF">CU097_010603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000564">
        <property type="protein sequence ID" value="RCH94562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX42"/>
    <dbReference type="STRING" id="86630.A0A367JX42"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="893" mass="103138" checksum="14BF700A4D6236F0" modified="2018-11-07" version="1">MTMDYATEKKLRPLYEAIDEGQNKLALQHCAKLLKKNPDWPLALKSLTLVRSGKDSEALQLCEQVKKAIPTDEPTLQAVTLALKELGKHDMIVELYENAANQQPKNEEFGNQWFMAMVRNNDYKGQQAAAVKLQRVFKNDKYLFWAIMSLALQGQNGNMLSYTLAERMMAKASEEKRLQEVEHLRLYLLILMDQKKNKEALDLLLNNELGKMALRDPEVRQIKSELLRDSKRWEEVLAESQEALEKENSDDWFSWLAYFEAVEALVVKESPEKVIEDAKKLITTTQNMVLDSKILKRGPFLAELELMYRLHKIGINQDQSLFLEKITSYFARFGSKSCAFEDIQVYISSLSQDKEKASRLIQSMKELIKPSSDMSTQVKNVYMNINIRKFERSLGLHQTSDIQQAHAVVNELWQQYQDALPLGKELEKTELQYGDEFVILASHILLDLYRQHEQSSFIIEAISLLEIALAKSIYNFRIKLMLVRLYLMIGVYKRPFEIYKTMEIKQIQFDTMIHYFTDRFIPLGCSDDIESVLVDSMQIYRGNEVETPEMLVKAYQYGTYSKIQEFIEFRRRLDTSLQHTVTQIELKRIDFIRSSFQAKYAVQYFNENDAKELKYDDKHFEAASDNRDFKVFANYNSSDQPSAEEICKPAKSTSKVWAQMYSYILNILGAVCAAKEKRDLNALVQEAEKFIAADGIKENITVQEYHLASYIIHLASALASIEANKAPEATDKINSAISIIQEQFCKVESFSENNTSWNTFHKVFNTLEAFSYTLVLIEAINRSLGLTSKEAKRKAAEAVEKDSLISCLFKLQEASKQSLQQMQVIVNAGKDLFRVQFQKKLFKEVTDSEKSVACLSLKDYQNTINNHIKMMVSSWSQSVIRLSEEIDRRLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXB3</accession>
    <name>A0A367JXB3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000563">
        <property type="protein sequence ID" value="RCH94573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXB3"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8810" checksum="10DA384BAF9260BC" modified="2018-11-07" version="1">MSENQQAKLVKLNIGGVPYLMYEVTLKKLLLFKNLLETEMQNNEKTDNGEIFVDRCGKLFEHVLRYFAKWNDEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXZ1</accession>
    <name>A0A367JXZ1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWI SNF-matrix-associated actin-dependent regulator of chromatin sub D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BAP60_1</name>
        <name evidence="3" type="ORF">CU097_006398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000539">
        <property type="protein sequence ID" value="RCH94788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXZ1"/>
    <dbReference type="STRING" id="86630.A0A367JXZ1"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="223"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="445" mass="51849" checksum="6DDE89011B47A6B3" modified="2018-11-07" version="1">MQPQQQPHMFQGDMGQHGAMPPQNMPQAGMQYRKRPSEVESLAKHIKKKRPTDKNLSPKIESFAPESKLYTELVDFEKKLDATIMRKRLDIQEALGKPTKVRRTLRLFISNTTAPADQQELKQDNAEFDLSNNNAPTWTLKIEGKLLSPDNDNSSKKVEPTPKMTTFFRSLAVELDRDPSLYPEGNTIEWQKQPNSTTEYDTIEIKRKGDINTNCRITINLFHNPQKYKLSPLLADLLDTKLDTKLQIVMGIWNYCKVHKLQDQEDKRVIRCDNRLVQLFGYPQIHFSQIPELINQHLSQPDPIVINYTIRTDKQFHASSKAYDIEVEMDSAARQKMMNIISSSQVQKEIMTYDDKIVQCVQSINNSKIKRDFLLQFSKEPVEFINKWIASQARDLEIILGESKANLEEIKQTDFYKQPWMKEAIFHYLTTKTQQRMQELLTTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY31</accession>
    <name>A0A367JY31_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CU097_007246</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000535">
        <property type="protein sequence ID" value="RCH94828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY31"/>
    <dbReference type="OrthoDB" id="5597044at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH94828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="12877" checksum="47732F56CD105D9C" modified="2018-11-07" version="1">MRNPIKPKSRTRRFVELQDDTGFTSAQFESQDPPIPWNAIGLAILLFLAGGGLLAVGILIKIGQITSEEWLSRGIPFIVLGSIMFIPGAYHLYIAYYAYYKYPGYDFSLIPDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYC7</accession>
    <name>A0A367JYC7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor synthesis protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MOCS3_1</name>
        <name evidence="8" type="ORF">CU097_008658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000523">
        <property type="protein sequence ID" value="RCH94933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYC7"/>
    <dbReference type="STRING" id="86630.A0A367JYC7"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="335"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="397" mass="43944" checksum="09612872E9A32011" modified="2018-11-07" version="1">MEDLKKENELLRKRVAELEKQLYAKAPTAFTPQQKADPFEKVDKLTNQEIYRFGRQLVTPNFAQLKLRNTSFLIVGAGGLGAPAALYLGAGGVGRLGIVDHDEVDINNLHRQVIHTEARKGMNKAVSAAVAVKAIYPDADVIPYAYTLDRTNALELIKQYDIIIDATDNITTRYLLSDAGVLAGKPVVSGSALRTDGQLTIYNYNNGPCFRCLHPIPPPAAAVGKCVDNGVVGVVPGVIGILQALEAIKVAIGSTALSDPSFLIFSAMNNPMFRTMRLRQKKKDCAICGENPTITELIDYVEFCQGEANDDVVSEHLLKREERIDVDEYDDILKNKRPHVLLDVRPKVQYDICHLPNSIHIPIDELDNKMDKVKEAMKEHKVTDKDDSGENDAKERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYE1</accession>
    <name>A0A367JYE1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000513">
        <property type="protein sequence ID" value="RCH95012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYE1"/>
    <dbReference type="STRING" id="86630.A0A367JYE1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="14"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="515" mass="57275" checksum="EEF0E4C90D3560C9" modified="2018-11-07" version="1">MGYLTKLTTNVYCIGGFAAIAGIMFGFDIGSNSGVIGTHQYLNYFNHPSDVLQGGINGALSAGCFVGALIAGYPADRFSRKYTLIAASFLFIIGSILQAASNGVAMLCAGRVINGLSVGITSMVVPLYQSEISPKEIRGRIVSVQQWSITWGIMIAFWIQYGCQYIDSTAAFRIPWAVQGVPAVILCMGMWFFPFSPRWLADKGRLDEALKVLADIHGNGDPSHPRVQLEMEEIRATIQFDKEVASHRYTDLFQPGLAYRVFLGVCLQIWQQLTGMNIIMFYAVLLFQQAGIGDTQEASLLSSGISYVVNVVMTIPAIIFVDKWGRRPTLILGALVMSIFLWAVGGVLAVNTWAVDPKDGKWYVHIDSKTQANGVVACIYLFVATFATTWGPLGWVYPAEIYPLRVRAMAVSLSTASNWLFNWVLNFVVPILMQRIHYGLYLLFAAFNFLMCLHVYFCYPETKGYTLEEMDIVFQHNPRKKIPREVLDEWVANKGIHQDNTFENSGSVSEKKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYR0</accession>
    <name>A0A367JYR0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000539">
        <property type="protein sequence ID" value="RCH94791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYR0"/>
    <dbReference type="STRING" id="86630.A0A367JYR0"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41733:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_30, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41733">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED/TRANSLATION ELONGATION FACTOR EF1B, N-TERMINAL, EUKARYOTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="300" mass="34141" checksum="2C29AC22F6484C72" modified="2018-11-07" version="1">MSGTTLKPRSMTAGARNVLRSNDSASLWNCTLSPGWTEEESEILRKALMKFGIGNWAKIIESGCLPGKTNAQMNLQLQRLLGQQSTAEFAGLHIDPKVIGAKNSKIQGPHIRRKNNCIVNTGGKLSREELRKRVASNKEEYELPEEVWKNIELPKVEDPLIILEQKRAEMKRLKEELAKVQASILKMTNAQPDRMDKLKFEVTQSPSVSTPGTPVTEDKEQIKIIDDEDEDIIIGEANREIEEEDEYEDMQTSLLDQDYALAMKLQQEDEDELAGEYDLDYSDDDDEDFNQTKKRKVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ69</accession>
    <name>A0A367JZ69_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SETD9</name>
        <name evidence="1" type="ORF">CU097_004151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000491">
        <property type="protein sequence ID" value="RCH95197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ69"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10537">
        <property type="entry name" value="SET_SETD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040415">
        <property type="entry name" value="SETD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33524">
        <property type="entry name" value="C5ORF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33524:SF2">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="243" mass="27260" checksum="9CB412CC22E85800" modified="2018-11-07" version="1">MQDSCTHATPISYPLQWFKLRGSAVNKASDVVLHSAPLDQEKAVEAVKRTFQAIDFNSLTFSVHTKKSSIPGAGLGVYLSGQRQTRGQIVCFYPGTIYLPSDPILFVSIANEYILKCVDGLYVDGKSTGLSGRIYRSVYKRENWPGAIEISDCSWMNQSRSNPLAIGQMVNNCTGTHKANVCYQEIDLPIQFPSELRKYIPNMYWNTIIDPMSYPMRVVALVTLRDVEPGEELFSTYMDLVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZL8</accession>
    <name>A0A367JZL8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000474">
        <property type="protein sequence ID" value="RCH95368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZL8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="73" mass="8314" checksum="B8ED2C0518C3AE98" modified="2018-11-07" version="1">MSDDNVMIHKRSSKLRGICENRVFRTLGDCTLINMIDVTFYQDQKLAEPASTFSMVNHSSLNLKHNSSIPDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K105</accession>
    <name>A0A367K105_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000428">
        <property type="protein sequence ID" value="RCH95825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K105"/>
    <dbReference type="STRING" id="86630.A0A367K105"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50358" checksum="AED9A48F10E89C77" modified="2018-11-07" version="1">MASQYTEESSSSIRNPLFRRSSSSQRNEPKVHVRIVPSIENPSRSLIFSIIERDLEAGKVIKIGRFTDKSSVQNHISFKSKVVSRSHCEVWLNHEGKILLKDTKSSSGTFVNHVRLSPANQESRPVEIRDGDLVQLGVDYQGGFEEIYRAVKMRFEVNRQSQAKQISYSISAFNNLRNITSNKQLQLTASSDNIQVEECCICLYALAPFQALFVAPCSHTYHFKCIRPLLDSYPGFQCPICRTYSDLDASVAMEIEEVIEKFGLRKNTHAQTQGDHCPSSSSSSSSDAEEEEEILHPLPTQAILSDPPLSTTLVACTNSLSGMMPPSSNNTTSNDIEAIMSDAEDHHRANIGTSASAAEQKQKNTKYNNNLVEKIKMAFSNDKRRSIAKKRMNSTGTTNSCSSSDEMERSETYFDLSTPTSIQHLNHTLSRQSTHHNNLSGIVEELASNASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1H6</accession>
    <name>A0A367K1H6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NPC2_3</name>
        <name evidence="10" type="ORF">CU097_004137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000411">
        <property type="protein sequence ID" value="RCH96005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1H6"/>
    <dbReference type="OrthoDB" id="2372305at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016877227" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="30087" checksum="3DAA64662FCEC592" modified="2018-11-07" version="1">MKLFLFLLLIVKISCLTHLYEKSSTLVDYCDNFSSDVLAIEHFRISPDPLVRGEKLIVDFKGNLSEQVMNGAAIDVKVKYGILQVLKQTFNFCEWAEVVNEHCPFPEGQLEIHKQLDIPKEIPSEELGERLSVDSVTKSVMDSFTFQINDSLKRVKETEELTSKVQKETESIHDMLSILKNKNEEMLTAFKQIDQLEIIVNRVKDTYNAVAKNMDQIERAISASTSTFGLGKKRSTTVQPYFPPPDHVDIYNTDELFNSLSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2A7</accession>
    <name>A0A367K2A7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000383">
        <property type="protein sequence ID" value="RCH96285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2A7"/>
    <dbReference type="OrthoDB" id="2289035at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="544" mass="61802" checksum="440BEC28C3175E5F" modified="2018-11-07" version="1">MPSPVGKDKLNDIHSANKQWIPQYNPIQLAAISNFKLAQLTFAPPDLHSLRKTAVIKNMLEYIYSNTPSDWLQQMTRWQFFTPESLEEMTQEGLEEIFAQYAQTIETFRPVKQQPNYYPPTSFYHSTMGDVNGQEEDDEENDDDGQGDELWIAEDEQASINAEEEKRKTTRSSGSSCSSIFSQPNATISAESFEARGSSPLIDKPLPASPDEKQARRKSGFNGNKNRLSWTSDTGITSSVVSQNLANEIMSLFDMDFAVDIKIDTAPKLPELPFKPKQQKRRSSYDMLNSLLPAFERIAFENSNEKANLDKTLSNNERLPQEQRQPLVIQSVPKRSSSLRHRQEHDMTKHQPMKETSSLPPPPQPPAHQEFPEKGLTRKTSLLKLASFVTGNKKGQPEFVMMHQNKSDPTANRRVESTSTLDSWSSEERISIRDKPLPEPPVENINTKKYLKTHSTKKKRKSAVVMEKTISKHKAFQSIYDEDNNNLPPKGLNRSKSAFIKLGGNKKQVRRVSSAKNLTTYKDDHGFVKRMASLMKRTTKPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2T2</accession>
    <name>A0A367K2T2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MDM34_2</name>
        <name evidence="10" type="synonym">MDM34</name>
        <name evidence="13" type="ORF">CU097_013322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34_2 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34_2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000364">
        <property type="protein sequence ID" value="RCH96487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2T2"/>
    <dbReference type="STRING" id="86630.A0A367K2T2"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH96487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="535" mass="60262" checksum="3521AF4707191B62" modified="2018-11-07" version="1">MAFKFNWPEFDAEFYKEARSQLEAALNKGNKPKNIVDYISVKELNMGTTAPELEILEIGELSTDKFRGIFKLTYCGDAYIVIQTKVQANPMHANESDLPRHTRPTVLAADQPLIVPMLLRISDLKLRGIIVLVVSKTKGITLVFKNDPLESIVVSSTFDSITSVRSFLQREIENQLRNLFQEDLPVMIHNLSLRHIQKEQEKQAKREQEEWLQTQRLQIMKKNAKNTRSVFSDPGIRRSNTMSSASVSVMNRTTTTTPGTSASANPSPTNNRKHFDALSMPDLDTPSTPTSYAPPRFLSSFSYSQDVPLSPLTNPFRRSYNRQTYSSFSDLYFMNEASGENMNQAELLSTSPETVSLEGQPFGSNKGIPVTAANLSTLNELYSSRFAALKTPPYSDFGDSQTNKVGEDECSYEDYYDESSVNSMIAAEMYADDVDAPWYITEGLETHSARDKENTLTMMPMDEDIVLNPKENTVAAKLAQLTNIHHTISPFTHTIDHFTYRSLPHTVKVDVKSKSKKKPKRRVIRLNTQSSTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K372</accession>
    <name>A0A367K372_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COX23_2</name>
        <name evidence="9" type="synonym">COX23_1</name>
        <name evidence="9" type="ORF">CU097_002917</name>
        <name evidence="10" type="ORF">CU097_013176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001441">
        <property type="protein sequence ID" value="RCH88582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000355">
        <property type="protein sequence ID" value="RCH96589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K372"/>
    <dbReference type="STRING" id="86630.A0A367K372"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="8">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="88" mass="10663" checksum="E9621868A00016BD" modified="2018-11-07" version="1">MPLSKPPPPPPKPEFGEPSTPKDFNEKFKQKPLTKYMNPCALEEKQSMKCLDDNNYEKDKCNYFFMQYRECKKKWMEERRRLRRAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Y2</accession>
    <name>A0A367K3Y2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000320">
        <property type="protein sequence ID" value="RCH96972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Y2"/>
    <dbReference type="STRING" id="86630.A0A367K3Y2"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008626">
        <property type="entry name" value="Mediator_Med15_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05397">
        <property type="entry name" value="Med15_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="404"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115301" checksum="01FDC8C3AA802BAA" modified="2018-11-07" version="1">MNQQNPNIINVTQPNQQQQQQNQQQQQQPQMLQPQQGLNLSLPNDTSNANWREELSVHDRARFVAQLGNALKHLSPNTADTDIFAAAKNYELSLYTRCTSKNQYIMAYAKKFHQIKFQLQNQTGANNSAAATSMMNDNQLLNINPLAGQQMSPLLQQQQPQSQSVSPQVQPAVQPQMQKPSPLSQQQQLPPQQQQQQQQQANINNQSQLRANMFQQGMLQARPPAQQQAPPQQNQQQQPQQQQQQPQQQPGQQNIPQQLNAQQAQMLALQRTAAQAMAAAAAAGTNPSNNNNSMINNVANMNTTAQQQIPVNMLQQLNMANANQAAMTMSPRQFQAYLTRQIALQQQQQQQSGQSTPQMTSQQQQGTSQFNNANIDPASIINLNMAQNFRTPASGQQHLTPELLMQHLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAQSQSQAQAQVLAQAQAQQQAQAKAQALAQAQAQAQAQAQAQAQAQAQAQAQAQAQQQSQQQAKPLQQPSQPVQQTQQPSVVPNVQLNAGATANPINNAATAHPSLQQRTQAAEYVRQMDEGVRNTRVRANPIENMSEQEKAAIRDSVAMIKPMYEKIDSLLPVFFALTSNVEATKRLMLMKYMFEDQLTALQQNKYVITLEHLTKLREQFSGYFSWVRNAVGAHTPVVQMNEAHSAAATPTMPPAGQIGIKRGSIDLKLPPNKKQKAGSVTGTPQQTTIDLTQTPQQQHAVVQEAPTTSAATATSTATAAVPTGAPSSEAIANANAAIATANPAGMTLSQRQAQSQMIYQAAIASGIPPQIVNLLPHRALQCSWLLQQAAQNRITTQPSPAAVPHASPSIKPQAKAPVNDVQSVKAEPTTDLKSYESAQKAANMMHLFRLQQQQQALQQQAQRQAPAPAQPIQAVTPPAPQPKMIVPSPRPTPTPGAALKMAILAGDDKYQSSMLYINDMQKDVEALFARADQPKPSNKTEPLFNGTKGTLLFEPFPLDDFEDDKEEEEKRNALKEEDVMDTWYKVGMDTDVPEMHDILTGFSFDECAAQAFIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K446</accession>
    <name>A0A367K446_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000325">
        <property type="protein sequence ID" value="RCH96916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K446"/>
    <dbReference type="STRING" id="86630.A0A367K446"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="435" mass="49893" checksum="67B25879DCAD7C5A" modified="2018-11-07" version="1">MQYDSHPLLIAEIASILCSFVDTKDLFSLALTCRVFYRFASERLWRTLNPTSLRTLRKIKNTLDNNTAYNKLVWKFKWSAREEHSLERLFFKSFLFPHLRELEFSNAATQDYIIYPMIAASSRYLRSLNLSQCYCLSSDAIKPLLHMLPNQLESLVLYGCGKMDAQMMVDIIQRHSGTLQCIRLTDINDAILDAIGQCLHLTDLGLEHCTSLSSTALTRYFRKAPQLTHLRMRDISQLTSQHLRLIADSSKSLVYFDMSECNQVNSSDGFFQLAIECTSLETLLLAYQTGVTNQAMQLFLSHCPSLRHVDVSGCRLLTDHAFLLNDNDLQLETLNVSGLDLLTSDSIHQLLSRLSRLKELCLGVTYDLDEADRILEIINHCEKKFFIDIERYYTICRINHTDTHIPTHPYPRLVHLPSTDISLPSASTWNLPSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4X3</accession>
    <name>A0A367K4X3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000288">
        <property type="protein sequence ID" value="RCH97312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4X3"/>
    <dbReference type="STRING" id="86630.A0A367K4X3"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="95"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="315"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="78458" checksum="E95E60DEF1B3E247" modified="2018-11-07" version="1">MLEVIPEIYNLITEVVEQPMLSELVHVFGSTFLIIYSFLLVTDGIYFLASLIAGFVLGGLYFNNTEGRFVIQEYQKTFHEELADTSSTERLELHYRSLTPVIDQLLDYFIRDFIANWWTPLNVYEDVQFEKITREKLNGACMQLEKILMNQDRNDIVMSTLYGVANTLIIHMRECRALEESEISIEDYVRRNPQSPFAQLLSKHEQHQQLRGLSQTLLKRALTGPEKESNLLISLLRELLATFLFGNILDILSDPDFLNCWIIDLLSDQASSETVQATVSAALETVVSEKIDDDDGFETRQDDELVSFSPGLVHFTVMDISPPQSPDHPLNKSQLTYIIQIERPANEDTVGSEGGGYVITRSYTDFESFHTILSARYIRRINKIQLRLPLDPAKSWLKTQTKKKGEEISHDLEIYLDKVVHDTELGRDPLISAFLRKERRSEVMNDDVVSFSEEYKDQVVAAYALLTDTKPLSRSRSLFSRNNSPKMETKDDTHSMTSSSSTTTEEEEQIIPPKALSSMDVELLIETTYALVIEIFNLTPSNNKAWMRRSILNILREIVRRSYTEFITEQYNDLLNAYMSPDAIMLRLNQLGQQLWPEGQWVVGEQKRPTEKRTDKDREESKRKARIMLMNRVIPSTVRQLIGDQNCNTAMDRIWARCQDPVLNRVLMLQLVERIIKPILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5C4</accession>
    <name>A0A367K5C4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PMS2</name>
        <name evidence="6" type="ORF">CU097_006066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000285">
        <property type="protein sequence ID" value="RCH97339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5C4"/>
    <dbReference type="STRING" id="86630.A0A367K5C4"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="216"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="586"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="786" mass="88570" checksum="E48A1ED8FCB7817F" modified="2018-11-07" version="1">MIISAIDKQSVHRICSGQVVLDLATAVKELVENSIDAGASCIDIKFKDYGVEGIEVSDDGSGIDPVNYETLALKHYTSKISQFEDLEKVATFGFRGEAISSLCALSQLIVITATKEQAPMGMKLEYDDNGKLKSKTPIARSTGTTVQLTNIFHSLPVRQKEFKRNCKKEYGKALAILQAYSIISCNIKISVFNQSGNKPSTKVMSTNKNRDMRDNMSNIFGSKIVSQITPFEISLESLLGQGSVEGFISRPEWGLGRSSSDRQYFYVNGRPCILPKMAKALNEIYRSFITNQYPFIVANFKIPTDVYDVNVSPDKRTIFIHEENKIAEIIMEQLKGFLEPSRSTFQTNDLTTTEEETVTTTTMPKVSLQSFALASGSHYRPKSMYDTNLGKRNYTKTTTSSETGNIKDYLLKKPRLDDEEVDELTEEYDNQSDKPPIMGNNDILQASEISSVASISSISEAVTEPDVIAIDTAQRKVSEITLINDMTQPMAVDIQEEQSATDSCQHFEQHKDIRSYEGHWKTNGRSMTVTIKDFVNIPIKEQTAPIDNRSDDFLIDASIQNVQDNNKATEALNRVIHKSDFARMKVLGQFNLGFVIASLDDQDLYIIDQHASDEKYNFETLQKTVRVDSQKLIRQVPQILDLSAAEELVVMDHLDVFKANGFDIEVLPDNEPTKRIRVLSQPVTKRAMLDKKDISEIIHLLSEHPDEMVRCSRNRAIFASMACHKAVRIGQSLTKNKMTTIIRHMGEIDQPWNCPHGRPTMRHLLSLSQLKQTRKREFSFKGTMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5V6</accession>
    <name>A0A367K5V6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">S-adenosylmethionine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_003535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000260">
        <property type="protein sequence ID" value="RCH97642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5V6"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH97642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30270" checksum="394BEE5FD530F272" modified="2018-11-07" version="1">MQTNSRKSKYQANLRQALMAGAVAGIAVDTVLYPLDTIKTRFQSKTGFRASGGFRGIYSGLLPAVVGSAPNASLFFVTYEAAKRLMGASTSSNTPFTYMIAATFGEISACTVRVPTEVIKQRMQIKQFNSTSSAITNVLRTEGILGFYRGFLPTVAREIPFTCIQFPLYEYFKTTYGVYKHQHVEPYEAALMGSLAGGIAAAITTPLDVCKTRIMLSKTAKEASLVETMRKIMIEEGPKKLWAGVGPRVMWISIGGSVFLGVYEKAVKTFAQLQLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6I5</accession>
    <name>A0A367K6I5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000276">
        <property type="protein sequence ID" value="RCH97451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6I5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="14323" checksum="C0A111039FF873AD" modified="2018-11-07" version="1">MTSMAAYQLKDLEKRTILQLRGLARDVHTSMKNDGFDANNTCVGLDDDIKNIKQKKADGMFRDVSKKRSSKNDPNTNTQLGDLDNLYGENDSENSFDDDLVHFFPSTSSPRSTMVGQINIHLIRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6I6</accession>
    <name>A0A367K6I6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRE8</name>
        <name evidence="8" type="ORF">CU097_002882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000248">
        <property type="protein sequence ID" value="RCH97787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6I6"/>
    <dbReference type="STRING" id="86630.A0A367K6I6"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="247" mass="26768" checksum="B4DCF660311D85A5" modified="2018-11-07" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVSGGVTSVGIKATNGIVIATEKKSASSLVDDSAVHKIETICANIGMVYSGMGPDFRVLVSKARKAAQAYKRVYNEEPPVRILVQEVAGVMQEYTQSGGVRPFGVSILIAGYDEVNGPALYQVDPTGSYFAWKASAIGKNMINAKTFLEKRYNEEMELEDAVHTAILTLKEGFEGQMTENSLEIGIIGKSTVGIHGGERKELPLFRKLSLGEVRDYLANIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7Y7</accession>
    <name>A0A367K7Y7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000209">
        <property type="protein sequence ID" value="RCH98287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7Y7"/>
    <dbReference type="STRING" id="86630.A0A367K7Y7"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="25913" checksum="9A043F0CA03D39C0" modified="2018-11-07" version="1">MLTHLIKKNPFVIRRSFHNIIGSWSESPSAQALIPMVIEQTGRGERSFDIFSRLLKERIICLNGPVTDNVAAVIVAQLLFLEAENPEKQISLYINSPGGSVTAGMAIYDTYIQSPVSTLCNGQACSMGSLLLTAGEAGKRFALPNASIMIHQPSGGAAGQASDIAIHAREILRVRERLNRIYQKHTGIRELETIEKMMERDYFMTAEEAVNFGLIDKVLEKRITPDSKPNDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8E7</accession>
    <name>A0A367K8E7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000196">
        <property type="protein sequence ID" value="RCH98446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8E7"/>
    <dbReference type="STRING" id="86630.A0A367K8E7"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24247" checksum="B820587E5ED2B5D8" modified="2018-11-07" version="1">MPLDLPALKSLNTKSIVLASASPRRREILSDMGIKFKVVTTLKPDENNPALYKTEADYVADTAYMKAKEVFDRCEADPDLPKADIVIGVDTVVVKNGKVFEKPSNADKAKEMLQEFSGSTHSVLSGVQIIYKLKDGKVEKLGFVEKTDVTFSSLNDETINIFVIHLDVNSGEPFDKAGGYGIQGEASIFVKSIQGDYWNVVGLPKNRLFEELVKIVDICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8U9</accession>
    <name>A0A367K8U9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000181">
        <property type="protein sequence ID" value="RCH98644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8U9"/>
    <dbReference type="STRING" id="86630.A0A367K8U9"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="374"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="553" mass="62848" checksum="F04AA66FD18FC9B1" modified="2018-11-07" version="1">MEHEHHIKITVPESAQDLRVRKFIVQNYRHVFKSKENIHRAFNRKEISINGCPTEETRRLNAGDIIEINYNKSIEEAERLETIPIDILYQDEHLAVVWKPPGQNSAVFEKAIHHNTAEIDSKGNKQKIWCINDIQKAASGLILVAKSERVKELLMESYMNDKINFTMRVICHGRIDTTVISDLFCLDQSDKAQESKVNPKDVLKSIDIISATRSNHAQYITTLDLHLRSPLSSLQLRKLFFFQSKHPIIGESAYTKLLHVNKDKGLYASIIHVSFLHPIKGTQVQVTGNEPQKFAMMREREFKFYQKKIERENEAMKKAGIDVSEQMDRENGQLLAYVLGQKDFFNLTFKVTKDCLIPRPASETLVKAAIDFIKDRNGIRLIDIGTGCGNLVISIMANLPSSAITSAVAIDISDAALAVAKENGEAILGKDRSKRIEWRNQSMSDVADGKVYDILVCNPPYLDYNQISKRKVQMADLGQEPHTALFAEDGGFKWYNVLSEIAPNIVKDEGRVILECGKGILQQVLDIWAGWEQEAIYKDVQGWDRCIVLKRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K952</accession>
    <name>A0A367K952_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000173">
        <property type="protein sequence ID" value="RCH98763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K952"/>
    <dbReference type="OrthoDB" id="2253208at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="113" mass="12923" checksum="FCC51ADD5B9418BE" modified="2018-11-07" version="1">MQTPERIVSPNTPIIDGENLQLILKKTDLCFSSNNTLASEETLQEYTEINNNHDNSTSIKSISGAMEIISLDSTDFDEKITALAYQKNLFNKFIKFYRVYVDHTSFNSLFIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9Z7</accession>
    <name>A0A367K9Z7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000155">
        <property type="protein sequence ID" value="RCH98986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9Z7"/>
    <dbReference type="OrthoDB" id="2250876at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9370" checksum="23D51BAE7266C249" modified="2018-11-07" version="1">MAAVVISQERMFSCKQLALIALSVENKTYVYPQCKEILEFSSINDMIIIFGNLALENILLGTAGKTTLPLKELNNKAAKGFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAJ9</accession>
    <name>A0A367KAJ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000140">
        <property type="protein sequence ID" value="RCH99187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAJ9"/>
    <dbReference type="STRING" id="86630.A0A367KAJ9"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="392" mass="45102" checksum="214927C5CA8A7542" modified="2018-11-07" version="1" fragment="single">MDHHKDYKYQASRHHDDRQSMLMSQPMIHSEVSDTYYPNYTMPHLNDYDQYPSFEEFEIIIQDYLKNLSSKKRDKALIDRNRYVMILQVLKDPRNTAISTAQFRFWVKKMFQLHAKQVVCHDGKPVATREEIYGILVHAHREAHHGGRDKTSALVRRRYSWIPKELIARFVRHCPFCIARRNGNQQNSLPFDTYYDSGSPTYQSMHALPKEQPKCMMDAHELYAQKNNVPYSNDVAFLAHTEKDQRRCSLKDQSPISVDAPWQHQDYYNICHYEGSTGNPPINAPSSPTAVEATTTTTTALFNDNGSGGYYSHDNAAGPSFSYMTYSHQVPSSVEPLPAAAMQTVIPAYYMHENGLKQNSGYSLTDNSTNFIYAAHPSARNYDVYYHVNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAV9</accession>
    <name>A0A367KAV9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000128">
        <property type="protein sequence ID" value="RCH99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAV9"/>
    <dbReference type="STRING" id="86630.A0A367KAV9"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="309" mass="35534" checksum="CF514A1620A3DBD2" modified="2018-11-07" version="1">MLLSPEERASRIRSYIEDQRTYAPYYEPPDEIPVSIVINDDNDVIDCNSLLMTSVSQVDVNQTSTTRNRSNQTSIERENDKKRKDMNHELKKPYVISIKPNGLRLLEKFTSPNIEIDRITIKSRNRNKPPSLGLFNKGKSSAKGKPNRGVPDLVFSEAEFLKKQTKEDQISVHSSSVTKRKPRRTEKKSRFFKKQDNKRDERATFGQKQQPCAEDDNSSCGCCEILSDYDDNENGAILSEDNCGLLYSNSYCSYSQIPSYSYVRSPSILPITTGYQSIDWQIEDNQDDDSDALTLKRDQLDTFWIKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCE3</accession>
    <name>A0A367KCE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000096">
        <property type="protein sequence ID" value="RCH99846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCE3"/>
    <dbReference type="STRING" id="86630.A0A367KCE3"/>
    <dbReference type="OrthoDB" id="2273669at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="317" mass="35125" checksum="A2CB52F28FF5A87E" modified="2018-11-07" version="1">MSYSEYSDYSGTESDEEYAPLQIAGWGTQKINKEGTTEVSVSMDGWASLIDPTVQIKSNGIGTGQLHRQGRNFKPIDEQLILDQRLGKPLPKGGLNGEKKKKKKKKSKSGQSPPPPQQQQQQSRAPKPLKFAPNRGRPPIQPGSSAWATDKLVETPFWEQPNGTSASKYATPSVQPPQQQPPPQQPPQQPPQRQLGQQPPQQQWGQQSQHQSQQQPLGTMASKYATPVPAQPSTPAQTCQYQQQQQLFMPADPVKTPCLTFKIELAPGVTANLPVYANDNPLDVVNQFEKNHQLVMTEAAKSRFAERVAMLLSQYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCH7</accession>
    <name>A0A367KCH7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CLA4_3</name>
        <name evidence="16" type="ORF">CU097_015473</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000117">
        <property type="protein sequence ID" value="RCH99531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCH7"/>
    <dbReference type="STRING" id="86630.A0A367KCH7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="341"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH99531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="611" mass="69233" checksum="53BEA1477D2BD7FC" modified="2018-11-07" version="1">MTEIKKDGYLQVKEDGLRAWIWSKRYVVLREQTITFHRNEQTGQCVALVFLKEITAVTRLELKPYCFELGTKSKSYYIACKNDEELYSWMDEIYNRSLLGASGPTNFVHKVHVGFDPITGDFTGLPDQWNALLKGSKITPEDAAKNPQAVLEALEFYTEQTRLDNKSEWKNDNLISSKSTPAPGHIRQPPPKPNSSKKVSPDPFSNGIVVETNKLDGTNKSKLLDTSGSLPRKHSNNNTSRMLKMSDERNLRFEREKEKLKEVAAALDRDRNLMRCLGQPLKPPIPQHQASTPVRSNRSSLTLVDKSAQKKKEQRISTMSDTQILEKLRSVVNAGDPNSLYIRSKRIGQGASGSVYLAYHMSTDTKVAIKRMDLSKQSRLDLIVNEIMIMKESHHKNIVNFLNAYLVQNDLWVVMEYMEGGPLTDVIENNTMTEQQIATVCYETAKGLEHLHSQKIIHRDIKSDNVLLNFQGQVKISDFGYCAKLTDQKNKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPALKSPEKLSAELRNYLAVCLCVDVKSRATAAELLQHEFLKKAGPVEIILPSLLKFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD45</accession>
    <name>A0A367KD45_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UBE2W_1</name>
        <name evidence="3" type="ORF">CU097_014315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000085">
        <property type="protein sequence ID" value="RCI00020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD45"/>
    <dbReference type="STRING" id="86630.A0A367KD45"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="17096" checksum="FDB87D62027E75E1" modified="2018-11-07" version="1">MTSLYSKRLTKELRDLQKNPPEGVEVEEASNFLKWTLCLTGARGSVYEGEKFKLEFRFTPQYPLEAPEVVFIRPYVPIHPHVNRCILNMNTTTDETEYIHWSPVQTVAHVCLSIISMMSSCTKKELPPDNDLYVKNASASPKKTAWAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD48</accession>
    <name>A0A367KD48_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_014657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000079">
        <property type="protein sequence ID" value="RCI00126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD48"/>
    <dbReference type="STRING" id="86630.A0A367KD48"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_uL24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057264">
        <property type="entry name" value="Ribosomal_uL24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="193" mass="22078" checksum="302F88883E81FFBE" modified="2018-11-07" version="1">MQSFRHSALSSRVAPKLKSVHPKDKLKQWNIVTGDKVAIIAGKDKDTIGEVKSVDRKNNTLIIEGKKLAKKHVPQQPGFPDGIFRKEMPIHYSNVMLLHPDTQMPTRIDRRKVEKTLEDGRIVSKWTRFVKGTDIEIPKPERKYNDQGEEQFTTAPEDVLAVTYKPDPTQPPFPSEIVRELRNIYKKKPATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDG8</accession>
    <name>A0A367KDG8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RRM1_3</name>
        <name evidence="13" type="ORF">CU097_011633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 11"/>
    <dbReference type="EMBL" id="PJQL01000075">
        <property type="protein sequence ID" value="RCI00191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDG8"/>
    <dbReference type="STRING" id="86630.A0A367KDG8"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="803" mass="90929" checksum="8F1C57474B81494F" modified="2018-11-07" version="1">MFVIKRNGRKENVMFDKITSRISKLCYGLNEDFVVPAKIAQKVVSGVYQGITTVELDNLTAETAAYMTTNHPDFAILAARIAISNLQKETDDKFSSVIHKLYHHEHPKLKQPNPLVSKELYDVVMANADKIDAAIIHDRDFDFNFFGFKTLERSYLLKINNEIVERPQYMIMRVAIGIHGNDLESAFRTYDLMSSKYFTHATPTLFNAGTPKPQLSSCFLVQMKEDSIEGIYDTITTCARISKSAGGVGVAAQKIRGSGSYIAGTNGTSNGIIPMLRVFNDTARFVTQGGGKRNGNFAVYIEPWHVDVFEFLDLRKNNGAEEMRARDLFLGLWVPDLFMERVEKNEKWSLFCPDEAPGLWDNYGEKFDSLYIKYENEGKARKTVDAQKLWFAILEAQTETGMPYMLYKDSCNKKSNQKNLGTITSSNLCTEIIEYTSPDEVAVCNLASLALPKFVNRETKTFDFEKLHQVTKVVTRNLNKVIDVNYYPVEEARNSNMRHRPIGLGVQGLADAFILMRYPFDSPEAAQLNRDIFERIYFAALEASCELAKEQGPYETYEGSPVSQGILQHDLWNVKGSEHLDWNTLRANIKKYGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYTRRVQSGEFQIVNQHLLNDLIELDLWNDNIKNMMIAHGGSIQRIPGVPDDLKKLYKTVWEISQRTIIDMAADRGAFIDQSQSMNLFTAEPNFGKLTSMHFYAWKKGLKTGMYYLRSRPAVDAIKFTVDQLALKEMSLSETNGASNKIKSSKEAEEQQRLAQLQCSLDNRDACVMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDN5</accession>
    <name>A0A367KDN5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000071">
        <property type="protein sequence ID" value="RCI00251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDN5"/>
    <dbReference type="OrthoDB" id="10333169at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="152" mass="17005" checksum="660781C982C18857" modified="2018-11-07" version="1">MFLEPISFPSALEHPKLLASHAINAPEDVDCIFQHFLYTVVGEGVNHEAHLGNRYIERALNAASCDYNTNTELDILLLPNVGSTLTLSSIVSYPSPSFTVPDLPTEQYKEQNKILQKRKSTSSFTSLVAHKRVKLSRSLALSKKILQQLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDV8</accession>
    <name>A0A367KDV8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_015648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000069">
        <property type="protein sequence ID" value="RCI00290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDV8"/>
    <dbReference type="STRING" id="86630.A0A367KDV8"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="109"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="334"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="590" mass="66312" checksum="6A305D4F338F5D87" modified="2018-11-07" version="1">MVLSTIDNDRQKRISDLLAFVQERKKQNEEATRIETIEQAAIEKDPAEAPAVITKKVTTAPRPKAALADYKFEADKTGPILDMDLKPDIEIRPYQQEAVDAIIDRSSENKQDHVAHSGIIVLPCGAGKTLTSILVATAIKKPVLVVCSTIIAAEQFSKEFLRFTTLMASKTGMFAGAKKWPYNGPTGVLFTTYTMLVDSKNRTADSKRMSTFIDKTEWGLVILDEVHCVPANNYSKAISKIKTKVRLGLTATMLREDEKIGDLDTLVGPTLYHAKWKELADKGYIAKVICTQVESDMNPITQSAYDSVQMGNNLLGQAHHLKSLLAILNPKKMQICQRLIQYHEAKGDKVLVYCDHIDALKIYAEKIGRPLIYGGTPAEDARQLLARFQIEVPKTDEKLTWNQLAALRTLKAKQINTLFLSRIGDTSLDLPAATVLIQVSSHFGSRRQEAQRLGRVLRAKKRNEKGFYSRFYTLVTNNTHEVQFSEKRRQFLEEDCGYGYQIWKVGQEKDGGWEVEVYRDESSPNDDEVKSDPMTCTIHGAGERPYATDEEEKGLVSYLAGLKNFLVEEEEEEETTTPVNAGTKRKRDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE37</accession>
    <name>A0A367KE37_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ORC2</name>
        <name evidence="9" type="ORF">CU097_015750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000057">
        <property type="protein sequence ID" value="RCI00503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE37"/>
    <dbReference type="STRING" id="86630.A0A367KE37"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="255"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="481"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="550" mass="63144" checksum="0B65D7B7F94DEE73" modified="2018-11-07" version="1">MIIKVQVDSDIAEHIVNKVTPDALKQEEKLALKHKGYTRRSKSVRFIDAGLTVSKDQTDDPMDTDHGEDMSEGLSHHRIVHEEEDEEDKDVSGRSMFGFQSKRKRASSMMQKAAEVQNESQTPVEENKQETNSRKSGRRVKPTMKRKQLEEEYSASTQSDFSKKRRIQRQLELLKDDQKSSDEDQSSSDEEEEEEVVVKSRERDGDTTEGYERYFLDLHGKAQTSNNTLSKLQVLEPHEFHLILQKTQKKHRSEMHTLFEMQKQHFSQWYFELHSGFNLIFYGYGSKRNLLNEFAQTALTNGPLVVINGFFPSISIKDILLKITAGALGVQVPTGQIQDHVAYICNYFSREDREYDNLYIIIHNLDGPNLRNERTQTALSMLASANNIHLVVSVDHINAGLLWDNVKSSRFNWIWHDATTFDDYLVETSFENSLLIRSSELGGARGAKYVLDSLTTNARGVFKILAEHQLMEMEIANMDGKGNESVGLSYGQYYQKCREGFFVSSDLALRTELTEFRDHKLISSKKAMDGTELFFIPLDKSTLLHILEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE59</accession>
    <name>A0A367KE59_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plasma membrane ATPase proteolipid 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PMP1_2</name>
        <name evidence="7" type="ORF">CU097_015275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000057">
        <property type="protein sequence ID" value="RCI00496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE59"/>
    <dbReference type="STRING" id="86630.A0A367KE59"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8258" checksum="19490A854FD8CB4C" modified="2018-11-07" version="1">MLGTCCLIFIIILLPPLGVFFMRGCGADFWINLCLTILGYLPGHIHAFYVLVKDREERQAAANLGPPAYAPVPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEA0</accession>
    <name>A0A367KEA0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRPT1_2</name>
        <name evidence="7" type="ORF">CU097_014395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000053">
        <property type="protein sequence ID" value="RCI00563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEA0"/>
    <dbReference type="STRING" id="86630.A0A367KEA0"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23604" checksum="C99C8EE732D2EECB" modified="2018-11-07" version="1">MSSQPEEKVTSLSKKLSYVLRHGALKENLKIAPDGFVKLDDLLKLRRFKGVTYPDIQYVVDHNDKKRFELKEEDNVYYIRATQGHSIPVINTDELLEKLDKVTTPVIHGTTMKAWESIKNDGLSKMNRIHIHFAIGLPNDPNVKSGVRKSSEVYIFIDADKAMKDGIKFYKSRNDVILSDGIDGTIPPKYFKKAIDKHGDVLYEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEB4</accession>
    <name>A0A367KEB4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">URA7_2</name>
        <name evidence="12" type="ORF">CU097_008630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01000059">
        <property type="protein sequence ID" value="RCI00450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEB4"/>
    <dbReference type="STRING" id="86630.A0A367KEB4"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="318"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="570" mass="63838" checksum="94D9432B015A8FBA" modified="2018-11-07" version="1">MTKYVVVTGGVISGIGKGIIASSTGTLLKSLGLNVTAIKIDPYLNIDAGLMTPLDHGEVFVLNDGGEVDLDLGNYERFLDVELSRINNITTGKIYQEVIERERRGDYLGKTVQVVPHITDAIQNWIERVVELPIDKSGAKPDVCIIELGGTVGDIESAPFIEAMRQFQFRVGHDNFCLIHVSLVPVVGSVGEQKTKPTQMSVRDLRGAGLSPDLIACRSSKPLDDNVAAKISMFCHVAPEQVLAVHDVSSVYHVPLLLKKHGVIDFLRQRLKLDTVMVPDDRRLAGEQLWKDWAMLASSYVHLHETVTITIVGKYTNLHDSYISVYKALEHAALAHKRKIEIKWIEASDLEQETRQSNPIKYHESWQYVCSSDGIIVPGGFGSRGIEGMIMAAKWAREHNIPYLGICLGMQISVIEFARHVCGMADANSTEVDPDTKTPVIIYMPEISKTHLGGTMRLGLRTTLLEKGCKHSIVRRLYGNKSSINERHRHRYEVNPEYVNVLEKKGLKFVGKDESGQRMEIIELENHPFFVGCQYHPEYLTRPLKPAPLFNELILAVMRKLMHDNMSNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEI1</accession>
    <name>A0A367KEI1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000049">
        <property type="protein sequence ID" value="RCI00625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEI1"/>
    <dbReference type="STRING" id="86630.A0A367KEI1"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="362"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="476" mass="54600" checksum="353A2CFD0532E75D" modified="2018-11-07" version="1">MYSSNGKQHVVEAAITDTRVENIGSIDWTPIYRPTCFSISREFLQMTRASDVCIIINNLHPDIKQEDLWNYFDQSAVSPDVLKSKPLFVSSHQLNVDYQHLSSSKKNSLRSQKFSFTLTCLNKALKDVVIKRSNGSTTVIVAAKYPAYFWRLKNAQEEKNFFDFSCWERVTEIPLHAETQSNKDPIKAYTNSSTSIRLNSWSVYLIELTLDDDEHKKLSLRLEAATAQKMWHTAVAQVMKASKSKINYEEQYNIEEDFFETIENLEPHVACTIIHNTFKKNPYITNPPEVIPEDHAYLRKVIITPTSVYPLQPVLQKMKHLQYQFKQHANRFLLVKFADEELNSIVPSPYPLQNDLIYNHIFKNNVLKQLKDEYKLYITNGARAFAIMHETGSLEQSEVFFQTSTSTGINTVCEVIEGPCVIFRYSTLSPGNVVLATVVNKPKLKNYTNVLIYSANELTDLPGKCSNDDADEDNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KET5</accession>
    <name>A0A367KET5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_014096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000043">
        <property type="protein sequence ID" value="RCI00735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KET5"/>
    <dbReference type="STRING" id="86630.A0A367KET5"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="62"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="327"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="931"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115729" checksum="9A5BA4265AB979B8" modified="2018-11-07" version="1">MNRDYTYLSEQQQQQQQYHINRFTMTTTPTTTTATTTTATDMSGPPRPISTAPAFQSIGYDEREKRTYELVVCQQPLHARMCGFGEKDRRPIDPPPIVQLIVKQNDVPVDIQSLQIPFFVLHVTLWSDDRTEERNIISNPPKCTRVLMGSLVSSPSLLKNAKNEPGLYFAFPDLSIRTEGRYTLRFSLMKLANSDFQENAKSKIVAQVFSDPFTVYSAKKFPGMTESTELSKIFAKQGLKIPIRNDEPCFFKKKNYFVIHFCTRFYKEKMDENQPQTLESKENIINTSLLLARVERHKDRLKSDPRPIFQQADDHIIDLFQACVQEQGLTKERGKQWQSISHANVYQLYAIYDTLSSDSNSYQTVIEKDIQSVIQDDLHQVNQEALARVLKAYSVYDAQVGYRHGMAPLVVPLLSEMEEKEAFATFVRLMELYDLRRLFISGLSECLSTYQSLLATLCPDVKRHLDLLRIYPSMYAASWFPSLFTNSPLPITQMKRLYDLVFLEGAVETTLRFSLCLMQRNEKMILSMNQADQVLAFIQSSEFFACYPHDAALFYQDMMQLNSAVQHQITQTADLARTVAQLQKENTQLKMQGMEQEAAQLKLSKRNAVLEKRVKKYKVKLAHAAQTQLPPASVPVDLDDQEKKKKDNFNSFVESLRDTGDFGALIAGAIMTDTRLPSLLTVNNNNHSSSDEEDEDEHARKHQEQVDAALQNVTSELVAIKIDHFETTQRYEALYRHCEHLSRQLQHALEHQTTMMQKIIYLTSELEDTTSERDQLYQDQEQVLEMATVAKKTAAELQLEKMTLTKEVELLEQRVAELEKEKQQFFMPRDTFSEEVFAAHSILFGQQEQQKITQKEQRRHTMAIASLSQQENEYKTKYVESELRCRELEKYLAEAKVRLAELETSLLYPVRRASSVHLKRSSTASILARVTTPTTEPRASTESYASSTTSLTSMNSSQYNSKRSSMYSRIWNAFGNSPITPPPMTATTVPPTTTTVMKNSIICQEPQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFE8</accession>
    <name>A0A367KFE8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000034">
        <property type="protein sequence ID" value="RCI00908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFE8"/>
    <dbReference type="STRING" id="86630.A0A367KFE8"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="86" mass="9907" checksum="7F25485E93E06E61" modified="2018-11-07" version="1">MSAAANAAKKSFWSIWYKPEVAPIFVVVGGACSLAGWYLTRLARGPEVVWDRTRNPYPWQNIDQNTQVKLMTVNQKFDKVYSRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGN4</accession>
    <name>A0A367KGN4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL31_2</name>
        <name evidence="4" type="ORF">CU097_012501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGN4"/>
    <dbReference type="STRING" id="86630.A0A367KGN4"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="13896" checksum="E047B17F0AC9B103" modified="2018-11-07" version="1">MPKSTPQKRSTLADVVTREYTIHLHKHVFGRSLRKRTPAAVKAVKTFAQKAMGTKDVRLDPALNKALWSRGVKHINHRIRVRIARKRNDDENAKEKLYSYVTYVPVANFKGLETTVVDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGW1</accession>
    <name>A0A367KGW1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Golgi transport 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GOLT1B</name>
        <name evidence="14" type="ORF">CU097_015402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000009">
        <property type="protein sequence ID" value="RCI01456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KGW1"/>
    <dbReference type="OrthoDB" id="2250192at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="13">
        <location>
            <begin position="1936"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="790"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1860"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="961"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1283"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1441"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1896"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI01456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2141" mass="244701" checksum="137601542FBAA8EC" modified="2018-11-07" version="1">MWLSDSQKIGVGLTAFGVFFMMMGVILLFDAGLMAIGNVLFLSGITAIIGLKNTFTFFGRKEKLKGTICFLGGIFLVLSKYPFFGFIVEIFGFLNLFGDFFPVVFGFLKRLPIIGNILSHPMISRIVPRESRTRVQLEEFRRVQTLILFLQQLFQIPLKSDTIPDILKELKDELPIPMNTDITEDDLIRLLEYIQQQYQAYTIKKHLSNKELTFSEYTQSFTPQHVNDIKNVFLSWLNSVLSDYIQLIQLEWSSGFYLLCCIHYHHPSLVPNLHEYISLDDASLFNTATQLLYTTFNIPSIIIDHTSELNILSYYIELCLPVFTIPSHESIDQRHQDIERFKSILNQKKTTTTATYSYQQLRITKTTKYTSQHDDIIPSPELDTLDQHINSVTEKMNSLLHRLMLIIPTRSCHNYSNISNSITSESVEFFLTDDNTSTTRSTSSIIHSDNEIIRLLHPLQAAEEDYSAYDRNFKSLQAEFQTLSDGDYHLLQLAFDQLDPQWHTHPFVVQRKTQLHQHYTSLAQEFEKSDSTLAHFRRGFAFARMCNSIRQELDFVQNKMVKSITSFHDIHELELAMDKTTDMINTLKFNFSDLLNQQPPNPSCEESAGLVCTTLDRYDPAYLQKYQSVESKNQLVKSWVDEVRVWFTEAERIRQWIEIRVEQIKGTTLPDPLSAINISRDQVEALNASHSLLEKEIEAFDKEDMARLRSHVKSLTGTNKDLSPADTTTIEITLATLMSLDKLMHMLRRKSYDLQVLTQRVIWEEELEKATAWLQATEQELDDFLSNNARWAPSEEEEDEDRESTPARKREKLMAREKQKETVIQQLLTLERKVSEFDQGQFNKTVDSFQDLDNTSTTELPDHLESRQKACEQQFEDLMKRMAFARHVVEQRLNVMDFLYQAELVADDTAMLALDIKDAESKAHPGDNDREMTARVQSMHERTIQLVTATASRIPYPSHALDIDKESNAEANEKINQVINEKRNQLLLLSDELDQRLNAFRNILQLHRKAKEHLDDATRLCDWANERIQAVKKAKISIQQDLVTIDDLQRLERDCQAMISKLKNGKENEVVDLLTRIPSLLETSQKLNITSIDSDSLNEVSQQLEETFDRLQQVLDEHVLELEALRKKLEEGNTYFETARSLKTFVSETRLSLPALKQTCGFMTGQSEEQDRQRLNMLQHTLATIEHDYNSRQTQFDQLCSHFKHMKPSKQEDAEETRKIQDSVEQEWDALGKDIQDLKQFTETVGQWYERQRRLSIVNDTFLDILHDEIGRLTQSDKNSAELDAVQQRIDQATEMLNEIGKSIDEAQDSEKQDPLQIANYSCAKDRYNLLVSKLQTAKANMAALRSNAHTSLAFQSFLRDANKLMDTIQLQKEQVNRRMTVVGQARFRESAESVGGLESLVNNILQSVRTAESDYAGPLQAQVKSLLEKVKQFEPNSAERQTAQETLRSIHENMNQLKDVIASERKQAIFIQKVQTHAKGARDLQVWIDQCSSAIAQLPTDVCIVDEQDLLFDLEHYQQKIIQFEPTIQAFQAMPSKIWKHVNGDPVDLCAISLDRDQVKDVIDQREAKILKAWQDLKDQHAKARSSVDFSKRGVEAARKVKAVLMQIGDLKERVSAVRICKPKENEQDSDDLQNVLQCSLTDIPTEHRLASAKAELGILDRDIEAQLLPAIKQLDLMLNATFNNSQDDMFSDQRQEISSAVRGLLDLVKCKRRAINEAERMQEFLTVMEEVEVLLLALAEVVARASPDNARMNEDGTYLRTDLQALLIDLDTRYGYYEPKIIELMDELRDVSEHLLGDRRVVSCIKQFTNKWAQLQSEAAARKQELTSLIGPLIDTNFDFIKATEGMLLARGRRAAATSGTLSKRSSAPVLAPQPKPTQTMPRYMTGLNRKPTRASNNDGSVSPTARRVAARQTAAQQQRVRATNKTPEAYVADPKNDLDVAVGNIVNDSPYKIKIKMVPGEVGKYWFGEVNPKLAYCRILRSRMVMVRVGGGWVELSQFLRDHALLESGTFVTPDKTTYRASLPPPASPREGVQEGFLNTVVGRNTPVANNRRSLHGGVGVHNNIIALRGQAGGPPQLKESRSTPYYRGMSPIPTTYGIKSGNKFVVTVDDKGNQVEVKMTKAKNHDAKFITPRRINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IME0</accession>
    <name>A0A367IME0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004879">
        <property type="protein sequence ID" value="RCH78844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IME0"/>
    <dbReference type="STRING" id="86630.A0A367IME0"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH78844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="77" mass="8403" checksum="0F4105F3BBF8B55D" modified="2018-11-07" version="1" fragment="single">MSNQPIVLITGCSSGGIGYSLAKVFAKEGNKVIATARRVEAMEGLEEFGCDKERLDIMSQESIERVIENVIAKYGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP07</accession>
    <name>A0A367IP07_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004539">
        <property type="protein sequence ID" value="RCH79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP07"/>
    <dbReference type="STRING" id="86630.A0A367IP07"/>
    <dbReference type="OrthoDB" id="3264576at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="2">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="296" mass="35000" checksum="61A702F9B1F28ACE" modified="2018-11-07" version="1" fragment="single">VLAEEKKRRVSKRAQKLEEKLKNRSVTSLFDTDGDLSKHNIIEGSRQTRKRTASTEEMPNKRKRPDSRVLIKNARDKLMPKPTTELDKTRNEAILQRQHELEKILDQHESKVKELYHLEMYQNMLDFDPKKNLVNDLIYQKFIQDFNLWDIAYNTSQHKNTVQLLESTIRSGTGTRRLIKQYKKLNDYLSTFVTATDDEEMTPEAREALIEKERGIRQRLDQLYQAGGFTTQLQAIAHRRPHQPPRQHDLFHDTLLAHVQSSAKLFAANSKYRRNMARKCARAVERYWENIWAQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP68</accession>
    <name>A0A367IP68_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004504">
        <property type="protein sequence ID" value="RCH79436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP68"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="24956" checksum="CB470905BE2E7DA2" modified="2018-11-07" version="1" fragment="single">PGTARGNPDYVNVLKTLGLTVLAPLVVGQFIRFLFPKQIKYIAAKCRFPIINSLALLCLVWSVFCDGVASDAFHRTNGVDIVAIIFVDIFMYLFGCATCIYIARLPWPTKNEPKWVSKWRFSRKDTVAIMYCGATKTVSMGIPLINVLYANTSYGIVGLLSLPLLMYHICQLFLGNFQVALLKKWVEKDERDDMSHPDDTNEQVLPSTDTSAMSTLRKRNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP74</accession>
    <name>A0A367IP74_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homing endonuclease LAGLIDADG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004484">
        <property type="protein sequence ID" value="RCH79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP74"/>
    <dbReference type="STRING" id="86630.A0A367IP74"/>
    <dbReference type="OrthoDB" id="2222997at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37520">
        <property type="entry name" value="INTRON-ENCODED DNA ENDONUCLEASE AI2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37520:SF1">
        <property type="entry name" value="INTRON-ENCODED DNA ENDONUCLEASE AI2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="1">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="1">
        <location>
            <begin position="126"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="25764" checksum="3F68F3608FC632E3" modified="2018-11-07" version="1" fragment="single">LLVEYSMLVGSSETVRMFSTIMTSHEKSDLKIRQWIAGIIDGDGSFSISKLGYVSLEVVIELRDEACLYKLKHRYGGSVKATSHAKALRFRLHHKTGIQAVINDLNGLLYNPVRIQQFQKYISAYMSGLFDSDGSINLNITSQQVFITITQKSPELLYIIASVYGGKVYSCNTTYKWTVSRKSEVLSLINDYFHWNGCVSAKNKRFGIVKEFYRLSSEGATKATIDSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQC3</accession>
    <name>A0A367IQC3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UBC13_1</name>
        <name evidence="6" type="ORF">CU097_001651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004347">
        <property type="protein sequence ID" value="RCH79691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQC3"/>
    <dbReference type="STRING" id="86630.A0A367IQC3"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH79691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="105" mass="11898" checksum="2D50C19B1953B527" modified="2018-11-07" version="1" fragment="single">MSSAASILRRQFKELTRNPVPGFVVDLKDDNIFIWDVALIGTPKTIYEGGYFKATMTFPEDYPFNPPTFRFNNEFYHPNVYPDGRLCISILHPAGNDPISGEAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQE3</accession>
    <name>A0A367IQE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004211">
        <property type="protein sequence ID" value="RCH79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQE3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="77" mass="8630" checksum="4B2CDB0AC6E248C6" modified="2018-11-07" version="1" fragment="single">KTVRTYISEDDMRNTLVEDEASSDGAVQDSKLNIAGGKEDLKSPECFQVRLKIETMSSGFGGRLTQNKSFVDFDERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQH3</accession>
    <name>A0A367IQH3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004212">
        <property type="protein sequence ID" value="RCH79912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQH3"/>
    <dbReference type="STRING" id="86630.A0A367IQH3"/>
    <dbReference type="OrthoDB" id="2406983at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="33999" checksum="4300F9BB030A4160" modified="2018-11-07" version="1" fragment="single">MNALVSSQQQQQQQQQQLLQKQKELQQQQQRQQQLQQSPPPPPQQSQSPQKQQEEEERNLTKEESKEAPLAHNQQLHQQSLHHHHQQQQQPQETQLNPSLMPQGTTQNWSANTNTQYAAPTFSHQSHVNTTTTTTHDAKAQNTSVPPMAQALPTAGVIVEVSHITYSRTYYFQLSPEATIEPLIAWLRLTFQDPTISGMVLQYKGFDGLWKCLLNRDDSLKRVLKQNLKNNTILQMRVPCEQDLLSSGYTDKRLLALTTKPIAPSIEQANATGQMMEDNNTNNNSHNSNSDNNNNNDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS43</accession>
    <name>A0A367IS43_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fumarase C C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003879">
        <property type="protein sequence ID" value="RCH80505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS43"/>
    <dbReference type="STRING" id="86630.A0A367IS43"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarase C C-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="8036" checksum="53F3BB9217193475" modified="2018-11-07" version="1" fragment="single">ANEKRIESIMNESLMLVTALNPHIGYDKAAQCAKKAHKEGTTLKEAALSLGYLTSEQFDQWVRPENMISAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS51</accession>
    <name>A0A367IS51_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003898">
        <property type="protein sequence ID" value="RCH80482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS51"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9110" checksum="4A2D643567417C38" modified="2018-11-07" version="1" fragment="single">PLFGVLTDVPGLGISAYRNHSADPSPSTTNSDITEDANTIPHVSIEPGTSYTLTIKHYEDTIPYLLKKLFILPSDKRAVRQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS90</accession>
    <name>A0A367IS90_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003869">
        <property type="protein sequence ID" value="RCH80522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS90"/>
    <dbReference type="OrthoDB" id="2257766at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9861" checksum="1CEC917BCE9D3076" modified="2018-11-07" version="1" fragment="single">RREEPKIFFTIGYGQLVKEAIALAGIDTTQFKAHSTRPATSIKTYMTGIGVQKLKQHDNRSLRTDKSERYYLRPPQQHQEGKAVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISY0</accession>
    <name>A0A367ISY0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANKRD52</name>
        <name evidence="5" type="ORF">CU097_001353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003837">
        <property type="protein sequence ID" value="RCH80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISY0"/>
    <dbReference type="STRING" id="86630.A0A367ISY0"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH80581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="42166" checksum="65D9E6FAA1A8D6DF" modified="2018-11-07" version="1">MHSITITTNNDNNNDNNTEKIILPSPPSSPVDQTNTNSRKRALSISFLQNPIPEPTKKCKFNYLEPLLKDTSSPNQCDPQYHRSLLSWACIAQSLEKLKELVRNVHLDINQTSGPNKTTALHEASFIGFDKGIPLLLQHSEININATDHQGQTAVHYAVQRNQVECLKILLSSGARIDIKCQKHNRLPIHTAAKYGFKNCLRLLLSYSTCHANNPTETDMVWSSDSSQAVVEYAVISGNVHQLTLLLDYDANQQYRQSNELVSLAVHWNRLECLRLLLQRECPVDSKCLMMAVQERKIDMVRLLAPLTTTCQLDGENPAFLYAASHGFLDMIPDLFTLSTSKECIQQALFLASSIGLHEKLGFIISSTIKSLLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU58</accession>
    <name>A0A367IU58_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003522">
        <property type="protein sequence ID" value="RCH81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU58"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="64" mass="6946" checksum="A18A86B3F8EE7AFE" modified="2018-11-07" version="1" fragment="single">TNTNPAENGKTGPDAVIIERLQMAFGKSIEYGKAKIHQCNGSKDFGRPAVVRFFGEVQEAARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUH4</accession>
    <name>A0A367IUH4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003473">
        <property type="protein sequence ID" value="RCH81355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUH4"/>
    <dbReference type="OrthoDB" id="2243436at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="372" mass="42446" checksum="FFBEEA15CB529B34" modified="2018-11-07" version="1">MKPFITKGQASCMVLGEAVTESNRLKCKAIIEETPFQVVYTITEGKMRPVAVGKQVVERDPFTYQKYPETPPSSPTLSYIDIDEAELTETSDSDNSIDSSIKLTKDSVLDFFACIASKTKPVANEEQFIYRHWPMEELVDLLNGYLTNVESNNLKTKVADWLAKDGRFGRSKMCRVGAATVRIRSLWVLKEEHRRDALNKVFNTLSYRKKVRETSGNWLTVGYCRKSRCNVSQEQRAKLIQRMVEILKVKCLCEKVYVSPICSASSLLLERDFSNNTATVMDKIKYKDGHFQDFVMLAKSSSANIRLVILDYAGLTTNPEDLLKLIRKLKSVKEIVIYKGYKFEILSRQQLLQGEVAKKFDCRTPPVKRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV23</accession>
    <name>A0A367IV23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003420">
        <property type="protein sequence ID" value="RCH81469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV23"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="68" mass="7745" checksum="3201D22A7CFE80A2" modified="2018-11-07" version="1">MSEQIAPHTISDNDATVPISSMLSVLRLPFPQTEPEEERYWEALARMATIHARQQRENAVKDLEIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVE4</accession>
    <name>A0A367IVE4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003345">
        <property type="protein sequence ID" value="RCH81647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVE4"/>
    <dbReference type="STRING" id="86630.A0A367IVE4"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="109"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="358" mass="40892" checksum="B99D150777305A5E" modified="2018-11-07" version="1">MITSFFDTDWRIFGQEATPYSQCGWEDIEPGRHEYPFALKFPNVNYPPSIDEPAGFSVRYVWSAQADGPALQSGLKSKEYITPYRPIIVSIPDKEWVYKTTVLKEKKALIEVQAKLDKQAYCPDEAFQMQLNMTMLQSDSRISGLTYKFRKHHEGKMLVQQGTAFREQIRIVLTDQIQIQPNKAISLPIQFDIPTRLVSPSFISRHTRVHYDLLITVAVEQQGHLFKSNYLTEFSIPIAIANLPNDQLLRIPQLTAIKDYRQSKECPLFFDPQLEEPPLPQGVPSELIGPLTAALLNNTNGEDQPPSYFSLPELPPQFEIRKERHEKTVFLTRQARGAPGSGELIEATVIPGLFDEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXD5</accession>
    <name>A0A367IXD5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003040">
        <property type="protein sequence ID" value="RCH82363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXD5"/>
    <dbReference type="OrthoDB" id="5559822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="19450" checksum="AF9851EF38946D57" modified="2018-11-07" version="1">MGVNLSKVNDANILKRYKAVQQYPKRIDISMIGYPTNFRHTYHVGTNCPIAEQTTISLSDEKKPIPMPDVIEHAHESITSLQETEKRESCCMMTVGQNEQITSSLLSFSGLPNTDITSHDPDAVSLVDLYSESDFKAKIDAQIKEILEKRPRPTRKRYINENLSLNKPGLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY12</accession>
    <name>A0A367IY12_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002996">
        <property type="protein sequence ID" value="RCH82489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY12"/>
    <dbReference type="OrthoDB" id="2286551at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="68" mass="8085" checksum="50C22F589C908D5F" modified="2018-11-07" version="1">MEELHKNMLNNYISDVKVERHIFNDITELFGSFNVEKDERDSIKLALFDIYKKASKQDRKLVDVLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY40</accession>
    <name>A0A367IY40_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epsin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ENT3_1</name>
        <name evidence="3" type="ORF">CU097_004604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002961">
        <property type="protein sequence ID" value="RCH82598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY40"/>
    <dbReference type="STRING" id="86630.A0A367IY40"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="477" mass="52087" checksum="57B49305C973AD7B" modified="2018-11-07" version="1">MNSFSNLNLSIPDLWEVRVCISLCKNVVLNYTEMEAKVHEATNNEAWGASSTLMQEIAQGTYNYQYFNEIMPTIYKRFTEKEARYWRQIYKSLVLLEYLVKNGSERVVDDARSHISMIKMMKNFHYVDEKGKDQGINVRNRAKELVELLNNTDAIKEERKKAKKNRSKYTGVGSDGGMMFASSGGYSGGSYSSNPRFEGFGSDSAQNDFYDSDITKKYDEPSSPPPTRATTATTPSSASSSRAEASQSKAKVTANDLFDFDEPAMAHKQATNDDDWGDFAAGNGADDDFDDFQSAPAPPSTTATAQGHASTATAITTNTTAASKKTNDIFDLLGDDSFTAPPAPQQQGSGLMLSQAMSYDTLAANRTIPSNTSSPIQQATQIKNTGKVSETESNTSIGGIWSQASSFVSLDSLGKKSEPAKPSTGPSMNALRNSSSSANWGNWGAANSSNVQQQQQPQQRQQQQQTKQSSAFDDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYE5</accession>
    <name>A0A367IYE5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="17">COPII subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SEC24_2</name>
        <name evidence="17" type="ORF">CU097_004198</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002932">
        <property type="protein sequence ID" value="RCH82676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYE5"/>
    <dbReference type="STRING" id="86630.A0A367IYE5"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="13">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="14">
        <location>
            <begin position="170"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="16">
        <location>
            <begin position="414"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="15">
        <location>
            <begin position="508"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="12">
        <location>
            <begin position="639"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH82676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="771" mass="85135" checksum="ACE8A2886AC27C5D" modified="2018-11-07" version="1" fragment="single">MGPAAVVPAVPLLGARPHIADIDNTGPQVRLPPNISVTDSPFVNADPSYQCSTLNAIPATESLLKKSRLPLALVLTPYRSLKEGDDSVPVVRDSVIARCRRCRTYINPFATFVEGGQRWKCNMCFLLNDVPAAFDYDSITQQPADRWKRPELNYGCVEFVAPTEYMVRPPQAPAYVFVIDVSYSAIQSGMVATAARTILDSLERLPNDENRTKVAIITVDSSLHFYNLNPSLNEPQMLVVSDLDDVYLPSPSDLLVNLTESIHILKALLEKLPELFKDSMNVNNALGTGLQAAFKMLSPIGGKIICLQSTLPNTGAGALKPREDVKLLGTSKESSLLNAASPFYKSFAVDCSRSQVACDMVIFGGQYSDVATLSCVPHYTGGQTYYYPGFNASRTEDAIKFAHEFSELLAEQIGLEAVIRIRASRGLRMSAFHGNFFIRSSDLLALPNVPRDQKYVVEVTMEDDLKTPTVCFQTALLHTACNGERRIRVVTTCLPVSSSMSELYASANQQAITAYLGVKAVERGLTSKLDDARDAIVNKLVDIFGVYKTHVLGSGQGSTPQLTAPDNLKLLPLLALGLLKHDGLRQSSQIPSDMRSNAMNLLTTMPIQLLIPYLYANLYSLHNMPPEAGEFSEKGVIFPPALNLTAENLEPHGCYLLENGQNMYIWVGRNVVPQLCVDLFDVKSYEGLKGGKITLPVLNTPLNKKVNTIIGKVREMRRGNYHPTLYLVKEDGDPYLRLWFLAHLIEDRTDNIMSYQQFLQHIKDRVSSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ33</accession>
    <name>A0A367IZ33_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed RNA polymerase III subunit RPC5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">POLR3E_2</name>
        <name evidence="1" type="ORF">CU097_005728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002834">
        <property type="protein sequence ID" value="RCH82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ33"/>
    <dbReference type="STRING" id="86630.A0A367IZ33"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="32547" checksum="8265B568EA9FBE53" modified="2018-11-07" version="1">MPITDDRMSIGEEEDEVLAEYPIYLTNELSKYLYLFQYPMRSTPFNARTGPTAARLKPNAKMVELDLPLDTRSAFYSTERGEDFAMGLNDKTIKTAYDRRMEEHEEELNGYYSKGSKKKEEELLDKMTLTSTQIPTQTKYAIGVIRDQELHLTPIRTTIQLRPGFKYIDKIDEKWKAANKRIQDVEKQEEKKKTTEPGQAQTVQVSVKNAEREGSIRKNIYSLSVKNAEEEEWQPVVYYDQLSLQAEKVSEKLYAGNKEELICTTSNDEYLTQLSYGAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1J7</accession>
    <name>A0A367J1J7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002548">
        <property type="protein sequence ID" value="RCH83813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1J7"/>
    <dbReference type="STRING" id="86630.A0A367J1J7"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="238" mass="27657" checksum="E53EAB671902AC21" modified="2018-11-07" version="1">MSLKQILQPSQHYLEIAKQASITLKEPRKQLLILDLNGTLVSRVKGGGSMFVRPFSDQFFDYIFDHFTVMVWSSAQPHSVNFMCRMFGSHQSKLALIWDRTSFGLSIEEYSRKTATIKDLSKVWQRLEEFDATNTILLDDSRSKTVLQPFNVIHPTEFIHGSSSFRSSGECELVQIIDYLKVLRYQSNVANYIMNHPFKSIFNHQLNSFKVLHFIKSEKDGHEVDFNYVKPANQHVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J200</accession>
    <name>A0A367J200_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002535">
        <property type="protein sequence ID" value="RCH83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J200"/>
    <dbReference type="STRING" id="86630.A0A367J200"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="6731" checksum="1CF80BFE2803FC5F" modified="2018-11-07" version="1" fragment="single">MSGFNIATPSMATPAMQTPSIQTPSIPTPLHNSTPFALPSTPAPNDAPTPSRDANPYAVAGITPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J292</accession>
    <name>A0A367J292_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SHE9_1</name>
        <name evidence="13" type="ORF">CU097_002623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002480">
        <property type="protein sequence ID" value="RCH84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J292"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="42906" checksum="66AE23E37804618D" modified="2018-11-07" version="1">MSFRAIASKRILVTQRCLCRQSSSFTGSKNSLEKIQTDLKSQLDQYINKLHKASDKFKQLTSEVNNSKEALQKASRVLNELTGYNHIETVKEKVTRQAALFESTRDEVQVAKREYEQAIETRSSTQRSINELLQRKHLWTADDVTKFTELYRLEHAHTQAEMTAKERYQTCEKQMDREYMELARSIMERYHEEQLWSDKIRSASTYGTWALMGVNLLLFVAVQTVFEPRKRKRLTDRFEELLVAKVNEEEEKFKHVFESLDEKDRLLVQQQIALMEAVNTLTEHPLFDQATLDALKQTNNTTDNPIESSETNKATPHQTPLLDDDNLIKAILLPIENQVEDKDHSYLWQSVQSAIAGGLVTAIAIYFLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2U2</accession>
    <name>A0A367J2U2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002445">
        <property type="protein sequence ID" value="RCH84159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2U2"/>
    <dbReference type="STRING" id="86630.A0A367J2U2"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF6">
        <property type="entry name" value="LETM1 RBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="8">
        <location>
            <begin position="135"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="337" mass="39187" checksum="C9408BA582C96D2E" modified="2018-11-07" version="1">MSFNIVRRSFPVKRLLTAGYSFPSSRAAVIIKPLPRYQPVRHFSYGYVRYNQLQTENKPILNETNEAVANQPTSRIGKLIQQSKELVKFYKDGIKLLWSNHKEAKVLQLKVQNEGYELSRSEFQLIHRAQKDIIKLIPFGIIFCILPESIPLLVIYVPAMIPSTCLKDSQVQKQREKLDKVRQKMTMNVLKSAEQVQGITPEDFLSLPKFQRIAKHYAYDFDLSRIDRRHLSAYCRFMGLNDYGTQGILKKRLAKYMDYIEKDDKLLAKEGIDNLDIKELSTAVEERGMRSLNESEEQMRRALKYWLAVTQNQQSGQITIPPGLLVFSRMFLLNAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3R7</accession>
    <name>A0A367J3R7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UFD1_2</name>
        <name evidence="7" type="ORF">CU097_006755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002351">
        <property type="protein sequence ID" value="RCH84489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3R7"/>
    <dbReference type="STRING" id="86630.A0A367J3R7"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="313" mass="34733" checksum="E9797F629E3F7FE8" modified="2018-11-07" version="1">MFNDEDSFSNSFFGGFRPSFGGFMNPNRGFSENYRCFPIAMMQHGHDRENVNYGGKIILPQSALEKLSQLNISYPMLFRLFNGAERTHTHAGVLEFIAEEGRVYLPQWMMETLGTEPGSIIEVKNVTLPLGSFVKIQPQSADFLDITDHRAVLEKALRNFSTLTVDDVIQINYNNKVYEIKVLEVKPSNEEHLGISIVETDLEVDFAPPVGYVEPSQPVQTVKSQMVIDLPKPVKTGFTAFQGGGQSLRGKSKPSTTDEGDAENGQDDGPLNLPFGTLYFGFPIIPPPSSNDNDQSEKPAFTGTGQTLRSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4G1</accession>
    <name>A0A367J4G1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002249">
        <property type="protein sequence ID" value="RCH84854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4G1"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017025063" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="22954" checksum="690E113260505D81" modified="2018-11-07" version="1">MRFTTFKIFLALFTAVVSAQSSPFYITNPIQGSSFKAGSIATITWLNGTPGNATVYVLTGNNPAAMTITGIKFTINGQDGKYNWKVPTDLLQNTTYSLMISYSTENGNTATAYSSSFTVIGSAGSAASQLPVSSAVSNASSVIVSSTAISSSAPSTTIVLTTSSSSSIPNTSASTIGASSTAAITQPATTTPRPSSDTISRHKASFTIINCMIALIAYVLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4G6</accession>
    <name>A0A367J4G6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002261">
        <property type="protein sequence ID" value="RCH84813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4G6"/>
    <dbReference type="STRING" id="86630.A0A367J4G6"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="426" mass="46098" checksum="BB3050D7E7F47D43" modified="2018-11-07" version="1">MDNSSTLIDENTPLVQNKQERQESFRDLKGHVKALLAAFYMAMIAGLNDGTLGSIIPRVKQYYDITNETISLLFLCSATGFFISAGFNGFIVHHIGQLKAIYLGGTVQLAAYFVLMMGLPFPIMASAMVCSGMGMALMDAAMNVFTANLPLATLMLNILHALYGVGAMISPLVATYLLEHDISWKGMYIFLAVCSIINLITITVGFMGVKLDEEHDEDNIDNQQSRKALTKAAILHPMTIIGALYILIYVGDEVVVGGWGYTYLTEGRHGDPIAMGRVISAYWAGLASGRILLGYLAGKFGEKLMITVFTMMIIGCLTVMCISADVVLNSSVIISIGLLLGPMFPTTISLASKVLPRSYHTTAIGFISALGAGGAALFPFITGMISGRFGILSMPYACIIMTLGMLVLWAMIPSDKPFFGYFQKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4T3</accession>
    <name>A0A367J4T3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002285">
        <property type="protein sequence ID" value="RCH84721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4T3"/>
    <dbReference type="STRING" id="86630.A0A367J4T3"/>
    <dbReference type="OrthoDB" id="2283214at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="377" mass="42276" checksum="895BB2BA15563B53" modified="2018-11-07" version="1" fragment="single">LRRKSGHHWVTAKMNSADVSFDMYDEAKNAVFSYGPVHEVMSIIKTGRVTLLDCSIRLKKSYSPSEKKPSHFEVSILISSIQVYGISNFALPPIISNASVNIIALRLKETDNSVSEIESSQLTKSESSQLVKVPLNTSIADVLAATCLNSVRRNYSQAIVYACQLMNADKDEIDKNEWIIEKMKLEPFSLFPLGPDEQPMADEQPVKLHGLAHRNNISELADKTFVCEPILSVKRKRDVDASIDNVCPDLASLIYRSPYRNILLNQHYFDLYESTTRWLNTDWTTEPQMKYVCAGAVLLNTNNGEAIIINTIEIYGDTKSVDTHRALSSPSDDLYAIPSTMYSDVWPSVHNTRDGRKLTINSHSCLGLATSNLRLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4W4</accession>
    <name>A0A367J4W4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002225">
        <property type="protein sequence ID" value="RCH84945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4W4"/>
    <dbReference type="STRING" id="86630.A0A367J4W4"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="39224" checksum="A8A61117C441822A" modified="2018-11-07" version="1">MNQASRGSRVVFVGNIPFELSEEQLIEVFKEVGPVASFRLLFDRETGRPKGYGFCEFYDAETAASAVRNLNDYEIGGRQLRVDYAAMDDNHQRSGHQGRHHHPPVQQAPPPSMPPPQPMSMQPPMQSMPMQQPMQPPMQPPMQPPMQSSMQPPMQAPMQPPMQTPMQPPMQPPVNKSLVGNASVDEISKVLASMNAQDLFTLMSQMKQMSFERPEFTREFLAANPQVAYALFQAMLMMNIVDPNIITRIMTANPAAAPVASPVQPIIQQPQPVQPTRPAVINSPVQPVSAAIRAPPPPPVVAQPEVPQDETEQQKALLMKVLQLTDEQINELPPQTRDQIRQLKAQLTMQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5E2</accession>
    <name>A0A367J5E2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002170">
        <property type="protein sequence ID" value="RCH85153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5E2"/>
    <dbReference type="OrthoDB" id="2282747at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9969" checksum="ED45EDBA168A6D41" modified="2018-11-07" version="1">MGEQQMTPSEQFLAKRWFIIGAYQAGATDKVISNMVGLSSASVHNVITQFKRTGSPVRKRLHLNEKATGYDDLGRIIDSDDELGVKISIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J684</accession>
    <name>A0A367J684_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002103">
        <property type="protein sequence ID" value="RCH85420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J684"/>
    <dbReference type="STRING" id="86630.A0A367J684"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="63" mass="7522" checksum="7D36C165BD7E7BEE" modified="2018-11-07" version="1" fragment="single">MTQYLIAVWDYTAEGEFELSFKQGDRIKLLEKHNDDWWEGELNDQIGFFPANRIRLETTEVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6K4</accession>
    <name>A0A367J6K4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_004731</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01002062">
        <property type="protein sequence ID" value="RCH85584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6K4"/>
    <dbReference type="STRING" id="86630.A0A367J6K4"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="205"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH85584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1131" mass="130566" checksum="0558D76A0A8BB3A5" modified="2018-11-07" version="1">MVVNATNDKIVISTKENELTAEKKPSVLDEETMLKTLLPKNNDLETEETGVFHWHIKDWKGLEDKCHGPVFHVKGFPWRILLFPRGNNQKKSFSFYLEVADPKDGTLPEGWHVCAQFALAVSNPTDPTLYYSSHANHRFSADEIDWGFTRFYEIEDLDKMTSKAGPFLVDNEIVLSVFIRVVKDETGVLWHNFVNYDSRKETGFVGIKNQGATCYMNSLLQSLYCTNKFRKAVYDIPTDNDEPTKSVALALQRCFYNLQYSSAPVGTTELTKSFGWDTLDAFMQHDVQEFNRVLQDNLEEKMKGTPADGAISKLFQGKTKSYIKCINVDFESSRVEDYYDIQLNVKGCKDLQDSFDDYVAEEILEGDNKYMAEEHGLQDAKKGVIFEDFPPVLHLQLKRFEYDFMRDTMVKINDRHEFPPEINLDKYCSNSDKDGPYDYQLHGVLVHSGDVSGGHYFALIRPSKEDKWFRFDDDRVTPASKKEVFEENYGDEPLRDSKDLLSPTFNSRINSARMMKKFTNAYMLVYIRKSKLDDILDPVLESDIPVHLKRRLDDEKAMIEKRKKERQDMQHNVKVAVITDDSLKDYQGFNLAVFDDRYLEVSPHVEVFKAPKIEKVSEFKKQLMDHYKLEANQLRLWYIQTRQNKTNRVTQCLTSAEDKLPLEKLKELTCGSAFNNGLTKLYLEKSEKDKPLPSLRNDQVLLFVKYFDVKEQKLRGLGHMFVSLNDKIASILSNLNERAGLKKSTSIQLFEEVKPLSIEPIKTDQTFRKIDIQHGDIICFQISLSQREMDDLSKKGYITTAPDYYASLYNRSFVLFKPLPSTQHKQEAKLVLNRHSSYTAVAQELAKEIGANPNRIRFTSSHPITHQPREVIAYKPTTKLEEMIPNLPKPADYQQFVSFEKMNTPILFYETLEVDLADLESKRSIEVSVLGPTLRRETKVTALVSRAGTVRQLLDQVIAKSKMEVKDPAKIRLYEAVDSKLTKEFSLEQPVDNVATEKNAIVYAEPIPKDELEMNLDTDRLVQVVHYHNKPTELHSAPFRFVAIKGETFEETKKRLQKRTGLGDMDWKKVKFTVIRNIYSPEPQVEPIDANDFELRKARLQEEDALGLDHVDKSSKSRFTHVFDKGIFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7J6</accession>
    <name>A0A367J7J6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001993">
        <property type="protein sequence ID" value="RCH85880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7J6"/>
    <dbReference type="STRING" id="86630.A0A367J7J6"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="238"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="392" mass="44570" checksum="59559BFDA2BEDC31" modified="2018-11-07" version="1">MFKRSSSNVLNLSKSKSKSTNDQLFQDRTQQQSNPFAGRRQSGPNAVSQYKRKAPMPFTVNSNDDDWGDFQASKFQKPKEKQEKPAFIKPVKKRRLFEPSGHDTNARAELLIDTVFRSTDEANDDIGKETCPYCGDILEPMTNSLRKYLEQKETKDRAHEQEQLARLKRENAQSSFGTADWVVEQRRVSTTDKHEFCKLHHIELVVKKQGNERGYPESIDFKGIEKRILGFKSQLDDVIDGKVKSKFKDIALDAYSEYGQSKARSAVNVLVRLENCVPGYYGPRGSAVITEVLSKLYLQSGILTKELTQPQLPIEYIQQVLMPEAGLRLIRQDLLNKSRRGYTSIFHAPPIPPNLTETAEKVMTESREYGAAMFPEAEDESITIESDDSDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7K8</accession>
    <name>A0A367J7K8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001992">
        <property type="protein sequence ID" value="RCH85885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7K8"/>
    <dbReference type="STRING" id="86630.A0A367J7K8"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="7">
        <location>
            <begin position="886"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="853"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="936" mass="107811" checksum="D31A40BD7CC5EC10" modified="2018-11-07" version="1">MAKSIEEDKPTDRNVVKGLVKKIKALEKERDGLLQQDTVSQKSIATLKNQVEELLLEKEETKKSLIQLVNSADEAKQKLQEELEGSSRERAEHEKIKESLEKQLEEARLERNELEERIKVLEQANQDGADHEQLEKENARLQNELNKQDNELKEAVSRLQQDLDSLSKEKAALEEKLSVETEQNKTLEKRIQEQAKGVAESRSTETKLKQEKAALESKIKELEKKQQETPKQKSKNAANRAKNEMEAKLKVALKEKEELEKEKKKLAEEKLALEAQLSELPQDQGNDEKLSLIQKELQEARSSEQKTQEAMTELKKSNDKDKQELSDKLKEKSDTLERIQQEKKDLKEKYDTIQQENMELKSKIAESKEEVDRLTKEMDQIKQSAKDVEGLKTSLDEAQRKLQEKIKELDAQKTEKDDVIRQLSEKQQELQEKLVTTQSSVQTMAVARDALQKEKDDLSRQLSEAEANLEDAFSKLKELEQVSGKLAASEAQVKTLNNKLRDANEALKVAKDLLNERDQDLATARKSAESLQEEQEKSRKISDLLNKTKKQVSILEKEKSDLSAEVENNKEQLNRIKQECESYKSQLQQIRQEHDAISKTKADLKAEVGRLNAKIQSNASEISILQKERKEAVEAKDKIMDELQIKQAEFESSQSMSENLQHHLKESERIIEELNEKIAALEESRLIAEESKQEMDKRQKHWNMEQKRLEKELSNKEQENSKLQAANEQNKESISSLTDKVKSLEEKIEQLQTESKQKQASIEALETDKQQLLNKLKKMEDDLKTSTEETKEKEELNLQINQLKQEIETIKSTQNKEIEDLKTRESYLKTLNKTLKDEIRKLSKAQQPVTFDSPKSPNPNLNNSEGFPRSSSRTSISSLSGLTAKDEEGSINMEYLRNVIIKFLESKSTRAQLIPVLTMMLKFSPEEVKRLQHVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7T4</accession>
    <name>A0A367J7T4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001959">
        <property type="protein sequence ID" value="RCH86022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7T4"/>
    <dbReference type="STRING" id="86630.A0A367J7T4"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH86022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="33514" checksum="97A60EBE30881B89" modified="2018-11-07" version="1">MSDHEDVDALFEDDPGPLEEVIDEDDAEDLKLDQAENKVWLVKVPRFLSEMWKKIDQENVRLGSVRIYKDSAQQGKSSVSLVLPDNETTATIPKEYSINFISTDVQNKFVFSQSDHGKAISGTVYHEGVAVPTETNAYRNIMRKRVMEAGTPQRTTQVLGQNNQPIFVPGASSTVPTSDFSDFVQSKKPRLDKEKATRMPRNELMDLLFAAFDRYPYWSFKGILEETKQPSQYLKEILNEICILNKRGPYAGNYQLKPEFKQRLSVAEKQNAVEKSPEEATSSEDEEFMEDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J836</accession>
    <name>A0A367J836_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001948">
        <property type="protein sequence ID" value="RCH86065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J836"/>
    <dbReference type="STRING" id="86630.A0A367J836"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="16345" checksum="42298797D9003DEC" modified="2018-11-07" version="1">MSNSRSIQITQLTNKTISKEHLNQLVCLVQQQLSSSTTKESVLAALSSTQSVILGAFSDDILVGTASLVYSHCVTGTRVHIEDVVVDSEQRGKGIGTYLINETIDRAKKLQAKSIDLTSRPDREAANKLYRKLGFVQRETNVYRYASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBC1</accession>
    <name>A0A367JBC1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001705">
        <property type="protein sequence ID" value="RCH87206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBC1"/>
    <dbReference type="OrthoDB" id="2264760at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="324" mass="36243" checksum="542F15C0004EC931" modified="2018-11-07" version="1">MPPSRSSSEPTLNTLAEMIQKLQDSCMYGFIDTRRDFASEIKDLKDRISLLTQENAALKAELTELRKVIGTTSTITPAVQNTATTTDTTTTIATTKTGLFADNLFPERNIPIPKVSDTRSDRKERSIQFNWKHYRWLINQVRGPDVEEIDDRTFEVCRMNVSSKIVKAAVDSTKRTFNLGDDLSWGSIPGDAQIAAIEKLEDMAAPFIPLRACAGYWGANILLSYYWTTRRRTEKKKATISNQENATTSNTSSQSDEPHPVVSDPSPSVDAEENETVDLDADQLPAVSITPKRTLGKKVSSKRSSKFSSKRRRVAESEANEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCH4</accession>
    <name>A0A367JCH4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001618">
        <property type="protein sequence ID" value="RCH87630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCH4"/>
    <dbReference type="OrthoDB" id="2262790at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="125" mass="14623" checksum="2D599BBA7E49D283" modified="2018-11-07" version="1">MPIKGVYHYLVCRDLKASENNAVEELAEFDSFLSNETDLTYKIEPSTHYTENLKLKQYVLTFHEVNTYEERHEVYLYDDDSILNERFLISIKLEGISAINFNATLPHNYKRAPVILKANTTCTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD65</accession>
    <name>A0A367JD65_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_009094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001575">
        <property type="protein sequence ID" value="RCH87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD65"/>
    <dbReference type="STRING" id="86630.A0A367JD65"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="135" mass="14926" checksum="CB19D242021EF7AF" modified="2018-11-07" version="1">MSRQFGSRSVRSYQNLHNRTALLGDAKYDRNTPSPSREFDSVKVKMNDYELDYLESQNDEDISGLSAKVKILKNITGKIGEEIKYGNSLIDSMNSQFSNTGSILGLNITGTEDVVGIRWYAECGGIFSCTLVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD78</accession>
    <name>A0A367JD78_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001565">
        <property type="protein sequence ID" value="RCH87922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD78"/>
    <dbReference type="STRING" id="86630.A0A367JD78"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH87922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="351" mass="39878" checksum="B6AAC60EF27E6C37" modified="2018-11-07" version="1">MSRTPVTVPCKYKTGRVLGNGTYATVKEAMHIETGKYYAVKIINKKLMEGREHMIRNEINILKRISQGNKNILSLVDYFETLNNLYLVTDLASGGELFDRICEKGSYFEKDAAHIVRTICSAVAYLHDNGIVHRDLKPENLLFRERDENSDLLIADFGLSRIIDTDKFHTLKTTCGTPGYMAPEIFKKTGHGKPVDMWAIGVIAYFLLSGYTPFEGANNIEEMNAILNADYNFDDPCWDGISSQAKNFIERCLTIDPDKRITAHQALEHEWLAEKEIKDEEHKKKEDLLPNLRTNFNARRTFKKAINMVTLSNHFGHLSKHNSHSNALDQLKPVNEGIDQVLETSEKEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDA5</accession>
    <name>A0A367JDA5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="7">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ALG7</name>
        <name evidence="24" type="ORF">CU097_004413</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dpy-30 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001559">
        <property type="protein sequence ID" value="RCH87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDA5"/>
    <dbReference type="STRING" id="86630.A0A367JDA5"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016719055" description="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" evidence="23">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCH87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="496" mass="55575" checksum="F2730996D352DCC7" modified="2018-11-07" version="1">MKIVPLLLLVTVLATNWALQKGHAPLAASVVMSTVACLITYITLPKLKETFIKAHLFGRDILKTGKPIIPETMGLPTAIIYLITLYLFMPFPFINSFYTLSLDKFPHHKLGEVLSAILAIQSMVLLGFADDVLDVRWRYKVWFPALAGVPLLMFYYTNGGGTSIVMPMQLRPYFGKIVDLGALYYVYMCMLIIFCTHSINILAGINGVEAGQTFIIALSVAVNDLLYVVNSHSTPSSEVHLFSLYFILPFVGVTAALLWHNWFPAQVFVGDTFCYFAGMTFAVVGIMGHFSKTLLLFFIPQIFNFIYSCPQLFRFIECPRHRMPRLDTDTGLLKCSTVRPNDKKPLSKLGSLILKLLNAIGLLKVFEYDDNGRIIECNNLTIINLVLARLGPIKTEPTEHAPLTQPTNPIKQEEFNNSFIQYTPENIVEQLEQSATPVSKVKQPVVEGTVSPRAYLDRTVVPTLLEGMKLLATERPSDPLAFLGHFLLSRSNEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDM7</accession>
    <name>A0A367JDM7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001542">
        <property type="protein sequence ID" value="RCH88034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDM7"/>
    <dbReference type="OrthoDB" id="2289008at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="224" mass="26637" checksum="7FBBF048BAC0DA1F" modified="2018-11-07" version="1" fragment="single">VFKEVFYAQENHDLPVRQSDLSAWRHLARLCTLFNCQHFKKFISMNRLGFADFHAKHFGPEQQEYWKQFLRNQQQYYQQQSDEQSSQLVSDYSYYYNHDNEPTDLEEEQVEADENYDDYGLSKEAIEIFRFSEAYRKERDEERLKQEEADQVGKEDWKFDESSVMCSGGSEAPATCLVLTQKNRQQSENLRMKEDMLNSEYLSSCTNKDTDTPVVLWPVLPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEA2</accession>
    <name>A0A367JEA2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TALE/TGIF homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001497">
        <property type="protein sequence ID" value="RCH88273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEA2"/>
    <dbReference type="STRING" id="86630.A0A367JEA2"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000059">
        <property type="entry name" value="TGFB-induced factor homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="111" mass="13183" checksum="E630351B0165D211" modified="2018-11-07" version="1">MVHSMLKSNGKLWSEYRIEMDDDDIGSISSQIKKKRRGNLPKSITVILRQWLIEHCHNPYPTESEKKELKQKTGLTLNQISNWFINARRRLLPQIIEGSKRHHRKIHSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFB2</accession>
    <name>A0A367JFB2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_001372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001435">
        <property type="protein sequence ID" value="RCH88614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFB2"/>
    <dbReference type="STRING" id="86630.A0A367JFB2"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="459"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="622"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="86675" checksum="270133B29F18F913" modified="2018-11-07" version="1" fragment="single">MDIAFNIHELTTAAQKGQREDIQTKTSVIVESIRLMLYASRALDKDSHLLQDPAFKDPRRLVMSSLSKLVLNSRLSTELSDPQTTAVMLEKIQKDANDVLVAVRNFVTICQQRSVNISNVSPRLLKDTSQLPFDVFSFDNQKNSPTAASIANDLSNLNMNSDKKRKGSKQSTEQSSSLQQKTRYLLNQDLVVSLQVYSHQIYTSAEELSANAHNILTEYNKDRSLKCMDKRASSVSLFKALSTQIGQYIAILDDINLDNIDDNQIPSIVTYRASRQSIYSAIGHLFGAVQTLTDAETIIPDAVDLINQAVIDIENVIETVEQSVIAMVNERKRNMGANREEHLTLSPTTSTSASGIRRSPSRTSFSDSIIDHHSDIGTFMTSTSSKSQEGASESDFGDFSLPPDDVKTLNFRRPTLGMTGISDIVNRRRQQSIRPDDRAGDLADTLGYDHQPDEIEIGSDGSIKGGTLPALVERLTVHNTLDTNFIATFLLTYRSFCTTEEFVTLLENRYNLRPPERLTPEQLALWTERKQKLVRLRVFNVMKNWLENYYIDEDEYLLGRFEHFTKSYIRDSSEFAANQLLKLIKKRIESRGEIKKIIRNEVDGPVPIRPKNMSNITLLDTEPLEMARQLSIMDFKLYSSIRPIECLGKAWSRDGDHGLVAVNIKQSIKYCNRLTSWVTESILAHEDPKKRATVIKYWVQVADHCKVLNNFNTCMAILSAFDNSAIGRLKKTWMACNRTTTQTLASIRKLMGANRNFVEYRENIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFD0</accession>
    <name>A0A367JFD0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MNR2_4</name>
        <name evidence="8" type="ORF">CU097_010552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001429">
        <property type="protein sequence ID" value="RCH88653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFD0"/>
    <dbReference type="STRING" id="86630.A0A367JFD0"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="512" mass="58935" checksum="0D255CB5C62E36D0" modified="2018-11-07" version="1">MAKSKKRSHKGGHNKRQNINNTDDAPSTFQPLNIFFNRNNGYESIPTEDDHPAIEDITINMSGANSPRYHSDIETSSNSRLSPVEVDVCFPTTTPDKKEEELVGIDYEALEEFVLHEKKESADMTKTKTRPRRLSTMGPSDNRRYSMYGDRMMNMEPSESGGDQYRVTYYSPCEPSTIHSRCISEISEYKDGTLSDMLKKGCFWIDIYNPTDMEMRALCKVFRIHPLTVEDISMEEQREKCEVFMNYYFICFRSFDQDEFSATYMQPSALYIIVLKEGVITFHFKPMPHPHNVRKRIKQLKDYINVTPDWICYGLLDDITDSFAPLIRAIEFEVDSIDELVLILKESEQSDMLRRIGYCRKRMMGLLRLLSSKPDVVKTLIKRGEIVPEDGTRPALSKEVALYLGDVQDHILSMLQSLNHYEKISSRSHSNYLAQISIEMTQTNNEINDVLSKLTALGSVLVPMNLVTGLWGMNVQVPGQYQEDLTWFVGIMTSILAFCIVSTLLMRYYNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFM5</accession>
    <name>A0A367JFM5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001412">
        <property type="protein sequence ID" value="RCH88758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFM5"/>
    <dbReference type="OrthoDB" id="10501571at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016919082" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="105" mass="10436" checksum="DE9299697C1CE0FE" modified="2018-11-07" version="1">MRSSFITLTLTTACLLGSSMGGAIYAKRDLGLGETVGNVGTAVGGTVSQTAQDVGGGVDQVTQNVGKSVGNIVGRGVPDDAPWNGVYGAQDTTDATSNLGDSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHI2</accession>
    <name>A0A367JHI2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001336">
        <property type="protein sequence ID" value="RCH89171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHI2"/>
    <dbReference type="STRING" id="86630.A0A367JHI2"/>
    <dbReference type="OrthoDB" id="408760at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="26228" checksum="9434E0DEB45963A8" modified="2018-11-07" version="1">MFRAERVKVLCFGDSITKGYCRYGSEYYPYSIYLEQMFAQDYPSLQIDFVECGRNGERVVKQMEKRFKQVLDQNRYDHVILLGGLNDMADMMRNQSTTKDILCAFDNMYKTIEDNKCIKSFIHITVPNCVLDCKHHGDNPYQKQKDIVSDAICNMNSVKKRIVLDLRDHSSYQMNSLCMDEQLHDVYWDDGLHFTKEGYMLLAKNIYKLLKEEVINTHALLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHI3</accession>
    <name>A0A367JHI3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_005516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01001295">
        <property type="protein sequence ID" value="RCH89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHI3"/>
    <dbReference type="STRING" id="86630.A0A367JHI3"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="269" mass="31269" checksum="0A497E21BE984FA9" modified="2018-11-07" version="1">MVDTQEETPKCPVDHNAYKHFIPQENQQVEEGAKCPVDHNAYKHFTPQKEGSVKEPDSCPVDHSARQNFIPASKEGCDSDAIDSSNYMPKVSEQAPQHDQRLPLGKERQISSIPRANSSEKMWIYPSEQMFFNAMRRKNWTPKEEDMSVVVPIHNAVNEMAWQKILEWERMHETKCNQPMLLKFQGRPKDITPKARIRSWFGYSLPFDRHDWTVDRCGEKVTYVIDFYTGKKDPKNPISLSFYLDVRPAPTPAGIWDRIKMSLRKGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHW3</accession>
    <name>A0A367JHW3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001284">
        <property type="protein sequence ID" value="RCH89459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHW3"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH89459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33657" checksum="2686C046D2AF7BAC" modified="2018-11-07" version="1">MQPIFQTTEMVKGSRECVPLDDKTTLMITIFLCFGIVVSYLPQHYRIIANKTSEGFSAWFLLLGVISSSSSLLNIIVLQWDAIVCCKSLSTGACLEGLMGIVQIGIQWSMFCLVFLLYLIYFPENKKREPHAPTSLHLEFPNKIQPPISAEWKMSLLVATLCIGHLAISFFISVLLLIIVGGPEHWLTNYWAGFLGVLSMLFASFQYIPQIWKTWNSKVVGALSIPMMMLQTPGTVLFMYALIVRPGTNWTAWIPYLATCILQGVLLTMCIAWHFRNKRLNISDLDGAPEPTEATRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI62</accession>
    <name>A0A367JI62_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001256">
        <property type="protein sequence ID" value="RCH89617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI62"/>
    <dbReference type="OrthoDB" id="10313279at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016776682" evidence="3">
        <location>
            <begin position="23"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="697" mass="76875" checksum="0854ACD8FC46099A" modified="2018-11-07" version="1">MMTYGPKLTIVITLLFCLLINGYKIVYCDDNGCMPQESLSILESPPSSTSLPSPISSSGTASPLQTSFHEAAVVHATSGISENASSDSRNWKIIIGSIGGILGAALVAAAIFVVRYIRQKPPVLGEADVGAFSTDNDRHPISSSNLKAAEQEKGVDGQMKTAKNDRHVDAVCVIPMDDAKTSLLNMELKQLMKAVYQKGLHNKSPQELQSKKKNKATTSKGDIKKNSGMKQEEASNQQVACDQEDSCNQEKHSSQEQNVTSIQGDQFTSRISRALDLVGSTPNQLISITKNGVPYLRSQSMPNLALSHVRSPAQPFADSSKPALDPLLISRSQEPIKIDSAATSNLPWLTMSNIFNHLQQPVPLGEGNISTEEEGRELENEKNKEETSTEKSQEVAKEGADEEPLIRRFIRETESLEQAELSPSVIELIKQCKIPIGLPKNFREKCVPVHFRIYGLERMEREKVKIEEINKLVPYVFDGPNKHHYPAQYHHVLEREVQRIKNRGKEPVNEKVPLPPVKKKKSLSFSFWQTKPKKFTTAMIRRTDISLEKPNTDPASTSSKSVNDAQQDKQVASTSYDSSSQTDTVNTGLIQSTQRISSSLQVPNRIDSSGSLGMQENEISLQVIDKVMDMQTISPAFADIPADLIPSTINSNTTKDTRTISHSPAEPGSPLAARTIKHYEDAIPHTVRRLLNPPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJC6</accession>
    <name>A0A367JJC6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001186">
        <property type="protein sequence ID" value="RCH90043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJC6"/>
    <dbReference type="STRING" id="86630.A0A367JJC6"/>
    <dbReference type="OrthoDB" id="10291696at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="510"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="614" mass="71297" checksum="0ADAC87661EBD5AD" modified="2018-11-07" version="1">MPKENHSNQCFMSVETNDDCNENTNHLFQYTSTNNVVALDDEYNSEENDSERKRSYIDDSGMFHCDEDLKEEEYQQESNSKEELYQKGLDLPPLKSFLKSAIESKNTLSQDKNDASIYTQLMSSLDMTTRKLHNEYSISCFEDHRSEHKLSSSAPSGYDYLDEYRELQMLEMQKYFQLSASAPASQMANEDIIDEEHEPISDMNDFCNNELVVTANESQTCSITMQGQQTVQSDENEYDYQETTAAKDDNRELVDDHNLSWKELADKCYGQTEDKLSLSTVDPNNPFLEVYFERMRQREYPFSSGGPPYIYINPYYMPYQSCYTAMSTDYTPMEQPRNHESFIMEVTNIAGAVKLKHLYELFFDPNVLYHRDDYTAFVCYQSLDSLTAAVGQYYGRRFMGKKLHCCAHMRENFTTWTSLGTQTTECTMEPSSSTSSYVGNRSDAEKKNSKAHDGKQKKHFSFTIHDEKSPTTKQERTQNKPESKRENRRSDKKKLASINADCFWRPLRSSEYILATSNTTEDLIFAKATGYWSVDDFHVDFINTLFTSCKNVYLIFIPQQADYISGFGKITSKAQPIHSMNLKNTPFAIKKSEFQIVKEGRNWRNILKIRWINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKP8</accession>
    <name>A0A367JKP8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycoside hydrolase family 31 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001109">
        <property type="protein sequence ID" value="RCH90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKP8"/>
    <dbReference type="STRING" id="86630.A0A367JKP8"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06594">
        <property type="entry name" value="GH31_glucosidase_YihQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052990">
        <property type="entry name" value="Sulfoquinovosidase_GH31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044112">
        <property type="entry name" value="YihQ_TIM-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007746">
        <property type="entry name" value="PRK10426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959:SF2">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="97"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="310"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="656"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="87842" checksum="FE558D49F66AB88A" modified="2018-11-07" version="1">MWASVAKTLGLTSPEEYVKPRLSIGNAVAHQEFSIGHFKIQVDPEAIALVVKNGNGRVIWKSIHNEPFLSSTIGTDDIITEGNGVFKVTERNERSTRIQTITKVEKTDKDTIKIHGGLGAKLVLPTHMDYVFTFKEISHRQLQFDVQVTHRDPSMKDFRRLILTYESRPEEHFYGFGEQFSYVSLKGQKVPILVREQGDGTGSAPAATIKETAFNMFGGNTDNFATYASIPQYITSDVRCLFMENSEYMSFDLTELDRVSIRIESDHVKGRILDGKTMLDLLTDYTLYTGRMLHLPDWTSEGFIAGIQGGKEKVKDVIKRLKEKEIPLAAVCIEDWTGQRTLHAGRGIQFSRQWWNWESDDEQYPGWDSFVYELESDNIRVLSYVNPCLSNISGKGKFKKNLYAEAQDKEYLVKSTQTSSSDAKALSLKFGLSLEAGLLDLTNPDARDWFKNVLKEQVWSSGISGMMVDFGEQLPYDPSTIILHSNEPSSSYHNHYPEDWAALHQELIKELGKEEDSLCFFRSGYLHSPQYMNLFWAGRQNVTWDQHQGIKSAVIGMLSGGFSGFSVTHCDVGGYNTVVNNIPGFKMLRSKELLLRWMELAAFTAVFRTTEGIIPSMNSQFYDNDDTYAHLAHTIKLFTTIKDYRKQVLKEAYEKGWPLMRHPVLYYPNDKIARELTYQEFLLGSSLLVAPVLSPSASYVKVYFPKDAQDVLWRHIWTGKYYPGDGTYKAIDAPLGQPAVFVKEPRDDDGLLNGLLNYATTYYQQKARPPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKU8</accession>
    <name>A0A367JKU8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001101">
        <property type="protein sequence ID" value="RCH90574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKU8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="116" mass="13457" checksum="6521E53D39831DCB" modified="2018-11-07" version="1" fragment="single">MTERKSRRLAEKQETSRSKSTDRQSYISKSASRTRNTESIERRGTRTRRTTSKVVVSVTDDETDFEDDYESEEEIKKPKKRARQITKQPSKRNAPVKQKPAIAPGRTIQRVNRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLP0</accession>
    <name>A0A367JLP0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SNF1</name>
        <name evidence="15" type="ORF">CU097_007404</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001058">
        <property type="protein sequence ID" value="RCH90852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLP0"/>
    <dbReference type="SMR" id="A0A367JLP0"/>
    <dbReference type="STRING" id="86630.A0A367JLP0"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH90852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="566" mass="64349" checksum="647E617CA9BD71EE" modified="2018-11-07" version="1">MSNNNNNNNNNNNNRIRIGQYNIISTIGTGSFGKVKLAVHAITGQKVALKIINRKKIASMDMSGRVKREIQYLKLLRHPHIIKLYEVITTPTDIIMVIEYASKELFNYIVEKGRMSEDDARRFFQQIICAVEYCHRHKIVHRDLKPENLLLDANNNVKIADFGLSNIMTDGDFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCGRLPFDDEYIPTLFKKINGGIYKMPSYLSPDTKQLLTSMLVVDPLKRITIQEIRQNAWFNKNLPDYLRPLPNTEENENMPIDDALVSELSKKMGYSTETILKALKEPSNNQFKVAYQLVLDNKTLFKDTEHNNIPSFLATSPPPWNTSLNTDDINHEDESSISVLSSSLPKAEPIGRERSSSIASLRADLPIIYATGTPPPGAMAPPSRSTQPRHLSINAATKKPHKSRSKWHFGIRSRCPAWEVMLEIYRSLQNVGMEWRTVDPYHLRCRYKYTELGLVVKFDLQLYKLENNSYLVDFKNAGTKRLDADGKEIKKVSQGPFWQLDEEDALAEHMQSVYPFLDVCSKLITDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMA4</accession>
    <name>A0A367JMA4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSB6</name>
        <name evidence="10" type="ORF">CU097_008375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001025">
        <property type="protein sequence ID" value="RCH91072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMA4"/>
    <dbReference type="STRING" id="86630.A0A367JMA4"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="225"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="716" mass="82176" checksum="090C87F4AF1347B1" modified="2018-11-07" version="1">MPQRTPRNAAYTPLHEDEEDENTILLLVHHPNSVLVANHHGECHVVPHLSQNLQPTPHSPTKSSFSEATRRFFQSKLPIVLRKDMAITAASFASLPPVIIADLQNGNMPTTTNVNELGWAIVRRKRYRGKNGVGETRHHHQTKSPTPSLFDIVDEEIDPSDQVTCSIFVKWEKTEGTDTMTMSPLLNELTKQNKKEDRHFKDPIPVTSEKFLEIVQSVRIAIENNMQPTRISQGSSGSYFCRNMDGKIVGVFKPKNEEPYGRLNPKWTKWIHRHLFPCFFGRSCLIPNLGYISEAAASLMDRKLGTNIVPYTDVIHLSSSSFHYDYLDRRANRRPPKIGSFQCFLTNYKDATVFFKSHPFGIEKAISSRGSTSSLIGGRAVWGGCLGTTDEVQDDDEADDEGEQSDSTRKNSKQDEGQFRWSMQLQNQFRREFEQLVILDYLIRNTDRGLDNWMIKYCPGKKKKKGSKHSSYSSLHENEDGDEQGHIHVAAIDNGLAFPYKHPDQWRSYPYGWIAMPDSLVNRPFSEATRNQFLPILSDPLWWRETVREMRSLFELDDDFDEKMFQKQVAVLKGQGFNIIRALKDPSSGPIDLVAMERIVINQEEIVIEFNEKILQSRCEFGKNKRSNSLDAISNIDTRTTPIERDQTWKQKVKSRLSIDIGRSGSFFNKKRKSHDRAFDSDGDFSEDEEEVVLKKVTVIMETIELVKSRTYFTCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMT9</accession>
    <name>A0A367JMT9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000998">
        <property type="protein sequence ID" value="RCH91252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMT9"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="213" mass="24710" checksum="6DC9B7CCC9ACFDB8" modified="2018-11-07" version="1">MDHTLSGWLFKLSTTNKLGSSKWQSRYFVLLDTELRYYKHEHSVDPSCAISLHEVSRVVKTSTFNHNYCFKLETTTNYKQRHAKRQKTWTMECHSEYELDVWFQAINARLTKLRQYHSLPCPSNVKPRSFKRSNLSISRRRGIVLSPLEFESMPVLDHETLSSSSSSKASTIPSPNINTSETYDSIIQQGCENQAANFIMQHDYTSSSKQFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN20</accession>
    <name>A0A367JN20_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centromere protein I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000985">
        <property type="protein sequence ID" value="RCH91327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN20"/>
    <dbReference type="STRING" id="86630.A0A367JN20"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="72670" checksum="4667AA02212E519E" modified="2018-11-07" version="1">MANRRDNTDEDQMSDHDSIYSNDQDIQSRAVSLSDITTDNVDDILHEQFNRFHPSLPAATLVHNTPYFLSSGDIIKKFGLSQIQFEALYQIIMSNKLVPRRRIALVSLLLPRNNVPEWCVTRIIARIPNNSVKLNKRLLQWIISIYDMIESDNEQYNNLYPVLFHYLTIAGIRTELCHLLYYMTRKNRVTKYRVKKLKEMIDKEKDNIALIALLMVYKSYDDSIEISENVRLRGAIAFEHPDPETKNNLMNIRMLWSNNDETGLYRPPITLGSTSVPRNKRKRNQDPQELKKATIQFRNLDVQEVLRMAEHIDQFKLSEQLDRMLENRILQHVIVCRPDSSLISRMGYWLDQKLLYLVRWANPKDIGKTEFREFLQKLIKLTQFTKAQLPIIEDFLREYLKIWNGYEFQEEVFELVTFLKPNEYQDLYKSVLRPLYRFEWLKNWALLDWDKHKKLEQDEQAEMDQVTWLFKGLSFDTDYFHSMQQFVLHVDKLCTLGLLQEKDHPLLQHASLSFFELVSSISIQHNIPRIITPAAPFVYRHFFSTSAMAHSRICNIIYQYKMAFEQSEDQLEDHQTEEYLSSFNTCMLNVCNALWKTISIQGEQPPFDLPAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPR3</accession>
    <name>A0A367JPR3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000908">
        <property type="protein sequence ID" value="RCH91875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPR3"/>
    <dbReference type="STRING" id="86630.A0A367JPR3"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017057591" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45500" checksum="DC1E33BA80AE0534" modified="2018-11-07" version="1">MFRHPPSLLSFISALLIANVSGPQYVYPIYGSYLYKRLAWSTFEASIVSTACFIGVSFSGPLCSWSLERLGVKRTLRLSSAIVFFGFFLVAQTYAGRLPNHFLLVTIYFILTGFAGAASFLCALDCQSRNFKQHRGLAVGMTTASIGISGLVFSQINDTLFKLEDIAIDVTLTEDATYHFLIFLAISMSLGILTGSFFLNSVDYRPVAVLPTTDQPEPKSGIQFLINPIGFALFCTLFVTLGIGYVYLANIGQILQGTHPVDLQHIRNSHITLFSLGNCASRAFFGALGDVLHHKLGISRLWIFVFAVLSLIMSLHHLSDLPEDLTPYTLLISMTYGISFGVAPAIITDIGSSHKAFARNWGWMLYAPALGSQFYNILFNSFDIYQIGQWSGWAILVVLLLVIYQQRTIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPW8</accession>
    <name>A0A367JPW8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000891">
        <property type="protein sequence ID" value="RCH91993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPW8"/>
    <dbReference type="OrthoDB" id="10314391at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="176" mass="20419" checksum="8CBAA3E586CA02D0" modified="2018-11-07" version="1">MTFSERCLMSLDRWDNANIQKLYSVARGICNDKQNTNRKSLVAFQVISEVHERQYTKIKDWLLKAPPDISKSMQYIKDGISYSRRLKQKYEAALHEEDHHEESVTSIEEPPDIPSSSTCTVDTSVMQSVEAYIEKSNGRSMDWKNCFSTGVEQGFIKGYATKESLRVVYSRYKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPY8</accession>
    <name>A0A367JPY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycogenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000889">
        <property type="protein sequence ID" value="RCH92013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPY8"/>
    <dbReference type="STRING" id="86630.A0A367JPY8"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34778" checksum="EC3274C6DAF3F566" modified="2018-11-07" version="1">MVTKYKAAWAVVITSSNDYIKGVVTMKYALHKVHNSQYPLLILYTSHVKPEIVEMFKNIGCLVKSIDAIYPSGKVDYQFKRFSETWTKLAVWNQTEYDRLVLLDADMLPVKNMDELMSLELPQDWVAASYACTCNPQKIKHYPPHWVPENCAYTGCQSIQPSPISDRADYFNSGLIVLSPSKDKYDNMINYLNSMEDLTVYSFPDQDFLNEMFKNKWKPISYVYNTLKTLQWAHKPMWDMNQVKNIHFILTKPWDLDINQLSDLENTYRALYKLWWNYYSEACNNMGTSKSLDRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ49</accession>
    <name>A0A367JQ49_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COP9 signalosome (CSN) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CSN12_2</name>
        <name evidence="3" type="ORF">CU097_010578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000880">
        <property type="protein sequence ID" value="RCH92073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ49"/>
    <dbReference type="STRING" id="86630.A0A367JQ49"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="214"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="47676" checksum="D7C609DC459F04A4" modified="2018-11-07" version="1">MYRQKTAYIESFLQKIKKNSQEERGKPLAALFAYSEKHVDQLVSHNLRPQELQELINRAQLESPWNDIALHHIRTAINLDQEDYEEAFLSQKELVQSFQRNMPNFTRWVLPVLYVFNNDLRLIATRADQDKEAEEGQRRKLEEAANVISKSFTGCITDRSVMSLSKKYGTYRMIGMLFRIYFKLKQQNLCKNILRAVKAADMPPIEQFPKSDRVTFRYYLGRLYFLEEDYAKAENELNLAFRECTNRHVKNKELILQTLLPIKLMKGVLPTQALFSQFPEARHIYSDLAAAMKKGYVKAFNEALSKSEPTLIKQRTYFAVEKAENIAIRQLFRKVYLLMGQNTRLPIGKFKQALDFEGMNVDIEEAEWMLANMIYKGYMKGYLSHEKMFLVLSKDNPFPSVGQVSNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ50</accession>
    <name>A0A367JQ50_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000880">
        <property type="protein sequence ID" value="RCH92072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ50"/>
    <dbReference type="OrthoDB" id="2225686at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016619885" evidence="1">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="128" mass="13878" checksum="C49CF557FA1A7941" modified="2018-11-07" version="1">MALLSSALMMNCSLLIYPLVLHLLPQAVQVESVSRKLCACGIGCDIYFTASPRQISGRTRSKRHTTFNHPDALEHGGSLGALGKLVRGSLSKMQAKLSLKALAQEGNEFKFVKALSALVTRPILDWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSM4</accession>
    <name>A0A367JSM4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000759">
        <property type="protein sequence ID" value="RCH92954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSM4"/>
    <dbReference type="STRING" id="86630.A0A367JSM4"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="581"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="934" mass="106201" checksum="1A7055F9A307C311" modified="2018-11-07" version="1">MFRAVSCNIVKKPRSGRVLLRNTRYYHDDGVYGYRVPKEFKLPDYTEQELANRSQYGSLLRMVQAYRTHGHEGAQLDPLNIMKRKEVLALKPERYGLGKDDERYNLAGILHTNDALQENTSGGEEADFKTILNHLQAVYCGKIAYEFMHIPSASERRWWYHAVESWQKPELTVDQKKRIHELLVNSEVFDQFLGKKFPNVKRYGLEGAESMMVALDRLFELSALNGVQDVIIGMPHRGRLNLLCDLLNYPHAALFHKMKGFSELPEGTFASGDVISHLTNNPDLEYHGKKVHVSLLHNPSHLEAINPVAMGKARAKQTDRLATADSSCNLGDRVMCIQIHGDAAFTGQGVVMESFGMSNLPHYSSGGSVHIVVNNQLGYTTPAQNARSSAYCSDIGKMINVPVVHVNGDYPEDVARALDVVFEYRNKFRKDIILDLMCYRRWGHNELDEPAFTQPLMYNNIRHRTSVPKLYEKKLLQESVLSGENEVEAVRQRHVEMLEQGLQEAESYKPSSNYHLDGNWRGIEHIKEQPEEQVETGCDVELLKEIGKYSVTPPEGIKVHPRLQKYHIEQRLKKLSQGHSLDWATAEALAFGSLMKEGMDVRISGQDVGRGTFSQRHAMFVCQDTERAVVPLNHMENVKSHFEVANSPLSEFAVLGFEYGMSLESPKRLVLWEAQFGDFFNGAQIIIDTFLSSGEEKWLRQSGLVMLLPHGQDGAGPEHSSSRVERFLQMSNDPFDVNKAHRQAANWHIVNCTTPAQYFHVLRRQMLRQYRKPLVVISPKSLLKSPVAVSNLDEMGPGTRFQPVLGDNTIENTDQVKKVVFVSGKFYYDLVKERERRGMKDRVALIRIEELSPFPRNELKKEIEQYGQADEFVWCQEEPQNAGAYSFMAPRLSQLIPKDKVIQYVGREPLSAPAVGISSVFKQQASKLLEDIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT10</accession>
    <name>A0A367JT10_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000747">
        <property type="protein sequence ID" value="RCH93058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT10"/>
    <dbReference type="STRING" id="86630.A0A367JT10"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="289" mass="33045" checksum="71184F4BEA871E19" modified="2018-11-07" version="1">MVEYQDSAAVVEITNALNTKREFHNDETSTYWLPKDDEEQMRLTGQHFIFKELFEGVSEALDFEKGVTILDVGCGSGVWVMDMIHDHPNCTYYGCDIADAVNKKMDYRQFTFTRANVTNRLPYEDNTFDLVHMRLFIAALREDEWPAAINEVLRVTKPGGMIQLMEYDPKLPKDPTNIFYKTVAAFRNICESRGQNPNIGGELVSLLSKYECLKIIQSEYKAIDMSSGTPMAKRLIWDVIEAFKSMQHVMGPIVGVKSNEIGQFLIDYEHSLQTKESFICFSCVAVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTF1</accession>
    <name>A0A367JTF1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000726">
        <property type="protein sequence ID" value="RCH93217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTF1"/>
    <dbReference type="STRING" id="86630.A0A367JTF1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30409" checksum="03C40A060B945D0D" modified="2018-11-07" version="1">MTDIQLPKTDFVLLSIPEPHILLVTINREKQYNALNVAANWELHHLFNWAEEQDSIWCIIITGSGSKAFCTGMDLVSAHESKKKDTSSFGTTDLPPTGFGGISNRRKSRKPIIAAVNGFALGGGMEMVVSCNIVVATEKSKFGLPEVKQGVVIAAGGLARLARSVSYQVASELVLTGRFMDAKEANKHGLVNEIVSNDTNVVDAALQWAKKITANSPDAVFLTKQGLLLSLELASVTDATDEWLQTPEAKAWREGYNLGEGLKAFSEKRKPQWKIPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVL6</accession>
    <name>A0A367JVL6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000637">
        <property type="protein sequence ID" value="RCH93945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVL6"/>
    <dbReference type="STRING" id="86630.A0A367JVL6"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055105">
        <property type="term" value="F:ubiquitin-protein transferase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019516">
        <property type="entry name" value="Glomulin/ALF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430:SF1">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="575" mass="67298" checksum="9A1C83C478144A52" modified="2018-11-07" version="1">MTFFSTGHNYFTDGANTKYKEYTTEEANNFLNANEHDLTDLYNIKQILLALGQTKDPLTDERWFNILFKLISLLLINQETQANAYEAIEYLADRLDYDQLLEQLMDKLICFEWNHKDDENKCLAIAKEYTIYVELFGRAIEKISRPKEWMLYLPFLANNLQRTMESIEPILINKCALFQRKKPFSNWDQSVLLVVGCILDFTEFVHSTTVSQSPSDFRTDYDDIGLQDGDVKRRYLGYFLLNMVYGRVILNLDIQLSNKYFEKYYSKYSMKRSVEQQEDNEHILKLTQRCVTLANTYGFSYEKMFQLWNSIKRKQPYLSPDEEAIENDRQMINARLYPLNYEGIASLLSISLYNQLVSQHTIDLDAFDLAKTYIGILIHLMMQPSDRINTIDKAIFVALYISDKIHVNLNMEDIETIIEDPAEIGLGIPVTRIFQVVASVASTCPDASIRFFAYHLVRKFLAFGNEQVKVFLYQELLDGCPFPSMKTAAIGILKDQIDRSFQDDKSVFASPLVIDVFFPLIFRVNKDWSQRPSEFWNDYSHVMQALNLYYYLLLKDKHNKVSCDEVLLYIYSFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVX3</accession>
    <name>A0A367JVX3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ATM1_2</name>
        <name evidence="16" type="ORF">CU097_005900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000620">
        <property type="protein sequence ID" value="RCH94080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVX3"/>
    <dbReference type="STRING" id="86630.A0A367JVX3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="81"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="403"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH94080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="661" mass="73438" checksum="D088D07384154BE5" modified="2018-11-07" version="1">MFSVYLPFPSEKCRDPLPLLSLEQGGIKEKAATETAVAKAKQLKDAASDVKDRNATDWAIIKQLMKYIWPKNDIGVKTRVVIALSLLIGGKLLNVQVPFFFKNVVDSLNVTIPDDATLWTVCGAAIIGYGLARLGASAFQELRNAVFAAVAQKAIRRVALNVFSHLHKLDLGFHLTRQTGGLNRAIDRGTKGISFMVSSMVFHVLPTALEISMVCGILAYKFGTPFALVTFSTILAYTAFTVTTTAWRTKFRKEANAADNVAASKAVDSLINFEAVKYFNNEKFEADQYDKPLQKYETASLKVASSLALLNAGQNAIFSTALTIMMFLSAHGVIHGTMTVGDVVMVNQLVFQLSMPLNFLGSVYRELRQSLIDMDTLFNLENRTPLVVDAPDAKEFVFKGGEIKFENVVFGYHPDRPILNGVSFTIPAGSKAAFVGPSGCGKSTILRLLFRFYEPQSGNIYVDGQNIKSVTMDSLRKAIGVVPQDTTLFNNTIYYNINYGRIDATEEEVYDAAKRARIHDTIMELPDKYESKVGERGLMLSGGEKQRISLARTILKKPHILFLDEATSALDTHTEQSLLANFRSILRETGMTSLHIAHRLRTIADADIIYVLQNGKVVEFGRHEELLLVDDSVYKGMWTKQESTLAYFQEVNRHEETFKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW31</accession>
    <name>A0A367JW31_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000604">
        <property type="protein sequence ID" value="RCH94202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW31"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="10981" checksum="113550FB0A3A1159" modified="2018-11-07" version="1">MSESILLKDEVSLSLLNLVDDRKEVGWPAVLKDMKEFVVNHYDRKSLIRERGDRKRRFKAVATNMGFKIVRFNEDAWQAIHEALIILQIFHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW51</accession>
    <name>A0A367JW51_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_009957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nibrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000610">
        <property type="protein sequence ID" value="RCH94160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW51"/>
    <dbReference type="STRING" id="86630.A0A367JW51"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17741">
        <property type="entry name" value="BRCT_nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH94160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="799" mass="89086" checksum="37C380DD6BEAD0A6" modified="2018-11-07" version="1">MWYLKYSIFVNGEEQQCSKALLPGKEYTVGKRNTNIVIRHDNSISKKHVTIAVASMTVAGLEDVNHRPKLTVTDHETTYGTRLEGKLVQGSTPWHNEEIMQLGSLGFYMKVIWKPVIVCRNVVKSAEKKKLVKAAYQIGFNVLKKWNNQCTHLYMTELLVSDKLMHAMVTNRPIVSEKWLYSLIENGDVEEANRQTEPIVLKDYGPLRKTIELVYNPNRDELFDGIDFWIFDQGQYERIAFLIKLCHGNIRLVDMDTGIDVSDIKETTLFIQPPPELVASDRWVALEAQFCSNHGNVRTIPDAEIIYAVIYGSTHTMCNPRASFDINNQRTSPQSGTPGPSIPHNPVEPAASYHDDSRRQAISTEQQEADTVPFNPSVDTMPISQNNHGPKMTYRELQEADTVPFNPSATIPYSSSSIRRQIDIAPPHTSQTASTDDQTHSDIASNHVDTLAIASIPDHSKEDKVPYSSCQLHAHTSKSIQVKPDSSDAASEHKDDTLSQTPTAMLTDIFDLDEQIIPSEAKPELKSKLENGSVSKTSACSRSLPQVEAATLTLNVGDFFDDMIGNFDPLPAPSSPPPITSRLSEPSELEPTVSRDESVENRQQDRMEEDKTEEGGLVDTNTINVQTPPSLINETSTADVVFDQNEPVMEQHSATDITNESTIISNDAMIIDIPIDEAPDTTTAATSTAFESQATAHPQSDTVESTANTITPSIRNTENRDQVIYAPLVKRPRPVNTHIQQQQQQSSHGVVNYKRFRKTPQSRTSGNTRIVQTVGYNNRNEVEGKLSMVYELILSNLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYK3</accession>
    <name>A0A367JYK3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000518">
        <property type="protein sequence ID" value="RCH94975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYK3"/>
    <dbReference type="STRING" id="86630.A0A367JYK3"/>
    <dbReference type="OrthoDB" id="2412648at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016784769" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="24400" checksum="C6369B35E1BB0625" modified="2018-11-07" version="1">MRSAAFVTFAAAAATVVSAQSCNPTYNTPSAGECFAKCNESAGKTFFSDWTSDPASPNFLKSLSLMCSKGTAEYMAFMTKAGMCMVSCSNPDLFNQEFASACAWWEQHKNDSCGSSNGSGQTTTSQVAAATTTTTSQPAPTTQSVTSSQPVATSSAPNQNASAQAESSSTPAPSNSPSPSGVAPIGSNVQTNATAPAPKEPAASSSQSSASVASNHPASAASSLQVGGMVTVAATAVVVYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYN4</accession>
    <name>A0A367JYN4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000511">
        <property type="protein sequence ID" value="RCH95028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYN4"/>
    <dbReference type="OrthoDB" id="2228901at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="45121" checksum="3B21A788E4106061" modified="2018-11-07" version="1">MLSNRSERRAIQRAELKKLKKEEKKQALNGMNSNRFNSKKYPKASHPIQLAYKKRENMQSTDTFTIEYIHLAPSYHDTDQDSVGSLSSNELETALVSPEESSDEDLKDYPLADKLSGMELASAGTGYPLIDKENSGIIVVESTELEGLKTMSLHELTDSFIEDRHAVRDFQDQHDRLDKSTVLLECITMAETQGLNGTNKQSNDDGIMDSLDISFNKSTSAHDQNEVAIDGNTFGCQIINPLELTAEPEAWKSESSRISANDDALVDTISGSSDNQCTFLPLGGDDQEYMCKASCDTLGEETIELRGNQEKEVRAEAKTAQGKASSTPTLLLATPKPQNQATPSESQSYTITSLRGSNSIEKKKKSVFTRVFRKESKKEPKKTSSGTKTEEKAENRKKWKIWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYS2</accession>
    <name>A0A367JYS2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000538">
        <property type="protein sequence ID" value="RCH94801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYS2"/>
    <dbReference type="OrthoDB" id="2230748at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="225" mass="24947" checksum="329305ACED222DE1" modified="2018-11-07" version="1">MANVAIDAYKCLNVLALIGFLLNFIGDFVIIYPLWYFIIPGVFKLLLFLALCVVEFTQIPVYTKHWSFLYSFLGRALFYIVFSMVFISVTAIGFAGSIIIVFCGVVYLVLHFVLPGKEPAHMSYSTFLIIVGGSGNLPTANVNVQQIQLQQQHLPPPTANGQQYPFVHQSPLPTHQAVNPSPLPAHQVISQAPSPVTYHEQQHVASSPMQSPATYDSQEKVEVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZB8</accession>
    <name>A0A367JZB8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000482">
        <property type="protein sequence ID" value="RCH95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZB8"/>
    <dbReference type="OrthoDB" id="2372811at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57510" checksum="C33F07C9C39E061A" modified="2018-11-07" version="1">MSCCLDSSLTSLNNDDQASPSASPRLSISLDLPAYEGYLPTYWPGQSINGKLQIQLNSPVKVSYLRVALYGNVQVCGSQREVPLYNGLFDYHKNAQLINKGIRIMKRSSHDNAIGSESHHLEVVAEENHGAFNENESDHSHEQRHHVAPEKKRKKSEQDKQIERLIRRIADDDFDKDSSHGTFVDDSHLYDHSNERTYSLDGKKSNVRFSIGVPISQKLGGTFDHPNYPITYRIIAIMKCTTNNSQQHLTCYSTAKVRLEPYLDIHAPEFRSPLQSAQARLYLSGNNNVFKNICSCLLPNSLLIKPTSSTSNSHQTTFFSNSSYLLGHLEIPVQAFERLDAIPLKLKLINTCPSFKIYALKVKAQLTQRILMTCSFGEAAEYKTIMEKQILFNSNEHSILGSNGTLATLDTPKLSFDLSKLIHIPPGCVCSIPSKSTREIFSLVHDINVKLEIDGALLKKLKNDTISYEGLTQSENGGSVRQYQSNRKVYEMEIEPLPIIIGNSGYEIKQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0F2</accession>
    <name>A0A367K0F2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000441">
        <property type="protein sequence ID" value="RCH95683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0F2"/>
    <dbReference type="STRING" id="86630.A0A367K0F2"/>
    <dbReference type="OrthoDB" id="2237019at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="26001" checksum="FEAFCA33771F1435" modified="2018-11-07" version="1">MFYRVFSFKKLRINSIDALLPSQNNKIMFANTVKSDGFTVDFVINKRTTKDTSLAANVDLAPEDFDLKEVKQTYQPMFLGPGRKSVFTAAIGLDTTNHQIRRCSTAKYYHMTGSTKYIKKLEKLKTEKGIKDIENNITSAKTAECATYLSYIEYILTHVGTLFAFYDYKTAKDRFFMYQGRQRATEEMVNMLVHRGAKYNKKKRKKRKWKPAKFQMEREKVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K148</accession>
    <name>A0A367K148_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000418">
        <property type="protein sequence ID" value="RCH95933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K148"/>
    <dbReference type="STRING" id="86630.A0A367K148"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017082870" evidence="2">
        <location>
            <begin position="21"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="312" mass="32246" checksum="B7FD78A0544D0618" modified="2018-11-07" version="1">MRSAITISAVAASLFTSAFAANCNPSYNIPGSGECYTNCNIKAGQKFVPGWTMDHTSELFIKSLTVMCDKSGPNYGSFMTNAGICMAGCKDSNPEDFNKEFAGACAWWNVHKNDKCDSKTTTISTTTKTTTTTKAGSTSTSTKGNGTSTTTKTGSTSVNPGGSSTATSSTTTATVTTTTTSAVIDTITSCPTPPSCKSGYRGKRNGKGPEGACCSHSDDCQESCVKGKCNTPIASTCYSGSKGKRRGDGYMNACCKTSDDCWESCIKGKCNGPSLASCSTGYSGKKKGNGPKGACCSSSRDCQESCIKGICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1J2</accession>
    <name>A0A367K1J2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_011539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000410">
        <property type="protein sequence ID" value="RCH96017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1J2"/>
    <dbReference type="STRING" id="86630.A0A367K1J2"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016486741" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="168"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="399"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="53212" checksum="AC7FD19BE2412A66" modified="2018-11-07" version="1">MKYLITLVLAFVTLVQCSTIVARTQEEDVANGSPGAVCYADAYNDLGNNWNHTYAPTEPQQIHMSLADDSKFARVQFATLDSIDSSVLAYWPKKQGNYAQKNTTVTGKDWTFVDGGSAQRQLYLHNIQTKTLKPDTIYVYQVGAKKGNSIKWSKTYEFHTASLKKDFSFIATGDVGACNAVAVSHMMKYGKTHKYDFVTIAGDQAYNMADFNGTKGDEYLNFMQELFANVPYLGAVGNHESAYNFSHYKNRFNIVPYAESKFSNSMMYSINYKSLHLVSFSTEIYFEGSEQEIQTGINWLEADLKEANKHRDKRPWIIVMTHHPMYCSANSTDCTTKAATIRNGPGQNNQTWGGIEDILLKYNVDIFLSGHVHNYERTYPVAHGKVTSKSYHNAPSFFQLIIGNAGQPEGPAPFGNGPFPDFSAVRYEGYGFSTFKVSPTSLEMIHRKANLDGTLGGIIDHFTVTKDVHRHRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1Q6</accession>
    <name>A0A367K1Q6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000403">
        <property type="protein sequence ID" value="RCH96085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1Q6"/>
    <dbReference type="OrthoDB" id="5563272at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="67" mass="7766" checksum="825ABD5CA35360CC" modified="2018-11-07" version="1">MFQKIVNFWFSSFITERLLASPLFNRIAAKTHHHVSTITEKGAKTGGEFVKAFRENLEKEVRNSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K220</accession>
    <name>A0A367K220_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_010138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000382">
        <property type="protein sequence ID" value="RCH96292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K220"/>
    <dbReference type="STRING" id="86630.A0A367K220"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="14"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH96292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="552" mass="60672" checksum="30AA346E02FF7C54" modified="2018-11-07" version="1">MGFVLKGAALFRASTLLAAIGFLLFGYDQGVMSGVVANDLFLDTMGTPDSALVGAIVALYEIGCMFGALSTGRIGDWLGRRKTIRLGCLILCIGAILQTAAVNAGMMIVARIVTGIGNGMNTATIPVYQAELSPPKSRGSHVAFEASLLTIGVAIAYWLEYGLYFVKGEFAWRFPLAFQMVFAIILGLASFILPESPRWLQAHGYEEECKQVLARLWSDCDTTHPRCIAEWEEIRDGIELERREGISSYVELFKKGKMNNRYRVLLGMGGQLIQQFGGINVISYYLADVFKQAGMSTEKAMLMAGVDSFVYFAGAVTPIFTIERLGRRWLMYAGLIGQAITLLIVGGGEYIVQRDQALYGTLNGPASKAVIAFVMLYTFVFGAAWLGLAWLYPSEIFSTGLRAKGNSMSTAANWLGNFVVAMIAPVLFEYAKYWTFLMFGILNVIFLIPIYFFYPETMGKSLEEIEVLFATEDLQEDAKSIASHIGSVSLYEKTHGDAESGRGSRPHSRRFPSNFSGRQSVMSANKANDKPAVDSEAAHVKNDYDEKGPNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3G3</accession>
    <name>A0A367K3G3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000346">
        <property type="protein sequence ID" value="RCH96679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3G3"/>
    <dbReference type="STRING" id="86630.A0A367K3G3"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="323"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1226" mass="139658" checksum="DBC0C800D18184D1" modified="2018-11-07" version="1">MSLDPHLTRCAKQIYNHLGLTDRISQLQQPNVSYKEILLMKQLLSLSDHSLLDTIVTSFIKWNPPRQRKKTVNDFISQVSQEISGLLPEDIFEDIDDELFMNEPDQGKSNKRTSSEALDKVTPLTMVKKPKIDNTSPSTSRLNTPPPSPLDYFPAEATKSEEYNIIWSPTKSTKLFQGVSWIVIYEIARFMQACKIPWNEVPFDAFRSFIRIGMSEPRKLYEVMLRWNTETRLGQRLTGLAYSKMERCPDNVWSYIQTEKSSVTTQTTKEAMPFSPTSPPTSISINNENSFSQDSIKRKLLKNRMVRYSAVIQFKTTGTLPKINLRVPKITASNRLFRKFGQDRFLEMVLSESSQPSMVRMMKDFLLKPFLLMQRVFRFLFIKDSTLVFFATEGPDLEPISIQQVIDWHMPIIENWDMSMSKYASRMSLGYSSSIPTIQFDPSEIEYIDDIYSEIATVKDDAACMTDGCGIISCAAMKEIMGCQTTDELPCAIQGRIGGAKGIWILAPDMDFNSGKYIKIRKSQHKFKTGLPQPNCALDPHHYTFDLVKNSICIYPSNLNTQFIQVLAAGGVPTSVFVEILKEYIHRLATVVTENQNIKILRDWVTKTGSIMTRRWENEEQTEKCVWKDLSAEDDIENDMFHLDSDSADDDSKSDTSGSYTNKSHTNYLLSTKSYDSLNKYSGYPGNAFEAVVRLLDSGFDLTNAFVATRITTIFRQVMKSVNTKYRIEVPQSCTVTCVPDPTGLLKPDEVFLQLSTRRVDEKTGIRAGLVLGDVVITRNPCGLKSDVQKVKAVDCPALRMYTDIIIFPVTGDASLASKLGGGDYDGDLIFCCWDQRIVEPFQASPVIKELDRVTQAFQKDKSTLGQQIGAYPDPEKALQANFINVQMPDGTLGLYENWRTVLAEKSALDDPDVSYLAQMCARLVDAPKQGLHLKQSVYNRDRANFSKIPHPIWFMDKKNKQREGHKRAYKEANDCYTLLEQSPCVTTMDHLYKTLMTETAAFTKYSQCMFSEVDIPLKDHDLTGPWNRATELATGKNDSALQHDLELIRQAVNANMESYQKTMTEFHMLRQHIMDNIYDPNKYIENDAMDFTSPFASFFELEEFIAKEYHSTPDPSKFISPIFQFDVQVNGGYMLQNIKASYAYIICVSSRKYSKYCYVVAFDTLRRIKADALAKNNKENGLSETVSISIYPSLNMDRKWIRRIKESNVKSSNKSSSTDQITPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3R3</accession>
    <name>A0A367K3R3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF2421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_004935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000334">
        <property type="protein sequence ID" value="RCH96817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3R3"/>
    <dbReference type="STRING" id="86630.A0A367K3R3"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="261"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="745"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="878"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1126" mass="128866" checksum="03433F81D4BE2D9F" modified="2018-11-07" version="1">MDSTKRRPQNAVKEPIIGSPLSDPGIPSFSTSPQSMFIERTQSLDALQDFDFVQGSPSAQSEIDVILDDGTTQKRTVSLSTIPDIDESPDDRTPLLSSHKAKYQATNSPLISSSSSDSDSDEPFFPVQRKKPHRKHHAIIDDDDNSTRFAMFWGTLWTRLQLTPSQRLVLKCSFAYLLGSLFTFIPALNRLIGNNHTSSHLVATATVFFNPAKTLGGMLEAAAYGWGYVLFAVTLCLGSMFTTDYFIDRNHETIAHCISLFVWLAGATFTVSFLKAHWNKPPVATASSLCFIIIFIIVVREGSVNRGDFDTTRIEQITSAVATGTLITVACCILFWPSSAASKLKKDLDASLASYRVLLKLLTKTFLLDDDLPEFKANRTLQAAIQSHQASFTALQKSLKEAKLESFWNSEVRGKTQEYDQIVKSMQRLAQHMGGLRSSCGIQFEMMGSEATQQYKEMTRNKKQKSLFGGSRTQSSLMTSDVNWNVRAGYRRRKLQDEMRKQRSLVFDSDVVLNTPSTSKVEEKSTALFDFIQTIRPPLKSLAYTCKQTLYHLQSSFTSGAKNPTPSMSLLKTNLQKAISLFETSQKHAIQKLYQKRLDYLRKHRQGTDKEVETEAVGSILGEEVFLVYFFVFNMTEFAKELITLVENMQKLHETKRVGFFTWLFSWRKKTSNTPSVRTTPFIPNERNTFDTLHTPKPKTKWRKFFIQLWMTFSLFKLQKVRYATKATIAAVLLALPAFLEPTKEWFREYRMEWALITLMVVMTPTVGGTNLVAVYRIFSTILGCYSAMIFYMLFPANMYVLPIITWLFSIPNFWMILNNKHGKFGQFTLLAYNLVMLNKYNDRDTNEVEVWRLAMQRCFAILVGVVFGLIATAYVWPYEARVELRKGLSDLLLRLAWLYQKLISLYADVPIKQKQPLDPRASETQILTHEAQEKLATQSFMDLELSLQRSLIELNDLLSQTPNEPRLKGPFPINTYRTMLLSCQNIVDRFLSMRTVMLKDAWHNHVQHDFMAPVAHERREMIGNVLLYFYLLASALRLKTPMPPYFPPARKAWQQLLSHLKSAPIAQSKQLLEQDNVYVFYYAYVTLMEDVIRELDKLGDNMTKLFGSLVPIDQWELLFDEEHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4F1</accession>
    <name>A0A367K4F1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Atp2, beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ATP2_3</name>
        <name evidence="4" type="ORF">CU097_015019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000316">
        <property type="protein sequence ID" value="RCH97015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4F1"/>
    <dbReference type="STRING" id="86630.A0A367K4F1"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="7836" checksum="239A5C1979FC5215" modified="2018-11-07" version="1" fragment="single">MSVNRIVAASRAAQKANAALFKNVVKPMATRAYASQAASTGKIRSVIGAVVDVQFEQENLPAILNALEVQDHAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5W0</accession>
    <name>A0A367K5W0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000268">
        <property type="protein sequence ID" value="RCH97546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5W0"/>
    <dbReference type="STRING" id="86630.A0A367K5W0"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="56"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="316"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="381"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="442" mass="47122" checksum="78D5111953192E1C" modified="2018-11-07" version="1" fragment="single">PMPATKRHNNATPEKANTKRTRASPASDTEAAAKRAKKRVRTLLNKVAERPTDAGRVFVCGTNDFGQLGIEGDEKSRPVPLKTLADVDIVDVICGGLHSFAMTPEGNLYSWGCADEGVLGREGNNEVPAKVDVGDVSFVKVVSGDCINMAITAEGKLYTWGTYRGTEGIFGFSPTLLNQRTPLLYSALAKEIIVDIATGTNHSLALTAEGRIYAWGYGEQGQLGRRVSVRHPKDSLRCDLVGLKNVKLIGAGSYHSLAVTHDNKLYAWGLNNYRQCVDSDENIIPSPTLVSLPESVGTIVSVDAGEHFTLIVNEAGEVFTYGRGDANQLGLSEEVMAPLKVKSEESAFKFIIPVATKVSDLPPVSHVSAGTEFVLIACQNGQGYSWGFNSSNAIGNGSDDDEPVPKLLRGKNLGTNLILRVAAGGQHSVFLTKPAADAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6I3</accession>
    <name>A0A367K6I3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000249">
        <property type="protein sequence ID" value="RCH97780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6I3"/>
    <dbReference type="STRING" id="86630.A0A367K6I3"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="42386" checksum="B20EAB6BD7FC0F61" modified="2018-11-07" version="1">MTLKKRTLFFSIFTFISLFILLWNQFSTTKFRSVNNTSDNRVKACYVVLVRNSELDGIIPTMRQIEDTFNKKYNYPYVFLNNEPFTSEFMDKVRLSTNSDVLFGEIDQSMWGYPDYINQTYAAERRKEMEAQGVPYGSSESYRHMCRFQSGFFFRHPLLDQFDYYWRLEPYVDYYCQINYDVFRFMKENRKKYGFNMALKEHVETIPTLWDTVLNFTRSTYPHLLNRNDSLLRFITNDNGLTYNTCHAWSNFEIGDLSLWRSKEYLALFDHLDQSGGFFYERWGDAPVHTIAAVLLLKKHEIHFFNDIGYRHSDYTHCPVQQVYRTMCSCDPDINFDFNQNKSCLPFYLDAMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K906</accession>
    <name>A0A367K906_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000181">
        <property type="protein sequence ID" value="RCH98646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K906"/>
    <dbReference type="OrthoDB" id="10460754at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="20741" checksum="24F8D2072696C27E" modified="2018-11-07" version="1">MSTFVPQLKRENAFLGDPLKDNFCAICNHDEGTDSWCNVTCHCSRKIKYAHRDCLLSMSTCIRCNSSFVKIPERSSSKKPAPTMKQHYLKYTLILFALLYMMLLAYDLMNCTSIQTIYAHELPETDIVDRPDYIKFPKIHMKCLRRGVSYSIYYYLFNYYLFVFVCLFIIYYMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K971</accession>
    <name>A0A367K971_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase zeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">REV3_1</name>
        <name evidence="5" type="ORF">CU097_009111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000179">
        <property type="protein sequence ID" value="RCH98669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K971"/>
    <dbReference type="STRING" id="86630.A0A367K971"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="3">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="567" mass="65220" checksum="0EB9DAAC631182EC" modified="2018-11-07" version="1">MTISIRIVDIDHYLQRPCFLDRTYSPFCDDPLSRVPVIRIFGSTDAGQKACVHIHQIYPYFFVPYTIPQEYTLEDIQKSIFQFGTCLNQAFDQSIRPSPDKKNQHIAAIVLVKGVPFYGYHTGYQTFLKIYIIDPSEKQQMVDILQSQAIMGTHFQPFESHIPFELQFLMDYNLYGMDCIHLDTDTVGRHAEIGLRFRSPLVNTPRSEYNKSQASGSASMAEVHDKSVYTSETVPVMLQSDALARESHCELEIDATSMCILNRLDITERDIHANLSYEMKLQKHDLLNPDEVAKRKLVKSLETIWKDEAKRRRAKGNTEPLWSVSQTDDQRVPSSMPWTSEPSLRSILNKMIERSGSDTHTNKDPILLNGVMTAFQSVEALYPQEYYQLKKGITNQLGKSQHVATPQEKEMNQFNVISDPSRYKAWITQNYVDTNLIDSYLESKAKDDDEEQHFDLGHEETEQQILGDDTFDNDDYGLKESDIAKWIEESEKRKGSSRPVVSIEYEDDDDCIHQGGTMKPQKTNSLSEQVDMISQVGQKRKLRLEENDAQYTEDEPFQISNILPDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAJ8</accession>
    <name>A0A367KAJ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_010826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000136">
        <property type="protein sequence ID" value="RCH99244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAJ8"/>
    <dbReference type="STRING" id="86630.A0A367KAJ8"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000181">
        <property type="entry name" value="CALML5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="170" mass="19850" checksum="E9604B2F4CF4AFD7" modified="2018-11-07" version="1">MSNRINQQELKSLREAFNLYDTDHEGAIDVNKFENIVKSLGMIGIDDQRIRELIKENDSNHDGKIDFEEFVNIMNRLVSQSPLASPHETRTNEHYSKRMSRHELDELKMCFDKFDKNGDGQISEEELREVMKGLGEHLTEKEIKDMMNDADTNKDGHIDFEEFKQLMPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAU1</accession>
    <name>A0A367KAU1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_014161</name>
        <name evidence="10" type="ORF">CU097_014334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000379">
        <property type="protein sequence ID" value="RCH96322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000135">
        <property type="protein sequence ID" value="RCH99260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAU1"/>
    <dbReference type="STRING" id="86630.A0A367KAU1"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="120" mass="13541" checksum="47265A770566D35C" modified="2018-11-07" version="1">MASTSSVATQSLFRRFWDSPAGPKTVHFWAPAMKWALVFAGIGDLQRPAEKLSVTQNVSLMLTGLIWSRYSMVIIPKNYSLFAVNLFVFGTGAMQVGRILNYRMSDEYKQKQAMLEQKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBN9</accession>
    <name>A0A367KBN9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARO4</name>
        <name evidence="10" type="ORF">CU097_012404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000108">
        <property type="protein sequence ID" value="RCH99663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBN9"/>
    <dbReference type="STRING" id="86630.A0A367KBN9"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009396">
        <property type="entry name" value="PRK12756.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="45"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH99663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="360" mass="39578" checksum="0D0FE120B8DA5A6F" modified="2018-11-07" version="1">MTKSMTEDLRIQGYNALLTPVYVKEEFPMTQRSMETVAKARKEIQNIIAKKDDRVFVIVGPCSIHDTEAAKEYAELLLDAKKKYENELVIIMRAYFEKPRTTVGWKGLINDPDIDGSFNINKGLRIGRGLLTKLTDMGMPVSVELLDTISPQYMADLISWGAIGARTTESQLHRELASGVSFPVGFKNGTDGNLRIAIDGIGAAAAPHHFLGINNLGTICITHTTGNPSCHVILRGGNKGPNYESVYVKEAKEMLQKAGLPAAIMIDCSHGNSNKDHRNQPKVAQVIADQIAQGEDALVGVMIESHLREGRQNVPEEGPCALEYGVSITDGCINWQDTEAVLHNLAQAVQARRQCRKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBW5</accession>
    <name>A0A367KBW5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000108">
        <property type="protein sequence ID" value="RCH99668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBW5"/>
    <dbReference type="STRING" id="86630.A0A367KBW5"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="701"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="866" mass="99562" checksum="EFBCDF2F6B62BC04" modified="2018-11-07" version="1">MSLVEDSKNDKNTQYAHRKQCSVRIFVGPWDLSSHAEQMPEEINELSVALPEPEPNNISLLPPADVPSSPIITPSSEGTSFVTARSKNTALSPQQLSPFDEIDYNVLNTTIPPIDTIRDQTKTLVEDEDDAISVATVKPEKRLPTLPPTPGLALPTIALSSETAKSLPPIVKKKLKQKRRRTRNKTLKWKKAGTLFVPSTQPIQSERSTAMSAVLKRGLVICMRKVTDRIGSEPTRYRASKESKFDLLAENWTQVELVLTRSCITTYSFSTYFWPNHRLEHRIYFQGPNKPRDLELFLFSPLDYTFGLRFSSMAGKTPTTVSMMFKANTFLQCQEWYTQLYKVLPKGAKRSFPSYCEVYIPAMNLTLNLPLEETQGCYDITLADIKEAVMTVVEESGYDGKLFCLDDDEIGVCWATEERVEWVYWTASPANPDKRIDLAVCPQSIEQTHRLELRAIEHTPDHIILDQNDILNEPCPMEGFLVCASDFFGLTAKVTGKMYYFASFDQYLVYIPSTKATKPHTENIVNHESLGEHVWFISPYTSKAKSQSEMEEIKRRMRLLSEAKGLIDLTEVSYVKRHFIEEHDDIGYESHISHEPLLGGSRLLLRKNLPCILEFVMENGLQIQFQTYSQHTCDIWVNHLSQLIIYWKAQKEARRTIHLNDHFGDLVCSEKERSENHMRGREIRIADTRIWSYCLYERCHDVVKTGILYYKPHHRETFSQKIFILSANGWLLFFDVFNRNSTKKSGNHERKGAMDIAGSYFFSGVDSSKTKKGSNSNEENTVKVYSDGLTTDDDQLTRIFSIWKPTLRRYFSPKRQRLRVYRQDQQLTSKGETVTFLAESRQEKEEWICALNSVAEHLQSYVTKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBX8</accession>
    <name>A0A367KBX8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_004661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000103">
        <property type="protein sequence ID" value="RCH99734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBX8"/>
    <dbReference type="STRING" id="86630.A0A367KBX8"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="202"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="709" mass="81054" checksum="40FB750C2BB3A339" modified="2018-11-07" version="1">MSRLKSKYSDSFNDQFSSTEEEEDADVADQYDSGVIRCICDDPSDDGFTIQCEHCLDWQHASCVNVKRNRIPKHYLCDRCSRLIKKKRPTDIQNRRRNLQENKLLVKEKRKRLDSKSKKNNQEGSDDDEDLLQPAQKINRSYAYTSKCVIKQKAVLDIFKDVRHYWFQLNRQKTSISLDATIVKGLDSLVVMESNLLMPSIPKTSVKPLRKSMRSSYNNEKIPSLEKGVFADIHIPEDRYLMEVTGEVKLKSEYKSNNSNHFSLLATPLRHVFFYRSLDVYIDAREVGNDARFIRRSCRPNSEIRSIILPNDNDDNLIHMGIYTIEELDKGEEVTIGWNWQRGQLMYQKHQEFLKSKGTLELRKSEPEVKSALKKFLALYETEFGECACEDKDECFIECIKEELENDSDSEATEVKPLLKRRRPGRPRLGESTTRTTNANSSDEEQRPKSRKRVASSDTIGKPAFVKKPSSVGHSRSTSNEEAVKWDTTPITNMNSLNVNSNKEVIGGSLIRKLHCKKRWLQLYLLEQKSKENTKLDIMKVEQLNTAITMHVTSTETTSVLQSEQLLNNKNDEYLSDASSESTLPLNDTPSSPTSVQMDQPKIETPLENESLPIRSSKEANRLDAFNGANGPCIEARTDTTVEQSEEQKHDDINQTVKKLDEPLNSSVPLKECAGPSEAQASTAENKPVARVKLSIQEYLSMRRNLSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC01</accession>
    <name>A0A367KC01_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000102">
        <property type="protein sequence ID" value="RCH99762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC01"/>
    <dbReference type="STRING" id="86630.A0A367KC01"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="7977" checksum="9A40B9F1DCEA5D41" modified="2018-11-07" version="1">MSCINYAALKKQVNIQAIGFDKDNCLTAPYASNIHPPFENAWEECKKTFGKDKVMIVSNSAGTKDDVGHKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDK3</accession>
    <name>A0A367KDK3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000073">
        <property type="protein sequence ID" value="RCI00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDK3"/>
    <dbReference type="STRING" id="86630.A0A367KDK3"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="764" mass="86241" checksum="7D48E37818E55C76" modified="2018-11-07" version="1">MTNSAYTAQLLENIINLYLTKENALVKNLSFILESVVNHDLLNEVSASNEEMASLHKKWVTRLNSLLQSKNAAVRLCAITLIRTTCERSHTLLVANAKSWSAQLLGFIGKTEADTIHKESIETLNYIFGYTHDKPELHREVATPNMPRYNQLLLQLAQKEALLPTVLSALTANNAHFPSNSKHIAEQTLQLCLSCLDGSRDLDQVVVQRASKCLASLYRTGNKATMADQWRDMLLRLIGSVHQCLNRLFDTVDEESFEFDPSSSYPFRPVERDYVEAFPVLLKRIQLLQESISTFLTTATHVPVRVPVVQLVDLLCRIYNVFDGSLMRDYKDRSEFFSVMMCLPTLHFNTTKVFSSLLYCTGQEMLRYSKLFSKILHRLLTEYKHKRTLRLSVYKLIRLCLEKCGYTFAENFTKPLIAAILEDLQIVEHKPTSLVMPSQQKGSHKKRKTEVTNSDSITSRLVSLASGDVQAAALQTLATFLDVFGFALENAQRASIDSTILMRLLQTVQPSNMSNEEVNLVKAELYSCLLASVTRPMEAQASILPHAVRLFTVGMNDSTHELQMICKRGLTICDLITHARLPPIQRALPKESPVVQLDAPVVEKKLEKKTVEVVREEDNSPQSKDSEATDIQVQRASFKEPPVVHWNTPAVEKKVENIVAEEVKEEAQSKSEESMDLKEEAPVFNIPALPKESPIVHLNTVVMEKEVEQTTVEMEIKTVEEMDAQNEDSQSKNNEAIDIEEEMPAFDIPDIDMAGPDSDVEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDU3</accession>
    <name>A0A367KDU3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CWC21_2</name>
        <name evidence="9" type="ORF">CU097_015639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000065">
        <property type="protein sequence ID" value="RCI00359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDU3"/>
    <dbReference type="STRING" id="86630.A0A367KDU3"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="16103" checksum="95DA83A43A6A1AA6" modified="2018-11-07" version="1">MYNGIGLTTPRGSGTNGYVTRNLSFVKPPPQRKDELKEESGPKLKKANAAILEHNRKRQVEVKCMELRIKLEDEGVDDEEIETRVEELREKLLQESQPIDAKKLKEHDVHELAAAKEKELEKMRRALRIKEDRADGAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDW4</accession>
    <name>A0A367KDW4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000061">
        <property type="protein sequence ID" value="RCI00423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDW4"/>
    <dbReference type="OrthoDB" id="2218844at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13845" checksum="4A377F71B716EB0A" modified="2018-11-07" version="1">MSTFKKIQLETTPRVYSQHYITQDICYDLYPSLSRQLSNGYHIRTDPTTNTKNIDFTLMNIPFARRIAFTYDPFWDLPTERQDDQWDLYPAILRNVENFGTYQMRQRLHRMLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE03</accession>
    <name>A0A367KE03_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YncI copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000082">
        <property type="protein sequence ID" value="RCI00072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE03"/>
    <dbReference type="STRING" id="86630.A0A367KE03"/>
    <dbReference type="OrthoDB" id="4234at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="entry name" value="Uncharacterised protein YcnI-like PF07987, DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-copper_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016647454" description="YncI copper-binding domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="YncI copper-binding" evidence="3">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="216" mass="22668" checksum="BBB8E6C8F846B772" modified="2018-11-07" version="1">MKHFCTIALLALVSNLVDAHVSLSPKFVEPGQNLTTAFHVPHGCNGSATISVTATVPENITTISPQAVSNWTLSLQYRDASNSSLSNITWYGGYLKATDALDFPLVISVPKVDLSSQSNVTYYFPVVQTCEVGSTNWTSIPQPGVDSHSLNNPAPALVVVKNATQAAADATSVSHDHGSNSTSSSGHENHTSGSNSLYLGLLPVIATTISALSVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEC2</accession>
    <name>A0A367KEC2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000059">
        <property type="protein sequence ID" value="RCI00460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEC2"/>
    <dbReference type="STRING" id="86630.A0A367KEC2"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="68837" checksum="E2DCCC2D8FBD4311" modified="2018-11-07" version="1">MDSDDQLSDTSLHESSPPRTLRVINPDFDEETIQPYQPGLVNDLPSTPELQPVCRRMSKTLVEQHSPQPFELLPPLKTLPPLMDDMMISSEESSPRQEQHKEEEPPHPPELPQHDPGLTSSYLQPRNNKAIAEYHERPPSIASFTPSQTPSNAFSYQSKYAKASYSLTNHPDAIKLYRSMALKTKDPIVQLTYAKYLLEIAGLYDKPSTSSQPKPSNVFLRPVSRMSYRTSMDSRRSSIDNPNTQQPAFVEEDVDDAQIQKQKMLQEEGVRWIKKLANQRVGEAAYLLASWLDRGLYGFKKSPAKALKYYEVAAKERVPEAMFAVAQYYEKEQDYMTSFQLYEDAAGLGLVEALYRIAMIHLNGEFGSRQNVMAAIQLLIKACEKSTGTACPEAPYTLGLLLLNDYPSVNIPNEIIQSYGGSFGAMSYLDHAAEIGLSSAQYKLGTLFEQGRYNQRIDLTKAFHYYEMAAQQNHSLAMIALSRLYNQGVQVPQEQVEEQRYLFEHDESQWIKTHARDEDAAFRWCRLAAVEHHLPEAYYLLGWYYEVGIGVPRDYKKAHHYYSKASKHDHKEAKDRLKMMEHVVKFKKLENKQRGSAQCHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEF2</accession>
    <name>A0A367KEF2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RHO1 GDP-GTP exchange protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ROM2_14</name>
        <name evidence="8" type="ORF">CU097_015359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000051">
        <property type="protein sequence ID" value="RCI00595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEF2"/>
    <dbReference type="STRING" id="86630.A0A367KEF2"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="185"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="369"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="594"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="7">
        <location>
            <begin position="755"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1112" mass="127758" checksum="E760AEF38E9EA26C" modified="2018-11-07" version="1">MIEYEQINMTPAEAIRNQYYLSQQGQLSSNQNVPDKIQLPRQEPQMTLYEPQSDQEPKIVLEHNNNSNNNNSNASEFQKSSDHIIRRNSSKFLLKLSKSTAPMRAKLSTLSPSKSQLDQLWASSSSTLTRPIRKSAESVHHLSLYRRNRSYSKNERSQSFSFEQKVPNTISCAYPALLSNVAEAFKESIIVGTRVKDNIIYHDVFDGKDAVDKLCSILRTPDRDLAKLIGRALNHQKYFHDVNYEHKLRDSDKELYQFKELNGIPTPTKRKITNRKATKDERRNARLPNGVFTLWTRCYSPTCSIDSVCYSTSCPTNNRKGSSPIRDSKIKVERSISQNSLNVEKREDRLWQYTVPKSVLNSLSLKERNRQENIFELIYTEQDFVNDLAYVEESWIFALKDSDCIQKDRRDQFIKDLFWNISQVRKTNQLLVQELSLYQSTHQVVDQIGHILLKHVNSFEPFVTYGAHQFISRHIFETEKSSNPAFAKFVENVEKLPESRKLELNGYLAKPTTRLGRYNLLLKEILKRTPEDNPDTAALPKVMEIISNFLSRVNEEVGKTENRFCLQLLHEKLSDATKNYPYKDELNLLAEERRIILKGSLKRKVLNHASEAADIHIYILDHCLLIMKSKYFDHAEKYKLYKKPIPLALLTISLPEPNKRSSSIIPYTIGASTDAIFLLPSYSTSSTGSNSHKTRFPLNFTHLGRHGSGTLTLYASTLASQRKWLDTIENHKRMIMEQTKAFNIENISHQFFNTFFKVNCAAAYNRFLFIGCDHGIYVKYLDNNEDDEHEGIKRVLHLNKVSQIDILNDLKIMLILADKTLYFCCLDTLIDGEKLLTTMRVEQQKEASTTSNDAECSGNSQHLRKISSSVSFFKVGKVFDKTTSADKPVERTLICYVKYNAMTSTIRVLEPRSNTQDIKKKKISKGTGVFMRTSAADSLCLFKDLYIPGEATSIQFFKSVVCVGSAKGFQMVDIASAGVQSVLDPNDQSHQFIKQRETLRPIAMFKHPNGSILLCYNEIAFCIDRKGRRIKSDWMIEWEGHPHSFSFHHPFILAFDSSFIEIRHVDTGKLVQVIPGVSIRCLQPNNTTETTIYCVREDEHRTGTEIIFGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG19</accession>
    <name>A0A367KG19_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000022">
        <property type="protein sequence ID" value="RCI01173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG19"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="33536" checksum="9904182F7FCA3123" modified="2018-11-07" version="1">MDDASTDLSWWNVAEASVFVFIAALISLIFGIKLEFSLILSGIRCVIQLSLMGLILDDVLRTKHMSVIIIMSTVLVLLASYETVFNRTKKSFKRMFPIMFIILLTSNLFITYVGTAVVLQAEPFWDPPTFIPVIGMLLGNSMTSVAMATERCLDDFRIHAPALETRLAYGASRFEASLPLAVEAIRVALIPVITQLSVMGMINIPGMMTGQIMAGAPMMQAVIYQQSIMFMVAASSTLGVIMAVTACMSILIDKDQTMRYDRIYENKSRLFNLKHWKEKLTLLSLYCQKMSPRKTSGDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG83</accession>
    <name>A0A367KG83_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000023">
        <property type="protein sequence ID" value="RCI01151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG83"/>
    <dbReference type="OrthoDB" id="10272502at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="568" mass="66011" checksum="382FA0A09FF1DBE1" modified="2018-11-07" version="1">MANFQRLPIDILHLIFNYLKEKEDIKNCRLVCLQWCMALTYRLFQDISIKDEYHLKALLNLTTSSNSNRLIQLGRYAKTMTIYSSRDYKQMPVITRHDFEQLVKSCPHVHKLLLDAFTFGKYISAYLLDISDDTKWKVQSFGLKHITMDIYYKYKDSITEFYAPYRMKSIRDLAYFPLLQQVHLHAFPVTTMEDFMFIFDACRNIRHISMTVDINTPSHVTCSQDLYLSLTRAEFVCRGRQIPKDLIDCITHRFTQISDISFYLDNESPRPIDESDYDRLVKHVVKHLKQESRLSLYKPIFNAEHLEQAAIAINNCLKSISKQSSITSSVHFTIIQSMSWDNETVKLLDTFKRHDDDMIHRHLELHCPGRYPLQELIYYLRNAKPYIQELTMMNEDSSSVTSADHIDATIYQCHQLQKLTLFRYGLPSLQGCVNRTVQSICIASCNIHTGFFDDLATAFPRLKNIDLRCNTIVCDSDGAGSNIIDLGSLILDKLTLVLSIQNDMSTSDTQEYLVSLKTHRKTSYFVIDNKRSPRKLSTDEATEKDKSIDYLINCHDVQQFALDVAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGF8</accession>
    <name>A0A367KGF8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PAAF1/RPN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000020">
        <property type="protein sequence ID" value="RCI01221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGF8"/>
    <dbReference type="STRING" id="86630.A0A367KGF8"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF19">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT RPN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="403" mass="43264" checksum="1A5FD98CEA61B0CF" modified="2018-11-07" version="1">MSTVELPLISVQTDWDQVVREVVSDKASNSFFWIACYLTGKPSVQGQVEVIKKDNGEYELEGKNGFTVSSLGSRSFKVECSELGAKDIIVYGPKDEIILAEKARPTCVDVSPNGRLFATASGSEVFLGNLSEAKVQTILKGHLSDVTAVQFFPSNLVLLTGGADFQLKIWSVIDGSNPVTLRGHTSASSRDGTIKLWNCGTASVIATLGKYQCPVNKIVLAKLPSSYQPAAKESLDPVEVGTEDKMVIAALGNGSIRGFHLGTKSEIFASPTGPSALTALVYDETLDIVFAGSENGQITAYSLEKGLEEPVAQWQRNKFPVTSLAIKLSKNGERVLCVASADGALYETSALSSLKTDSSVRVEIEYTGNELESVNEVKVVPGEEKEGYQSIVCSVRDGKLKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILY2</accession>
    <name>A0A367ILY2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005015">
        <property type="protein sequence ID" value="RCH78636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILY2"/>
    <dbReference type="OrthoDB" id="2264060at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="12276" checksum="038F8BE94FF71553" modified="2018-11-07" version="1" fragment="single">TFDVCYENDSKRPVLVHLSFIRNDPTTFKRYLSEYSDVDLEDKAGAKAELVTERQVIMFLNEVYKTTNPKNEALYSMQQIETKEVYESVISKAEFMSKKSEIGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IM94</accession>
    <name>A0A367IM94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004918">
        <property type="protein sequence ID" value="RCH78785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IM94"/>
    <dbReference type="OrthoDB" id="2268044at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="109" mass="12776" checksum="11773702D2903F37" modified="2018-11-07" version="1">MNLLQSLPGAWIEEEEVEELKKSQDDIELLKQTIETLKKEKEKLEETNHIVKKSIQIVAEKRLLAEQAKSDRKLLKNEDYIIVAKDERIPTQEELRAAGIEGWEWISTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMK1</accession>
    <name>A0A367IMK1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004829">
        <property type="protein sequence ID" value="RCH78910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMK1"/>
    <dbReference type="STRING" id="86630.A0A367IMK1"/>
    <dbReference type="OrthoDB" id="2276648at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH78910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="311" mass="35776" checksum="292346D4132CF2AB" modified="2018-11-07" version="1" fragment="single">MSEITKGIRSESHLVRFLHEITDFSGSTRYRLNGTGSMDNPLNWLRQLERLKNISGVQDRELLIIARDHLIGKAAAWFDVNSDTFKTWDDFTDSFKRKYCSGLEDVWWNEIRNLRQGADEDIEDVDIKLRELFALVGVTDERLKIRLFLDAIHPSIAWEVERSQDVNRYKDLDSVVTVASRVESISRKYHKKGVSTSRWTAKSESTKKVEEEFNDLVDETRSVKTTSTMEELLKEFKDLKISIVKTVNNINGTSGNRGSRNFVCFYCKKEGHKKFECPEFLKVKQGDSKPPSTELRANKDNSGKEVGPQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMS4</accession>
    <name>A0A367IMS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004785">
        <property type="protein sequence ID" value="RCH78975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMS4"/>
    <dbReference type="STRING" id="86630.A0A367IMS4"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11051" checksum="7DE54C9B5CBD328C" modified="2018-11-07" version="1" fragment="single">MSDIVVPGFKSSELIAELNKSFENYSPEEKQKLIKQVNGVFQFVIKNNEGKEEVFVVDVKKEGKVSRGKGVKPDAILTLKDQDFVDLATGKLNGQKAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMU7</accession>
    <name>A0A367IMU7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPS1_2</name>
        <name evidence="10" type="ORF">CU097_000426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004768">
        <property type="protein sequence ID" value="RCH78998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMU7"/>
    <dbReference type="STRING" id="86630.A0A367IMU7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000022">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH78998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="195" mass="21644" checksum="D584F983932035F8" modified="2018-11-07" version="1" fragment="single">LDSPYVTKYYGSYLKGTGLWIIMEYCAGGSCSDLMKMGTIREEYIAIILKELLKGLDYLHNEGKLHRDIKAANILLSANGEVKLADFGVSGQITATLTKKNTFVGTPFWMAPEVIKQSGYDFKADIWSLGITAIELANGEPPYAKMHPMKVLFHIPKNDPPQLGPPHSKAFRDFVSLCLQTSPANRPTAKELLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMZ0</accession>
    <name>A0A367IMZ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004742">
        <property type="protein sequence ID" value="RCH79035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMZ0"/>
    <dbReference type="STRING" id="86630.A0A367IMZ0"/>
    <dbReference type="OrthoDB" id="59699at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22400" checksum="0A235F7D894EEF62" modified="2018-11-07" version="1" fragment="single">MEAYQTKPRRIVVCLDGTWETPYERTNVYKFAQALANGDVVDYKGQAWEQVHTYYSGLGTSRYKILGGLFGYGISGQIKSAYKYICEHYRDERDEIWLIGFSRGAYAVRSLSGMIYNVGLLPQNKVSKVEQAYQLYRLRGENGRPNGADAIKFRQKYQCKMPSIHFLGCFDTVGALGVPKLPWFLGGSVCKSQLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN83</accession>
    <name>A0A367IN83_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RHO3_1</name>
        <name evidence="10" type="ORF">CU097_002311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004681">
        <property type="protein sequence ID" value="RCH79142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN83"/>
    <dbReference type="STRING" id="86630.A0A367IN83"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH79142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="182" mass="20739" checksum="75E5ECEEEAE63C0A" modified="2018-11-07" version="1">MSFCCGKSQEEKGTVSRKLVVCGDGACGKTSLLSVFTRGYFPQSYEPTVFENYVKEVIVNDQTVELSLWDTAGQEEFDRIRLLSYADTHVYLLCFSVENRDSFENIREKWLEEVTDHSPYAKIALVALKCDLRDEWPNCITYEEGLEMAKNINAVRYLECSAKRNRGVKECFEQAAKIALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP96</accession>
    <name>A0A367IP96_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004486">
        <property type="protein sequence ID" value="RCH79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP96"/>
    <dbReference type="STRING" id="86630.A0A367IP96"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="16046" checksum="8C34F29DB799484C" modified="2018-11-07" version="1">MYQEDESSSVASSYEEEDPMEIFVDRCSICFDAQHNLCIESCRDQFCLDCFEKYIVQVVETSWGLSVTIIKCPVCSEIIPKHEWSRYVPKRVVDLYEKYNKPYRSYSRACPHCDVEITPCVHQDTHQPIYQQTRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS05</accession>
    <name>A0A367IS05_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine threonine kinase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">STK10</name>
        <name evidence="10" type="ORF">CU097_004239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003906">
        <property type="protein sequence ID" value="RCH80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS05"/>
    <dbReference type="STRING" id="86630.A0A367IS05"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="23363" checksum="817A902732B7B39C" modified="2018-11-07" version="1">MDLQRCSVFAILCQRGIPEQYTVHITCETLKGLCYLHSKQFIHRDIKCENLLIGWNGEVKLADFGLATKTTRRNRERLGTSKWMAPEVIREQYYDEKIDMWSLGITIIEMMDRVPPHYLIRDETELFKAILSEPSPTFTYSLPTMYMRGLVAWLLDEQPSTRPHAVDVLQEIEAHVQSKLLQCSTSQELARFVNHVLSSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISF9</accession>
    <name>A0A367ISF9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003823">
        <property type="protein sequence ID" value="RCH80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISF9"/>
    <dbReference type="OrthoDB" id="2261494at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="51" mass="6033" checksum="3C9420D4DEC51AA9" modified="2018-11-07" version="1" fragment="single">MLPASEGTIYELWLKDLLEIKPDIDDKLEAIPNVLQFCWKKKKLLKETSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT88</accession>
    <name>A0A367IT88_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003672">
        <property type="protein sequence ID" value="RCH80915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT88"/>
    <dbReference type="STRING" id="86630.A0A367IT88"/>
    <dbReference type="OrthoDB" id="2379842at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21552" checksum="982D4632A6FD1F57" modified="2018-11-07" version="1">MKVIIKPISFLNIQDSQKKKMELVLNPTGDGNCGFRCIAHAIYGDENLRMRVKQEIPSIVNSPQPNARSVGYIREEDVGHMLSNYDLTPPSNCWFDSIDCPQIVAEIYNRAVAVYSETAGNTLYLPFRNETPNEFRPIMLYLGQSNVQHWHLIAFEKKLGKLVWPSLSPLYEPVHISLGLNDNSILYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITI9</accession>
    <name>A0A367ITI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_000246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003627">
        <property type="protein sequence ID" value="RCH81010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITI9"/>
    <dbReference type="STRING" id="86630.A0A367ITI9"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="433"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH81010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="63573" checksum="F52C084263AFEA41" modified="2018-11-07" version="1" fragment="single">APSFTFGSTTQKVTSSAEADKDNEPSEGTKATEDNGEQENEPSTEETESKPEEDKPATPAFTFGSTAPSTAPKAPSFTFANVSATSSISTSAPDSTTTTTSSIAPVFSFDSSAKTAYSPKLSFVLLPQASLLPFGTSAPTSAPTTSTPTFSFGTPATSITSASSKSTPAFSFTKPVTSTTATTTSTPAFSFGTSTTAPATDTIVAATGAPATSTASAFSFGATKTASSTTATTTSTPTFSFGTSTTAPVTTTTSAPTTNTPAFSFGTSATATTTSTPSKSTSTPVFSFGATAQKATESSASDKDKPVGQFSFGTPPTKISKDTSKPVTPASTMTTPALPTTSSSTAFSSFVSTTPSKGKEPEKPGSVAIAFSTTDESSKKSEPTTLSLQPIAKDTSRDTAYVPTTLKSEINDPSQVTYTTRFWELPDNARNELAELQQFINEQAEKRDRIQSEINSGFASTLKQVQEKTEDLNVDADILTKQLDIQSGTLYDLIDKNAEQRRNVMAAGSVLRQESRNWRTLGASENWHFFTNTVNSLESRTRHYAQAVQSIEEAVSSLDKETKFSPELLADVMAGQKRMYLSLAGRVAEIHEEVERIVKRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUT6</accession>
    <name>A0A367IUT6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003436">
        <property type="protein sequence ID" value="RCH81437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUT6"/>
    <dbReference type="OrthoDB" id="2286670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="9526" checksum="9FD571BD983506A9" modified="2018-11-07" version="1">MGLSSHLSKFFKKTFSTTKDEEVTTNNNTPAASIYSADGSRPASIVINTGFIRDPTRCGNTPDVLGHYYDPMGGKFSLLHGVDPTNTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVE7</accession>
    <name>A0A367IVE7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003340">
        <property type="protein sequence ID" value="RCH81658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVE7"/>
    <dbReference type="STRING" id="86630.A0A367IVE7"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="235" mass="27029" checksum="F2F21596D9DD3A16" modified="2018-11-07" version="1" fragment="single">MAENKKKEKKDKKKKKEKGAAVEEERFKPVINPDYNPTDSNNNEDAEKWTIASKRSDIIQPNSPKSPTPAELQGFTAYKYVPSPGYAHLDPSKHKNAHSAFDQLQKVIAAQEQQQKQQGSPQKSTQKKQPKQPQPQQPLPSQQHKVQPQQPRPQQQHRVQQQQPPRMPQTGHAFQQRPPPMPIHQSPQLYQGPPHQQRAPYTQQQQQQQQWPRQPGQPSQPFRLDDGSSVQHYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVG1</accession>
    <name>A0A367IVG1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear control of ATPase protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCA2</name>
        <name evidence="6" type="ORF">CU097_004310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003318">
        <property type="protein sequence ID" value="RCH81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVG1"/>
    <dbReference type="STRING" id="86630.A0A367IVG1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="484" mass="55215" checksum="45386356BB40DD5E" modified="2018-11-07" version="1">MDTFISEHIKQLDASLDTTFTKHVQEYSSVQQISDNLLKSTQALDLSSLPSLEHIRDNLVTLTQLRENERTDTDLEWLFIAKCTLAVYGYVFSDVLNLTLPVSESIDYWNGIEGSTWQETYYALQTIPFRLYSLAKDAARHISNSVDMQSLFTSSDYLLTQLFPIHSRKSLDARKFFGSLQRRPFLLQMIHEEIRFKRKALEKFRSEQAANLGMLLTASPQFNNSAEGKTFGQSVGSQVNQSVQMLSFLLNPDTTINQASMLTSLADTSKEAAIDNVVDALTRIIHQWPNARKRYVAAVQESYGKPSRLTRYWIPAVLSYFLGQIALRYALNRKEDIVRCVGELGNTAHDFLINWIWEPVKKVWETIRLKDQQLRLLSKQGLQSDLESLERMVIGFAKDNLHWTEGDLAKLAEDIREGDISVVLREYEKEIKSPLKNAVLGDLLQTILIQVQKTKVDVDLAMSALDKLLRSNELNFAFLGSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXW2</accession>
    <name>A0A367IXW2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002983">
        <property type="protein sequence ID" value="RCH82530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXW2"/>
    <dbReference type="STRING" id="86630.A0A367IXW2"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="5">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH82530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="455" mass="53130" checksum="3B58DC371F431969" modified="2018-11-07" version="1" fragment="single">TAPRKLHSHDVAAPVTDTTYHKEVSGYGFPDFEGDSNDFWKVEIEDGDKLEARKVSFRLYHPNQSCRLYSNMERLPDWGFQQLEVSCIVEGTKPKTLWKVDQHENDLLPDSVPRVLEPRPSFYEKFIYLQKKMWTVNKDLTDTHPYESRPSAWPVLLSGIAFWSKDTRQIILLGNPLIYWVSTVSVFNFLILAAFFQLRDKRGYHDHFGGQRQFYENSAGFFVAAWAIHYLPFYFMKRQLFLHHYMPSLYFAVLTMGVGIDLVTRKVAVKAKPLVLVVITAAIIYTYLIYAPITYGETWSLDECQRAESLGKWQLDCGRYAVKMHPVSVKQEEVEVEEEEWVVTPTEPLFESQYEEMEYEEMEYEEMEYEDMEYEEDDPTATLDDDEEDLDDEPTELPEAYEPEPQFVNGTELVAGDDDDEDEWPRTVYGTDPDAEEEDAPVEIKDIPLTRHIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY92</accession>
    <name>A0A367IY92_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_003920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002939">
        <property type="protein sequence ID" value="RCH82657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY92"/>
    <dbReference type="STRING" id="86630.A0A367IY92"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="647" mass="72430" checksum="3EFE2567F93185E7" modified="2018-11-07" version="1">MTDNNKPTVVDDFFSALFANDNNKLNTKEPVSEEPKEQEPDRPQDPYRRLQTQQEQQQHEAMLQGQEMKQTKKYNYAKKHETELDEFDEYSLLSSKRKLDDATSHSGRQAPSKKRVAAPDANSILSKKNVDWSDVSPESRMLIRQLPARVDKEDVMAYFSAYGEVLEVVFKNTFGFVQFDSPLACANAVQCENGKKFKGITLELEICRTKPYFAREDDRHRQKLARPGPKIHRRNDDHSYNRRLENRHQAPPPQQQQKYADNTEYDPRHPEISLNTQIPVVKIIAWNNVSQQFISNVEDEFRKKSISVATVILQFPNTRESLVKQMAMEGVKAVVTINRDLESQRKVSLQVFTPNTTGRGIRFDEYDSILGEQAAEIVLRSLSPSESTYHSSALSSVPVQNNYPAATMSSTNSRQSIATSTSSPASAPIQSIDSNTLAAVYSLLQPKPVPVRQYQQPNQAHTTTTTTSTTNTTSAVAAITTPPTQYQMPQQQQQQQQQPTVSQLLATLLNGLNQNNSSSSSLSSATANLSISPKANHMTMTAPFNMHPPQLQAQQQQQQQQPNIAQLLSTALNGNPMVAQLLSSQPSLANNSNMMNDNQIRNILANYQMMQPSSNQPRSSSTNAPSPTAPPTIPNSNSFNLTTMARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ69</accession>
    <name>A0A367IZ69_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-3' exoribonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RAT1_1</name>
        <name evidence="17" type="ORF">CU097_003454</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002903">
        <property type="protein sequence ID" value="RCH82761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ69"/>
    <dbReference type="STRING" id="86630.A0A367IZ69"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="16">
        <location>
            <begin position="334"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="495"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH82761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="859" mass="98342" checksum="841550D0621B32AF" modified="2018-11-07" version="1" fragment="single">MGVPAFFRWLSDKFPKVVTPVVEERPKIVNGTVIPVDTTKPNPNNEEFDNLYLDMNGIIHPCCHPENKPAPATEDEMMVEIFKYLDRIVDIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAQLAQIEQEANERVAQELAAIGQEHQLKKKEEHFDSNCITPGTPFMAHLATCLRYHIASKQNTDPLWKNLKVILSDATVPGEGEHKVMEFIRVERSRPEHNPNTSHVMYGLDADLIMLALGTHEPHFKIIREDVFADNKKKTVCGNCQRRGHKTEECRSAVVAPSVTAANGAEAPKSEEVVDNNLKPYVFLHVNILREYLEHALKFNIPGIPWDLERAIDDWVFMCFFVGNDFLPHLPSLEIREGAISKLSLLWKQCMPFMGGYMTKDGDVDLKRVQVLVSELGNMEDAIFKERRETEERRAEGAKRRKLENDRRAMEARTLENNNFALMTAAPVNNPSAGMSNRDVAANRAQLRQANLSAAAALKAQLTGAAEDVAQAPPMEQKGVKRKADEIEEEEEGDSVISEDDDEPETYDPVDPVEAGKAILKKFADEKKEKEIAAREREPDDAVRLWESGWKERYYNKKFHLTLDEKDEIRHIVKSYVEGLVWVFKYYYRGCVSWSWYYPYYYAPMASDFVNIDSFDIKFEKSAPLKPFEQLMGVLPAASRAHIPKPFHHLMTDEDSPIIDYYPTRFEVDMDGKKWEWQGVVKLPFINTNRLLAAMNTVYDQLNEEEVQRNSVGVSVLYISESHKAYNFLSTVYTKRSNEKAKLDARLTDGLTGEIDKDPECIPRSTFYSPLPNHDLPDITNDKSISVVYELPPIPEDYNFSTNLLKGVKIKNCLDYEDIQLATFEKTDSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ83</accession>
    <name>A0A367IZ83_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002825">
        <property type="protein sequence ID" value="RCH82970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ83"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9260" checksum="EC0B3DE47C7EEC15" modified="2018-11-07" version="1">MRLTVEVYNFTVTSIPVITFCQKGSVKAKMNVGNQSYSIAIISYHPGLIEYMIRNFQINFVHSVKGDVSTGFGITPMVELKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZI2</accession>
    <name>A0A367IZI2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002775">
        <property type="protein sequence ID" value="RCH83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZI2"/>
    <dbReference type="OrthoDB" id="2285471at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19335" checksum="7F74190804DECCF7" modified="2018-11-07" version="1" fragment="single">SCLKYSTLSIIPSVWLILIKLLSHPLLKIKHSCIYAQKSECRKCLKETEEACVAYWIVSKSNVLTDAPKERQQKVYAKLRVCHRDVKRFSSSQTKSGKSDMTSTERLLRRAADTACTIRHSNADLISMRNYTENEEANGLLLAYAEAFSKLQSLKDKYSSHFRTLNTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J102</accession>
    <name>A0A367J102_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002674">
        <property type="protein sequence ID" value="RCH83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J102"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="231" mass="26792" checksum="A355B268338A8BC3" modified="2018-11-07" version="1">MHDHRVREDREGMVIQLDNKETPSDHRYSLKAMVRVDHPDVDRDNERRILKALLDEQLWELIEKVDLAAKYAHEYFQLVCDYINNGPAIEKSEVMFNYKIIWPIIALAAKARAAARFHPGEILLNTSDKDYKTDGLIEMDEIEVCLLETSGHYGLKYLDRFGHDDEDTLREPKVFFIHVRGKTYFDSSITLILKNLDNPRQNNASVDSRDPSPRSTSSRAFGQLRNPFDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2L8</accession>
    <name>A0A367J2L8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002440">
        <property type="protein sequence ID" value="RCH84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2L8"/>
    <dbReference type="STRING" id="86630.A0A367J2L8"/>
    <dbReference type="OrthoDB" id="2281104at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="171" mass="19293" checksum="BE8BEB4C718D23AF" modified="2018-11-07" version="1" fragment="single">TFHKTICVSTIRSNIDRINLKELKRLEDEPICVPAFNIYRGGNRKSASHALKETRLLKELQLKPNIPVMLIQNLQAGRGWVNGTLAKVTEIDYENILLIKQGQEGAEDSLWIQRTSSSIAGTSYVRTQFPIVPAFATTIHKAQSITIDFVAIHLDHMHFMFNCTLQCLGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2S6</accession>
    <name>A0A367J2S6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002480">
        <property type="protein sequence ID" value="RCH84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2S6"/>
    <dbReference type="STRING" id="86630.A0A367J2S6"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF28">
        <property type="entry name" value="YEMANUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubinuclein middle" evidence="2">
        <location>
            <begin position="325"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="612" mass="68250" checksum="91FD1F7206F95826" modified="2018-11-07" version="1">MLKSGSARIHVDVKAQQFPVIFSYHQLKKRGQKSQTTHNGLPIPELTNEDDFFKELLKKAEKYNLEDEADAEEEKEEGKDKDKVTNEDDDDEGSDDGSTGDNQRGNEYDYEDPFIDDSEMLLDDDYDYDIPEIDGFFVYSGPLDSNENSEDKKAGAASNSQSSHSNKRRSAAKTKNTTTTATKTSKPRKKEDTTNTPSQKTKSKKTVVPTSTSTVNQETTSKAPVSSTSSNNNTNVKKISKPPAPSTPGPSLSSPASVPAANTVPAASMPGTSSAIPSESNKKQHSLPSEPSKKKKTETGDSNRPIVIQDEDKKKKGTEVPPLLPLDSELEAIMNRIREGASKESFENKAKFPESLKPAVLEAGLISFRRNPILDVNLIHHLMTCLPYNRFTLRKFITTKSGQMRVDELQQEIDELAIKLKQTIDKMMPAQQQMHEARVAALKQAKAVKVATAAANNNGFIDVDALEPDEELEPKFKYTDEVRQILYDIMKADEQSTLISNLITQYRNGANNTKDAEKLVAEGKARKLMYQRLLSCWPDGWMNTYEISRQYNLYKNKIAGSQNGEGKKRRKPSEDHTHRKKAREDEPKEEHHTPKGAVGNSPMKVESLVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J599</accession>
    <name>A0A367J599_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002240">
        <property type="protein sequence ID" value="RCH84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J599"/>
    <dbReference type="STRING" id="86630.A0A367J599"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="1">
        <location>
            <begin position="182"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="384" mass="44572" checksum="E413F1418D30C830" modified="2018-11-07" version="1">MVHNDERVTDHLVFFIHGMGQQYEKYGNMKHHVSTIQKNTLDILSSYYPQYEKHIRVKYIPIEWHSFIHDMIDSKMNKSTLTTVPKVRLAANHWLMDCLYYFTNPYGQHIINHVVKTCSKAYEDYVSSHPGFNGHVHFIGFSLGGIIAYDIASMQWSEHEDGLPPWAKGDVSNTPDITVPPLGFKIKSIFTCGSPIAAGLICRGLDYLQFRPPPRTRIHNIFHPFDPLGYRLEPMIHPNYDTVEPVLVDRTKRLPRIPNLGIKSSIATAKPYIQSFWQSFFTVKTESVVTYSDHSLKRKEEELDDDGVRKKRRKMIHQDNTMMIPKDGILGTDGNMYPRLDYVLSENMIDAYASEWIVALKSHFRYWANRDVSHHIVKTLLDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J743</accession>
    <name>A0A367J743_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002070">
        <property type="protein sequence ID" value="RCH85551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J743"/>
    <dbReference type="STRING" id="86630.A0A367J743"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="19225" checksum="4CD40B002E8E5FC1" modified="2018-11-07" version="1">MISLASAHHFEPRNINHLIAYTASNVKTLLECSKERSHYQHRLLPTLHVFIKHTFYHCKLTPTILVVALIYLGRLKSCLPHQSKGEFDTPYKMFIAAVVLASKFIEDSNSIVQSVHKFVSPLYSPREVNEMERSFLAVVKYNLFVNLIEVDQFIKQYKDSLEFALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J770</accession>
    <name>A0A367J770_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS5_1</name>
        <name evidence="6" type="ORF">CU097_003632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002022">
        <property type="protein sequence ID" value="RCH85750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J770"/>
    <dbReference type="STRING" id="86630.A0A367J770"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="45"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="216" mass="24225" checksum="990005A14F748EF9" modified="2018-11-07" version="1">MPALGLPANVSATADGTRKLFNKWSYEDVEVKDISLQDYIQIRQHVFLPHTAGRFAVKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAARIVQHAFEIIHLLTDANPLQILVDAIINCGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAISLLTIGAREAAFRNIKTIAECLADELINAAKGSANSYAIKKKDELERVAKCKLIVLFVLLFLTYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7N3</accession>
    <name>A0A367J7N3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001971">
        <property type="protein sequence ID" value="RCH85964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7N3"/>
    <dbReference type="STRING" id="86630.A0A367J7N3"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="139" mass="15208" checksum="0274F54C07913CA2" modified="2018-11-07" version="1">MLRQPIQRITSSNLRNITLKSLTASYTTSLQPTAKSVAPTAEQAANRATTWSETQRAKADALKGPRFEQMDLSTQPNPMAAIELIAEEPIRFVNKRIAHCDGGGGPLGHPKVYINLDASGPQACGYCGIRFQKLDDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J807</accession>
    <name>A0A367J807_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CYP15_1</name>
        <name evidence="11" type="ORF">CU097_003125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001948">
        <property type="protein sequence ID" value="RCH86063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J807"/>
    <dbReference type="STRING" id="86630.A0A367J807"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="485"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH86063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="629" mass="71656" checksum="234A371CECEADA72" modified="2018-11-07" version="1">MSQDSTANDNNKRSFEEHNIDNASDDDIGPILPPPSNEEIPRKKKRTLAHEKLYLDHLPSADMYEKSYMHRDVLSHVAVTKKDFIITTSVDGHLKFWKKTATGIEFVKHYKSHLSSIVDISLSADHELLATVSDDMSMKVYDITNFDMINMIKLRYKPKSVCWIHQRGQAQALVAVSEADNSNIHIYDGRADGKPLHTLSKMHSKPVHIIEFNSKFNCVVSVDSVGMIEYWSPEPPFALPDNLDFELKSQTDLYEFRKKKSVPTCLTFSRDGLSFVTMSFPDRQVRLFKFLQGKMFREYDESLQVISEMQQAGTTIHKLDDMEFGRRLAVERELEKSSQSRFVNAVFDESGNFIIYGSLLGIKIVNIRTNKVVRLLGKSETNRFVNVSLYQGAPKKKGIYTLAMVASENAALKESQELDPTLFCTAFNKNRFYLMTKREPFDDINQKGERDIFNEKPSREEQTVAATQERKQILGTSAILRTTSGDIHIRLFPDAAPKAVENFTTHAKNGYYDNLIFHRVIKGFMIQTGCPFGDGTGGESIWGDDFEDEFSREYRHDRPYTVSMANAGPNTNGSQFFITVAPTTWLDNKHTVFGRVTAGMDVVHSIESEKVDKTNKPLEDIKIINIDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8E2</accession>
    <name>A0A367J8E2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001919">
        <property type="protein sequence ID" value="RCH86198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8E2"/>
    <dbReference type="STRING" id="86630.A0A367J8E2"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="534" mass="62065" checksum="4E288C1A369C1DEA" modified="2018-11-07" version="1">MKGHSFGNDQPFPFRPRTKPVNLMASSLPLHQHIPRKRLPSLLSTHKRALVLFTFTCAIYYIFSSSAQNLSSQIDYNINPLFWAPRISLQDKDSSAYPSTFFTKDALWENELKPVSAIVLRVTDDDQSIINTINHLLKYPYISEIYIHNLVSNRPLTINELKVDSKISIPIEILDIKHEQLESMARFTTCATAVQSYCYFQDDTFINRAMDSLYTNFLRFPSIIHANTKPTYYEKEMKWRFYNKDIRLHTGYADLRFGAFVSRWKVQTFLTQLGKSGLAKENIREAEHYFAIWMNQYPWLLSNPPYLANGQKATDYDVKYPAALDSFTYDAVRYLQWSLEQNEQTYFEIEEEEPPLAHRDVKSSCVNDKCLLITSMDSYVHPERIPFDYKTIASIEQLETLYDKLSTGTEWVQHSYHLAVDSDPTTCWDTLRAPKKGDYFGLMLVGSLKTDTLTIYTPNEIKRPEKQFLVSVMEEGSNQWTKCKATQIERSYNNRIQLATDCPVDYYRLIKVSFNSDLSVPFKLCSLSLDNFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8S2</accession>
    <name>A0A367J8S2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001931">
        <property type="protein sequence ID" value="RCH86141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8S2"/>
    <dbReference type="STRING" id="86630.A0A367J8S2"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34389" checksum="A0DC8CC782FE466A" modified="2018-11-07" version="1">MILDPRSPPSPPPEDDPQAGCKLMDTFGIIVQLCLAAAAFSTLIYKRQREKPRRPLRIWGFDVSKQLVGGIIVHSLNVVAAVFFGINPEEGVKANPCVWYFLNILVDTTLGVGILWLILTGFKHVIAKLGWVGFQSGIYGDPPFTQQLKHWLKQLAVYIISLMLMKVIVVVLFHLCPWIADFGEWVLEWTLGNYRLQVVFVMLIFPLIMNILQFWVIDTIVKHKADKDSSTTIRLQADEEDAQRLLRHDESEEESLSRSTIQEPPPKYSMDDSGSFLSVHDFQQASSSSPIHGNEYELESKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9Z3</accession>
    <name>A0A367J9Z3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCNYL1_1</name>
        <name evidence="3" type="ORF">CU097_008294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001799">
        <property type="protein sequence ID" value="RCH86763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9Z3"/>
    <dbReference type="STRING" id="86630.A0A367J9Z3"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="645"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="754" mass="85324" checksum="22A25310EE18B66B" modified="2018-11-07" version="1">MSSLPVKMNAPIFKSSTIVELQEKLKINKVFHKSLSEDTVKDVQALIQYWNMKHALNVSSTSFDNSKNSRFFKTGNKIEPQEFSDVISNSIQPNKEQLAACTGIYELPSTCLETSSVKSSSDIRSYESSKHPSSTFIECSDIEPACSDNAEPTHSSSEEHSPSTESETTADPSSKKKALKAKVQTFFSKIKNAFAKRSSKAPQRSFSCVDPISGPIDLSDSEYLEFVFNDIKQPLTPHIKAMVQRRKFNTFQELRCFVREWKEEKQNVREAFDRVGLRHSWEPKITDDGSYYAPSEFGWSVFWPNGGPYPLPSPCRLSLEGSSLYESRGAIDDGPGDDNASFFDEFEARQLAGDFSYMDYYVDPAMADDGSESGSSCGSPYGGPEHLDSETVKGYSPEKRSSVDQLMQDIWKRSEEYQEYFSSKDTEDEDLDDGFVAGDGFDAGGDFGVGAGFGVGGDFGAGEGNDDGDDYGNEYYGMHLRLVSDKRNVSSSIWNPPTFHAAIGNNIRVPHSQTEVDIRLQDAVPYVKIDGSHSQEHKIPRKKVKQLMVDIDDGALYKRSISAYSSFKDYDLVWQKTFHEEQQDVDKSQVTLQSVALALYELIQKNHYEGNFECDPLFISPEISYEDDMWEAEPLTEWTDLFMEMANIFERASLSSEHAIISFIYLKRMLSISGQCLFDGNWQRLLMLSILTAAKVWEDCSIYNSDYPQMFPDVPTKTINQMEIHYLEYLDWNVNVKCSEFAAAYFYLRQFQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA04</accession>
    <name>A0A367JA04_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RHO1 GDP-GTP exchange protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ROM2_5</name>
        <name evidence="7" type="ORF">CU097_005932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001820">
        <property type="protein sequence ID" value="RCH86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA04"/>
    <dbReference type="STRING" id="86630.A0A367JA04"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="241"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="647"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1019" mass="118465" checksum="E70D774DAA043D40" modified="2018-11-07" version="1" fragment="single">MAQRSNSFAYGTKKSDTYIPPTVYPALLSKVANELKRHITVSDHIKDDIEYKNTFHGREIVDKLSTILHTRDRKLALRVGTSLASQKLFHDVCYETRLVDSIAYLYEFSFNNQTIYQQQSDSLSEIESNRSFNEQPVVMENNTINGVFTELTYCYSPTCWDNRPCYSPTCPKRIMQLPLEIKDNIQSITKSTYPKQQQHQQQQQQQQQQLPSPQQQQFDHGLWANTVDKELYDTIPKIERKRQENLYELIYTEEDYVESLNYVQTMWIKPLKERPIIPTARKEIFIQKVFRNIASIYEINTRLLHALKARQNENPVIYQVGDILLDFVIDFEPYIDYGSKQHEAKYTLENERFINANFEAFVQTTERHPSSLKLELNGYLTKPTTRLGRYTLLFNEILKHTPTGHPDKEQLPKAINIIKQFLSRVNYETGQAKNRFDLERIHYNLSFKYKTDEINLDLLAKNRSIIKQGTLKKTAQPDSVEYQVILFDHYLVIAKLKMNNGLERYVIQRRPIPLELLHIYLPRYDPSMHNRRSSSLVLPYLTNNNPNNTMMVASAGGSGMHVRASTDIAAYMNAQANTEMDEENNSCYPLTIQHLGRPSLHITLFATSPAIRKSWMDKIKSQQEELNKKKPVFETVPVFNGHEFLEINKINHFITFNAGQQYLLAADDGVYVGHHHYKHLDTRPHKVLSLERVTQVQAIECNQTLLVLADKSLWEYPLDVVNEKPELQPQGRLIQTHVPFFYYGTCLQKTMVCIPKISTLSSIISAYEPIKRIYDTNATPNLQHNVNTGKRQNLVNKILSLRSSTSLGHSNLRKVKDCYVPCEAYAVELSATMMLITTSRGVIMIDMRTDQPQQLLNPADKNLSFIMEREKEPTTLNLRQSTKRIAIFRAPRNHYFICYDEYAFYIDSKGNRLFNKFLIEWEGNPESFAFSYPFAIAFHSSYIEVRSVITGAIEQIIRGKQVKCLNNGHKTELPLIFGTMMDPQNGKYRFVFKLQMVDDHSRTHDTFSEPSTIREKTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAY6</accession>
    <name>A0A367JAY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALG3_2</name>
        <name evidence="15" type="ORF">CU097_008334</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="PJQL01001732">
        <property type="protein sequence ID" value="RCH87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAY6"/>
    <dbReference type="STRING" id="86630.A0A367JAY6"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="458" mass="52774" checksum="95C53BCD0159981A" modified="2018-11-07" version="1">MTEKRGSYFGVTSISCLQEGLNRVLRLKDWCEAMPKTTTRRKPISRRVYGLKDIKNTLARFLCDPKYFWHLAGLVLVGEFVLSTLIVQKVSYTEIDWKAYMQEVEGFLNGERDYTKLRGDTGPLVYPAGFVYIYSLLYYLTNRGTNIRTAQYMFEALYLINQSIVMGIYSRSKKVPPYVILLLACSKRFHSIFLLRCFNDPVAMSFVYACILAMTYRRWTLGTVLFSCALSIKMNVLLFFPAFGILLWLTLGAWKTVGQLGLLAMTQGLLAYPFLASYPKSYFSKAFEFGRAFDYTWTVNWRMVSKETFLSDWFSKLLLAGHGGVLFAFIIHIWLKPKGGLLSVLKRGFAGGSVVISNDDIISMMFTSNLIGILFARSLHYQFYSWYFQTLPYLLWTSELSISQFPVTKVLILATIEMCWLTFPSTKQSSYTLLVCHFMLLVGIYRYHLSREEVKVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC36</accession>
    <name>A0A367JC36_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001688">
        <property type="protein sequence ID" value="RCH87291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC36"/>
    <dbReference type="STRING" id="86630.A0A367JC36"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="9">
        <location>
            <begin position="280"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="472"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="658"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1124" mass="127279" checksum="16A8DEE6203F7F5C" modified="2018-11-07" version="1">MTILTCQKTLLFFSYFSSTSKNMSALENATAPTNVNPPLEMEETGRDEKERQEKNKRDLGEIQDKAHTSKDAQEENTEAEKAQQKPGTFLDASGQAHPNTEKPPEHEEKQVFPEQHDPNAKVWSNPEDSNEENAPWKPNVHPSNGNIDNHVQKNVMDNRQLYREPSVVESTVSDIKTIFDTDDNEYRRASPKQKLKHATPLHPTQPDVLIEQLQIKALKYIIIACFICYVVGRFKYGIFFGFTMIGLCAWAYWNLGRTSSDGLEWQLEKQENMKTLYTSEGETVEWLNYMVEKIWRSIDPELFTIVEDLLEDAIQSVAPSIIKGVKVSDFDIGMQAPRIQMIRVFPPLPGQPEESIFGEASFSFHAHPVASLATNRSPKSTPPGLTLRFLTAVGAPIEVKAELTSLSGKIRFKLLTGPEIPFISKATIAFTSVPKVETGVMPLTKHLNIMNLPTIKALVNEGLKFGLADMVDPKSLTIDVRALVGAFARDTNAIGVVKVEVRQASRDPSIHLQDLKDSYATLSLSTQPKKSISSTRVLTNDIDPRWNENLYVLVYADDIVSETQVDIKVWDADKIKYDDMWGSVSMSVKDIVQGKLDKLGNVASWSQDERVVFDGWTPIDGKPIEESKVRLDMKLSFHPKYATPSTDILSKKLPQDNTSKDEKDEEQVQPEHSNGILSVTIHQASDLEIADPAILPSDDRFKHPYNPSSIVSPYAVLYINDNKVFRTRTKLRNPCPHWNAITEHFVRDIDNAFIRITVKTALEFERDPVLGTKVISLNDLFTDQDAKFKEAQKWIPISDGIGFGKVLLSLKYKPVKMTLPRSLQGADVGTLVVEKLTLDRLNSPLDSTAASPTKATLAVNVDPAIIKRLKSRDIQVVDNLSGWYDRHLYFPLMMRYRTALYIHISQGALTNTKATGRIWLKDIVDNEWQDVVVGLHRHISEKTSDANKNEDAWPEEGDLGQVRLRVKFVPGFSPVHTHLRSFVKDMVGADPFYSDTLKYKAQKWIREQSKDEGNEPLDHDFQQALQEEKEKMKDEERRRSSEASSEYGEEESDDELDEDENGADIDDTELKADMIEQRKMNKVSKHRVIRKLAWSVDKVKHKVDVLREGFNSETRAKRSVAKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC54</accession>
    <name>A0A367JC54_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001642">
        <property type="protein sequence ID" value="RCH87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC54"/>
    <dbReference type="STRING" id="86630.A0A367JC54"/>
    <dbReference type="OrthoDB" id="2538345at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689:SF1">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="26964" checksum="B9876FD1DE40851D" modified="2018-11-07" version="1">MATSRSSRVHSKHSSSKRRRSESPIKYKKKKKSSSSSSSSSRESSPDKRYKRRKKHKKSKKSKKKSKSLSIGDQWGKYGIIYESDIFTKEPEFQAWLIEVKDADVETLSQSKRKEMFIEFMEDYNTATLPHKKFYSIEKWEKRQQAIRMGEQYVEETFDFAKDEERLRQHHKQAAKAAAASRQPALQLSEDQIKELSRVNRERIEADRMRKMGLTPKEGMGVRYEEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCB9</accession>
    <name>A0A367JCB9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001642">
        <property type="protein sequence ID" value="RCH87509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCB9"/>
    <dbReference type="STRING" id="86630.A0A367JCB9"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="187" mass="21369" checksum="25788B9975D9AEB7" modified="2018-11-07" version="1">MLQKKRHAADDESTINVKNTEGNVDYLSYNFDEMDLAASWRVLTKQKLNIINGIRLENASWRTWAKQRNNLKTVSPETLNCDVTWLYGPLHTVMKQDKKHIRPLPSPLQKPQEKPLKSALKKVTMSDLLKRSASELQIHQNNPKKKDDDLSASSSLSISKVNQEVGAFSPSVIANHRQPKLRFNQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCK4</accession>
    <name>A0A367JCK4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001626">
        <property type="protein sequence ID" value="RCH87589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCK4"/>
    <dbReference type="OrthoDB" id="2220587at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="209" mass="23796" checksum="7DC732833CE909C0" modified="2018-11-07" version="1">MNNNEEPDNDDIVLFSSGLQESKDGKLITTTEHLYEQMLVFNQKLEELADNDLPRMIKNTKREAIKKDLSEWLPAFFKNVAANVSLVGSKDVDLLEGFEEPFDESLERKKKDLEQQFNSLLEKRIHARRNIYDQVNLILQHASNNVSHTEDTTATTQSSPQLPDGSSLDSAEWDELKAEIGGMMTHLTNLSGNIESLIKEYEQVESIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCP8</accession>
    <name>A0A367JCP8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine-5'-phosphate glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001603">
        <property type="protein sequence ID" value="RCH87718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCP8"/>
    <dbReference type="STRING" id="86630.A0A367JCP8"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH87718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="35715" checksum="96A3F2DBE8240D1F" modified="2018-11-07" version="1">MLWTKQRALFTRLAIHRFSALSIAEKFTITPEIKDALKRNGPVVALESTIISHGMPYPQNVETARSVEAIVREQGAIPATIAILNGKVHIGLNDDQLDYFGKNGPAAIKASRRDLPVILAQGKSGATTVASTMILARAAGIPVFVTGGIGGVHRGASESFDISADLTELGRTPVAVVCAGVKSILDIPKTLEVLETQGVTVATVGTTRQFPAFYTPNSGFDVGADMSPYHIETAQDAAKIILANHELQMNSGIVFAVPIPKESAADTKSIQEAIDTAITEARTENIKGKEETPFLLKRIAELTKGESLSANIALVKNNAKIGGQIAVQLSQLKQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDD3</accession>
    <name>A0A367JDD3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001553">
        <property type="protein sequence ID" value="RCH87982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDD3"/>
    <dbReference type="STRING" id="86630.A0A367JDD3"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="188" mass="21001" checksum="E47DBE96875577D1" modified="2018-11-07" version="1">MVLVDTETIATDERIQLAINARDNLDIVKECRSNPELILHEAYSHFTESQREHSLTCSTLRGPDMIILPPLMFYNKTYTEMVSIIHFGKNLCGHDGIIHGGLAATILDEALAAVALPSLPKRFGFTANLNVNYRKPILSDQWVVVRAKLDKLEERKAFVSAHIESAEDKAILTEATSLYISPKSIPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEP0</accession>
    <name>A0A367JEP0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001477">
        <property type="protein sequence ID" value="RCH88377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEP0"/>
    <dbReference type="STRING" id="86630.A0A367JEP0"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="16792" checksum="17F6B86C5F957621" modified="2018-11-07" version="1">MSLNVSDPALIEAYEDVRDDKTETNWAFFDFANTKPDRLQVSGTGTGGLSEFVAHLKPEVAGWGYVRMNMSNDEYSQRVKFVLVPWCGDKVGVMRKAKLSIQIAEVKNVLRNYHIEVPASSVQDLSENEILTRLRRAGGANYDRQSSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JET0</accession>
    <name>A0A367JET0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001477">
        <property type="protein sequence ID" value="RCH88379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JET0"/>
    <dbReference type="STRING" id="86630.A0A367JET0"/>
    <dbReference type="OrthoDB" id="201709at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19372" checksum="6636196F1D3B8179" modified="2018-11-07" version="1">MFQSKAYIERRHGKNSANRSEYLEQLINEYKTTKDKVAKQQVLAHLANFAYDPINYDHLWNLYAVDLFLEAITDPDPLLREFGMGGLANICLEPRHYEYIMSQPSFRQNIISCLDNTWTKNIKVNAMTTLMLLITEENYSESFAKYQKQRQRQTDYYASFFIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFS7</accession>
    <name>A0A367JFS7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NUP84</name>
        <name evidence="8" type="ORF">CU097_006308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001416">
        <property type="protein sequence ID" value="RCH88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFS7"/>
    <dbReference type="STRING" id="86630.A0A367JFS7"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="656" mass="76747" checksum="4F577556809DECEB" modified="2018-11-07" version="1">MTIGNNNNNFLDNYARIFKLYETNNGHDIAMKYASLNLDDKDMFRQAENNTWKLIDAIISSKDKCCLFQYAALKDWISKTTVSQELRSQIMRKVSEEEELEEELMHIVYRNQALSHPSKKRKVSIDIEAVYKQRWNKIRSGVYEKTIGEPGEDPTAVYVHNEYVRFNLFALGRDSSGYSQKEWDSWFECVQYMAKNESLGFYEKLLYDTFAGNTHIGPSICQTWEDVIWVNLNSVVQNAMTKQDSEKLILSDSVAQLALSKDYLLEEGDPRKFFHLVQLALLQDRISDLIDTAYEHFITRNSFFNLGKEHRIEALRFISTLLIYGRQYLDWKQDEKSIAIVSYYAELSSARDYFRPLITAIYASKLPLDAQVSVYSRFLEEFDGDKEEVSILLLLGKQQGLAMNDILKQVSSNTLQKALYESSKVKSLQNYRLENDEVDDFAYTLLDALGWLKSQDLCLELFKTANMIIRQILGMRRLYLVERVTDVVEEMEMYCSKTKDMEKEFAEYLSHKRLVNTFKLFEEWTDLIQSSPQDSGSLSDLQKVVSWRHEVQTQTEILERELRFLLEGGWLGEHTDETRHISKATLREIYIPDLVIKYHQLLHLSSSVIPENLQKSRQMNTYVTVKHRELYDDIMVANRMKQVIKEFSKSLLPMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGL5</accession>
    <name>A0A367JGL5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001361">
        <property type="protein sequence ID" value="RCH89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGL5"/>
    <dbReference type="STRING" id="86630.A0A367JGL5"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="270" mass="30979" checksum="E7E2FAF98F15D1C7" modified="2018-11-07" version="1">MLPTSQPENYYATNYPPNSSSSSKHIAILYDDDDPSSDMMLTHETVNRYTPHVTISQKPVDLYPSQHSSALSSPTPFYFPEEQHPSTQKYESMFLAENNNSRPSEVTSVKQHLDDSFLMQHNQHMEQQHIHSNSEEGKEDEPVIGDGARSYSSVESSGSRRSQKLSKEDKRKRNTAASARFRIKKKMREKALQSTACEMTEKAKRMEQKVHELEREIKWLKALIVEKDDARLEELIKERPAVSIAFPMPSTSRQSQQPSEDEEDENSDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHC9</accession>
    <name>A0A367JHC9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic phosphate transporter pho88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001303">
        <property type="protein sequence ID" value="RCH89358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHC9"/>
    <dbReference type="STRING" id="86630.A0A367JHC9"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21965" checksum="932AAA6416A1CEF1" modified="2018-11-07" version="1">MGSPSIITNPLFNVGFLLVSMQLAKKVDWNDPDVLTMARIGYYSAQLLVVAMAYGLITLIRKKNDTTVLTYTPPAKPGFGAPAPSAPETVTTTIRDYDIDQVKQFIQSTLTSVLIISLMHWQFKFTQPLLMQSIMPIKNFLTHKEALIHLWGDKPEGSLARPFTVDNPLGGLASLLGVSDPAAAPATNNTSSNDESHAHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHG9</accession>
    <name>A0A367JHG9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001310">
        <property type="protein sequence ID" value="RCH89319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHG9"/>
    <dbReference type="STRING" id="86630.A0A367JHG9"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="81"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="779" mass="90264" checksum="722B34FD5304E220" modified="2018-11-07" version="1">MHRHRPGSLHQSNKPFKSRHATKGALKEASKGKVNRASIKQSGGMKTLSKADRRHAAKILQQKKREEITRMSRIFEGRQGAPKIVPVLPLCPDSEVHTAIAALYKSLGQEAPKHASEEPTVLNVERFKQKIQLVPLTKRRFLDILDAFKVADFGILLMSADVEVDQLGINCLLGILNQGIVNVVPVVQHIERVQPKLRTSTKKSLTSFIQQFFPEEEHLFTLDTDTDAMNTLRFITSQRPKPMSWRDHHPYMLADEVTFDSVTPERGTLKVTGYARGNPFNANRLVHLQNFGDFQIQQITSAPLESHQGDMEVDAAVIDTPKPDEQDDLIAENEPDFMDNEQTWPTEEELAEADERVRRMQAMETDGNTKRVPKGTSSYQAAWIVDDDDQNYSEDEFEDENENDAMMTEDADDDIVEPAYSSFPPEEEYEEIQMDSKEQYKDELDAEEEARQYEEYLKQRQKDYETHNEFPDEIDTPMHIPARERFARYRGLQSFRTSPWDPYENLPVDYARIFQFENYGRTKSRVLNQAIVGNVKPGSRITIWIHNVPIEAFQSYDRTRPFIVFGLLQYEHKMSLLNIQIQRDNAYEEPVKSKDPMVMHMGFRRYNVRPIYSQNTNKGSNNVHKFERFIQLGRSYVATVYGPIVFGKTPVMFYKETENKNEPILVSTGTFMDVDVKRIIAKRIILSGHPFKIHKRSAVVRYMFFNVEDIYWFKPVQLTTKYGRVGHIKESLGTHGYMKCVFDGTLTQQDTVMMCLYKRVFPKWNTELYRDESSQIDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJC4</accession>
    <name>A0A367JJC4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001195">
        <property type="protein sequence ID" value="RCH89985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJC4"/>
    <dbReference type="STRING" id="86630.A0A367JJC4"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="565" mass="65415" checksum="571C0DBBD1B52283" modified="2018-11-07" version="1">MIPIAPAIKNYTAPITLDFKKTKRRRAKRSCDYCRRKKTRCDGDTNHPCSKCRAANVNCLFLTERKKRGPAGGSYVELLENRLKRMESLLDDSKRIQHKHLQDIEYPGQNTCEQLFQKSPDMDAVEQQMSGLTIKDYQRTRYFGASAGIHLLEKNVLFRNKKLHFKREPSWFIQKVNDDEEEHVIVKSEEVYQPQQINVVKGPLSTRIKLFEDVPLMTPELLDLFVYLYFTQVHIYGPLINKVEFLEQYYFQNPSAPDEYLLYAIAYIGSQLFTPKESEMAKSDMTRIQECLKDKAFQILGIVYKRPYVSTVQSLLVLTSHVINDQEVDDEDTGHWIIAGLAIRLAQDLGLHIDCSQWKIPPYEIELRRRIWYTCYFVDRWIGAQLGRPLSIIDDDFDVVLPTPYELETKVARTRSEVTPILLVEADSALQQRLPVYNHFSYLVTLTHILGQVLIGQYSTLNKRNRSVEFVNCMEQNLHMWRQSLPKEMFSVHDKHHAPQYSLMQLAYYTVIIFIYRPFISTAAENKELAFKALGICTSAANSLMNAALSVDNCSLANAPWNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJI6</accession>
    <name>A0A367JJI6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001176">
        <property type="protein sequence ID" value="RCH90103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJI6"/>
    <dbReference type="STRING" id="86630.A0A367JJI6"/>
    <dbReference type="OrthoDB" id="2290708at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="311" mass="35756" checksum="CB2E85F1BE287371" modified="2018-11-07" version="1">MLQEYPTQVQPRSSSTRDTQDQDVDSSNKLDAEAGRILIDLANQDTSLRNSNGDVGTSIKANHILQRLQPDPIMLLAAAAAVIDDEGKYKGRSYERREIKLQTRRHSMSTTKRKSLTTTTESYLYRRTSERRYRNQRPSLTSQPSSDTWMPTRTITPEDEDEEMPLKGESQHTFSWQYLSMKQNPRIKRNAMHAYITYMIYTDMANEQRTKQNHKSNSTNSSNSSSSNSSHHNHHKNVYSKDVTNNNNNNWYMQSYRLPPSPRQRHDAVLAPPTDTPNNNIIGRPLTDFLFDNHRPSSSSILPPPNNARAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKZ0</accession>
    <name>A0A367JKZ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein sey1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SEY1_1</name>
        <name evidence="8" type="synonym">SEY1</name>
        <name evidence="12" type="ORF">CU097_003654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001098">
        <property type="protein sequence ID" value="RCH90598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKZ0"/>
    <dbReference type="STRING" id="86630.A0A367JKZ0"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="701"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="725"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="61"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH90598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="769" mass="88392" checksum="800071D90AF6286D" modified="2018-11-07" version="1">MEAKPNEEQSVEVKEVVNSTPTEDWDSDVAEIPRLQVIDEHQKFTEQLPEYMGKWGLADAGFKYDVVAVFGSQSTGKSTLLNKLFGTRFAEMNENQRQQTTKGIWLSRGRGMHVLVMDVEGTDGRERGEDQDFERKSALFSMATSEVIILNLWEHQVGLYQGANMGLLKTVFEVNLQLFQNQRGKEKTLLFMVIRDFVGATPLENLAKTLRTDLEKIWESLSKPEGLEDCKITDYFDFMFTGLPHKILLPDKFDEEVAKLRKRFNDPNHPDFVFRPEYHKRIPADGYHLYASSIWDKILTNKDLDLPTQQELLAQYRCDEIANAAFVVFQEGTALFKSPILEKGEIMDDLGERMKKLQQEALQSFDKSASRYNQGVYQRKRVEMVTKLNTQLGVYFVGQLKNLHKKAIHLFNDKLQQELKKPKYQFAEVVSSCLKEATAFFENGAKAMVIEGTDWSYAHEEETLKEELNELAAKARTKEFTKMSKALEKQIETELTDPVALELNRPGPDMWAKIISIYNATLADAEKVLAKQAESFDLSTEEAQASAANLKRQTWLVLRKKIDEELADNLLLLKLRNRFEEKFRYDEKGLPKVWKPEDNIDIHFKKARDETLSLIKLFSKIDTSSDDEFKIESTEEFDFEQSLIILGEGKQIDISNRFKRESDAFYLEAKRSVVATTAKIPTWAVIAMIFLGWNEFMTILKSPIYLVLFILCVSVGYVVYALNLWGPLERILTTVFNEATSMAKNRIAETVHASGSGRSQYEMKDFKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMU8</accession>
    <name>A0A367JMU8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000996">
        <property type="protein sequence ID" value="RCH91262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMU8"/>
    <dbReference type="STRING" id="86630.A0A367JMU8"/>
    <dbReference type="OrthoDB" id="2153288at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="541" mass="62481" checksum="3C7979C27A630B8B" modified="2018-11-07" version="1">MEWRVYIMSIAGVAMIYLTSLLLYDVPYPTPVYIPHVEKSKNGVSDQVILTAKKDYIYNTQLVFDQERSESYFYSTSALKVGTFGRIIQTKKLKDGLSQPIETEWKPCFNHTIDGTIVNVSESPNDGLIQFAVLYRRLEKDDLLHYVRVYYFPDQDDDMQYKDLFIPGTTLVKEISLEDDCILLHRDPDNYRFRIIPLPQDITAPPHSEEMGVIYIGQTTPGDPIRAYHQPRDTEAHAGLLSRLYSPNPDIIRVLTLDIYQTTQDYYINLTIVDGTPYTKDRQIGEWIRQGTFKNRERFPRYINSVPEFSHIDTYQHPIERIENPMPVPFMTRSSHGKSLVTSIAKHFYTFDFTNNITNSDHLYKHINGTVMSEAYNDAEDDTMVDDSDIVGLKLNEDATLLAVWTETQSVYIFKRGVSDSEDASMGKISPHNLRRSLRWKPRMVIHPVDSKLGVSYSILGYFWLTLLLKKVGSVLFWKNKTGNNYISVGMKSTEVNTYFIDEYGEVKEWSFTNFVKDRYGLVCLMLAVVALFAANEHQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMV1</accession>
    <name>A0A367JMV1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000994">
        <property type="protein sequence ID" value="RCH91274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMV1"/>
    <dbReference type="STRING" id="86630.A0A367JMV1"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="511"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="560" mass="63770" checksum="940ABB60B665B58C" modified="2018-11-07" version="1">MNFTSTISGNKALATKAEPSQASRSAARDADLRRRLLQKQHQVAQRQQQQQQQQPQDTAPPPSTNTNRKLDPLEIQHKKKLFQKFKFFLYKIDPDLESKIARKILLLGATREAFFSSKCTHVITTSKFIPAKKDAASTDTTSMSDPKDSMDPTIQNAQKLGLSIWSVEGALKIINILMESSTASAKAHERASIDTNGRDKKPTFVPFTGYYILVEDATNVHCPVLIKEYTKETFGEKPKVIPWPTLRKKRTKAQADAKQNREQPEATQNNNDKNEKQKETTAERKKNNENKQSSKHDDDQKTHKKNDHADSTNKEADKEVDSHNHIDAKLNKPNDDTHTEKKKPIDNSNDINTKPKNSLDNNDKKTDNEKDECKSIQVESKQESHISASKPELTNQDKESVCPRRSQDDAATADASNVDKTKGKDVTDQEETQKQALKRKRDSTQEDASPATNNDNKLNQTAKEDTQEAKRQRCSNDDNNQPNVNKEKEADNVKKSKEHQEQNQKGEKRKRDVDLQYCENCNERFSILTEHIKAPKHLAFIKNVDNFAELDRVLKKVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN16</accession>
    <name>A0A367JN16_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_012037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001022">
        <property type="protein sequence ID" value="RCH91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN16"/>
    <dbReference type="STRING" id="86630.A0A367JN16"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="319"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="764" mass="79245" checksum="D6EBEA9927144C40" modified="2018-11-07" version="1" fragment="single">KRSQRSKNKSDSSSNINFVFNPDQPLSRSLSFTGSAPTSPAASATGFNIAGTASSASSGFGSGNKQPFVFGNASSTQPSNAFNFSSPGSQTFPSPLKRGVSELPTSGQSDRNNALRRSTSEFSFSTTSNPSAPNPFGTSLGAAPISFGTPAASNTPGAITTSTSGFAPAASTTGNAPAFSFAPVTGSTSATQAGTSTPAPAFTFGATSTTAPSTSSGAFNNTTSTAAPTSTSTTQTTDAFSFGSSTAKPSTTTTTTTSGFTFGKASEPASSTAAPAFTFSKPAEAPPAASTSAFSFGKSVEAPKANPAPSFSFAKPAESTQASQAASTTGTASTAATASATTTSSSPFTFGGLGSTSKPSTTPATTSFTFGTSTSTASAATTTTATTTATTATSSAAPVFSFGATASTSKPAPSLTSGTPTSTSSIITSSAPTTTTTTTTTAATTSSSAPTFSFGASTTTTEKKDDKGSAPIVTSNPFTFGTTASTSTSSSSTTPGITTNAPTTTTTISQPVEAKPNPFSFTKVLDDLSKISTQPPSQIYASLVTPSLASLYQTQVVHHTNFRIDNITSTTRFTELPEQAQKELDEVEKYIRLESQRSEYIRNHKMPQQTQLINKCKEDIEALSQKMDALSSMLKMRLESTESLYDDVKEQLRHANDGCAVIEACRHPGTAPRWLFGRSDEDDYFSLLAKQLASRLEEYKKCIWEIERTAESWSKNRAQSPQDIARIMHAQNQTFLALANKVASLHEAVEREKEYYKQYFKVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNG4</accession>
    <name>A0A367JNG4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_007283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="PJQL01000964">
        <property type="protein sequence ID" value="RCH91482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNG4"/>
    <dbReference type="STRING" id="86630.A0A367JNG4"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH91482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="227" mass="26121" checksum="56E1CF9A6A4DFEBB" modified="2018-11-07" version="1">MSKGSTSSQSNERPPAPPGPKNFVEWYLLSYNQVSFLGWFWILYLTVSELYQKQGDYRGVFDLVWPSLSYVQTAALFEVLHSVLGFVRAPIMTTLMQVASRLFLVWGVNYFVPEIHTHWSFSTMVIAWSIAECTRYAFYIFHLSGGGVPGLISWARYNFFLILYPLGVFSEMMMVYQALPYAKAIHPAYYFGLIAVALIYIPGFPVLFSHMLAQRRKYARGDLKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNJ8</accession>
    <name>A0A367JNJ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_001926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000992">
        <property type="protein sequence ID" value="RCH91281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNJ8"/>
    <dbReference type="STRING" id="86630.A0A367JNJ8"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="32388" checksum="A573EA6F53424D25" modified="2018-11-07" version="1">MSERKVLNKYFPPNFDPSQIPRQKKPKDLQHKVRLMSPFSMRCESCGEYIYKGKKFNARKETVEGETYLSIKIFRFYIRCPRCSAEITFKTDPKNTDYVAEHGASRNFEPWREQDDKKESGDEEEENDPMKALENRTLDSKREMEILDALDEIRTRNARAERIDVDEVLNRFSNEDQAEISARMKEEEEEYEKEAKAVFESADGAQVRKIKEAEPDAISLVNQTKVAMDLPSFKPSVIKPTVIKKREPSKPIGVVVKKKQKQENGGALSMLANYSDTDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNM2</accession>
    <name>A0A367JNM2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000956">
        <property type="protein sequence ID" value="RCH91533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNM2"/>
    <dbReference type="STRING" id="86630.A0A367JNM2"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="400" mass="46732" checksum="00F92A2A43F9008F" modified="2018-11-07" version="1">MHHQYRTSIYNRASLLIEKARGPKWKRELVSDHKFDFIDIDEFYNTSCMYYIRYFGLLCSIVISALLYGADIWTACTLLIYDKWSLSTQPRIPFYISKWIYVGCIILSFILLAWEIRKARAVMATEDVSLAVTNAMAFRTYSLKSYTYFCLLQKIKSSTKWSDVMIFYVFYTLKGWKKIIVAQGPRQIIAGFTVYALLRSAWTKQGHFQFSVNPDDYGSDWQQRAAFISMSFTCILWIISMLNIGLAVILYFPILCHIQGNLKEYCCHKIDKRINEILAKQRKRRLKEAEKKKVQSVKKPSKDISNDGIKPTLPVIKDADLYTSVNMIDYYVYPQVNHMQAYDSHYATPLATPIEPVQSIQRKKTAHAYNNIGYTHHEYNQYAVYQKPNIAGEEKPMPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQM2</accession>
    <name>A0A367JQM2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_004328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="PJQL01000855">
        <property type="protein sequence ID" value="RCH92250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQM2"/>
    <dbReference type="STRING" id="86630.A0A367JQM2"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00300">
        <property type="entry name" value="LDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="145"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH92250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="32604" checksum="014BF3556A31C763" modified="2018-11-07" version="1">MVSHSKVAIVGAGAVGASTAYALMFKNICSEILIVDINPEIVQAQVLDLADAASVSHTPIRGASTEEAGQADIIVITAGAKQKEGEPRTQLIERNYRVLKNIIGSMQPIQPDAIILLVANPVDILTHIAQKLSGLEPNQVIGSGTYLDTTRLCVHLGEIFDVNPQSINAFVLGEHGDSQMIAWEAATIGGQPLTSFPEFQELDKQAISRAISGKAMEIIRLKGATFYGIGACAADLVHTIMLNRKSVHPVSVFVEKYGVTFSMPAKLGWKGVEKIYDVPLSEEEETLLLESVKALQEIERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQR9</accession>
    <name>A0A367JQR9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000851">
        <property type="protein sequence ID" value="RCH92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQR9"/>
    <dbReference type="STRING" id="86630.A0A367JQR9"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="433" mass="47660" checksum="DEBCD88F3314CB74" modified="2018-11-07" version="1" fragment="single">HQIRNSKATALVTVPALLPILLKVCDKIGLARNRVFLFGDKEVEGCRPFKSIAGTKPIETPIQGVDPNNDVAFICYSSGTTGLAKGVMLTHKNFISQTLLYIASDQTEIQNDCVLGFLPFYHIYGLNSLIITTSYKLIPTVVMPRYDIELMCQLIQKYKVKTAVIVPPVAIHLAKAPVVSKYDLSSIERLGCGAAPLGKEHIDALKKRIPVTVKQGYGMTETTSGVILQTTDHCSPGSIGILAPNIECKIVDENGKELGDDQEGELLFRGPSIMKGYLDNPKANAETFTADGWMRTGDIGKFDSKTQEFYIVDRIKELIKYKGYQVAPAELEAVIMGMDIVADCCVVGVYDDSQATELPRAYVVLQPGVERNEKTGALIEAFVAKSVTNHKKLRGGVRFIDAVPKSPSGKILRRQVREWVKKEQQETTARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRI8</accession>
    <name>A0A367JRI8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UGA2</name>
        <name evidence="10" type="ORF">CU097_012197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000815">
        <property type="protein sequence ID" value="RCH92526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRI8"/>
    <dbReference type="STRING" id="86630.A0A367JRI8"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="59"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="523" mass="56961" checksum="E13C426FE2C9ED7D" modified="2018-11-07" version="1">MIRAAVQTTYLKACLNPSRQPIIKKFNMSAMRSIVTTVDVPKLKDPSLLKHTAFINNEWTNKDVAETFSVLDPATDKEIGKLPDMGAKETREAIEVAAEAFKSWSTTTGKERHDLLLAWYRTIMDNQEDLATILTWENGKTLTEAKGEVAYGASFFEWFAEEAVRTYGTVIPSHIPHQRFITIKQPVGVVGVITPWNFPIAMITRKVGAALAAGCTCVIKPGAETPYSALALCELARRVGIPAGVVNVIPTHKHVADVGKELCTNPTVRKISFTGSTAVGKLLMAQSANTMKKVSMELGGNAAFIIFDDADIQAAIDAVIACKFRGTGQTCVSANRIYVQNGIYKEFSTRLAEKVSQFKVGHGFHSETTHGPLINDKSIEKVKTHVEDAVNKGAKILTGGKHLGGCFFEPTVLADMKKHMTIHSEETFGPVAALFGFDSEDEVISLANDTSFGLASYFFSRDVGRCWRVAERLESGMVGVNTGIISNCYAPFGGVKESGLGREGSQYGIDDYTHIKYINMGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRX4</accession>
    <name>A0A367JRX4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor synthesis protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MOCS3_2</name>
        <name evidence="8" type="ORF">CU097_013003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000790">
        <property type="protein sequence ID" value="RCH92710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRX4"/>
    <dbReference type="STRING" id="86630.A0A367JRX4"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="335"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="397" mass="43891" checksum="695C79A8BAF75AD8" modified="2018-11-07" version="1">MEDLKKENELLRKRVAELEKQLYAKAPTALTSQQKADTFEKVDKLTNQEIYRFGRQLVTPNFAQLKLRNTSFLIVGAGGLGAPAALYLGAGGVGRLGIVDHDEVDINNLHRQVIHTEARKGMNKAVSAAVAVKAIYPDADVIPYAYTLDRTNALDLIKQYDIIIDATDNITTRYLLSDAGVLAGKPVVSGSALRTDGQLTIYNYNNGPCFRCLHPIPPPAAAVGKCVDNGVVGVVPGVIGILQALEAIKVAIGSTALNDPSFLIFSAMSNPMFRTMRLRQKKKDCAICGESPTITELIDYVQFCQGEANDDVVSEHLLKREERIDVDEYDDILKNKRPHVLLDVRPKVQYDICHLPNSIHIPIDELDSKMDKVKEAMKEYKVTDKDDSSENDAKERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSY4</accession>
    <name>A0A367JSY4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAB1_1</name>
        <name evidence="2" type="ORF">CU097_001318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000754">
        <property type="protein sequence ID" value="RCH92995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JSY4"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1775" mass="200656" checksum="7A69DACBEA664EC6" modified="2018-11-07" version="1" fragment="single">MHFKTVSSPLSRQIVTDNNSEETSQLTLLDQAEQYGSEIIPSQKPPLAVPNMQIPTAALKQARGAYGNENTTTFALEIPIYGSESYPSSQLERPHSPFVAMAEQPTSPTLYNTSTVANTSSFNVTNTPDNHIYTGVKRLLDAGTSFIKPRPRSNTSSSAPLLEDFRSTQLPFRSVPYLDHGGGTVLAESELSSFPSAVVDPDEQYEDEAAGLYDRPLTPLKTPLYSDKPNSSNSDPLSPATNGGISDDESYDHRLRAKRTEELRGKNVQLISSKSSYHSYRRLSITGPTTPKLRNSGLHKINTVGLPKYDYPPSSAGPLQLEQTWSPNPLLSPYNDDANKFFPQSDNNNRFRFVPRQRRTSGPPPTVELSLSARQHARLLLRQFMQDIQFTESSKEEWEDVIMNILMKVANNVQPDTRAGDDMDVRHYVKIKKIPGGLPSDSFYVKGVVCTKNVAHKRMVRNMSSPRILILLFSLDYSRVEMENQLLSITPVISQEREHISKLVGRIVALKPSLLLVKSTVSRFALEFLLEANIPVIHNVKHSVIEAVARCTEAAIVTSVDKLQHGVSFGRCGSFEIRTFMHEWIPNRRKTYLIFDDCSPELGGTIVLRGEKVETLKVIKRLIDFMVFVVNNLKYETSLLRDSFAKNRGASESEERKRSPLMRQSSLGIEKLRDLEDDGHNYTELLLQTYQNTILSVSQFVIFKPPYLLLKLKETEERLAMVIQQKRKKSISCLSTLKDAASTVSTPAVLSLSASPTRATFDKQARSPMEKQQSMSHPASTSSYDTQEGDEFTSEFEQELITKSHQIARAWEAYHGETPESISPLYHQNIVVLYSSVCTVTTVPCQGPEIRIFGYYRIPSDKTLGQYIMDLCADAHQPCTSFMCDHPMLQHYRSYAHGNARVNVMIEQFPCPLPGMSDKLLMWSYCRECNKPTPVLPMSENTWNYSFGKFLEIFLYQEGVHCRADICPHDMAKNHVRYFGYMDMTVRFQYDPIELLEVSVPPMKLYIKSKIQRDLKEAELKSLRTKINRFYQSIVDRNKAFPFDLVDPRKLEACKAELQELSLEAQGEKKDTLQLLQNVYATSDPVDTLTINGVRRSLFQIVAHWEAVYADFVRFYLEPERELKKITTIHLRKMFPTDFSDMNTDERTKRATEVTDLPLLGIGLDDNDGDALIGRILKKKSTATIKPDEFTTRQNNDMVMPALSSTPSSTPITDMVEEDKDEDNMASSAQSDNKTSFLRPEIRRRLSLELMREFNEKLKYEEVTSAGAANTTNDISSFSQTRPNRYLQLRVSGSLSAAYTPSRIPLYSGKNNSPVSVYQQPSKQATTSINESKTAYKATVGPSSLSHVSSIEKLPRFPPHQRHHSIAHDYHIHQRYGKSKASSSFDDNDEFEPSPSFLRRSATSKDRRFRSRLPRKKTYIQVYDQANDLVREDIDDEFYPGDQADDTLSISSRQAAHRLKTDILLPRRKPTSYRQARHQRHLQLGYHAHESGTDADNDDDSDDEAEEAFDVGKSNVDYFTPIAPFTFEVLDESETNNKLEVENTQGKSDDGSTTNYAAVKPYFGLSDGQVDLMSGISGDDETDQDFLPLASDLLMAQQSANDALTISDLHNIHPELTTTTTNTSSSIRYITATANDENRHSPEKMSFMKTITNFLTDSGIGNLLPLESPLQPTEYLFPDSYVVVREDEPSTIIAYTLSSEDYLDKMHDIQNCHSESGMNDTHLKTYDSINIDRKAPSENYTFESGLHNNIPQVAEAIQETLLRESGSHMRYNFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT32</accession>
    <name>A0A367JT32_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000742">
        <property type="protein sequence ID" value="RCH93097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT32"/>
    <dbReference type="STRING" id="86630.A0A367JT32"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13467" checksum="2A9D47CA7EACAB30" modified="2018-11-07" version="1">MDENVSYLDLPKSFKVNQKTSTLDAETGEEEESLKEIKRELIDHAVSVEEIKEVLSQQYAVRDTLKNLYYSSKRVKVERTKQIQQKRFKLKLCTSEQRFISDQNGNNTILKSPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUG2</accession>
    <name>A0A367JUG2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Berardinelli-Seip congenital lipodystrophy 2 (Seipin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BSCL2_1</name>
        <name evidence="9" type="ORF">CU097_013425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000683">
        <property type="protein sequence ID" value="RCH93556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUG2"/>
    <dbReference type="STRING" id="86630.A0A367JUG2"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="41679" checksum="839B7F02FC1F1477" modified="2018-11-07" version="1">MSNSSGKAFSDTDDYSDQGVSSSDFHVVPSTGSQSFENEGGDINEKLIIGEEEEGEEEKIKPIEWHPALVMTGNLLKKLMSPIFKVLFAPQAQRTFIKTFVVVILVAWILLTSFTAYITFYQRYIPKNAHVEPIYFQYEKDSQPQAFIHFMQPDSNSMPLRSDQAYDVSVQLHVPTSDINFDIGNFMIHVDLLSQNGTVLAQSSRPAILRYQSNTQRILRVFAKAIPLLIGWTEESQRINVRLIEEFIEKKALPMTHARVALSTPKLQLYDAHLSVVADFRGLRYYMYHRRITTAFVFMILFTVIELICASIAWKAFGKNLWDKLHDAFAMEPLTAEELPQDQPQQEPSTQSHHTDDDEYLTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUG4</accession>
    <name>A0A367JUG4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase C-22 sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ERG5_2</name>
        <name evidence="8" type="ORF">CU097_005462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000681">
        <property type="protein sequence ID" value="RCH93567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUG4"/>
    <dbReference type="SMR" id="A0A367JUG4"/>
    <dbReference type="STRING" id="86630.A0A367JUG4"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="724" mass="84340" checksum="B8282E6F55ABD1AB" modified="2018-11-07" version="1">MQQQRQNIILYPTPETHDSIHTNDNHRIHGTSSTRSKRWKDDIKRPLKELSDYFTQAFCCFSCQIRQNQKSQDGVSSMMWPWRWLKRTKRSEKRLVWCFRRALVSPSVLHSLSAQDTYWTRFEPVNERKLTKQYNMFVNSNATDSIDIQDRNIFDGTVTVRIIFQEAIAFAVDPECSEPINFEIISYPKVNWLQKWLYDREARRSTVVDKARKFVEETAEQIKQVVGDNLTESKYVTPIGLATAAVAGFLIWEQIDYQRKKKHLPGPVFKVPLIGSLMDSMKPTFDKYNSKWKSGNLSCVSVFNRFIVIASNCEFSRKILNSPSFVQPAVVDSMRYILTDDNWVFMDGKQHVEYRKGLKFLFQRNALGGYLPIMDKCYQAFFDEWLSHEGKVRRYQWDFRELNMQSSLRVFLGDFMPESVAKRCSEEYFNITAALELVNFPYPLPGTKIHRAMKSRQYIYDAFIESIKDARIRIDNGGEATCLLDNWLIAMKENEKECLEKGKPAPHAFTNREIALTILTFLFASQDATSSALTWTFQLLADHPDVLKRVYDEQDRLRADDPNQPLTLELMEKSAYLRQVVKEALRLRPPVLMVPYQTHKDFPITDTYTVPANSMIIPTTYPALHDPVAYPNPESFDPDRWGPEGIAENYPKNFMVFGNGPHLCIGKEYAILHVMSTIAQATRRLEFKHYPTQDSNTIWLFATTYPKDECSMSFHPRTKFPYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUG9</accession>
    <name>A0A367JUG9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Programmed cell death protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDCD6_2</name>
        <name evidence="8" type="ORF">CU097_009620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000679">
        <property type="protein sequence ID" value="RCH93583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUG9"/>
    <dbReference type="STRING" id="86630.A0A367JUG9"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="258" mass="28802" checksum="AF584B0A0F7F575F" modified="2018-11-07" version="1">MSYQQPPPPQYGQAPPPGSGGYQQRPPPGYGGYQQQAPPPGTPAPHSAGGGGYGQGIQQQQQQQQHQQQQGYGAQAPYGAPSADQQQLWTWFKAVDTDGSGQLSADELQRALINGDWSPFNIETVRLMVNMFDSDNSGTINFNEFSGLWKYIEDWKKCFQAFDVDRSGSINETEMGNALRTFGFNVSPKFINTLIQKFDRYATVNKTGKGDVTFDNFVQACVTVKTLTDSFRQFDNDNDGWIQINYEQFLDLVVRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV62</accession>
    <name>A0A367JV62_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000651">
        <property type="protein sequence ID" value="RCH93830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV62"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="8800" checksum="BE01C487B231C372" modified="2018-11-07" version="1" fragment="single">MLKHKSSFHSYKSNNASSNTQRSIASPLNGRAVIDALKETRKNALGGLLGNKRASLGNLRQSKSSTTADQRESSTRQVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW54</accession>
    <name>A0A367JW54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000613">
        <property type="protein sequence ID" value="RCH94135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW54"/>
    <dbReference type="STRING" id="86630.A0A367JW54"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="58123" checksum="D77E9C99E72F215D" modified="2018-11-07" version="1">MPSHIGKGILATVSLLACIYHDRAVFDPKRPDIKTQPGWPLVGNLPILLQYLMYIHDFLLEGFTRLDDMTLTLSALGIPRHVGTIDPRNVEHILKTNFENYIKGPEFHGSMNDLFGNGIFNANGEEWKYQRKTASIIFNVKNFRDQFTEVFMKELQVMQTKIWDVAAHNFEVVDFHEVMYKFTLDSFIMLGFGVELNSLSAKEKVPFAVAFDEAQKNTFLRFVNPVWSVTERIAGLLMPWKTSMNEHLAVVDGFAREVTEKRRAQLAAGEIHTDLLSRFMDARNNKGNPLSNDELRDIVLNFVIAGRDTTAQALSWTFYMLMCHPRVEKKLLEEINQHITDVDNLDAPTLYEKIKSMNYAHAVFYEVLRHYPSVPLNQKYALNDDIWPDGTRIKKGDYVLWCPYVQGRSEKVWGADAKLFKPERWITPEGELRRESQGQWPAFHAGPRVCLGQHLATLEALVAITFLLKRYKFSLVPGQDIRYQVSLTLPMKYGMKVMVERRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWN3</accession>
    <name>A0A367JWN3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">APL4_2</name>
        <name evidence="13" type="ORF">CU097_013136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000582">
        <property type="protein sequence ID" value="RCH94402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWN3"/>
    <dbReference type="STRING" id="86630.A0A367JWN3"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="754"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="609"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH94402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="871" mass="95185" checksum="94673D42C4F3E085" modified="2018-11-07" version="1">MMNSINKISQEILAKLPLFRLKDLIRAVRACKTAAEERAVIQKESANIRTAFKSENPDTRHTNVAKLLYIHMLGYPAHFGQMECLKLVASPKYADKRLGYLGIMLLIDEKTEVLTLVTNSLKNDLNHSNMFVVGLALCTMGNISSSEMARDLCSEVEKLMGSSNTYIRKKAALCALRIISRVPELHENFLSKAKSLLNDRSHGVLITGITLVTEICQQNPEIIPTFRKAVPLLVRHLKNLTSAGFSPEHDVTGVTDPFLQIKILRLLRILAKGDREASEAMNDILAQVATNTENTKNVGNSILYETVLTIMNIESEAGLRVLAINILGKFLSNRDNNIRYVALETLNKTVGIETQAVQRHRNIILDCLRDGDISIRRRALELSFALINEGNVRVLTRELLAFLEVADTEFKQGMTTKIALAADRFAPNKRWHIDTMLRMLKLAGNYVREEVLAGFISLIASSSDLQQYTVQKLYAALKQDISQEGLVLAGVWVIGEYGDVLVSSGAFEEEEGVVIEVSDSLVIGLLQSILLGPYANQVTREYVTTALMKLSSRLSDASAQSKIKELLNQYTVSMEAEIQQRAVEYTNLFSYDSIRPAILERMPVPEPRTIIANNSTSDNTHAGHTASSGKANGPSDQDLLLDLMGVGTSGGGDIGGGDSSDIMAQSPTAAMSPQQPKTSNADLLADLFGGSSSVAPTTTTTTTSTTSSSMNNDLMNLLGDSQAQASKPAQPPVDPLEALGQSFSITTSSSPANDSAKGYEAYSKNGLTIRLVPSKDRTNPAIINIQALFINNGQATISNLQFQAAVPKSQRLQMNTATSNMVQPNGTEKQLMRVNNPQQTTVKLRLRISYDVAGERIDDIAQYGPFPEGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXT7</accession>
    <name>A0A367JXT7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proteinral transcription repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUP1_5</name>
        <name evidence="12" type="ORF">CU097_013760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000541">
        <property type="protein sequence ID" value="RCH94774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXT7"/>
    <dbReference type="STRING" id="86630.A0A367JXT7"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="487"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="585"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="626" mass="68904" checksum="E73DFF061EC54C11" modified="2018-11-07" version="1">MSVYNHRPMVPTPQSRIVEMLDSIRNEFDQLAQELYVCKTQRDDFEHKMNQQISEMNNFQQSLLELERTQQNQKKQYEEEIARLRQQIESRMSSGPSGMPLHPLPQQQQQLPHQPPPPPPNIGPGSNYFGGIMNAHTNQGPPGLVAPSQIPERSPSQHSQQSPHYSSQAPPPPPSSYLNGQQTYSPNRGIPTPPTSGHPQRPDWGNYSYRPGSSVPPAAVPPESVGSKRKSNSSSSSAPSAQQQQQQPPPMMARTAPNKISSPSTTGSGNLADVDPDNVPANMKVEGQDWFALFNPKTPRQLKVDLVHTMDHTSVVCCVKFSADGRLLAAGCNRATFIYDVATSQRVAVLQDETIKTEGDLYIRSVCFSPDGNYLATGAEDMQIRVWDIANKRIRNVLVGHQQDIYSLDFSRDGRLIASGSGDCTARIWSMADGKCLQVLRISDHDQKDPGVTSVAFSPDGRIIAAASLDKMIRIWDTQSGILLERLEGHKDSVYSVAFMPDGKMLVSGSLDKTLKLWQLGTNEGRGMGIERDRGKGPCKVTFTGHKDFVLSVGCTPDGRWVVSGSKDRGVQFWDPRTGQTQFMLQGHKNSVISVAISPSGKPLFATGSGDNRARIWSYDSIGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYI9</accession>
    <name>A0A367JYI9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar transporter chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VTC4_15</name>
        <name evidence="9" type="ORF">CU097_013906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000520">
        <property type="protein sequence ID" value="RCH94959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYI9"/>
    <dbReference type="STRING" id="86630.A0A367JYI9"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="709" mass="82859" checksum="1B46F454347EB38A" modified="2018-11-07" version="1">MKYGQELQQNIFAPWKLSYVAYDGLKHELKNRQLDHGWTAKDEEEFIEMLDNELSKVYDFVNAKLSEIDARILYCERTIQTLQKNPAMASDANYSIMDEALTEILFDVNDLSRFTRINFVAFQKILKKHDKWTGLQLKQAFVEKLREKPLDKQRFDVAIIYISALHDICRNRGKKSIDDTAFEDQNEFERATAKYWIHPDNITEVKAIIMLHLPVYIYNKQKKWEPVDSAISSVYFDNPNFDLYTTRLQRDEGSEAIRFRWYGTNDKSNIYIERKTHHASWLDGASVKDRFRLKESQVNPFVQGTLTANEIAHSFIQANTDKSTVDHVHFVASGIQRSFRERQLEPMLRVYYNRTAFQLPDDQRLRISLDTNLTFIREDHLDGIRRRQPSYHWRRNDVGIDYPFHNVKQDDCLLFPYAILETKLQTHLGQQPPAWLTSLVESHLVHEVPRFSKYLHGACHFYRDRLALLPWWLSELNVDIRKPRAENIGLTRSRSFKPLIDGKYRRAMIEEQEKANKEAVVNKQAERTSDRSHKSSETQVNLQTFVQETSKQLQGLPPVPPAKQEKRSQASSSSQSTSILHKLFAKGNHDLELGTKVDETKKPKMKVRVEPKVFFANERTFISWLQFCALLLTVALNLLNFGDMVSRIVGGIFIGLAAGIAIYALYRFEKRAWMINHRIDGRYDDLWGPALLCLLLVIALIVNFYLRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYT7</accession>
    <name>A0A367JYT7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000502">
        <property type="protein sequence ID" value="RCH95090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYT7"/>
    <dbReference type="OrthoDB" id="2439595at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="339" mass="39434" checksum="23691B69580C2BB7" modified="2018-11-07" version="1">MVQQSDAETESLTLTEDIVSKQVVKDDSESDKELILFSLNESLLMHKEMVERVQNEKDDVEDDYEQERREREAKINEAKRVLEEKQREQGQKRDILETQAEQLKRELASRETEYRRMESKFQSHMRSTRASDDDVSTIQRDLGSLLQDISDLCEKVPSDFDHQSVSKEEDVETRWLVEKWVVQVMIDDILNKPIQPGVVINNAFGRIFEWVKKRNTSWAVRMRQQITTFIVRQSNDDIEQAKKEIVEKIMTVLHFAAQSDIIDLVDRAVRLNLALKCQEALVEIMPIQEGGSFDSQIMNSVTEEEGCINLVIVPPFMVKEADHRFILLIPAKVHCVPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ34</accession>
    <name>A0A367JZ34_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000489">
        <property type="protein sequence ID" value="RCH95224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ34"/>
    <dbReference type="STRING" id="86630.A0A367JZ34"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="30814" checksum="4B0E47DBEB4CE6D0" modified="2018-11-07" version="1">MPTQLLPNQINIPKFKHLIIYTGNIMRTTTCVLKSWNIKSSSELLYAISDTLSTSLSSSNMPSFHYSPQSNTLEIPDIRQTSRIHPDDRDSVEVTAKLFYLKHDDQSLISYIDASIHHLEQLLGVASIDTFVVSFADNESCVEKTWKDLEAYHHDGRIRKLGVSDFDTARLKALYDNPSLTVKPSLNQVNIENCCSNQKELIELGKQYGIEMTFNVDTADILTTESLSDISSKHGVTQEGTTIKPCWVMKYHVFTKRTSVVMDKGYIIAGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZA7</accession>
    <name>A0A367JZA7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MBTPS2</name>
        <name evidence="8" type="ORF">CU097_008817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000487">
        <property type="protein sequence ID" value="RCH95237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZA7"/>
    <dbReference type="STRING" id="86630.A0A367JZA7"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="7">
        <location>
            <begin position="164"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="545" mass="60958" checksum="E717375826542A7B" modified="2018-11-07" version="1">MELISVIWQFLLLWIFIYIFVFLIQFFTTKNPGPRRTAPHSVLPTFSISSSNEVERDQWSIKLFQVKYTTHRLNSFFQRLTQLAPWFWKAWFHIGALAASVTMVVGMVVIVYAGLKILSSLTRIISVDQSQHVKRELVEPNNGDEQVFLPMIPGVTLPMSHIGYYLLALTVCGLFHEAGHAMASFAEGVPIQSSGMFVMYLYPGAFVNIPDQQLQALAPFRQLKIICAGVWHNLVLYLFASLSLAGGLKLLLILIGWQSLEGQGGVSVVHIRTNSPLATHLPPATLIYQLDDTALTHNIEDWNTFLFKEDGRHTLEQGFCVSKTHENYGDKCCDIDDTNPFGRSPNATISCFQSIETALDKQCLSTLPILASKDIPRCKEASDCHGPEMSCVIPYTPSAAGQVVRIYAQIPSWVESEEADRRRIFIFEGELVDIWESVKVSILSPQFWILPVSLPHILELILRYISSFTIALALLNILPAFKLDGEFALEQLLISFMQPTDASLVTTTRTYRATKQVQDSIVKITSIVVGFVIVGSLVMGLLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K016</accession>
    <name>A0A367K016_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000451">
        <property type="protein sequence ID" value="RCH95582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K016"/>
    <dbReference type="STRING" id="86630.A0A367K016"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="240" mass="27381" checksum="225A24691393C2AE" modified="2018-11-07" version="1">MSKKRHSGADDDKEKTVAKKQKRPCGLTMLPYEIISTIFIQSSNPSLPIVCKALYQQLYYCPDTLKIAFLMHRTKNDPEKALEEASRFRFFSYALMERLDKMTQRTVMFCDKKIPSRLFLAEPTETLQERDQLILALLERGASPNRPKGYPIIKSALLGRLDQVKLLVSFGADPTAQNNMALRACAGRNNRQMVDYFLDELKVKPDSETLKVCVQKNLWDMFQLLVDHGAIPDMSTIAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K096</accession>
    <name>A0A367K096_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_014104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000453">
        <property type="protein sequence ID" value="RCH95567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K096"/>
    <dbReference type="STRING" id="86630.A0A367K096"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016952470" description="rhizopuspepsin" evidence="13">
        <location>
            <begin position="22"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="85"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH95567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="393" mass="41434" checksum="FE1DFE096415256F" modified="2018-11-07" version="1">MKFTLISSCIAIAALAVAVDAAPGEKKISIPLAKNPNYKPSAKNAIQKAIAKYNKHKINTSTGGIVPDAGVGTVPMTDYGNDIEYYGQVTIGTPGKKFNLDFDTGSSDLWIASTLCTNCGSRQTKYDPNQSSTYQADGRTWSISYGDGSSASGILAKDNVNLGGLLIKGQTIELAKREAASFASGPNDGLLGLGFDTITTVRGVKTPMDNLISQGLISRPIFGVYLGKAKNGGGGEYIFGGYDSTKFKGSLTTVPIDNSRGWWGITVDRATVGTSTVASSFDGILDTGTTLLILPNNIAASVARAYGAYDNGDGTYTISCDTSRFKPLVFSINGASFQVSPDSLVFEEYQGQCIAGFGYGDFDFAIIGDTFLKNNYVVFNQGVPEVQIAPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0X7</accession>
    <name>A0A367K0X7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COBW domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CBWD1</name>
        <name evidence="10" type="ORF">CU097_003185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000422">
        <property type="protein sequence ID" value="RCH95892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0X7"/>
    <dbReference type="STRING" id="86630.A0A367K0X7"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="387" mass="43913" checksum="1956003754CA01E0" modified="2018-11-07" version="1">MSDDFEDIPELVPADNIEISNEPIEQQSTTNTKIPVTIVTGFLGSGKTTLLNYILTEKHDKKIAVILNEFGDSSDIEKSLSVNQDGNLYEEWLELRNGCLCCSTKDVGVKAIENLMEKKGKFDYILLETSGLADPGPIASMFWLDDGLGSEIYLDGIVTLVDAKHIKDYMKEEKKDLMMNEALKQVAIADRIVINKKDLVTDDQLRQLQEDLSSINSVADMMVTERSRIPLDYILDIKAYDVKNVDALVYQTNKIDEHAKTHAHEISHEVQTVCIQFDQQLDKLEPLEYWIQDLLWEKKIQGIESDPVTVLRLKGIIYPPKDKTLSNTKKRLVIQGVQALYDIQEGYSEVEEETNTSSKIVLIGKNLQKDRLSRSLDNVLKIKHNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1A2</accession>
    <name>A0A367K1A2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRM8_2</name>
        <name evidence="11" type="synonym">TRM8</name>
        <name evidence="12" type="ORF">CU097_010281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000413">
        <property type="protein sequence ID" value="RCH95984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1A2"/>
    <dbReference type="STRING" id="86630.A0A367K1A2"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH95984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="28941" checksum="4360986774EF3CD3" modified="2018-11-07" version="1">MSETEAKLPRKRFYRQRAHANPFSDHQLEYPSEPSLMDWTRHYPEFYPPKEGQVQKKVEFADIGCGYGGLLIALAPLFPDTLMLGMEIRTKVEDYVYERIKALRVQKPGQYQNVSIMRMNAMKFLPNFFEKAQLSKMFFLFPDPHFKQRKHKARIISPTLLAEYAYALRVGGILYTITDVKDLHLWMVKHLDEHPLFERLTDEECENDPCVPHVRTATEEGKKVERNQGDKFLACYRRIEDPYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1K4</accession>
    <name>A0A367K1K4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000400">
        <property type="protein sequence ID" value="RCH96122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1K4"/>
    <dbReference type="STRING" id="86630.A0A367K1K4"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="158"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="301"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="450"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="600"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="819" mass="90828" checksum="69974153A8791EAC" modified="2018-11-07" version="1">MIKKILFILIYVYITLCAAGLFAEKKSIFDTIVKDERFSKLTGEIEKHNLTTVFKSIKAGTVFAPINEAFDHKEVTSPEQILYHVIPVAIKSGELWDGRLLKTEAYYKKITQLLEISKDDDTIVIGTGVQLNTAKVVQADMDAANGIIHAVDHILLLPDNLYETLSLEQSVENFYDLADRAHIDHDLRFGEGYTVFATKDSVFGDELNDIEKDYLYSRQGRHDLARLLYHQVSPKIFYSTDLKEGKSKIKTLEGSEDLDILVQKGTITVNGVKVVKQNLLAANGVIHILEKPILPKNKEFLKLDSRKILQALGSSRFINLLEDNDLGAYLDSDNPLTILAPPNKALDEGSVPSNKIKSWLQYHIIRGRFLPSDLADGQLLKTESHDGLGSSFHQRIRVTLSEEDPTLYGKDSFYVSKQSIQFDKANVLRDPIESGKNIVIYPIARSLFLPRDTLSRLPVNLELSTFVASIYASGADEVIGNSEGITLFAPNNEAFGRLGLVTKHLLQPDAKEKMQQVVKFHTVRDVLYENSTTKGEHQKETLASGDKLTLNKTDDGFFIRGSGAIDGSDRSVIGKVIKKDILTSNGVIHTVDRVQLPESLEISNRDLLSAEGTQNLLGLVEHSNLSRAILEGIAGDKPYTILAPTDRAFAKINLGHLKGDPEKLVKFAKLHIIPSQLPPVDAGEIKKRWWPWDDNNKNEKPSDIGYTGTDYPSLLSDDVVLTISKNVGGGYSIKVKGSSQDSAEIIDIGRSSAGGGVLEIDRVLVPPEEEQQQTHGLPWWAIALIVLGSLLGLALLALAGYYGWRWYQDRRSGQISLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1K8</accession>
    <name>A0A367K1K8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GUP1_1</name>
        <name evidence="8" type="ORF">CU097_012760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000408">
        <property type="protein sequence ID" value="RCH96035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1K8"/>
    <dbReference type="STRING" id="86630.A0A367K1K8"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH96035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="549" mass="64607" checksum="807383C20847A7C7" modified="2018-11-07" version="1">MGEEHRQGSLRNNIDEKDKIKQPKGNPSRWHTKEFYFYYVCFCIVVPYMFKVTFNLSQSNHPNYPLYAPLLSEGWILGRQVDNSDAQYAQFRDNIPKLIPLVIVHLFFSHLNRRLLHFSSIRFTLLLSLLCVILLHGANVIKMISIISTSFLIGRFCKGTTWNPFLTWTFNLGILFLNEYYNGYRFKAVLGPSYEWLDQFEGVQARWHILFKFAMLRLISFNMDYYWACRSAENKESVDRGEAITDKERIQLPWNVDTDYSYLNLLSYVLYTPLLLCGPIITYNDFLSQFKVPSKNIDKRYVLMYAIRLVIVIFVMELTLHFLYVVAISKAKAWNGDSPLELSMIGYFNLVIIWMKLLIPWRFFRLWSLADGIWVEENMVRCMSNNFSAQRFWKSWHRTYNRWTIRYIYIPLGGSKYIAYNMWLVFTFVALWHDIELKLLAWGWLISLFLLPEIIASKLFSEKKYGDKPYYRFVCGLGAVGNILMMMIANLVGFCVGLDGVTEMLTKIFGTAHGLSFLLVVSACLFIAVQIMFEIRESEKRRGDPKWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K256</accession>
    <name>A0A367K256_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_011212</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01000378">
        <property type="protein sequence ID" value="RCH96332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K256"/>
    <dbReference type="STRING" id="86630.A0A367K256"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="487"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH96332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="754" mass="85271" checksum="E91347228EDACA5A" modified="2018-11-07" version="1">MGSSKKQSTLSNFFNGGNTQSKNSTGSKSVEDKVDQDAGSKRKKIIISDSEESESEEAMTKKIRAEDVSKTRTESGDVVMTEADDSQDVDKEIEEAVAEEKEEKQEQKETKAVIQILATTGTIKKADINWEKEAPIPYAVLCKTFEKCENTTKRLEITEYLVSLFSKVIQLRPDGLLEILYMCINKLCPDYEGLELGIGESLLIKAIAESTGRSAKQIKAEYAKIGDLGTIAKESKGSQRTLFKPKALTVSHVFRVLKEVAKISGHSAQSKKVEKIKGLLVACQENEAKYIIRQLEGKLRIGLAEQTVLSALAQAVMLHKLSSSKVSTTKKEELLVSAVDTVKYVYNQLPCYDDIVPALLKYPVEELLDHCTMHPGVPLKPMLAHPTKSLTEVLDRFEGQTFTCEFKYDGERAQIHKLANGEIRVYSRNSENMSVRYPDIMNAIEKWVKPTTETFILDCEAVAWDKESQKILPFQILSTRKRKDVKEEEIKVRVAVFAFDCLYLNGKSLLRDPLEVRREKLRDAFQETENEFYFAKHMDSNNIEDIQTFLDVSITSNCEGLMVKSFSGPEATYEPSKRSRNWLKVKKDYLSGVGDSMDLVVIGAYYGRGKRTSVYGAFLLACYDPETEEYQTICKLGTGFSEENLQLFYDTLKDHVIEEPRRFYTLGDSPPKPDIWFEPVQVWEVKCADLSISPTYMAGVGKVDETKGISLRFPRFIRVRDDKEPEDATTSEQISDFYFSQQSQQGNKAESMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K258</accession>
    <name>A0A367K258_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER membrane protein complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EMC8_2</name>
        <name evidence="3" type="ORF">CU097_009096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000387">
        <property type="protein sequence ID" value="RCH96250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K258"/>
    <dbReference type="STRING" id="86630.A0A367K258"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="184" mass="20796" checksum="350C593160A5609E" modified="2018-11-07" version="1">MTSIQLDVSAHAIPLLHAAKYPAYNVCGVLLGKANGSNLHITKAIPFFHHWITLSPMLEVALRQTEIYAHDHKLTIIGWYHANEDKDDTRLSDGTKHVAETIRKQCGHCVVFLINNKTFSQPDEAAFIPHVYTDNQWKVTNQLTIQEAASAKSQELIASSKYKDLHDFDEALEDASLDWLNEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K356</accession>
    <name>A0A367K356_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000352">
        <property type="protein sequence ID" value="RCH96618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K356"/>
    <dbReference type="STRING" id="86630.A0A367K356"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH96618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="500" mass="57549" checksum="43F6A6EC89406C5A" modified="2018-11-07" version="1">MQIIRFSPRQDIRCKSDTFAKTAHEMMSSVLDKADFNYVQGLIILALYQLSHFNGYKAWLYSTMAVRMVCELGLYKEKLFDESPGTIISVGQWMTYEYERRAFWMTSIMDTYGGACTGTPMSLHIEDYNLLLPTDLNIIETNDDFYQETLDGSRLIHYHVIRDPITQKAENIQVWPLDPRLPENQAKREQIGVESFISKANAILGMVVRTINRQLHSQDTLCYYRQGSDYYRHDKTLDAWPNGLPFNLRDIPANAERFKGMSSIKLTQYFVMHLIHYATVILLNRPALVMINSIKKETDQGLIEVVYQSAGKCIEAANRVSLLLKTIRCKTDLLPCYIGYLIYVTGTIIVSDRSFVGGRIDNSNIEDYLYYLNECKTYWGITERFYFMIYNLHLLQQVAFNSSQKEKQVPFPSSSVETTLSATTPLFDPATTSHTSTENESQHEEEGQTNDLAKYTTPAFDDRQLDYDNLGGFFLPLSHPLGTMYTNDGSFDLWLQNQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K379</accession>
    <name>A0A367K379_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_006411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000348">
        <property type="protein sequence ID" value="RCH96663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K379"/>
    <dbReference type="STRING" id="86630.A0A367K379"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.340.10:FF:000007">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11 13" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="362"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH96663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="599" mass="64976" checksum="F38CCF8697CC5CC8" modified="2018-11-07" version="1">MTVEILSKDKYSVEKQLIVPDEIRDIQKTIETWTDQYNLNLILLTGGTGFAERDRTPEAIKPLLTRETPGITHLLLSSSLFITPFAALSRPVTGIRNKSMIITLPGSPKACKENMEAVLKVLPHALDLLSNQHNESVKQTHAQMQGHRCIHSEREENLTGQSIPLDTPVSRRARSSPYPLISVDKAQKLVLEHSTALNAVLMPVSQFLASGYVLAEDVKSIEPVPGYRASVVDGYAVYVEDGPGVYPVESIALAETQEANTTLSRGKIARVATGGMVPDGANAVIMIEDTKLVKASTDGKQELEIEILVGASKGDNIREIGSDCGVGQVVGVKGQRIGASEVALLASVGIRHVRVYRKPLVGVLSSGNEVLDHMPTDRLKPGQIRDTNRLSLLAAIRNAGFETMDLGIVSDKVQDIEECLDEALSKVDVIVTTGGVSMGEADLMKPILEQKLNATIHFGRVLMKPGKPATFATVPCGKKSKLIFALPGNPVSATVTFYLFVLPALRKMAGWSNPENVVISVELENDINLDTRPEFHRVHVRASMNGLVAKSTGSQLSSRMLSMKEANGLLKLPMKSPEQSRLQKGTKVQCMLIGQLDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3D4</accession>
    <name>A0A367K3D4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000344">
        <property type="protein sequence ID" value="RCH96698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3D4"/>
    <dbReference type="STRING" id="86630.A0A367K3D4"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4 6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="9">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="180"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35777" checksum="F7BF64460BD6A586" modified="2018-11-07" version="1">MSTTTSLFQILPSQPTFNNTQQQQQQQQQQQNTTQNNEQKGQLFNQPPSLFNLGQSQSFAVDKQQQQQQQPYVPKKELIHTAPIFFVSSQKEEKKKQTMEPVLTRSGSISLNYGDRRLSNILSDSKTSQTGSNVGKKRILLEVPDPSRGLFGDGNVYKRNKVDDLKKKTMKEAIPSTSSSTIRVYGFPTHLFNDLKQYFEKYGNVTECKRSLADWVLVTFENNAAATQALKENNTEIYGYPVRIIPHIEPSTTIRQGVITLEESEGIFKQEKPKELGHGKEGITAFDGRTVADGEYLMKPVDNSITAKLKEVFFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4C1</accession>
    <name>A0A367K4C1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000316">
        <property type="protein sequence ID" value="RCH97010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4C1"/>
    <dbReference type="STRING" id="86630.A0A367K4C1"/>
    <dbReference type="OrthoDB" id="2285422at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="70882" checksum="3A35818FDE54A844" modified="2018-11-07" version="1">MTFDTIDTPHHYYQIPLDDIWSKLNVSYTEAGINVETNVTSASDLHSLIDAFGKLCDTNPPDPAYSPTTVSGITPLYRNKSHQSKPVNYFICTDKLGKRITPIRQNNGQLQDIADACIHTYFECWIRFTPILSREEFMQWYMSHPDPTSTLIVNAICLFVFRHMVTHHCPPELEHYITNQDTIQEQEEYFFEQAREYLAQTFDHPDRFTIIALSYMMSRAEPSRRHQYAGMAVSALHQLDIYPRLVDDDDMSFEKEKDTRLWWFVWAWDFYMSSSGAPKNTPQPRVPGKEIDLPRVMEQDIDNGELGMLVFIHCLQIWKIQSRVVTTFYEQAADMTLEQLHAYDKQLLEVYQQLPCYLKGQSKNHDVLLASIRVHLEYNATRIILHKLFIPDQNDPRPSQASLESLNVCLKAALQQIPNLSTELPKARCAFDRDEFWRACEVISLAMDIHRTCASPKDRALITKDVDLQEFESGLTRGLYILKSTKEYQVGGRGWIQVVDWLEVQIRRHQLYSRSKPIMDPSCSLGNLKREVKQLPSFDHQYSMHPFQATKKSLVSTSSISFVPFHPTSSSPPRSRRNSSDQRGKVQSKFRYFSPKKMNKFMFIDDNPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K573</accession>
    <name>A0A367K573_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000286">
        <property type="protein sequence ID" value="RCH97328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K573"/>
    <dbReference type="STRING" id="86630.A0A367K573"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="22222" checksum="23EA095089F451A1" modified="2018-11-07" version="1">MTYFETLKRSYTDVDTSKGVDTEQFLEATEGLVKLFDLLGSAAFSVVQNDMNGNIKKIRDRYLSNPTANNTLEELMKNEAPEKKRVATEGLLWLTRGLDFTAQALRRSLSDPAEELNTSFTKAYEQTLKKYHSIIVRPVFALAMKACPYRKDFYEKIGVVNDAAMAQMKAWLEALENIISIIQNVFKANPAYIKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5V4</accession>
    <name>A0A367K5V4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000267">
        <property type="protein sequence ID" value="RCH97557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5V4"/>
    <dbReference type="STRING" id="86630.A0A367K5V4"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="80"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="50251" checksum="91015BF5B853380A" modified="2018-11-07" version="1">MQNELSEKTPRTSYDELNGMTLTPGNQIEKLSTVHTEKYDVEQGQLETVDRVKTNVTIASIIELPDPNNAFYDSIPDGGYGWVIAACGFLINFIMFGTSAIWGVFSNAYATTVLQGKSTTMELMGVGSLMVVTLNLFAPVGPLLAPLGPKVTLGCGTILMSLGIILAGFSTEVWHLYLTMGIVFGTGSSLVYMSVVGVIPQWFSKRRGTAMGLSSAGSGFGGLALSPMVTSLVQKYGLPWAHRIIGLMAFGICAIASCLIRTRLPPGAEKQPIKSPIKLSMLKDLNFVIMLFGLVIALFGYLIPLFYIPTYSRAHGISAEQSSTIVGVACAMNAIGRLVLGYFADHIGRLNMFIIASTSSGLFCMLLWPFAKTFETMMAFAVLFGFTCGIYYALAAPITASIVGTDNIASGLAILFVASSIAGVGPPVASAIQLATPNGGYIGVQMFSGGVYILGSLICIALKVKMTGSLVSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6W6</accession>
    <name>A0A367K6W6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_012221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000241">
        <property type="protein sequence ID" value="RCH97879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6W6"/>
    <dbReference type="STRING" id="86630.A0A367K6W6"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64234" checksum="E4CB525E393FEA51" modified="2018-11-07" version="1">MTNWVEKINDRVARSVVGKYFQLEYSGHRRERKGTRFFTELRAGVTIFFAMAYIISVNASIISESGGTCICNSTAGDPTCDNDPAYLQCVYNFRLDLIIATSICAMISSVLIGIFANLPLGMAPGMGLNAYFTYTIVGYHGSGKVSYETALAAVFIEGIIFFVLSLFGVRQWFARIIPMSIKVAMGCGIGLYLCFIGLQSSAGIGLVRLDYSTLVTLGGCPSAALDEHGSCQWGHMTSATMYMGLLGLILMSLLIMFRVRGAILIGIIVIAITSWPRNSPITYFPYTEQGNMMFDYFKKVVTIHNLQNVLGRFNFDLTTKDIWIALITFLYVDILDTTGTMYSMARYGGFTDKAGDFEHSTWAFLADACAVSIGSCFGTSSCTAFVESGAGIAEGGRTGLTAITVAFGFFISIFFSPIFASFPPWSTGPALILVGSMMTSSVRNINWDYPGDAIPAFITMAVMPFTYSIAYGVIGGICAYIIINGAVYVMDKGSRGRIRPDYSQRENWWTAVLSRSFTPTWIQFLIAKIRGREFDWRQDEYEFEDDDDVASRRHPISEEAPTVVIGADNGSGIETISMNNNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7V6</accession>
    <name>A0A367K7V6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000213">
        <property type="protein sequence ID" value="RCH98236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7V6"/>
    <dbReference type="OrthoDB" id="10488385at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="16109" checksum="847B2BBD6B248B9B" modified="2018-11-07" version="1">MPLHCSYCHKPNHSRLDCPVRSALRCWTCLSNGHLRTHCPQRVTRTTASAKSKPAKKPKKSTKHSASTVPLAPKRSPPRSDSETDPVSPTRPPPLKQPRPNTATFMEVEKPPPISRSTPVSPSRDSSLDQTLKTTMPAVFAKALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8U7</accession>
    <name>A0A367K8U7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000180">
        <property type="protein sequence ID" value="RCH98653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8U7"/>
    <dbReference type="OrthoDB" id="2216467at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="9431" checksum="5D2A9FF252CCA935" modified="2018-11-07" version="1">MQEIGQLTFPRSLEELASFVNLKNIRTLLMVTETFWRLCRPLQDEEFWETKRRPTHPATYSLIDSTKDRRRFCALRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9K5</accession>
    <name>A0A367K9K5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000165">
        <property type="protein sequence ID" value="RCH98865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9K5"/>
    <dbReference type="STRING" id="86630.A0A367K9K5"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF141">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione S-transferase C-terminal" evidence="1">
        <location>
            <begin position="139"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="238" mass="28007" checksum="AA15DC46449AE93D" modified="2018-11-07" version="1">MVSYFVETLYIPKDLVILNSFRNTLQCLYFWARKPAFIILTLANQHSGRGENLKLFLIDASLEHDYIRFNRETKWTEMREGIIKDGYYAGSAPYIKMGNKIVGRTVPVMRYISAKLGNKYHGSTDKESYLLDVVSDMTNDWFESIKKLHIGNEEEKNMSYRSHYSKLAEKSLTTTTHAIKMGHISWEIRQITYPDFLVYHLLDDDQCLQRLDEYPKLKIFVKAFEERPNTKEHLTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9X1</accession>
    <name>A0A367K9X1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Low affinity vacuolar monovalent cation/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_010769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000182">
        <property type="protein sequence ID" value="RCH98631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9X1"/>
    <dbReference type="STRING" id="86630.A0A367K9X1"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="358"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="662"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH98631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="91569" checksum="57A48DF43E36A19E" modified="2018-11-07" version="1">MDPPQKIPRRRLSRTTSSKYGAISDENKRHLEENSSASQQDINGQSHSSGSQQEEDTSSDEQSPHHPLEHELTLKDIQDAMNKQHPFGLPLWKPALYKKSRSVVRKANSALHSSPSSSSELFLNPGNLLWLLLFGWWLALIIFIVSVPFIVFHDAYGMIMRELSLYLLWPFGRYVERLIDITPSIINDLEREQTEHSLLIDDNDEFETERDGLLHGHKKKKRYNWFHAVAETLKLGPAGCLYYIVFYTVIGPLLMLVSSICWMCVVTVPMAKLNYILARHLRRHPLSLRFRSNNVSVSAHHPTVILLCTYQAVGWQYYKYTYDGINIMFINLLPLVFFVIFDEYVLKEHLPDSFITSAPVIFGLSLASVIPLSYFIGMGVSSISAQSSMGLGAVINATFGSIIEIILYAAALMAGKSLLVEGSLIGSILAGVLLMPGCSMVSGAVKRKEQRFNAKSAGVTGTMLIMAIIGALSPTLFYQFFGSFELRCTGCPEDVDNHNMSLACSHCYYDQSDPMHDPVYQNNVKPFMYLCAAILPSAYIIGLLFSLHTHADMVWKNATTKHSAHDISTHQKLYPIHILRSQHSDNQQYQHQEQPSESTSTNILIPATIQKQPSSPLVTVVPPSNQSSTPIAFIHAKEPEEEEEEEAAAGHDSPNWGKGKSYTVLFGCTLLYSIIAEVLVQTVDQVMEKIAIDEKFLGLTLFALVPNITEFMNAISFALYGNIVLSMEIGSAYALQVCLLQIPAMVAFSLWYNWGKEEVKQFTFNLIFPRWDVISVIFSVFLLTYTYQEGKSNYFKGSILILSYFVLVAGFYYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAY4</accession>
    <name>A0A367KAY4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KGD2</name>
        <name evidence="15" type="ORF">CU097_007042</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000127">
        <property type="protein sequence ID" value="RCH99375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAY4"/>
    <dbReference type="STRING" id="86630.A0A367KAY4"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="68"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="149"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH99375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="49911" checksum="49BE76F1EC26A195" modified="2018-11-07" version="1">MQYSRVALRLSRVSLSKNVIATTAVRHVQRNLHVQTAASLYTVGYDRLKQNSNLQNSTIKNQIRTYADKVIKVPQMAESISEGTLKQWVKQVGDFVRQDEEVATIETDKIDVTVNSPASGTIVEVYANEEDTVAVGADFFKLELGDAPKEGAAPAKKEEPKKEEVKQEEVKQEEVKKEEPKQEAPKKEEPKPAAPAPKPAKSEAPKPASAVGEKVFGNRNETRVKMNRMRLRIAERLKQSQETAASLTTFNEIDMTNLISLRADYKDAVLKKHGVKFGFMSAFVKAAAVALQEIPAVNASIDGNEIVYHDYVDMSVAVSTPKGLVTPVLRNVEDMNYLDVERSIAELSKKARDNKITIEDMAGGTFTISNGGVFGSLMGTPIINLPQTAILGMHAIKERPVNVNGKVEIRPMMYVALTYDHRLIDGREAVTFLVRVKELVEDPRRLLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBH1</accession>
    <name>A0A367KBH1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_015439</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000118">
        <property type="protein sequence ID" value="RCH99517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBH1"/>
    <dbReference type="STRING" id="86630.A0A367KBH1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016662131" description="rhizopuspepsin" evidence="13">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="69"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH99517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="428" mass="46998" checksum="73D6A4E38AEE7B49" modified="2018-11-07" version="1">MLFLKRKQSIFFLILFHIILSQAAVIPTSSSNQYIQLDLFKRQNDHHSLTKRYVNDTSFKLYNEQRTEYLIKISVGTPPQSFMVSFDTGSSDTWIPSSKCSNQACKPSAFDSNKSSTFKPLNMSFSITYGLGSISADYAKDTMRLGNISVSDQTFGLATSVGDNIIAPTDNTITSSGILGLGFPALTANSDTALAYDPFIFSLAKQNLIPEPIFGVYLGSMDATGWAGEVLLGAVNQSKYTGELKYVPVQQNINPKTQKLDYTYWSVGIQDIKVIQNNQTASITAAGNSSESSTKNAMLDTGTTFTYLTKEMADRIIGLIAQRSPSEMSQSNGLYVVDCNLKTTEVKLELMIASTDTNQPVHWQIDIMDLIVPLSENRCGFGITYKESSLNDNLIIGDIFLRSSYLVFDMGNKRVGLASAAGMKSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCF9</accession>
    <name>A0A367KCF9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="12">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MCR1_5</name>
        <name evidence="14" type="ORF">CU097_015388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000095">
        <property type="protein sequence ID" value="RCH99858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCF9"/>
    <dbReference type="STRING" id="86630.A0A367KCF9"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH99858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="261" mass="29736" checksum="86B556E1AA40F976" modified="2018-11-07" version="1">MVFSPSEFRPFTLEKIVRINHNVSLFRFKLPKSTDVAGLPVASCVLFRSHITKDGKSEEVVRPYTPTSVEAAEGHVDFVIKDYPQGNMSRHVHSLKVGDTIDIKGPFEKYKWENKPVEYVGMVAGGTGITPMLQLLRKIFSTESPYKNTKVTLLFGNQEERDILFRDELEGYQRDYPDRFKVIHVLERAPENWSGPKGFITQDLIQQSFHHPDVEDSIIFVCGPPPLMEAISGDKNPDKSQGTLRGFLKSLGYIQDRVYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD16</accession>
    <name>A0A367KD16_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_015181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000082">
        <property type="protein sequence ID" value="RCI00078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD16"/>
    <dbReference type="STRING" id="86630.A0A367KD16"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16620" checksum="083CB64422820C3D" modified="2018-11-07" version="1">MLVSKQNRKVIYEALFKDGALVAPKDYNAPKHTELDVPNLEVIKVMQSLTSKGLVKTQFSWQWYYYTLTDEGIDYLREYLHLPQEIVPATLKKTARPASAPRRTFGGDREGRAPRGDRDNYRRKEGASGDFKPEFRGGLGRANRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD62</accession>
    <name>A0A367KD62_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ATP16</name>
        <name evidence="16" type="ORF">CU097_004717</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000079">
        <property type="protein sequence ID" value="RCI00117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD62"/>
    <dbReference type="STRING" id="86630.A0A367KD62"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="15">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI00117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="163" mass="17322" checksum="04CCD3DB2383752F" modified="2018-11-07" version="1">MNVLARSARAAIKPARLARFYASEAPASTEALRLTFVVPHKAIYKGTTVQQVNLAATSGDMGILANHVPSIEQLNPGVVEIIESAEITKKFFVSGGFATINPDSSLNINAVEAVSLDELSLERVQTALAEAQRNAANAASEKEKAIAKIEADVYEALQTALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDW7</accession>
    <name>A0A367KDW7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000063">
        <property type="protein sequence ID" value="RCI00388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDW7"/>
    <dbReference type="STRING" id="86630.A0A367KDW7"/>
    <dbReference type="OrthoDB" id="2285383at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="14833" checksum="81B0156FDD64A14E" modified="2018-11-07" version="1">MAKVELWDDSGKEAAAFAADPSFRLTNLRNLHKYIKNKKIVVEYEELKDADMQEVPTMRPKCYCESQGPEQESLIEGLDIRMVDVVNLVGTVKKQQTSYDNYSSEQRFLFIYYNQVKLYNCLRAYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEV7</accession>
    <name>A0A367KEV7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000064">
        <property type="protein sequence ID" value="RCI00372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEV7"/>
    <dbReference type="STRING" id="86630.A0A367KEV7"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="15503" checksum="F7A5DA8356382D6D" modified="2018-11-07" version="1">MALIYSLYIINKAGGLVYQKDFSNQLEKLSSNEYLVLAGTFHGVHAITSKISPIHNSTGIQMLEAENFKLYCHQTLTGTKFLLITAPQLNNVDSYMKRIYDLYSDFVMKNPFHTPEMPIRSDQFDQSLLKFINTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEY8</accession>
    <name>A0A367KEY8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000041">
        <property type="protein sequence ID" value="RCI00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEY8"/>
    <dbReference type="STRING" id="86630.A0A367KEY8"/>
    <dbReference type="OrthoDB" id="2888121at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19610">
        <property type="entry name" value="mannanase_GH134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049168">
        <property type="entry name" value="Glyco_hydro_134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21087">
        <property type="entry name" value="Glyco_hydro_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016662132" evidence="1">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="183" mass="20706" checksum="A58968FA6894226B" modified="2018-11-07" version="1">MLVKFFALFLFFTFTLVSARPGDRGHYPVPNLGKRKQEILKAGGGIWDIAIAMLESDHMITDYAYGDNKSGDAANFGIFKQNWFMLRTSTSQFKGQPASASNNGAVLNKRLAQDIKARQESQKFYGPDKWFGGHRNGESGLNNPYTQDITNYKNAINWIHDQLASNPKYLKDDTRFWVDVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGA7</accession>
    <name>A0A367KGA7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ecotropic viral integration site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EVI5</name>
        <name evidence="6" type="ORF">CU097_013423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000018">
        <property type="protein sequence ID" value="RCI01255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGA7"/>
    <dbReference type="STRING" id="86630.A0A367KGA7"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="198"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="688"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="931" mass="105990" checksum="766B1AA6DAD5B87C" modified="2018-11-07" version="1">MTTAALLAPEIKDRLQEPTVANGTSSSLLQPDFKLEKSTSTSLAERRRLPVSPEKLKLFNQITATHTPTKQLNQTLKRLEEENAKLPPQDSEEYLLARLERQNVLLNADPKSVCIESNRLQADFNTIRKLVTDATFSPTRENYEESIQAMLAKSPITSTTCLTTDQDDWDFWQAIVEDYPAAAAKLPHLLSAKLRCGGIPHRIRGLIWQSMAQSSSLNLESCYEQLLQEDSSYERVIQRDLSRTFPQLDMFKDDGGEGQLALGRLLKAYSLYDTHVGYCQGLAFLAGPLLMTMPENQAFCIFVRLMETYEMRTMFTLNMEGLHLRLHQFQTILAQVCPRLEAHLEANSIHTAMYASQWYLTLFAYTFPISLVLRIYDLVFAEGAVETITRVAIAIMKKNEETLLAMDDFEELMMYLSSRKLYQVAYNSDPEAVIQDAMSLSTVITRQKMDSISENYNKDLEQEKTRAQQLLNIRFSGWKSKKKNKRESWFNWGQPIQTTAAEESLVTEQPPSPTTPDRFSPMLHEQIEDLVMAVSELQRENTRMSEELMARRMREMDLVAERDQLLKKVSLKDTDELAKIRAEQPSPAESVDRQLGENHVDIKLQPDFVESLKSSGEFGALVAGALSSDKDNRMSETKFDEVTSELINIKLANFEMGLKYQELCQNHENVLKKLKETQEGQTALVEKIMSLQTTIESLQIDKEKLLQEQEALVAENEALIEKNTVAKKTLADLQLEKMNLENDCQQYKDRVKELEDQRREYLMPRGSFTEEVLAAHQTLFGSSSAAPPTNRRHTVHMVEQEKDKYQAKYIESDLKCRELEKLLAEAKYKLVEYEANAASTPVSSPRASLQQPKRPVSIQTKRSSLSALINKSGPTSPPYTESNYMARESIDSLRSTTSTTSQKRSSIYSRFFNTLSGEPLTEEAQAMTNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KIH0</accession>
    <name>A0A367KIH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000001">
        <property type="protein sequence ID" value="RCI01642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KIH0"/>
    <dbReference type="STRING" id="86630.A0A367KIH0"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="322" mass="37194" checksum="696AD3D9CE30C660" modified="2018-11-07" version="1">MPTTRKTAATKKTEQKPVKSEAKKSAATVNKKQATKAPAQKPVAKKQAKKVNAKQLESSDEESEEEQEIEQKPKQEEAEQENDTENDSEEEEESEEEEMTEEQEEALRKKILGDLASSDEGEDSSDDEDLIGKNEDVVALDQKQMEDSMKETKKTFEEKKDKTKKKVDTSKRGVVFLGRIPHGFYEHQMQKYFQQFGKVTRLRLSRNRKTGASRHYGFIEFQEPEVAEIVAETMNNYLLFGHLLQCKVVPSENIHEKLFKGANKRFKISNFRGKNRNRQNKKRSGEELQAQHNKLRKNEKRLRKTLKTAGIDYDFPGYTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKY3</accession>
    <name>A0A367IKY3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA 2-thiouridine(34) synthase MnmA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005259">
        <property type="protein sequence ID" value="RCH78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKY3"/>
    <dbReference type="STRING" id="86630.A0A367IKY3"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12705" checksum="53EF45B680948CE6" modified="2018-11-07" version="1" fragment="single">MLTRLLQKSYSTLNNNRVVLAMSGGVDSSVAAALLKQQGYDVQGIYMRNWDTSDERGVCTSREDWEDVQRVCEILKIDCQHVDFVKEYWNDVFEKTLDDYAHGLTPNPDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IM00</accession>
    <name>A0A367IM00_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004999">
        <property type="protein sequence ID" value="RCH78663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IM00"/>
    <dbReference type="STRING" id="86630.A0A367IM00"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="16785" checksum="44800A2681DC84E7" modified="2018-11-07" version="1" fragment="single">MSSSQRYSGRKRKQEYVPKERYDIDGTLIRNEEYSNKKSTWDFREIIRDQHKYYEAMKEAQAFVKAKKNEKEALDPIDHGRCWTEEIDDLFFSRRKRGMVSWYMPTGSPIYYEFERFYENLKESVNKDKKPATVKRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN78</accession>
    <name>A0A367IN78_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004692">
        <property type="protein sequence ID" value="RCH79119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN78"/>
    <dbReference type="STRING" id="86630.A0A367IN78"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3020" evidence="2">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="22423" checksum="A85439D5D660AF87" modified="2018-11-07" version="1" fragment="single">MLTDKDNDLRCRVNKRAHKLFGKEDNEHKRAWIEEEFRKRQQKRKEKERRKGVIDNSLGAVQNHNISHPPPTQSFMSPQQQLDINYLMMLCNSLGIPGAARALIGNATATTTTTSTNNTDTQYHPQQQQSSSSSHIENNPSSSSNNELAALPTFPNMDNTNKPEEKLAALLASTLAAAAAASNKEEGSERPATEHTEFPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQX8</accession>
    <name>A0A367IQX8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004129">
        <property type="protein sequence ID" value="RCH80046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQX8"/>
    <dbReference type="STRING" id="86630.A0A367IQX8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053135">
        <property type="entry name" value="AKR2_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312">
        <property type="entry name" value="D-THREO-ALDOSE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312:SF1">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="16613" checksum="16C62540ECCC8408" modified="2018-11-07" version="1" fragment="single">MSVLKSVIPKTGKIVSRLGFGSYRVNQEKHAQALVAAIESGINIIDTAHNFEQGASERWIGNTLEKIISDGRISREDVAIVTKSGYLTSSDTSLFSPSDYVQLNEKSYHSISPKVIEKQIETSLQRLKTNKIDIFMINAPERMLMAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISW1</accession>
    <name>A0A367ISW1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SUN-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_001175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003772">
        <property type="protein sequence ID" value="RCH80719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISW1"/>
    <dbReference type="STRING" id="86630.A0A367ISW1"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017018522" description="SUN-like protein 1" evidence="12">
        <location>
            <begin position="16"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="13">
        <location>
            <begin position="133"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="368"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH80719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="647" mass="74364" checksum="6534524471D72E1F" modified="2018-11-07" version="1" fragment="single">MLYFSLFLFCPLVFAFNYCTKDYYDGLSPICPAKASTDVSPSLFPDLMTTTRQTASSTPIKPFSSFEEWQKQVLKDSNGSATTNNNRHRSSQNEKKKTLGQTRQVVDSLDGGLSDDLGSMFENLMDTPKSTQNVYDEKQYISPIGQDKKVDNLKYLKERFNYASVDCAATVRKANKEAKGAQSILFESKDQYMLNKCSTNKFVIINLCEQIRVDTIVMANFEFFSSTFKDFKVYASSKYPTDDWRLLGQWRAKNTRDLQVFRVPESPWTNYIKIEFLTHYGHEYYCPLSLVRVHGMSMMELYTTIESNDEDDEESPMIEPEHLWPAEIREQIIQPQFDIGNTSESFPIKIDEDDAKPEPVEAHEPIIPEIPGHETHDQEASEQVSETPKEEQIESRQTSPESDSRGTCAQETAILTLPMDKPLMTTVAFISSSESVTVSSSTQSITMNTPTPDPVHSSNTTEDHNRPIVTQHKTHHTKEAITQESIYKTIMKRLSVLEHNMTLSQRFLDDQNKVLNDVFLEMEKRHQEQLIVLIGHLNETASQKIDNMASLFIYFDCKKRYEQWYANMKDQTESDMREMTTKINLLADQLSFEKKLSLIQLTILITLFVYMALSKGTLSTLSPIIAAQLEERRKRKTRKHPELFIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUE3</accession>
    <name>A0A367IUE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003486">
        <property type="protein sequence ID" value="RCH81325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUE3"/>
    <dbReference type="STRING" id="86630.A0A367IUE3"/>
    <dbReference type="OrthoDB" id="2224506at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="19282" checksum="6C24F6EE54580598" modified="2018-11-07" version="1" fragment="single">MSSTVKFYHYLPSDEFAYDEELEYQPKQDGAAITSLYQMGSIPNNDVVMEEVDLEATPLPNMIWIPIKYRPRDVAQFISLLQNKNYKVAKAAKEASIGLKAAYKFNDQWRKHEGIILPGYKPVSEIKRKGNNIKLTEEHSQYLNEFVEKYPTCIVKDATEPLCETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVE5</accession>
    <name>A0A367IVE5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003370">
        <property type="protein sequence ID" value="RCH81589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVE5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="64" mass="6884" checksum="59090F2E3D638EDF" modified="2018-11-07" version="1">MSEQIVPHAISGNDATVPISSYYDPVSADRSRGRALLESFGQSGYHTCTAAKGKCSQRPGDWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVM3</accession>
    <name>A0A367IVM3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003319">
        <property type="protein sequence ID" value="RCH81702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVM3"/>
    <dbReference type="OrthoDB" id="2288984at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="74" mass="8472" checksum="CD7E64FBAF92E4EB" modified="2018-11-07" version="1" fragment="single">VNDGNPVLRPGQIQFFFCHVFGDALHTLAFIKWYKPTPLAFQTHRLYGMDTWSNDFEGASSNCILPVHRIHSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ43</accession>
    <name>A0A367IZ43_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002834">
        <property type="protein sequence ID" value="RCH82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ43"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="18373" checksum="4A178488E5C49685" modified="2018-11-07" version="1" fragment="single">RAIAWQMGMRTILWDQDSNDWNLAGGKIRAKAIDGYFQTWINARKNGTDDEHGHITLQHENSNATIHLSEKWLPKVQKSFRVMPIHQCINDPHPYWEKNWIYPTLDEPNPPRSVMSDKESNVHGANVIGNANDATSALLSSLKTSLYTTMLSSFLLFLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZV5</accession>
    <name>A0A367IZV5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-Gal betaGal beta 1,3-galactosyltransferase, polypeptide 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B3GALT6_1</name>
        <name evidence="11" type="ORF">CU097_002364</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002816">
        <property type="protein sequence ID" value="RCH82991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZV5"/>
    <dbReference type="STRING" id="86630.A0A367IZV5"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="61238" checksum="E178E3B14D634C3C" modified="2018-11-07" version="1">MAKSNKLKKPPRFYFWRKTLSLSDLNLPRRSKITVDALRTLSLFPSVLGWAYNWQQALQVPLRDAGGAVILQSSQLDYVVASFWCALAGYWNWILTTSMMRRWIYHYEIENAIVRLITFIVITWSISAFVGSRNGPDQPIRTWMINCFILLITDVIRLSIVSDPKYHGKNANVGDPNLFLKLTITKVFIIPMSVATCLSVIAVLIQIDQLHYSTSQLMAGPVLLDANLTQASHGSVLVLIMSCWTYTCFERRQVLRKTTLKLLEPYQHVDYRFVLGQPPSAQAQMLVGPDIIQESDIHKDMILVQSSDIETDKSRKVFEAFKWAKELNHEYIVKVDDDIFVRWDTIIEELKAMDPKPYYWKGLTYRNIPIRTLSNYKTLKTDYALPVIPAYTHGMLYIFSKDILELILNPSSLRRFVHGDGENFAIWLFGFNISPNHDRRIHDAYDVCENDFIGKRMERTTDMLVMYSNLVSGRLPCTGFDLNGCALCYSCLNKRPSWRTINFACDPDKGIILREMVGFSQIAGQLDRTSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZY7</accession>
    <name>A0A367IZY7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CHT1_5</name>
        <name evidence="11" type="ORF">CU097_006333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002724">
        <property type="protein sequence ID" value="RCH83254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZY7"/>
    <dbReference type="STRING" id="86630.A0A367IZY7"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH83254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="407" mass="44805" checksum="3CC961D94DACB895" modified="2018-11-07" version="1" fragment="single">GQNSASVAGNDPDHTLWQKPLAEYCDREELDMMVISFLHKFGEGRLTSFDIANSGKDCAGFFPGTELLNCPQMENDIKYCQEKGKKILLSLGGATPEYGLDSIESGQSFADELWNTFGAGQNEHRPFGNAVVDGFDLDIENGAKAGYPAFINRMREHYSKDASKQYFIAGAPQCPYPDYYLGEALDNAWFDFVMIQFYNNYCNVINGPQFNYNTWDEWARTKSINKDVRLFVGIPGSPSAAGRGYVPYEQLVSTIKPLQQLMTFGGIMVWDVSQAYGNTMDVLPSYAHGIAQLIHSSNNTLETVLAPESTTIATMNTVSQSPATTAVVMTTTVSPVETTSPETNTVDMTTSRPNEIRHGESCLENGALKCSGESSYGQCTNGYWVVRNCPVVTVCKENNNSIFCGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J101</accession>
    <name>A0A367J101_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002606">
        <property type="protein sequence ID" value="RCH83614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J101"/>
    <dbReference type="STRING" id="86630.A0A367J101"/>
    <dbReference type="OrthoDB" id="2283025at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="468" mass="53591" checksum="66963BEA6DED4BD4" modified="2018-11-07" version="1">MDSSSGTNERWRTKKQSITQRHVDKELQRIKSLAVVSVLNKAFEDPNATPTEQQQPQPKKLTDSRSRSTSSGSQDKESTFFNPTVRRKSDFNATKLPPHMIPTTDTIPSSEKRQLAELQDKYEDTLKELSTVKSRSEQQSQLLTMQGALIEQLSEQIEYLTEENQTLRAQQSVNDVIDIRDVQREIIDLRQILEELNTAKDEYEMMVVSVGDRLEESEAKLEDMEQSAKELKRQCQSQSMYIEAKVETLMNQLKEKDEVVNKMYEQKIKQMYPSRKSESVISASSMASDKQDKQDEEEEYTDRTSARSSVTSKSSQQRRRSHIARWKGAALPPASPPPSAPLPPIPVESPNTSFRPRSAVTESTSSSSRLPVYKHMSVDAVGGPQSFSSLHELDKEISDAMYYKEFTDQLQARLSVSKEIDDLQNAVWKPSDYDEIQRKIESKNWLDQDVHPKDQSAFWKGMKKKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1B9</accession>
    <name>A0A367J1B9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ADP/ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_006146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002637">
        <property type="protein sequence ID" value="RCH83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1B9"/>
    <dbReference type="STRING" id="86630.A0A367J1B9"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="116"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="208"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35997" checksum="9EF21B768AB16C47" modified="2018-11-07" version="1">MEEKKIVSFEEYKLPPLGHAVSGAVGSTIANLFIYPLDISTTRLQLKQDKEENEGILSTIKSIYQKEGGIKGLYAGLGSDTLATVLSSFIYFYCYTALRNVQEKLNTRMGKPTAQLNTAQELFLGAEAALISRFFTTPVSNVTTRLQTNGGNGGFRSTAMSVFDQKGITGFWTGYRASMVLVSNPSITYFVFEKLKAFYLQTNKKSSLSSFEVFLFSALSKSIATMITYPFIFLRTRMVSGKNDREKSKDERVKTKGMVETLKEVVEKDGMIGLYKGMKAQLIKGFFNQGIMYMIKDYVATYLTLVFYHSYKLKMKAKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1Z5</accession>
    <name>A0A367J1Z5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002504">
        <property type="protein sequence ID" value="RCH83952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1Z5"/>
    <dbReference type="STRING" id="86630.A0A367J1Z5"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="130"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="572" mass="66349" checksum="4BFCF219A73AF495" modified="2018-11-07" version="1">MLEKRLEKMEQLVTCPQEEEKRDQLPSKEIIDHIFDLYIELFAIYPLCIDIKRMKESIKNNTYDRFLLYSLLSTVARFSPRQDIRRKSDIFAETAHEMMSSVLDKVDFNYVQGLIILSLYQLSHFNGYKAWLYSTIVVRMVCELGLYKEKLFDESPGTIISVEQWMTYEYERRAFWMTSMMDTYGGACTGTPMSLYIEDYNLLLPTDLSIIETNDDFYQETFDGSRLIHYHVIRDPFTQMAENIQVWPLDPRLPENQAKREQIGVESFISKANAILGMIVRTINRQLHSQDTLCYYRQGSDYYKHDKTLDAWPNDLPFNLRDTPANAEKLKGMSPIKLTQYFVMHLIHYATIILLNRPALVMINSIKKETDQGLIKAVHQSAGKCIEAANRVSLLLKTIRCKADLLPCYIGYLIYVTGTVIVSDRSFIGGQIDNSNIEDYLYYLNECKTYWGITERFYFMIYNLHLLQQVAFNSSQKEKQVPFPSSSVETTLSGTTPLFDPATTSHTSTESESQHEEEGQVNDLAKYTTPTFDDRQLDYDNLGGFFLPLSHPLGTMYTNDGSFDLWLQNQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J234</accession>
    <name>A0A367J234_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002491">
        <property type="protein sequence ID" value="RCH83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J234"/>
    <dbReference type="OrthoDB" id="2288096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="490" mass="55455" checksum="A0B9C01CDA792FDB" modified="2018-11-07" version="1">MSDNDAYAGNNQRSSPTLPEDSSKAFTDYYFLETFDFLDRYRAQQRYTNILSKYFNSNSERDMTINANYKTWTNSADYLRFWGKKKDSSSIMKADLAGAELIDSTLNRRLATSSCSANENIHATMIETNSVHQTKTTALADSDEAVISTHDAQDDSNTNEIKLVINDDVIILHEDTGSCKSGNPLMFKSTNNQHSPIAERVFSKPLLIDLTTNLVFEVVDLDLPFPKEELFTLTTTLSSLALGTTTREQTMLDLYIMSSKMEYGPKRIVRSVINLLQKLPNTPLNNHDAITETELWSTYYDPVLSCLVSDPDKLVHLRWTNSVPIEKGKARPDAVISEKPYLEFTTSIGFGEAKVKQRSGTRYSLCIDTLRLITFCKNAIDVNKLDGAMAFQIHGMHITFFLMRLVATGLYTFVEIAHLQFADSVESLPSFCTLMNVKKLLAINNVFWRYCKESAQPKKIEARYAKTLTTLNELIDEKQDSSRSCVLRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2E8</accession>
    <name>A0A367J2E8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002458">
        <property type="protein sequence ID" value="RCH84113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2E8"/>
    <dbReference type="STRING" id="86630.A0A367J2E8"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016481252" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="205" mass="23609" checksum="4342DDC1B2D740EB" modified="2018-11-07" version="1" fragment="single">MFSWSRIVFTILTLALLKTSLADEHNHVYKEGEEVIIWMNTVGPLHNRQETYPYFQLPFCQGPHSVEHHHETLGEALLGMDLVNSGIPTQFKINEADKVYCKQELEPKDVDVLRYAVDNQYWYTMFIDDLPVSGVVGKDEEEEQATEMDPHAKKLYVYTHKGFVFEYNGNQIISISLKHGNPVELKHGLSSLTFTYSVTWNPTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J325</accession>
    <name>A0A367J325_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002391">
        <property type="protein sequence ID" value="RCH84338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J325"/>
    <dbReference type="STRING" id="86630.A0A367J325"/>
    <dbReference type="OrthoDB" id="10480297at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="240" mass="26894" checksum="F80E04969657C2D4" modified="2018-11-07" version="1" fragment="single">MSLPSSVITVQACLSKRYPFKMLKSASISTPLLSTSNSALASVYFSRRKRPLSALVNHAIEDDPDTLGKIFEEASSQKEPDPPGTAAVPKEGLEPINTQSNQVSSDTKTNEEFKKATHRRKKLVVKKLCKKCGHVSKNDYSGLKTITDEVLCYHSYYLEFCTDGKYFYHTKCPEAAIARDSNNISPLSEEEESYPKAPTMPSSDVHFDALSSSPTNFNMLPEREDQEIKKGPEHNNYRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3B9</accession>
    <name>A0A367J3B9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002361">
        <property type="protein sequence ID" value="RCH84454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3B9"/>
    <dbReference type="STRING" id="86630.A0A367J3B9"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="227" mass="24557" checksum="583A927E02836381" modified="2018-11-07" version="1">MSSARTFLTTGKKIVAIGRNFSEHAKELGNAVPTSPFFFLKPTSSYLANGGTIEIPKGCEVHHEVELAVVIGKEARDCPASQAMEHVAGYALAIDCTARNLQNEAKKKGLPWSTAKGFDTFSPISEFVSKEQIPDAHNVDLWLKVNDKFRQQGNTKDMIFSVPKLIEYVSSIMKLEVGDVILTGTPSGVGPIQSGDLVTAGMKAGTANEDVVQIRFDVADRQGLFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J403</accession>
    <name>A0A367J403_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002303">
        <property type="protein sequence ID" value="RCH84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J403"/>
    <dbReference type="OrthoDB" id="2157517at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="155" mass="17487" checksum="0D1E5BA2C9D2A483" modified="2018-11-07" version="1">MTMDDRGKLNHQMLMDSITHKEYSGGIRNNLVGKRGILRQACMGIRPLMMIRGRHDNSIQKDYQQASIAVLGPQRYKPSVGVHRAIYQHLNLDFDDEIHTAVVSSVAVIEEIQSLIQKDPLFNKFLVEAVLDITSEMTANLGGIAKLEGYSTRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5N5</accession>
    <name>A0A367J5N5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002147">
        <property type="protein sequence ID" value="RCH85240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5N5"/>
    <dbReference type="STRING" id="86630.A0A367J5N5"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1257" mass="142860" checksum="2F21B63C63F8DC5B" modified="2018-11-07" version="1" fragment="single">MDFIRAITRNDIDKVRTMVQSGADVNSSVLWNSKDTYSPVIPPDRINRPDLINNDQEYQCKPLNIAVLGGHADMCRLLLSAGADINSKDGRGRTALICAVYGIDLDASNINTSNLDLIAQTNPHHFDIMKNIIMCHPNLHYATLDSPQYEIKGITPLCLASYLGKADIIQLLLDDGRVNVDGTDSKNATALMYAARDGNVPIIKTLLRYNASPDVTDSHGWSAIQYAERNPEIVQMCEQVLRVKRAEYATTDDVPFKYPLNYSKLSHLISTMPNYPSSLSHLQFDTLPELDILDPAAQPLIHIIQSAFLQAIKTHDHVSLQTLLMKPPQLNPGQPRQGPPILINHHDAKTGLTPLHHAMRAKPLPSLDTIKMLYYAGADMNAQTYYGRTAIHHLSRFGADKEGHWGIQKSNTTPSQNNGHVPIEGINVPHHLATCASLLIRLGALVHIADPTGNTPLHFAAEFGGVAEVIEVLILEGGADIHYKNKKGATPLDLCKSEELKRKILALDQERKNSNKTKSIYSSSGTIRPFDSASEYNRTSLTLIHRPTSLFLKDSRAECNDFEIILKSFFNYQTTFTDSIEQSLAYLTDSIVGNWPKKDESMSMIQQLEKTIVQLRYELREAHEMFDTTDQRVEKVMMAFREELEQIEQIHQADWEMSELQHDKTEKLFDVFERIDGRYSQLEIAQHELVDQIETLRKTISRRQPQKAVTEHDLGSGIVHLFQTLFILQTVPVDPALHVRDDKTRLCHDLQSVVSQVIDEINRYLEQLDDADKISQLKDAKASIEQRWLVIKEEFTQDDIREFPSIPMPSTALTKPSVKGKKRINEDQVYNLNQLELSFDILHSNLYEIQKDIQVITEQTEIVTANKKKMYELCISLEKELSSDTTEGKRSEKDIKTELNQVMYWTQQLFNKQHVLDIEKTQLLKEYQEAEKKLNETRVSLQKVRPHVLLQGLLERLDTDDVCLSSYIKVEKDWKEDTNLVMEITDYMPHVDDVDDDDDDSDSAASTTHSELTALQIKQIDAQCASKLSALCYMTRLDASLYCLKVLTHKFIIRSRQNLLEIQAMLAQASTELEDIRNRMTQLYDEAAEVARQVFALKTELETIVRHRKEEVVKVWEVVDEVSEGVKAKMAQYQKVKQSNEPSKQLHQAQAVSKETAGGVEEQDRHQWIIRELEQLQHAYEGLQSAIDDLKQEQAMIGQSLKQLSTNLIEPQVNSLVGQDPTSLLSVSDQLTELIERVKEGELGLRPISFWSQMFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J601</accession>
    <name>A0A367J601_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DiGeorge syndrome critical region protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DGCR14_2</name>
        <name evidence="5" type="ORF">CU097_007595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002121">
        <property type="protein sequence ID" value="RCH85346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J601"/>
    <dbReference type="STRING" id="86630.A0A367J601"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="523" mass="58666" checksum="0E7426C1E7928B01" modified="2018-11-07" version="1">METNNYIESWHNQLMTTYLQRKRNRRLDFFILVDDVHTGFMHNTARMAADIRRMGSKTREARKRMIAAEEINELPLEGVLMKNLKAHTMGEAALIQNTVENDHIEAATDSSDVLQSETPPEAGDRTNELSTSITSVRRQVLESHEDTYTEAISFIIERDFFPNLVKMKAQQNYFQAQQSGTLFDLQKASKALRDAQQPKKAEKKNQSINYYFEQESELEKRVNLDLSLDQFQTLYTSEDNASFAEILEKANQKAKEKNKWFFDKESNQLRITNGTQSVQLIEGPTGWKYKARNALMYYPEGKSESWIKEGDARGQPKAIDYKNTDITIPLTTQEDKPSSDIATQQGKVTPWTQLNQVDQHATSDASPALRGYQLVASTPALSPSRVGTPQMTWGSIEGTPMLVDGSATPGPKFSLPEISRREQLGMKLSEKASRAYRKKTSERVSKGTPRSGAGLMSPAAQHLLRKSQNSPHLQRTAFGDALRSAYGSSPLRTGSTVRRPGGTPTPVPLFRAGATPLAKNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6V9</accession>
    <name>A0A367J6V9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-nitrophenylphosphatase</fullName>
            <ecNumber evidence="4">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01002049">
        <property type="protein sequence ID" value="RCH85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6V9"/>
    <dbReference type="STRING" id="86630.A0A367J6V9"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="442" mass="49408" checksum="B23DB7553EAB3BBA" modified="2018-11-07" version="1">MLQYLKTKEEREAFIDKYDNFLFDCDGVLWEGDRMFDGVRESMKLLREKGKHVCFVTNNSTKSRKSYLKKFEDFGIEAKIEEIFTSAFATATYLKNVLKFPTDKKVYIIGMKGIKEELALEGIQSCGAEEDSGLFDNDPVPDDKDVGAVVVGLDTQVNYKKYSKGFAYLTRNPGCYFIVTNEDSTFPQHGSFYPGAGAIAAPLITALDRRPDAVLGKPALNMLEAIFAEYKIDPSKTVMIGDRLNTDIEFGLNGGIDTLCVLTGVTTKDELLSEENKVKSTYYIDGFGDFEWKEAFSLYDKKGNSTVSSSNLGDLLRGLGQNPTQAEVRELIKETAKSKNIPENQGKFKFLQFDIDFGTFLSILTRPDGFKPAGSSQEFIQGFQVFDKEGDGYISAGELRYVLTNLGEKLTDEEVNELLKEVEVGKDGRINYVDFVTVVLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7V9</accession>
    <name>A0A367J7V9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA mismatch repair ATPase msh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MSH1_1</name>
        <name evidence="11" type="ORF">CU097_005122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001964">
        <property type="protein sequence ID" value="RCH86000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7V9"/>
    <dbReference type="STRING" id="86630.A0A367J7V9"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="9">
        <location>
            <begin position="322"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="653"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH86000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="847" mass="95898" checksum="67EB5DF1B1B346F4" modified="2018-11-07" version="1">MKLSELVQKGNLSAKSLDKKEISTGSIVLDTVREYTKKYPLCVLLVQVGDFYELYESHATRYAPQLDLKLTRKAITANTVVDFAGFPLRSLDRYLDILVNRLQCRVALCEQLGAASRDDRSIMGMHRRITRIITPGTVIEERFLEANQYNYLLSILPSTQDKLGLAWVDISVGEFVMQETTLDTLKDDLARIRPREVVLPESLKPSDEVLQQGLFDLDVYDPVTRLLVNDPSITVSYQMDDHFNASAGFKAFQALFTKFAETSDFGQLELGAAMALMAYVSETHVNKTIKWQMPTRFSIHDTVRIDSAAMSSLELVKTLQGRRNDSLLSILDCTCTSAGSRLLNRWISSPLTNVNEIKKRLDVVEYFSQDSFLLQDVRHLLRQSTDAQRALQRLALKRGQHSDVFEVWSTLDIIKNITGKLKNAEASALRELVESMDPHMTISQHIQDAFDYEKIQSKEIKEYGFVNHAFHPELAQLHNEITELEQQRANLQDDLRELCGNSVILQSDGLFRHIVEVSTRQSSHLLQRFPQAQLVSSTKSKNRYQIEAWSDISIRLSTIQSRIIEIENQVFDQVVDRLLDHSTTILHSCRILAQLDVLASFSHLALERQYVRPRVTKTSRTMIIGGRHPVVEANLAKKGISFVANDCILDRDERIWLLTGPNMGGKSTFLRQYAIIVLMAHIGCFVPADRAWIGVTDRIFSRVGAADNLAQNQSTFMVEMSEVSTILKLATEKSTVIMDEVGRGTSTAEGFSLALGILDYLHNSIKCRTLYATHYHELADAVKEYEHIKCYMTNIEEDHLGRFRFVHKVQPGVCRQSHGLKVAQLAGLPAAVIDKAKAVWSQMETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J849</accession>
    <name>A0A367J849_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001936">
        <property type="protein sequence ID" value="RCH86117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J849"/>
    <dbReference type="STRING" id="86630.A0A367J849"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43721" checksum="C2180096D65635E7" modified="2018-11-07" version="1">MEAYGRAGDFSSAIRLLTGYHSKHKQLPNSMVTSLLINALRHDNLVVAENALKFMSNKGYRLADTDGVLRAAILWFKTRRDVDAARQYFNDLYMNDKRFVNSVMVNHLIKEYGRRGDKPNVLDAVQQRFNLANPQTTEEKRRTNHYLINALFHCRDVPAALGVFIAMRNEAVPDQVTMAMIIKGLIANNEADLAWRLFKTLQKNGKEPNLHAYTSILQSLADRNFPQKKKSNAQLNSIDPKLLKFAGIGSSKLDFQHSPVPVTTEALILFRRLTGFYQPNVYIYTTLISCFATKNIYQAINIFEHMCSNQVKPTVVTYTALLQGCAIFRKSDLAIKVFNHMCENQVEPNEITWHYLLKGLVRSHVDKKQIDKIGQVARTAIKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J881</accession>
    <name>A0A367J881_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001929">
        <property type="protein sequence ID" value="RCH86147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J881"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="12514" checksum="51301D28B187AC55" modified="2018-11-07" version="1">MSLSQIGLSLFPYQYVSSRVITAAAAATASTSTTANLVQPPSFLGGIILQFTRQVMKPKVIIPALLVIVLLFDLDDDVLNIDDDFVISDDEEEQQQQQEEEQEENEEEEPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8B5</accession>
    <name>A0A367J8B5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNF277 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001947">
        <property type="protein sequence ID" value="RCH86069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8B5"/>
    <dbReference type="STRING" id="86630.A0A367J8B5"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="61695" checksum="84C37C8F58A43839" modified="2018-11-07" version="1">MAEDTEWHTVSNHKHATHHPASPPQSRNRRQSKPKIHSHQTTTSSKSGKDKKPANKTSESGKPQTSKSATTHSKKHSHGKKPQPKRSTSVKKPTASRGKSNPFHAAEQDEESEEEDAEGHIDPIDLPVPPYHTTTFVTCPFDSCETPAPFLDTTSLVTHLKQAHMLVFKNLHHMYNSLDAYLQQWAKVLENKPLEEYGQIDPQEEGIYIISPEKCSLDKEMREKINRTKLNEVLKFQQYEREVESKCPRKCLFCKIVGEDRTSLFKHMFSEHNFNIGLPDNLVYVTEFLDTLEAKLSNLQCLYCEKIFTSPAVLRKHMRKKKHFKVAAKNRQYDRFYVINYLEPGKNWESFEQEAYESEDDDKREETWDDWEEDEPESTMCLFDTTVLSCPKDILEHMKTEHEFNLSQIRKDKGLDFYQTIVLINYIRHQSSLNTCFSCGSVLENLSDLPAHLKENKCITKLSTDAEFWKDPKYLMPTYENDPLLTGFEEDDNNLEEDDLLEISEAEANKKFLHQVMEKSLSISDDTILNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9K3</accession>
    <name>A0A367J9K3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS-type drug efflux transporter P55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_003470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001826">
        <property type="protein sequence ID" value="RCH86632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9K3"/>
    <dbReference type="STRING" id="86630.A0A367J9K3"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH86632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="556" mass="60331" checksum="5D88AE2084C5E435" modified="2018-11-07" version="1">MSSSTDLGQRSSNDSQVNEPTIYVSKESNNQYSENFKTRFEMFRFAILITGICLAMFMMSLNSTVIAPAMGIIATQLNAAENQTWIATAYLVAINAFQPLSGKFSDIFGRKAVFLFAIAMFFIGAIISAVSNSINILIAGRAIQGFGGGGVMSMTYITVTDVTPVPLRPRFQSILAVIYGIASVVGPLIGGAFVDHASWHWDFWLNVILAGIAFVIIFIFLKSPENVAQESFVHKLKRIDYLGTLFATGFVVCLLLALSWGNSYGWKDGHCIGSFVAAGVSFIALIYVEGWVAKEPLLPARILLNPACTTAYLYMIFLGLIFICALYFGPVYFQAVFGADSTQSGLRLIPFMVCLIAASVGGGILIRIFPYPKYFIIFAGASNLICYGLFQLVNPSSNWGQQAGFLAFGGLAFGLSNQNAIFTVQSSVALKDIGVATTCVNFFMMLSSSVGVCIYQTLSATFVSAQYAGLPTEVLKVANEYGALKNYLFIRKMPLEYQQPVTHAYAAAMRNLFIIPLVASGLSLVVAIFFKPVRYGGSATAVSTKQEIDIEKESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9U8</accession>
    <name>A0A367J9U8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001810">
        <property type="protein sequence ID" value="RCH86708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9U8"/>
    <dbReference type="STRING" id="86630.A0A367J9U8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="247" mass="28241" checksum="1A6A72DFB5C83C3D" modified="2018-11-07" version="1" fragment="single">MDKEKQAVLIIDEAKSDNQRFINTPEEKAFVRKLNWKVLPLIFFIIMIQFCDKSALSVAAVLGIFDDTHITEDQFSWVGSIFYLGYLICQPLNNYFIQRLPIARYFGSVLVLWGIVMTMTSFCHDFSQLAACRFLLGFFEGVSYPCVYILLNTLYRRSEQSFCWGFIGIGTGMGTVIGVVIAYGIAHMEGVAGMHAWRWGYIVFGIATVVIGVITFFFLIDDTHHRLLHLSEIELEIVEERTRDNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA40</accession>
    <name>A0A367JA40_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001796">
        <property type="protein sequence ID" value="RCH86780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA40"/>
    <dbReference type="STRING" id="86630.A0A367JA40"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="259" mass="29103" checksum="DA905BBF4E7F202E" modified="2018-11-07" version="1">MIQSVSMLNFADSCFIEIDLSSKEGRHQWYCLSKLIFFSVIAISKYQEQMSIDIETSPSVSIWKAAETGDIEALEYFLQHNTELLNMRDPNTECTLLHLLVSNVQDPIRPLELLLKHGVDVTAQNIYNVQAIHAVFLNCPYPLEAVRLLLSYDANPNARDGDGWTPLHYAARFCQLPEPVLKLLIDAGADVNAVDVNQKSAIFSLLANGDHSQTLDWLIHTARANLKIKGDFVDSLTPPSQLRDGNAEFAVCFDERRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAG5</accession>
    <name>A0A367JAG5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001766">
        <property type="protein sequence ID" value="RCH86927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAG5"/>
    <dbReference type="STRING" id="86630.A0A367JAG5"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="10175" checksum="C10A412C0FC293DC" modified="2018-11-07" version="1">MNPSRTDAKKDQFMGNVKEGAGNMMGNERMQSEGQTQQGAGNVQETAANVTGYVKGAMDQAAGAMKGAFNSLTGNTTGEAGDKVQQKKGEAQKDWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB25</accession>
    <name>A0A367JB25_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001720">
        <property type="protein sequence ID" value="RCH87138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB25"/>
    <dbReference type="STRING" id="86630.A0A367JB25"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH87138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="64" mass="7089" checksum="7FF523A0CA6C4C31" modified="2018-11-07" version="1">MATAPTIRQKNMLYKNRAVNHKVAAKAAEKTKAVSKANYSVWVIALLCFAMFGGAILQIIDLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB66</accession>
    <name>A0A367JB66_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ACH1_1</name>
        <name evidence="6" type="ORF">CU097_010220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001708">
        <property type="protein sequence ID" value="RCH87193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB66"/>
    <dbReference type="STRING" id="86630.A0A367JB66"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH87193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="373" mass="41731" checksum="0E490CC2512CB747" modified="2018-11-07" version="1" fragment="single">MATVSAALKSRVRRPQLLNKVMKPEDTLQFFKGGQYLGWSGFTGVGYPKMVPLALADHVEKNNLQGKMKFNLFVGASSGPECEDRWAQLDMIDRRYPHQVGKNIKKGINEGRIRFADKHLSMFAQDLVYGYYTKDKKDNNKLDIVIVEATAITEDGWIVPGASVGATPELIQMADKIIIEVNTRIPSFEGLHDITMSSLPPHRKPYLIMNTEDRIGTTAIPIDTEKVIAVVESNRPDMTGPNSPADAKSQAIADHLIEFFEHEVKHGRLPENLLPLQSGIGNIANAVIGGLAKSPFKNVTVFTEVLQDTFLEFFDSEKLQFASATSIRFSPEGFERFYNNWSTYKDRLLLRSQQVSNSPEVIRRLGCIAMNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB74</accession>
    <name>A0A367JB74_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER membrane protein complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EMC8_1</name>
        <name evidence="3" type="ORF">CU097_005958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001720">
        <property type="protein sequence ID" value="RCH87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB74"/>
    <dbReference type="STRING" id="86630.A0A367JB74"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15312" checksum="4AA24FC066EA7A7C" modified="2018-11-07" version="1">MTSIQLDVSAHAIPLLHAAKYPAYSVCGVLLGKVNGSNLHITKAIPFFHHWITLSPMLEVALRQTEIYAHDHKLTIIGWYHANEDKDDTRLSDGTKHVAETIRKQCGHCVVLLINNKVFSQPDEAAFIPHPLSKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBF2</accession>
    <name>A0A367JBF2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001695">
        <property type="protein sequence ID" value="RCH87258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBF2"/>
    <dbReference type="STRING" id="86630.A0A367JBF2"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050949">
        <property type="entry name" value="GPCR_Fz/Smo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31787:SF3">
        <property type="entry name" value="FRIZZLED AND SMOOTHENED-LIKE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31787">
        <property type="entry name" value="G-PROTEIN-COUPLED RECEPTOR GPCR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016785273" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="8">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="221"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63028" checksum="E98C650CB944FB09" modified="2018-11-07" version="1">MLIILFILSFIPFIIASPVITSGTCTRYPANASCSNFIDYNVFLPNGTTLETVEASLQQYKQLGTEFGQVSPVCFDAFSRYICSKAYPKCQTSSNQTSVYTACLSSCEEADAACASLFKMAGYAQLLPNCTTETTSIGSPLQPDNSCNNIQSKMTPQQVDQGKLNISAAPPDFIIQQCPAPFVKDTLASTGEGKTLDPKFCQFGCCIPCPAQNLFYKDGWAKKGFTATNAVRFVSAILSAILCISYLVLPDKRRHPSLLILNLALSIFFFSMTSFFSIGNPERLQCSANGVTPGEMGNNALCAAQGAILVFSSFATTLWCCALILNLHVHTVWKSNFFVDKYLLLNIICWGIPTVITCIALGLHSLKFEFASLCLVKMEYVFKLYFYPLAAIICPSFLIHIGTFFYIATVAIREGLESDMSQSLSTGNVSERPQGVSHRHLVVAVKIQWRALLLAVVAIVTILFYWLAYMTQVNRIATTQAEGTLTQSWLQCMLTPGNSQNTCYEILKSSLPSFPLMVTADALAGLIGCWLFILFGKRSLWREWNDLIYDLRIKLRGKRGEKYGEQFFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCS9</accession>
    <name>A0A367JCS9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001603">
        <property type="protein sequence ID" value="RCH87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCS9"/>
    <dbReference type="STRING" id="86630.A0A367JCS9"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21380">
        <property type="entry name" value="CTWD_Cns1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="240"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="355" mass="40910" checksum="C41CD33147F9D5C4" modified="2018-11-07" version="1">MSETVEQPNQEVGPKPYKGQFAMDPDNLDAELSKIPLFMTQLPEEENDTLSALQSLVFDGTPEEIAQNFKEQGNDCFRAGKIKYKDAITFYTKAIETECKDQKIIEACLANRAQCNLELQNYGRVLSDCSKCLAINPKNVKALYRSAKALLALDKLVEAIDCCDHALAIEPDNKAVKEVKQKAVDRKAMMDKKLKEKEEKEKREREKKEGLERAMKERKIKIKVEDKDVRERANIEYDPETDTISWPVFFLYPEYKESDYIQSFNETNTFQDHLEVIFEHPAPWDAKHEYTADSVEVYFEDTRGLNPKLIKIGKKLPLGKILSLDQYIIKNGVPSFIIIPKNSTFKQGFIDKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDJ5</accession>
    <name>A0A367JDJ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001553">
        <property type="protein sequence ID" value="RCH87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDJ5"/>
    <dbReference type="STRING" id="86630.A0A367JDJ5"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="17272" checksum="3BBB47A410EEB19D" modified="2018-11-07" version="1" fragment="single">DAESFMKMMRINALSAFLAIKHAGIAMQQTGKGGKELSGGSIICTASVAGIRSGAGSPEYSASKAAVINLCQTASYQYAGTNVRVNAICPGLIETGMTKATFDYAKQRGTSHKIGQLNPTRRYGVASEIGHVIAFLASDEASYVNGQAIAVDGGLSASHPVVPGKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDZ2</accession>
    <name>A0A367JDZ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001523">
        <property type="protein sequence ID" value="RCH88140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDZ2"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24685" checksum="E165BE4294F3DFDF" modified="2018-11-07" version="1">MSSIEKAEVKHHETVAMPVESSYAEEHHLSQHPMPHPHTGGEALRKLNPAPIGFGAFALCSFVLGLYNTGLITSLPQVAVGVAFGYGAMGQFICGICELIIGNMFAATTMLTYSGFFITFGVMMVPGSGFLSAAMESGGLAAVEKCMGLVQLGYAIAALLFLLGGLRQPIVVRLVLLQVFLAFFFGGVGGLAQVPKLTVASGWVSFTLALTAWYVMCGLLYTPDTTMIKIPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE35</accession>
    <name>A0A367JE35_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_009203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001515">
        <property type="protein sequence ID" value="RCH88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE35"/>
    <dbReference type="STRING" id="86630.A0A367JE35"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="24773" checksum="9F79AC88B75DBBE2" modified="2018-11-07" version="1">MAIHSHLSFASSLHPKIDTRIELDDIHEDCFLDIVYELPASVFVDPYQLRDMESRIGKAEVFGEHDLELPLEKVKEPRGSIVLLRQTNLTSPIHIQLPIHTRYQKPASHQQYQTVTIKVPYAGWTCGASSLPPIDHELLIPYNRHHLNSRFIPISNIDPNEQLELSVPVGSTQDRQLVTLGTFCIVILCSAWIVRSILVSVKRRKRTEAKGKRRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGH7</accession>
    <name>A0A367JGH7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001400">
        <property type="protein sequence ID" value="RCH88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGH7"/>
    <dbReference type="OrthoDB" id="2234898at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF256">
        <property type="entry name" value="OS07G0242900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="62725" checksum="CAEE6C4B9B551AAA" modified="2018-11-07" version="1">MTTFTTHFPFELFDRICYYLTNKQKAICQSVCQSWRPLFAASQYRHVHIQGQKQFKLFYLSLIRNGFYINTLIIQDVYLSSDQLESLPFLCPNVTTLTLAAVELSGTADGDIFSQWKYLKRLDQNIIPLLSFSNLSHLSIYLNHQSLTDILPSLQNAVYLKSLSIECQSLSLAELELIHEACPMLQELTLVNIHMENHLDAPVTTFASCMKVLQIQNAKGLDKGNAWIYYIAAKYPHAEQISLWNEHNQSFNEPVSPKEREDRYKAIAEIGYSCRGLRSVCFLNIPINHLFFKALEHVGTELENIGLGDMTDHTLETLKDLAESSQHVSHLTLWGWPSLCIQGMMEEMITLVGQCSRKLRSFEFSMKLSGIRNLHFPYKTLLDACSQLTHLKLDHIQTIPSQSNRHHLHLTQLTLQDCSFRNQLFEDLASHCPRLCHLDLDSCTLIDDPNKEIRIHMPQHSLQTLRINKIRPPSNYYHMRLVREVKYFYITDASKKRHVYELTDYDQQRPTNCVRIESEHVAGPYASIQCATLNELTIAGFLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGI0</accession>
    <name>A0A367JGI0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001358">
        <property type="protein sequence ID" value="RCH89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGI0"/>
    <dbReference type="OrthoDB" id="2264689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="260" mass="29465" checksum="7E43FBFA67EE8E52" modified="2018-11-07" version="1">MGLPIWKPRRRSIDEIQEDVHKQQIQMARSLLRQRVNTEGMPVITRHSYESALHTPSHVRRHRISRRQNLLTSSFGDRRPNSNSSVEQSELDRRIDQCISEKEDLLEQLQVTVSLLDQFLSARTRLGQEAVNIPEFITQDLPDILESATSLAAMSPSELVFSSPTINTSSNVQSVVEALLQIPPYSTRVQDVEANILSAHRRIRQQLNSLASLRRIRSPSPSSRSPPRSSPFSRSSSSSSTPRVRSRRPRVIFIDTDASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH73</accession>
    <name>A0A367JH73_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001323">
        <property type="protein sequence ID" value="RCH89246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH73"/>
    <dbReference type="STRING" id="86630.A0A367JH73"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61847" checksum="A274CA3CB8EA38A5" modified="2018-11-07" version="1">MNYETLDIIQKNLIHLIEKWKPSRQSNTQWVATLGLSGIATYFLCKTVIYRLYIHPLNRIPGPRVGWIPFMGNFFDIMKTDVDQSPFIRWKEQYGGIYTVHFAWNEPRLIVSDEKLLKQILTTQQYDFEKPLFVSKNLRRVVGNGVLLAEGDVHSAQRKMLNPAFSVHAIRSMVPLMTTPAYKLRDQWLKKMTESKSEYTEIEVSLGLSLATLDVIGLTAFGQDFKSVENYGTERLHKISKAYLHIFNDDFSWSHILQFAFPFIKYLPTRRLFNRARSLRWLHEEAEALVEAGIERSKKEKASDMNGRPKDLLALMVDLIDEGTGQGFTKEGLKEQCLTFLAAGHETTSNTLSWCLWLLAQHQDVQDRLREEVRVLFQDESSFDYETINSISYLDYVCRETLRFIPTVPRTSRVNRVPVTLGHYTIPKGTVIHITPISMHRSKEIWGEDADKFNPLRWEKGDHIGNAYQYMPFLTGGRQCIGNRFAMLEMKVFLSILLHHIQFFEKPGFKVRKIQLVTTKPVPNMTLFAKPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHB2</accession>
    <name>A0A367JHB2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001349">
        <property type="protein sequence ID" value="RCH89101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHB2"/>
    <dbReference type="OrthoDB" id="2317425at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54705" checksum="DB00304867DAF1BD" modified="2018-11-07" version="1">MQQSRFLNLPNEVLEYIIHLSSIKPYDDTDFLGWCYPEHSYTHLKSIALCCQRLYKLCSPFLWKHKEFILPRQHDVKKESIIQIATDILATPSALPSIPLVLGDHVCSLYRNLTTSPHFDLINSRLMAQLVCNLKALRVDFHPLPRTEHYGLRYFFEYCPHLTEVFISHCQDTYDDFDALCRYKPKLTSLTLIDCTVKERTLEIMMDLFRPTLKRLLFRQVLIEPSINTTQLTSHLLTAAASEARLGFLHPLHFQNSQATGIPQSMYIKASCNLRQLALTDSISCSTLEQITQASPLLEKLAIVLHDYYPEQIARSLTAITSLQRMTVLSLSFRKHYPLSREFERFPCHAPSSVWSYFATCLPKLKSLYISSSRLLISYEFISNLLQYHPLIVDVMIYSISFTQPPIPPSDDSLSNLRDTYLYECRYITYKIPDEYRHYLYTGQEAIQQSYNRVIDDASDVQLCFIKGYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHT4</accession>
    <name>A0A367JHT4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="14">ETF-QO</shortName>
            <ecNumber evidence="14">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_004073</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01001280">
        <property type="protein sequence ID" value="RCH89487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHT4"/>
    <dbReference type="STRING" id="86630.A0A367JHT4"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000012">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="12 14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH89487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="615" mass="68295" checksum="3B77B3F44B1A6AF8" modified="2018-11-07" version="1">MLRNTAQRIRSTLPRIAANQVIKVVRPSTAVRLTAARYLSHTRSQSIWLPFDRNSLPEDDPRRMEPFVDETDVVIIGGGPAGLSAAIRLKQLANEQGKECRVMVVEKAGEVGAHTLSGAVLEPRALNELIPDWKEKGAPLNTPVTKDSMRFLTKTLSIPLPHPPQMNNKGNYIVSLSNFVKWLGEQAEELGVEIYPGFAASDVLYNEDGSVRGVALNDVGLDKNFEPKDNYERGMQIQAKVTLFAEGCHGSLTKGLVKKFDLRKESGPQKYGIGLKEVWEVQPEKHQPGLVTHSVGWPADMHTYAGSFMYHFEPERHLVAIGFVVGLDYENPYLNPYKTFQMFKHHPSIKPTLEGGKCISYGARAINEGGFQSIPKLVFPGGALIGCTAGFLNVPKIKGTHTAMKSAMLAAESAFDVLFNQQPEGPIVLNNYEESIKNSWVYKELYQVRNLVPSFHSPLGLFGGLAYSGLDSLILKGRTPWTFKHKKADWECMKTAGECKPIEYPKPDGVISFDLLTNVSRTGTNHAENQPVHLRIRDAAKPVERNLAIFDGPENRFCPAGVYEYVDDENKPGEKRLQINSQNCIHCKTCDIKDPSQNIDWTVPEGGGGPQYVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHZ0</accession>
    <name>A0A367JHZ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD family hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001280">
        <property type="protein sequence ID" value="RCH89489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHZ0"/>
    <dbReference type="STRING" id="86630.A0A367JHZ0"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28621" checksum="8507C56A7B4CED31" modified="2018-11-07" version="1">MRILRNPLLVIDFDKTVTIKDTIALLAQFGIDHNKKSQPWSYYTQAYLHDYNQHCPNQPNHDSVSQLLHHLNSYKNVELASLTRVSQGKVFQGLTRDMLYEQGKRHQHLLQPDLVSVLSQIPKQFIRVVSVNWSKDWILGFLHELDLSRHQIYSNDLDFQGLHSTGDIIPSILTTGDKQEVIRAFQSSVVYIGDSLGDLEPLVNADVGIILGRDPSLWQAVNQFNLNLHRVDHWLQIKKILQSMVYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI43</accession>
    <name>A0A367JI43_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001268">
        <property type="protein sequence ID" value="RCH89556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI43"/>
    <dbReference type="STRING" id="86630.A0A367JI43"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="146" mass="16912" checksum="389FAAB45A0D2FB0" modified="2018-11-07" version="1">MSYLAGRTFYIKSQFNGRVLDVEGASTEDDAPVIVYTQKYDDNLNQLWRYENGYFVNVNSAKVLDIRGGQMDPESEIIQYSQKVYEEAVNQRWNIDEEGYIYIEARPDLVLDIQGAEDEDGVPVILYNRREGEVSSNQRWVLEPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIH7</accession>
    <name>A0A367JIH7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001234">
        <property type="protein sequence ID" value="RCH89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIH7"/>
    <dbReference type="OrthoDB" id="2269335at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="144" mass="16889" checksum="2CEB674E08EE3BE0" modified="2018-11-07" version="1">MMKYLKLELATMKITNSGTNGVLDLTRTAIIPKRLRTVVDGICQHYRLSLPMTLKNEEYKVLNIISNCRAKKNLYQSVEKIDPFCNDSELPYIKLAVQKLYNLWHRSVLTGDHNEDWYKVNVYGDLFDFIFNGQVGYETKRYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIP7</accession>
    <name>A0A367JIP7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA modification GTPase gtpbp3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GTPBP3</name>
        <name evidence="2" type="ORF">CU097_001331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001230">
        <property type="protein sequence ID" value="RCH89766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIP7"/>
    <dbReference type="STRING" id="86630.A0A367JIP7"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="13824" checksum="8E28405C1D6276BF" modified="2018-11-07" version="1">MTTSPVEPRMAHFRRIRHPKTGQVLDRGLILWFPGPRSFTGEDSVELQIHGGNAVVKGVLEALREIEDFRMAEQGEFARRAFDNNKLDLTELEGLADLLNAETELQRKLALQQAEVGWKVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJQ3</accession>
    <name>A0A367JJQ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vesicle trafficking between the ER and Golgi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SLY1_1</name>
        <name evidence="2" type="ORF">CU097_000373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001174">
        <property type="protein sequence ID" value="RCH90115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJQ3"/>
    <dbReference type="STRING" id="86630.A0A367JJQ3"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="150" mass="16574" checksum="0DA1BD548DD41C85" modified="2018-11-07" version="1" fragment="single">TGFSQNDLFRGFSSIGNKLSDRLKEGGLGGGFENLLSGVKNLLPTRKELVVSSIVSDIMSPPPNEASKASDYLYFDPKVSKNSKNPRQHKIAFQEAIVFIVGGGNYLEYQNLQELATQNNSKRKIIYGSTEILSPHQFLNQLATLGHKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL19</accession>
    <name>A0A367JL19_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001100">
        <property type="protein sequence ID" value="RCH90585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL19"/>
    <dbReference type="STRING" id="86630.A0A367JL19"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="268"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="542"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH90585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="615" mass="70609" checksum="BC87B6761A035FFA" modified="2018-11-07" version="1">MDSDNEEILPSINSDPANLINQMTYPTPPPLTSMTKTFSRSVPNSRRNSSDDHIDLLLNAKLSLNEPYDRKLSLAQESTNGLGTNMGLHDTVQSNTEGAAFFIHHPPVSKHTTAIKNLFPVVTTLTESTSNVWSPSFTSKTINPLLPESISGPTRRYSYEWNPEINDRYGNDSFIAQSRQSTYSTTDSMNHRRSMKEVQRQYYPMDSVFLSQELRFHMTSPATPSLYQQHTLSSHGPLLQTPFSASSLNTTYQKTKDRNGRHAKHDMNYSVNRRSSANQDRFVDANVSDFAGRLYDLCKDQNGCRFLQRKIEENANEELDLIFNDIYSHFAELMIDPFGNYLCQKLLEKCNDEQRIQLIQIIRPHLIDIALNMHGTRAIQRLVECVSTHEQIQYVISALSAHVAPLIKNLNGNHVIQKCLRHLSSEYNQFIYNAVCKHCVEIASHKHGCCVLQRCLDFATPQQKDQLVGEISKHTLVLVQDPFGNYVVQYILDLQVPNYIESINQHFIHHVCTLSIQKFSSNVIEKCIRTASPQTRRLLVHELIECETIDKLVQDSFANYVIQTSLDYADEDQREQLVYRIRPFLSTIRHAPHGKRIYSRIISHQRQNKDKILQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLC9</accession>
    <name>A0A367JLC9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001077">
        <property type="protein sequence ID" value="RCH90726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLC9"/>
    <dbReference type="OrthoDB" id="2284687at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9722" checksum="F6D9E2D0E5EDDB28" modified="2018-11-07" version="1">MISGLTIESTNWLLSACLEYVHSYLTQHQNVRRSTTVSSRPTLKKQKLPPSSLYLNSLSHKPIVKSAYSVSVPGTPDPESFHHQMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLN9</accession>
    <name>A0A367JLN9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001063">
        <property type="protein sequence ID" value="RCH90815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLN9"/>
    <dbReference type="OrthoDB" id="2201430at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6512" checksum="26D6B3CE63EBEE5E" modified="2018-11-07" version="1">MCDYPQPPVTITIYSSTRRRIVTTSMAFDIKPLNLQGGQCSWCGKYGHKRHICPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLX4</accession>
    <name>A0A367JLX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FET5_1</name>
        <name evidence="7" type="ORF">CU097_001111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001043">
        <property type="protein sequence ID" value="RCH90944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLX4"/>
    <dbReference type="STRING" id="86630.A0A367JLX4"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="662" mass="75423" checksum="6D3ABB97F9E906BC" modified="2018-11-07" version="1">MGPAGSGKSTYCATMMTHCQTAGRRVHLVNLDPAAESFEYEPTIDIRDLITLEDVMEELNYGPNGGLIYCLEFLVNNIDWLEEEIGDYEDDYLIFDCPGQIELYTHFPIMKRLCEALSRLNMSICGVYCLESQFIEDKSKYFSGVLSAMSAMVNLEIPHINVMTKMDLIEGDYGNKRASEEEEQDEDDEESAATQKRRRQRRRRRLLEKAMTERELDRYLEPDPLLIAEEAEVVYEGEEQPTARSLKFQALTQAIVQLIDDYSMVKFIPLNITDEDSIEYVLSHVDNSMQYGEDLEPKEPEDVPEYDVYCHNKYMEDDDDNTVLADILSLKISKENKRNSVTNWSKQRSPWLYQNKDKRQEQLQASLNQLQYLHQQQQTTNQNSLSSSSTRHEPPPSTRPTSAELWRAFIAHARGFRGANLTVFENAEAKAAVRDRHQDQLWVQSNEMNTVGSFTVISTPILPPTSSIYRVSLEKLPLMRLDSLIPLLTEALSRYGTVLHVGLYRDPPGHTKGNCPHLPQQRIKTCYSCGNPGYLIRERPKCNIATVSEKRARYDDPLPTVPMLSLSPTPIVSAISKSVHQSGIESSKMTANIQNNIEEDDADGPDYVPSDDQSESDESEHDSDVMSIDSQGRQDIEDDVRLLQSRLFCDVLNTALPTNLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLY6</accession>
    <name>A0A367JLY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_011977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001054">
        <property type="protein sequence ID" value="RCH90879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLY6"/>
    <dbReference type="STRING" id="86630.A0A367JLY6"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="753" mass="84727" checksum="EE6C24431FCCED07" modified="2018-11-07" version="1">MSFDQINTTRTENNETIKNIRDINDFENTTEQHDLPKPRKSKQRSPDPNASCYIHQLSIEVVTHIFARLDPISLATVAKVCHYWRHIVNNDVCWRDAFMSYFGKLPYKRLSLESWKTEYILRTHLIRKWTKSRGPVISFAPKIGSLESMYVDFEDASMIVASSEQGVAAKCNPMTGKIDRHLLYSTNEAIPLHVTATKVEKDRIAWGFQPGYITLLVRTKRSGHVANRLKVFSDFHQGPVRILVLPSTNQDIILSGADDGQIKIWDVASLSCAWTLTGPSAVAKPTCLEVTNDQRIIAGYNDGTVIIWNINLNHILQMSRSQRSENYQQAYTELYQKIEENKRVISPPRSCGIVTPVQSMLYDSETSMIIVAYNGRTEVKKFNVNTGLCTASFNDGHFVGTTITCMQWDTSPSYLSTLDEALKPHPDSKKKANIIHLTSPKSSGQNTPLSTSVSAKATRLLVTGDDLGVICLWNGDEVSKDGQIIKPIQILSGGHTVAISSIYVDAFKIVTGSDDGWIRMWDPLTGTNIHTLGNKIPKNAPIDRTDVDVMRVKNIWCNEYQGVATIGHQVKTWDFSPRKQLLNKKQLKPKGKFGNGNARDKYRYEIDQEVKDSIKKLENEKKERQRHEMKLSKLTLEGLSDEEMLHYALMLSQDTSAPDVAPQPSITHDDYVDDDEELLKAVIASLNVDQDTNEKNNFVGSSNTSNHSDAGSSDRDEWASATEFKTANLAATHEKNEIDKDLLYVLELSKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNH5</accession>
    <name>A0A367JNH5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000962">
        <property type="protein sequence ID" value="RCH91494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNH5"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="2">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="3">
        <location>
            <begin position="389"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="610" mass="70095" checksum="524EE155E9F43659" modified="2018-11-07" version="1" fragment="single">AEKEGREYKRRDYGQLLERRDFKSHGCWKDLCTILTIYAQGELRGPSGDEYKALKWPRTATTYRYAINERQERNRKRKEEMTREEAKKDAEIYIKKGAEHNAKAQAKAKEAKEKTRRERNERVTKLLQTDPLYRALHFTIARLFANQLKADMAQLQKNKDAIEQGVLKGRHALGFNLSLAGKWAPSLCRSHDKHTFLATSIAELLFPPEKYQDDGESREHYLNKIRDLYRKQYLAPLRDALDIVEHYKAEGKWKKIDFTHVPATCLKHNWARFYKHAPYAVTAFLNGSPLYVKKAKGEKCTTFSSNALPRRIKISGETILPGDLLANIFDPEVPKTLQPIANFDRDAKRKILDIQTEITNRQWEHLIESFRKTSLLNTSKSSNTVDLRECIAVCNLRGSMRYASSSELVHHSAALSLIIANLAKPPFDGSIIAYSKGPTAFKLDTSLPFDEQARQIMQRVHRSNDFDLKGVFTDIILPLAVKNKVKPEDMIKRMFIITDNNFNFGELEAEKLETAFGLIRRRYHEAGYEVPEMVWWNVADPDRCTMYDLKAPVSKDDAGVKLLAGTSANMLKTFLDGDDIDEDKAKQETPLDFAKKAVYHESFKDLVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP38</accession>
    <name>A0A367JP38_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000941">
        <property type="protein sequence ID" value="RCH91645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP38"/>
    <dbReference type="OrthoDB" id="2287527at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016819025" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="118" mass="13497" checksum="1A4A1CB8D1F90C9C" modified="2018-11-07" version="1">MKFLYLVLTLFLIALVHAAPSGEKSHDDFDIIFYGKPYYQDQVGEIHGSVAPGEGAGSKRGNMTVASYETQKWLQVTLYDDYYYKGNHITFLGPRKNIKPPFHVRSVKWKSLKNDLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPE0</accession>
    <name>A0A367JPE0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000926">
        <property type="protein sequence ID" value="RCH91745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPE0"/>
    <dbReference type="STRING" id="86630.A0A367JPE0"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="13535" checksum="76390365363EC637" modified="2018-11-07" version="1">MNWQKYINELVETEHVAEAAIIELKTGEILASTSDFNLLPSEAAGIAVLSRDYNHVFAQGVRVAGITYMGLKADATSIYGKRGTTGVTIAKSNHVVVVGTYTDGMKPESNEKAIEQLAAQLIQSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPR5</accession>
    <name>A0A367JPR5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uracil catabolism protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000910">
        <property type="protein sequence ID" value="RCH91859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPR5"/>
    <dbReference type="STRING" id="86630.A0A367JPR5"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46788" checksum="64A80A280EE3D230" modified="2018-11-07" version="1">MTLLPQEYLRTLPSIRERCTKVYEKAKQGESTSFDINEAALSNIVNHVVATTTRRFPDLSKIPPHSRLRHFDQNRLTELRQRWTRDNVDRVEQARRLIDLVLVSVLVDAGAGQVWKYTTREGERIGRSEGLALASFDMFLNGYFSSSADVPDRVDVRGLDKITTERMTQGFQVTETNQMVGLEGRSNLLKRLAQVLDEQATYFPSVHGEPRRPGHLVDYLLNNIDSTKNSIRIEALWGAVMSLGAMWPARVQIDGIQLGDVWPCAALTDLGNYENLVPFHKLSQWLTYSLIEATELTLGVTVEGVELMTGLPEYRNGGLLVDYGLLTLKPDEVKRATVKEDELPVFEGSDPAIVEWRALTVVYLDIIKAKVEEKLGQTLSLAQVLEGGTWTAGREIAAKLRPENGGPPIVIKSDGTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ09</accession>
    <name>A0A367JQ09_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-protein scj1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SCJ1_4</name>
        <name evidence="10" type="ORF">CU097_008824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000886">
        <property type="protein sequence ID" value="RCH92032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ09"/>
    <dbReference type="STRING" id="86630.A0A367JQ09"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016951837" evidence="7">
        <location>
            <begin position="23"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="383" mass="42938" checksum="52DFD838FC15D2C6" modified="2018-11-07" version="1">MRPSCLSWLLFAAVLLIAFASAKDYYSILDVPRDAPKAQIKRHYKKLSRVYHPDKNPGNDEASQKFMEIANAYEVLMDDEKRAIYDRYGEEGLKQNQGGGGGNPFHDPFDIFSHFFGGGGSRNARHQERRGPDTVIPLEVSLEDLYNGANIEVDVSKQVLCDHCHGSGARRPEDIRTCSTCDGHGMIIKRVQMGPGMFQQFQQHCTACGGKGKTIAHVCPACGGKKVRRGNENYTLRVEKGMKDGQSIVLEEESDEFPETIPGNIVFVINAAPHPTFERRGDNLYTTQHITLVEALTGFTKTLKHLDHSTVELVREGITQYGFVQTIKGQGMPLENNPSKHGDLFVEYQVIFPSEIDEETIEYLKKGTKYPTHQTPKLVHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQG1</accession>
    <name>A0A367JQG1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000864">
        <property type="protein sequence ID" value="RCH92192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQG1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="1">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="23264" checksum="CF9C864806092DF7" modified="2018-11-07" version="1">MYANNVNTSSASNNYEYSDDHIKSLGEIARNLSENGQFIPEVYCSKEEIREALLGYEKKFNVVLSIKSSIAYTVVWICKHSGDYRVMDREESATKRLKKSQKIGCGCYVKVKTNKLGHWLINEWEGRHNHPIFKSRSIYSQYRIQPEEIEERIGNMFKAGLSPSSIFIVLQSENIKNITKKDLENKYFHFFDLKRKIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRS8</accession>
    <name>A0A367JRS8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UBE2T_1</name>
        <name evidence="8" type="ORF">CU097_011840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000803">
        <property type="protein sequence ID" value="RCH92618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRS8"/>
    <dbReference type="STRING" id="86630.A0A367JRS8"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23805">
        <property type="entry name" value="UBCc_UBE2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="432" mass="49099" checksum="5841D0CF731AC2B6" modified="2018-11-07" version="1">MYSDILIKRLQKELRSLEREPPPGITCYPKEDDITQLEAYIKGPPDTPYEKGLFKLDIQIPLKYPFEPPQIRFKTLIYHPNIDDSGRICADILKTGGWKPALNLSTTLISLSQLLAHPNPDDPLDADIAKEYYIDYPQFKQKAEEYTLKYATKDSAEDNNNTNNFLKTEQEDKEEDDYELTIPNKASTSLLLLSKKKNKKQGTAKRSSTENDTGSIHTSNIPESTETLSTTERELSEEVEQTSENASAEDLTKDQIKEEHDENPEKHLPVVDISNQQSNNQNNKQKCTKRRSSQHKSKDRKQKLKEKEVAIVIDHIEEKEAENLDTTNYTEATSSYSRKEELISTQLEDGPDGHPTLFDGNTKATGKNGVKRPYSALELLDVIELSDDDDESDGNNKDQEAFSEPPLYTLRLSKKLSRTTLNLSKKKKTTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS57</accession>
    <name>A0A367JS57_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000780">
        <property type="protein sequence ID" value="RCH92780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS57"/>
    <dbReference type="OrthoDB" id="2286601at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="73" mass="8591" checksum="A060F1BDEAC58907" modified="2018-11-07" version="1">MKVWPCIIIGWFEKEYEEYLLLRQLIAEVEERINLATLVQQDIKKPVRGGKYGLLLPEQINACLLEKTVVQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS84</accession>
    <name>A0A367JS84_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_012587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000790">
        <property type="protein sequence ID" value="RCH92709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS84"/>
    <dbReference type="STRING" id="86630.A0A367JS84"/>
    <dbReference type="OrthoDB" id="3253553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="144"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="286" mass="31937" checksum="CA95C1F84BF3F3D1" modified="2018-11-07" version="1">MSQNNPFEDTSHNPWSDSGPKYGNAYEGSPSPALPPRVKETPTLVSSSPYGTQRMPSPSAYQQPPVVNAWQESNKTLDEPQHHTNAYQYSGTPYANSPTLANAYSPQPTHTTATINDINNNNNNNTKAESVNLPSATRTKPSKLRVLLRIILFIFAVGHLGFAAGASPYSGHSVPLDSSACFYYLFAVAIMSIIYSGFHVFFYLFRRFGKTDKMKRFILILCDLFMALLWGIGIIVEIAKYRCPPGGFDHWCDFYNTSIFFGFVSFVLYIIILGWDIVGGFRARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSB7</accession>
    <name>A0A367JSB7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation protein S66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SEC66_2</name>
        <name evidence="2" type="ORF">CU097_013430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000771">
        <property type="protein sequence ID" value="RCH92854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSB7"/>
    <dbReference type="STRING" id="86630.A0A367JSB7"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="24716" checksum="A18FEB43F8C14FC5" modified="2018-11-07" version="1">MSSLLLPTVYLGGCIAAMSAFSYVYRRATATQTVESWFPLNRQKEEYIALLNAEPAVPEFHLRTALLRRAMEAVRRLVQIQQEKPALQQLMKTGSIGDELWREFSAAEQEITAELQEIAMEANTFKENWGQTIFSTAAQMLEHEKQKQLQQEMKVMLEKETARKKREEEREAKEAKEQEAKEHERRLREAKKAEEELLKMEEQEKRAASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSZ3</accession>
    <name>A0A367JSZ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Importin alpha subunit (Karyopherin alpha subunit) (Serine-rich RNA polymerase I suppressor protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SRP1_2</name>
        <name evidence="4" type="ORF">CU097_012984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000745">
        <property type="protein sequence ID" value="RCH93074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSZ3"/>
    <dbReference type="STRING" id="86630.A0A367JSZ3"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH93074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="558" mass="62163" checksum="943B6FC312692E6A" modified="2018-11-07" version="1">MTLDEFQLEDDSLLEISRKLSNVTIGKMPTPGEELDKSATDPRVLANSDESHVEDILALGVLPRIKELMQSDNGNSLKFECAWIVTNIAAGTTAHTQAIVQAGFIDVLLEIINSKKAEVYLKAQAAWALGNIAGESPAYREELMTKGSSTAIVNVLNDIYEDIYDLALRDGRGRGRLYLLDNDYDVSTESLLWSLSNMARGGYRTADYYENYLIMFDAFAKYIMFENPKQVLEACWGLCRVLYNMHEVGAFYYRVDISVELCERLGELITSSPLKVVHAAIRTIVNISNGPDKYAMNLLQPPVILSFMQLLTPQTTTDVRKDAYLALSNLVASNEDMIDQIIQHRPIIDNVINHLAVPGHTYTHFNWEPSVSHAFCSRSEEWKVTKEALWVVLNLVTVGSDSAIYRLLSQHPTIPAALAALLNYIQLPTDVCEKTLECMISLVQRTNKCIGDQYQNGKNPYVRQLIDGRASMALSTIQQSNSTPKIWDLCSKLDKLLYVSEESVSQAAAMVDAGGMASAFGLPSMVEIQSKSQKRRVIRGLDDGDVRLIENAVNNLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTN2</accession>
    <name>A0A367JTN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphatidylserine synthase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_004309</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000721">
        <property type="protein sequence ID" value="RCH93245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTN2"/>
    <dbReference type="STRING" id="86630.A0A367JTN2"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH93245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="48590" checksum="26AAC4C0AD17CC9B" modified="2018-11-07" version="1">MKTTQEEEQEEILVVKQTKIIEKVVNNEENIFHPHTLTVLVVVLGLMFYAATRSNYENTEESIRLGILAAIVCFVLIGMVHFPDGPFVRPSKPVWRAALSLSVLYQLFLVFLLFLNKDDARQFMKYYDPELGVVLPERSYAEACDLSWDNIKNQMDLFVVAHTLGWFGKALILRDYWFCWIISIAFELCEYSLQHQLNNFAECWWDHWILDVLLCNWLGIHIGMKFCQYFSCKEYSWVGFRQIKSLRGKAKRAVQQFTPKEWTRYEWKTTSSPKNYFGTVLLLIIFLQCELNCFYLKSLLWIPPEHPLNTYRLILLFFFALPGAREVYQYISDNSTKRLGAHAWLLIFNIMTETLICLKFSENEFHESAPVVVKVGWSTAFIILFIIFPLWRFVISPAKKTEAAIKIEEIKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUS9</accession>
    <name>A0A367JUS9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tom7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_010510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000698">
        <property type="protein sequence ID" value="RCH93431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUS9"/>
    <dbReference type="STRING" id="86630.A0A367JUS9"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5646" checksum="B9DF9341A2AC2422" modified="2018-11-07" version="1">MNDSTKDTLYKVADITKTIIHWGFIPFVIYLGISRSNPRPSILKLISPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW12</accession>
    <name>A0A367JW12_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Lon protease homolog</fullName>
            <ecNumber evidence="6 11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_005822</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6 11"/>
    <dbReference type="EMBL" id="PJQL01000615">
        <property type="protein sequence ID" value="RCH94120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW12"/>
    <dbReference type="STRING" id="86630.A0A367JW12"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000382">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="593"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 9">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 9">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH94120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="793" mass="88900" checksum="20179DAA7E6C772B" modified="2018-11-07" version="1">MFINVSTLPTHLTALPLYDGQVLLPSIIKDFVVCKSESDRLVDTEYIICVPMVENNLYHFGCVGKIIEIDTGLPDKHVIKIQGVCRSRIQDITSTDGGETIQVTVINYPEEEQLPENMKKDLMEACYMFIEKLKSIGISMAVLNQLYKSVQRYPVSHMANLLLYLADSTPREKLLVLEMIDLQKRVPVIKNVLSRYLQSFNINQLDSIRRKFYICQQSNIISSMCHKEEKTTYYFDASSEDDDDLVHLIQKLNNANLPEYVISTVQRDLNRLRKLPASSSDSGILRTYIEYIGDLPWSNNVCQEINISFAKNQLDHDHFGIEHVKKRIVEYLSVLKVKSDAKPPILCLVGPPGVGKTTLGKSIATALQRKFHRISLGGVRDEAEIRGHRRTYVGALPGIFIHGMRQCGVKNPVFLLDEIDKLVQGTHQGDPAAALLEVLDPAQNPTFKDHFLNIPYDLSQVVFIATANNLDTIPAPLLDRMEVIQLSGYTYEEKLHIAQTHLIPKQIEAHGLTATSLKIPDDVVLYIAEKYTRESGVRELERLVATLCRYKCREYADLEEAGRLNDFDNAIYMHDIEHILGKEIYDNEAYHLEETAGIVTGLAYSSSGNGGTMMIEANYMPGYGNLKLTGSLGDVIKESAQIAVSWIKANAYALKLTSSPRQDILKDLDLHIHMPSGAIPKDGPSAGITMATCVMSLLSGIPVPRSIAMTGEITLRGQVRPVGGIKEKVISAHRAGIKKIILPVGNKRDIQHDIPTSIQKSMTFVYCKSMWDIIEAAFEHTSVRYEHRYTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWB8</accession>
    <name>A0A367JWB8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_013730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000601">
        <property type="protein sequence ID" value="RCH94233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWB8"/>
    <dbReference type="STRING" id="86630.A0A367JWB8"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38731" checksum="DAF7B898515826AA" modified="2018-11-07" version="1">MQQDDDLFEQERVSRSAEPTGYIDWQQTTKITMETRIPESNIGYKMMQKMGWIAGSGLGSHSQGRVDPILIEVKDETLGVGKAQELEETHVSSTAKRRALDSEKQLEETEIQRIEREYRAEKKQAIMKELEQVKRMFYCELCDKQYNKISEYEQHLQSYDHHHKKRFKEMKESTRNSELNQSERERRLAREKKREERELKRMQEAIQKKIGTTSTTSTASPISTVQADKGSWTAVPSLTQSGGWTNVPSSTPSGGWTNVSSKSSSERTSDQTSGGWTTVTSISASTSTNINSSNNNNSNNNSLRNSPGIETEKKKENSAEAPKKLAFGLKKTGGFQFGLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWM2</accession>
    <name>A0A367JWM2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000624">
        <property type="protein sequence ID" value="RCH94051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWM2"/>
    <dbReference type="STRING" id="86630.A0A367JWM2"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="177" mass="20047" checksum="35E249A94DE6DBF0" modified="2018-11-07" version="1">MLQNVHIKAGNVNKLYIYVHFNITNKTKAQCVSRRSLHMSRTLFEQNQIESIANQFKLSPNVLTQALTHKSFKHGNTPNNERLQYLGRRSLEYFAVDLNKSQNAQQLNQIIEKANESQHLVARFDALGLESAVRCQLPGNNVSPAVKSKVMQALVGAVYHEQGLNAAREFVKKTIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWP2</accession>
    <name>A0A367JWP2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000581">
        <property type="protein sequence ID" value="RCH94412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWP2"/>
    <dbReference type="STRING" id="86630.A0A367JWP2"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="740" mass="84032" checksum="72F801CCFB37859F" modified="2018-11-07" version="1">MSEQKRQRVSKACEPCRRKKVKCDGRTPSCGNCDITGSVCHYKDSARKRGPPKGYIEAIEGRLHRLEALLGSIIQEDDPRSQAILAEINAPIETAYGELVRPRPISEIESIPNTVNSNNSSSNNNNREDENTNDNLGNLSIDESGQLRYYGKSSGFYMLRGSKNFQNGAFHFNSRGYRSGETKHPLVVDPYELPPPDLSKHLLDLYFTHFYPLLPLLHKDTFLAALESEDNDKRPPHLLLNAIYAVASRISPDVRVRSDPDQRDTAGDIFLERARILLDHEWDDYKVSTVQSLLLLSSHQNGALKNIRGWLYSGLAFRMCQNLGLNRNCDSWNLSDAEKEERKRVFYCSFVIDRLSCAMHGRAPMIDDRDYDTPYPSEVDKDDEHNKPTIMDNFHQLIKLCEILGEVLCQLYMVKGRRHLATLASPDSVISKLDRALNNWMSKLPPSVQYKPPNTRMAERSTPPKLELCQTHMLFYTTLILLHRPFIPGPNQRATPSVFPSASICTFAANKILDIVECLMADGRLKNINNYTLYFMFTAGIIFINDASSNDPEFAFEAKVSVNKIIRAMDEVEATWITSARHCNILGELAGLRDINLENVGEGFDRQTIKNQSLQTKKAPSIAVPNSPVLQPEIPSLELFRNPLDAQNPAEQRFPEYLTQYANTSSFQTDSPSSQSLNQSIEYNMNNTYPSSDRTFNAIGTAFWDIPMSFDIDQWNSYFSNQNYRTQSNTNEENNDTQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXU8</accession>
    <name>A0A367JXU8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein memo1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000543">
        <property type="protein sequence ID" value="RCH94750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXU8"/>
    <dbReference type="STRING" id="86630.A0A367JXU8"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36127" checksum="A91EAA0BEB3C8D41" modified="2018-11-07" version="1">MSRPASHAGSWYQDDERALDQELNNYLNKATEAITTKGQQLPIQNVKAIIAPHAGFRYSGPTSAFAYTCFDTKNIKRVFILGPSHVCATRYCLLSKCKEYETPLGSLKLDISVIEELSKTGLFAAASPSTEIEEHSIEMHLPFVYKAFESKISDIKIVPIIVGSLTSDSKKEYAKALAPYLKDPETLFIVSSDFCHWGRRFRYTYYNEGRDDNEAVELTRSNAKKAIGRPIYESIEELDHRGIEAIESLSFDQFERYLSVTDNTICGRNPIGVLLAALEEIKQEGYSDQSAKCLKYAQSERCQSVEDSSVSYASIYIQVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYT8</accession>
    <name>A0A367JYT8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000505">
        <property type="protein sequence ID" value="RCH95067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYT8"/>
    <dbReference type="STRING" id="86630.A0A367JYT8"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="220" mass="24979" checksum="594B22234C12F31A" modified="2018-11-07" version="1">MSRLGKLENKEKPSMDDIDYVVCHSPYAKLVNKSFARAAYNDFLLDTENEKYAILKPFQSLTYAESLENRDLEKACMAFTKSGYTQKVSPCAFVPKQIGNMYTAAVWAGLASLISEVDSDTLQGKRILLYSYGSGLAASMVSFRVSSSTENIKGNLNLRERLDARTHSKPEEFAEAMALREKTHNVCDYTPVGNLDNIDSGVYYIEKIDDKWRRFYKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZC3</accession>
    <name>A0A367JZC3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STUB1_1</name>
        <name evidence="11" type="ORF">CU097_014244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000484">
        <property type="protein sequence ID" value="RCH95268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZC3"/>
    <dbReference type="STRING" id="86630.A0A367JZC3"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041312">
        <property type="entry name" value="CHIP_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18391">
        <property type="entry name" value="CHIP_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH95268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="31905" checksum="4A25A281A0CFA859" modified="2018-11-07" version="1">MSKEAAEQHKANGNKLFAEKQFQEAIKEYTNAIIKDASVPVYYTNRAICYLKLEKYDQVISDCRKAIELDPQLVKAYYLLGQALTEKKQHTEALNKLKIGYQLAIQQKVKYVNDILQALLLARKKKWEDDEAIRLEKESELLRYVKGLIEKERKELLEKEGTDEEAVDTINYNIDERLRKVENVFVQSRENATRRDIPDAYLDKISFNIMHDPVFTPDGITYERQSLLDHFKRNGYFDPITRKACKESDLVPNLSLREAIEDFLKDNGWAADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZQ5</accession>
    <name>A0A367JZQ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000471">
        <property type="protein sequence ID" value="RCH95400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZQ5"/>
    <dbReference type="STRING" id="86630.A0A367JZQ5"/>
    <dbReference type="OrthoDB" id="2258642at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="443" mass="50889" checksum="08E22256887D74BE" modified="2018-11-07" version="1">MASSPRFWQKLGLSKQSKASDKKDRLLFTSSMIEDEKQLKHSSTLRHIASSASIRISSPQLKRMTSQFQLAEPVSTTKPVDQATMDNKRSSIPVVQSISPPQRKSLERTGTRLKQSKSNQSIRSESTTTSAGSAKSKTSRLRQPSPARLRLSKSASSASLNNKKSLPKMSDQANNKCCCDHQGLLDTIKSLEESLEKERAFSRSLQGQKEAIAKDLDYFCALSDEITEERDRIKANYDKEKLENERLREALEDLQQVYFTFIIYNKAHRPILENMKQQVTEEHYAYYSNLQYKNEEISKLKNELKLAQRQIQVLRKTMEHMLKVDEQDLDDGETKRKSFYDTATTMNVDLLLHNHPDHRSSTSDSSLSSTKPPSPTAYFEEDSEDEPRESFLNEDRYLVKKRSSDLPKRLLRSQRRKNELEEMLGEVDSQLNKVKLRRPSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZS8</accession>
    <name>A0A367JZS8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000468">
        <property type="protein sequence ID" value="RCH95428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZS8"/>
    <dbReference type="STRING" id="86630.A0A367JZS8"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32105" checksum="B9EF71F143446AAD" modified="2018-11-07" version="1">MEPLSWLIILSVAMFIGSYIAGSLPLAVQLSQKKVHLLSSFGGGMLIGTCLVVVIPEGTEAIYKSTLQVNNTGQQHLQKRDPNVGSDGHAAMGIALIVGFALMFIIDQLSSQVIKPSMNGQEYSELEVISGERVRERDSEQHRHDTSTASVTGLLIHAAADGIALGASVTRPELSVIVFLAIILHKAPAAFGLTSLLLNSGLTKTSIQKYLILFALAAPTGSILTYLILGLFSSNVTSTEIEYFSGLLLVFSGGTFLFVAMHALQETSHSKSSEVHRPSQLLITLAGMLIPTTLNIMHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZU5</accession>
    <name>A0A367JZU5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000462">
        <property type="protein sequence ID" value="RCH95484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZU5"/>
    <dbReference type="OrthoDB" id="2252158at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="141" mass="16575" checksum="2051DB03352C5D46" modified="2018-11-07" version="1">MPTSSSCTSLVLSPSSSTASLGSHWSTDSKRPRVAELIHLFETGSHPEQRRHSIDTCYHFHSRRYIQQRRFEYIPTLKEWEKRENKRPPIQLVSSQSTPVKRLVTKREIKINDRYSQRKVTSTRDFSWTPQFKGIEALEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K079</accession>
    <name>A0A367K079_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GLK1_5</name>
        <name evidence="14" type="ORF">CU097_009484</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000445">
        <property type="protein sequence ID" value="RCH95652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K079"/>
    <dbReference type="STRING" id="86630.A0A367K079"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="215"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH95652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="475" mass="52823" checksum="0095C183C6CA2B9D" modified="2018-11-07" version="1">MTSREEILAQVEKAFQVTEEQLNHLMVGINEEMKAGLNIDRSIGDYKRSELKMIPSYVIGYPTGYEKGTYLALEISGVDIYVCQVKLKGEGGKLAINQYQYKIPDNLTAGQDIGDLIDYVADCVADFQQRVGAPRHQVYSMAISLGFAVLQTGLDRGIIIALEHGFDFPNAIGCDAVDLFDRRFRAKGLAVKIVAMANDGVCTLLAHAYQHPTTRIGVIHSAGTNCAYYDKMSNIKAFGDNEKDDMIINTEWCNFGAKHLPITEFDKLLDTQSNNPGIHNFEKMTTGMYLGEIVRQVILYLMDQKVLSFDLSSEDDEDEEGCLLSIPYQFDTSYMYVCEIDKDDLEDTRVVLEEMCRIGETTLRDRAIVKKVCEWVGHRAALLLGAGIASVVKYTVEQGIGLDQEKGLAIAISGDVYKDYPLFHPRVCEAIKNLIPENIASKLSVGVVQHSRIVGAAIVAMMAEKMDQRDTVMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K099</accession>
    <name>A0A367K099_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000448">
        <property type="protein sequence ID" value="RCH95623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K099"/>
    <dbReference type="STRING" id="86630.A0A367K099"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="260" mass="29161" checksum="8EAEA5469F5D10E5" modified="2018-11-07" version="1">MFSPAIKKSLTVAAAGAVWASTATTAFAEEKRTKLSIYDEPEPQVVIVESPTKLEEHVYIAQKCANDTLEKGKSHVERWTQKYQQLENDITTSINNTIDKNEEIYPNILYVGVAALAGTIIARNRNVVLRFLTSTTLAVGTSYYLLPKTTTNVYHQLERLERKYPQLQAAHQTVKGTVDDVYKQIDNTVVQLRSAVDENAAKLREQIQQNTQFVKSQVNNTVGATSSEAKDKFEEAKKKVESMYSTRSNPGVEETLKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0C8</accession>
    <name>A0A367K0C8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000450">
        <property type="protein sequence ID" value="RCH95599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0C8"/>
    <dbReference type="STRING" id="86630.A0A367K0C8"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="85"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="311" mass="36358" checksum="EF1612983E806224" modified="2018-11-07" version="1">MNVISKISEAVNVVFYSVSLFGLTGTLQLVQVGSLILSPLSERLMIRINSGLIGTVWKVMQYIFERRKKAHITFSGDHIPFGESALVISNHVSWTDIYLLHSVANRRNMLKNCKYFVKDSIKWLPFFGWGMWLAGFIFVRRNWTQDQAKIIAAFGKIKRLETPAWIINYVEGSRVTSKKLQESQAFSRERGYPVLHNLLLPRIKGFATCVNEFRGSHIKYVYDFTLGYRHKSKLGQNAPSMVRVHTRSLWPEYEFHVHARRFAIEDIPRDEIELGHWLRQLWVEKDEFLSGLHDNWADHIDKQTTWKESSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0F6</accession>
    <name>A0A367K0F6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000440">
        <property type="protein sequence ID" value="RCH95694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0F6"/>
    <dbReference type="OrthoDB" id="2289398at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22428" checksum="000000ED047AF818" modified="2018-11-07" version="1">MGKRRRVEDHIEGVEYNLPVPRSKRRAPSTATFRPIESDFRLLLTEAFRSRLTSIIETYLNQHPESDGASLRNTEEERKMVPPSAFETLDSQHGPYRTGNTAKRLKINALSLYKSYLQESFDSLFSAVKEKLDERTESEADEISTQSAEHQVKSIVMPLGQAIRKDLPAELRSTIMKKLISAVCKYSDFACIFSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0W3</accession>
    <name>A0A367K0W3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Component of the polarisome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPA2_2</name>
        <name evidence="5" type="ORF">CU097_011198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000432">
        <property type="protein sequence ID" value="RCH95785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0W3"/>
    <dbReference type="STRING" id="86630.A0A367K0W3"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="269"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="645" mass="73115" checksum="A5A9A17CEC2F1384" modified="2018-11-07" version="1">MSKNRSTGSTTYSALSASSRQTTSSIQETSAKIYFVELQKYLSFILAKEASEGVPPTRSTARQKLSRLNNLQFHELATDVYDELIRRNSDNHRSFLPVREDFHPRRNQARQKLATLPSSRFRDLASDVYHELSRRYSHIIMTEQTPPVPRPTKAEPQAQPSQSTNIVPVKGMMSVESIDFSDDEQHQQQQPSMPPPPVTENLDSLMADLGNMVKPRTENSTEINKNGSTELENMRYEYELKISAMAKRIKQLELSSEDTRIPNGSDTKYYKANDEYRQLEERYNKLLNEHEEQQQAVKEVKNEIRILIEELKSLSEKNESLRIQKEQADATIQSLTEEAKSWKTKYEGISMELRNYKARSMQFDHNDISKEFFLKPTSNGAIGHQYIIEYQTAIDELMRTSRSTKPSEVLTTMRTIVMACKSITTEVEQYEVKTGLSEADQSSLYEIKKRFSTGLSSLLSAATSFANGMGITPVSLVDAAAITLTMTIVDLVKLLGMRSVASDKTIGPSSTRTATATNDILNPHQLSQFLKKETDQIVASVQNLLSALRSNDKGLFNIITSIINIVSNIINVSEKTLTYHDKYKARGTTILKDLKKCNDKIVNVRDTSFSNSNQVPNTIAKRNLAQESYDIAKYTKELINMLDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1A8</accession>
    <name>A0A367K1A8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SelT/selW/selH selenoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000415">
        <property type="protein sequence ID" value="RCH95966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1A8"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12323" checksum="145FA7CD6CB6EC8E" modified="2018-11-07" version="1">MIMSTTNKPRVSIEYCPKCRWMMRAAWMGQELLTTFENEIGELALIPGDAAVFKVTANGVVVWDRKEEKGFPELKELKQRVRDIIAPNKPLGHSDKKKQEDCKTCPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1K2</accession>
    <name>A0A367K1K2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000409">
        <property type="protein sequence ID" value="RCH96027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1K2"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="32419" checksum="3BE991007A04A96B" modified="2018-11-07" version="1">MLTVKRVIGVASLLAVTLLLLFIQYVFVKENRQPLQLTNNSDEWYYDNPSTLTYPHDRFKAALFTFVKNDTASLTKLRHTIRNIEDQFNKERGYPYIIFTDQELSYEYMELASSLTKATVRFEKVDNVFYGYHPETDQDRAAQTRADMSQIMFGDSEDYRFQSRFMAGTIYRHPIMQELNFGWRFEAGTEYICPIDQDLFQYMYENNKTLSFVIALYEYTETIPTLYETVLDFASQHNEWITSNQDPDSLWKFIQDPFTKNFNGCHLWNNFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1Z9</accession>
    <name>A0A367K1Z9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RAS1_1</name>
        <name evidence="10" type="ORF">CU097_009368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000389">
        <property type="protein sequence ID" value="RCH96234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1Z9"/>
    <dbReference type="STRING" id="86630.A0A367K1Z9"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="23303" checksum="CB43EC6A234229FC" modified="2018-11-07" version="1">MSKSSSILREYKLVIVGEGGVGKSAMTIQFIQSHFIDEYDPTIEDSYRKQCIIDNEGALLDILDTAGQEEYSAMREQYMRIGEGFLLVYSITSFRSFEEVQKLYSQIERVKDIEVFPVILIGNKCDLETDRQVSPQVGKELAKKYGCQFVETSAKQGIRIDDAFYGIVREIRRLNQEKIKNQQFNVDRDKEGLFMDSCGCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5I9</accession>
    <name>A0A367K5I9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DNA helicase rad5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RAD5_2</name>
        <name evidence="17" type="ORF">CU097_014467</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000279">
        <property type="protein sequence ID" value="RCH97425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5I9"/>
    <dbReference type="STRING" id="86630.A0A367K5I9"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="351"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="739"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="826"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH97425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="994" mass="113453" checksum="0C2D40BD606BCF2B" modified="2018-11-07" version="1">MSKRPRDNTLIESLKAILNASTEICESLLDRTNNNIEEAIDLYFSNPPSITTQTKKKKPNRYYLGDLVISGWSLYVGKSPVKEGDRIEISRDRNITDTTNRIVRFAHEGSQLGRLPREIANYVSILLDQNICQFEGTVVWCPNELKIGEDIIITIKCYIMPAAMRINTFLHNYIPKANKNRQRDRAEDVSTLRKTSLVQLFKSLGMRPVRSSIRRMLGGDDTWDMILQSINTRTEPDSLERDELQELNEDEEENKEVSDDQLNTIYERAQVFDAEIKPMEPPDTLTLQLKEYQKRALAWMTAKESLHYEDGDLDMRALHPLWEEYSFPDTTSEHQFFYFNPYTGELSLEFPEANTQERGGILADEMGLGKTIEVLSLIHSDKSRYDYSRIQLENQSKKSPTTLIVCPMSLLAQWRDEIIRASKPNSIRLEVFYGDDRSSLSLNTLCQWDGAAPDVLITTYGVLVGEWSRAQQDASATTLYNIEFWRVVLDEAHQIKNPSTKTSNACKDIFATRRWAVTGTPIQNKLDDLYALVRFLKHEPWANHAFWKTFITLPFEKKDPRALAAVQTVLEPIVLRRTKNMRDSQGLPMVPLPSKTVRIEYLSFSPEEQDIYDAIYNDSKIKFSYFCEAGKLGKNYASIFQLLTRLRQICCHPYLVLQNNQGKTTEVKAEGGRSVLLEDLVAKHATTSQVSSSSVESSNSYRLSVLQNLLKMQQKGSSITEKSGTTAEEGTLPVVPEECPICFESMDSMIAMPCMHMACRPCVMDYFQKKEDQGQPGDCPICRTGPILQNQLLEIAQQQPEEDDKSPKINIRKAVGGFKPSTKINALMKLLRQYDKEKLKTVVFSQFTSFLDIIGEALDYESIHFTRLDGSHNQPQREKVLSTFATSGEKGANVLLISLRAGGVGLNLTCASRVIMMDPWWNFAIESQAIDRVHRLGQQKEVIVTRFIVKGTVEERILEIQDSKHTLVNDLYMSRDETKNRKLDELKLLFSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6B6</accession>
    <name>A0A367K6B6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL43_3</name>
        <name evidence="5" type="ORF">CU097_014702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000247">
        <property type="protein sequence ID" value="RCH97802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6B6"/>
    <dbReference type="STRING" id="86630.A0A367K6B6"/>
    <dbReference type="OrthoDB" id="2185952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="94" mass="10328" checksum="960A42662D89228D" modified="2018-11-07" version="1">MLINHLFNIVGITGKYGTRYGASLRKTVKKMEITQHSKYTCTFCGKDAVKRTAVGIWKCKGCKKVLAGGAYTVSTTAAATVRSTVRRLRELAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K770</accession>
    <name>A0A367K770_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000230">
        <property type="protein sequence ID" value="RCH98015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K770"/>
    <dbReference type="STRING" id="86630.A0A367K770"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="18397" checksum="200C6DF66006243A" modified="2018-11-07" version="1">MTNTSTAASIEVKDYTISQAEINHFKEKYESISDGHGITVEILKELYRVAQVEIPDEQELHAQIRAADSKGHGKVGYDDFLSVMKKQYQINAEEGASKVFQLLDTDNDGLIGGDDLKRGVALFGDNVSAEEIREMLYSADIDGDGLISYEEFLKIMTPCKVNGQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K781</accession>
    <name>A0A367K781_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_006831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000229">
        <property type="protein sequence ID" value="RCH98030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K781"/>
    <dbReference type="STRING" id="86630.A0A367K781"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="565" mass="64159" checksum="9E37F763384A2CB3" modified="2018-11-07" version="1">MDLVNNYGSSDEEDTIKDKPTSSSLVVNAAPETGFDDYTTGSLYTAPTATELTVNVTYDDLNRPILGPQNPFREQQLAIQNIPNGHVEEQAISEMDFRTQFRTFETYGYARDPSLLSGTVETGYVGNLNQASKLGGASIHDRVSKQLRNNKDARKKRESKGKLEEVEGPDAYKGPWAGYEDDYVGVPGGGDYEESEEQQIQEQDQQQQKNITVKNIAQQAETESTIFHGASEHDYLGRTYMAVPQDVDVNLNGEPGTQECFIPKKLIHTWEGHEKGVSSIKFFPKSAHLLLSAGMDNQIKIWDVYHDRSLLRSYHGHTKAVRDITFNNDGTKFLSASYDRNIKLWDTETGKCIRTFSTGRIPYCVAFNPDFNKQHIFLGGFSDKKVVQFDTRTGEITQEYDQHLGAINTITFVDDNRRFITTSDDKTMRAWEFDIPVVIKYIAEPDMYAIPSVTVSPNKKWLACQSLDNQILIYGARDRFRINRRKRFAGHLIAGYACKPGFSPDGRFISSGDSNGNVWFWDWKTCKILKKMKAHDRVVMCTEWHPHETSKVATCSWDGLIKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K804</accession>
    <name>A0A367K804_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000207">
        <property type="protein sequence ID" value="RCH98306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K804"/>
    <dbReference type="OrthoDB" id="2256071at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="20211" checksum="54B1EED40DEA86D2" modified="2018-11-07" version="1">MNELEESKQKKLEKIKIWRDHEKTSVLDWFTAQKKQAWDDYYFARKRARAVLIEEVQTKMQKLRQELSRLNKQYGATNEEIERDLTIAKHPYNGNNTPNLVYSDYESRSTTDTPTEEPEVSLSRTENEPARNHNSQAPYLYSSNSNNRPNDRSDWWPFHSAATGVSSTTATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8E4</accession>
    <name>A0A367K8E4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TP53RK</name>
        <name evidence="17" type="ORF">CU097_014761</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000200">
        <property type="protein sequence ID" value="RCH98399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8E4"/>
    <dbReference type="STRING" id="86630.A0A367K8E4"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH98399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="25456" checksum="BA3725733CCAD53F" modified="2018-11-07" version="1">MIPDNSVLIKQGAEARVFYLPTFLTLPTGCIVKQRFKKTYRHPDLDQQLTAKRVNQEARNLQKCKKAGMDTPTVYFIDIPESTIYMENIIGITVKQRLLDDQHEDYKNIDMDLLAQKIGTSLAKMHSINVVHGDLTTSNLMIRTENDSLVVIDFGLSYTSVLVEDKAVDLYVLERAFSSTHPKTEQMFAKILEHYAASYKQSKAILSKLDEVRLRGRKRSMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8R8</accession>
    <name>A0A367K8R8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">H6PD_2</name>
        <name evidence="9" type="ORF">CU097_012845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="PJQL01000187">
        <property type="protein sequence ID" value="RCH98566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8R8"/>
    <dbReference type="STRING" id="86630.A0A367K8R8"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="251" mass="28123" checksum="3B7900D661007C8B" modified="2018-11-07" version="1">MPTVYSFANGDALSSGLNSFVEKVSREAIADHGYLSVAISGGSLPKILSKELAHNKNVDFSKWHMFWADERCVAHDDADSNFLEVKKSLLDHIPQIPKDNIHPIHEAYAKAKDADKAAEEYEDQLKRFFNNQLPSFDLMLLGMGPDGHCCSLFPGHPLLQEHSRWVAPIVDSPKPPPERITLTFPVVNNSKLVVFVTAGDGKKDMVQKIIEEPQHEFPCQRVKPTHGQVYWFIDAAAAAKLRKESCSDYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAT6</accession>
    <name>A0A367KAT6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRM1_2</name>
        <name evidence="11" type="ORF">CU097_015295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000158">
        <property type="protein sequence ID" value="RCH98951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAT6"/>
    <dbReference type="STRING" id="86630.A0A367KAT6"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="533" mass="60173" checksum="99E740A32656B0B0" modified="2018-11-07" version="1">MARTLQEEYSLAWLHVGTVYIALILGNLFYILSCLSSTINTYRSRVNTMCDTLTSLSSQLYNKPQTLITASMNAIQTVKDGVQMFMLIAITVSKACVIWFVQMYKSTYRCLLGLAIHIVLSVLIKIAGPLQKISQDIASLFTGSSSPLSDWTGALQSVQDNLDRWSSDSDDLIQKVIESPFSMIESQLNQTIRSWEPAPFNLTSFQGPEICDTSELLTALSDMEYKLGYFIKWIIGFVFVLLVVFIFIRIFLIRFQHRRLVELRSLLRTALSKDGEKQVDGDELLRLYDQAASVRLLVETQAIDYKPRHRFIQFMSHPTVLYCLIVGVLGVLLINVLIWALESKSKQLIQAFFDQSSSWITNAMSTWITTVNNQVQNMDGWINQAENDINEKTIGVIKNLALQANNALAGAVQDIQQVIQKVFGGTLLEEPAQGLVKCLVINRIDAVGTGLAWIANASYISLDKLKVSSSFNASTALVHMSNVITDSFYMDDNIDILSGPLKSLLWFYYILLLFWLIVLVIAICFQIKYRYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAX4</accession>
    <name>A0A367KAX4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000128">
        <property type="protein sequence ID" value="RCH99365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAX4"/>
    <dbReference type="OrthoDB" id="2228080at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="204" mass="23757" checksum="8E2B74C419759044" modified="2018-11-07" version="1">MSNEEWQLPMPSGISLNHHSFTIDLLKQFNCETSDISSVEKWNEPLTWTLKRKKHKDYPPPVQNIFTQKKLSKIAINTTISIAPSSQQPSGSIKDIQPPIITQYPPTPLKYSPVEPLMEPMVDTHKKRKTLHRLSVPILKITSALQPQKTEDDMLRRRRSDSDLVYHLEDTRHNNSSFLTKKWNKLIHTCKRGFKKKRHPPIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAY1</accession>
    <name>A0A367KAY1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000127">
        <property type="protein sequence ID" value="RCH99382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAY1"/>
    <dbReference type="STRING" id="86630.A0A367KAY1"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="750" mass="86252" checksum="1A7161629B515580" modified="2018-11-07" version="1">MQPEECQIVESPLSSSFEKKLALNFERFNKVPNYDIVIDEEGANSHSDNEADTIYVNHDMNNEPIIYHQSLYKNNNDDPIHSALFFPLFIMSSDPPSTRESDADRKASWQNINKGPSSPFLSNPIKAISDSKEGHNLKQYEESMMRQQPSTAGFTFDPTQIFQKAPAVQTITDNISQRAEQQQTFASFKPATSPIPSPSSSRPIKTPKRKPAIILTEHKQPPIDIHQDDSNDDDNDDNKPLTVTKEKLSNCIRVAEQEFLAGIYLEIEKNHSISECYKLKSLNLNRQGITALNNLGQCFPYLEKLKISHNELTELHGLPDSLCYLYANNNRLTSIDLNNLTRLQQLYLSYNYLSQLENLSDLKSLRVLDLGHNFIRSYSPLGKLEGIISLSLKSNDIHRLNEFQDFNQCSNLEILDLSFNRIERLESIESLTNLRELNLDHNNVKIVNLNRPMERICKLKLSYNRLKSFDISLFPDIRLLYLDDNQIERIMGAACTKRMDTFSLRDQGKTKVEMNIQHFRGIRKLYLSGSPFKSLHQMFDFYSLEYLELCAADIEELPSQFSKQVPNLGTLYLSMNRIADIRPLKKLKYLKRLVLIDNRLTSLNEVLCVVKQMKRLACLDLRQNPMCTNFYLPLNPPAVKSHSIQNNDHRIDDIPISPYIATTLDNEWAADDEAFVHSLSDHWKTRRAVYRSLFILECPRLINLDHIPIHSTEREQAPRIIQQYSFISQGRSGSSHGSDYIDNSALHYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDV1</accession>
    <name>A0A367KDV1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MET8_4</name>
        <name evidence="8" type="ORF">CU097_009671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000067">
        <property type="protein sequence ID" value="RCI00321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDV1"/>
    <dbReference type="STRING" id="86630.A0A367KDV1"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="6">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="25282" checksum="EAB7CDDEEBA09813" modified="2018-11-07" version="1">MAYSKKYKPIQGGGSLIVAYQIANKKVIFVGGGSVAAQRIVSLKMADIHVTVICPESVYGSDLDHVDMCLTALDDHEESLRIGQLCRERRIPVNVADVPPLCDFYFMSQHRDGPLHLAVSTNGQGPKLVNMIRVKAAKSLRPNMCSVIERMGRLRAKVKEWEPSMKNSGKRMTWVTLLCEKRGLDSIAKLNEVDEEQEAAVFEEFRKHFLIDSVSPVENILSRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDV3</accession>
    <name>A0A367KDV3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000064">
        <property type="protein sequence ID" value="RCI00369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDV3"/>
    <dbReference type="STRING" id="86630.A0A367KDV3"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="384"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="702" mass="81138" checksum="E181A6044D71DB98" modified="2018-11-07" version="1">MISALRSQEDRNKLVMKRRMLKIVKKMLPKLHAEIDENMMKGTYEDLEIIARTPLPSQRRATQSSTANSSVMGRPPELDKVKEKKKRQSSEPYYYNETESEDSDYHEDEYEETFTFAKNVHNPMEILTVPSTWGSKPIDYLTVIGQETDTECSYENRQVKIIGSDEDCVKEALQRFKNLQTIHKRRKRPTTTIACVHLPQDAEFAIYFCPIDRYARKDYVNVLTYKHAPYFVLLPVFKDKNGIFEKPKDRIDIPSLPYATWIPAPEKQAPTPQRFQQTEMSLDERMKMASFKNKFNAPQAGAAPDQRPLWGEKQFVHIPSAQKPPLQRSTPPPQTPPPAQKTPEEDFPALPSAPRKAPPLKSPNRRVMRVVSQKSGHDSVKGLSQLEILRQYNLHNMMTTLGQGLENVHGYKGNIKLSAYLGKILWTSLNKEQQKKIWKYQQLNDILMKEGGVKPMFNGLVTEDVDIITKFRELFPSPNGKHAYFEIHANARNQPVLPYKPVVLYMNQHAVNFTKIVTGTHRVAEIDWVSLNRKYDFQMVLQTEDLTRMDVKPYSTFLKKISISPHCRQITYEDVPDFLEVTDIYLKDTTRHRLHFPFVVEITRVEKLPLIPQTSLGYNINKILGDTGRGKVWYTIEIFYSAHDQLFKSNLDLPVGKFAPWTVEDVLGRQDDLTGPLVEFVRCLLLIIERAETAVSRENRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF36</accession>
    <name>A0A367KF36_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000038">
        <property type="protein sequence ID" value="RCI00826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF36"/>
    <dbReference type="STRING" id="86630.A0A367KF36"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="633"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="801"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1055" mass="120437" checksum="D918FF92EBDDF416" modified="2018-11-07" version="1">MNTKDIICQVRALYPYEPKDPSALSFKANAIIDVFAQLESGWWDGCCEGRRGWFPSNYVEILKQAPTGRRILTDQHIKEQLRLSLHASDMILNKSNAPASSSSSHSNNQSEWILQTTEDGSEQYYYNIRTHEMRHSIPPEGYVTTEEEDDLIPPARPVRAANRMEGSSQLLDDIYDKLPPGWMRKITPQGRYYYCNPETEETTWELENIDPDTGMLIPSQPNSPPSSPSEISFDLKDTPITWSTLSATIAHAIHNLKECIRAGKTTYIQQESAQVVQRIRLLLYVSNCLDKESSVHLKSNKQLRAVHRNLLASVAKLILSAKMTSSAWPSPETLGKLMSEAEEILMSVRHFMTWAQDMRIELKEKAGPTLAIDRPLWKNPIQVNSQHYHRAMLSGQPDAVTAIMVLADNVRGAISSFMESIRDAYSHIHNDQDIKSTLRKLKANAPLLVAQFRNLSNTTSQFMNTVEQVHEDDNLKSVAIMKAKHPIYAAMGSLFVVTQQITNSGMNIVEAEAAYERINEAVQAIENSIENAVDYSQMDEEEIAEEVKTEDEEVKEEEQQEQPKASSSSNPSPVKDVKIAKFFGEDPPPPPPRNPSPTTPSSPSAGAPATNTQGEVPWFLAADIDPNEIALNVEGQVKGGTLHGLVKRLTQHDQFDAKFNTTFLLTYRSFCSTEELFNELFQRYQLQPPEELTAEEREQWSERKLKLIRLRVFNVIKSWLETYYNEEEDRPILLELSQFTDHVISHSMKFGAEQLTRLIKKRMLAEESGQIRKMKLNVRQTEMPPSILPKNMKRIKLLELDPHELARQMTIMDFRLYNRIKPVECLDKNWGKPDTEEGTHIAANVKASIEHSNQVTAWVTDSILSKEEVKKRAAVLKHWIAVADRCRILNNFNTCMAILSAFDNGSIGRLKRTWELINGRSMQILQNIRRLMGANRNFSNYREIIHRVIPPCIPFLGIYLQDLTFIEDGNSNFLKKSNNFINFAKRMKTAEVIQDLQQYQSIHYMLNAVPDIQEFIKTHLQSSRDEEELYNLSLKLEPREQGEDTIARRLKESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGR1</accession>
    <name>A0A367KGR1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="8">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TARBP1_3</name>
        <name evidence="13" type="ORF">CU097_014563</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000011">
        <property type="protein sequence ID" value="RCI01413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KGR1"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056921">
        <property type="entry name" value="TARBP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25050">
        <property type="entry name" value="TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TARBP1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI01413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1332" mass="153856" checksum="641A3BB014FA8E38" modified="2018-11-07" version="1">MLWQRTLQMYGLPATNLLRLEIYGLIARFFDFYFGLDEGKQTPDIRTDLRFEESFFMILQSGLRSNDSLARKYSAYILKRIIDFTEKYPSTIATKSESDWTRFFRWNVDKTKQYSDCWEDWFLLYDIMHESVIHLVDPVLHRFESLLNADNGMDPSWWTLIFYRGFQNETASVKRGLLEYIFSRENPQTLHIMGVEQGFMFGALFKTVDNTSLFQVPTQGALVSPFGEHFRAFIYRLVQALQTEHKVNFLRQLIHHFSHVVSSPAPILYAMEALAEVDRVSAWGPEELKSLRVLVDRHRNFNIPTTKKFLRKLGVAATVRFAHTATLSFSDIAKTVSSLVNEYPINASSQEFKMIRYWLENDVSANKSLDSIRQGLKDRIETYVCELKSEDIPETVLRSQANVLARASVFAVSTNEGHVDEEKLLDLLDAFLIHLTDSSISDVMFSRLLTLLESLWENFEATFDNQFNFTKTVHLDDDALLYILARIEGKYLNKEGPNVVDGDVVDLYLSLTKRILGKESVLELENKTEAIQTYYEKCIDLLKHRSSAVDPNKELSKPFHIQLLRILYQAATDLSYYSLDYDDQALSLVHGLPMKRTQEAIQQRSWGDVIASFIRYKWECIESIILYANAARKSNVTKECFDPVELYEVAIDQLESASEMCGEAIISSFGPLFAFPWEKNVELVSRCVDLAIELMKENINQSKTFPLLIKAFINVIFQPELLSVPELNEENGPIKKALHMVLDTGDLKPFIVAQASKHLHSYWSTFTEDACRSMQQYAPEFSKLAVFGPLRDREDQKLEAAISLKIATSEELEEAEGTAASVFNQNDYLVRVYMNDLLLRLDTNNERHREFANTLLASFLHILENDALYEYMYTNTVEHRLKLRVCCSTILIIDLVSEDKVDTCLETMFEIIRKETVTSVRCYLEWSIVRLLCRFPDRLPLYYQKLSDTSHKPNYVISLLTLSFTLGQCLPESCIEGYFDEIFVRLLPWLITNHFTIRLFAYCGWQHNWKACTKRGHGAMLENNRYLDSIGNFMETYVDCIKFFDKIQAQFYMARFDPIQDFNVEFIFRQMMTEFQVIDNEKIGSKAFVRVNPQRVERCPFENPERRSVYTAADPSELIGTEQPDAMATMDTPSNQSSEDVYQKKIMPWEMMLETDMDLTKNLVKKNRRRNDLIVVASLIDRLPNLAGLCRTCEIFNASLLVVPTLKIKEDIGFTSVSVASERWMPMTEVPESEVAKFLKEKREEGYTICGLEQTTTSATLGEYIFPEKCVLLLGKEKQGVPADLLQMLDVTIEIPQYGITRSLNVHVSGAICIYEYTKQMQWRQQAAINQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGT5</accession>
    <name>A0A367KGT5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGT5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="12043" checksum="0726A4FF8F2E7291" modified="2018-11-07" version="1">MFLETAVPKPILVASGSGLRCEPIFWGRKNCLGDRGTCRLLSCRFEIIPLEGVSVHAPKFCVSFDEFDIFALLYRLGHLPPILRNESHGFIDFSFLHMVFNPDCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH97</accession>
    <name>A0A367KH97_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000003">
        <property type="protein sequence ID" value="RCI01605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH97"/>
    <dbReference type="STRING" id="86630.A0A367KH97"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016793475" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="20617" checksum="119658E3DE1008E3" modified="2018-11-07" version="1">MKLAALLASAAYLASFVSAQTAIVSITSPLANTRVKAGTEVIISWVNPKVPTIPQIVLAKGPATALQPLMTIATNVNANDMKYVWKVPKELPEGNDYAFELGTSPDIAFTGAFTIEGGTGGPLPAQSSSDSSPSANSAPASSSSSSTNSNTNNSGAVATPASVSSTSSQTSQGAGASHASSASQNSSPAQVMVAVGLAAIVAAQHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILC7</accession>
    <name>A0A367ILC7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005132">
        <property type="protein sequence ID" value="RCH78487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILC7"/>
    <dbReference type="STRING" id="86630.A0A367ILC7"/>
    <dbReference type="OrthoDB" id="2287814at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH78487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="170" mass="19789" checksum="5C2823CB50F041B7" modified="2018-11-07" version="1" fragment="single">DQLDAKIKELKEKIKRNERMRDKAYQLRPLLTDKNALSQCENEIKECQKSIDYFTEELLKIESRKDSDTTETDASSHTTHHTSTSNPSVEHPTVKKYSTLDLLTTETLYNKSKVSLKLHELEYKLDVENKVLAGIKTMADVMDKDPSLSDRRRRLELQGQMYESIEKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILF2</accession>
    <name>A0A367ILF2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005131">
        <property type="protein sequence ID" value="RCH78488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILF2"/>
    <dbReference type="STRING" id="86630.A0A367ILF2"/>
    <dbReference type="OrthoDB" id="2408597at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34141:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016603160" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="65" mass="7475" checksum="3E8CCE9C2599D4F1" modified="2018-11-07" version="1" fragment="single">TVRFPLSVPVLSWLLSVDWVPLAVDQEDEKAEANPYPEVTDLFCRLPLSTLFYQLEAFHLGDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILR6</accession>
    <name>A0A367ILR6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005157">
        <property type="protein sequence ID" value="RCH78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILR6"/>
    <dbReference type="OrthoDB" id="2289268at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10227" checksum="B6F17D648DAFF382" modified="2018-11-07" version="1" fragment="single">MDIAADTNPVAAQIVLTLDDDDVQGSTDIIRRRMNKLSTITRQAIFKQFGHTITERHLKNALPDIQSNELQACVIIANFLMPYLPATTDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMZ4</accession>
    <name>A0A367IMZ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004730">
        <property type="protein sequence ID" value="RCH79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMZ4"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="96" mass="10251" checksum="E51BD051D625BC31" modified="2018-11-07" version="1" fragment="single">PCIRQAYTYSTIPKKAAGRFTSNRLIAESTKTSYNEVQRTLVYIGPFADSVKKYKMTASFFGICGIIAVPSLISTGQAPILSVALAGISAVTPALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPI9</accession>
    <name>A0A367IPI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBE2E1</name>
        <name evidence="9" type="ORF">CU097_001726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01004412">
        <property type="protein sequence ID" value="RCH79575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPI9"/>
    <dbReference type="STRING" id="86630.A0A367IPI9"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH79575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="15885" checksum="D1043E5AD137A051" modified="2018-11-07" version="1" fragment="single">IKKELAEISLDPPSNCSAGPKGDNLYEWVSTIAGPADSPYAGGIFFLDVHFPQDYPFKPPKVTFRTRIYHCNINSQGAICLDILKDNWSPALTISKVLLSICSLLTDANPHDPLVGSIAHEYLHNREEHDSTAREWTRRYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQF7</accession>
    <name>A0A367IQF7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004220">
        <property type="protein sequence ID" value="RCH79895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQF7"/>
    <dbReference type="OrthoDB" id="2287310at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8494" checksum="952837DEC5287F31" modified="2018-11-07" version="1" fragment="single">MSTSASEQRIEEITSALKEQVDKIPERQFIPRQLDKLSSESNGKQYNLESSSANLIISKGETVINTLSPREQERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR37</accession>
    <name>A0A367IR37_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_000626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004105">
        <property type="protein sequence ID" value="RCH80089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR37"/>
    <dbReference type="STRING" id="86630.A0A367IR37"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="8">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="10">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="9">
        <location>
            <begin position="254"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH80089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50541" checksum="8E3450D3EBEF7845" modified="2018-11-07" version="1" fragment="single">FAFKYIPTTVVTKPWNACIRAIAKPLERVPKHILHIAYGFFVLAVIVITAFSLPEKPESTRIQRLIALFGLIIFLVVLYITSNNRKAINWNTVFSGMLIQFILALFVFRSSVGHDIFNWASSFAQGYLDKATNGAAFVFGDTAVQSNVFAITVYPALIFFAATVQILYYVNALQWVLQKCATIFMSLFKMSGAEAVVAVASPFLGQSENPLLIKPFLPYLTMSEIHQVMCSGFATISGSVLYGYMTMGISGEALLTSCIMSIPCAITVSKMRYPETETPMTAKTVRVPPSDDRPSNLLHAAGNGAAEGIHIALLMTANLISLLALLYAVNAFLTWAGNFLTIQNLTLQLITGYIFVPIAWLIGIENRDVVAVGQILATKIWANEFVAFQALTTTYKDVLTPRSVLITTYAVCGFANLGSVGMQISVLSTLAPKRNGDIASIAVSAMLCGALCTFISASIAGMLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRY3</accession>
    <name>A0A367IRY3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAPD5</name>
        <name evidence="8" type="ORF">CU097_002867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01003922">
        <property type="protein sequence ID" value="RCH80433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRY3"/>
    <dbReference type="STRING" id="86630.A0A367IRY3"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH80433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="384" mass="44411" checksum="BE225111D6D86901" modified="2018-11-07" version="1">MDAPWSSSKTLSITDSISRLSQEILDFEKYIAPTDHEQRLRLDALNMIQRLIESMFSPMPVVEAFGSFVTSLALPSSDVDIVIRFDKPVMPRNILNRIYREAKRRFIFKRSEFIRAAKTPIITGCLRNGVSVDISVQGNVTSSERTVTWIKEYPELKPLFMVLKQSLSAFRLRNVWTFEPLSAKTAGLCNFGLICLIVSYLQLHKPTDITSTDPEYYGRLLLGLLDYYAHDFDASMHIISVSNEGKYYPMREMNNVLGDYYYESGKLFIINPDEPGRNVTAALQHFDYLQLIFKTASSLLKSRLSKKGSVSILSSIIKVETRYGEKQRKELDDFMVDYIYANMDETMYTRKNDDLRGSKKRRRRNDDDDDTRAEERVGKHIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISX4</accession>
    <name>A0A367ISX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003728">
        <property type="protein sequence ID" value="RCH80800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISX4"/>
    <dbReference type="STRING" id="86630.A0A367ISX4"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28232" checksum="CF40CB7E723D2FCF" modified="2018-11-07" version="1">MLKKLSLHLSHKPHKVDSNKQNESRPPVVANDSFYGKSHYTHHLDTTTHSDSIRPPSLTIDHDPVSPASPSPLTPGQDIESLIQDGITFHERGQLEKATSLFRVAAEKDNPLGMFLYGVSLRHGWGCKKNEHLAFQYLQKAAEHAVEDLTNITNAVNASASRGELVMAIYELGVSFKHGWGCKKNKESAAYFFKIAADLGDPDAQNDIAHCYNQGIGVKKDLYMAAKYYRKADKQGQGIMGNSWIWKPKYDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT03</accession>
    <name>A0A367IT03_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_003973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003717">
        <property type="protein sequence ID" value="RCH80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT03"/>
    <dbReference type="STRING" id="86630.A0A367IT03"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="34458" checksum="F75A8C93A52ECB4E" modified="2018-11-07" version="1" fragment="single">SRLKNEKFDPIDMTVADFDGVTYHISTPETKTVVHISLAWACSRELFSYGAKDILKREYGDYLLDTPEQGFDITLALDLEKMVSTEQDVRDELIRKVSLLKRNLLAAPFERAFAEQEQCEKEGKTECNSELMTVHYREEEAIYVKSNFDRITVIFSTTFKDETDKIFGKVFLQEFVDARRRVPALQNAPQVLYSIREPPMELRHLNLKDSDDISYVTFVLFPNHFTVGDVREETISRIQIFRDYLHYHIKCSKAYMHTRMRARVRDFLKVLNRAKPQVMNTEKKTASGRTFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITN5</accession>
    <name>A0A367ITN5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="13">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_001524</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="13">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="13"/>
    <dbReference type="EMBL" id="PJQL01003633">
        <property type="protein sequence ID" value="RCH80996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITN5"/>
    <dbReference type="STRING" id="86630.A0A367ITN5"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="347"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH80996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="457" mass="52679" checksum="C152E6F972981F12" modified="2018-11-07" version="1">MSVTQTQVAVEEKFPPYAYTETENRQPPMANPNLPPLFDEPTTLYNFTKHVNWFQAILLISTPLLAVYSALHTPLQAKTFYWSILYYFITALGITAGYHRYWAHRSYSCTKLTQIFLCLAGSGAFQGSIQWWSRGHRAHHRWTDSDKDPYAATRGFFFSHIGWMLVNRPKNRIGYADTADLRSDPLVQFQHRYYLYFATTMAFLFPALVAGFGWGDFKGGLVFAGLCRLVFVHHATFCVNSLAHYIGDTPYDDYHTPKNSWITALVTCGEGYHNFHHEFPQDYRNAILWYQYDPTKWFIKTLNLFGLTYGLKTFPSNEIEKGRVQMMEKKVDALKSKLKFGPQLKELPVYSLEEVHDMVATHNKRWVILDGMIYDVENFDHPGGCKYLEFGIGKDMTKSFNGGIYNHSNAARNLLSSMRVGVLQDSKVHLYGSSVNLQAKATEYDSTFEPNRKNKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITU9</accession>
    <name>A0A367ITU9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DDX20_1</name>
        <name evidence="9" type="ORF">CU097_001065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01003585">
        <property type="protein sequence ID" value="RCH81097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITU9"/>
    <dbReference type="STRING" id="86630.A0A367ITU9"/>
    <dbReference type="OrthoDB" id="434041at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH81097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="188" mass="21753" checksum="BB9D7E90C35595CB" modified="2018-11-07" version="1" fragment="single">MPRSIELAEWLSEMGWKSAHISSGLSQHERLAVMDKMRQFKLRVLVCSDLIARGIDIDRVNLVINLDLPWEVETYLHRVGRTGRYGTSGIAINLIGPEDMPHFEEIKRKGIQELTAEEQAALKEHESVNIQVKPFRSKRISKERSVETKKAKTRERPKQTLLPTSKDKSRTVKSQSYWQPFIPPDLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU38</accession>
    <name>A0A367IU38_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_000125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003543">
        <property type="protein sequence ID" value="RCH81187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU38"/>
    <dbReference type="STRING" id="86630.A0A367IU38"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH81187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="354" mass="39953" checksum="0BC590339D83664D" modified="2018-11-07" version="1" fragment="single">DMWHVYNLISKGDMIKATTIRRLQSESSTGSSTSQRVRLTLTITVENVDFDPVVGLLRINGRVSSENTFVKMGSYHTIDLELNRNFTLFKSEWDTIALERVDDACDVTKQADVAAVVCQEGLANLCFLTQHMTVVRQRIETPIPRKRKGSVANHEKGLEKFYEQIYQAILRHVHFDIVKAIIIASPGFVKDQVYNYIFDQAVKTGNKTVLESKSKFILIHCSNGHKHALTEIMQDPTLQVKLADTKAAREVQALDKFYEMMNMDPDRAFYGFDHVSKANERGAVGTLLVTDELFRSADIDTRKKYVALVEQVRAQNGSVYVFSSMHASGEQLNQLTGVAAILNFPVPDIDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV90</accession>
    <name>A0A367IV90_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent Lon protease pim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PIM1_1</name>
        <name evidence="9" type="ORF">CU097_000403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003359">
        <property type="protein sequence ID" value="RCH81613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV90"/>
    <dbReference type="STRING" id="86630.A0A367IV90"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="8">
        <location>
            <begin position="101"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH81613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="576" mass="64638" checksum="F4275BCD5B3CCC98" modified="2018-11-07" version="1" fragment="single">DAIDTLIKNYCRESGVRNLKKHIDKVFRKAALKVVQLADEKQSTDNNKEEAEKTQDEVKESKEEPQKPLTVPKDVKLEINSENLKDYVGPQVFLSERLYEQTPPGVVMGLAWTSMGGSSLYIESVLESSLTPKSTPHLSKTGQLGDVMKESTSIAYTYAKSLLATHFPKNKFFDKAKVHLHCPAGAVPKDGPSAGVTMTTSLLSLALNKPVPSNIAMTGELTVTGKVLKIGGLKEKTIAAKRSKVNTILFPKDNQADWDELPEHIKEGMTGIPCDTYQDVYNVVFPNVTKEEAENVIDGSNVTDASYFMKLSLKEYQWKLSLEDYLYLVLGSTSNWTAISKTIESVYKIQQPPIPIDPVTSPLSTIDDLMRHKIDRDAAEVKLRTLQLLKNEKKFAKTLGLKWERSLGYGEAKTAARESDHYLVCQDLIKLMDDVLGIHTVGRTIHFYVLVLPATVTYVMYLLTEIKMLCNETNTFYPNSNTPGHLPQSSCISKSCGKTYSVIIMVEMLGRIFEEANLNSSNYWKLLSAFYHHPRKTKVSNISIFTPRLMQMPFLHLKPTWTKNDVMKAPRALCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW31</accession>
    <name>A0A367IW31_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL28_3</name>
        <name evidence="7" type="ORF">CU097_003690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003261">
        <property type="protein sequence ID" value="RCH81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW31"/>
    <dbReference type="STRING" id="86630.A0A367IW31"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="71"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="144" mass="16202" checksum="2995C065E9090159" modified="2018-11-07" version="1" fragment="single">PTRLHHNRKKRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRHFHLKKNPLWRPVINLDKIWTLAGEGVREKYKNTEKVPVIDTLQHGYAKVLAKGTISQPVIVRTRYVSALAEKKIKEAGGVVELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWD1</accession>
    <name>A0A367IWD1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003207">
        <property type="protein sequence ID" value="RCH81962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWD1"/>
    <dbReference type="STRING" id="86630.A0A367IWD1"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="505" mass="57566" checksum="F02C8A95845A0ACF" modified="2018-11-07" version="1" fragment="single">TPFERLARLNKHRNVEVTSIARLPDHVSSNSNKQPKKKKVKLSKELACQLQIILTDEDNDSSYEQVFEHWEEVMSINSALSADNTDVDDIRLKRLFSIGNSNSKKDKIEEQFVENRQYHVLRIFAGNINVGAMFATVAVTPDMNADQLLKLALQKFHIPLLTDKSNTIEYYLTVKSMDSDELTLLPQDKPLAIFESLSDHLTTPMPSLTSIKKLSIEQPTIKVTRVGVSKARQRAKAHFGEDSVIRFSLHKRIKRTIDGQVYVKISYYVDNDNIKRGSVLRKSSLLRKDVHPKKFLKKERIEKLVATSSLTRISDLIITALEKFHLKGQDYNMYYMTVLINGRSEKTLPMDRSLVDILNDSELIPKGTTEKSFILHKKEPTQSAGVTDLSYDNNRRSVVRKLLKQQDSNHKYSLSSTETVIKKLDEAIQSLEHDKKQISPKVAPTRSNSLSAYYDKKHSNDFKRSLPTRSSSLKLSGDAFDSLHDSDLSNMDDLELELQRIATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWH1</accession>
    <name>A0A367IWH1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003178">
        <property type="protein sequence ID" value="RCH82027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWH1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="12273" checksum="11F12EE2F936A71B" modified="2018-11-07" version="1" fragment="single">NLDIEFIEVPKDRLKRQLFFMEQSLNMARGGLNHHSGSVDQVSAKFKTIIPASFEYQPVPIDQRKYTQLLTKDSNLLDDIEQLINCIIKFNHCSVLVTSFDFFAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWI1</accession>
    <name>A0A367IWI1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003203">
        <property type="protein sequence ID" value="RCH81969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWI1"/>
    <dbReference type="STRING" id="86630.A0A367IWI1"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="398" mass="45207" checksum="A227F274407236B3" modified="2018-11-07" version="1">MPFSRPFSQYIRHFSTTTKLGYKNYYLTKGLNGSLLRINLSTPNKLLGIYTSRGTRSANEDNYSAVSLELANTPQLLHMTKEANRAYFGIFDGHGGPVVSEWLAHRLHDRIESVTLNDFAKVLTFLRAYRGYFRRFPIPKVLETLVDNDGRPKEGVDIHDLTLEQRLTLAFLEADMQCLKQLRGEFDDSHEDHEGSTGSIAVIEPRDKKAFWESEEYDIVIGHVGDTRILLCDSSSGEVVPLTTGDHHPGNPAEIERLRKYAGFVTTDSWGDERIMGMLATSRAFGDAKLKKYGVSSEPDIVRYRIRQKNPAAFMVLVTDGITSVLSDQEVVDIVKQHNEPARAARKIVDTADELHSEDNITAMVVRLKDWGKRMHDHTSDLRVYRLESSTMSRRQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXC3</accession>
    <name>A0A367IXC3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Breast cancer 2, early onset</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BRCA2</name>
        <name evidence="3" type="ORF">CU097_004981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003086">
        <property type="protein sequence ID" value="RCH82259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXC3"/>
    <dbReference type="STRING" id="86630.A0A367IXC3"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="1">
        <location>
            <begin position="133"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="569" mass="65395" checksum="2CB1D63D4D33B068" modified="2018-11-07" version="1" fragment="single">THRTYGSTLFDLTVPKERKKLSSLGKPSRYTRQELLSKKIPPEIIDMTSTTSVNYRFDNWGPKEAQKEILDAGALPHRVSLGWIENHYRWIVWKLACQIRSYPDVFMKDWKPETVLHQLLYRYEREVNQGHRPVLKKILEQDDIAAKHMVLAISDIIGVKAPAYYNTSSKYQLHLTDGWYQVSACIDVRMERAIVKGRLKIGHKLSICGAQLVGSRTTQSGLDDENAGRMLLLSANGCLPAAWDTRLGYHPKKYIIRSLPTIFDDGGMVTALDIIVCRKFPMLYTETLPNGKMVTRTAREEEEIRCGYGDMFDPTLLIPNFSGEGRSNVSETRPSPEERRVSGYFKIRICDYCAYSKYPQEEWATLLLQNANELNHMDITEGSRYKIFFVVPYHPKNKRYPGHYFKTTRMTRWEPAVVKHESPYYVPRCITSCSNIRQQDSSLDFNIAVVIIQSGPPKLEQINERKLWRQELYVTDQSQAICRIDLRLPIQLSSNLKGQVIGLANMRFELYDPKYDITCLKTTDESELFTKGSPSTDYMAKGIQALKSWIQSNTDSVAAVTERVQSIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXD8</accession>
    <name>A0A367IXD8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003057">
        <property type="protein sequence ID" value="RCH82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXD8"/>
    <dbReference type="STRING" id="86630.A0A367IXD8"/>
    <dbReference type="OrthoDB" id="3853970at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="84"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23948" checksum="2A5BE6614CD06488" modified="2018-11-07" version="1">MPRYYVPDRSKRLNKNFTLVQKAQIIDYMEKTEGITQVAVTKWAQKQFGLVAPPTQSTINKLWKFRHKYDVKAILEGSLCGGVDRKTLRKSKYPELEKLLIDDIIDCQKQNVPLSGNRIKQMGENICRFDLKLDPESPNFPSFSNGWFERFKKRHGLTVDMVGGEPSYVVSQRLHSLDTAHSINQDDQLESSEGKPFFFIYPYVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY78</accession>
    <name>A0A367IY78_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002954">
        <property type="protein sequence ID" value="RCH82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY78"/>
    <dbReference type="STRING" id="86630.A0A367IY78"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="423" mass="47717" checksum="C876C04A76D2790C" modified="2018-11-07" version="1">MLQTQSDSSTILLEAFQPYKMPSVFSHQTSADHVDGHHSRFQTRCLGSCHIKLRSVTFPTCTFYELTESEISEISSSYKEEMTDESTALLPPKKRKRTKVIRYDLIFTVSNTSQIPMEQQTLYLFPREAMTECLTESAPHKILYSFYQDGQDIEHEEYTHDTRQDTIISILMSSVPQDLYLAMKQMVASYELMCQSMMDLMRLHYEKAAQQKMEVALPDKRSSKIVTDHWSSAEDDWDKDEDMAAEEEEEDTFIKPTKRTSTSKASIAKTSPIKKCLYCGCKTTPMWRRGPQGAGTLCNACGVKWKHGKILSDKPPNGDTVPTTERRRKSSIAGSSKKTNKKKQSNAHEEANNLPITWESTTSSDSSPLDSFSCSPNSSPSLATSLMDKRKPLIPYDSQALSVYVGENAIEAAAVLTLLKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYF2</accession>
    <name>A0A367IYF2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002920">
        <property type="protein sequence ID" value="RCH82717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYF2"/>
    <dbReference type="STRING" id="86630.A0A367IYF2"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="540" mass="63304" checksum="30F7B26E463580E1" modified="2018-11-07" version="1" fragment="single">KQSTPEVEKLVSKFFKEDGHQIRMKKLHWKQTPLPETVQVSPVLNKLRQLALETKQKEQEEEEESTFKIDLAENEKIEKVRKENMFGEEVTESEMDIIQKRVALQQRQFQEFEKREYKRKSKKIKGVYDHLTDEEISDMLVDCGHDEEEVIVRLTQPNYLLDIRRTIATKHAPEVEVSRNAMSEEQLTAYKQLLKKRSETLKKTTNDTAKKQYRMCGRLSLDEAIRQAQDNQDKLDKAFEGWSQARIRAYSMINENPNSYYYRFNAPGEVQRKGQWSAEERKLFFKRLKEVGANGQWGIFSMTIPGRVGYQCSNFYRLLVETNEIQDPNYVLDEKGKAHYLFDKKTADGNVEKTFRTHNKHGTGRGASSSSPTSSSSTTRKRARATPVVADKKKKKKRRTRNWGSDDDDDDEDDFEDYNDDSGTFTMSMRTTRRTRNQEPIQDISNENEGMEEEEEEEEEENQYDNPLPGFLDPITLEEVVRPAISKYGHVMGYDSWVRCLTNWEGKKNICPLTKKPLTKRDLVILTYENIEEYRDKIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYU9</accession>
    <name>A0A367IYU9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_004836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002865">
        <property type="protein sequence ID" value="RCH82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYU9"/>
    <dbReference type="STRING" id="86630.A0A367IYU9"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="506"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69197" checksum="E8C4B4EA13985976" modified="2018-11-07" version="1">MTINIQQQQQQQQQQQTEKEEIWSTILSNVASSRMVPTKRVLVLGDPATGKSTLIHFLKNDPGPQVVQADNDDVPTSFGVNNNYVPLPVENLDDDTRSTLALGYNMIDVQDEENEAIARLGVYQLGLSASEYLPLLKFALSTDTLADSCVIILLDWTRPWSFLESLQRWIHVVEHRINEICKDGSAGETWSRGKAIVDELREKVEHYLQTYAEPVTTNPLNVTTSTSTGSVPSTPNTTTSTNFPTATASATAPLVTTTTSADQVTLPLSQGTLTNNLGIPIIVVCTKSDATNMLDQTMDYKDEHFDFIQQMLRCICMKYGAALFYTSTLQPYTFHNLRQYILHRLLSTLTKPYPFNMKAQVIERDVVLVPSGWDSWGKLRVLREGFDCEAVNQGWDTDMDAVTDRQQPGAHGARGIYEEVISDPLAKDQPLHTMPPPVTCEDEQAFLDRHYETLKHVSELPSRKGTGATTTRPGVVGPIGVSEIDLMRPGDGNKLRDVSMDKPAKLSTSPILSTAASGSSNGAVNLTSETSGSSISPSAAATSTTSSLSPVDAANGTGQPGTPGGPSHEVLANFFQSLLSKKASTGGSSPTSLLGARDGDQLANNTAPSGTGRRPTVSRKDVHKELDRMRQFISKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ77</accession>
    <name>A0A367IZ77_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002819">
        <property type="protein sequence ID" value="RCH82984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ77"/>
    <dbReference type="OrthoDB" id="2249328at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="109" mass="12393" checksum="EA3DC20F60D130EE" modified="2018-11-07" version="1" fragment="single">MCELVSDSEEAISCLENISYDAINEKFVFPDKKGDYDNDKTVIKLKEITSLPSKELTESCKTLLTKLTNQPASSLVMRKTIRSYETEIAEQFDLATNYDTNFVEILSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1U6</accession>
    <name>A0A367J1U6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DEG7_1</name>
        <name evidence="4" type="ORF">CU097_006792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002586">
        <property type="protein sequence ID" value="RCH83681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1U6"/>
    <dbReference type="STRING" id="86630.A0A367J1U6"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN C1685.05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ-like" evidence="3">
        <location>
            <begin position="420"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="513" mass="55903" checksum="40471465F6270D98" modified="2018-11-07" version="1">MDDIQHPLVMSSTPPLRGPVDSPAPAAADEMATNLTAHRDSMSEATNKFEQQPSASAAFRGRSKSIALGTYAWTSKPPRPPVDYFSCSTASGVPYKARSWEPTLERAIKAIVSIKASHVRSFDTETSGGYTATGFIVDAARGIILTNRHVVSPAPIVAQAVLTNYEEVDLQPVYRDPVHDFGFMKFDPSRVKFMELEEIKLSPERAKVGLDIRVVGNDAGEKLSILAGTLARLDRRAPEYGIGEYNDFNTFYLQAASGTSGGSSGSPVLDIDGHAVALNAGGASKASSSYYLPLDRVVRALGYIQQGLQVPRGTLQTEFEYLPYNEVRRLGLKASVEEKFRHKFPEETGMLVVRSLLPKGPADGMLVPGDIIVGCNGKMIPHFIGLFSILDEKVNQEVTLTISRGKKVQDVKVTVQDLHSITPNRFVEIGGGIVHELSYQLAKSYSQPVGGVYVATSGHMLASASAWRKSIIVSVNNVPTPNLDAFIDVMKTLPDGARVPIRYRLVYNQERDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J295</accession>
    <name>A0A367J295_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002540">
        <property type="protein sequence ID" value="RCH83841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J295"/>
    <dbReference type="STRING" id="86630.A0A367J295"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35824" checksum="98454F5BD4B71C25" modified="2018-11-07" version="1">MPLADTYRNKEKGSFGVLNFRDLGISTADNAENKKYIKEGLIFRSATLDNMSQEEVNEFIKAHKIKTILDLRTGIEGKGGLPIDKSFPTSALDNLKPTAMLKEDIEPRAMIKTEVGSVGSTLRKKYKIDFAGKNFQRYCVFASCPLSLKLYVILLMIFCQRQKAAYVIGKEVLSKMGVKQMYKEFAVYCQEEIREALMVFTDPRNYPIEIHCTQGKDRTGMIAAFVLCIARVPEDIIVNDYAKTQKGLAPVYKEMLEDVRRAGLSDDFAEAPPQFMRELLDFLKQKYGSIDNYLDAIGFGEELRERVRKVICLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2I1</accession>
    <name>A0A367J2I1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division control protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_002768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002452">
        <property type="protein sequence ID" value="RCH84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2I1"/>
    <dbReference type="STRING" id="86630.A0A367J2I1"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="69852" checksum="B5FB8C33754973DF" modified="2018-11-07" version="1">MVRITANLYEEAYDYIRQDSAHGNCVMLVAADVDSLCAALMLQNLLKKDMIAHKLVPVSGYRDLERAKEQIIEKDEDLVSIIMINCGGLIDVKEFFDIESYTKIYVFDSHRPLKLENIHHNNINVCVFDDDRETEKLEKVLEAFESLTYNSEDDSENMDSDSSDELLENTRSKRRRLDEDQDLSRSARIKKRAQSNLLMNYYTQGAYHANSTAGIVYDLATKLSKTDNDMLWLAIIGVTSQYLHEKIDTTEYIRSARVFRDDTARFNISTDEEMAVINNEGEIRIEDEYRFMFFRHWSLYESMYYSSYVVSKLGLWNPEGDKNLNRLLAQMGFRLEQCKQIYTHMDVDLKDRLRTKIEEISPRFGLTELCYPSFTRGYDRKCVLSAADVVYAISALLETSPTTAVHFGAEGTWTENRDWRDMLANDATDDATNEKRRWWVKNFYKAYDALGKQSSEMVLHGIRICMETQQAIARQVFTAISKRLIKKHNNCWIMVVDGGPDLPVFGHQLTLFRMGLFALDILRTTSARLKPLIVTSLDEVHNVYIFTSMVAAPAFGETRRNKFPLVFQKLEEKGLFVIDSFDLSSFELKRDTFVNAIKEIKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2R1</accession>
    <name>A0A367J2R1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome activator Blm10 middle HEAT repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002454">
        <property type="protein sequence ID" value="RCH84129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2R1"/>
    <dbReference type="STRING" id="86630.A0A367J2R1"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="530" mass="60582" checksum="DD273CD7D164AD39" modified="2018-11-07" version="1">MHAHETWGQSGDPACLDIQWHVPSEAEKDFALEYLFHCWTPTVERLSEIIKTAPEVNTHEQSNELCRLLAVMRNCLMGSATMVADDGLDEEEMIEIEPDDMNCDDDDDEDHQQYIAKRLEVGYVFTDPQDPRTKQARQFRKSAGELIHALAGFFKTKREDDVESIKIWIKIARAYLSERGAEKSQFERSKAGYSYAKNLVKIPVCKKEYPRNILIRRAYNHHLLRLRLNAMGRLRTPHHDAILYDLLDFSLSSYADIRKPSQVALSATARCFRGAKSLVLPTLLDALQPGTTADRMKGALYLFTHKSMLLPCLRDWKFIPGFIMSICHAQHQDKPTIQELIRKVFMEYISNVHSLSFRVLTPRDITSILESIYSITDESKVAQLEAKVNSRSMFQVSAYTGLIDHLLGFLQDSRVHWRFATMAANFIEVLLRADVKPTAALARFANEATLSELPTMRRIGVSTTTQLLLYIKQRTLASGNPDLLITKKALRNPLKIEIQVPEGEHNLSQQLLQASFEPIDVNKRYVVYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J353</accession>
    <name>A0A367J353_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POLR2F_2</name>
        <name evidence="7" type="ORF">CU097_002682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002410">
        <property type="protein sequence ID" value="RCH84279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J353"/>
    <dbReference type="STRING" id="86630.A0A367J353"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF8">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES II, IV AND V SUBUNIT 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="18488" checksum="D6136C44B478963A" modified="2018-11-07" version="1">MDYDDDDVQDYQDYEPFVEEEPYDELPVEEPALYDEELQTTTNNGDIPTEPMTDRIDILNDVMSGGNIRQREQLPDPNERTERLTTPYMTKYERARVLGTRALQISLNAPVMVELNGETDALAIANRELREKRLPLTIRRYMPDGTYEDWKVRDLIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5J6</accession>
    <name>A0A367J5J6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002158">
        <property type="protein sequence ID" value="RCH85203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5J6"/>
    <dbReference type="STRING" id="86630.A0A367J5J6"/>
    <dbReference type="OrthoDB" id="2283674at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="23199" checksum="9E9D7343092EEEF2" modified="2018-11-07" version="1">MTTFFYEDGQENLFNEHGEKVYDPMEDFLTQIDDPNIVLETITNRETYLSAKRPEKATGEPSVTKPLKSNEAGFHINMRLNWARPKSGKKAIVKQPQTRAPTHTIIGAIHSSSIIHSKPMIRKIESKGYRVMYLPPYSPELNSIEQFWAIVKGKMKCDRLMNEENLCSRITDACNDILISDLNGFCNHSKRQIVNCYNKTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J645</accession>
    <name>A0A367J645_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002117">
        <property type="protein sequence ID" value="RCH85365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J645"/>
    <dbReference type="STRING" id="86630.A0A367J645"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22785">
        <property type="entry name" value="DPBB_MltA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016702496" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="36596" checksum="8CBD8F6E84A9D808" modified="2018-11-07" version="1">MQLKIISLATLGLLFLTSAKFGVQAADETDLVDGQQLSDSYLSAFASDEDSDDLDFELSDEEIHTLTKRADSCAKYHTVVGSDTCISISKKYDVSLNSFYSWNPQVNKSCTNLINGKKYCVKKSSSSSSSSTKKAAKKKSSKKKSSSKKETRKKIQSQSAFTYYWIAQPNDYKGGKKVAVKTCSGQTIGSVSEDYADALVMEGTGVVGSKIVNLGGCTCKDFKCFEMVNRKSDPYGLTSYGTPLRPYVTIASNDIKKGTKIYVPALVGWKIPGSKKTHNGCLLVDDQSWSFKGKHIDFYVYAMDNYQTLDKAHHINKVDIYEGGSCKLLNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J693</accession>
    <name>A0A367J693_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002104">
        <property type="protein sequence ID" value="RCH85415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J693"/>
    <dbReference type="STRING" id="86630.A0A367J693"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="791" mass="89526" checksum="D15E1A2FF14D286F" modified="2018-11-07" version="1">MSDSAKIDKQNQGAACFRCRGFRHACDKNKPSCSRCARRGITCVYPEAAPTLKKLQKATETLGDRIKKFGDRIKAGEMAPLFNIQSAQNDIGSPAYSSSGSSVFSVYSEEEDRPRIKIRRGAKVASTSNFSVYPCTKCFKDLQQCDLLLPRCTRCEANDFECGYKKTEPKANHVSQVLTTMNKVMDQWQDSIDRMAKDFAQKTRDFSVKANNSLKIKSAQTSWKITATQKGISVESNVNSFNDFSALVDQFKRSLFISPKDKHQNNNTNSKQDNRNTDVSSVIDSNLELDDASSIHTTSGFAIWSQWSHPTHALPKDYPIDISQELTDNLVELYCQTPCCSSIRLPIIDTAEFLARYKSSDPTKRPATVLVYAICAMAARNAFQLHVWTKRSSFEAPQYNMGKALSVAYCLRGRELLSECFDEPTLEHCQAAFLLSYCNYQNGFPGVIYIYEWIAFNMAQELGLYQPNRQLSRHEAMLIWCIYYCNAWYRTLQRAENNSSSGISQCKPSCPVPDPLPKPESTGNTSSQQHDQAMVEYYVWNSWVYLIHLQILREESMVRLVAYQQNKATDTTLVQDLIKMQDALRTLRQNLPSEWQKEMASTSCYSPLSVHSDTSNSQTEESGRYCIDLPSFSRYCINLVSLHHSINEIILSQVFVPMDRVPCTSISIQNLQTSLNAANNITQIFETMVQQKEGCHIPLIGFLFANIIYRKLLSYTADDIYYDTGKIGLLRSVEISKASISYIYDFELSRNLIHLMEQDVQYALSKSRTSTETSPSSIPSPTNYMSISPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7F5</accession>
    <name>A0A367J7F5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LrgB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002003">
        <property type="protein sequence ID" value="RCH85840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7F5"/>
    <dbReference type="OrthoDB" id="2502820at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60898" checksum="F09CE496472A3D39" modified="2018-11-07" version="1" fragment="single">QVPAYIHNLPRIRQHLVRWTLNILYFVIGLLFNWAVSAVLRQMPHMHQFPSNVAGMIVVFFLLICAHAILPTYTDKFVQLIDPYSSFALRSMNIMFVPAVVEMVQNSPTPGPEVGRMICVFMVGYFIGFIITTFLVRVSRFLIFYLFDFGKEASMSNLLSGEKTEMHTNRVLKEESVAIDIPEAIRQEANELVIVPSNDMRNLSGDAISSNTVTDRSSYLDNHVHSHGCCCSNSSAQTYIAPSKHRHGPLHSFAVWCMKESNFDDLSFFLMFCFCAFIFLPLPENNPAMPFFRLFLYLSMTVLLYSASCRLPPKFRIIFHPIIVTSAAVMAGIAYFERVKGFDILHGVGLYKGGITFISLVEKTHVDWPGAGDILAMTMDVSIISLAFNVYKNRPSLARQWIVVIISIAPVAFLVMFITPMFAHAIGCTPDNSLVWSSRSVTTAIGIVISRVLGANQSVVTCIIVFTGIMGPIFGPILFKITRVKEDDYMTIGITMGSHSHGVGTAYLISKNPKASGMSSIAFAIFGTLGVVVASIPALSDTIKRLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7H8</accession>
    <name>A0A367J7H8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001983">
        <property type="protein sequence ID" value="RCH85922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7H8"/>
    <dbReference type="STRING" id="86630.A0A367J7H8"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64678" checksum="40C90F9ABA16771C" modified="2018-11-07" version="1">MGKLRKRKQTKADNRELPEDIMADSAAIIFKEKRPFWSRKRFNFIVGLSVGLLAMYAASTTPVAQNHINSLQDYLLLQLADIDLPSILPATEIVDEFLGNFTNLIMPKPATEISFMPALEYKEKLNLKPHFPVVMIPGIVSSGLESWGTSERSRKYFRKRLWGTMAMIRSVLLDKESWTEHIMLDPETGLDPPGYKIRAVHGVEAADYFITGYWVWAKVIENLATVGYDTNNMHFASYDWRLSFSNLEVRDSYFTKLKNTIELSKKQTGLKVVVITHSMGGTMFPYFLKWVESKDHGQGGSTWVNDHVETFVNIAAPLMGVPKAVTSLLSGETRDTMALGSFGAYVLEKFFSRRERAKLMRSWMGGASMLPKGGEAIWGTKDSAPDDDEDEIYQSFGNMISFVPKPEGFNENSTDIPSSSRDPLIRNYTVDESLELLIKSTDVNFGKHLYANYSFGITTSPKQLKLNDHDPTKWSNPLESRLPNAPNMKIYCFYGIDVPTERSYYYAVMDDHEDHDCTYPNNTTACTANQTAPKATVTETVSAPHPARTPLLHIDATVSNPVQRIETGIRFSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA73</accession>
    <name>A0A367JA73_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001793">
        <property type="protein sequence ID" value="RCH86795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA73"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="18420" checksum="B19E7AA18946D967" modified="2018-11-07" version="1">MEMVIQNLTYHPSSWNCSTNKFAIRFQTKEVENKEDRYKHRYAAEVASEPSEELDSINTNGDDITALFENAAKKALGLPQSHKYLEEQPEEDKHLAISLQKLLERYLIQQSFNAQPQDLDMETTTTDSCRVHEVTHEDVRCLGTVQYQTTLGIEQINSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBP1</accession>
    <name>A0A367JBP1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001676">
        <property type="protein sequence ID" value="RCH87348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBP1"/>
    <dbReference type="STRING" id="86630.A0A367JBP1"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH87348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="391" mass="46128" checksum="790393DE1FAA65D5" modified="2018-11-07" version="1">MELKIIQDTPEPVQETLCEICEKQFSKYVCPRCNLRYCSLTCYKDMRHADCTESFYKQSVTEEIKSRDIDKESKNKMLEMLKRLEEEKAEEDVLEDDEYDELLEKFNDLDIDNADPELIWNMLSEKERQEFRSMVSKLDDTWHRFDLPDYIPWWMIIQQSRIQDMTESTSDDHRIPQLPDNLPDFNKMTQPSTRGSPHLIWNMIHILATYSYLMRHSMGELLEDIQDTVHVIETVSAEILFSTAASCPFGSIHEVIDDIVERILRFQEQSSPAKRRMAAVTARYDLKILIIHDLLKLVPERKRAMFDFWHALDQISKKRKKRSVGLAVRKLYFYWAAACAFEDMELVLASLRSILSKIEIEKTNFEQDREAAQRAIREYQKAGSTAKIQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBR7</accession>
    <name>A0A367JBR7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001675">
        <property type="protein sequence ID" value="RCH87356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBR7"/>
    <dbReference type="STRING" id="86630.A0A367JBR7"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="337"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="609"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="690" mass="78605" checksum="A0064423B6B1CC41" modified="2018-11-07" version="1">MSPKRPTIQQQKPRNQLTSDCKWSTLFHDNSNGNDNTSQELSNDTRDTPSGQGLDHSWIWNNPGEDISQPMDPVKHPMYSNINNSATDLLPPSQPEFHRSSSLFSLHQGLLTSGDGNFFNDVNSNPELATKDTMSRMNAFQLSPSFAHARARSIPPLHRAASFSYDNTNEAYLTNFLTDNSDARSTHPMRQFHPSEGYPAYKPSFGLSNSPLPAASHGKRSESWHEDDTLSLASLKLQDNGPLSSPVSYDPFQLTKEDMGQERKLRLMEMQQKTLLLKHQQQQLLLAQQLLLQQQQQTNARTFNSSNTSSSSSSSSNRQQRNHYPKAAAAQDMAFNMRSPLLEEFRNSKQKKYELRDLAGHIVEFSGDQHGSRFIQQKLETASSDEKEMVFQEVLPNALQLMTDVFGNYVLQKFFEHGNQVHKTILAKQMEGHVLSLSLQMYGCRVVQKALEYVLTEQQAALVKELDGCVLKCIKDQNGNHVIQKAIERVPAQHIQFIIEAFHGQVYQLATHPYGCRVIQRMFEHCTEEQTKSILKELHGFTNALIQDQYGNYVIQHILERGKDQDKTKIMKKISGRILSLSKHKFASNVVEKCFEYGTEVDKQSFIDEITEASPDGLCPLVIMMKDQYANYVVQRMLDVVNDKQRKVLIEKIRPHLSSLKKYTYGKHLIQKVERLVTMQEGNADDTQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCI7</accession>
    <name>A0A367JCI7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001614">
        <property type="protein sequence ID" value="RCH87654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCI7"/>
    <dbReference type="STRING" id="86630.A0A367JCI7"/>
    <dbReference type="OrthoDB" id="250548at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019351">
        <property type="entry name" value="DUF2039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876:SF5">
        <property type="entry name" value="CHROMOSOME 9 OPEN READING FRAME 85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876">
        <property type="entry name" value="ZGC:101016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10217">
        <property type="entry name" value="DUF2039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15895" checksum="3340D2340A24EE30" modified="2018-11-07" version="1">MSIYESKTSSRKGNNSKKGQAHQNTTAWKANKNSKKTRQIAALPVYGLCQRCTDVILWRKKYKKYKPLTTPKRCTGCQEKAIKEAYHVLCDNCARNRGVCAKCLESKEIITTKEEALLGPKSEDEEGEESDDDEEEEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD96</accession>
    <name>A0A367JD96_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001607">
        <property type="protein sequence ID" value="RCH87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD96"/>
    <dbReference type="STRING" id="86630.A0A367JD96"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="672" mass="78744" checksum="4CDCDB674F1B6AD6" modified="2018-11-07" version="1">MKHQQQPHQQFMWLPRLLAKNMYSISIICSALFILLFIWHLPQQQVEQTIKHDKPINRDYYYSNLEQSSLLVTIQNRHQFISFHPLLCRFQHYPVHLVLLPNGDLSQQKAQDVLSATNCQHVDNIVIHDLTTKTEEALFELIKTERTKVVIRSSASRDHLLEAFVDKHEITMITLPEQDINHALWIPDLSIDSLQNWNKVDIKLVIITDRRPHSLSRLLQSALRSVYFGDRVDLNVHMEQSADRVTRMLVNSFMWKQGAKQIRHRIKKGGLMPAIVESWYPSHDDEYAVLLEDDIEVSPYFYAWSKYAILKYRYGRNREAYRLMYGVSLYAPRNLELLPAGRVTFDPNSVLLPRYPPQMPYLSQVPCSWGAVYFPEHWREFHGYLVRRLEDLNLPKNSTARVISVPGSRSDKWKKSWKKYFIELVYLRAYVMLYPNFHQFEAFSTNHVEVGTHFKSDGKRQSVIGTFMVPLMQRDTILSQLPDHRLPFFEELPVLDLWGRLQTHESLDRVAAEYHEHVSTCARTVGSFDPKDIFCRVDGPPDPPQVFPGAAKKPKLPVLVKEAVQPIEYNYKPTYTKEEAERGRTLLFELGPKPIDVAQLTPAEDKSVGRDDEMIDLENDLDTLNRIYYKMNPQNLDFLNDEQEQMEEEEEEEEESFDDQDEVEDDLQIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEG4</accession>
    <name>A0A367JEG4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_003707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001500">
        <property type="protein sequence ID" value="RCH88259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEG4"/>
    <dbReference type="STRING" id="86630.A0A367JEG4"/>
    <dbReference type="OrthoDB" id="2254916at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="527" mass="58478" checksum="1379398874ADFAE4" modified="2018-11-07" version="1">MTDNDEQLQTNTYIWSQSRDQVTITFLVPDSSKAKDLEIKIERQYVKAGLRGQEPVFQAKLYQPINHFESLWQLEKNSMSPFSSLTASPSLSIASSYAFMSSPNHSPNSSMMLPEAVDTGLSEMSDLIAQTGALGSSPPMSETEASQPASPVLLHTPPSVSTPPHLQKTKYRVLTIHLEKEDDTIEWVVPVSGPHHESNALDITSSYLLAQWFEVRMGDLVKALSYYLSAAERGHTASMLKVAGLYEINKETTVAKTVPEKDSKKAFEWYKKAADCVEKELGTNISNGPDPFACYVVGTTYGSGLPEADIEKDYQSALYYYNRCMTITAPRIDVDFSVLDQDHIPRSKLRNHAPHTRDEKYFCSSAFQTGLIYLYGSHPEGQSIHSTTFVDPNPDMAIRYWKEAALLGHAQACYNIGILYANGMGVERDVWTAGKWFGRAIKLDTTNTLVVPEGVKIIDWDATKEEKEEKDTVDASEKKKKKRAKRAKRSSSSKSNDDVIGAIVALGAIAAVAGVAWFLYTRGKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEU7</accession>
    <name>A0A367JEU7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001462">
        <property type="protein sequence ID" value="RCH88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEU7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="79" mass="8620" checksum="15324C264407AB4A" modified="2018-11-07" version="1" fragment="single">PSVLPFKVKVTELGEPSKEERPIKRCKQLGSLVISPILMTQKVLNFSKLQTPKVVLSSSLPQVYDQSFPSASASHSPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF53</accession>
    <name>A0A367JF53_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001455">
        <property type="protein sequence ID" value="RCH88505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF53"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="105" mass="12028" checksum="F7A4CC3EF24770CB" modified="2018-11-07" version="1" fragment="single">MEPVRREHHCRPFDSPTYVPQHRSSISENQSDGYSAPSTPPPYPSYFHNKSQETHKLSIGSEMPLESNRVQSYFDPSDTKTGNVYSRVQDKRSTMVPKLNQKSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFB7</accession>
    <name>A0A367JFB7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001436">
        <property type="protein sequence ID" value="RCH88610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFB7"/>
    <dbReference type="OrthoDB" id="2234849at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="689" mass="79086" checksum="DA0DFA99613C060F" modified="2018-11-07" version="1">MQGKSKPRGNAEAKRKSKKQNTKSDVNGSEIKEQEEVEEQEYNDIFEKEPRVPTKEAEVQEYTEIPENKSQMIIKDVHDEDLLMEPYGVEISDMNVPSEQTELIQPVELAPKQAIPYKALPEELDTISSITLGNTRYDAVIRKSFSQEPFHDDQEQYKNGKGFYRNDEILGELQKQSMIASKAEYVQYIEDIFNANHHDDQSFLNLINTSVDIWMKEWDKKRCRTDRNLQWNNIYGRIHYRNPLPVINEISLINVDDPNALGWRLAHAFTECYDLQEYICLAAQVIEALYEKSINQMYLSEIVESTISYIIESSAYMDAVETFITCIHYLLVKMRDENVDNVDRLVNSDARDIATTLKSLLKLPISSASTGVSISMYQSGLDSFNQLMSNILEVTSHNDISYEPIKSIWSNIKINKVTTGSFYEQVKDMTKHLFAIYEKTQDNGAYVWDPREATSKIISLLEPFQGSFAPLQVALIKQLCSKVFINMERKYPTLQANYYSLLMKQFPALCERHGSLLIEHMEVFGVGSYHFTFNDVEIDLSNAIPKRAWSNIISTVDDSASGLYKKDITTYGFTNASLTCKVPHFEYKKVEGIPPWEDSGEAAIDIKNISFQVKIQTISEEYFGFSTQVLGCRCNIGHMDIHIKKSQYPEFVNALALRSIKTNAKARLEQELSDVAQTFFKKVFSVKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFS6</accession>
    <name>A0A367JFS6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001403">
        <property type="protein sequence ID" value="RCH88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFS6"/>
    <dbReference type="STRING" id="86630.A0A367JFS6"/>
    <dbReference type="OrthoDB" id="9986409at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="39342" checksum="DFC148163334E841" modified="2018-11-07" version="1" fragment="single">GDMGFGRFLIRGSRFINGQYTPFAYPWRLAQPIEIGQYIAWSAYLVHQIGQLLILAKVQLFKKEKLIRWSDDYQWWNWQMVYLNTFMLVFKLIHGHIFYDGLAATIPEGIAQGSVVAILVIAVVIAIPRRGIMLGLGKHSAPDVVHFVKKYHGYLMSFGTVLNFHYHPVEGTMGHLFGFVYQCLLIWQSTNFLHKSHRNASWILLLETWVFIHGTLTAIIQPGIGWQIFSYGFAIMFLLNQVYQTQICQSKMIMIVAHTVFAFSMYLGFKNDKAYYRATFIPVTEYTCVYLVLGVGNLAVYTIQRTNSFSLKLLVTLSASALVSIVITIGLAYVLAGNLVVYNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGI9</accession>
    <name>A0A367JGI9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001356">
        <property type="protein sequence ID" value="RCH89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGI9"/>
    <dbReference type="STRING" id="86630.A0A367JGI9"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="367" mass="42766" checksum="3579120BEA904DA3" modified="2018-11-07" version="1">MSLLSIQQLQFNGENKISYTEPEMYALSNMLNRDHHVTATTNNNNYYHQHQHHHHHRLPSVTAMKRPPFMNHYNRLAYVDALVDANAMAIESIWNMKLTANNINVVPLRTFIQEVLKRSRTTYSTLQTALFYLFRIRPSVVSHLSRMHHRQPYWEDAYVSCGRRMFLASLVVASKFVQDKTYRNSAWAKIAGLPVSEINAAERIFLNMIDYRLYISQPTFEQWYQLLHIHIEAKTQNQPTHLHDLNLNFNPPDLIHSPTSPSTPPSFSPNTPTGWTLLLSPNTFLPPKDTSKQRYRKEEDHCYYPHPIRPQPLPLLSMSLPSSIHSSPMQTPSPVRTSQKRKYTDDEDHFSIGYHVSHVRQSSKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHJ6</accession>
    <name>A0A367JHJ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001289">
        <property type="protein sequence ID" value="RCH89432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHJ6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="65" mass="7427" checksum="22EBB0D8904988FD" modified="2018-11-07" version="1">MVKKKKEYISEVEATPCRSCKHSTPYAIKPLAIISMQSPKAWHNLIREVSTPTKLLALRDLFEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHX7</accession>
    <name>A0A367JHX7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001273">
        <property type="protein sequence ID" value="RCH89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHX7"/>
    <dbReference type="STRING" id="86630.A0A367JHX7"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047315">
        <property type="term" value="F:kynurenine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000071">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000166">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="429" mass="48121" checksum="24B856A60AF26DF8" modified="2018-11-07" version="1">MDYSKHISKASQARNPSAIRALMPYLNCKDMISLGAGQPNPATFPFASLTLTLKTGEKIEVDDQLFDRSLSYDLTSGQPLLNQWLTELQRIEHNPPVEFDVSIGSGSQDLLTKALEMMINPGDSVLVEEPTYTGALSFLETMPCDLAPVATDEFGIIPESLDHLLAHWPESNPSGKKNQPRPHVLYTIPSGGNPTGVSATLERKQAVYKICSKYDVIILEDDAYYYLQFDEKRTPSYLSMDVDGRVLRCDSMSKILSSGLRIGWVTGPQPLIERINMHTMVTNLQPSGVSQVVAYQLLAKWGHKGFFDHVKGVANFYREKRDEFLECLNKHMKGRAEWNVPNAGMFFWLRLLGGITDSYDLVMTKAIKENVLAIPGLAFMPRGNKNEYIRVSFSNVSKQQMDEALRRLARVIDREAELHGLRTNNSSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI65</accession>
    <name>A0A367JI65_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001265">
        <property type="protein sequence ID" value="RCH89575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI65"/>
    <dbReference type="STRING" id="86630.A0A367JI65"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="558" mass="63068" checksum="68FCBAD643C5B490" modified="2018-11-07" version="1">MHLGLLSQEKISFDPIKPLILRGPPSENASSVFTGTVVLTLSKATKITGMTVTFKSVATTYWPEGIGNRGTRLTHEKILSEESVQILEARKNEFIKLPAGTHRFPFAFIVPNSIVETIEDVYGRVRHTVDAKVALYASGLQQILNSWHVSKPVLVLRAYMSDSLLTNNSLQDLSRTYEKNLPAADIQLVVERAAFSSGDLFFLRLILEPHRKKVRLEHMELSVTENRRYNVAEARANRTDTEVFTLLFLKSVKLVEGGEDVTDGEGDLRSVFTKNGNAVELTNTIAYRITFATPTCMRNIHHTTYYKDILFRHHLNITMTISFVDNDTNFSRPMLSANSSTSSFGEETSGSTIQQSSAIPNTNHISMDHSIEQQAAQVANTLVTPPPAAFSPNTHPREPILTNTTVIHHMNNINTNPSQQSMWLSKLRKPTNQKENGTQVIRKRETIRLETPITVFDCRLKEDYGRLPSYSELNVTSDLSHGDDKNKMLQEIMEQDLMLQCKPDSDEQIPSSEPQPQLCPCYFKFRRQMEMASQFQLFSTHNKLEKIPSIPPPDYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJD0</accession>
    <name>A0A367JJD0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001184">
        <property type="protein sequence ID" value="RCH90052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJD0"/>
    <dbReference type="STRING" id="86630.A0A367JJD0"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703130" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="14514" checksum="08ED24B8E3468EBE" modified="2018-11-07" version="1">MSIKYILFFITFAFTYFVSAAPIAKKDAEAGSLVTRGGSYSGDGTFYTPGLGSCGWTNSETDYIAALNHVQMGNGANSNKNPNCGKSITVKGPSGSVKVKIVDTCPGCSSGDVDLSPAAFQKIAKLSQGRVPITWSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJM1</accession>
    <name>A0A367JJM1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001170">
        <property type="protein sequence ID" value="RCH90140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JJM1"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="4">
        <location>
            <begin position="698"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH90140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1708" mass="196778" checksum="9306670093740E3C" modified="2018-11-07" version="1" fragment="single">ELVSGRYRFFNNVEGGNTIIRDTICQVLSTDWALRPDLARLSTRYRRARMPEEEDDSFEFGDEDGGMDSDGDEIMFDADNVIEEDVGEEFEEGDEGEEHEEGDDESSSNSETHRHLEFIMGHHLEWHRNASERLAEEARLHVDADRLHEERDQEILKRRRSSSSSQPKSHKTHKPRDILDMEWNLDAWLDYTDKLELAERQIAKDMGVPLNHGATKSSAEINSNLKKEFRRKLRLDYILQFDLRLWKTARMDIKDLLIGTFISNYEYRPILGVRFARNYPELIDAFFFKDREPENSVSTLSVQLLTVPTVASILVKDYKFFGMVCSILSNFFLTDRIHMILPEDYSQAQVDPSFRAIARHRYAYTIYDLRYVMNAEQVKLEISKSPLYLRHFIDMLYQFQAMDPLKRQSDAHVEYESNTWMNAFNVTLQIVKLCRLYAACFDALQSEIPIVHASYNLCRTVYRVLKAIRDWNPRLSPVSLPFPNIAQNRIIIKGISEQKYHQVSTPHIGPFDIIDYDVTVQPVSFHHPFHWLLSELFENVSLLYDEVLAENGWIGGFKQMVNNALQDDRRATFLDILEYPIRTLTILSQINCGVWVRNGYGIRNQFHTYRDINVRENTLDRDIFLLQVGFVVCNSDQLLLTLIDRFQLQDWFKGKWGKTHPVYDSPQKTFMVEELLNLLIISATEHGYASGTSTEQRIRRAIIQYLGLSSLSYSELLKLIPDTLTEHESFEAELNKVANFRAPDGVNDKGMYEIKPECLDEIDPYFWHYTRNKREEAHVVLRKRWNQLHPESALNDKEEFLVQPKIHRIEKGPFRHLNNFLHSKVFCQILIYALWNSKIAKQAKSETILDEALYLGILAVTDVNNEQSDIDPFMDTSGGFVENATENEYAIQVNEIERVHSTLLSVLIHCVDDKELSHTHKRLCFIIDKIEQLGNQKAKDMIGEWKERRSKHISFDNQGNSSGDGMSEYERKKAAAKARQAAIMSQFAQAQSKFMEQHADLYKDEEDFKDAMDEIPANDDLMSSANEFEIVRKCHFPTDNCIVCQEELDGSQLYGMLGLVQRSNVQRLSPVTKDVWSDILDTGLHLHNPWGPREEASNDKGTHFTAFPTGSHVPGVDISSCGHLMHAECFETYQQSVDNQDFMSRLSLTRSPKGRFLCPLCKALGNVLVPIVWKGKKETYPGVMAPSTSFDDMVKSLLEVAVDAGEKVAFKRRTGLPQDSNLVIADEERLKYLYNKLIRAIYKATGDESGEFVTDLKDSLYYLYDMYAYTISNFEVAQRGAENTRARDLMVEHTGTFIDDISRTSQTLLKILSMTNGLVPKLMESPWQTDDHQVAESVLLEQLHQLISSPDKPSTVPVLSDDPFKVLVRLGFLVADYPEVQAHHLMRALYLADLTKTVIGIAQVMCDNERLFKDTRLNELLTALCDDQQQQVKGVDGAKRFIEHVLSSIGFPHTKTVFDRLNPKGFTALLRLFTLPYLRKSLLLMTVHHGFIPQSPSPTDAMEEGSQSEYDRLLDTLNLPSFETIFNFTNTDHELLNYWCQDFLDRNGTHISLNLPIKYRLTTLPYRLDVLLDESSKRICRKCNSVPEHSAICLICGTFVCARRFCCTEGTKGECNVHMKSCGGEIGIYMMIKDCFLLLLHDNGGSIMNAPYLDSHGEADIFFKRGAPQYLNMKRYEQIRQMWLTHSIPSFIRRRMEASQTTTAWEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJU8</accession>
    <name>A0A367JJU8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001156">
        <property type="protein sequence ID" value="RCH90222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJU8"/>
    <dbReference type="STRING" id="86630.A0A367JJU8"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25158" checksum="5D39176081AE162E" modified="2018-11-07" version="1">MSDFGDFNTPSEDPTADFLARERAALGEDADLFNTEPIQSPAVTNLMTPSTLPMSPSVFTEPTPTMSAPPVDNTYSSFEAEFPKAEELETSQAFYKALLPEEEPETVRHWREKQAEVIAERDAVSSKKKEDLVKQAREEIDKFYEDYNDKKQRAIEENRAREESTEKNRENISSSSNVWERVVSEVDIKSAKTGYHTRDVSRMKELLLDLRKDTSAPGNVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJY8</accession>
    <name>A0A367JJY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_009093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001152">
        <property type="protein sequence ID" value="RCH90248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJY8"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016702499" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="163" mass="17597" checksum="3C58D166A8E10C83" modified="2018-11-07" version="1">MKLTLLLASLGLPLTVMSLDAQKPFMAPDDHGAIWSLCGDPSSHLLVGYRNGVHISPETPRTGSDISVQVQGNLIKDVTGGKVDIDLNIMSMIKIKKQLDLCTVLASDIMGHKSCPLSAGDLDLDATAWIPKELPKLPLDGNIRISDQDNNTVTCIHLSFKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK03</accession>
    <name>A0A367JK03_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001154">
        <property type="protein sequence ID" value="RCH90236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK03"/>
    <dbReference type="STRING" id="86630.A0A367JK03"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="89"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="314"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="54039" checksum="71B247EFEA1308AC" modified="2018-11-07" version="1">MYGTNYSRQYETEHNVIDKSTARKSDPSIISAVSSNLSSLRLSEMSSSGASATPDWMTSNHHVEFDIIDSLDYDDVDDGLIDQEMMHQKRESIIKELHNSEKMYIKNVLEVLRDSYILPLRKSAKQPSYGFLGMKKPPCTERETNWLFCNFEDIIRIHQEILTSLEERLAIWGPTQIMSDVVLTWFPKIQEAYHVYFDNYSIMVTTVERLNRYPPFKKFSESVEKGLTKEKTLLHLLTTPVSCIPRYGKLLSALADSTYSLHPDYAGLMQCKQRVEQLFEEFKMRIAEAKNIDQVYEIHTTMTDQPFGIRAERRLYLQGDFIQITKSNTQEERTYFLFSDMLVYVRRKQNSLQYKGHIQLERAKIRLLPKDEVNEEGYCIEIISSFQGVDSLNTTFMASPTVHIMKLPSKAEQMKWKACLENSVSHIEQLTMQSRLQTSNSSKLTPPGSIRKQGTTISNESSKSVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL37</accession>
    <name>A0A367JL37_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001089">
        <property type="protein sequence ID" value="RCH90648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL37"/>
    <dbReference type="STRING" id="86630.A0A367JL37"/>
    <dbReference type="OrthoDB" id="10469475at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="261" mass="29458" checksum="96E4145EBC681A6B" modified="2018-11-07" version="1">MSQEGHESTKNKEQQLTDKQQREKKTKNFSAWDKIRENITEFGNDAFHHASILTSDSPSPSRANIPKSNIPPVHKKQTYNPFLRNQNGFDYNKMSLANTTLVAAQAAGMSNFVRGFKPKMGAGRHNGAIYATSTAVQQDIYRLERDLEKLLSHINTRSQDASFIDNNAAVKKELNNFSVKASKKTKFLRYSTTLSDELLEQSEQASNVTRISANMTSIMDIMKKHKSATRLPFSSDILAVLFVPFDRKPQKSKHDNVNFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLE5</accession>
    <name>A0A367JLE5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trafficking protein particle complex subunit 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TRS33_2</name>
        <name evidence="2" type="synonym">TRS33_1</name>
        <name evidence="2" type="ORF">CU097_007245</name>
        <name evidence="3" type="ORF">CU097_010067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001648">
        <property type="protein sequence ID" value="RCH87479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01001110">
        <property type="protein sequence ID" value="RCH90511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLE5"/>
    <dbReference type="STRING" id="86630.A0A367JLE5"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000008">
        <property type="entry name" value="trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="19895" checksum="97D7C8C914F98912" modified="2018-11-07" version="1">MNYNEDNSSSIPPRLVSETCMDLFLIEMVDTVCRTTTSEPDGDNDAIFYKLETLGYVVGQRLIERFTKDRLRFVDTLDVVKFICKDLWTIMFKKQIDNLKTNHRGVYVLQDNGFRWFMRMSTDVGGADSAKKAMPYVWFPCGIIRGALASLGVPSVVVAETSNLPQCTFQIKIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLT4</accession>
    <name>A0A367JLT4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DAL2_3</name>
        <name evidence="4" type="ORF">CU097_010783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001050">
        <property type="protein sequence ID" value="RCH90904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLT4"/>
    <dbReference type="STRING" id="86630.A0A367JLT4"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="438" mass="49462" checksum="60F98DB5AEA85351" modified="2018-11-07" version="1">MGNALSKTQFIKLDANDVNETVLEEYAELSSLLRNSSIEFVSDEYYGKAENLLKQESVDVNHCLYQEGTKDGWQVQRHLNTAHVIIKLGCTGTISGFDIDTTGFMDAAPTNVLVEGYVENKNHGEKWITLLPNVPIDMNAHNFFKIQHDQHIYSRIKLTTAPGGGIARFRCYGHVVPIWTNLKKEYNLASANLGAQIVRWTDVDHANKPNILLDNGLSPLDGWLTPRSRYEPRNDFVVIQLATLGVIKDIIIDTTSFIGNIPKYISIEGCNSNEIDPYRDPNTEWFKLVDKEPCAPNSSVAYVVDYGLPVSHIKLTLHPDGGIQQIQVLGVPYTGEQQEDILTVDQNEAMIENEEITEKEERQLDNQITKELGNLLFPTPPLEQTVITTTTKITQKRRKSIELVQEEPPAKSIKPHQEPESEKTSRNGTRRNRSSRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMA1</accession>
    <name>A0A367JMA1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHS3_6</name>
        <name evidence="13" type="ORF">CU097_011119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001037">
        <property type="protein sequence ID" value="RCH90989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMA1"/>
    <dbReference type="STRING" id="86630.A0A367JMA1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="302"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH90989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1112" mass="126489" checksum="FA46F846D9A3719D" modified="2018-11-07" version="1">MSQDNPKTTASSTDDAPKALEDQLTQTYESFNDFNEATNLGSTPPQSSNDNERQENPTTARSEKFSESVDIKTTGIQRLEDLQRARYLNKKDTDLEKNKQQEESKATIKKKRPSCWVTTTWVLTCWTPPVLLKACGIKDKGMQQIWREKVSLVMIIVFLCAFVGFLTFGFNATVCGITPNRIRPTGVEESHIVISGRAFDLKTFRHPSPVPGMPQSGDLQELGIGGRDLSFLFQTVNYNCKNILKPIIPDDPEGNVANYFPCVSLDRYNPKINSTDNPHRIGCHATPRARVSLKRLNVIGDVYYNWTDIHEPGTSLMVFNGNVLDLSRLRYLTPNIPLPIQIAQIVGPGSAFIGRDATYWLSTTADRLKLGKCLTDILKVGVVDTRSTGCLLSDIVLYISLAVILGVVFIRFFLALFFGWFISWNLGSIREETDEDRKKRQNQVLEWEMNNVEEMHYRRTNSIVFPRDEPGIDPSNNELRNIPEEIAMTPSLALPKNTKHRFFPSKSRFTQPQSPRSMYSPNHSRAFGSMLFADDHTVEIASPHIPYTLSTRFYKNFEPSLPTAESAANIQAKKEYNFNFDLIHTLMVVTCYSEGEEGLRTTLDSLANTDYPSSHKMLLVICDGIITGSGNSKSTPDIVLTMMKDDLVPKDRVKPYSYVAISDGVKRHNKAKVYAGYYKYNTDEDGRFPVIPEDKQQRVPMVVVVKCGTEMEAKEKKPGNRGKRDSQVILMNTMQKIFYGERMCELEYQLCKAIIKLTGLHPGRFETCLMVDADTKVYPDSLARMIACMSRDPYIMGLCGETKIANKSDSWVTAIQVFEYYISHHMSKAFESVFGGVTCLPGCFCMYRIVARKGDRIVPIFCSSDIVEMYCENVVDTLHKKNLLLLGEDRFLTTLMLRTFPKRKMMFVPQAICKTVVPDTFRVLLSQRRRWINSTVHNLLELLLIRDLCGTFCFSMQFVVFMELVGTVVLPAAILFTIYLVVISFFVRPVPIIPLMLLAAVLGLPAILISLTTRKMIYIGWMCVYLLSLPLWNFVLPAYAYWHFDDFSWGQTRLVEGGEKKEDHGKREGEFDSSGIVMKRFDEWHRYEMNIVKEKHTSSATRNYSSVYYGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMP3</accession>
    <name>A0A367JMP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001004">
        <property type="protein sequence ID" value="RCH91214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMP3"/>
    <dbReference type="STRING" id="86630.A0A367JMP3"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="205" mass="21948" checksum="B8970A1BED975681" modified="2018-11-07" version="1">MAPKVYIIIYSLYHHIYTLAQEVQKGLESTGVEAKIFQVPETLTEEILTKMHAPPKPDVPVITVNDLKDADGFLFGIPTRFGTMPAQLKAFFDATGGLWASGALAGKFAGTFFSTASQHGGQETTAFTTVTYFAHHGIIYVPLGFANPHLFDNSEVVGGSAYGAGTIANGDGSRQVTQKEKEIAQTQGENFGKILSAYVKGKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN02</accession>
    <name>A0A367JN02_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000998">
        <property type="protein sequence ID" value="RCH91249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN02"/>
    <dbReference type="STRING" id="86630.A0A367JN02"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65598" checksum="BA6F3C79EE5FE65E" modified="2018-11-07" version="1">MATNVDTALNVSNKSKCISCKIASIPCNGTSRPCVNCISLGKPDTCVDSYLANTIQTTKNTKAKTQKKGHRPHVPSACINCKIAHLACDVSRPCKRCVTLKKEDTCQDIIHKKRGRPKRREQKPYANSEYTYEIIYGTIETPAIVSHNRKDDSSTTITEKLEIKAANRTKPIAFVHESFQTSSQSDNHNLTVHKPNVDQQALSILQPIQTSALTLPQEDQQPFLIDQFNIFNTTTINDETNNDIQSPLQNKEGKEITLILSMEVCCAKVPNGIYNAWGYYPQELAHRSLYDFISPKDNDRLSQLHRLLLDHIAKTANQGNVVPSTERSTSLLFESVDEAKLKEIASGSKLYSDTIHVRMRSGEYKLHEVVLYIGGGLGADLYNQATLSKQYIVAIFREHQYEVSTINQKNPCIESFENTFQAMSNYIEPIAVFSPMSSPITPPTPAVDHLLSSLSASVIDDKSADYWITDNNHNTGDNILTYASLNRKISTPHKPSLKPPKFNIAPITTAPTSSISKSSISLNPLLNRFASSPAVTHPTHQYFLQTSSSTLNAAASAVKSSRSVYSISGSSNRDNNTISSGRAIEMSIRSLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNJ3</accession>
    <name>A0A367JNJ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E2 ubiquitin-conjugating protein mms2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MMS2</name>
        <name evidence="3" type="ORF">CU097_012872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000959">
        <property type="protein sequence ID" value="RCH91514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNJ3"/>
    <dbReference type="STRING" id="86630.A0A367JNJ3"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="16005" checksum="2BB84EE5AC28C18F" modified="2018-11-07" version="1">MAQGKDDNLNIPRNFRLLEELEKGEKGIGDGACSYGLADDDILMHNWHATILGAPHSVHENRIYSLKVYCGDNYPSEPPSVQFVSRINLPSVNPQTGKVEPNRLPCLANWRPNYTLETVLTELRREMATVGKKLSQPPEGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNX3</accession>
    <name>A0A367JNX3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000943">
        <property type="protein sequence ID" value="RCH91626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNX3"/>
    <dbReference type="STRING" id="86630.A0A367JNX3"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27732" checksum="2ED9EBBE06BF71DD" modified="2018-11-07" version="1">MTIKIQVFTDFDGTLSIDDTGILLIDDHRSLGTERRKVLDHAILNGSITYRDALQEMWDNVHISWEEAWRDHLDHCQIDPGFPSFNEFCRENNIPVTVLSSGLYPVLERIMFNFLGEKSKDIKIVCNNAEIKDRTWKIIWRDDSEYGNDKSKTLIEARQNAPKDTIFIFCGDGVSDISAARHADVLFARRGRDLEIYCQRENIPFIAFDTFAEIEQVVRDLAEGKSKLEKSDTGFCKIIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPL9</accession>
    <name>A0A367JPL9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000906">
        <property type="protein sequence ID" value="RCH91894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPL9"/>
    <dbReference type="STRING" id="86630.A0A367JPL9"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="62" mass="7132" checksum="81C5449225FC2875" modified="2018-11-07" version="1" fragment="single">MSANLNFGPEWMRGGFSKNANNNGVLTDLPFEENNINAFKYSKEYMLSLYKPSQLPSDFQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ78</accession>
    <name>A0A367JQ78_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GPI3_2</name>
        <name evidence="11" type="ORF">CU097_010579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000876">
        <property type="protein sequence ID" value="RCH92104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ78"/>
    <dbReference type="STRING" id="86630.A0A367JQ78"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="10">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="196"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH92104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="456" mass="51751" checksum="2513C247E8E3602B" modified="2018-11-07" version="1">MFNVCMVSDFFYPNMGGVESHLYELSQRLIQRGHKVIIVTHAYGHRTGVRYLTNGLKVYHVPAKVIYAEATLPTIYGFFPLFRHILIRESIEIIHGHGAFSALCHEAILHGKTMGLKAVFTDHSLFGFADASSILTNKLLKFTMSDVDHVVCVSHTSKENTVLRAALSPKHVSVIPNAIVASRFLPDPTAPDPNWITIVVISRMVYRKGIDLLVAIIPRICEMYKNVRFIIGGDGPKRIDLEQMREKHGLHDRVELLGPIKHHEVRNVLIQGNIFLNTSLTEAFCIAIVEAACAGLFVVSTKVGGVPEVLPSHMINYAIPEEDDLVIAISKAIHMFKFGKVDPSKFNNEIKDMYNWSNVAERTEKVYLTISQTKSSPLIERLRRYYGCGLYAGKIFCMVMALDYLIWMFLEWLFPSDTIEKAKPFPYQKYRQFIYDTSNRSNSTLNELSSVEEDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS58</accession>
    <name>A0A367JS58_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ketol-acid reductoisomerase (NADP(+))</fullName>
            <ecNumber evidence="6">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ILV5_2</name>
        <name evidence="20" type="ORF">CU097_012379</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000780">
        <property type="protein sequence ID" value="RCH92783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS58"/>
    <dbReference type="STRING" id="86630.A0A367JS58"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="18">
        <location>
            <begin position="53"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="19">
        <location>
            <begin position="243"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH92783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="394" mass="44264" checksum="C213101B6F745901" modified="2018-11-07" version="1">MASRAFTTALRSVARASSRSFVRPMTMMTARLAVKPIMTTQVRGMKTLDFGGTKETVYERADVPKEKLLETFKNDTIAVLGYGPQGRGQALNLRDNGVNVIIGQREGKTYQQAIDEGWVPGKNLFPVLDAVEKGTVVMNLLSDAYQTEIWPQMKPLLTPGKTLYFSHGFSIVYKDQTKIVPPKDIDVILVAPKGSGFTVRRLFQEGRGINSSFAVYQDASGKAKERTIALGIGIGSGYMYETTFEKEVYSDLFGERGVLMGAIQGLFQAQYEVLRANGHSPSEAFNETVEEATQSLYPLIGERGMDWMYSNCSTTAMRGALDWWRPFHDASKPVFERLYESVRNGSETARSLEKNSQPDYREKLEEELREIRESEIWRTGKTVRQLRPENVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSU9</accession>
    <name>A0A367JSU9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000751">
        <property type="protein sequence ID" value="RCH93020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSU9"/>
    <dbReference type="STRING" id="86630.A0A367JSU9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017016706" description="Cytochrome P450-dit2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58151" checksum="7291A2D2763C5DC6" modified="2018-11-07" version="1">MTDTILTRTLGLSAAVLTALAIKYPDRAVFDEHREGISYKKGWPLLGGLPAILSNAEKLHDFFMNGFTEMDSLTTTTSAFGMPRAIATIDPRNVEHILKNNFENYAKGPNFNASTEDLLGHGIFNANGDQWKYQRKTASHIFNVKNFRDHFTEVFVKELGIMFTGIFDRAAETGEIIDFHDIMFKFTLDSFILLGFDVQLNALSSKDKVPFAASFDECQLNSFQRFVNPFWRLTEPVYTLLHPWQKSIKQHLRTINEFANQVIENRRADMEKGIKTHRDLLSRFMNATNEHGEPLNNKELRDIVLNFVIAGRDTTAQALSWTFYNLLLHPRVEKKLLEEIQLNITDELMDNPVALYDAIKKMNYAHAVFYEVLRLHPSVPNNQKYALNDDIWPDGTEIKKGDYVIWCPWAQGRSEKVWGADAKAFKPERWITQTGELRRESQGQWPAFHAGPRVCLGQNLATLEALVALVFIVKRYKLTLTPGQNITYQVSLTLPMKDGMKVQIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT01</accession>
    <name>A0A367JT01_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_012286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000744">
        <property type="protein sequence ID" value="RCH93084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT01"/>
    <dbReference type="STRING" id="86630.A0A367JT01"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="281"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH93084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="439" mass="48853" checksum="4C9F093E12826AC8" modified="2018-11-07" version="1">MTDYEYLSGFGNHFSSEALPDALPKGQNTPQKCPYNLYAEQLSGTAFTVPRTHNQRSWLYRIRPSVVHQPFKPHEEPTLLVSKYGGDDVLITPTQIRWSPFDLPADNEKINFVQGLKSLAGAGDPACRSGLAVHVYTANTDMGKSAFYNADGDFLIVPQQGTLDIYTEFGKIKAEPNEIVVIQRGIRFSVSLPDGKSRGYVLEVYGTHFELPDLGPIGANGLANPRDFLTPVASFEEEDNVEWQIITKFNGRLFSAKQSHTPFDVVAWHGNYAPYKYNLANFCTINTVSFDHIDPSIFTVLTAKSDTPGVAVADFVIFPPRWAVAENTFRPPYFHRNCMSEFMGLITGDYDGKADGFLPGGGSLHSIMTPHGPDAAVFEAASTAELKPVYVGKGNQAFMFETSFMLSLTHWGLETCGKVQEDYWKAWANLENKFNRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTU3</accession>
    <name>A0A367JTU3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">JMJD7_2</name>
        <name evidence="2" type="ORF">CU097_003357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000718">
        <property type="protein sequence ID" value="RCH93269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTU3"/>
    <dbReference type="STRING" id="86630.A0A367JTU3"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="129"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="338" mass="38837" checksum="C74C8DA8EBBF7885" modified="2018-11-07" version="1">MSVLKDIETVLIDYVKEYQDINGTFIHIYDNPPTPLEFLRTSVHPNRPAIIKGAFDHWPARHGWTNEYLRSKIGKSVVTVAVTPNGYADAVTYDPLTKKEYFVMPYEQKMTFNSFLDIIEGRTPSDNANYISLQNGSLSLEYSALEEDVDPGIAWCSEALGKQPDAVNFWFGDDKSITSLHKDPYENCYAVVRGQKTFILFPPAEHYCMHESVYQNAVYEPNENTGKLEIKPLESTTPWIPVNPLCPDFNRFPRFRNAQPIKITVNEGELLYLPALWFHQVMQSGEQGVIAINYWYDMDYSNILFPTTNLFRKLLTGVIEGHRDLLNQDEKNNGELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU96</accession>
    <name>A0A367JU96_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AMD1_1</name>
        <name evidence="3" type="ORF">CU097_000220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000691">
        <property type="protein sequence ID" value="RCH93488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU96"/>
    <dbReference type="STRING" id="86630.A0A367JU96"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="225" mass="25872" checksum="9D2DFC649A2CEB31" modified="2018-11-07" version="1" fragment="single">MVHSSDLDSPTEINDFDHTPYFDYHHLKAIESHDSKYLCQNLSVSPVQRHLSELNLENDDPSALKASDATQNLQAKIEKDDNVITAELRELYGALQKCLELRERYIAESRQRLFDDPRNQDDWEIYPPPPPPSWPLPSPEELERRKAKEKAREADPVAAVGSDFHFDHCKIPGEHEYDYRMGPDGFFVVYNGQQPIHSVTSPKQFYEDLEYVLNVISDGPAKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWW0</accession>
    <name>A0A367JWW0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MLH1_1</name>
        <name evidence="3" type="ORF">CU097_013668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000574">
        <property type="protein sequence ID" value="RCH94482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWW0"/>
    <dbReference type="STRING" id="86630.A0A367JWW0"/>
    <dbReference type="OrthoDB" id="2289912at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein Mlh1 C-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="36456" checksum="3B57ADF5783A4EA5" modified="2018-11-07" version="1" fragment="single">QLDTSTISRIAAGEITQHPVNVVKEIMENSLDAGSNHIHITIVADSLELIKTKYDGHGIHVQNLFANIAQRRKSFKSSLEEYKRIQRCIESYAVYHYQHGFTLKQDAITDLLRASTPDQIARVQKVYGKSISAHIEILEHASENFSLKRQFGNGNFKRPLLSHESFSHQSTWSTWKNSLSLPLPIRDMLELVSQDEDEIRDMVKTILLHREILDAYFKFSVTKNGQIASLPMVIKGYVPSLDKLPIFLHNVAIQVDWDDELNCLYALAREFELFYCSCSKDQCGLVLKAIRQSKFCVPRYIGPSCYFIELDFPNLDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXG5</accession>
    <name>A0A367JXG5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000559">
        <property type="protein sequence ID" value="RCH94608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXG5"/>
    <dbReference type="STRING" id="86630.A0A367JXG5"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="30301" checksum="38227CD91F7D9129" modified="2018-11-07" version="1">MEAVADFPEGFFFIRCKAKSFALDVANGSMTNDTPIIIWPQKMVDSINQLWMHEDGFLINKKSGLVLDIRGGIERDKLIIQYARKPGLAHNQRWKYQDGYIFPSAAPHLVIDIKGGEYKNGNNIFLNTKNPHSPTQQFIIQPFENEKSRQELALLRPSPLQRNSLFPRQEELYDCYRVVYLENKQVTPEQLAGAVTFKAMKDYITSIKNKGEPIVANDDTRRTLCEIVKQEVHRTLTQAQIHNQELVSSASMVAESYFSREYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXQ0</accession>
    <name>A0A367JXQ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Grainyhead-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GRHL1_2</name>
        <name evidence="2" type="ORF">CU097_009558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000552">
        <property type="protein sequence ID" value="RCH94665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXQ0"/>
    <dbReference type="STRING" id="86630.A0A367JXQ0"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="1">
        <location>
            <begin position="56"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="363" mass="41826" checksum="097D62C2CA995104" modified="2018-11-07" version="1">MNPIENLCFSNPIEPKYFNLQTQDGSRPHYRHFSANDMMVKPPMYIQQESLDEKQRKLRFHVVLEAATAVTQRAEESSITYLNRGQLYCIQLTDTYNQNETITSSLSIEFHNASHRSIAENYWNYWLAQQKQLESRAIDIDLSQSVGIVNATMPSFDKISFEWNGSIGAKLCVRFKCLSTDFSRIKGVKGIPLRAHMESKTENEQEACYCKIKLFRDKGAERKNKDDAKQISKQLEKVYGSANPQSLSLLYKESSPYTVFSETLQENTRYHTRTMTAPNATALQPMFPMDMSFVPMTTSTPLLYIPPLIEEENESLYTPLQSTPTDAFSIYDVFTPQEIQHDYFSQQLSLVQDTPQTCQYGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY68</accession>
    <name>A0A367JY68_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_010151</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000561">
        <property type="protein sequence ID" value="RCH94591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY68"/>
    <dbReference type="STRING" id="86630.A0A367JY68"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH94591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="459" mass="52095" checksum="11B2C62882DAFDF8" modified="2018-11-07" version="1">MIPFVDYYCSCSTKDNLEGNSDESTESVTGLHLLSKKAKNYLYPLSRLYFCEDCHQIRCPSCVQDEIVSYYCPNCLFEVPTASVKSEKNRCARNCFQCPICQNTLSVVASQEPNQTSTTVTAPAGPYFLACNVCRWTSQEISMTFEKPTSLALQLQKNEEALPDTKEFDQLKEHFEKHLRVNSVPSLPTTFLSFTSSSAFSKYMGTDSSGSGGKIDDINGYEPSVQIPDDDLKLLDSMITLRNIDKVSTLTQRSTQLHDQPHELGKIHPQRIHLAIKRSKRCRTCRHILIKPEQKAQATRFKIKLVAMNYIPNITLIPKKNWPLQVNVPTQILLKFTNPLYEEMHITLATPLLKENANGRVTILCPHFTVGAYNETIEYDDEMYPRRNNNHLSLPLLVTYNYKSDEDRMDVSSGDIDADDIMDDTDDNSSLGKKSNIRLEDDKIKSYSFWCLIGLGSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYK1</accession>
    <name>A0A367JYK1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000510">
        <property type="protein sequence ID" value="RCH95034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYK1"/>
    <dbReference type="STRING" id="86630.A0A367JYK1"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="267" mass="30647" checksum="35C561AE8645F85E" modified="2018-11-07" version="1">MSRAITDIIQQWRTIIKPTKGPRPTVNQLKEIIKTRPNSLEAKIATSPAARIMASPLRQCALQRRIFPSKLLLRFGLGWHPETRRVWAYPTVQGKTHGTGYYVSLQRHLLDALKGGAVYNSVFRGNAMYRADMTDHVRDALCQASLKEFLKIPTSSIHILQPVDESSWVSDKPAPMGYQCIILLQHNHTGFYAHDHSVYIQSEDKTQKDIPCYYIKDLWSDKQISQISQRLNMTPEQQRVSALGVRKSFETVDLAVELWRCREFIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K051</accession>
    <name>A0A367K051_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000482">
        <property type="protein sequence ID" value="RCH95281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K051"/>
    <dbReference type="STRING" id="86630.A0A367K051"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="291"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="574" mass="65790" checksum="1671B834F8B307D4" modified="2018-11-07" version="1">MSEVATPVTADGPIKDAAVKKAQKQRRRNKKKSKKQRLAEEAQRKELEKQHEKDDSLKDVEVEYVVQPIDLSALKKVDGMSRLDENTLQQFSEIFKHFQNGKPEQDEEEFPVYDKSQVQNGDINEADEDEENKESEQTLSKKKLKKIQRLTVAELKQLVKKPEVVEWWDVTASDPKLLIWLKSYRNTVPVPAHWSQKRKYLQGKRGIEKPPWELPDFIKDTGIMEMREAVREKENAAGLRGKMKEKVNPRMGKLDVDYQKLHDAFFRFQTKPKFTIHGELYYEGKEFETKLKEQKPGQLSAELKEALNMPPLAPPPWLINMQRYGPPPSYPNLKIPGLNAPIPEGAQWGYHPGGWGRPPVDEYNRPLYGDVFGVAQPEAAPPEIVEPVDKQLWGELEPEEEYEEEEEEEEEEEEEEQAEKQPEEEAEAEAEATQDLADGLETPSGIASIASGLETPAHIELRKDRKREEDEGPKQLYHVLPEVKKNITGFMGSQHGYDISSINQTTPSKRKGENVEVAIDPSELERGLDESTLRAKYDAERKAKMGIAEADEDLSDMYAEYASRQAKKQKTQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0P2</accession>
    <name>A0A367K0P2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000436">
        <property type="protein sequence ID" value="RCH95738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0P2"/>
    <dbReference type="STRING" id="86630.A0A367K0P2"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="360" mass="41995" checksum="7BD4E84770B56BF5" modified="2018-11-07" version="1">MYRRRKVVREKKPEIPDTLEGFGYVLKENGEIRSKTTDEPYVFEYLPKDRTYNEQRYKAFINLIGEEVEKKLVEEPFNFQKKIIPVDADPAKDPHSYIYMTPNALTTTDKLILFISGNNTRIGQWSRRVMCDENIYTGSVMDTTRRVREKGYEVIIFNPNGNYWYKNRAWEYPEPHSVNITLVPGSEGPEEHCRYVFDHFIRQVKTRDTSAVHAKAQKLAALTLDWGGHALTQALDVNFDEYKDRFICTAMANSVHSRDMIKDTSLRTWLFDNCVNWTVSQKEKGGIITDPRFGCTCISSNQEIADFTLTECIDDIMNFIFVKMGDIEPEIKDDEDEFENDVTEEQLEELKEHLEITSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0X3</accession>
    <name>A0A367K0X3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000429">
        <property type="protein sequence ID" value="RCH95818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0X3"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021386">
        <property type="entry name" value="SPP41_DUF3020"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11223">
        <property type="entry name" value="DUF3020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="262" mass="30664" checksum="EDD7649257C38BA7" modified="2018-11-07" version="1">MLGEEQAASKIFPCPQCPKLFATRSNLKRHMENPNIHNIPYVRSRDQKRWKGHAKKVISKEETTESNNDRMRKWRAENREKNRQNDLRCRVYRLARQKFGEHDSPEKQGFVREEIARRLGRRMMLERKASNLSQQQYQSYQNKQQQQQQQQTDLIELPFYSGLQQKIELPSIHQMTRYSSSYSPQLPDLSPNLQRRTSSSSTSTSSNSSVCSNSEQLSDRILPSMHTFLSYADKQEGIKYVDSSKILDEFVGVVLNYVDNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1F0</accession>
    <name>A0A367K1F0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_000083</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000408">
        <property type="protein sequence ID" value="RCH96033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K1F0"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05170">
        <property type="entry name" value="PIKKc_SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039414">
        <property type="entry name" value="SMG1_PIKKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF71">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="526"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1195"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="1786"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1559"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1720"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1559"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1579"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1720"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1738"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1748"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH96033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1818" mass="209258" checksum="5C822E20856C62A9" modified="2018-11-07" version="1" fragment="single">RIWPEYSFKNLLVSAKMLCMAWAFDHCDVFVFMLRMLFDYWSSTRFMLNDENGFDIMCCIVSDVMNNWIKLTLESRRLLCDLAQGILTTVCNMEVIQFDPTGHLKPIIHRFISAASIERNKDIKESMLNVITYYCQLCGSADMTAPILRLIQTSINDPYLKIQDASKDLVTSLNPFLISQISKVEDNALLSIQNAIMATPHTGTFRPVHYEIVMKHLGMGKHLVGTNDTAIVDQASTTEWARRLLHHCDAIGNLKNTFLFSELCEDIPKSEIVHLMNNHETVLYYWAMWESARYCILSRLRTPFGNPQQTLAAFERTLNSLITDATELDSNKSISLQYILLLLDRLELQISNATDGCATGTLPAVPRPSLVFFRTNKKTCKDYFSRIRPMMINGAKLVRNEHLLIVHTIKTLKEMEYTIPVNPIPWFKEVNEYMRDLVEVCIRKKYTDMINGLQSWYKKVIRKAYQISSEFKENWTFEGCIGPLQKRSDMANNSTVGSWFQVAAYFAYGRDEQAIKLLSHLKAIVVTDDYGIIRMLNRQAIDFYTCLEDYDSISALLASDPMVADDYIYQSLCAFNSEEKIVKDQQKAFYDMQEYVKTAPLETCIELSRLDTFRQWLIPNLDQNDEITMRLTGKMLNAVKGGISSNITNLMELQLLYTGWEHLVASARDWYKLETENTTCPVYETKRWAHLSTFFESLYNLNEGEHANPTVTQYLGSIQLHTAKIARKYNNISLAEKLIEKAAQFPSTKYNALYERAKIQFNQFEYTQAMDTLNGILSHIVSAPEHKELKSKTYRNIARYLKSSPEDKVSDLLGKLNSNLVKRTATELQSSVEASIDYALEKSIETDTVDGRPWFEYATHHYKQGWRILDELTHSESTMTIVVWAKNQIQANLQSTDQIVDAKQTEQMIIDLLLKYSSSTGSSSISSSQSFMSNLRQLVPFLKPDNETAIVTTLEKLQRIIIDKFQASAQAYFRYLSLDIHIPHHDEMSNTSMVTTATLRLLRILSKYGTALQSVYQEYSDTVRIDLWKRVTPQLFAQLNHPNEFVRQMITKLICRICDEYPRDVIYDVIVSSSSSKTNRDTKQMLNKIANRMMEHNELLWVSTSRMAEEIQKMTILVEEDMMNTIGDLQFEVMRQFNELDKEIVRLDKSVPDEAKKEKTFFELYYNLMKPIISTIDRFIKSIHGFEISERLTPHQQCVVILPTKTKPKKLDFKGSDGKKYSYLFKGHEDLHLDERIMQLLTTTNGLLSENERTALRGMRARTYAVIPLGDRSGMIQWVDEATPLYALFKKWQKRESAAHIMLNNDKPNEAVLHALSLRPTECFANKVYSALKAAGLRVSSNRKHWPKHILKKVYLELLKETPEDLLEKEFYYSSSNAEEWINKTTSFARSLAVTSMIGYIIGLGDRHLDNMLVDFRSGEMIHIDYNVCFEKGRRLRVPELVPYRLTQNLHAALGITGVDGPFRTAAEETLCVLRKHKEVLITLLDAFVYDPLVDWEYEAEEVGHRQMKELQRGLGLIAVHINRQQTQLEQEHQTVARNMTALEESLDRWHLFGSEYMNEEADEEGGEEEEEDSDSEGDDHQPENDPHHSENEATVYRVPMYVLNKVKDRLLCVKSVVSRSRSPLEGILPLLESIIIIETDDDNELRPAQKAAKSVLDTLIAMECQLKKLDKQIDLNQGYESEWTYTQLSDFVKLINKLYAEYASSLKILEEFGPDNKASSNMNVTTTTDELKPSGEVADEETEYEEQNNGTITSQQNKPPKNTHVAKIMKRIRSKLEGVDFGVQHKMSVSEQVSKTIEQATSVDNLCLMYEGWTSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1L8</accession>
    <name>A0A367K1L8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000407">
        <property type="protein sequence ID" value="RCH96039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1L8"/>
    <dbReference type="STRING" id="86630.A0A367K1L8"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="267"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="374" mass="42291" checksum="B5BE3133F8537981" modified="2018-11-07" version="1" fragment="single">MSNKKQSKQSNVLLGLPDGEIEVDNDAYASKIGGIPVWLDPKHPPSAEYCTCHVCGDLMYLLFQSYAPLPESAYHRVIYVWACNKRACMKKEGSFKVVRSHIIDEVYLKAQRQKEEEKRKKEEKLKAAAAANQTGFGQGFQLGDLWGSSAGSFAKAAAKAAEPKPLFGMKPISPFDTKKETVDIADQLSKLSIQSPPVNVSGLPKFPGQYLYIDEEPKEPRYGNIDMSRYKEYLEMEKELLMEVDENSGETWQGETYEKQQLPKGFDKQFKKFTERVELEPSQCVRYEFAGQPLFYSALRPQQQQLIMTPCKYCKGPKVFEFQLMPNVLSILPTTEYASEAEKSVNANNKKSLLDSWSAGMEFGTILAFVCQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2I6</accession>
    <name>A0A367K2I6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000401">
        <property type="protein sequence ID" value="RCH96101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2I6"/>
    <dbReference type="STRING" id="86630.A0A367K2I6"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="303" mass="35760" checksum="AEE26E39720044BE" modified="2018-11-07" version="1">MPLQEKNSRPDRSEIQMSLNSISWPILLAVIPTLGAFVVGNAEDWGDFILILLILYYVYKWITVPWTYYESARSRRISQANKTELEQELRKHELMGLAWVILSPLMAGYTLYYSRRFLNNHDKYMSSFNITVFVLAASVKPLVHVMTLLRERTLFLQNEVSVNESELDRLQKKLDVMEEELYDLRRAFATKKDLGQVTNGIAPNIQQLAKAMKRIEKRDLEFRLWSEEKIMAIDKKVQDIDQYICYTLEQRPRRFIMTCMFFPLNLTFWAMKRMTNLLPKTFLLTFSSSDEVNTKSSKKHLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2V7</accession>
    <name>A0A367K2V7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000363">
        <property type="protein sequence ID" value="RCH96496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2V7"/>
    <dbReference type="STRING" id="86630.A0A367K2V7"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="141" mass="16218" checksum="A094B95E16DD488A" modified="2018-11-07" version="1">MNMLRLFNFPKSTLKPMEWARQLSTTSVCRKSKNVVGDSPEPPVMPAVVGSTILQPKELPNSLNPYLGRSIGNVHNPNIAYRRLNNILMQNNVRKELRANLRYEKPAVARRRKNMERNRKLFGAMVSKKVALIMQMKQRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K557</accession>
    <name>A0A367K557_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ssh4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SSH4_2</name>
        <name evidence="7" type="ORF">CU097_014340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000290">
        <property type="protein sequence ID" value="RCH97289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K557"/>
    <dbReference type="STRING" id="86630.A0A367K557"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="89"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="330" mass="36844" checksum="A172BA9B60A0CED3" modified="2018-11-07" version="1">MPDNPYEPVYAIVIIFVILLFSVTACVGLRVFRKTRFLEQQRQQQQEEEGRPVNDIQLVRIAEAADDETIKTVTNWQQKYPPNTTQFIDVKNDPMIIEKGVLAWKFVEADMTQDSEYESNAAIMDDPYTIVFCQGQGSIMTNLPVPMQELSYWEVKVLQLHEEDSVAIGFATKPYPRWRLPGWHKHSVAYHSNSGAVFVSDSTYGRPYGPPIKEGDVVGVGYLYQSGTIFFTQNGKNLGKALIGFKYPIFPIVGASGPCHVSVNFGLQEFLYIPANQREAAFAPKQGLLPPPPAYGGHIDDTILSDDNSHNENHLTYAAISSSSPPGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5Y4</accession>
    <name>A0A367K5Y4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000258">
        <property type="protein sequence ID" value="RCH97672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5Y4"/>
    <dbReference type="OrthoDB" id="10299027at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016984734" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="11055" checksum="24B2D85BAAC94CFE" modified="2018-11-07" version="1">MQAKLLTLTLFASFLTTGFTAPIYGHLTERESAIIKPIIEGLKIEPDNFEAKCIFQALTRISIAFPEYPIDNLVARLPPRMFHSCIYTEYIDKSKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K688</accession>
    <name>A0A367K688_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DIA4_2</name>
        <name evidence="11" type="ORF">CU097_013596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000260">
        <property type="protein sequence ID" value="RCH97649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K688"/>
    <dbReference type="STRING" id="86630.A0A367K688"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000078">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="157"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH97649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="44755" checksum="2C69BBF1343AC1E0" modified="2018-11-07" version="1">MDQFAVLYQKRLDIYNRLKELNAERNKLSMAVKTAKGQEKQDLIERGKGIKIKAKAYEDDLKEVETELLAKGLMIPNTTHPDVPIGPEENARVLKTVGTPRTGNNLKDHLQITADLNLLDLEQAAITSGSSFYYLQGMGAFLELALINYAMHKAASKGFFGVLTPDIVRTSVAYGCGFQPRSDENSQIYHIQSNNGSQLCLAGTAEIPLAGKFAETTFKEAQLPQKLVGFGHAFRTEDGGRGVEPKGLYRVHQFSKVEFFAVTTAEQSEAMMEEIRSVQEDIFSELGLCFRVLDMPTEELGASAYRKYDIEAWMPGRNSWGEISSTSNCTDYQSRRLGIRYRKAHNENQQLFCHTLNGTAMAVPRVIIAILETFQQEDGTVRIPKVLRKWLPGEPEYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8G4</accession>
    <name>A0A367K8G4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000198">
        <property type="protein sequence ID" value="RCH98419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8G4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="164" mass="18553" checksum="DE775B5FEFE6CA41" modified="2018-11-07" version="1">MEKPRQVRIVSVPSFGVAVNTYETLGRQRGVKSIVAASRSSVEALPGCTEAGKQETIDFALGGFIESLEEQLEWAIHKLEKARPKRREQYRPYIAARIAADARKDMLKERQNRKADLWKAIAIEKGTGDSPEPLELCRSQWQDTQNMLEFGKQQRVQNCHAAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8V7</accession>
    <name>A0A367K8V7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000180">
        <property type="protein sequence ID" value="RCH98663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8V7"/>
    <dbReference type="OrthoDB" id="2258292at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="452" mass="51504" checksum="01E1DC27834E6456" modified="2018-11-07" version="1">MDYQDRFVQLVKDITRLQWVRESLPSHSKYYESLKKKLEKQTHLKVLSENELKEYQQRQDSQSCSINNRLFNRDDNTTLHGKSYSNIIESVRFYDNAIQKLQFEMQQAKEVLQDLNTEKRKLDHLCDELHLLYDQIIIEDPEDATFIFGQHLKRDVEQLAADIPNIKKNIEVYKIAQAKLYEARELIESAMRSLPGAASFMDRQAIASKNNKGNHSGASILGKRPALMVDTIKQADNIAQRSYQLVAEAASICPDVPNIPSSPIQKNETNVVILLTNYRGYRLKVETILRTQVNPRLHGYENQLASAKYHYEQRVIEWIDHQIITLEAYFRANGCLLNDNLNREISMLRMGSRAARAAVASGASERVTVDDVLEISAGEGTALPEYAMVEPNSHSVSSSSNSSSHTDDLDDMNHSRLTPDITSCVNTNSTRIVHNHDLPSYTFHEHPPAYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9H2</accession>
    <name>A0A367K9H2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000169">
        <property type="protein sequence ID" value="RCH98816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9H2"/>
    <dbReference type="OrthoDB" id="10289880at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="8685" checksum="0D7E7FE436FBBB75" modified="2018-11-07" version="1" fragment="single">MAVAHPLDKANSSVPATGCRSDYVVDACGADGQQYKSVISEAKLEKVPKNAIKKDLYRIAVFTKDELCNKGLKGILGFQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9J9</accession>
    <name>A0A367K9J9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000165">
        <property type="protein sequence ID" value="RCH98858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9J9"/>
    <dbReference type="OrthoDB" id="2287558at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="98" mass="11153" checksum="38541DCFF3043474" modified="2018-11-07" version="1">MPLQRNYEAKLNMFNTAFDLSSLGVNRYLLMNYMHMHNEYSFEDLKKSAAKNKTVFANLIRSDGFVADIVLYKGISNNEDVTEQSSDSTFGIQLLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA28</accession>
    <name>A0A367KA28_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000147">
        <property type="protein sequence ID" value="RCH99093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA28"/>
    <dbReference type="OrthoDB" id="2229752at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="369" mass="42029" checksum="5E302DB6A6EC4EB3" modified="2018-11-07" version="1">MIEDRIRLYQEKYKHFMEADTQLRTWINTNKQKGPPLVLKEALPCLRPRMSSISTPLSSNKRKSLPLHSNQEFDIASPTPKASFSTFLKKAMRPSDSTQTRHHNKSSPHYLGRLDNRLSEAPKPRVSASTSSKSHRFFLSSSFNRLSLLKQPVVPPHDPNVARAKVDQTEPPCLDHQGTFSKRKQQGLPAILEYSKNNNSTTKTSKQITRKNTRPQSTIVPYSPSSVFLDRLQRDNLYEERECQMIQPNTYNKTTIYATVGKKGLRGHDNLAPSHCGFKDLDDKEDILNEPRSSKLHRMAFKSSTVGKASARTILDSRNKHDIADQHRSAMTEQSPQKKRISFSLAPSLSSLRFMPQKSSFLKRQSMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBW3</accession>
    <name>A0A367KBW3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000104">
        <property type="protein sequence ID" value="RCH99722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBW3"/>
    <dbReference type="STRING" id="86630.A0A367KBW3"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="32788" checksum="7D612CE6E7079B56" modified="2018-11-07" version="1">MPTREARKLIAVDLDQTLCHTLDSLVEWHNDTYCTNFSVTDFHTLDYWKVWGGTREETYRKIREFYDSSYFDRIKPVKDFALEALKMLKKRHFQLVIITSRQQFIAEKTKKFIDRHYPGIFESIYFCNLYLTEREKLEYISKSKSLICQEIGVDVLIDDSLEHALDCTRLNMNILLYDRQGKYTWNHHDLPPRINRVFNWKQVMAQFPKPSSPLKHCIYSFDDYNIYFNQQYRHTYFQYETIEVEEESDDEPHGDENELSYHFIRDNSVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCX0</accession>
    <name>A0A367KCX0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000085">
        <property type="protein sequence ID" value="RCI00027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCX0"/>
    <dbReference type="OrthoDB" id="2289992at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="105" mass="12451" checksum="87E2272AB65EF140" modified="2018-11-07" version="1">MSTKGLFFQQDKLQDKILSELPKFIPSSSSKNESFRTKEYHISRNDPELYLGDDCDAEYEQMLMNSRFMEWLNKHHPDVLFNRTAASNERLKMILAHFKQEHPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCY1</accession>
    <name>A0A367KCY1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000086">
        <property type="protein sequence ID" value="RCI00001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCY1"/>
    <dbReference type="STRING" id="86630.A0A367KCY1"/>
    <dbReference type="OrthoDB" id="2317955at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="348" mass="40580" checksum="92B1A5935A3DAFC6" modified="2018-11-07" version="1">MQGISDENLRTPRLMLRTYRASDHDQIDHLFYSTYFVLVPEGVKSKLKSPLFWVVWFGFYSYLMAIVPILLADLSVPSWTSTALKVFLTISWFLVSFASVFVFTDRFEAVDQVEQARMNDLSDPEIYYLNWIKEEIELEEESISTSDGKKRVTFDKDAKPATEIKRSQKPIEEQTPSHFWVLTLDNKPCGMIGLAHYRERLYSNRPTQPPAWKLMSAAVLRRYRLPVPEYLNDLYNKMPPSIFAEPHEEKVATLQRLAIRNEFQGSGLSTLLIDRAMVFAHEKGLERVEAVTNELQTKAAEILRVKHGFTLIKKQKKGWFGQYEKTWSCNVNDWMESHRKEAQTFMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD17</accession>
    <name>A0A367KD17_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000087">
        <property type="protein sequence ID" value="RCH99989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD17"/>
    <dbReference type="STRING" id="86630.A0A367KD17"/>
    <dbReference type="OrthoDB" id="2286142at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="477"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="62029" checksum="46E926FAF65B9FE4" modified="2018-11-07" version="1">MDAYQPYSFFLNVQEEDGVLVGDLKISVGIIIKREALRLHPDYNQLKYDERDIVDCLTVKTFSLGLNPVLDLSNLDGSQEKLFDSKIWKVLREKYDQAFHDNAQVVSKDEGKLEEIEKFAKANLRDACAYAYKNEMKSTSADEADLFAILEMLEYHGYIFDKDIGITEADLTVKMWGCLLEKLFRQTALRCKCCEFAGDSSETTDSPGFKVDLRVVRDTLLRRNKEADAGNMEMARMDASVIKTCSYKTKLLIESKCVLDRLVRASPHWAMDVAVPALQIIENKAVLLSMRLVAPGLYVAVKEVAATIPGRVSYVKDFRQAIHLLFKFKRASFDVAKVYLQGMKTILLREHNWNEPKLSFQGKTTARSEENDKVMYDVLLDEASGHILKLSEGAIKYVGPLSTPVAQEIVIDANVVEAEDLLEDAADEDEEEESIDLTSSRGWTAGEAYIDSRLSGSGEGFASLNSRLIMNNGRYACPLDYFLFFLPVDHFYSIIHSTNLHARNLDHWEDITFHEYLMRIALLTAMTVVRHGDRKAYWRQGQSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE46</accession>
    <name>A0A367KE46_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000057">
        <property type="protein sequence ID" value="RCI00494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE46"/>
    <dbReference type="STRING" id="86630.A0A367KE46"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62558" checksum="9D20E25380CEEA8B" modified="2018-11-07" version="1">MPATGYVFSTLDDDSIVPSPTSKTQAHSTSVMDHQNTTTTLRSTKKPLADDEKEELELESFMDKKDILLDQEQQQEVLAKKDYGNFTLLVILYLLQGVPVGLCFGSIPFLLKAKLSYSQIAIFSLSSWPYSLKLLWSPIVDAVYSHNLGRRKSWIIPIQILTGILFYILGNNIDAMMSSEHVPIYILTYSFLATIFFCATQDIAVDGWALTLLSKESLSYASTAQTIGLNCGYFLSFTVFLSFNSAEFSNKYLRSIPKEYGVLGLGDYMRFWAVIYMLVTAYLVVYKKETNVKDEEAQLGIRGVYVTIWKICKLPHMRSYIVVLLIAKIGFICHEAVTSLKLLEKGFSREDLALSVLLDFPLQIFFGYYAAKWSNGPRPLKPWLYAFYGRLACSALGMLTVAYYPQGRPVGMIYFGIIMASTVLSSFMSTVQFVSISAFMTSIADPLIGGTYMTLLNTFSNFGGTWPKFFVLEAVDYFTVNTCSIPNESGEYVSCVEESGKEWCKEAGGSCIIHKDGYYVVGTLCVLLGLFCLMFYIKPVIKKLEKYPKSMWRLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE75</accession>
    <name>A0A367KE75_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_015636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000078">
        <property type="protein sequence ID" value="RCI00142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE75"/>
    <dbReference type="STRING" id="86630.A0A367KE75"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000003">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="288" mass="32147" checksum="553C3ECE9E47CC46" modified="2018-11-07" version="1">MVTIATNFLFLGKNSNLVQVFLIPLDYVTMVFALWNFTVVGLVSIFWKGPLWLQQIYLTVMSSLMAFSLTGLEQWTTWILLGLLAIWDLIAVLCPFGPLRLLIESSKNQQREVPALLYSVNAVWLMMASPGEHFNQPSPSARNSREYQSTGHPITNSGQRMSHDGFMQLHDESHGSILTTVRSTVTTETENKDEEDVERNGLKLGLGDFVFYSVLVARAAMYDWITTVCCTIAVLTGLTATIFLLAIYKKALPALPISIAFGILFYFVAKTVLVPYICELVVFGMIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEV3</accession>
    <name>A0A367KEV3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000043">
        <property type="protein sequence ID" value="RCI00736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEV3"/>
    <dbReference type="STRING" id="86630.A0A367KEV3"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="359" mass="40884" checksum="44A000E1524A5933" modified="2018-11-07" version="1">MTLCVIDLSYSAITTMPHGLKLSKMFPKSEYGALKGVTPFWQSASQPSDESDVSLLTNVSPESWKELVALAENYNGPISATLHISKQAHKDILNAIEQEYRSKPSLYQNVDIHLIETSGHNSISVLLPMNAERNIARVYARTNYVCDTPSSVILPTDLRRTIHTYTKQMQLGDMLVVPTFEIQQQVISANDIPRTKKEVLGLVNEGKLGLYDAQFKLNEGPTDLEKWKKAKDVYKVENYTIDYEPLVIQSKTVQPWCSERFVDKRSACLLSSYLAGNDFLVLPSDFAIYKPSARKHLVSDLDRVIEKRLYSKFYWEECVYHARELDSMGLWKTSKSNHIRQQCSRIIQNWGKGLIGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFP1</accession>
    <name>A0A367KFP1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PCBD1_1</name>
        <name evidence="6" type="ORF">CU097_003426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000029">
        <property type="protein sequence ID" value="RCI00999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFP1"/>
    <dbReference type="STRING" id="86630.A0A367KFP1"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00914">
        <property type="entry name" value="PCD_DCoH_subfamily_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.20:FF:000001">
        <property type="entry name" value="Pterin-4-alpha-carbinolamine dehydratase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002018">
        <property type="entry name" value="PRK00823.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002020">
        <property type="entry name" value="PRK00823.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="98" mass="11368" checksum="0A026406078393AC" modified="2018-11-07" version="1">MAVVKLTQEERDTLLSPLLSSGWKLVDNRDAIIKEYTFTDFNQAFGFMTRVALKADKMDHHPEWFNVYNRVQVTLSTHDCQGLSKRDIELAKFCDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFP3</accession>
    <name>A0A367KFP3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000029">
        <property type="protein sequence ID" value="RCI01008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFP3"/>
    <dbReference type="OrthoDB" id="2278238at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="153" mass="17623" checksum="66A96E6D405AE64F" modified="2018-11-07" version="1">MSCQSCSGCFTGSSCSTKETTAQDKTRFEDLLERANSEPEEYQKEHSHVIPTIIVQLSKNVYASQTVLFKAYDLLERPQFIQLSKYLHDYKLTGEHIAWSDEYVKGDIKQLLDILQQKEERSKLLQYCDEQAEIYELFTNLPSGTVRRIGKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG73</accession>
    <name>A0A367KG73_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycogenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000022">
        <property type="protein sequence ID" value="RCI01177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG73"/>
    <dbReference type="STRING" id="86630.A0A367KG73"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34656" checksum="311053F3229F9C00" modified="2018-11-07" version="1">MVTKHKAAWAVVITNSNDYIKGVVTMKYALHKVHNSRYPLLILYTSHVKPEIVEMLKNIGCLVKNIDAIYPSGKVDYRFEQFSEVWTKLAVWNQTEYDRLVLLDADMLPVKNMDELMSLELPQGWVAASYACTCNPLKIKQYPPHWIPENCAYTGCQSIQPSPISDRADYFNSGLIVLSPNKDKYDNMINYLNSMEDLTVYPFADQDFLNEIFKNKWKPISYVYNALKTLQWAHKPIWDMNQVKNIHFIMAKPWDLDINQLSDLENTYRALYTLWWNYYSEARISIGISKSLDRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGQ2</accession>
    <name>A0A367KGQ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGQ2"/>
    <dbReference type="STRING" id="86630.A0A367KGQ2"/>
    <dbReference type="OrthoDB" id="5514950at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="63533" checksum="1B8AC803A49A3A47" modified="2018-11-07" version="1">MTTISISLLKATGLPKQAISPFLKLAESSSVLLIIKTWLLSPNKYPTFWQQFYAYGQPIQSIKNRGSLGIALLYDRTTLPAATIRDDLSLDSYHKFMILSFQVVAPSLRTNASKRILWHLNKLEDDQLRSQYLEHFSHLTKDLMPTNIPSFDNRSSAATYIEQFNRILCQAIYQSLYLVCGRHTRRADNFQQQFWTRELQNIFDLKEYYYRNLTSIFRKLLERSIHHFLMGHSPPLGIAQGEFRESRGSLDQALCLAEICNILRRHYRITPVLAFLDIKSAYETVDRPTKADMPILLKSCEDHSYKLRYRWNPSKCVISDPTQPSSSYTLYGETIPKQTSFPYLGIPFRPGSYLDAVALVNQNKAKALATMNQLSTIDVHPKGFSPFLGIRFYGHIVRAQLKYGLATAKITTFLSKQLEDAQNACLRRIFGGSHTSSTTIMLHMSKLPTMQKRAYALQSQFPLRSLTLPEDALLHYLLPFIRQPRSHSQWYKLSRSPIWKRCSPDPKSLDRRSLQLIQREYRQDSLNNKRSTHASVLLMHCRPTISLDPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGV4</accession>
    <name>A0A367KGV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCDC174 alpha/beta GRSR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000011">
        <property type="protein sequence ID" value="RCI01407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGV4"/>
    <dbReference type="STRING" id="86630.A0A367KGV4"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="4">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="32142" checksum="4EAFF75A10F92F12" modified="2018-11-07" version="1" fragment="single">PEQKKTVWTKQNKGVDARNAKDKYIEEVESNVLARSREQLEKKAKIYEAMRSGHIQQEYSEYDDDEKAPLIDFDKKYLQERQLEEIREETERKLKKRRQEKEAEDVDDPWVEYEDEFGRTRTVRQSQLPKLLPEEKTKSEEDDYIPRYDYEIGDELADISHINHYDADAEIRTKGVGFYRFSKDEEEREEQMAKLNKLRQETENARKSAISAAAKRQQMMARNAEKIRARKAALQARKQHPLKQEPNNVSIPDINEESVASFLQSMRKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJY8</accession>
    <name>A0A367IJY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005527">
        <property type="protein sequence ID" value="RCH77946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJY8"/>
    <dbReference type="STRING" id="86630.A0A367IJY8"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="181" mass="20894" checksum="5D35CF57AB03233B" modified="2018-11-07" version="1" fragment="single">FIRILFGEIEYRPNHLPVTITQDATVHHPCIQIEPFLEDIDSVHRLWKAVFLPTWPLSLNNFSRVLSRLQQPAHFVVHSKEGEVIGFAATQLIEKHGQIALLMVHPDHRQRGIGSALLEECMKTLKRRGAKEIQLGSTYPRFFCGLPEDQERNIAFFEHHGFKFGNNVWDLMGDLSQYEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKH9</accession>
    <name>A0A367IKH9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005473">
        <property type="protein sequence ID" value="RCH78031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKH9"/>
    <dbReference type="STRING" id="86630.A0A367IKH9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7281" checksum="F9FB46F7837DDA71" modified="2018-11-07" version="1" fragment="single">MALVDTGADIFFISKQIVDKFKLNVNPTKGLLLLADKDRLSKRLGVTDKMNVGYKGQTIVHEFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILT7</accession>
    <name>A0A367ILT7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005045">
        <property type="protein sequence ID" value="RCH78593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILT7"/>
    <dbReference type="STRING" id="86630.A0A367ILT7"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH78593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="162" mass="18929" checksum="0E1836B007FAB8D0" modified="2018-11-07" version="1" fragment="single">SIYSTFISPWSDTQSLPGLNVEPGYYLPPCYRHVQATPPAHQRMRTFSDEILFYVFYCMPKDIAQEAAAQELYARNWRYHKELGLWLTKETDENGRPVQSFRRTSPNGLDRGVYVFFDPTTWQKVKREWTLSWDALEERSQPSQQQQGPSNPSSSNSNRVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INK3</accession>
    <name>A0A367INK3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004605">
        <property type="protein sequence ID" value="RCH79264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INK3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9417" checksum="31CC8D77B3B19E23" modified="2018-11-07" version="1" fragment="single">MVLCSAIKGITQSVIADIEKEYSGRSSNEMTVEAHTRQVRQHPPSTYWIACGPLMIINTTSAGGAVPAERSSAYRKMLTIYTANGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQ14</accession>
    <name>A0A367IQ14_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004291">
        <property type="protein sequence ID" value="RCH79778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQ14"/>
    <dbReference type="OrthoDB" id="10615964at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="146" mass="16613" checksum="0676D9BBF4AC4299" modified="2018-11-07" version="1" fragment="single">MLADKIFEDHQQYLNDIAGIDFTRGRKERAGWKNPCEMFCGKAEIGIIRAVFSRYFTATNYKISYLHGGKCKDHTTIRGSMHKKKALELGIKDYEEGYIAVKVSFANIPFTTLIPELSHVLAELKHKCVVLHDLDIAVDCAYISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS16</accession>
    <name>A0A367IS16_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003889">
        <property type="protein sequence ID" value="RCH80490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS16"/>
    <dbReference type="STRING" id="86630.A0A367IS16"/>
    <dbReference type="OrthoDB" id="10299545at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="54" mass="6130" checksum="8FEA49806A409E63" modified="2018-11-07" version="1" fragment="single">MTNAISKSQQNEIKLLLSQNKTYAEIMERIPGLKKSTLGRYANKFYPNRVPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISY4</accession>
    <name>A0A367ISY4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PRE2</name>
        <name evidence="12" type="ORF">CU097_003652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003727">
        <property type="protein sequence ID" value="RCH80804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISY4"/>
    <dbReference type="STRING" id="86630.A0A367ISY4"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH80804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="277" mass="30752" checksum="79115495CB133A15" modified="2018-11-07" version="1">MHKFVSRYSSSPLSLPQEESLGQLCGKWDAAQELAFPTFDVPAVHNPVDFLRNVTDEESPEYKIKIQHGTTTLAFQFQGGVVVAVDSRATMGNYIASQTVKKVIEINPYLLGTLAGGAADCQYWERELGRRCRLHELRNKERISVAAASKLLANMVYSYKGMGLSMGTMVTGWDKTGPNLFYVDSDGSRLKGDIFSVGSGSTFAYGVLDSGYDFDLSVKDALELGRRSIYHATHRDAMSGGSVNLYHVTENGWEYHGNHDVGQLHWDYQDENAKSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITF5</accession>
    <name>A0A367ITF5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003656">
        <property type="protein sequence ID" value="RCH80948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITF5"/>
    <dbReference type="OrthoDB" id="2284562at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="282" mass="33191" checksum="697FCBD4286CFBB3" modified="2018-11-07" version="1">MQALQFICDQVQDLPVTERKATFNDLLATLQQLTVERILSHDLPTDAEHDYARFSLEVRSRYLHTASIRVLHDPRYRRRSTKYPLAPFLPRSFTWIWRMHCSQGVDENQLIRTRFASYFGQLFEVTSLYLESNLDGTFEECVREALVSGNAQDLLVLCLAAGRPVEVEEMCMMVYEAGEQFRAYLDTMQTDPTPQQELRMQHDNELRQQRLLQRQQEQEQVGGNDVVDEIEEDMIPDWLIPDRYKVHKDTVLRLKLMNDLFNKGWRWFTVPKSSHPHLVNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU34</accession>
    <name>A0A367IU34_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003543">
        <property type="protein sequence ID" value="RCH81188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU34"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="253" mass="28074" checksum="F59CD00EF4B82149" modified="2018-11-07" version="1">MQCEQQVIAEPVVADVKKEEQHDTPIKPEEQTIASLQQEQPMVPLQQQQQQQQPLQTTLATTEVPVSAPDTSTTTATATTTATELIPPESTISTITTFEEIQKQLKSTLDHIEQRNMVSGFQTLSKATAAVVEHCEQLGLTSDDHPYNAIDREQFWAGLNNCWLYALAQRQEPSSDAERLTDQHLYNLRDMVVTWADKLERYGLVDYEMGWWEADILAAIDGILAMNYAAAQAAAQTVVAQAAAALFGDEVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVW3</accession>
    <name>A0A367IVW3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003267">
        <property type="protein sequence ID" value="RCH81817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVW3"/>
    <dbReference type="STRING" id="86630.A0A367IVW3"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="56" mass="6185" checksum="E93A52090154C6B7" modified="2018-11-07" version="1" fragment="single">MAKERSAISKSMKKRVSGTHVSGLSTSKSAKKKESGLKFGQLSRKQKQDLQDYGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWC0</accession>
    <name>A0A367IWC0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003216">
        <property type="protein sequence ID" value="RCH81942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWC0"/>
    <dbReference type="OrthoDB" id="2257639at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="163" mass="18776" checksum="57D9BE73B1E53CB6" modified="2018-11-07" version="1">MTLVLEQSIKPKKTTWKWWQSNKQMNLSMDISDENDSITPSSLVPQRSIHSRESEDIASTTSIKSKPWVFRREEDSALAEQEEEEELQNVKDDMIMPENSIEGNGSSKNIQYSPKLHLVPSITSSTIPVINYSLDEPRRKSIDTFFFPGLRARFGKWVSKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYE3</accession>
    <name>A0A367IYE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002922">
        <property type="protein sequence ID" value="RCH82708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYE3"/>
    <dbReference type="STRING" id="86630.A0A367IYE3"/>
    <dbReference type="OrthoDB" id="2267579at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15585" checksum="CCBE2A27AB5161D5" modified="2018-11-07" version="1">MVSVIGKGADRLRTAGRGTSELYNEIRYIFEEGGDQQTMSTILEKARKLAEYYLATGKELDRDAKDLSTKAFRLPGSLKYLEDDDEDDNKDLFLSLDVIEKIQKTRFEESVIKRSRYSSRPQGGFNGRGLFGIMKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYT0</accession>
    <name>A0A367IYT0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_003565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002899">
        <property type="protein sequence ID" value="RCH82769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYT0"/>
    <dbReference type="STRING" id="86630.A0A367IYT0"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH82769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="455" mass="49459" checksum="200571429DD70101" modified="2018-11-07" version="1">MITYSIIVPILPFTIDAIERGRSPNNPGYDPYHSELHDPGGVSKQSGALLALFSVGLIAGSLGFGYLGDRLKHRQGLMLVGILGLIGSTLLFMFSEYYWELLIARFLQGISDACVWTLGMCLISDTFPIEELGTQMGRVMTFHSIGMVAGAPIGALYQTRGYKAPFIFCVALAGVDLVLRLFLVERKNNPPEWFKKQNEQRIEESRTATIDSSVPEKKDTVSYWMLLKQHRLLAGMLMAFSNGTLLGVLESTLNVRLASEWGLNSGQIGVVFIAAVAPTFVASPLAGYLADKLGAKVVVIPTWIIGSVATILMGVPNKSTAGGIAPLIILTVIQGFCVAAFLTPVLSEMGHVVQSLNPDGSDDGQGRSYALFNVAFALGGIVGPFLGGYLYKAIGFFWVNVVMGCFLLVCAPYVFVFIGERGKFIVRQKRNEDEPIRSEDTEVYAAKTEMKPMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZS7</accession>
    <name>A0A367IZS7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002782">
        <property type="protein sequence ID" value="RCH83079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZS7"/>
    <dbReference type="STRING" id="86630.A0A367IZS7"/>
    <dbReference type="OrthoDB" id="2238957at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="875" mass="97780" checksum="C537D8EE50131E88" modified="2018-11-07" version="1">MADVRKETDSNEEQTKSTIESLKSRIIATNKLYKYLTSAKQDAEEKAKKIASLNNSLEEALKMIDTRDKEYKSLETKYNQLLASSGDDPVELQNKIQSLQQTILTLTQEKQKAESAVSSNTIYIKQLEAQCESLRETSGKKTQGSAKQNAEIKRLQQELMTKTQEVQELKEQLEEEREQKDKVEDELMELQINHEMVNTKQKETNDELQEFKKKYETLDNEFNQLKDAYGKLQTKLIMAEKAATEATAKAEAASHASQPIYNDSSLKEQLQAAKAELKLSKFENEFLRNQIKSMYINQEKNGSQLSDEETTTTTHDLSFSSAASTPVQPSKPIQKRPLVTSQNKSPASSAIPSALPSSLVNSNETSSKTQQALPSPVRKPLLKSTHTKSPVVQPTTKPLSLSQTTTPPTPLTSSTSIPKEQIDKTAYRVTGLIPPPPIIPPTPTKLTTSNSSRSKLEKFANSRNPSKLIGSNPTPVSKKRPSTTVDVSELPEPKKQKQDNKYLKIADQSVNTKYTLPSHIDLSHELESILSEIDACYEKIKSAANPSELSDTTFGIPGGLRISVPGTVDKREKLYAWLLWALVHENTEAYDKMLKALSAIVAERIQSTKPQTTLMRYIRLVSILCKEHGDLSRMRVVCFDIVRYSKCVANTTACLLNVACIYNESISLIGQQQRQPWELQTVICSAVAHMVNASHNKTVKETYSRIVTLCQWSSPHDIVPLQSVISQVAITMKSPDFKELYSKNKAAFKQQTFCIIKSLELAFSTINNWTTIYNDFIRNTLWPMIGDEVLDGLCLELLGVLGSLGVGEGAAGHDKSGVMVLLHKLMSVLKADLSPDMKHLQYSALHGAILLSRNKPEYLKSIQKWLDDNNNKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J045</accession>
    <name>A0A367J045_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor cwc26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CWC26</name>
        <name evidence="4" type="ORF">CU097_007122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002704">
        <property type="protein sequence ID" value="RCH83315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J045"/>
    <dbReference type="STRING" id="86630.A0A367J045"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="337" mass="38894" checksum="3DF5B9431874D57E" modified="2018-11-07" version="1">MDKIKQLDNDEIIRQKYLARGPGDAATKAYIVAKYLDDSTRKKKKKKKSSTTAPKLGNIGIIDEDAFGWNTEDKKEDTEAKELEIEAEFVTKGDPFHGAVNNWQTVREGVRRQEAETLEDMDEDDAPVVVESDDVPRMSNGQRAGVLTKEEIKAEAERARLAEKRAMERLKREHQEEAAETVYRDVSGRKVDIKVKKAEEARRRREEIEKEAKRMEWGKGLVQRRAAEEEKRRLMEEKDKPLARYADDVELNQELKEKERWNDPAAGFLTKKSTSKGKRLVRPTYKGAWKPNRFMIPPGYRWDGVDRSTGFEDNLLLQKNQAKSRAAEAHAWSTEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J057</accession>
    <name>A0A367J057_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002703">
        <property type="protein sequence ID" value="RCH83317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J057"/>
    <dbReference type="STRING" id="86630.A0A367J057"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="60296" checksum="407E6981B6438D34" modified="2018-11-07" version="1">MATEENKEYYTTAYTTTTTVATAMTTEEKVETGSDGILSHEDGLVRDDTIIASSIEINEKSDITTAQEYDENGNKRNFTISQTEKRLVRKLDFIYVMPFVAILNFLQFFDKSTLNYAVPMGIQQSTHLTGSQFSWLTSIFYLGYLIFQIPGTFLIQKLPLNKYVGTLIVLWGLVLLLTFLARNFSQLAALRFLLGFFEAGIYPACVMLISTLYRRNEQSGRIGIVYICNGLAMIIGGFISYGVAYMHDNGLEPWQWIMIILGAITMAFGVVCFFFMVDSPKSKVLRLSAEEERIVEERTEDNAVVRTRNFKISHIYESLKEPRYYCLLICSLLITLQNSALGSFNTTITAGFGFSKLQSILLTIPSGASTCIFILIGVYFNRRYGHTLYLASLFLIVAIIGLILLLVIPAFKVKLLGLILVWSYCASFVMLLTVVANNVAGYTKKVFYSSSIMIFYTLGNFIGPFMMVDSQKPLYIGGMIGFIAADFICILLYMYLRWTMIRENRRRLALPAKMEVVDDMTDIENKNYIYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0K3</accession>
    <name>A0A367J0K3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002652">
        <property type="protein sequence ID" value="RCH83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0K3"/>
    <dbReference type="OrthoDB" id="10275617at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016768369" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9570" checksum="98A75F9C934848A6" modified="2018-11-07" version="1">MKHFATAFVICLVFITLTQARPIDGVTTNEVSGKGHSHNFKHTKTTVYTVGSDDGTTMEFTDADVANFPELEQVVTENNQAYQSDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0S4</accession>
    <name>A0A367J0S4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002637">
        <property type="protein sequence ID" value="RCH83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0S4"/>
    <dbReference type="STRING" id="86630.A0A367J0S4"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="245"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="60627" checksum="11790000CEBAF085" modified="2018-11-07" version="1">MSKNLSINTTPKDINKRYSSKSYALQDENTSPQRKQLPGFIEENDEEEEDEEEEEEEEEEEGSDFSSSPSIPDENINFDLVYTLHTFEATVDGQVSVKKGDALTLLDDSNSYWWLIKDLKTSEVGYIPAENIETPFERLARLNKHRNVEITSLGHAAHYIKCNTKQTRSRQKKVVLSPSVKVQLEIILADDENEETTYEEWNEELIDNVDDAESEEEKEGQPDVEEEEVKENETERTSIEDASVSSKVLRVYAGKLNVGASYHSIRVTENMNTSELLSKAMEKFHIPQIDKHHKRSSSSVEYYLSIRNRDGDEITLEPEDKPYSIYESLNAHLTTPMPSLSEQFKLSGTLKKKKKRQHDVQFLLHKRIKRMNEGGLVHIKLSLLAQKAASDKGNAFFQSWLMKKKKKAASVAERIDKVVAVHDTITIAQLTQVAFEKFHIVPHESHSYRLLLHTKNRDTLLNSELILAQVLKELGNDEEKQFILHNFSSTATVTQNNNKSNNSNSKSLVFPSDVLGSELPAMSIKQNISTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J561</accession>
    <name>A0A367J561_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002193">
        <property type="protein sequence ID" value="RCH85063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J561"/>
    <dbReference type="STRING" id="86630.A0A367J561"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11965" checksum="2CC08BFB49FB1223" modified="2018-11-07" version="1" fragment="single">MSKISIQNDRGEIIVGILEKKEAIDLGRTRPRLMLITHGVLGHKDYLFHRLLAQELPYSSFRFDFRGNGESTGEPGYANMKEDVEDIHTVAEYFENQLGYEIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6W2</accession>
    <name>A0A367J6W2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01002033">
        <property type="protein sequence ID" value="RCH85702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6W2"/>
    <dbReference type="STRING" id="86630.A0A367J6W2"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH85702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1083" mass="124286" checksum="72162316A6AA44CD" modified="2018-11-07" version="1">MSENTSEADQIRLKRLAKLQQQQQQQQQQQQQQQQQQQQQQQQPLKATSSLNKPVLPTLEEATPIKKPTPKKTVISPTPTAKVEKPTPSVNTTTIPAKPAKSFEDWQNDVIARILQVTLKPESMYQQGKCVYLRGLVEELIEEQEPHPDKLSQKHLDRIIVARLSLDPNEPHEELPKDIADTLNITHFDYLLNCWKQAYDIRKNTLIRSKGLEKAVLDQRLSVLDSVRQLVISYSGLVIQMPDMFPQIQSHNLGPAQLIPRIKAGLDTADGLPSEYINELAARFKEDGLDLILGPVLASISTEIGRCTIIDNYKTLIQAITCLSENKIIASMITCLPEFKPENVTAKNIEDLSLLGPYFKLSAYPDPTNKVAETYFQNAENRNSADLESCKNGLRGSVSNIQKTMFNVCNSIVRANPEARDRLLDYFSYVIQLNEKRAQMQVDPQTVASDGFMHNITGVLLMFSDPFLDVRASKIDKIDSTYFRTSKRINVTEDTKINATKEQSDAYYGEQQELKNHNFITECFFLTLAFMHYGPIRAIVNYGEFIREFGEIKKQAERAQQEALRAANTPQAVLADFVSKRMKAKLEQMTAYRLAYETMILDPSFLAEAIRFYDLVMAWLVRIVDPKHKHPWETVHLPLPEQVPENFAMLPEWIIEDIVEFYIFIGKHGYETQVMHQCPHDQLAAFILTFLRNTKYVKNPYLKAKLVEVLFFFTFPIARGIPGELEAILNSHPLSLEHLVPSLMNFYVEVEQTGASSQFYDKFNIRYNISHIMKTLWNHPAHRAKLREASKNSDTFTRFVNMLMSDVTYLMDESLSKLAEIHQIQTEMSNQAAWEAQTPQYRQEREGNLRSLERQAQSYVALGNETVHMLNYMTAEVVQPFLVNEIVDRLAAMLDYNLVQLVGPKCTELKVKNPERYHFNPRKLLSEIIDIYLHLNTDTFVEAVARDGRSYKKEYFSRAASILQKHGLKPLDDIHALEQFVNRVERAVQTGVEEEEEMGEVPDEFLDPIFFTLMEDPVLLPTSNVIVDRSTIRAHLLGDTRDPFNRMPLSMDMIQPATELKEKIASWKDEQKSKRGEKMDTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7W1</accession>
    <name>A0A367J7W1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001963">
        <property type="protein sequence ID" value="RCH86006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7W1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="26766" checksum="4B2734BBE28A73D6" modified="2018-11-07" version="1">MVPYATRKYYLDYSKYYRESGYTKRTIQKYQNGIKEVCLDMYDGFGERYLIENLFWKCKGIEKFTYKKATISDFESEFPDPRCILSSSLTALKLIAKHLRPEALPAYSRAFPELRNLPIETIYRLFDSLSFIVNMSKTKINHLKVYFDIGLPIKKDKLHKPVLLEILSKKSCQKQFLANITLSNQLEEFSMATNKEYGYIIAIKCTSIDFISISFNEMHILKEYPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J864</accession>
    <name>A0A367J864_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL15_4</name>
        <name evidence="5" type="ORF">CU097_010236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001960">
        <property type="protein sequence ID" value="RCH86019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J864"/>
    <dbReference type="STRING" id="86630.A0A367J864"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="70" mass="8471" checksum="36AC3504AC2CB9A5" modified="2018-11-07" version="1" fragment="single">MGAYKYLEELARKKQSDVSRFLLRVRCWEYRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRIRVRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J980</accession>
    <name>A0A367J980_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001854">
        <property type="protein sequence ID" value="RCH86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J980"/>
    <dbReference type="STRING" id="86630.A0A367J980"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56576" checksum="DA9AD530BF0A4EF0" modified="2018-11-07" version="1">MKVVRSILFYGGDGSINPSDDNSTHYLSDLAILPLHSPFSVTSPPWSTASGLQNSLGGPSVRAHIAFTGGLNGDNMLIIGGVMPNQMPIDEEPTAYTYDIDLGRWNSFSLPRENRLNRQGAGCTVTKNGTAYIWGGKRSARVPIHVMNLPANIYRFDSVHPENSSFIPLTVNPPLRYAHTQTLIANDRIVILGGFDGLTGNAISLSDVWVFDIKASNWTHITAELDRDNKPENRSSHSQVLMPDGYSILIYGGYDGYHVYNDVAVLDTRTWKWTVKNTNAALQGRADHTDVNNIIKATLVGTNMIVAFGFSGVSTSLTVMSDIEVLDINTWSWTSVYTPSGLPFSDDTDSGTTQRTDDTSSYPSLAIIAGAVTGGLVVFILILIAFYLFNVYQQRTRSSSSSVARVHSLPSYITISEIKRHDNSPKRSDTIGTSTTVVANDTSPVTVLPSPWKDTQEWVYSSIPKVVHKPDDTCSQRQNDLEVDRDQEIEEKEYFDRQEFILLSDEVCQQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9W8</accession>
    <name>A0A367J9W8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001806">
        <property type="protein sequence ID" value="RCH86728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9W8"/>
    <dbReference type="OrthoDB" id="2289866at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="246" mass="27999" checksum="C849F6806A4B51CE" modified="2018-11-07" version="1">MQQDIYQGQIPPAGYVDTPNIYRICGKFHVGYSGPVACVLWIVINLYAAVLSFQGRSPIYSYLNSTALFIQGVVCVIFVLSALVSLYIFSVGIPEALKISHRMTWTIVIVFLIDYFANMVVFGVQKNQFNGWCISKARKSADESLSIVQADGSNLQVLYSPTVSGSDLYNCTRLWENELKFGVVIFVILFVFYVHIAFCFWNFTQEKLLIRAEMMRYHFSNPYVNTTINPMHMMSNMKPSKNKTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAL1</accession>
    <name>A0A367JAL1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001761">
        <property type="protein sequence ID" value="RCH86950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAL1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="73" mass="8534" checksum="00075804106E389A" modified="2018-11-07" version="1" fragment="single">MNNDRLKNPKDHFYQTPFKDWSTITILNSYLGTYKIQSLEEMCDLLMFDLQQKWSEISAAATTTPEGPVKFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAS3</accession>
    <name>A0A367JAS3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotic expression up-regulated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001786">
        <property type="protein sequence ID" value="RCH86831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAS3"/>
    <dbReference type="STRING" id="86630.A0A367JAS3"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016695012" description="Meiotic expression up-regulated protein 10" evidence="6">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="42080" checksum="E6DC620AB262B4AA" modified="2018-11-07" version="1">MKINTTLGLLASTILLWVQQTSAASCQGELKVTTQLDMDKARSCKTYNGNIVVDNTGVGSLTLNGVELLEGDLIVTSNDALQSFSMPKLQGVNGELKFANNKILGSLDMRELYAVRSLEVSVHPALNELKFPKGLTEAEKITITDTTVTKVDGLKMNSARDIYISNNIYLKTFALPNVTTLNNVLISANSPTLQVDLSKIQGMHEATFRNVAGLNLDGLVKVAGDMSFISNSFETLDLPSVTEILGTLTLQDNLQLNNLSMAKLSHLGGALSVSGNTKLASIQAFANLQQVDGTLDIIGGFDEMQLPAISDIRGGLNVQTSSSTFSCDAMNKLKNGVIKGNTFTCKSAVAHPKSGIRGGKNGKGGSSDSDNFEGAASAINVGYYLAVGAVLTTLFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB22</accession>
    <name>A0A367JB22_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osmotin, thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001742">
        <property type="protein sequence ID" value="RCH87039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB22"/>
    <dbReference type="STRING" id="86630.A0A367JB22"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000004">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016628652" description="Osmotin, thaumatin-like protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="23561" checksum="CC604D8501B8DC1C" modified="2018-11-07" version="1">MYKLVFLLCFLVHTLTAGKTITVKNNCKKVVSVGTLTNGKGSALPEKTADLPPGGSTQFTESDTWGGRVWGRYQCSGSSSNDATACGNPGAVNPATLAEFLFKGSNGQDYYDISLVDGYNLQMTISPDGGNPSSGYSCGSPQCVTPDCPDEFAVKDGTGNTIACKSACSATGKPEDCCTGSYNSPDACKAGSAANSIKSACPDAYSFAYDDQTSTFSCSATGYTVTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCV1</accession>
    <name>A0A367JCV1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_008888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001595">
        <property type="protein sequence ID" value="RCH87764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCV1"/>
    <dbReference type="STRING" id="86630.A0A367JCV1"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF150">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH87764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="396" mass="45037" checksum="7D3977F4A29A0EDB" modified="2018-11-07" version="1">MSNSPSPSTSKRKSHIVVETLGATTSETEEGLRKINNYLLKKEIGRGAFGTVHLGIDEITKKEYAIKEFSKSRLRKKEQMDQFRRSGPRRRLAGLGVNRQQVVKGTENPLDLVRGEIAILKKLDHPHVVRLFEVLDDPSGDSLYMVFEMMHKGVLMNIEADQVATPYSVDMARRYFKEMMLGIEYLHANEIVHRDIKPDNLLISKDDVLKIVDFGVSEMFVKGNDRLKKSAGSPAFMAPELCVARHGEVSGKAADIWSMGVTLYCLIYGKTPFMSSNIMELYEQIKEAPIEHGDDIDANLRDLFERILDRNPETRITMKELRNHPWVTNNGTETMISEEDNCNIVSDVTDEEMKNAIKSIASLYVVMKAVSKFKRHSRSLSQQQAELHEKLQDLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD27</accession>
    <name>A0A367JD27_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001575">
        <property type="protein sequence ID" value="RCH87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD27"/>
    <dbReference type="OrthoDB" id="2283572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="158" mass="18223" checksum="4E031E2B12A72475" modified="2018-11-07" version="1">MTHKRRGKRPLSKRNSSSQNKDQFMDLAQAALEEADEEEEKRGLIGEVVEALIVNTGAPLVAEVISEQLRSQDIIERAAEMHEERKRLSPSPSLTEIESLKEPISDEEKEDTVKKRDTTDQPLMITEYSWRLFRLLLLASIVGLTCHFINIHRYPFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDA1</accession>
    <name>A0A367JDA1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MVD1</name>
        <name evidence="17" type="ORF">CU097_010335</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="PJQL01001570">
        <property type="protein sequence ID" value="RCH87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDA1"/>
    <dbReference type="STRING" id="86630.A0A367JDA1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="197"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="45315" checksum="72C8C9DF450FD7AC" modified="2018-11-07" version="1">MKTVTCTAPVNIAVIKYWGKRDTELILPTNSSLSVTLSQDILHSKTTISAAKEYTQDRLWLNGKEEDITKNKRMHNCFRETRAIRKAMEDKAASEGNPIEPLSTYHLHVCSENNFPTAAGLASSASGLAALVFTLAQLFELTISTSEVSRIARQGSGSACRSLFGGFVAWEMGQKEDGSDSVAVQVAPESHWPELEALICVVSDAKKGTSSTAGMQSTIKTSTLMKERINQIVPARMEAMKKAILERDFQTFAELTMRDSNQFHAVCLDTYPPIFYMNDTSRAIIQLIHEYNASSPDGKLKAAYTYDAGPNAVIYAPKEHMPEIIQLIGHYFPSNKEPSEFFADPYNVTQGTKLGQDFIPKTHTNFNEKVIPVQPAGSVSRLLHTKVHDGPRVLSEADSLLNAEGLPKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDT6</accession>
    <name>A0A367JDT6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KES1_5</name>
        <name evidence="2" type="ORF">CU097_011299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001531">
        <property type="protein sequence ID" value="RCH88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDT6"/>
    <dbReference type="STRING" id="86630.A0A367JDT6"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="23145" checksum="0B2FD1484C4B3DAE" modified="2018-11-07" version="1">MFSYPSVTVNGIWYAAPYVELTGTSYVQSSTGLYCTIEYTSRGWISGEKNHFKCYIRRNSNPKEYIYKIEGQWSAKSTITPYNSKASQPFLDVTQLTPASMHIKEIDEQDEMESRRIWQKVSEAIRANDTQTAGIEKSKIENKQREERAARAEANHEWEPKYFRWENEEPTVSMLQRMLSSTVKSKYNPATSGNWVIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDV6</accession>
    <name>A0A367JDV6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001528">
        <property type="protein sequence ID" value="RCH88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDV6"/>
    <dbReference type="OrthoDB" id="10255641at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="25865" checksum="A974A851982DC8B2" modified="2018-11-07" version="1">MSLPPSTLTEAFRAHVQATIRLTKVVLELEWTIFTRFIVGVIVATFLSIIYLVWTLRKSRRPLVIWDRLNKPIIKLFRPRIFAFLMRNSNPYSGSIDMTITTFSRGFCTGFMRDRHYNRNTSKRKDVLTNCCKKSIHATALATFAETVGELGLLSSLSDDKDEVSLSSLELEFKKKARGLITASTDFTMPEITEEKQEVKMDVIVKDRMLDTVAIVHLVWTVNKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE85</accession>
    <name>A0A367JE85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YCK1_5</name>
        <name evidence="3" type="ORF">CU097_008608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001505">
        <property type="protein sequence ID" value="RCH88236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE85"/>
    <dbReference type="STRING" id="86630.A0A367JE85"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001123">
        <property type="entry name" value="CK1/CK1/CK1-D protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="342" mass="40050" checksum="A4C51F085794D9B4" modified="2018-11-07" version="1">MTQQIVLAHKEPDMLENSIVGIQYKVGKKVGEGSLNLLNNEKVAVKFESRDCEAPQLKDEYRAYKILAGTAGIPNAYYFGNEKTHNILVIDLLGPSLEDMFDMCERKFSIKTVAILAIQMVNLMQSVHEKGLIYRDVKPDNFLLGRPNTKHENDIYLIDFGMAKLYRRPRTNQHIPYREGKNLTGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAPTNRQKYEKIGETKRAIGVQALCEGYPDQFAKYLRYVRQLDFEEDPDYDWIKSLFFDVLKEQDQDTVMYDWMLLDDAQHWQLMTSEERKRWIRKKRHQALKRKRSAQVPENEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEI6</accession>
    <name>A0A367JEI6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CWH41_2</name>
        <name evidence="13" type="ORF">CU097_001877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01001496">
        <property type="protein sequence ID" value="RCH88279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEI6"/>
    <dbReference type="STRING" id="86630.A0A367JEI6"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH88279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="635" mass="71164" checksum="7A39E07C6173851C" modified="2018-11-07" version="1" fragment="single">SEKPLTSEKLGIALVNKEEEFNARFEATFRLKEKGFSNNKVEFAQYLLSNLLGGIGYFHGSSVVDRSHPPMLDEEDFKGEPVRPELTKPQALFTATPSRPFFPRGFYWDEGFHQLLIGEWDNDLSLDIIKHWVSLIDENGWVAREQILGEEARSKVPPEFQTQFPHYANPPTLYLAIKHFIDRLEAHQQQKLLESMVDSQLKMGTLDESSVLRNLHLDQSELASHWLKAIYSKLRQNWLWFRSTQRGHLKKFGREASSDEAYRWRGRTPNHTLTSGLDDYPRGDPSVGELHLDLHSWMAFCTGLLKEIAHKLGPEYDKDMNEYAQIQQDILANLDDLHWNEEKQMYCDQALDETQSPIHVCHKGYLSLFPMVLGLLPADSPKLGAILDMIQDKQELWSSYGLRSLSASDPFFGTGENYWRGPVWLNINYLTLQSLYKPTVALDFLSIHYLMKMRFTLFALAFTFAIAANAATLNSRSSPEVQSCVNDLTFLQNQLKTTANAVNTYLSAAGSDGATGVLNSEQALINAVDGAGASCCTIHSAVSADEAASLISVSQVLAVDVESALNAMVAKKAEFDAVESTTPAVKADLQKLQPKVNTLTGCILTAMPDGRHNDVAEYITKINSAFSNVNTAFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF22</accession>
    <name>A0A367JF22_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_009812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001448">
        <property type="protein sequence ID" value="RCH88543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF22"/>
    <dbReference type="STRING" id="86630.A0A367JF22"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="295" mass="33937" checksum="47DF0F355A62FA02" modified="2018-11-07" version="1">MQHTFCTINSTPFSYTQEIPYWNCDDLFLDTKANASYYSLTNAAATVTTDDPHQLPVLFTSFNSINYMHDDLFLDNVQPQMTPFHDDALDLFQAPLPLINTPHSNLPPECLVQKTPVDNHPEEQICSPSTLIKNNKHTPLQCTSYGESDEEYGTKRKARSTQKAIKRKRRNTSLPTLSKHQINSTRCSNCNTGNTPLWRRNPQGLPLCNACGLFYKLHGTVRPLSLKTDVIKKRNRNGPKDEKRKSKRATRTRQCNIKYQDDSSSCSELDPFEEYSPKMTKDNHYEMQLDNMNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG29</accession>
    <name>A0A367JG29_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001396">
        <property type="protein sequence ID" value="RCH88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG29"/>
    <dbReference type="STRING" id="86630.A0A367JG29"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="72560" checksum="B98563435CF66A0E" modified="2018-11-07" version="1">MVSTISYNPKLRQIHIDSGTMIYHLKTLTQEDYDTWSTALRERNYIQEQQIDQEVPSTQSGLSLSNSKRISSRSLSMYNQSDKKLKAEIEQAAETASNCQQIITQLVQTLDQLRPYLQSIPAELAHSLEQQKLAAISSVQEQEIQWRNVQNCFFKNRRSGSVSPVVGSSTPQKSTILEHDEPSLHRCSSIYSQVSGYSEQFFDAEDIELSEDEDEFIADHTSSIDDGASSEEETDSRGTGSTEFLNLQSVNNNIQRRARLPCPAVADAGSALSVIRKNVGKDLSTIAMPISMNEPLNLLQKACEELEYCELLEKASTLTDSMERLMYITTFVVSTYASSQYRTGRKPFNPMMAETYENIRPDKGFRFIAEKVSHNPLRIAAHAEAKGFRYWQSTEVKSKFWGKSMEFMTNGTFHVTLTGHDDHYTFFKPSSWMKNMIAGEKYLEHSGECKVTNQTTGEYAVIVFKEGTGGGLFGAPTKRNDVVATLYDAQGTKQRRIVGKWSESLAEEVGLDKSKLSVLWTARPPGVPDYNKYYGFTKFATELNEITEIEQGKLPITDTRLRPDQRLYEEGQVDKADQEKLRIEQQQREKRKELEAACIEWKPRWFISEGDEWVYSGQYWHARETGQWPKDIFPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH21</accession>
    <name>A0A367JH21_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001363">
        <property type="protein sequence ID" value="RCH89011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH21"/>
    <dbReference type="STRING" id="86630.A0A367JH21"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="79" mass="9359" checksum="A6401A6420CF27BC" modified="2018-11-07" version="1">MEVCHLCVEYILKILNQQNVIDYLLFADEHMVKGADRIFDAAFTFLCREAYNMDRHILAILPLNWLEKVVESDAFWVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHC7</accession>
    <name>A0A367JHC7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001309">
        <property type="protein sequence ID" value="RCH89327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHC7"/>
    <dbReference type="STRING" id="86630.A0A367JHC7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="569" mass="62171" checksum="B6B4968D86D30BCF" modified="2018-11-07" version="1">MVEESCNKQIPSQSSFSTQAIADNNSIQSNSVEQKPNDEDNNSRSKKSNVLWTFIGLQIALFLAALDGTIVATALPTIGSDFNSMSIVSWVATAYILTFDSFQPLFSKFSDIFGRKWILMFGIVVFLIGSLLCAVSTSIVMLIVFRAIAGIGAAAVFSMVFVVVADLVPLEKRASYQGIINAVFGVSSVCGPLIGGSFTDYVTWRWNFYINLPIGAVAMVMIFFFLHLPIPKEGFITKLKRIDFVGTFIVLAFSTLFLLAMNFGGQTFPWKSAAVIVPLVLTVILVAILYYVETKVAEPLMPPRLFKNRSVVAVLLTNWLLGMTFFSMLYYLPVYFQVVRGDSATWSGIRLIPMQLFLSVIATVVGFFISKSGIYKPLPPIGMALLTICVGLLSILDLDSSFSKVYGFTIIGGFALGFVIPAAIIALQASVEPKDIAVVTGLGNFSRILGGALGVAISSAILNTSLAQDLALYVPADIVSKILDSSNYVRNGCPPEYLEIVLKCYVDAIRLIWHVMIGMSGFGFCLSCLIKAHSIRKPKEQKEQNTSTAPESVMIDIESKTEKQDENRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI87</accession>
    <name>A0A367JI87_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001248">
        <property type="protein sequence ID" value="RCH89658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI87"/>
    <dbReference type="OrthoDB" id="2377933at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="35678" checksum="2A51EBAD3C5C7A86" modified="2018-11-07" version="1">MADYELPSMYTKDSRYDYPGIDDENDTTRINIASSSGLQIQESFRDAHVEDNRLAWLLLVTSFFILIWTVIPVVTDMGYITPWFPGDSLWRLFDPVITLPLSLFVMTRADVMNTGGRPHFCGPLSERSVAWLLWSIGAGIYVQGHGIHLAAAMFKHPVQNFNLAHPELVAQYPVLEEIYSNMRDLWEHVIAHYMYAGGAMVMSWVQLFVYRNQVHGPLSRGTTIVWCIGSVVYGLLIAGVAIEFPSGLIVGLIYCIVIGLVAVCMMLFNKMNLPKGGIFTAGRRMVIQFYLGSCVVAFIIIIAWIGKYGLLNRKAAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIE3</accession>
    <name>A0A367JIE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ACSL5_2</name>
        <name evidence="4" type="ORF">CU097_009026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001238">
        <property type="protein sequence ID" value="RCH89713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIE3"/>
    <dbReference type="STRING" id="86630.A0A367JIE3"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="61094" checksum="4DC2739650A6DA3B" modified="2018-11-07" version="1">MAFELDTLSYTLLASIVGAAALLSARNSKSSDIHPLLLNTQSDVSRLRHPGESAIYRSRMYPMNSPLCSTFERSIRTLADFYKEGGFKKHGNADFLEQEGGYASYETIRSKVERVYQGLRSVAKLVPQSKDESSFVGIYANNSYHTVLTEIACHMHGLVTVPILASYLSHILEKTKLRVLVTVESHLREVLIHVSDIPTLKHIVVVGNISEADKDKAVKAGIELIAFNELEQRGADESYDDVQVVPNDIASIYFSSANEKSKHGVVLTHKNLLSSISSYLSIVPPAQRFTSKDRLMVNLSIDNVLRYVLTAVISFAGGSIVFGSQSTDSNDADILSYLSMIPQHKPTIFVSNSWLLGQVRHLIESRYGKSFLYKRGYDAKKEYLEECRLVNDCKYDMLVFRNIRQTMFGGNLRLIYIDNDDNSDPTLATFLRIVLSTQVIQTFNLPETSSSITASMFFDYNALPEARGAPLPCNEIKLVDLPERALTAEDKPNPRGEIWVRGNNVFAEYYKDEQATSDVIDSDGWFTTGYLGEMLPNGTLKVLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ93</accession>
    <name>A0A367JJ93_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001200">
        <property type="protein sequence ID" value="RCH89949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ93"/>
    <dbReference type="OrthoDB" id="2280514at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9457" checksum="EBE425507A2DEA81" modified="2018-11-07" version="1">MGSHSSRREVGSPTTTNPSTTSVTASSSNSQLSQLVNYSERPFLKGSVPDSILIDITHVTGRLKLLTELSVACDGEDYPWYVVDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJB0</accession>
    <name>A0A367JJB0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001195">
        <property type="protein sequence ID" value="RCH89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJB0"/>
    <dbReference type="STRING" id="86630.A0A367JJB0"/>
    <dbReference type="OrthoDB" id="10294195at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22499" checksum="B858DA7CC9F2E52D" modified="2018-11-07" version="1">MRILVSVATSYQVSIFEACTESFSHQSQSPESESSTQQELIMVTPSSNSSPDIEYQSNVPQSLASIVCNPAFNSTRPEDMWNFSLSTVDMRKSNMMDKPKTPESYQQNDDEMKSSIRTMENIHQPEGPGDRYPNIESQQLISENMNTDELNHLFTMTDNLVQQQLDISSLKSDIPLWDVPSATTWNEWEMFIKHNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJG7</accession>
    <name>A0A367JJG7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_001064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001179">
        <property type="protein sequence ID" value="RCH90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJG7"/>
    <dbReference type="STRING" id="86630.A0A367JJG7"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="248" mass="27510" checksum="60C0E0C7A74EFBBC" modified="2018-11-07" version="1">MNTTSTAPLENVAVKLATDKTRRKRLKVISACCECRRKKTKCNGEKPCVGCIKTNVECKYANNNNNNNNSQQSIKTASKSTATTTTTSASTSTSTTTTTTPTTPIVANANNTTTNTFNTNQMNDINKLSLQSIEQRLAAIEDILQLLLQQQQQQISESRHMNSGYPSSHSGNYYGKRKHEEIDDYYSIRLPPPLNYSESSSSSSVSSTSPKLNTIQNLLNEGDNKQHYHPSRPSAFYRLTAGSDTRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJR5</accession>
    <name>A0A367JJR5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL3_2</name>
        <name evidence="5" type="ORF">CU097_010073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001169">
        <property type="protein sequence ID" value="RCH90146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJR5"/>
    <dbReference type="STRING" id="86630.A0A367JJR5"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH90146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="403" mass="46083" checksum="3A79B1B131FB44F0" modified="2018-11-07" version="1">MVNDNHPSIYLITYTNLFYYSPTAPRHGHLGFGPRKRTRSHRGRVKAYPKDDQKKPVHLTAFMGYKAGMTHIVRDLERPGSKMHKKEIVEAVTVIEAPAMVIVGVVGYVETPRGLRSLTTVWAEHLSEEAKRRFYKNWYRSKKKAFTKYAAKYAEGAKDINRELERIKKYCSVVRVIAHTQISKAKLNQRKAHIMEIQLNGGSVEQKVDWAREHFEKEVTVGSVFEQDEMIDIIATTKGHGFEGVTHRWGTKKLPRKTHRGLRKVACIGAWHPSRVMYSVARAGQRGYHRRTEINKKIYRIAKGADAKSGTTEYDLTEKKITPMGGFPHYGEVNEDFVMIKGCCAGSKKRVITLRKSLTVHTKRSALEKVTLKFIDTSSKFGHGRFQTPAEKHQFMGTLKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK92</accession>
    <name>A0A367JK92_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001134">
        <property type="protein sequence ID" value="RCH90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK92"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="22484" checksum="97982363C6F0F141" modified="2018-11-07" version="1">MKSRKDPATNCENVLLELVSLHWVGRMTVAEGKKKSSEAMLGDNEENEYENWKTVLTFWALIALRSKKYFENQGFGVHVDLDSRSTIDFECRLWGPNQAVFGCSMNHKEGNRTILFVKLCIKVNTNRQNEPKTTMKELTYFGEVISYLRYTFPDGSSRLLALAKLFDVKINKDCIWLYKASSAALRIKVVNADEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLU1</accession>
    <name>A0A367JLU1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001050">
        <property type="protein sequence ID" value="RCH90903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLU1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="125" mass="14517" checksum="D119EB40C15551D2" modified="2018-11-07" version="1">MNNNRAPFNSDEPNPWLLDMVLQQLNATPKSIIAYTAIKLLHQEQEERKLHFMKAYEEQQNVVFKECVQEMRQYLQEAYQESAHHSAAALQEIRFTMEAACLDNETTTKGLKATVTQQQSMLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMF1</accession>
    <name>A0A367JMF1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001018">
        <property type="protein sequence ID" value="RCH91113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2148641at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1322" mass="148184" checksum="BDB4C14D520D43B7" modified="2018-11-07" version="1">MTEKHIEVLRVEQSVVSKELAKFRPCDNETRSMYCREWAQYVYKKHFVWNAKTQEDVDRDHAAYVNAGKYQIKVILDESDLSEEEKDLYEKEHSTVLIKQFEELLNTISDLKTQKEKSLVQLISQACRQWMTLPTGRSGLPDLFEPVEFNSYPDNIPLVDDDQDPSQLLDPLIIERQALCLPSDCFHLLKSMTGDIIISHTTPTCNHKKPTSKTPADLEVDRTILTEHEQAAVKKALEELAIALDNIWKPLNTFLEQLEAQDKIRSKLLGADCQETIDAFFASQKYVPFVDEWTNNQLPNWKKIKKPSEEDVERLDRFVQDHFRHLGSLVDQFLSEFVTTRFRDIREWNINLWKMIHPTIKAMDERISSLELLRGKQSSTDKSLRALNVDSLKKMESTKEVDSSEKRIMAELEKRVSEYKKDIEELIKSYCESSRPTLASRMDRLNNKDFKKKIKKVESGYYVIRQFFRYEITENVFPESLFGRFMLICLKPLMQEGEVMEAMTIEKEVQRFIESHKDLLQERCILLSRFEEGVQTGRRELAGVIGKLLLKEGMRIQGETVALQRQNNLLKVFGVDPEEPSPADVKKSPISVNAAATAAKKAVEPKKKAGSTTATEESKKKKSDEESKMKVEPKKQASSAEGMVKTAAAVAASEPKKKELVKEEAKKQVAPKVANTTSQQPPVSQQAASKVPTVPESIKRAASIKPTKPADQVNPSTGTPKKAQISFDPSKDVAQARVIDDKASANPPRSDKKSVEPSVGNEWPTLESESKGQDTTCQPAKEKKENDVQGWAEIVASVTSDVKKETWNSAPAKADEIKDGGWGNASAKSSEMKDEGWGNTSAKSTSESAAEATAEPAVESVVEPVTAPKIKQEAITATDGWSTVVTEISSGWGDEPKVETKPVEDVKKSEPEWRRKDKSSNQSWRELNNNTETKAKKNEDNLGGWGRKKEWEPTGNNQRDTKEGWRSSSTSSDKEVKDGWSSLKGTSESLGGWGNPSGGFTDNWGQKSSSREATFQDNKSTPKPNWDNAQVPWETSSSAPLDSVERPSTFSNNDTSFSVTPTPSASQASISKPPGLNVTTTTNEASNLISAGNVSQSIVPPSSGLPDMKEMNKPILPFTPPGQTMFMSPLSTAAVQLQEPLPANIDDFGKDMLLLMVKNLHRENSTLISTVYSLQQDMAMMNQRYAEILALAREREAQTVQLLETRKQTELEKAKRYCISLESRIKELEEKVRGGYHDRTTAGFENQDLFAGYRDEMNSGGSNNSSNNHGFHQHRGHRKMWSKATVIRCGNCGETGHSSAECKSYCRYCGSLEHLSEACPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMS4</accession>
    <name>A0A367JMS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001003">
        <property type="protein sequence ID" value="RCH91218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMS4"/>
    <dbReference type="STRING" id="86630.A0A367JMS4"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="416" mass="46798" checksum="B2BE4099C8A38953" modified="2018-11-07" version="1">MSEQTKVQDTRGFENTEESVHLTEETHSGQQQQQQQQQAVPVNEQLPENVSTLKEAFPDIDVDIIEAILQTQNGNVESSFEVLLGMSDPNYQPTPPPMPPRPQTNTNAPYTYYEQPQATTLEEQLRLDEEFAKKLAMEDELRARQRRQQQPVRQDQERSEQDSIFNLQEELPIIKEKVKEAGNAAKRKVLDLYNQFKASRNNNSFNSNPSAGGSSIPTTNAHYKGLPSDDGDDLLTGDISALHLSDYDVYTKTNNIIKRQNSEKNNDVIHVHPPAGNMSIHTSTPDEQLRADEDFARQLAEQEELEAIRRRQTSERNEPQPPQMPARKQGGPTVVIAPKSPLELGEYDYEEIRLNAAPPAKPDEKDAHTTQATNSVPYVIGDDEDSDSDDLVDADNDTENGNTNKDDTKELAKKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNE5</accession>
    <name>A0A367JNE5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000964">
        <property type="protein sequence ID" value="RCH91480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNE5"/>
    <dbReference type="STRING" id="86630.A0A367JNE5"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="306" mass="35295" checksum="237A768F5CFA8ABF" modified="2018-11-07" version="1" fragment="single">MSPVTVSTSGIGIAHLPNQRHKIVTNKGTNFTIMVCGESGLGKTTFINTLFTTIIKEPKDQSKRWTKQLDRTVDIEITKTEIEEKKFKVKLSIIDTPGFGDYVNSHNSWVPIIEFIDDQHESYMRQEQQPNRNNRFDMRVHACLYFIRPTGHRLKPLDIEIMKRLGSRVNLIPVVAKADTLTPKDLAAFKERIRQDIEANHIKVYQCPIESEDEEVTKLNKDIMAAMPFSIIGSTQEVQTPDGRTVKGRAYIWGVAEVENEDHCDFKKLRHLLIRSHMSDLIETTETEHYENYRLHEMASRKFGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNK2</accession>
    <name>A0A367JNK2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RTNL1</name>
        <name evidence="9" type="ORF">CU097_012134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000960">
        <property type="protein sequence ID" value="RCH91507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNK2"/>
    <dbReference type="STRING" id="86630.A0A367JNK2"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="111"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="329" mass="35861" checksum="EF7BA62121A433A6" modified="2018-11-07" version="1">MADTEIPPSVNATEKVVESPVAPITSTSTSAAPASTESVLATPPPSTTSTATSAPTTAPTTTTTTTTNAPAPAAPTPTAAAAAAKSTQNHSYTSPNIKFEDNPSGYLKAKIESLIYWEYPKKSATFLASTLGLLVLTQYYSVLQIVAGIFTLATGINWLYVNLHKQSQRIISNKSSQDIVNPHNHRLQVQKTYIPRERVLRAAHLTTDVAEVVTQHVTRLVLIEDNFRSLVAFIVSFFVWTLAKYVSTKYLVGFFIISAFTLPRLYLQNKELVDAHVARQSQNARQLAEQYGSVANQKAREIGCQVKDFIQKKTGKATASVNQETKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNS9</accession>
    <name>A0A367JNS9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_000997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000946">
        <property type="protein sequence ID" value="RCH91602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNS9"/>
    <dbReference type="STRING" id="86630.A0A367JNS9"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="227" mass="26311" checksum="8BC375440602A03F" modified="2018-11-07" version="1" fragment="single">KQDLELKLEQGFIEPIEKTVLSRGLSSKQAMFAKPPKILCLHMARSALDMSTGDIYKNTCRVEFPDMLDLSPYCTNGILNTTNPHLPISSVNHTTVPVRYRLMSVIVHFGSHDSGHYISFKRRLVAEKCHCLNCRDDQTLLKHHSSDWFRISDERVEACTLEDVLLANPYMLLYELVEDDVFNLWLLPLHLYLFRFKHHALPISHLQIQNADQRFGQKRLSSYANSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPQ2</accession>
    <name>A0A367JPQ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_008184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000902">
        <property type="protein sequence ID" value="RCH91923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPQ2"/>
    <dbReference type="STRING" id="86630.A0A367JPQ2"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF23">
        <property type="entry name" value="UPF0039 PROTEIN C11D3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13420">
        <property type="entry name" value="Acetyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="198" mass="22589" checksum="B4468BE887CB26A3" modified="2018-11-07" version="1">MNKTLELYNIREATEADLPQICEIFNERISNSTCIFVYNTVSLENRLAWFNDLKSKGYPIIVAAEKESDKAVAYACFGSFRPHPAYVLSTEISLYIHQQHQRKGLGGLMLKEMLRIAKDMQFHSIIASITADNEGSIVLFSKFGFRHCGVTHQVGYKFGKFLDVVFMEYLTDAPIISQEIPSFKAFPWGAYTFNESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQE5</accession>
    <name>A0A367JQE5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000903">
        <property type="protein sequence ID" value="RCH91911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQE5"/>
    <dbReference type="STRING" id="86630.A0A367JQE5"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="24033" checksum="F95ECF78F2AE5EB9" modified="2018-11-07" version="1">MSYISNLNLLYADTPTEINDDTFQEELALWANAQFSFDTAPGSAIVDDEKAKEETQLLETFKEIAQLVQPSTSIDNKNNNNNNSNSGNGNLYYNIAPAPSQNNMPAILPRLAPAMHPLGIKPIDNAMTKKLIKTEKESKEPISAEEDKRRRNTAASARFRMKKKLREQALEKKAKELTEYVEQLENKVKDLEKEAKWLRALVVEKDPNLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQH2</accession>
    <name>A0A367JQH2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000862">
        <property type="protein sequence ID" value="RCH92202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQH2"/>
    <dbReference type="STRING" id="86630.A0A367JQH2"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11180" checksum="4A177298B58E6E67" modified="2018-11-07" version="1">MQETCSMFGPILSCDMLLDPMGRPLHEAEVEFMYPQSAQECVAKLDGEIADGRVLRAQLQYRPTPPVVPRYSSRTVGVSARLGVNNDTQDYIPYLQRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQV7</accession>
    <name>A0A367JQV7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000844">
        <property type="protein sequence ID" value="RCH92327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQV7"/>
    <dbReference type="OrthoDB" id="2236952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="33394" checksum="411FBB5F5934330B" modified="2018-11-07" version="1">MNSEKQYLDLTLSNDRDHLLQTLDSMLEFNIIVEHTTLHINQCHRLIQEIQDAYTIIYQQSIHQKQVSCRKVLTRDVQAAEKFLHSIRCAVQSLEPSKPWLSDLDVRNRKFKHLIQSYKTLIEMYMAIVLDNQRRFSLFFEEQIKQIQPAIDIEQVFQSTSPPLPVQILLQRGERTNDERIQQWMSTVQDIHKDLQVLANTCKVLSELRNELNIIFERYRRRWPLILHEGDFVYVIGDNLDLIEKVPVGLLHKKNCNYKLIVILATVVILIVFFCVEIILLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS01</accession>
    <name>A0A367JS01_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_010218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000823">
        <property type="protein sequence ID" value="RCH92471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS01"/>
    <dbReference type="STRING" id="86630.A0A367JS01"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="187"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH92471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="471" mass="54218" checksum="FB10BB0B164F5554" modified="2018-11-07" version="1">MYRNLRSTMLPHLARSRVQFRHAYTQRSATPVIRLMLIQPNAATQRSLHIPRQLLRSEIKPINNMAEEASKTVKEQTVAAAAKPKKTIWQKVKEEATHYWDGTKLLGLEIKISSSLTWKLMNGGKLTRREHRQLRRTTSDLMRLVPFAFFIVVPFMELLLPVALKLFPNMLPSTYESKSQEEKKRIKLLKVRLEMAKFLQETISETGFRGTTDGMAAQEFAEFFRKIRITGEQASTEDLLNVAKRFEDELTLDNLSRPQLVSMCRYMNIHSFGTDNFLRYQIRSRMRQLKADDKAIMAEGIESLTLPELQNACASRGIRALGTSPARLRDELAQWLDLHLNHKVPSTLLILSRAFSYTDHGMTMEEALKATFNSLPDNLVNEAELQVLEQVGASTFKQKLEVLEQQQELIEDEHEQEAKEEKARLEAEKLAEETKLAEETKMAEEAKLEEDLKETANQKEEEFLSTPNKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSB6</accession>
    <name>A0A367JSB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000778">
        <property type="protein sequence ID" value="RCH92796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSB6"/>
    <dbReference type="OrthoDB" id="10342198at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="13661" checksum="C3B4C7026D6D3AF4" modified="2018-11-07" version="1">MSQFKVHSSLNLNISGFFKEYDISNWTFSNYYDYEKTMRPSFCISDLDKISNLSYLSLEDKSRIGHAKRLRINTNGESSAIINNSGTVVSNSSNATIQNCVVGSSEISKKRKIIFTKEDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTA6</accession>
    <name>A0A367JTA6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000735">
        <property type="protein sequence ID" value="RCH93146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTA6"/>
    <dbReference type="STRING" id="86630.A0A367JTA6"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="235" mass="28370" checksum="9A1CE67CAB4A6189" modified="2018-11-07" version="1">MPDSREYDHSKKRQHSPHSRRSRSPERRRSRSPQSRRHSRDRSPSPHRRSPSRHHRGESDQDNKRYEERRRRKDDRRSFDDKRYFERKQSDEKPAGPNINVVLRGLPDNATEEDIAKRLGEMNACIEEVSLIKSRETGESRKFAFVRFTSVGHAMQFVEKHRTFHMKDFRVRVDYSHKNNGSLEKEEWRCATCGKFNDIHRRVCVECKQSNIRKHRFIFIEAFEQLINAFDWIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTI3</accession>
    <name>A0A367JTI3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000720">
        <property type="protein sequence ID" value="RCH93253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTI3"/>
    <dbReference type="STRING" id="86630.A0A367JTI3"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="50281" checksum="2454FF44C0830230" modified="2018-11-07" version="1">MKHLSIELVELIAKQCRASNKDLASLCLVNRHFYSAVIRLLYKNVIIHGPRQYLAFKSTCTRLKQMVYRLDFSGYTTRGARWTESKAKSVVTAEDLAVILNECRQLKELFVGEELMHVFVSPLAIQSVFFEQQLRTLDFTGFSDQTFTKAMADYFMEKKQVTYNHHYDDASSHWVIPKELENISFYMCMALSQDRFFVPFFDKLKSGGHQLKKLDLAYTQINSQLFRHLPSPRTLTHLNLQGCHSLSCCSELIDYLIQCKRLVQLNINRHIASGFCKRCIYRLLTSIDTLEIVDIGGHVEFDDELIQQLPPNRNIKYLSVANCRQIDIKALLNKFPQLYYLNVERVIHMNQLYNFLKSNNNNLRIIEVSSHPSLLNQIESWHLVKHGRRTYYSQSAVDPRYCYSKKIVMSKDPILSPMNRYWCYSYNIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTK0</accession>
    <name>A0A367JTK0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000714">
        <property type="protein sequence ID" value="RCH93302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTK0"/>
    <dbReference type="STRING" id="86630.A0A367JTK0"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="41283" checksum="820D3B7F0BBC3BC0" modified="2018-11-07" version="1">MTITTLFSPVKLGRYQLKHRVVMAPTGRFRCTIEGVPTELVAEYYGQRASPGGLLITEATAIHESAGPYPYVACIFTKEQIEGYKLATEAVHKKGGLFFVQLWHGGRAAASVFMPNGEQIVSASDIPVAGKNRFLEDADYEVPRPLTKSEIKDVIQLYKQAALNAIEAGFDGVELHGANGYLIDQFINSNSNNRTDEYGGSIENRARFALEVVDAVAEAIGEDRTAIRFSPGGSFNGVRDDTVVETWSYLTSQLQKNHPNLAYIHFIERRYDIDADVDSISGDSLEPFRKIWKGTFIASGGFSTAREKAFEYAQQHDVLISFGRAFIANPDLPERLRNNWPLNPYHRPTFYTHDAVGYTDYPFYNAKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU59</accession>
    <name>A0A367JU59_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine nucleotide exchange factor DBS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MCF2L</name>
        <name evidence="3" type="ORF">CU097_009796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000694">
        <property type="protein sequence ID" value="RCH93467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU59"/>
    <dbReference type="STRING" id="86630.A0A367JU59"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="180"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="342" mass="39530" checksum="FB28FB5A351675FC" modified="2018-11-07" version="1">MPFENLVSKRKKLLRFSLREKINRKVSSFSTSNLSISSRNSRQSQEEPTKKNDRRNSPRLRPISQFFFSRDEEDSLEECPEFSRSSSSTSTYSLQTPVTPSRASSRKRMSAIITSSDGSREDVRAAISIWKERVSELSACECGQSDCLSRFLLELNLAKDRPEMQKQRFSKSPSTKDTSMKKFILNELLETERSYNQLLHLIQSKYMQPMIQEASRSKYSLVKSSDIPLLFSHLPELLQLSNKLLAQFNEKPNQIGQVFKDVDSEFVVFLKYAIHYKTNMKSIRKACKNSLFIRIDQEILASRDTNRLGMSDYLIAPIQRIPRYCLLIKGTLLLLSNHDINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUE4</accession>
    <name>A0A367JUE4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000683">
        <property type="protein sequence ID" value="RCH93547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUE4"/>
    <dbReference type="STRING" id="86630.A0A367JUE4"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF139">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834231" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44019" checksum="6F75E40CC51958A8" modified="2018-11-07" version="1" fragment="single">MFILIALFAGALLAAPSDGFKSSDINTLISFGDSYTTRSINLSNLTYQCRDCTSAGSPNWVTCLTEAEEWISWDFAMGGAPLNDMLVHKDPSIIDIAGQIQDIYPSVFVSPTYTKSPRTSRSTLNNIWVGINNIGLTYGWRNTDQVDAAIMQQYKSLIKELIAYGETRFMLMNVPTIERSPIWTNTTVMSKSIKKHVKAFNNRLSKVTKDMKKEYSNSTFIVYDTWSFFTQVLDRPDKFDIKYTQKYCPDWKANTKEISLSTNATLEHSFDTNLPPLSERELQQLTDQEKNKDVSSYDQTDVDVYDFATLRDELGAHEDVLLEDDDHLGDQLIEEGDINNDITFADAPVDKDFDFSGNTQKFSANFKETGFTEEEAFFAKRRTKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUY9</accession>
    <name>A0A367JUY9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HCR1_2</name>
        <name evidence="7" type="ORF">CU097_008774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000658">
        <property type="protein sequence ID" value="RCH93760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUY9"/>
    <dbReference type="STRING" id="86630.A0A367JUY9"/>
    <dbReference type="OrthoDB" id="2265577at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="209"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="579" mass="66762" checksum="009E922F91A61070" modified="2018-11-07" version="1">MYFQANQKDMSESRFSVNSNLMNYSIPTETRVDHKREIKQGDSDTRTRQLEAQIEQLTLQNVKLQRTNRLLKVDTDNLIEQRTSPLEKMIEELTIANIKLQRTTRLLQQELDEKTEQLNRLKENQILQMKSVGPEYEFLVQNINLLQRQLAGHPICEGTCCFTMKPVDHSTMVMTLPSTDNDEDGEEELEAQHICRPVIHSDISQGSYATELEHRIIRLEQIIEELDQEKEQILRQQNYKDNDLETLKKELKIKDEIVSQLEQDFMCLEDQLEHLQKQLQEKGTDGVNRPSSSLIPQDLKRQSQLLMESKRRSLAIKDTHLLEQILKGDLAVGGEEGPNYTHKEEFEQVNKVASTKPKMAWDDEDTEDINNNVKEDWDESEEEEEPKKEQKVETKTVTPPVKKNLTLKQKIAEKEALLKEQKKKKAALANRFLDGETEEEKFERVHGIKGGEGEETAEAPKKTPSKPVESLKPRTRADFEEFRQLLTDLILQHSNVSGYATFLEQLARDLADPMKDMDIRKAASSLTALANDKQRQQREALKNNKKTKGKGQSAKTATPAPAAPTREYSTTYDDFDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV91</accession>
    <name>A0A367JV91_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000679">
        <property type="protein sequence ID" value="RCH93581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV91"/>
    <dbReference type="STRING" id="86630.A0A367JV91"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81419">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="68" mass="7471" checksum="0F271C4E3B728165" modified="2018-11-07" version="1">MSLVNRPNNVLAHQRYFQAPSNTPLFLRGPRDKLFVFTTFAVLSVGVAGALYGAVNMARVSKLYTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVB8</accession>
    <name>A0A367JVB8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_008657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000639">
        <property type="protein sequence ID" value="RCH93924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVB8"/>
    <dbReference type="STRING" id="86630.A0A367JVB8"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="652" mass="75063" checksum="B7781A8B2B100189" modified="2018-11-07" version="1">MSTDLKKSRIIKPRCSLYEAIKLRSLKNDRSFGRKFRVPSKHILSLFTSANNHIYQFVFPDSEFCTPFYCDFANTAYDGHLVAIGDEEGRVSLLRTDKDNSINNSQFHHSFYCHKHAISDVKWSADDSLLLTASHDRLVRLWDTETRSTLADFAGHDDIIKSVNWHPTNQHLIITGSKDGSFRIWDTRFNQKPGTDSADSPDIPIYSPIKTTMNAHDINQGSRSTKKSGLKPLVIRSVTSAIFINNHEEKVITSGSVDGTIKLWDVRAGRSSQVLESTEFKNEAGKRHGITDLKVDSSGTRLFSSCMDNSIYMHYLTDLTKPAIKYTDEEFKLGSFDIRISISPDDQFIMAGSYDKDIFVWEINGNQKKAHKFEGHTRKQKMADNRRSLLIYGAAATLVAVLGTSLVYYVIEDDKRAKRRRAAKQAERATLRLLDQIQSQQQAIESSISSVEPIIELDCDDKAFKQKEYTLAHSNELLLRLMEQLDAVRPLTLIVGQDLEPTEFERQLVDKLKNKKRSVIDSINELFRRLDICNERVKKEAAKREEVAKEKARLEREEKERLAREEEERKKAEEEERKRIEEEKAQQAREEQERVAKEEALRRMREEEEQAAQEAISKETDNHDDDKSFEEIQSNGQVEVSYIELNEVEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX06</accession>
    <name>A0A367JX06_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal growth factor receptor substrate 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000575">
        <property type="protein sequence ID" value="RCH94466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX06"/>
    <dbReference type="STRING" id="86630.A0A367JX06"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="124"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="251"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH94466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="82270" checksum="FC093A45631571C2" modified="2018-11-07" version="1">MNENSLALLTPQEKQVYLNYFKKVDSDSKGIVLQEEAMNFLKKSNIPQNILNQFWEAADNDKKGFLTDTEFCIILKLIACAQHGVMTGDPILATSAPLPQFNGDDNSSRQPPRHTTTDVITPEERTKYISLFQSLGPVDGILNGEVAKNVFIRSGLPPAKLQAIWDLANTRKSGTLNQTEFIIAMHYIERTMKESAPLPPTLPAGIYASAIGRAISSPLVRQNTLQVNKAPIQSPVFKGSTLGNVEIAPEEYARYKTFFDQLSNGTGFVSGPDAVVFFRHSKLPESDLARIWDVADTNSTGQLTEREFAMAMHMINRRIAGGEIPSSLPTLRTGHVEHQQPQQTGKQPAVDLLGISSDFDETFSPATFQPTSKPQPQHHQQITELSRTQSILQSNLSSETTRSQQAHSQLEAETRAIEELQKQIQQQKDELEKMKHLADEAEKQLEAEKKKKEKLKEELQMYRHETKHFKSRAENAQEELKQVKREIDELEKEKSVISSPRLPNSMSSSSVSRPEDVFALSSTGGLFAKVHDDRSSVSASSPKSTHSMPATSTQKSFDPFAGFKASQSTSQSTTGTPVTLNKLKEESELKRSTSSTVDISEIESKFPDLSTMEQSFAAVSPQAPTNPATASQSIPPPAPKEEETIATTKNESALEDKPKKESKYNFDLSAFEPPSTTSNSNLFGGMSVKDELSSIFGSPTTSSSTPAPTASTSAALDDIFGSAPSTTAKDNNKQPAQSSFEDIFFNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX43</accession>
    <name>A0A367JX43_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="20">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CU097_011509</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="20"/>
    <dbReference type="EMBL" id="PJQL01000601">
        <property type="protein sequence ID" value="RCH94231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX43"/>
    <dbReference type="STRING" id="86630.A0A367JX43"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1027"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1091"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="22">
        <location>
            <begin position="176"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="24">
        <location>
            <begin position="878"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="17">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="826"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="832"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="856"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="856"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RCH94231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1199" mass="136247" checksum="24D644D10FE5993B" modified="2018-11-07" version="1">MSTTNALPTAKPALLPSGSKDLSDKGLTRKKEKANTTGNDTSTSPYARANLRLPKKRNWLDRIVQRFKGPQPLSGGAEFRTIHINNQLLNEEQEFLHNGVTTGKYNLLTFLPKFLYEEFSKYANIFFLFISCIQQIPGVSPTSRWTTLVPLVIVLLITAVKEIIEDWGVHRSDAELNSKKCKVLQGTQFIEQKWRNIKVGDIVRVESGQHFPADLILISSSEPDGLCYIETSNLDGEVNLKIKQALPQTAHILNPVDVSQLQGVIRSEQPNNRLYNYDGTLSISSLGSQRRDLPLDPTQLLLRGAQLRNTSWIYGIVIFTGHETKLMLNSSRKPSKVSNVTRITNRNIMYLFWILLGMSLAGAIGGVLFSMYKGQQATYLPLHSWSHGQEFGYDILTYLILFSSFIPISLMVTMEIVKFALAYLIENDIDLYYEKANTPATARSSSLVEELGQVKFIFSDKTGTLTCNEMQFRQASIGGLFYADQVDAERRARDDGQEQDPNAQYTFDQLKQHLNTHSTANVINEFLTLLAVCHTVIPEREEGTHQIVYQASSPDEGALVKGAASLGYTFHTRRPNSATCTILDQELEYQLLHICEFNSTRKRMSAIIRGPDNRIKLYCKGADTVILERLAKDNPFVEPTLLHLEDCASEGLRTLCIAMREISEEEYAHWSQIQQAASTTLVNRAEELDKAAELIERELFLLGATAIEDRLQDGVPDTIHTLQEAGIHVWVLTGDRQETAINIGYSCKLLNEDMSLIVCNEDNHWSTKAYLEKKLKDINEVMIKGEELEPLALVIDGRALTFALDKSIEKTFFDLAVLCKAVICCRVSPLQKALVVKCVKKYDRSILLAIGDGANDVSMIQAAHVGVGISGVEGLQAARSADFSISQFRFLRKLLLVHGAWAYQRMSKMIFYYFYKNVTLYLTQFWYAFYNGFSGSTLYESWTMSCFNVFFTFLPPIVIGVFDQIVSTRMLDRYPQMYTLGQRNVFFNQKKFWGWIANATYHSLVLFFLGVAAFRSEGVFRNGLLSGQWWVGASVFTSVLGCILWKGALIIDYWTKYTAIAMIGSMAIWFLYLIIVVYIAPAISVNALPEYYGIVPMLWGNTSFWLFLIIVPFICNLRDFIWKYGRRVVRPTSYHHVQEIQKYNLPDYRPRMDRFRQAVNKVRRIQRLKRNRGYAFSQNETDQTKIIRAYDTTLQKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXM6</accession>
    <name>A0A367JXM6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000543">
        <property type="protein sequence ID" value="RCH94752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXM6"/>
    <dbReference type="STRING" id="86630.A0A367JXM6"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="13641" checksum="DA8BFD1E3B6BA8FF" modified="2018-11-07" version="1">MSVTPVNADNAPAALGPYSHAVKVNNLVYTSGQIALDPATGDIVKGGIKEQTEQVLKNLETVLKASGSSLDKVVKTTVFLKDMNDFVAMNEVYGYFFSDHKPARSAVQVARLPKDVDVEIECVALTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXZ6</accession>
    <name>A0A367JXZ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_003090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000540">
        <property type="protein sequence ID" value="RCH94777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXZ6"/>
    <dbReference type="STRING" id="86630.A0A367JXZ6"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH94777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="421" mass="47203" checksum="E814BB11708D42F2" modified="2018-11-07" version="1">MNGITIDFELNAENQIKLAKTFKSFQWKYLTVYTLVMGTDWLQGPYLYKLYQSYGLGLTSISMLFLTGFISSAIAGTAIGSLADVYGRKRVCIIFCFTMIASLLLRLINAYSLLFVSHVLSGLSTALLYCVFEAWYVSEHASRGYPAEWRARTFALCTFLNSCAAIAAGVFANILVDVWGFKSPYVASIVLQAIVCSMIVSSWAENYGTDQMERKSLQRSLREGIYVMFQSRNIMVLAIAQTLFECSMYIFVLLYTPAIESVAEDSNISLGYLFSTMMFAVMAGSLVFQLCERLNRYGTRLLSITSKERLLIIALGLASCSFMMMTYYGQYSAFLMAAAYHLFEFTTGLYYPSIASLKAECIPEETRAVIMTLIRIPMNLGVGIIIWQIEDISTAMMFSLCSLFNELVNIMMNLPGKETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY80</accession>
    <name>A0A367JY80_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PEP1_2</name>
        <name evidence="15" type="ORF">CU097_011790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000533">
        <property type="protein sequence ID" value="RCH94849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY80"/>
    <dbReference type="STRING" id="86630.A0A367JY80"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016743419" description="rhizopuspepsin" evidence="13">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="84"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH94849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="394" mass="41406" checksum="D0AA2EB76A8B692A" modified="2018-11-07" version="1">MKFTLISSCIALAFVALAVEAAPGGKKINVPLTKNENYKPSAKKSLQKAIAKYTKHKFSTQSSGISPESGGTVPVTDNGNDVEYYGIVKVGTPGVELRLDFDTGSSDLWFASTLCSDCGSSQTRYNPSKSSTYQKDGRPWSIQYGDGSSSSGILGIDTVELGGLTIKKQTIELAKTESDTFASGEIDGLLGLAFDSITTVRGVKTPVDNLISQGLISSPIFGVFLGKASNGGGGEYIFGGYDSSKIKGELTTVPVDNSQGFWGITVDGSSVGGQPVTDSFSAILDTGTTLLVFPNDIASQIAEAYNAEDNGDGTYSIDCDTSYLPPLTFSIGGAEFEVPSDSIIFEQDGRNCIAGFSYGDLGGLSILGDVFLKNNYVIFNQEVPEVKIAPSINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYH1</accession>
    <name>A0A367JYH1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="6">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CU097_008447</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000509">
        <property type="protein sequence ID" value="RCH95042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JYH1"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0853">WD repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="27">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="28">
        <location>
            <begin position="258"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="26">
        <location>
            <begin position="585"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="1112"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="1460"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="1600"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="1691"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="1730"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="519"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="RCH95042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2266" mass="253730" checksum="57E31162E1B32982" modified="2018-11-07" version="1">MTTTINEKRRQAEEGGGPTRIEAQHKKGKLTARERLGLLLDRGSFREYDTFVEHECTDFDMSQHKIPGDGVVTGHGTIHGRKVFVYSQDFTVLGGSLSRTNANKILKVMDQAMLVGAPVIGLQDSGGARIQEGVNSLAGYADIFQKNVLASGVIPQISVVMGPCAGGAVYSPALTDFTFMVRDSSYMFVTGPDVVKAVLNEQVSQEELGGARTHTEKSGVAHNAFDNDAEALQGVRDLLTYLPQSNREPAPTVECDDPVDREDEAIDRIIPSDSAIAYDMKEIVARVTDAHSFYEISADYASNILVGFARLSGQPVGVIANQPLVSSGALDIDASLKAARFIRFCDAFNIPLVTFVDVPGFMPGTSQEHGGIIKHGAKLLYAYCEATVPKLTVITRKAYGGAYIVMSSKHLRGDYNVAWPSAEIAVMGAGGAVEIIFRNHPDKATMKKEYKERFATPLFAAKKGYLDDIVEPRHTRARLIEQLNLLKLKNLVNPAKKHGSFFDEDVILSDKELMDDTYHQVTEDEEEQEEQEEEEEYIFEEEEEYEEIEEEDDDPDWGSSHKKKSTPSITQAKKQIKKEVDCDIKCSNCETTNTPLWRRNPEGEVLCNACGLFLKLHGVVRPLSLKTDVIKKRNRSGNMKRRKWLITNGWSPLVPVFYEHKIQHDQFLNLTMEKLDDVLNHVHISHSEKQRLLSAIKQVKADQAQHQHLHRQSLPRIIIPTSNNHTKITTSPNNQHFDISQYIPKRTSSTESNVSKILEAFQPSILHMKTKSPTSPRINPSDPEILSKLLGKRVPLQHALTQDRRIQVTLDADTFIKLWIKESSDALTIKHAVLQKLSIDADPSYFYFYHENGVQSTIPLTDEELVRVCQSSDDSRTNRVLVVPVEGYELMCQQRSTYHDPHYVRYVLAPAGYHFANPPSIPSSELWATPPSKHLLNTQPSSWPAEQQLNVEGISLYDPPTPRNDDLDFTAVKSFTSSSATPTEPPSPIGSQKSDGDAFAEDDVLGERPSVEKLYRNIDQYLPGHDLDKEITVENNAIPPSISRRLHGHRPSVRVVAKEAHRRWRQETRNVGNTVLRRKSTKMWGSKVERVKPGEEGCIVASDKPVPTRMQWMRGELIGRGSFGRVYHALNVATGEWIAVKQVDVAVTQADKRNQDLKEAADALYHEISLLKDLDHINIVQYMGYDFNPDEGLIFIFLEYVPGGSIASLLKQYSVFEEPLISFFTRQILQGLEYLHERGILHRDIKAGNVLIDQNGICKITDFGLSKNQNESAYDSASNNSTMKGTVFWMAPEALTNNYSAKVDIWSLGCTVLEMLTGTHPWMHLTSLAALYAIGNHKSPEIPSNISSEAKDFLEQCFRINPEDRPTAKQLLEHPFVQPNDSFNFKPSLYGKEGLGVLGNLSQLSNSRPIHPARCIHTISQEDNNSVLSLVSSRRYLFSGSQSSKIHVWCLQTFRLVTILRGHTGSVLGLTLSADEQYLFSCSGDGTVRVWNTETLTCAYLIQSCHDVGDIFSVVYSDKHNMLFFGSQNTSIQWYDFADPQTHGHKIDIPSVPPSPRRRKGKPINFFELSGHLGEEEERIQELLDKNVIKCVIREKNVYSNAHDGYVYCLLHAKDVPNMEGEVLISGSGDGNVKIWSINQGVIQHMRTLKGNSDKGILSLALSEDGYLFCGVQGGDIQIWDLETYQMIRSVIAHTDDVLAIAVRRGGFISASADGSIRLWDEVFQLKEVLIEHHGIVLSLTEREDCLISGSSDQSIKFWDISSNAHAPADIMRRYSSGTLQGTPSTDMMLYVLEKWVAIRTVSGMPRYMEECRRGARFLKNVLQQLGAVSRMIPGASGRNPLVYGRFSGKGNDQKRVPTVLIYGHYDVIAVEHEKNMWGSDPFELTGKNGYLYGRGTSDNKGPMLACIFAVNELLKEGQLDVNVVFLIEGEEESGSIGLYEAVEQNKDLFKDVDMILLSNSYWLGEDVPCITYGLRGVVHATVSICNQRADLHSGVEGGAVSEPLVDLIHVLGKLVDTDKKVLVPDFYKDVRPVTETEERLYDPIIEWMKTSKTAQSSTRTHHSTIALPSPVKESEADKETQCKMKIADEELDAETQKKQLMARWRYPTLTIHKIDVSINNPTIIPRTAKASVSMRVVPDQSISEICSQFTEYVHEVFASCKSDNKISVNIESVAEYWLGDLNNKYFRAVETAVEKEWKVKPLYIREGGSIPAVRWLEKFCNAPAVHIPFGQSSDQAHLHNERIRLLNLIAGKRIIKSLLTALPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ22</accession>
    <name>A0A367JZ22_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000495">
        <property type="protein sequence ID" value="RCH95170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ22"/>
    <dbReference type="STRING" id="86630.A0A367JZ22"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000947">
        <property type="entry name" value="serine/threonine-protein kinase OSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="542" mass="61069" checksum="E41E85C822C27EBF" modified="2018-11-07" version="1">MLTSDPVKPILVNNVNEVKPRLNSLKVSTNHLSLDTSSCSPISPVWSMNDFELKNPIGYGSSATVYSAIYKPHNKKVAIKVINLDKFERNQIDELRRETTLMALSKHPNVLPVFGSFVHGPKLYIVTPYMSVGSCLDIIKIKPEGLDETTIATILKQVLEGLAYLHKNGHIHRDVKAGNILMDQNGTVLLADFGVASSLMETGVRKTFVGTPCWMAPEVMEQAAYDYKADIWSFGITAIELATGRAPFAKLPPLKVLMLTLSSDPPTLCRETSANKYSKIFKDMVDLCMNKDPYKRPMAEKLLQHPFFKQAKKPDWLVKNLIKDIPSIDQRPIKSVEPKVEANSKAADEWDFSDINNNRPKRHISFGHAVVKSRGHALAKRALSDDFRKPRLGKHQHQASAPSVFPIFQDEQQQMTRNCSIHDKSSLVTFSEEQAITRKTLYRTQSQEGFKKNGDTIVQPKFVEAKKVGRFELRQSIPVHHQLNELLKQNDAQKQLLNELYTYVMNKEQQQQPSNHELSSIIVSNIIISQSSTHYSSDIGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZF7</accession>
    <name>A0A367JZF7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000478">
        <property type="protein sequence ID" value="RCH95326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZF7"/>
    <dbReference type="OrthoDB" id="2272375at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="17902" checksum="05DE34E171734C0E" modified="2018-11-07" version="1">MSSIIKPSSFNRSSPVIFPSASPTPKLYMTPSKKIPEVTPWQEMAFDAYHSPNIFSYEDSILKMKERYQLSTAISPLSIIDPMDDLDLQLSEEDLLPLSSSAQNEIIIGSPFIPSPVQDPITERLRQSTDTTSNKAQMQSSKLAFSREFTQKVKKSTIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZJ7</accession>
    <name>A0A367JZJ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000473">
        <property type="protein sequence ID" value="RCH95384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZJ7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="109" mass="12294" checksum="9C06D170C1799C80" modified="2018-11-07" version="1">MNGFCLEKLLIKAFFELCRLYVDKCGKVKKESNALHGHMVFLDVKKVPLDEDVGAIEHQYGCIGTRTVSIDFTMKVTRQYQFAKNVLEKLVLDNPSTVAVPSIEIGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0E8</accession>
    <name>A0A367K0E8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Up in starvation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">USV1_1</name>
        <name evidence="10" type="ORF">CU097_003291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000448">
        <property type="protein sequence ID" value="RCH95617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0E8"/>
    <dbReference type="STRING" id="86630.A0A367K0E8"/>
    <dbReference type="OrthoDB" id="2256232at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="276" mass="31490" checksum="898D820B72376F1B" modified="2018-11-07" version="1">METSIQPSEKVIVTNDSTKKPKRKDKDDKEEKPFRCVGFGDCTMAFTRQEHLNRHKRRHTGEKPFPCIVEGCTLRFSRNDNMRQHAERCPCRNPDSEGTKRKRSAKGQPQPTGRKRKLAPRSNPGRASKKGKSYHEDDEYEEGSQEEQLKAPLVLQNGSSSSTDTEMSPSPGPIEPSPYRNRVRTAPRILFCSYGRNDQEIDFQAMVQNFSLFAPRNAKPTRRLSLQELASSIDRLEEISSSSSSEEDSNAVGITEDEYETLIAIRELHRTPYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0M0</accession>
    <name>A0A367K0M0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000435">
        <property type="protein sequence ID" value="RCH95753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0M0"/>
    <dbReference type="OrthoDB" id="2219748at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47589" checksum="F78D9481782E3587" modified="2018-11-07" version="1">MPGFRGIRMVSFDKDQQKVVVRSPQAVEAAACVVWPEPAISILVDIMAIFYRHITNEPNQREEYYQKAFAALAFHLMQLEKEKVIPPDFLGNMTKEKMQMKWQEIEHKYSNVASSLTPGGPTGQQIWPYFDKVTFIFQTSRIVPPETTRHSVSEGALEESNTTNPQNSITGHIPPTSASMPSSPAPVTACSPENGTISRSTAASETDQAQLSPHQESPKELSEQEFRKEMLCLMRRRVELLEEQKAREDKKHEERREIMDRLVNVLEKLAEKLNILSNAREALYFNKELSILDIGYGSGVWPMDHHGNNAIHRFADSVHVVSNSRGQNARIGKELKRMVGEVGGAEIVQSECKQSDDNGTAKRFAWSWHEVAKDMMPAIKSVLGLKDEQDEEKFLTDLWHSLRTDDYDYIVYAVLSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0Z0</accession>
    <name>A0A367K0Z0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DEIH-box ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BRR2_1</name>
        <name evidence="13" type="ORF">CU097_000140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000453">
        <property type="protein sequence ID" value="RCH95561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0Z0"/>
    <dbReference type="STRING" id="86630.A0A367K0Z0"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000388">
        <property type="term" value="P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF5">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="199"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH95561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="971" mass="111739" checksum="5B77039F0680BC30" modified="2018-11-07" version="1" fragment="single">IIRRLERKEFPWERYFDLNPQELGELLGQPKLGRTLHKYVHQFPKLDLQAHVQPVTRSLLKVELTISPDFQWDEKVHGIAEAFWIMVEDVDGEHILHHEYFILKQRYAEDEHFVSFTVPLYEPLPPNYYITIVADRWLHCETKLPISFRHLILPEKYPPHTELHDLQPLPVTALRNPDYEKLYAGWISHFNPIQTQVFNALYTTNDNVLIGAPTGSGKTVCAEFALLHLWNQAADSRAVYIAPFQDLVDQRVAEWTEKFKKIGQGKEVVALTGETSADLKLLERADIICCTPTQWDIISRRWKQRKNVQNVDLFIADEIHMIGSDLGPTYEVIVSRMRYIASQTQRPIRIIALSTSLANARDLGEWIGATSHSVFNFHPSVRPVPLEIHIQSYNIPHFASLMIAMAKPAYIAITQHADNKPAIIFVPSRKQCKLTAVDLITYCIADDKAHQFLRCKPEEITSILERVQDKSLVETLQHGIGFYHEALSKQDKKIVEQLYESGAIQVLIASRDTCWAVPLHSHMVILMGTQYFEGKEHRYADYPITDVLQMLGRGCRPLDDETGKCVLMCQANKKEYYKKFLYEGLPVESHLDQQLHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMARNPNYYGLQGTSHRHLSDHLSELVENTLTELEETKCIAIEDDMDISPLNLGMIAAYYNINYTTVDMFSVSLKETTKLRGLLEIVSSATEFDNIPIRHHEESILQRIYDRVPIKLATPKFNTPRIKTNILLQAHFSRIQLPPDLQSDQTLILDRIIPLLQACVDVISSNGWLPPALSTMELSQMSVQAIWDRDSPLKQIPYFTNDIIKRCEDKGVESVFDIMELEDDVRNDCLRLDQQKMREVARFVNRYPNIEVGFDVADKDAVTAGSIVNVKVQLEREADEDEEIGPVIAPFYPKKKDEGWWIIVGDPETKTLLAIKRVTLHHKLTVKLDFVAPKAVDVIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1S8</accession>
    <name>A0A367K1S8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000401">
        <property type="protein sequence ID" value="RCH96099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1S8"/>
    <dbReference type="STRING" id="86630.A0A367K1S8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="326" mass="37024" checksum="E7DB3C47E9DBDB69" modified="2018-11-07" version="1">MGNHFTKCRIKLTFKNYSEQQQKVFDRAAMAETEQSSMDDSTNNITIPTTKREFHNVQTSTYWLPKDDSEQMRLSAQHYAVKEVFKTNVLPSVTEVLDFNRGIDILDVGCGPGAWIIDMMNDYPNCRYQGCDMVDVINRKTMPEQLRFCTGNVVEELPYADNTFDFVHMRLFVLALRSNEWPKAIKEILRVTKPGGIVQVLEPNLDLPKETDNLFYKASKALHIICQQRGQIPSVGRELERMLREAGNTKILESVYIPTDTTTGTIAAKKLAWSWSEGARGAMSVLGPAMGVTDEVEQQKFVKDLHKCMLTKCGFYNFNAVAAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3M5</accession>
    <name>A0A367K3M5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 UFM1-protein ligase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000340">
        <property type="protein sequence ID" value="RCH96746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3M5"/>
    <dbReference type="STRING" id="86630.A0A367K3M5"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="1">
        <location>
            <begin position="358"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="425" mass="49436" checksum="DF57E075A7708E52" modified="2018-11-07" version="1">MCSIQGFDTAENLYIFNNAVDLIKDNYDPNSYYVLHSCIIKTHIKDSAKDALQSMTDYCDVNDVLPNTLTLEDVNKVIDLCVQELASTRKIIILEGGYVTTPEYIQSLIEECQHYLYSLAQRQKQKDHKGQARNNKHRLQEPAIIKALEAINCPYHLAEKILPLVRKPLNDRFDEMMQTPYTAQIKMDGDSWVVKQKSREYQTLVSMRSSIYFNYKAICLFKDETGRRSLEKYLLKNQCTEFLYHFVLYIILDQSYSRAEVEQSTSLCISTEDITKQSITDIKQQRSVIAYFIRENDHKYDKTGVLEIEGLLKKKKLASFIDMFLLQDQQRLFQGSPSIDKEHATRQTNKMVYEQLYKQLEQTIISEETAPQILHLVSLLLFLKYHQLPLYVSGKFVPIILNQLEHKLTEEEQALVGRAHANKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Z9</accession>
    <name>A0A367K3Z9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000355">
        <property type="protein sequence ID" value="RCH96591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Z9"/>
    <dbReference type="OrthoDB" id="10404140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="96" mass="10795" checksum="7910D149A5E7D938" modified="2018-11-07" version="1">MKKRERPPNEILALNKNLKADEDNDDADSQDTIETSSTSISSGNLYVPNEGSFLDSLDVDVPIPYVLICHELYSLNQLDMNDISFLSLSLSFEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K591</accession>
    <name>A0A367K591_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain and WD repeat-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BRWD1</name>
        <name evidence="6" type="ORF">CU097_011191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000286">
        <property type="protein sequence ID" value="RCH97330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K591"/>
    <dbReference type="STRING" id="86630.A0A367K591"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057452">
        <property type="entry name" value="BRWD/PHIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF17">
        <property type="entry name" value="BRWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25437">
        <property type="entry name" value="BRWD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BRWD/PHIP N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="546"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="893" mass="101236" checksum="D0AE56474CBADD3D" modified="2018-11-07" version="1">MGCLYYLITKFLAAGPCKNAARVLENELAQHKELLPHSINYEGKKVPMTIDRLSKEHPNISDNYLLDLLERLLDHFKETGDPKKARVSALRHGDRSLMTMLSAFIPKQDEKNHCNYLNMTKEQLRGLSIHRLLIARELGVKVFKKNQVPTSLSTFYRELVTISGHRNPVYCVAFDKTNRRLFTGSDDFLVKVWCVRTGYLIHTIRGHQNIITDIAINQENTLIATASSDGCVRVWTMDEYKPIMCLRPNTTTIKPFTTVKFSPSPRNDTRYLMATNEDGLARLWRWDRDTLEFFDVDSPIAFSCKFRARDRLRCSSFNYTGTQFAVAGDDGFVYVFSTIPVEVVYAGTTPSHHDSSANQHQSQVGRGRRRVPSVLFPDKSGHIQSQTVVPIGILEGHMGSVTDLAYSHNGQRILSGCQDGTARIWHFNKTTEEWESIVLDLKQPMDAPVVQFEAPSHKQSNISHKRYTDTEEFGSCIPFDDNDESISSMDQDVDVNNTAEQPSSAINQVKVSMIAWSSDDKWCIVASNQGEIRVYYAYDGRPACMLKGHRGEVYALDNHPLDPSTLLSAGYDGNVILWDLARMKMITRHHHAGRTFTDSKFSKDGMKYAITDEEGHCTLYGIGGLEKDYEQVRSWERGQYFMSDYQALRYFTDGSFVDEATQQMPYALPPSSIIDLQGVAYPNQKKLGYGRNIPTVSETFELEDMKRSACYAMEEEEMRKVKAIKLPSLDRATIARKRRDFVKSSDEEEAELAANTPFQFPPPLQPFLLPDDSEDEDYREDGPDNAAYASSGESSEEAGSDDFVARDDQAESDADQEEEGPVTRSRAGQRRPSPSPIRGPSSRGTVSSTRRTNAPRRRGRPRLNRDNMRGTGRRGRPSRKRNRSDDEEEEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5G8</accession>
    <name>A0A367K5G8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000280">
        <property type="protein sequence ID" value="RCH97405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5G8"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="48349" checksum="C1EC52B02688DA28" modified="2018-11-07" version="1">MTWIKTLKQQMKKPANWMKKNKRTMVYLLKWIITLISVGLISFFMLCRLEVNAHVYLRNWLSPERPVAIEPLSHCFDNLSPDSPYHQGNKNFTVNFVPGLPVWEANTCYDFAALFHSRRYPYAGSQLYHTYWSSNLTKDFDEKPLATLRSFAATQNTNHTMILWIPKEDEQRLTNSKGWAALSKDTNRISYRIVQPMDLTKGTAIEPYVDVWRVLVSENNDGTHRDDLLRMLVLYQFGGVWFDLDTMFIRDLSPLFEHEWIAQGSCKTGMFGNPFTGALFHFNQKSPYVCEILEGAADLFKARERQANGESDIPKRHLIKGPEIFGSKLYYRIYRRVLHHRIKPWSILPWCFTDPSQCRRSNSMPSLFSNTDFDEKQVERIFAYHWRDRWSSVPGSIYNYLSSIHKKRITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K633</accession>
    <name>A0A367K633_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sorting nexin mvp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MVP1_6</name>
        <name evidence="14" type="ORF">CU097_008854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000257">
        <property type="protein sequence ID" value="RCH97683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K633"/>
    <dbReference type="STRING" id="86630.A0A367K633"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000042">
        <property type="entry name" value="Sorting nexin mvp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="226"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH97683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="601" mass="69346" checksum="13328F4CFBE66E81" modified="2018-11-07" version="1">MLHEDDDPLSTSLFDTTSTTASTFLGNSMNTSMFVSQYEEDPWGSSYTNTPDMNRSFTTPNFATSPPVHTTADAADSSPLTRKRTEYNATNVLSGVRLPEIYDSLFSQHQRSGRVSYTTLSSILTKGKISANQIEKIMQIVAPNGASHVTQPEFNTALALLACAQHKLDINLDSLHKNKNYLPELSIILQQEPPKPVNNTYPGMKKETVQQKHDKPLLDTKHWFEDIEEITVTVAPEREGFIFKHVNYIVTNEKRSSIVLRRYSDFWWLWEVLLKRYPFRALPNLPPKKLGGRDAAFLEKRRKGLSRFINAVIRHPVLRQDDILSKFLTEPSELAAWRKQNPPNIDEEFKRKPPSIDQINALIPDNLDEQLQKTKKRVSAAIHHYINLCLIMERMIRRMHGQAADYSRYSIALNSLAEAELRYHAGECRNCQQVVRGYEMVAKHMQSESSILESQIGNATDGVLENLKRFRDLLVSYRDLEERRSRLSVNQTDAITKRLSANRAKLHQNSGVPGLEAEVERLKESIEADENELVMQQHRLIYIRYCMWSEMIYIHKQQAFISTLYQDYVKNTIHFSSLRSNNWQELEEPTFEMPTDVHLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7N1</accession>
    <name>A0A367K7N1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Staphylococcal nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000217">
        <property type="protein sequence ID" value="RCH98180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7N1"/>
    <dbReference type="STRING" id="86630.A0A367K7N1"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000018">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000002">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="168"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="318"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="496"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="697"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="98669" checksum="07989D7A70C0E94A" modified="2018-11-07" version="1">MVNKAVVKNVLSGDTVILRGKPRPNGPPAERLLALSNVQAPRLGSTARSDEPFGFESREFLRKLLVGKEVSFVPEYTTTTQREYGSIYLANGENVQELGVKAGWLKVREGGKTTSEDKQDVLDRLEQLQDEAQAAKVGMWNDAEKGIRDISFTFEKDPHAFLSKYKGKPLNAIIEQVRDGSTFRVLLLLPDNTQQIITLSLSGIKAPTCKRDNAEDGAVSEPFGEEAKYFVESRLLQRGVKVVLEGLSQGQTFVGSIQHPAGNIAELLLSQGLAKCVDWSITLATSGPTPLRNAEKLAKEKKLRLWRNFVAKAPTETNEFDATVIRIISGDMILVKTKNGGIEKKIQFASIKQPPRGAGSTAPTSKSKDVKEVGYQFEAREYLRKKLIGKQVHVAIDYHKPAQEGFEAKDCATVIQGSQNVAEQLVLRGLATVIRHRKDDDNRARHYDQLLLAEKKAEEQQKGVHSPKELPVTRIVDASESAAKARQFFTFLKRAGKLSAVVEYVSNGSRLALWIPKENCRVSFVLSGVRAPRVGRTPTDKSEPFGQEALDYVSQKCLQHDVEVEIENVDKVGSFVGSLFIQSENLAVSLLERGLAMIHEYSADESHYVNQLYGAERQAKNEKRGLWAEGVSEEVEQTNTNTSTGPNREYIDVVVSEILSGSHFYVQKITDEIQKLEALMKELDEYYSSRPADPAFKPRVGDLVCAKFTEDDGWYRAKVRRISHEGIEVHYIDYGNSETLSSVRVRALADKFKTLKPQAHEAVLSFVKSPERDQDYGIEAYERFRQLTANKQLVANVDAREGNTLCLTLYDFRKSTSAEVSVNLDMVQDGQAYVTPKVRYTHGNETIIKTLQEAQEQAIRRRLGMFEYGDITGDDDIRDTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7Z9</accession>
    <name>A0A367K7Z9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP synthase complex assembly protein atp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ATP12</name>
        <name evidence="6" type="ORF">CU097_009693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000207">
        <property type="protein sequence ID" value="RCH98305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7Z9"/>
    <dbReference type="STRING" id="86630.A0A367K7Z9"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="31901" checksum="2FC76B9561B08100" modified="2018-11-07" version="1">MKSALRPFNQITRRYIHRTPFACQSESEAAAQRAERTLKRFWKRAGIKEDQESVTVVLDHRNLRTPGKHIVQFPKQQRQLALLTAAEWDSQTQNLKAHSLPLTSIVARAFDTFDPTRTLDTTVRTGVIDKLMQYLDTDAICYHEEFPEALTQLQDTYWKPIIEWAQTTFDVKIDTTTTIFAVTQPKETREKLRNIVEQMDSLELAAFEKAVMSSKSFLIGLALVKNGITVETAARAAHVEMTAQMERWGEVEDSHDVEREYIRQTLGSVAVAIMHKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8J3</accession>
    <name>A0A367K8J3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000188">
        <property type="protein sequence ID" value="RCH98552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8J3"/>
    <dbReference type="STRING" id="86630.A0A367K8J3"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10001">
        <property type="entry name" value="HDAC_classII_APAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF17">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="220"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="387" mass="43297" checksum="FC47403F850C6D1F" modified="2018-11-07" version="1">MQVVYCEDELLHNPPMELTRGEWKPYVESPKRLEAIKQVIDQYPSDFEVIQANDYSLKPILEVHPSDYIQFLTDIYHQWTQAGYPPDACVADTFASITRTVNRDVVKQTANSSLSGKLGFYTSDLSVMFMKDTWKAVYASAQVVLTAAHQLLLTSAPAIYALCRPPGHHASDAVAAGYCYINNVAVATRFIQNYTLEDMNKIKRIYNGNNDVNRTENIDKSNEKKKVLIVDIDYHHGNGTQEIFYDDPTVFYISLHGHPDYPYFTGSAQETGSGQGLGYTMNIPLLSTSTTDTIYLDSLNHALEDERVVRFNADIVIVSLGLDTWHEDPIAGMKGLQDPNTYKAIGALIKSSNGTKNRPVLFVQEGGYTIDKLGQLAVNVLKGFMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAE3</accession>
    <name>A0A367KAE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Forkhead box protein J3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FOXJ3_3</name>
        <name evidence="8" type="ORF">CU097_015458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000139">
        <property type="protein sequence ID" value="RCH99213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAE3"/>
    <dbReference type="STRING" id="86630.A0A367KAE3"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="50744" checksum="C0BE83B420690CDD" modified="2018-11-07" version="1">MIPRSIPSPTFKPHKSDISAGTPWMQSSPCSENTKPTKTSPAVSDMKVEKNTEGKPPYSYATLIKYAIERSPGNKLTLSQIYQWVIDHYPYYASAGSGWKNSIRHNLSLNKSFVRVPRPVNEPGKGSYWTVDQYAQLNDTKIRSNHRGKRPAPELSRTFSDPWPTSRRSLSTDAGPIRNYGYCLHPYAYDRSYPYPSYHRYPQEASWLSARHNSTVTYSLPPSAMTNLKNYENFYDVRSNYTSNTLFYPHRQSCPDLTNITYPETDAVPNFCLREPTDVSPSCDKVLYNSNQSDILKNTPFDYNQSNDTKLVDQSNFYHQQGANLPSPIASPINMSSPIDNNSNNYISDCLTSSSSPLVITNHNSPIEDALKSPYYNPLNYLDMVPQSQEASSESLGSSCSSSPQPSSGLGKSFTESPKFLQFMSDKDTIKSQQEHNMISTDGRFEFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAN3</accession>
    <name>A0A367KAN3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000134">
        <property type="protein sequence ID" value="RCH99274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAN3"/>
    <dbReference type="OrthoDB" id="2384637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="12551" checksum="54C334416C36D357" modified="2018-11-07" version="1">MADLNWCTFCDKAVSPFSESLYCSEQCLRADALRNHPLLGYTYPEFIDFPRKSSTTSSSTTTISLSSTSTYSSPSTSPALSASSSTQFSSPPKFDLSLSFKKKSHNAYFSSFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBB0</accession>
    <name>A0A367KBB0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000126">
        <property type="protein sequence ID" value="RCH99399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBB0"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016885701" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="16367" checksum="28676A9D263CA479" modified="2018-11-07" version="1">MKFSRILLALVPIFALTTAAPVVIADNPSSPFYVTEPSQETTFVKGEVIRLSWSNGKPGTLSINVLEGDDPNSMQPTQWAASLQSVSGDSVYSFPATAFFEETKTYCFQLVFQDQDTTYESFSARFKVANPSTEVKRDSTKIGPPYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBW9</accession>
    <name>A0A367KBW9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000103">
        <property type="protein sequence ID" value="RCH99743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBW9"/>
    <dbReference type="STRING" id="86630.A0A367KBW9"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25794" checksum="C64371F8A4A4B844" modified="2018-11-07" version="1">MSCHSTNSSDGDSSSNPTEWTCLEKLLLSQAVYKYGENSWLEVASVLKQNALVQHRHSDFFNHKNCYFQYYLLTEGLQTEKDNQTPAVVRLARQLYMQRIQEIKNALVHHEQQLGQLVSEIDLIRKGELDDRLKVEYNLVSTNMSQSDPDLDSKHGKTDTPELEIIKTTVEFERDIVLMLTNALMYNKEGTETYLLALEMLEDVKDQIELFKFANSFFKRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCK4</accession>
    <name>A0A367KCK4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000089">
        <property type="protein sequence ID" value="RCH99954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCK4"/>
    <dbReference type="STRING" id="86630.A0A367KCK4"/>
    <dbReference type="OrthoDB" id="408511at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF25">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN DDB_G0277895-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="156" mass="17622" checksum="92A507CF62952C2D" modified="2018-11-07" version="1">MSAEYGTVNTTQDEEAPLISREVSENETFIQKVKRVLHLHGHRVLISWIIVIAITAVLTLSFHFALKERHDTTTPVGDDEKALLEEMCVSDRSWFVALMLSIFLGPFGIDRFYLGYIFLGIIKLITAGLGGIWWTVDIILIALNVVPDHPYGCHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD54</accession>
    <name>A0A367KD54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000079">
        <property type="protein sequence ID" value="RCI00118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD54"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9194" checksum="040B47DCC2BE3EBE" modified="2018-11-07" version="1">MDKTITLEIPLPNERLATIAARVIEVDKELKADQVKRTIAAEGNILKVRFDCYTTKMLRVSVNSFLEYLTMVTRTMEAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDS4</accession>
    <name>A0A367KDS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YPT1_2</name>
        <name evidence="11" type="ORF">CU097_014685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000064">
        <property type="protein sequence ID" value="RCI00374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDS4"/>
    <dbReference type="STRING" id="86630.A0A367KDS4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI00374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="22622" checksum="4EDA21E173F68099" modified="2018-11-07" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDEDSFHHVKQWLQEIDRYAAEGVNKLLVGNKSDLTDKKAVSTEQANEFAESIKIPLLETSAKDATNVEQAFLTMAKQIKDRMGSTMQQTQAKSTVKVGQGASLEPKQSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE78</accession>
    <name>A0A367KE78_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000056">
        <property type="protein sequence ID" value="RCI00516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE78"/>
    <dbReference type="STRING" id="86630.A0A367KE78"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="273" mass="31150" checksum="3ED0743E8C55688F" modified="2018-11-07" version="1">MSTRLERLANKEANEKHAKILTELLQKTHNKHCADCRRKDPRWASWNLGIFICIRCSGIHRSLGTHISKVKSVDLDTWAPDQIESMVHWGNQRANAYWEANLGDRRPEDQLMDKWIRAKYEQKKWVESKQVPDPSVIKVNDTNVDTEMKQTERVEKRNSMRLDYDHYNKTNYTQDKRASLNIGSNVSSSSTAKTDPISATLIPSPKPATFNNSSNKSDKPFKVDMAAFQEQLSKLALGRPSTGLIPRAPEGSEKAWANIIMSSRESTTTSKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEA5</accession>
    <name>A0A367KEA5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000076">
        <property type="protein sequence ID" value="RCI00172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEA5"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="631" mass="71294" checksum="B89F174D063E257A" modified="2018-11-07" version="1">MLYSESTVTYKKDVLRVILDEPRLFLEESLGSTLIRGEVIVNFPKDTPIQGPIELVFEGTQRFHTWPEIMRGRSLGNPIETKLQVIELSLLPPNSKGIMPAGIQRFPFEFPIPASLPASTFIKDRIEIFYQVIATIRRSTRLDQPSHTNPLSWIEKVRNTGLKKKYVHSASLRIVRPIQSFINEGASEQDTISVPSPLSIPSDEPESHNDSHQTSSSDTSPSNDNRASTGSQMGLAWNRRDLSEYQGFDEQYNQFTFSLAGRTISNFNQPAEKLQSVHGIRYKMSVDRTALVLGTSIGVELMIEPTVRKVKLKSILLKISENRRYTMKIPADHSWDSRLPETRKYDEGVKMILKWAYNFEAEEEELGMKNVANVDTCVGCKFVHQRSEDNTKVAYFDPPSPGDPSTKLFLTSGASSKSSSTKPCPIKEVENYNTNSSGQKKLVNLKEIDQPIKPGEYFGGRFVMPMPDCDNILHPSMTYDSIKINHWLQLSVTLECDNETFNIDLDSPMQMLDCRLVAADDENQTILPPPPTYQEQEANSFQQNFYTASTFWEQREPITSVSGWGDCQPCPCEIRKMQKGKNKQDKSKRTSGSIPFMSSSSQAKPSKDDTDADSYSSRFLPEWGPPPCYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF43</accession>
    <name>A0A367KF43_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COG2_1</name>
        <name evidence="13" type="ORF">CU097_010057</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000040">
        <property type="protein sequence ID" value="RCI00787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF43"/>
    <dbReference type="STRING" id="86630.A0A367KF43"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="12">
        <location>
            <begin position="405"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="550" mass="64292" checksum="1B1F3235B0E4AFDD" modified="2018-11-07" version="1">MSRHRKKQSIFSFSDDDDNEQQQQITVKPLPNHAVERSELVADDFDPDMFLSSKRHLGLERMKVELNAHLKQLKSELVELINRDYQDFVNLSINLSGVDRDIEELAQPLNTIEHQVKEAQDHFQKVIDSLQEQLQYRAQLRNKKATLKLLLNIHESISKVEYLLDINTEIAKDKYKLENQLAGDDSLGKQIERAAIEYNQMQHLVGRGKDLAFIRENSWRITRIKDTLEQKLSKALHTALLQVRAGELTRSTKQSLVQCLRTYALIDQTEVAEKIIKEQFVRWHLEKIIHSKILQNNKTSKEDPLDDMYKKILLFASKDLQPILDITQKTLKGSNYEVLVNSLWAEITEEISKKCRAIFAPGQMTVFHKNYTTTISFISSFEGLCQSRRSMVYLRHHPTYIDFMKKWQLPVYFQLKLREIVVRVEDVLNDNTQSMNKGEDNRLEGTRVVMSTIQECWSDQVYLYGLSHRFWKLTLQLIKRYTLWVTDMLQITNSNVKTMLCSDVQYVIESMQTDTGKLILLKLPINVQEQPLIKESLQEALDQLKLVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFD9</accession>
    <name>A0A367KFD9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000035">
        <property type="protein sequence ID" value="RCI00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFD9"/>
    <dbReference type="STRING" id="86630.A0A367KFD9"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39587" checksum="F52811CA3E7EE508" modified="2018-11-07" version="1" fragment="single">EYQVGDEIFNNYGPKSNEELLIGYGFCFEYNEYDHVTLKPNFSQDLNYQVKLNILQNCGISSGNVDPYTFYIHRNNVPPMFLKMMRVLVMNNMETAYYRSCHDPKFLDMVGYRNELSMLSMTLTLLKTRLIALKSVNLDTSDYIPAWRKFALMYRAGQEDVYNVTIAKIEEMKSRIISCMNQDIKENRMAPNVPFLSIVNPDYDYTSLTIDSSPFVSLDMVVITLDSLLRKNDPFSTAITEIFEDFDEEADVIFMLSLINEKFNENSKWKELFKRISSSDTTVSQDEQELREMYDSMIPEFAEAYPHVFSLDKFSFESFVWADNVLNNYSIDNPLAIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFY8</accession>
    <name>A0A367KFY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WDHD1/CFT4 helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000028">
        <property type="protein sequence ID" value="RCI01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFY8"/>
    <dbReference type="STRING" id="86630.A0A367KFY8"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="1">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="10160" checksum="B8F1E6D067C5BB4A" modified="2018-11-07" version="1" fragment="single">MKYYHIHELDEAEGTGKQDECQDTFDSADIEMDKDILRLINTACKPVRHSRALGLLNSLRLSESVDKAIRIASFHHLSSLANSMMRIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGB5</accession>
    <name>A0A367KGB5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000018">
        <property type="protein sequence ID" value="RCI01264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGB5"/>
    <dbReference type="STRING" id="86630.A0A367KGB5"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="33"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="294"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="359"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="415" mass="44761" checksum="BF22E688578409E7" modified="2018-11-07" version="1">MAKHKRSSALLSSKRSHKRTPVAIPRATEKGNIFICGSNDASQLGMNDDVEELNKLTLVESLKDKEFTDVVCGGMHSIVIDSEGTLYSWGCNDEGALGRQGEESTPAPVPCGGATIVKVACGDNVSMGLTEDGQIYSWGTYRGNEGAFGFSIGISKRTAPMLHPVLGTETVIDIAAGANHSLALTNRGRVYAWGYGAQGQLARRISPRFEKNWLRHDSIGLKKVKLIGAGSYHSLAVTTDNKLYAWGLNNYKQCCDDESQFIFKPMLVPLPENFGEIVSVQGGEHHTLILTKNGEVYAYGRGDAYQLGLQQDVLDSLKVTSSDSAFRFYVPTPTRISGLEKIVSISAGSEYGLACSEDGRSYCWGYNSGNAIGNGSDRDEPTPRLQVFEGVGDKQVLRLSAGGQHSLCLAKESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGB6</accession>
    <name>A0A367KGB6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YCK2_2</name>
        <name evidence="7" type="ORF">CU097_015745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000022">
        <property type="protein sequence ID" value="RCI01170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGB6"/>
    <dbReference type="STRING" id="86630.A0A367KGB6"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="60"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="560" mass="64341" checksum="326554A171E9B23C" modified="2018-11-07" version="1">MSNSPYRQQFIQRKNTHSQPINRKPSITDNIALGVECASFDSIRTDLSIGSKDVIVAEQWLVLGRIGEGSFGEVFEAEDIDTGRKYAIKREPLKMRHPQIKHESIIYDVLAGGPGIPQCHWHGQHDEFDCIVIDLLGPNLNQLKEVTTKLPVDVVIDFGCQMVTIIEHIHKRGLVYRDVKPDNFLFPAQCILPEPEMIESTDDQGTSLIKYRYPTCDEIFQKWNMPRPKLHIVDFGLTTWYKDPVTNKIYPESKKNYKNKTGTARYASLNVHRGKSHARRDDIESIGYLILDLVFGTLPWAGIQARNSRAGWDKMKQIKQDTFMSDLCAGLPQGFLEFIEYAQNIKFAEEPNYELLRQFLQGSLPGGKYSNIVRSPFGGHTEQKWLMNVEKDPALTGQGRPANPNRYQEFVRASPQQPRRRKQSYGYHENNDEGLFHMDDLTNAINDLKSSSRKRQSITHRRTSKDAGKLAETGPSSFQKLVAKTRKKQRPVGWNSHRHENEPWNPVTDWEATSDKNNKKESSWGEDNIKATWGNKEDTWDSDNREENTWAASVQKPWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJZ7</accession>
    <name>A0A367IJZ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005520">
        <property type="protein sequence ID" value="RCH77953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJZ7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="62" mass="7107" checksum="468E52876BFFE05B" modified="2018-11-07" version="1" fragment="single">NEKKYLQSLENRTFQEAVFSNLTTTNFLEQVNKKKALSSNSAASSAEEPTEEINKRIEEIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILU0</accession>
    <name>A0A367ILU0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004996">
        <property type="protein sequence ID" value="RCH78667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILU0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="56" mass="6076" checksum="C9679BF0DA1B8763" modified="2018-11-07" version="1" fragment="single">MGNLPSKGGEWIESTAALPKRMRSNSKQFNGDPSLIPSKLLPSNSKRYSKTSVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INY6</accession>
    <name>A0A367INY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CIT1_1</name>
        <name evidence="2" type="ORF">CU097_000620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004541">
        <property type="protein sequence ID" value="RCH79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INY6"/>
    <dbReference type="STRING" id="86630.A0A367INY6"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="31234" checksum="F236F9E28E02D04F" modified="2018-11-07" version="1" fragment="single">MSAIRAFTSVKAAARQTSFRFTPAVAIGATRAYSSKVKSLKERLAELIPEKQAEVKAFKKEYGSKVLGEVTVDQVYGGMRGIKGLVWEGSVLDAEEGIRFRGMTIPDCQKALPAAKEGGEPLPESLFWLLVTGEIPTEEQVKALSAEWAARSSLPAFVEEIIDRCPKTLHPMSQFSLAINALQHESQFAKAYSSGIHKSQYWDPTFEDTMDLIAKLPNVAGRIYRNIYKDGKLPSIEADKDYSYNFSKLLGYESNEDFVELMRLYLTIHSDHEGGNVSAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQQ7</accession>
    <name>A0A367IQQ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VPS5_2</name>
        <name evidence="3" type="ORF">CU097_004182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004161">
        <property type="protein sequence ID" value="RCH79995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQQ7"/>
    <dbReference type="STRING" id="86630.A0A367IQQ7"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="118" mass="14112" checksum="E09CF80835AC54C3" modified="2018-11-07" version="1" fragment="single">AYQTYQQADSELQRKLALFEKVKAQQKNKPDKLAASQQEINEMKQRVEELEQEFDDISKLIKSELDRFDKEKVEDFRDSVQQFLCSMIEHQKQIVALWETYFEQTEGLEDEEEEAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUP7</accession>
    <name>A0A367IUP7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="13">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_000194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="13"/>
    <dbReference type="EMBL" id="PJQL01003450">
        <property type="protein sequence ID" value="RCH81404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUP7"/>
    <dbReference type="STRING" id="86630.A0A367IUP7"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="38"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="10">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH81404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="526" mass="59976" checksum="CBAEEC9B09CCCD95" modified="2018-11-07" version="1" fragment="single">MQSRRKIYVNMKIPEEEYKEQHYPTQSKQQPAEQPQAKWDYVRWKELNVGDYVKIENDQDIPADIVILSTSETDNICYVETQNLDGETNLKQRQGLPGTAGIRTEQDCEQAKFYIESEPPHVNIYQYNGVLRWQIDVNDTETIRSGVSHEKADAVTYNNILLRGCVLRNTKWAIGIVVYTGSETKIMLNTGRTPSKRSKMAKATNPHVIANFVIVAIICIVSSIMDSVQFNSSGSSRYFDYNIEGSNATYSGFVTFWVTLILYQNIVPISLYISVEIVKSVAAYFIFADLDMYHEETDTPCIPKTWNISDDLGQIEYIFSDKTGTLTQNVMEYRKCTINGVSYGLGTTEATLGALKRQQSHHHQEKETEAGLNMQEFIQDDLIGNDQLEQYKQEMFAKQAQLYENKYIGPNPTFVDPKLFDDLAQDTKQAMAIAHFYQTLALCHTVIAERPDKSNPNYIEYKAQSPDEAALVATARDLGFVFLGRESNKLLVCIKGEKKEFELLNVLEFNSTRKRMSVIIKPKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWT3</accession>
    <name>A0A367IWT3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003134">
        <property type="protein sequence ID" value="RCH82137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWT3"/>
    <dbReference type="OrthoDB" id="2288255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="15381" checksum="2ACD49D5A1DCF463" modified="2018-11-07" version="1" fragment="single">EFTTKYDQHTVKYLDDGLVKVPKSLRDMLALLVQKNQRKTNSLYTVGFIVMGLCLELVVLDVPVGSHIARITRTARFEFPSAVENMAVDFLPLLQLVFKGKQAMVMANKIANDRKRKEVELLGSNSTPSFLPSFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXP1</accession>
    <name>A0A367IXP1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hsp90 co-chaperone Cdc37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDC37</name>
        <name evidence="8" type="ORF">CU097_001072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003005">
        <property type="protein sequence ID" value="RCH82465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXP1"/>
    <dbReference type="STRING" id="86630.A0A367IXP1"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH82465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="395" mass="45061" checksum="41987D7D91BBFC88" modified="2018-11-07" version="1" fragment="single">MPLDYSKWDNLELSDDSDIEVHPNVDKRSMIKWKREAIHRERAERKAKIEYLQKFIPQQKNVLQKVKDLKNLLNQDDGVKKVMEKLESYQSEAEAFDLPKPPAGQPQLNIKDIFAAMKTQIATGLAQTSSEQVKQTLLERFCQTESTVQKTVDNASQELEKLEKEARKKLTSENMFTSEKSSKTILNKPKPLSSNKKTTEKTTVIETLNPNTAMKDLTLDDKMTSLTNKEDDDDADEEDVDLTPDAAVFSKLKTFEESHKYLLKHPELLTEKVSDSLLGEAFTAQLKGEEEYARNCVVQSVVLQHCGQLGRNGVEIFFKKINAQDGLAHKMFFEYVDSLYNRIKKRCTEMIAEQSSQNQVETIQLQPMGDGSQLTIRVPQPEDEQAYTAFTGMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY35</accession>
    <name>A0A367IY35_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002989">
        <property type="protein sequence ID" value="RCH82509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY35"/>
    <dbReference type="STRING" id="86630.A0A367IY35"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14416" checksum="B2574FDDBD641F2E" modified="2018-11-07" version="1">MDKLKEKLADLRSQAESANALCEEYEAKIKQLEQEHTSKDHELLSLQIRIKNLEEQLDKTENSLQTTSTDYNKADLRAEEAERKVQKLEQELLDKEQGYEELTEKYNSAKNELDELARQMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYC7</accession>
    <name>A0A367IYC7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002929">
        <property type="protein sequence ID" value="RCH82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYC7"/>
    <dbReference type="STRING" id="86630.A0A367IYC7"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="195" mass="22477" checksum="FC939C2E253D5A2C" modified="2018-11-07" version="1" fragment="single">QSMKRFHVYDIAATSLFVATKVEECTRRMKDIVTACAQKAQKNDKLSLEEDSKDFVRWKETLLHYEVILLETLCFDLTVQQAHTSLCQIEAQLQISSSAIRKAWMLLYQCLGSPLCVLYKPNLVAAAALLLASHFTTSEKLNENWYESLQDVDASEMHELASEMLEYYMEHYLVKSSHHPSSQTSSPYPHHSYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ90</accession>
    <name>A0A367IZ90_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002813">
        <property type="protein sequence ID" value="RCH82996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ90"/>
    <dbReference type="OrthoDB" id="2281255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="12887" checksum="041CBBD1E81557CE" modified="2018-11-07" version="1">MVLEEKITETSRLKCKTIIQEASFEVVYTIAEGKTRPVAVGKQIVEHDPFTSQRYLDTPLSSLTLSSNDFHEVGSTDFVMLAKSSSVNIRLAILDYAGLTTNPEDLLKFIKYTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZV4</accession>
    <name>A0A367IZV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002771">
        <property type="protein sequence ID" value="RCH83109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZV4"/>
    <dbReference type="STRING" id="86630.A0A367IZV4"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="220" mass="25339" checksum="C026CA949A6C6C1F" modified="2018-11-07" version="1">MERSITPPLEDSTVAHEFTNYAKKSKRHGHDKDVVDDNDVRQVAGCVPLDMKNKRVLLISSRKKKNAWVLPKGGWEQDETQQHAAQRETWEEAGIKGIIAKQLGIFEERTKKNKLKAHHWIFEMHIDEVVKKFPERKKRERRWFTLEEALIATRKHPYIQEALLKSSLNSSSTLPAAIQNSPPSPCESINDSSADEKQTKEIIPEIEHKPLVSSEWSVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J033</accession>
    <name>A0A367J033_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA wybutosine-synthesizing protein 3</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_007066</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002707">
        <property type="protein sequence ID" value="RCH83305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J033"/>
    <dbReference type="STRING" id="86630.A0A367J033"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1960.10:FF:000003">
        <property type="entry name" value="tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="12">
        <location>
            <begin position="12"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH83305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="277" mass="32390" checksum="5D90ED76A003BFF5" modified="2018-11-07" version="1">MTTQHNTDFLSRKEQVIASLVEHLDPERRDKSPKGFIDAPILDLMHVINKHPDYYTTSSCSGRVAIYCPALENDKVATKGGIWLYVSHDPIPVPEKEKDSWILQLLFGNRNVVFDYERPADLVHKQLIYFKFEPLILHIEASSYESAMHLLNIANQAGYQNSGITVSRRHMLAIRSTLKIDTPIAYIENDTVYCLVDIAYLMLLVNMSNEKFQQNIERMSIFEEKMRRELENNQSQVKEETKEERRERKRREGLQKKNQVVKEKVEQQDLEDMSDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0S9</accession>
    <name>A0A367J0S9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ca(2+)-dependent cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCA1_3</name>
        <name evidence="6" type="ORF">CU097_005579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002702">
        <property type="protein sequence ID" value="RCH83321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0S9"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="124"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="422" mass="47445" checksum="CD40D46D7A523F32" modified="2018-11-07" version="1">MDRYGYPEPEEVTTSYENHYSSHTYSYTSSENRHSSSSHRISSDDSNDPTFTEQDYAHPNPNYPQPPESKHNPGPEPVPYGGMVSHQDDNNDDDKEDGKFYLHVDPTVDQDELSDFELSNCQGKKRALLIGINYVGTKNELNGCINDVQNIKNFLTSLYGFQEEDMVILTDNQENPKFKPTRANILAAMQWLVHDAEPNDSFFFHYSGHGGRVEDAHADEDDGFDETIYPLDFEQFEGTSGQIRDDDMHNIMVRPLPKGCRLTAIFDSCHSGTVLDLPYVYSTRGEIKQTNLFKHAGMGLLSAGVLYAKGDKDGALSSIMSLGKQLLEARMISSEARKRNTTLADVIMFSGCKDDQTSADAQEAGRATGAMSYALTTTLRQNPNQSYHQLLNNLRQILRDKYSQRPQMSSSHPIDVNLEFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J100</accession>
    <name>A0A367J100_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002604">
        <property type="protein sequence ID" value="RCH83618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J100"/>
    <dbReference type="STRING" id="86630.A0A367J100"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45222" checksum="43C1AB075543C34B" modified="2018-11-07" version="1">MDKTPKVSVAKRLWNLLTKRVTESKYTIAYCTLLTLSTITCIILEAIIVNADLEIYNDLQRVDPNITTYPSTSIHLASTDTDNVALGLRRLKNENVFFILVSLFQLVLGLDAVLRQSVIQLIAHTTNQFLSTVFASIQVLETSEKNQIVNQNILDAIANATGILTRIRLYFLIALRNGIGLVVVMALFSFIFVYLSYQLFKQFGWNTYKRIGADIQQQERFRLAQIFFMFLKLDAFFQLVLCIFYTVVMSQEQYFALWSIDRKKFVGYIIHIVLTALLIPALLVARYGVIAENRTVMVAFQVTQIIVIMDFILVLVDSAGTWIFWILAVCVAIALCVVTIVISFLVAKNFDKGLKPYMQRLFDSNEENDKQDKGNLLRNEEWLIDDEDDYTPSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J255</accession>
    <name>A0A367J255_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC1_3</name>
        <name evidence="7" type="ORF">CU097_005510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01002489">
        <property type="protein sequence ID" value="RCH84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J255"/>
    <dbReference type="STRING" id="86630.A0A367J255"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="275" mass="31462" checksum="9B30E313D9C73A3F" modified="2018-11-07" version="1">MLVTPLIVTVVILPLLLLLLRKFNGFYYRSIMTVASLIIMATYGMVAALVFPVFGYTQYINFTVARGHYYITKFFCGIKVVPEGLEHLEEKSPVIFVCNHQSSMDIMMFGAFYPKNTSIVAKKEIKYYPFLGWYMRLSNAIFLDRKNRENAIKEARKAAEDIRRKGVNVWVFPEGTRGHESEVTLLPFKKGPFYMAVQANVPIVPVVIANYSHLYNAKEKRFLSGVVRAKILPPISTDGIKQESADIEKLATECRRQMLEVLKEITPSETMKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J374</accession>
    <name>A0A367J374_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PTPMT1</name>
        <name evidence="2" type="ORF">CU097_001765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002375">
        <property type="protein sequence ID" value="RCH84404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J374"/>
    <dbReference type="STRING" id="86630.A0A367J374"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="113" mass="13221" checksum="FA974DCE4C5C5872" modified="2018-11-07" version="1">MIKQVRLETPDFCIPSLETMEKGIQQIHEIIRNDEQSSIYLHCKAGRGRSAAIALCYLLATYQLDPFEAQKVLNKKRPQADKDLYVSEEIRLFYKNLLSKLESNQFIRKPFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J485</accession>
    <name>A0A367J485_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002277">
        <property type="protein sequence ID" value="RCH84750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J485"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="191" mass="21664" checksum="8E17EA49A5ACEB1F" modified="2018-11-07" version="1">MTTRNTCKASKTERQTKKRHSADFRKTIQHQNRKTVIHLNRLTNHNIQQLAKKWILSFLRFQSTESYQALGAMEEDGENGILEEVSEEDGEFEELEEGGENGTAIALRQAADLPPDDFTESNLLSTASGRRPALTQNEAILANDMVVSMAPARNIQRVQPALQICRRCKRQKTIQISKQANSVDGRQPIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4A8</accession>
    <name>A0A367J4A8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RSM25</name>
        <name evidence="9" type="ORF">CU097_005548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002273">
        <property type="protein sequence ID" value="RCH84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4A8"/>
    <dbReference type="STRING" id="86630.A0A367J4A8"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="26013" checksum="AD58FB9C101E552E" modified="2018-11-07" version="1">MAYRAAPIKIAKHVSSLLKGRLLKEPPVWLPVVQSIPPGPSVIRSQNEEINVSGQTDIEKNLFSTHKTVNRQRYSQKHLRTPPPRPRAIVYPEDRLRKQFYKDHPFELARPKVLVENELGINRTDYSKLMLDGMHPSQIDGEAVIKYQLHLMTHENMTERQAYAKATAEFYEIRAQQEEEERKAKEKMNNALNNLQSKRKWTERGIYLEERALREGQIADAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4D2</accession>
    <name>A0A367J4D2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_004841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002267">
        <property type="protein sequence ID" value="RCH84788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4D2"/>
    <dbReference type="OrthoDB" id="2281380at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="6">
        <location>
            <begin position="15"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="45998" checksum="FE170D7AA5115AC3" modified="2018-11-07" version="1">MIGSFLRWKDITGVALIGITGLVIHFTNEDNIRLILLILWIIGMISLSIISNTNQVKPSSPAELNISDDQAPLLLKNALSLTTDQNSIYFPIYKPYSIFGEQLSHISEEDASQLDRMLTNDSLRHVSSFDSNAPSFYTRRTMTNTYTNHNSNYDDDYIEQDMTVTTHAYALALLPLPTTTDPLVALLSKQEDEELYDDLFIPRNYILPINHQLIKLKNWKLKTLDMSILLLGIADALLNTFLFMYAYSVLGISLSMISWLIVTNITSQSIVHCIVEKWFIHKLNLTLTTTLVHICLIICTIVYPCLKPNSPITNATLFVLQAVQAVSFQLIWSSAIDQIQFTVWNQYERMKERSKASVLFSSIGPAIGAIVAGIVLQSSLEEYSFLLKIAVVVLALSFVTTWGWTTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4U8</accession>
    <name>A0A367J4U8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NELF-A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002214">
        <property type="protein sequence ID" value="RCH84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4U8"/>
    <dbReference type="STRING" id="86630.A0A367J4U8"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23553">
        <property type="entry name" value="NELF-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NELF-A N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="32346" checksum="595CE8566D4D00AF" modified="2018-11-07" version="1" fragment="single">MALEENTVNYIKSIISKEPKTGWDSTHVAGKLSEDLVHLIAGSFKDFDKQTKLDILLSLLHLKSRDLIAIRENFEEICNIASKDDDKFVNIIADVLKTYPDTQQLNVNIEYWNEPDSVLNRVKSFITENGLHFHSPEYMLLDPKVRPVPAVASPIFTSWQPTVAKHFELTSNTEDLIHPINPGDQLIALVSMEERTEQVESSVVAAQKRPGLDISNIGKRMAVTSPTANIPNPINTFASPPTTPTSGNFPRPIRPPPRGPPSGGSSLFITKPRQRPPTGKPIQRSPSGSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J708</accession>
    <name>A0A367J708_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002028">
        <property type="protein sequence ID" value="RCH85727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J708"/>
    <dbReference type="OrthoDB" id="10267344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="20506" checksum="A1855D9DEDC1D86F" modified="2018-11-07" version="1" fragment="single">DKTDIYTDRQKEKADSKNRQLSFPEGSYVMVRDREQTNSLSPAFKGPYRVVRQTQGGSYILCDIDETLMSRNYSPEELKLISQDEIIPKDELYEIEAIIDHRGEPGNREYLVRWKNYSKDDDSWLTSDAFTDPESINNYWRKLGKSLNKKDEVVNKKGNDEKKRKQKLPSDYKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J722</accession>
    <name>A0A367J722_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine--tRNA ligase SYY-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002020">
        <property type="protein sequence ID" value="RCH85762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J722"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="96" mass="10634" checksum="F61EB94DCFCAD101" modified="2018-11-07" version="1" fragment="single">SLSGDQIIQAFKGDKHRFTQLEKSRLIGAGLDQIAAMTNAVKSKSEAQKKMKAGGFYLNNTRITHHQTTLTEQDLIDGKVVILRIGKSSFYLIEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J962</accession>
    <name>A0A367J962_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kti12, chromatin associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KTI12_1</name>
        <name evidence="5" type="ORF">CU097_008622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001860">
        <property type="protein sequence ID" value="RCH86467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J962"/>
    <dbReference type="STRING" id="86630.A0A367J962"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000827">
        <property type="entry name" value="KTI12 chromatin-associated homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="32087" checksum="CABACCBA690390FD" modified="2018-11-07" version="1">MPLIVLTGYPSSGKTQRTNEIKEYLTKRLAEENKSLRIHIIDDHSLHVSKAAYKDAREEKKARGALLSAVERLLSKDDIVIADGLNYIKGFRYQLYCVARAIGTPHCVVHTGVPADIAKEWNTSRNDEKYDDIVFDELVSRYEEPDERNRWDSPLFTIIYDDKQIPGDKLWDAVILKKPPPPNKSTVSKPVSSTNYVYELDKATLEIINAFVEQQKELGPGGMPMTVPRSTVKVINPSRTVTLSELRRLRKQFVTYNKMNTTLDVNRLGDVFVEYLNTNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA29</accession>
    <name>A0A367JA29_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CHO1</name>
        <name evidence="20" type="ORF">CU097_009021</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01001798">
        <property type="protein sequence ID" value="RCH86770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA29"/>
    <dbReference type="STRING" id="86630.A0A367JA29"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH86770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="219" mass="24160" checksum="04926E5448BCC286" modified="2018-11-07" version="1">MASTDKKNDTPREVDGHFSMVRNFYLADVITLMNGICGVQSVLSSMRYLTTNNVRDLYLSMILLPFAMFFDFMDGRVARWRNNSSLLGQELDSLADLISFGVAPAALAYAVGMRTYLDTVALTYFICCGIARLARYNATVALAPKDATGKVHHFEGTPIPTSLALVAWIAYFVKNGLYLDALPGSIVEVAQGWELHPFVMSFVVSGTLMISKTLRIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA64</accession>
    <name>A0A367JA64_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001795">
        <property type="protein sequence ID" value="RCH86785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA64"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="50" mass="5541" checksum="60CE58F4D6703D0C" modified="2018-11-07" version="1">MVPRSDNSAHVELSKRDIVGTFAANPQELSNEDIMLLQKADEVITSTLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBK0</accession>
    <name>A0A367JBK0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_009388</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001701">
        <property type="protein sequence ID" value="RCH87229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBK0"/>
    <dbReference type="STRING" id="86630.A0A367JBK0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH87229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="254" mass="29122" checksum="5F096D84ED97DF81" modified="2018-11-07" version="1">MSRQAITQPFHSDYYNSSPHFSASSSPSLSTSASVNSDLNRKDSKRNNKKQYPCDKCSKIFNRPSALTTHSYTHTGEKPFQCQSKGCGRRFSVLSNLRRHLKVHQKLTDSCKLSSVARLRFVRQLIERSETMLAPRQDKIEPKYPLLPQLQLPQPPSPSTPMSWHNFRPATFECHHCMALPSLGLHEHNHYLQPDNCFMYAENQLNPLCLVTDIVKRRAPSYTPYCHHEYYSDISTSSNHQQTGDTSIPFTYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCB7</accession>
    <name>A0A367JCB7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001627">
        <property type="protein sequence ID" value="RCH87583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCB7"/>
    <dbReference type="STRING" id="86630.A0A367JCB7"/>
    <dbReference type="OrthoDB" id="5597995at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="471"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="846" mass="96100" checksum="9D82A780AFB1CAD9" modified="2018-11-07" version="1" fragment="single">NVSTIIQPTVKSTPFLTPRAPTNKTIYNIGLLFPNVSTLTNKNDMYIRNAVVTSELAIRMAVESVRDKNILPDIELNITRYYSYEDESSLSAIETFKMVESNVDAVIGDADTDLTRASASITSLFSIPQCSAASGTFSLPDRDAYPFFFRTVGSITTHAYALGAWMKNMGWQTFSLLYSADALGDRVADILSDQGEQYGFYYAQSYRFSHATDESIEQALTELNRSGSRIIILAFSRPYQQVNVLRKAREMGFMSKGWVWMVADDLADNFLQNIKDDDDGDAVTAYNGLMYISTLWNLTGLPAFDEFQAKWRQQPVPSDYSDPSNWTTTSLNYGAAQAYSCLELLTLGINKALDQYSGGREKGLQDLASDTFNTSSMTPMFYNFNYSGPAGNLTFTDTGDLQKGYVTQYQFDMPYFQVFYLQNGIAVPYANIKIDSYESINDRIIYPGNTQEKPSDIAIHQYINPTPTSPLGIAILIVCSVGLFFCLLMAILIFLHRHLKPIMISSPVFCYLQLLGISMCYITLILLVRQPTPATCVSRQFLFCMGFAFVVGSIIAKNYRIYKIYQNVFTIRTSRLKSTYLLRLVGIFQIFVVVPLAVWNIVYRVEVVSYQLFQTDFCWVCEYPTAENGQWGRFNLAQMFVLIWLFLLILTACFLAFKTRDVSSKWSETTQIAYVSYNLIVSASVMVPGLLLGNDYYDISLYLYVSSLMFGSTFTLITIFIPKFVIISRHILQNSKKINIYRMNSDSQNQMSVHSTNSMDQNIQLNLVAKNMYDFTVQAHEGILPVKKMAKFDFLSIWTLKHVVLVPFKKYFILSEVSTQLCHPTLFYLFCVEIRRECHCLPLCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDB0</accession>
    <name>A0A367JDB0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COX10_1</name>
        <name evidence="13" type="ORF">CU097_008719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001565">
        <property type="protein sequence ID" value="RCH87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDB0"/>
    <dbReference type="STRING" id="86630.A0A367JDB0"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="356" mass="39836" checksum="C9DD57020D150AC4" modified="2018-11-07" version="1">MLQTNLIRQITKRHVNPTRIFATYSLLQQRHHNQRVTKFKVIEPPSMAKLPVLYKELIKFKLAGLVALTAMTGYALAPGESTVTTLLATTVGTGLCIGSANAINQWIEVPYDAQMLRTRNRVLGRRALSQVHAFGFGLLTGVTGVTMLATCVNPITAILGASNIALYTLVYTPMKRSSIANTWAGAVVGAIPPMMGYTAVTNNLLDPAAWVLGGLLYCWQFPHFNALAWNLRQDYSKAGYRMMAVTDPKLNARVSLRYSLAMFPLCFAVPYLDLTSYWFALDSSVVNGALLYGAYKFWRKSNDKSAKQLFFGSIVHLPVLLALLMIHKKWNLSSHHRTKEEEEIEEIIEWVIEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDI3</accession>
    <name>A0A367JDI3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="10">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="10">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="10">PHB:PPT</shortName>
            <shortName evidence="10">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_008486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
            <orientation evidence="2 10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01001592">
        <property type="protein sequence ID" value="RCH87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDI3"/>
    <dbReference type="STRING" id="86630.A0A367JDI3"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="400" mass="43981" checksum="B4570BA0E2E3F9B4" modified="2018-11-07" version="1">MFLQRTFSLTLGKAARCHNLSLLRALGESNCQNFSTLSAYRLAKPLRNNSTLSLFHQKIKTNGPLIPTVYHQKHWTSTITVKQDEEPKEPARVLYNNWLDRLPAKLAPYAFLTRIDKPIGTWLLFWPCAWSISMAAYHTGSSIMDAASMITLFGIGALTMRGAGCTINDLWDRDIDDKVERTKIRPIAAGLISPKQAIGFLGLQLSVGLAVLTQLNMYSILLGASSLSLVVTYPLMKRVTYWPQTVLGLAFNWGALLGWSAMTGSLDLSVAGPLYAGGVCWTLVYDTIYAHQDKKDDVKVGVKSTALRFGEKTNQWLTGFSAAFVSSTAVAGYMNGQGLPFYAISVLGTACHLFWQLKTVNYNNPADCWAKFKSNTWTGAILWSGIVADAAWSSSQLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEF0</accession>
    <name>A0A367JEF0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_000512</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001503">
        <property type="protein sequence ID" value="RCH88249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JEF0"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000002">
        <property type="entry name" value="cytoplasmic dynein 1 heavy chain 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="95"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1519"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="357"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH88249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1806" mass="206788" checksum="C73D8195A4F12622" modified="2018-11-07" version="1" fragment="single">DRLVDEEERKWTDDMIDSIANKHFPSINHEEALERPILFSNWLSKHYIPVKREQLRDFAKARLKVFYEEELDVALVLFNDVLEHVLRIDRVFRQPQGHLLLIGVSGSGKTTLSRFVAWMNGLSVFQIKAHNKYTGADFDDDLRTVLRRAGCKGEKICFIMDESNVLDSGFLERMNTLLANAEVPGLFEGDEYASLMTACKEGAQRDGLMLDSNEELYKWFTQQVMRNLHVVFTMNPPEGGLASRAATSPALFNRCVLDWFGDWPDQAFYQVGMEFTKTLDLDMPNYAAPLNFPIAYRNLPIPPSHREAVVNALVFVHQSLYEINAKLSKRQGRYNYVTPRHFLDFISHYVRLYNEKREDLEEQQRHLNVGLEKLKDTVIKVEELRKSLAIKKNQLELKQNQANEKIKQMVEDEKEAERKKADSLVIKNNLKIQTQEIEARRAEVDNDLANAEPAVKEAEMSVKSIKRQHLTEVRSMSNPPEAVKLTMESVCIMLGHKIDSWKTVQSIIRRDDFISSIVNYNTEAQITKQLRDFMHKNYLSNPNFEFDVVNRASKACGPLYKWVTAQCNFSAILDRVGPLREELNQLQRSSEETQLQAVEMDKVIADLEVSIRRYRDEYAELVGETQIIKAEMERVKSKVDRSITLLSSLSSEKVRWESASQAFESQMGTIVGDVLLAAAFMAYGGYFDQQYRDILIQKWMDHLLAANIQFKHEVSLTEYLSSADDRLSWQANSLPADQLCIENAIMLKRYNRYPLIIDPSGQATNFLINEYKDRKMTVTSFLDDSFIKNLESALRFGNPILIQDVEHLDPILNPVLNKELRRTGGRVLIRLGNQDIDFSPAFTLFLSTRDPSVNFAPDICSRVTFVNFTVTRGSLQSQCLNKVLKAERPDVDQKRTDLIKLQGEFQLKLRHLEKSLLQALNESKGNILDDDKVIDTLETLKKEAAEITRKVDETNTIMQEVDQTTAIYTPLAHACSSIFFAMEQLNLVNHFYQFSLDFFYEIFEYVIHANPNLKGISDPDRRLEILSRDLFSAAYKRASRSLIHEDYPMYAVLLCQIRMRGVQENVDDTEFDFLLNGGDSVVGNTVTAASLNLPSFIPDEIAQRIKEFSNLSCFSHLVNHVSMNEDVWKQFMEHNQPETIVPLCWDGAGTNNSVDALRKMLIVKCFRPDRLLPATTIFATEIFDGEFMNTGELNLQQIVTEEVGSSTPLALCSVPGYDASYRVDNLVAETNNRCTSVAMGSAEGFGLADQAISAAIKTGTWVMLKNVHLAPAWLGQLEKKLHSMKPHRNFRLFLTMETNPKVPVNLLRMSRILMFEPPPGIKANLQESLRSIPPSRLSRGPTERARLYFMLAWLHAVVQERLRYVPLGWTKVYEFNDSDQDSAFNTIDKWLDSASAGRANISPEKIPWDAIRSLLKQSIYGGRIDNEYDQRLLDSFVNTWFKPECFDIDFEVVKGGESQKGLTAPDGIKMDQFLDWVNKLPDREPPTWLGLPSNAERVLLTLKGNHMLNKVRKMKSLSDDDEAAYSQDGGQKASGAPSNSNQPAWMRALSASITNWLALLPSTIKTMQRDSHGIMDPLFRFFERENQIARNLLRVIREDLMSLQKVCAGELKQTNHLRQLLTWLNKGIIPDHWKRYKVPKNISLNAWLADLKTRLEQVESVAQEQTFEHVDIAIGSLFTPEAYVTATRQATAQKYKWSLEELILDVDIGKCKQMDSIGYHIHGMKIEGGIWKENEIRLTSEPSNKLPNTTIRWIRKDQKEDNENMVELPVYLNSDRSDLLFTIRTCANKEEKDRIPQRAVAVVISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFE2</accession>
    <name>A0A367JFE2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CNPPD1</name>
        <name evidence="2" type="ORF">CU097_009281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001430">
        <property type="protein sequence ID" value="RCH88644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFE2"/>
    <dbReference type="STRING" id="86630.A0A367JFE2"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="19642" checksum="7834EDAD41BBBC9E" modified="2018-11-07" version="1">MFATVSSKSPEALLSFTTNTATTLLPINNNNRRKMYNKYRYNNRQLPPLNEFIANVFKRSKLSPCVCLVSLIYLQRLKSCLPSHACGQVDTPYRLFLAAILTASKFLSETGTCLTSQAMVVMTDYAYSSKDINMMERSFLGLIKYNLFVNVEAIKDYLAIHGKVLEMDLIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGP5</accession>
    <name>A0A367JGP5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">POL12_1</name>
        <name evidence="8" type="ORF">CU097_000590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001354">
        <property type="protein sequence ID" value="RCH89066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGP5"/>
    <dbReference type="STRING" id="86630.A0A367JGP5"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="7">
        <location>
            <begin position="198"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="6">
        <location>
            <begin position="318"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH89066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="459" mass="52365" checksum="BF96F702CF36AFEE" modified="2018-11-07" version="1">MTARYSETAIANLYGLNSSDREVIQEIGSICQIFSMTPEQVKFKWEAFALNANISLTPSAAYIRLLKNNLQREFNRTLKKRRTGGVSTNERIVTKRAVMPVDLSAYGLDFTTTHDDLDTATHVSTVQDSDTKLSPETHRFLNRPEPYHLDGQYNGQLLRRGIVVDDHPQISLKYLQKPIEPYRYMFEKIRERADESNDRLDYMGEMLSNYYQKTFSNPVRQNQETIFAFGRICSDTNEGKLNEQSVLLETSKELGMGKRVRLDIERLQDYALFPGQVVAVEGINHHGHSFKPPVPPKIDSSKLEFVNNEGKPLEMITAVGPFTLDGDLSFKPLEALVQKCIEDRPDIVLLMGPFIPATHPMIARGKISTSPEDLFRQQIEVRLKNLLDTCTNTQILLMPHANDMTHTYPLFPQPPFKNLQHDPRIKLLSNPSNISINGHVFSIANIDILFRLAKQEVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGV7</accession>
    <name>A0A367JGV7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001336">
        <property type="protein sequence ID" value="RCH89170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGV7"/>
    <dbReference type="STRING" id="86630.A0A367JGV7"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="436" mass="50456" checksum="1A0716EB2EB21BE5" modified="2018-11-07" version="1">MKILIDFNKASIFYVSFLSLLIFHILDYHQNITTKSLSSLSSSFNQSIQPFPTFDQYPIHSDEKYITFFTHSGFQNQLIQVENGLLLAWYLNRTLILPKAILGESFGWNRFNKLQQHHILRETNQCIKKTKCPKRFALVSFDQLVDLSWARQHVRIIDREQSDLGWLQRRFGIETKDNIHSEVGTFVNGDILFFKDQSRYDWRFFDTSTKHRFMGRYNGSLEISALKERKEKLIHFTSLFGTGKFSIKDPNAQQFFNQLRQTITYKHPAVLKMAGIMIDRLGGAGNFVGAHLRTADGLFVEAIPENINNIIQKINVSSSFNEPPTLSTCVSLAKQNQTTLVFLATDAVRPRNNPIFHVLWHHAPCTFTLNDILGPKDPLWIYMDQYKTRHSGESMRKYLIPLVDAWVAGRGRSFIGSKGSTFSGYIRRLHQTFWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIJ7</accession>
    <name>A0A367JIJ7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_011205</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001227">
        <property type="protein sequence ID" value="RCH89792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIJ7"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="14">
        <location>
            <begin position="401"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH89792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="56574" checksum="3B10D79AB50846FC" modified="2018-11-07" version="1">MVTERTPLIAIYGGSRRWDKYAHGSIIFGLVLFIALIGLVLVRIPFNVFTFHPIFMTLFIVLLTEGIALLQPTSTSEEKRKGLYYHALIQSTSYLSAIIGFSFIFYNKVISNKSHFESLHGKLGLFVFVYLFIQLLFGITIALTPTLYGSIDKAKSLWKHHRILGYVLLLLVWFTSQLGVRADYMYNNLYDTNLIYLHWLSLIFVITGLVYRIRTRKWGVKCTNLNYPKAMVNTTTGTASRDYICLHAWNRDVAAVLNFRHILYGLRENQKKKKRPGRFCIKSFFGYRKVSKKERNTTIQLLWNKHKYQLNFKEFQHGFDEATVRDLKEKCKQVTNVPIASMKLQVSGANIKDDTATLTSVGVCRNSTVVLNGEQVDETEAKQVVSGNPEEYALVQRISKIVDTITAETEREITEFEQLAQVKELSDDEKKKLQDKGIYLSEKMMQCLISLDAVECPMGFETARQRRREGVRYSQKLLGRVDKAKAVMNTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK55</accession>
    <name>A0A367JK55_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001138">
        <property type="protein sequence ID" value="RCH90334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK55"/>
    <dbReference type="STRING" id="86630.A0A367JK55"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="495" mass="56584" checksum="88A8664AB02FE3B0" modified="2018-11-07" version="1">MSGQSTPNLYNDSSLLLRARKSDRDLVGYDIKEDKKPVYEVIEMGEVAKWDPNAKQNKRKWSLLQHKPYLALILCMLIFLGFIVNTRFQRKIPTRHQLFFNGTTYFDTTVILLSLDGFRNDYLDRKVTPNIENIGKRGISAEYMNPSFPSITFPNHWTLVTGLYPEAHGIVANEFYDPALGQYFIHKNESISSDPKWWKGEPIWITSKKQGKKSAVIMWPGSNVKIDSLSPDYYQPYAREITAQDKMDTVLNWLDLPMDERPQSISVYIPQIDQKGHGGGPNGGQLNSVLTDMDNAIGYLLKGLKQRNLDSHVHVVVVSDHGMAPSDPSRYIFYDKILSDESQSYLRPREAWPLLGLRPRDDAPEHIIDQIYHELQTYTETHDDVHFTFYRREEMPSRFHYNATERIAPIVIIPDVGYAIIRSTDKKAPKGIHGYDNLAPEMRAIFAATGPKISEHYGKGTRLSPFFNTELYAFLTTLLDLVPAPNNATLNGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKL2</accession>
    <name>A0A367JKL2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001126">
        <property type="protein sequence ID" value="RCH90409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKL2"/>
    <dbReference type="STRING" id="86630.A0A367JKL2"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="906" mass="98909" checksum="D65EEB8FD9BAC602" modified="2018-11-07" version="1" fragment="single">LLAGPVHVESTRRIVDKRHRMSHDNNNSNSNSNNNNNNNNNNSPLSENGPNRFGRKGRDYFSKEPSFRRNNDNDLLKKKEKTEDLASPFGKAEEDAPWSKSMNNGPLNNEFFKDESPFRSSFAGDLTAGLSTPPGIPPVRKPEDIKWFYRDTSGQVQGPFEAHEMQEWYKAGFFTPTLLLRRDDESVFEPLMTVIQKVGNDDQPFLTPRPSAAASDVFGSSEGLFGRSDKYMPFGGPTTPGGSIIDSFLSGSTPSPLYQNPYSSFGGSLLNNNRWNNGSQPLGSPAWLSQPSDLFGNAPTAGSPLGAAPLGLSPFIAQQQQQQPGLNPVFGSASSTPGLFEYQRVMNDQIGQQQQQQHYLQMLKQQQMMQMQQQFQHIKLAEHHPSQQQPQQAPPVPVSQPLMQQQQQQEQAPSYEHDKAQVPTEKTQVSPKSLQNTLKNISLDPIGSNHASPVLRTNNILTGGSGWGSVPGTPLASDAPSSPWGTIGASALPSKVTDEFQPKAPGTQSPRAPSSPKKATEKPKFKPIVESFTDIQAEEMEKEKAKEAAKATEPVKPKTAPVKAKTEAKTSAVVAPKTTIISLREIQEEEMRIAKEKKEKQAKATSTASTWVSTSSPTTTTATSLSTWSQPVVEKPLSLREIQEMEEKNAQNKKEIVPEVPIHTSSSSGISTISWGVVAPNKTVTPANGTTSSTAVWSAAVNNAPKKTLREIQLEEELAMKKKNATKAVKADTPTVASIVASSKPPVASTAISSTGNEGWTTVSHVRAPKPAPTPAPAPAPVVKEPTKWEPVKPAVRPPVARGPSEDFRRWCRKALRGLNPGVNEDEILEMLLSFPVDGSSAEIIEDVIYANSLRIDGKRFAQEFMRRRKADIAGRTDIVLAGLEEEDDDDFKVVTTKKNKKKTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKU2</accession>
    <name>A0A367JKU2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001104">
        <property type="protein sequence ID" value="RCH90553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKU2"/>
    <dbReference type="OrthoDB" id="2278325at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="33804" checksum="A60F438FFB946A04" modified="2018-11-07" version="1">MSNTTVTLTATITQRIRPTRTYLTATIATYTELVTQLPMQEWERQIYRGLPVILAFAIIGILTISISLCYLAYRIYNANTKKRYHRQDAERELKPKALSHVLPWFTHQDLQIEKSSNNNNNNNNNNHRRSNLSPTFVPIHTSLNLVPRSEILNDPERRRGVDELDMWEKKKQSKTTTQQVWKFPFTRAYPESSQESLHQIKRQNSFSQSSTITMQGASFHQNNRDKSDIVLTEHSYMEQSSPSQTRHSYAISLNDEPSSSRGKDIQMARKILEECKHNSSQWLHFSGSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL79</accession>
    <name>A0A367JL79_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_007329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001119">
        <property type="protein sequence ID" value="RCH90451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL79"/>
    <dbReference type="STRING" id="86630.A0A367JL79"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="521"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH90451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="647" mass="71933" checksum="A9ED324E07BB37F2" modified="2018-11-07" version="1">MMNTVENEHELIDVELWKTAAKQIDWFEPPTSVLGRRDGPNPYIWFPNGTLNTCFNCLDRHLPSLANRPCLIYDSPVTNTKMTLTYQQVLDQVQLLAGVLRSHGVHKGDTVLIYMPMVPEAVFGLLACARLGAVHSVVFGGFAPKELAKRIDDCQPKVVLTASCGIEPKRVIAYKPLLESALSMCRYQVPTRIVYQRPNQVQAELRRGDFDYYQEIEKVRAQNNAVKECVPVSSDDPLYILYTSGTTGQPKGVVRSNGGNAVVLRWSTEYVFNIRKGDTIFTASDIGWAVSHSFTVYGPLLTGATTILYEGKPIGTPDAGAFWRLVSEYGAKTMFTAPTAMRAIAREDPKGEMAKRYDLSKLTSLFLAGERSDPETLKWCQQLVGDHCTVIDNYWSTELGSPVTATCAGVEKNPRKAVKWGSAGRQVPGSIICVLKEDTLEEYKEPNKFGNIVLKLPLPPGAFPTLWKNDEGYKKSYFDKFPGYYDTGDAGMIDEEGFVHIMSRTDDIINVAGHRLSTGSIEQILISHPSVAECCVVPLADQLKGHVPLGILVLNRAHEDTKGLIKELIEATRRDLGAIACFEKAVIVPRLPKTRSGKVLRRSIREMVDGKPIVVPATIEDENTLFEIHEILKQNQLIPFKQKTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLH7</accession>
    <name>A0A367JLH7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001067">
        <property type="protein sequence ID" value="RCH90792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLH7"/>
    <dbReference type="STRING" id="86630.A0A367JLH7"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="265" mass="30483" checksum="95A05D80B881EB0D" modified="2018-11-07" version="1">MNEAQLNLSTKQKLEPFLLLSKSAKGIACCQLIMDALNAPGVFVFTELYESPNIVEASQLPQVIPYYQLLRIFLYGTFKEYQQQKHNLPTLSAAQIKKLRQLTLVSLSEHTQTLDYVFLLNELDIATVRELEDLIMDAMYDGLLTGKLDQRQQQLLVTKAIGRDVRPEQLDEMIETLGAWSMQTAKTLARLDANIAYLQETVQTNQQAKIDFNRQIEDIRKECRENSHSLSNEVLQEDGRSSRKARDAYNIRKRYANPFLTRCMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLN5</accession>
    <name>A0A367JLN5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001069">
        <property type="protein sequence ID" value="RCH90779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLN5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="23025" checksum="C866CCB92251A994" modified="2018-11-07" version="1">MPSVTETLDLEGGITILDVGCSSGAWNMASEYPNCIYHGCDIVDVTYKNVDVKQFTFSLGNVTNRLPYEDNTFDFVHMRLFVTCLRKDEWPTAISEVIRVTKPGGMIQLGEFDLQPQNDSSSLYYRILSFKDVTCDMSSDTYTVKMFIWDNLEVIKSMRRVLDSMLGIHNQKDLISFLKEYKHDLETKESVVGFAAVTVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLP3</accession>
    <name>A0A367JLP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">IMD1</name>
        <name evidence="22" type="ORF">CU097_007878</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 20"/>
    <dbReference type="EMBL" id="PJQL01001067">
        <property type="protein sequence ID" value="RCH90789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLP3"/>
    <dbReference type="STRING" id="86630.A0A367JLP3"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14 15">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14 15">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="328"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="391"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="415"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCH90789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="528" mass="56533" checksum="22A1BF068AD45D57" modified="2018-11-07" version="1">MSTFLDCSTANAVLKEYGRNDGLSVEALMDEQLSGGLTYNDFLILPGFIDFSADKASLESKITKNITLKTPFLSSPMDTVTEAEMAISMALMGGIGIIHHNCSAEEQANMVRTVKKFENGFITDPVCLSADHTVADVKAIKAKSGFCGVPITENGKLHSKLLGIVTARDIQFHKDDTTPLRDVMTTDLVVGREGITLKEANEILCSSKKGKLPIVNADGALVALLARSDLLKNQNYPNASKGSKSKQLLVGAAIGTRPDDKDRLTLLVEAGLDVVVLDSSQGNSIYQIDMIRWIKQNYPKLDVIAGNVVTREQAANLIEAGADGLRIGMGSGSICITQEVMACGRPQATAVYRVSEFARKFGVPTIADGGIGNVGHIVKALALGASAVMMGSLLAGTTETPGEYFYHDGQRLKHYRGMGSIDAMSQKSATGKDGNAATKRYFSEGDAVKVAQGVVGKVVDKGSARKFMQYLITGVQHSLQDIGCHSVNELKDKVFAGQVRFEKRTAAAQMEGGVHGLHSFEKKLYSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM52</accession>
    <name>A0A367JM52_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proteinral transcription repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUP1_3</name>
        <name evidence="12" type="ORF">CU097_004540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001070">
        <property type="protein sequence ID" value="RCH90771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM52"/>
    <dbReference type="STRING" id="86630.A0A367JM52"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="511"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH90771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="550" mass="60581" checksum="29B41DCC1342ECC7" modified="2018-11-07" version="1">MSVYNHRPMGPPTPSRLMELLDAVKNEYDQLAQEVMVCKSQRDEYEHKMNSQIQEMNLFQQNLMDLERTQQMIKKQYEEEIARLRQQLEQVQHSQHSGAPPQPPVGSATYGGPAGYQPQQPPPSLMDTKPPVHHPGYPVGPPPTASPHIPPNSAPAPPHPSAGTPYMNGGSPLPSNAPPPQLPRGGSLTKGGAGPQTPNEPLGDINPESVPANMKVEGQDWFALFNPKATRYLKVDLLHTFDHGSVVCCVKFSSDGRYLAAGCNQATYIYDTLAATRVAVLQDENAGREGDLYIRSVSFSPDGKYLATGAEDKQIRIWDITKKRIRGILSGHEQDIYSLEFSRDGRILVSGSGDRTARIWDWQTLRCLHELRINDVEQQDLGVTSVAISPDSRLVAAGSLDKVVRVWDAVTGQLLERLEGHKDSVYSVAFMPDGKTLVSGSLDKTLRMWQLGTGERGYDRSKNACIQVFTGHKDFVLSVATTPDGNWIVSGSKDRGVQFWDPRTGQTQFMLQGHKNSVISVATSPGHKPMFATGSGDNRARIWSYEPLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN62</accession>
    <name>A0A367JN62_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRE4_1</name>
        <name evidence="6" type="ORF">CU097_005867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000980">
        <property type="protein sequence ID" value="RCH91358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN62"/>
    <dbReference type="STRING" id="86630.A0A367JN62"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="265" mass="30098" checksum="E89231EB73DDEC75" modified="2018-11-07" version="1">MDHFPSRWGKPRSEAIDTYGTVPMPQTVPDQLAQSAYGPMTRTQNPLITGTSVLAFKYRDGIMMAADMLGSYGSLARFRDIKRLYPVGESTVVGASGDISDYQYIQHLLDSLMIKEHCADDGHVLGTPHIYEYLWRVMYNRRSKFNPLWNALVVGGLHKGERFLGYVDLRGTTYQSTTIATGFGAHLAQPILRRRVEGKEDELTEEEAVEIMNECLRVLFYRDARSLNKYQIAKITENGLHISEPYQLDTEWSFAESIRGYGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNP9</accession>
    <name>A0A367JNP9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRP45_1</name>
        <name evidence="6" type="ORF">CU097_002541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000954">
        <property type="protein sequence ID" value="RCH91548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNP9"/>
    <dbReference type="STRING" id="86630.A0A367JNP9"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="186"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="606" mass="68124" checksum="936DAD34CA3BF3AB" modified="2018-11-07" version="1">MASLSSLLPKPRQNLSSTSSAPQLEKQINQIITKATAHRIPPYGQRQNFRPRLPEDFGNGGAFPEINIPQYPLDMGRKDKASTERKGGALTLQVDSDGNVKYDAIARQGHNDDRIIHTSLKDMVPLKERKDVDVDKLVMDRPSEEEVMSVAEKTRQALERIVNSKVQALKPKNVVSTSGGNNKEPTYIRYTPANTGEGFNSGAKQRIIRMVDAPVDPLEPPSHLHKKVPRGPPSPPAPVMHSPPRKLTAKEQAEWVIPPCISNWKNTKGYTIPLDKRLAADGRGLQELTINDNFAKFSEALYAADRHAREEVRQRNLMQQKLAQKQKEAEEEKLRQLAQKAREERSGIKSSNTSTAAGNKGEPPSNANRPTAASLIANYDSSDESERSESEDESPVRRRTSDESDEEEAARERDRLRRERHRQLQRELRMSNMGAEARAKHLAREQGRDISEKIALGLAKPTLSKESMFDARLFNQSEGIGSGFKDDDAYQAYDKPLYNQSSTSIYRYRGENHESEVLGSTNAEDLERAIKQDKFGMNRKGFQGAEGNADASGPVEFEKETLGKPKTEQDVFGLDTFLNKAKKGKGKRAREDEDDFDSDEERRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP59</accession>
    <name>A0A367JP59_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000928">
        <property type="protein sequence ID" value="RCH91732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP59"/>
    <dbReference type="OrthoDB" id="2370938at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="128" mass="14532" checksum="058B7E6CFD7F9967" modified="2018-11-07" version="1">MYATVIQTIEGTYGIKKPRIPMDTITKILNIIQDVSTKTISGDKGIMQLIDLDFPSQETRFVKSIIQLMGKLPCNPISSDINESELGSRYIDPFLCGLFDDPDRGMFLRWTNEITDVFDEIVIIITRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPK8</accession>
    <name>A0A367JPK8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YCK1_8</name>
        <name evidence="7" type="ORF">CU097_012715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000916">
        <property type="protein sequence ID" value="RCH91819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPK8"/>
    <dbReference type="STRING" id="86630.A0A367JPK8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="38176" checksum="671E38234D2960C9" modified="2018-11-07" version="1">MECKQVIIKHKWLILYKIGEGSFGQVFKAKDIKSNDFYAIKRELRDSPQLYHEFKFYKTLKGGPCIPNCYWFGQHDGFNCLTLDLLGPSLKHLQEKLKEIPLRIVVQIGCQLIACFKHMHDLGIVYRDIKPENFLFPYKYSFSSFSSSLSSSTSPPSPPSSSTLSVPPLPLYIVDFGLAAWWRNPRTNKPYPEAKYIKYKTGTARYASVRVHKGHSHARRDDLESLGYMLLDLLCGDLPWSGVVARSCKAGWDRIRKIKEDTSLFDLCIGLPVGILHFIDYTRKLEFYDRPDYDYLISVLQESLPFGSYSTLVKPQTQDLFDLPSFSKSIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQL5</accession>
    <name>A0A367JQL5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000867">
        <property type="protein sequence ID" value="RCH92175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQL5"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15205" checksum="1189253856CCEDEA" modified="2018-11-07" version="1" fragment="single">SGEAELAIGYIGTSWITANEKDKLEYYVYRDDDMDDKHRPHLEIKKKADEMVDVLKSKESHCWIMENGKDIVGTVILKCDQREGKIGYLTGVNSEIRRSLVKNAIQFAKSNKIEVISKWDESTKWTSDNNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQU9</accession>
    <name>A0A367JQU9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL23_2</name>
        <name evidence="5" type="ORF">CU097_013072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000847">
        <property type="protein sequence ID" value="RCH92308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQU9"/>
    <dbReference type="STRING" id="86630.A0A367JQU9"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="14922" checksum="C76DB8F306FB7BBC" modified="2018-11-07" version="1">MLTISIVSVSGTKYRMTLGLPVGAVMNCADNSGAKNLYVIAVRNIKGHLNRLPAAGCGDMVVATVKKGKPELRKKVLAAVVVRQRKAWRRRDGVFLYFEDNAGVIVNPKGEMKGSAITGPVAKECADLWPRIASAAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQZ8</accession>
    <name>A0A367JQZ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-mannose transporter</fullName>
            <shortName evidence="9">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VRG4_2</name>
        <name evidence="10" type="ORF">CU097_010574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000847">
        <property type="protein sequence ID" value="RCH92305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQZ8"/>
    <dbReference type="STRING" id="86630.A0A367JQZ8"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="380" mass="42123" checksum="B3FDECC93911882F" modified="2018-11-07" version="1">MGFVRQEKGQSITLTVNTGNLLELPNNNQSSVVASNKVSSVSPAVKAGLPIFSYCIASIVMTVTNKYVVSGDFNMVFLLLTVQSIVTILFLQAFKFLNLIKYREYNHEEAKKWYPIVIFLVAMIYTGSKALQYLPIPVYTIFKNLTIILIAYGEVLWFGGSVSSLMMLSFALMTLSSVIAGWNDVFNALDSVLNVTLAEAKIIVGYFWMAVNCLSSAAFVLYMRKRIKLTNFKDFDTVYYNNLLSIPLLLLPSLLLENWSIENLEFNFPPEERQARIWAMIFSGVSAFGMSYASAWCVRTTSSTTYSMVGSLNKLPIAISGIVFFGDKATFGNVTAIFMGFVAGIVYSYAKAFPKSAITVTSASSQSYMDASKDNEKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR83</accession>
    <name>A0A367JR83_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000824">
        <property type="protein sequence ID" value="RCH92460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR83"/>
    <dbReference type="OrthoDB" id="2287734at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="6833" checksum="D96945BCACEE693B" modified="2018-11-07" version="1" fragment="single">YNSADGFVALTSVLKGEAKWDAVAFVVKDKLVAPLFVELSGGTGFNASKGKESGEVIGKIAEDKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRA4</accession>
    <name>A0A367JRA4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000823">
        <property type="protein sequence ID" value="RCH92473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRA4"/>
    <dbReference type="OrthoDB" id="2290457at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="116" mass="13353" checksum="0A9F9BC918F827AF" modified="2018-11-07" version="1">MLEMMVANRVKKPRICALVVNGSRCSTFVLDLVHETVYSYYELAEFELVTKIDNVDNYWKVVKSLLQVKAKLLEVKKDIVSSISAIINGDAKDDKTKLMEWTRLSFGKPYKIEYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS67</accession>
    <name>A0A367JS67_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000776">
        <property type="protein sequence ID" value="RCH92812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS67"/>
    <dbReference type="STRING" id="86630.A0A367JS67"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF8">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="47"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="261"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="46657" checksum="8C50394BF30E9B19" modified="2018-11-07" version="1">MNPRLIQRRWYTSTSFKQLGLSLSTCQRLQTQFHVTQPTRAQQEFIPHLLEGKRDLLLRDATGTGKSFGIALSLASLVSATSGCVHSLYIAPNQELATQIGQWIQQLTPHAHQVQVIATSLTEQPPITHTVVGTPNRILEYINHGQLPVHALDRLILDEADQAFALPRKYAPLREKERRARHPKPAEQLLEKIKHGKHQTVITSATLNRPLRFFLSQRGFVRDPLFVDLQTTTVGIKHHCLLVSDDRIRNIRPELIKQDLDVKQKLDFDDTDDRLIESIATLHEIESVSNGILFIDSTISVEAIKERLAEYQVQAHDIKEYSSLGPRPGALWVATEFTARGVDIPGASHVFILGKPSSTAAYLHMAGRTGRLSPSGFSQGKVFSLVRDQGWTEAKMKNMFELLNIPVEHYEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSE6</accession>
    <name>A0A367JSE6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000768">
        <property type="protein sequence ID" value="RCH92873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSE6"/>
    <dbReference type="STRING" id="86630.A0A367JSE6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="269" mass="31314" checksum="D57A002580D65124" modified="2018-11-07" version="1">MRRAKSIYEKKNNSRRRSWFNGPFFSMFSSEPPSPERRPSLELNKQRSQSLNEERPSLRPKISRILSRATRRHHKKPSLDTPSVQDTLEHQDTDEENEDKDLLQRHLLKPDDEEADRIQLKNDLVKLAFEGEFSLPFDYRDLDYARILDVGCGPGSWCIDLAQKYPKIEVIGVDNDDMFPLAHVLPPNCQLIVCNVLNGLREFPDESFDVIHIRFMVLSLTTPQYKKVVKDCWRLLKPGGYIEILETDLIIYSAGPLTQKMNNESTYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT29</accession>
    <name>A0A367JT29_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000752">
        <property type="protein sequence ID" value="RCH93009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT29"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="235" mass="25555" checksum="2E0B28F6D90035CE" modified="2018-11-07" version="1" fragment="single">HTRDDDLIMSPPIYRTGSQKYRRRMLQLTEPPVSELDQLTYNGTVFTSKNTNKTTTASATTTSSNSLREYAKQPSAHVVMPPTALTSARLVADTFSIISNDTAQPKEIDICAKRYSMMYLQQHQQPTPPPSPPAIAASPQKNSQVEYSIVPSPAISPIEEKALSLSPAPEKKIQAVSSQSPPPPPPPVLELKQDHFIKPKETSPSPPPILSTGISTTASIENAPSSPFKARSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT80</accession>
    <name>A0A367JT80_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HAS1_4</name>
        <name evidence="19" type="ORF">CU097_010689</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="14">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01000747">
        <property type="protein sequence ID" value="RCH93059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT80"/>
    <dbReference type="STRING" id="86630.A0A367JT80"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="85"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="275"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH93059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="504" mass="56828" checksum="159467A59F946D40" modified="2018-11-07" version="1">MVTAVENKKRKRSHAEKRQNKKKKQESENEESVSIEEQSKQNENSEQVQESQNLEFESLECNENIKKAIKDMGFTQMTQVQACTIPPLLEGKDVLGAAKTGSGKTLAFLIPAIELLVRKKFKSRNGTGVIVVSPTRELAIQIYGVVEELCKYTEHITHGIVIGGANRKTEADKLVKGVNLLVATPGRLLDHLQNTQGFVFKKLQALVIDEADRILEIGFEEEMKQIIKILPTDRQSMLFSATQTTKVSDLAKLSLKGDPVYINVDEQNDTSTAEGLEQGFVTVEADKRFLLLFTFLRKNQKKKAIVFFSSCNAVKFYSELLNYIDVPVMELHGRQKQQKRTSTFNEFCSAEKGILLCTDVAARGLDIPHVDWIVQFDPPDDPRDYIHRVGRTARAGKQGRSLLFLLPSETGFLKYLKDAKVPLNEYQFPSSKVANVQSQLEQLIEKNYYLNQSARDAFRSYLQSYATYSLKSIFDVNKLDLMKVAKSFGFKVPPKVNLAIAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTC1</accession>
    <name>A0A367JTC1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DIA4_1</name>
        <name evidence="11" type="ORF">CU097_010764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000736">
        <property type="protein sequence ID" value="RCH93135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTC1"/>
    <dbReference type="STRING" id="86630.A0A367JTC1"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000078">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="157"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="44754" checksum="83F50132A5A0E99E" modified="2018-11-07" version="1">MDQFAVLYQKRLDIYNQLKELNAERNKLSMAVKTAKGQEKQDLIERGKGIKIKAKAYEDDLKEVETELLAKGLMIPNTTHPDVPIGPEENARVLKTVGTPRTGNNLKDHLQITADLNLLDLEQAAITSGSSFYYLQGMGAFLELALINYAMHKAASKGFFGVLTPDIVRTTVAYGCGFQPRSDENSQIYHIQSNNGSQLCLAGTAEIPLAGKFAEKTFKEAQLPQKLVGFGHAFRTEDGGRGVEPKGLYRVHQFSKVEFFAVTTAEQSEAMMEEIRSVQEDIFSELGLCFRVLDMPTEELGASAYRKYDIEAWMPGRNSWGEISSTSNCTDYQSRRLGIRYRKAHNENQQLFCHTLNGTAMAVPRVIIAILETFQQDDGTVRIPKVLRKWLPGEPEYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTD7</accession>
    <name>A0A367JTD7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_012162</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000728">
        <property type="protein sequence ID" value="RCH93203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTD7"/>
    <dbReference type="STRING" id="86630.A0A367JTD7"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000258">
        <property type="entry name" value="Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH93203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="316" mass="34577" checksum="013B3E2CA01E95C3" modified="2018-11-07" version="1">MLRLNKLSVSKRAFSTSSLLFKDIKNVTIIGAGLMGSGIAQVAAQAKYNVTMVDTSDAALENGKNIISSSLKRVARKKFADDEAKQKEFINQTMSNIKTSKDPNEAASSSDLIVEAIVENIDIKQKLFKGLDQAASADTIFTSNTSSLPVTLIAEATSEERKKRFAGLHFFNPVPAMKLVEIVRTDKVSDSVIDALNQFSKNVGKVPVNCKDTPGFIVNRLLVPYLMESYRILDREEASIEDIDTAMKLGAGMPMGPLELSDFIGLDTMKFIVDGWHKEGKIDPALTQPSKALDKLIAEGNLGRKTGKGFYDYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTI6</accession>
    <name>A0A367JTI6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000725">
        <property type="protein sequence ID" value="RCH93226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTI6"/>
    <dbReference type="STRING" id="86630.A0A367JTI6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF8">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_82, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="47363" checksum="7038653B584C9E61" modified="2018-11-07" version="1" fragment="single">SVEAIMKKFEELERIEKEFSAMKVDNPSEDEQKNLTEEQLEEIFKRTSAFTVKSTTIDRDTIEDLDALDLWEIEYKDGDTNEFYEEDEYHYVDESFWDEEFGEKPARKGKQIRSLREQKPLVAKGRGVDRESIIAKYKIMQVQVQDRNGNYFTIKKRVSNVDPSLPTYVKIPPRPIPMSWAHSIKSISKCPKEIVGSRYYEVDSIVSTDLTQYGTDFNAVYMDPPFLLPGEEPVAGKITIDDFSALNVADIVKTGFLFIWLEKEWIQKVVTITAKWGFKYVENFCWIKKDVNNQIHKSPYRYFNKSKLSLLIFRKEGDIELRHQRNPDCVFDFIRPKLPDEISEKKPPFMYKVIETLLPTANYHIENNPNGERLLELWAKKGQRRQGWTAVVEKLKNTTACNTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUS3</accession>
    <name>A0A367JUS3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000671">
        <property type="protein sequence ID" value="RCH93657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUS3"/>
    <dbReference type="STRING" id="86630.A0A367JUS3"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="194"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="410"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="700"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="90062" checksum="ADF5DB2A75DB3A69" modified="2018-11-07" version="1">MTSLKSSSSSSSHSSNSRSPSLNTTSTTNTFLSNSPLPALSITNKPSNGTSLYHTCRSVLEKLSLVPNMEYYIDYTTDDDTTPLNKLWAICRRGFPLAALFNALDPEEPLSVDPSCTQINECKKSIYHFIVACRNQLGIHEDDLFTLSDLYKDNTNGFVKVVNTIDIILQMLEERGVITSINHNRNSFNEPKDARDKVVLELLETERKYVQDLEILQASVDDDKKKAISNLFYLQNYKRELQLQEILNPDTVHYLFGNLNTLVDFQRRFLIQLEEMAEKSPEDQDFGSLFIQNEDSFTVYEPYCSNFFSAQDLVVQEAPKLQKLADILNPIYELPSMLIKPVQRICKYPLLMHQLIKATNPSWPHVFRMEQGLTSIKRVTEKVNETQRKLENIQIVDEIKNRVDELRRGEIGTYGALLLHDKLFMSQSDAPEKELLVYFFEKTILICKESKDSTKNKPAKSNTISIKKKRRGSLQLKGMIMTSRIVKVRNHSSSGSWCLTIDFKDHEVDHVLFRFRNEEQMKLWESTLQRHIRPMKSNVSNTQLMSMKGTNLTEVPPFLRTDDDSSSDYSDQECDSPTMPRPQKKYSIPRHITDQPPRTSSHHHMQHLHDYPASPPPSHPSSPRAMDEYPPYLMNRSQSQSVVPGQPLLYTSRVRSQSSPNIKQRQQQQQHWDEPTPPTSQFMNSKTLYNTAPPSPLDQPLKLKLNFNDGIYVIMTGLDISYSELVDKVDRKIRLIANLQPADVLRLKYQDEDGDFITINSDEDVQMAFENRGATNTINLFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUT3</accession>
    <name>A0A367JUT3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SNRNP25 ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000667">
        <property type="protein sequence ID" value="RCH93686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUT3"/>
    <dbReference type="STRING" id="86630.A0A367JUT3"/>
    <dbReference type="OrthoDB" id="72819at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17058">
        <property type="entry name" value="Ubl_SNRNP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040610">
        <property type="entry name" value="SNRNP25_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18036">
        <property type="entry name" value="Ubiquitin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNRNP25 ubiquitin-like" evidence="1">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="17472" checksum="51E8F7FA00E3FCF3" modified="2018-11-07" version="1">MSEHLAEELKEKINQLLNDELLSDVSPSLSEKEIDSLIAVEKGQAFRIKVEREPLRPINLIVGQSYSVKDIKKLIQVTVERMEKEEKTGRKRRISWKFIWRTYCLVFDGTKLLDDNAIVSQLGIKQHSVLKFTRLPHQKGKHSKAWKWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUU5</accession>
    <name>A0A367JUU5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000667">
        <property type="protein sequence ID" value="RCH93687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUU5"/>
    <dbReference type="STRING" id="86630.A0A367JUU5"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="341"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH93687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="409" mass="48235" checksum="474614D2C940C225" modified="2018-11-07" version="1">MYFYIQPAVSFDYPSLSLDDYAQLHRLLRQERQAAMYHAQQQRRIQRALYNLEVMTELYRRRQEEERAIRAYYERKERQRQELIRQQQLIQQQQQQQRYLAALEEHYMNYYYPQKHQEPFAHHSAFYQEPESEEEEDEDDNEDVRTQQLAALVKLIFGAQDETTRHEEPAHDAPLYKESQFGEVKQQVPLEAKHNEVKHEEPETAMEKAESHDDMALDDTETKDTDHNLDNTNDPMEEDLDDEMTSADEDMPSLIEPTENIKGLVSEILDASEENPSDFSVFPEEDPVKLAKYEALSRIEQELKDIQQKHEKHILGNTLDFPLSSDGRPLSPDTLTATTANNREFLGYEDEIMKILLKLDTIESDGDEDIRNERKNLVKQAESLLETLDEYKQREWERVSSASEDEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUW8</accession>
    <name>A0A367JUW8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calcium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CCH1_4</name>
        <name evidence="15" type="ORF">CU097_009807</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000661">
        <property type="protein sequence ID" value="RCH93740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUW8"/>
    <dbReference type="STRING" id="86630.A0A367JUW8"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="270"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="682"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH93740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1049" mass="120119" checksum="E8D65F946CD6F88A" modified="2018-11-07" version="1">MGYGYPNMSLFKTLGALRPIRLLSIIPGTAMILESLELSWDVLLAVSGLILFFLILFALLGLVSFQGAFSRRCYYIGNDGSLMQIEPVRYCSGYRNGTSVMGPYNIQTGTHDYYGRHGYMCVSGQMCVEDPNNNPQYNFVNYDNIFSSLLSVYTFVSLELWTDLMYQTQDADSSIAALYYCLGVYIISFVMSFLLFAVITSAFARVRQFGSGSAFTSKEKGYLILRDTEEANTNEDNDPIWMFDYHRDDFRKGLSTLKLRWLLVHLVRSQAFYYFGGFLVLLDLIFMCLRSYTASESRIELINNAETAFTFIFAIEIVIRMVGATSWMNFWSSKRNVIDLFIAITTCVIQLPMIQDSAAYKYLTIFQICRCYRLFLCIPRVQRLVLAALGTGENVFNVMVFLILATALCATMFMQMFGGDFNDLFSYTDAENRFDTFWQSFVSLIIVYTSETWTEILYNAMASQAGKGSIYAAIALSIYFAFGRYIMSGLYIAVVLENFELSDDYIRRYQIKDYIHRHRFKDFGKTETILMRIFYPLYHLEDKKNLHIPKLPANLTASLSKADITELLADIPRTRRNAIINATGPSVLEKKFVSLYTKVRANMPLLKKEENAKPTPSSTFVLDNDDTPDDYDIVASEENREAMKERATIAHSLLMFSDRSRIRYYCKKLVGSSVDGQAEKRNLFNWIIMICVFVSIIMVILDEPSTRMIRKDTIRQSTYNTIEIALSIIFIIELIIRIIADGLLLTPNAYLRNHWNQLDICVILLNTITIFMGTEQAPRGLSTLRSLRILRLIRYFNGIRDIFVSLFYSFPLMLDALIFTLLVLIPFAVYGVNIFGGLMWLCNDDSVLSRGECIGEFTNNIGDDDPSPSILIPRVWQNPQNGFYSYDNFPSALQHLFSLTSTEGWVDSMFSAMSTPIEPDIQPSFDWNSATVYHGLFYIIFMIISQGTIQLFVGVIIEKFKERSGITTLTTAQRQYCDLQRMLANVKPTIKVFPPQSKIRRFCYDLVIEKDGMFNKVMMSVIILNACLLASEFQNEPDWLSYVQGKSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW84</accession>
    <name>A0A367JW84_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOS2_2</name>
        <name evidence="15" type="ORF">CU097_006748</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="PJQL01000610">
        <property type="protein sequence ID" value="RCH94158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW84"/>
    <dbReference type="STRING" id="86630.A0A367JW84"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="58"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH94158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="479" mass="55128" checksum="3883F8D94A12AB60" modified="2018-11-07" version="1">MPRKGFVDDDSMSTFSEDHYSTQKYMQPGKRRLASHSKKRVAYFHDEGVGNYHYGERHPMKPHRLTLTNHLVLKYGLHEKMEIFQPRKATDNEIRNFHSADYVDFLKRVTPDNADQYENLFQRFNVGDDCPIFDGIYDFCQRYAGATIEASRKLIADGADICINWSGGLHHAKKSEASGFCYVNDIVLGTLELLRYFPRVLYIDIDIHHGDGVQEAFYSTDRVMTVSFHKYNGDFFPGTGHIDEIGSSLGKYYSVNVPLRDGIDDDAYVWLFKEVIDAVIGTYQPSAIVLQCGADSLGCDRLGCFNLSIRAHGRCVQLVKNFNIPLLVVGGGGYTVRNVARCWTYETSVLVDTELSENLPPNEYRDFFKPDYKLHPDLKGRVENQNDRTYLLKVRERVMEQLRYLDAAPSIQMQEIPPDIQGFLDGEEEQRDAEEDSEKGKDTRLYRGRRIIHDNEWYSDDDDNDSVGRWSDTMEDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWQ4</accession>
    <name>A0A367JWQ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000589">
        <property type="protein sequence ID" value="RCH94335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWQ4"/>
    <dbReference type="STRING" id="86630.A0A367JWQ4"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="41"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="19585" checksum="2EEFF23772381499" modified="2018-11-07" version="1">MALSNRFFADAFRDMHRAFSLLDDPNFFDDARRSLTSANNSLGSLSRYPATDINETAEGYELHAELPGYDKKDIHIDVADDRTLILSGSVRHHHHESSDEKQKQQEGKSTAVSKEVKSDGPKWWVNERVSGSFQRSFNFPSPIDSAGIKASYENGVLKVCVPKAANQGKKRIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX55</accession>
    <name>A0A367JX55_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000570">
        <property type="protein sequence ID" value="RCH94516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX55"/>
    <dbReference type="OrthoDB" id="5511466at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10571" checksum="5746AAC5649A7833" modified="2018-11-07" version="1">MSDNKRTVANPNYSRRSEPQDGFKSLQEFYPFYLGEHCNKINRRLHFLGTTLSLVFAYLAARHRKAKFLLAGILQGYFLAWIGHFVFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXG1</accession>
    <name>A0A367JXG1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA methyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRMT2A_4</name>
        <name evidence="8" type="ORF">CU097_009750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000557">
        <property type="protein sequence ID" value="RCH94623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXG1"/>
    <dbReference type="STRING" id="86630.A0A367JXG1"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="531" mass="60789" checksum="4730C95228985B5C" modified="2018-11-07" version="1">MHTTESSETFIHRVKVLNLPKHELASIKQFFKLHNLHKFKKAPMWEYAYLNFETAEEAKVALEKLNGKEFKKRLLSTEYAKVSEKQFRDRFKVNKTIEQEDTRTPAQRLADQVTPLHKLSYEEQVAKKRKAGVRHLRDLRKKLNALPDLSEEARAQISWTTSDNPDDACQILDPIQSPITHGYRTKCEFTIGKNIQGERTVGFLLGQYRDGVTAVLEPYDCLHVSDKAKEIVRAMERYVRNSEYDVYDKVAKTGVWRSIMTKTQETGDSMEKEITDELSDDQLEQEKEKIRAYWTQLKPEINTTTLMLQTWNGVSNGITDKGQTEILMGDGYVYEHLLGCRFRISSSAFFQVNTPATELLYSKCAEWCNISQDKKTTLLDLCCGTGTIGITMAKTVDRVIGIEMIPEAIVDARANAHMNNITNVQYYASKVEDKIDIVTNERNEQVVAVLDPPRAGVHPSVIRAVRESPQIKKVIYISCDAKQAMQNFIGLCRPTSNRAKGIPFRPVRAVSIDLFPHTEHCELMIEFIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXH6</accession>
    <name>A0A367JXH6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_007365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01000556">
        <property type="protein sequence ID" value="RCH94630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXH6"/>
    <dbReference type="STRING" id="86630.A0A367JXH6"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016569941" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="162"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="564" mass="63264" checksum="9345C80F77183B1A" modified="2018-11-07" version="1">MKLSIAAAAALLLSTVIDAKTLLFPIPQDVSWTGAQKSLSSNFKITGADNTYVQEASKRYIKLIHKESWVPVQVTPKEHLKQGDALQSLKIVVKDNKAKLDLGVDESYMLDVPAKGSQATLEAKTWVGALRGLETFSQLVQQGSSKGHLVAHTAHIKDAPSYPHRGVMLDTARNFYPVKDILRTIDAMAYNKMNVLHWHITDSQSWPIYIKKHPELSKKGAYTPDMVYSPKDVETIIKYGQSRGVRILPEIDMPAHTDSIALSHPELMACHGLWWGTYAAEPPAGQLNVIHPGTIKLVKDVIKEITSRFPDTLYHAGGDELNAKCWPTNKQMSDYVKKHKTTFEQVWYDFTNDIIDYVIKQKKRSIIWEDPVKDGGKIKTDTIIQSWVNPPSNYTSAGYDVIVSNYDYFYLDCGHGGWVGNDTRYISPTQTQTADDSFNYGGVGGSWCAPFKTWQRIYSYDMTYGVEKSHKGKVLGGEVALWSEQAGPTVVDSRLWPRSSAAAEIYWSGSYDKKGNRRTLGEVQPRFNDWVLRMIGRGIGAEPNTPRWCLLNPNRCNLNEPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ23</accession>
    <name>A0A367JZ23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000490">
        <property type="protein sequence ID" value="RCH95214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ23"/>
    <dbReference type="STRING" id="86630.A0A367JZ23"/>
    <dbReference type="OrthoDB" id="2239932at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="40278" checksum="D982D4056F075FD6" modified="2018-11-07" version="1">MQKSTEKTSFELLDAKMKRNLQDLLAVQKLLKSKSPKEEDRQIQQLQLECSKYQTEAMDYKTRLKEAHEQLISLQDRVTQLQKVEEHTKKHELEHASWKIKLDGLKKDNEELKEINQQLECDINTKSKEITQLESALVAVEKELKNAQERLTEKDKELEECHQRVDQAQDRLNKQDEKLKELLAERIIEKERLQKTIDRLKQENASFEQTMGTLRQENNSLEQRLNELEANNSKNIASVKTKSRIPVLTASLSSSTRNSNDIISDDMSQKMKKDILLYQEKLAELTAQNKELLTAFERSKEYSELLKAYLEESRHESDERYKEILRYREEINQLKRAQIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K018</accession>
    <name>A0A367K018_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epithelial cell transforming sequence 2 oncoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ECT2L_5</name>
        <name evidence="3" type="ORF">CU097_012807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000455">
        <property type="protein sequence ID" value="RCH95543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K018"/>
    <dbReference type="STRING" id="86630.A0A367K018"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="412"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="612" mass="70175" checksum="D16FB7485B8BB483" modified="2018-11-07" version="1">MVKKRNQHLQIDTHTPSTLSNVKEDTVLEDFDHGWNPLFSFTPINKETKRYSTSIIHSTVEQKQLDIKRSHHRSASADNELANSLPRVSSVPELNQTSIKPLTKNASQRKRWFQLPRMTLKRNPSTPVRRMDSGTRTAVIEPPEPPPRLLFNLQWSSEYMAASPLIWNSDDNSSNSISTPTSPTISRKSSKIEIEFSDCLLNSPDRVTISQQLDTAFMNRRLSCPVYDQIIETSQESVVKDDSTVYSHPKRLSLLSKAKTMIDSSTSNHVCNTTSARLFSMSYPRSLTQQRPRLKKTSDISNSNSSSSSSIHSLITSSTTSISSSSSGPATPDNECPLGSVLTPNASKCVINFGNIKPRSFKMKRRCNPKQELKALSLWQQELIKALEPDRYTLPKIDVDMISDKRERYSQTRKFILREFYTTEVNFWNQLNYAKVMFCDPLVDALERNIPLVKPADIDLFANLEDLMKFSLTLIYRLRKLELEQRSKNSSSSNVWPISDINVGSVLRDMAELMVVFLRCALDYRANRELIDKKHQHKVYAVYKEKLALRKETRQFTFEDYLIIPIQRITRYGLLLADLEKHTEISHPDYEDIRISRKIVQSLASTMNLVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K085</accession>
    <name>A0A367K085_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000454">
        <property type="protein sequence ID" value="RCH95555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K085"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="65"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="214"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="379" mass="42054" checksum="2B3926E9D7843CE2" modified="2018-11-07" version="1">MTSEGADPAVNPIPTSVTITNESTPLLSQEATTATSNSSFRQQQQQQSSVWSMSTDMSIRKREIKGVILLGASSVFFAIVSVFVKYLGNTIPSFEIVLARSAIQLFLGLIVCLFLGVNPLGKKGYRRWILLRALVSASALCLFFYSLTKLPLIDATVLFFVGPIFKTVVASVVLNEVYSFKDGFYSVICFIGLLFVIKPSIFFNVIIDTSRSVAVLCALTGALMSATAYVTVRKIGQETHVLVHIVYFGFVASMISLLVYLVRLQQFVIPDYHQFNNDLWMLGAIGPIAFLGQFLLSQGLKMAPTGLASVIQASDVVLAFIFGIALFKEYPGFSTIIGSMIVVLMTTWVNVNRWRIYMTKNAAIRRRRSKDRLQQQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0H3</accession>
    <name>A0A367K0H3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000436">
        <property type="protein sequence ID" value="RCH95742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0H3"/>
    <dbReference type="STRING" id="86630.A0A367K0H3"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016877225" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="17693" checksum="A5406250BDDA0E58" modified="2018-11-07" version="1">MKFAIVGLMALSLVSAQNVTSDAASSVVVATTTTITPTSTTTSNCAVQSVFDLCLSNQDDYIKRCQPQDYACLCTTNKQKLSCWVNCPNDSGKGTQEGIVQEICSMPGANVSVTPWSSSAAPTSTNIVASSSIPASSSIASATPTKAASGSSALDIGNTAFALIGAAIVYMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0H5</accession>
    <name>A0A367K0H5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L16B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL16B_4</name>
        <name evidence="5" type="ORF">CU097_011877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000471">
        <property type="protein sequence ID" value="RCH95401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0H5"/>
    <dbReference type="STRING" id="86630.A0A367K0H5"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="22613" checksum="5E2B7EDDF9FBD425" modified="2018-11-07" version="1">MSTFEKVVVIDGKGHLLGRLASIIAKQALNGQKVVVVRCEELNVSGEFFRNKLKYHAYLNKRCVVNPRRGPFHFRAPSRILYKAIRGMIPHKTSRGAAALDRIKLFEGVPAPYDRVKRMVVPDALRVLRLKPGRKYTTIGRISHEVGWKYQDVVAKLEEKRKAKSAAYYQRKVALAAIQKKAAEAKADAVKDVNAAIAALGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0K7</accession>
    <name>A0A367K0K7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000443">
        <property type="protein sequence ID" value="RCH95677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0K7"/>
    <dbReference type="STRING" id="86630.A0A367K0K7"/>
    <dbReference type="OrthoDB" id="2291937at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="165"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="344" mass="39731" checksum="840F35B66652A0EB" modified="2018-11-07" version="1">MYTQNTEKRHSAYNAYTWPPYDTYPRRVAESSSFNELGPATLPSGVLKESSHQTVPDSSGFFNYIAYPEMSDNSPASTSSDGQTPYLSDENTMESPPVMHHHPMNNRPYGAPSAFRSYNGNGSHMAIQRPPKIHRPPSRPSPSFHHLLNDDSAVSRIAYSFEFSQVADVTIGWDPVEVRNGRRLVEFKIERELMKPSPQKHAVRQITVTYMTYPTKYYCNLISHGEGSKRKEIFTPLIISCIHWPQHENYFVTSFDLITIFKKLLDKEFEKPIINRMRRHLECLKPITVYPDRIETRDFFDKVVSYTLPKSASISKEFKVYPWSEIQVALIKLASKLREQSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0K9</accession>
    <name>A0A367K0K9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000439">
        <property type="protein sequence ID" value="RCH95710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0K9"/>
    <dbReference type="STRING" id="86630.A0A367K0K9"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="406" mass="46424" checksum="0FA32621366BAA91" modified="2018-11-07" version="1">MDVMDEYKQFIHDSRPAHYTRRWVRKMRSYPDHLRIQGSVIPTITPLIILIAIYTYFIGVMYISWVPALSVVLGLLLAFRANTSYARYYEGRQLWQDLTSNVRNLARLIWVSIPERTQNDHLEKMRCMKLVLAFAIATKHYLRREYGIDYYDLDYLLPPNWVPATADDQLLDSDDNGGAHGGDDALVPDHHQDHHQEEHLMETNEGGDKRTDIDNRPISVTPTVAGSSNASNSSMKSGKRMKKKKFVSEEDLPDEGIADMSLPLEIIFRMSLYMQQAKTTGKVDDTFSNVIINHLNNLNDCLASMERIVNTPIPAVYVIHLKQSLALYLLAIPFTLISELKWWVVPTLILASFTLFGIDAIGAQIDNPFGYNNNDLPLNTFCDSLRKEIEFIVYHLPCEAENALMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K145</accession>
    <name>A0A367K145_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000415">
        <property type="protein sequence ID" value="RCH95962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K145"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="343" mass="39519" checksum="971CD389D3EB8D59" modified="2018-11-07" version="1">MSEKKRSLSFENEDSKRQRRFTLDVAADNQFLLEDYFSLAIVLLDPTKIFIFKDRKDEYIHTLAKHAVKLAHGNLLNTIERMLRLVDSNTSDQELNLLLAKVEDIDKEREYAFITCTIQCLKNKTSRVDDIIRSQLDSRSLLQQVLFHDVRFARLLPLFHVLFNHDSSMVTTSSYENGSSASYKSSSMIGTIANSQSTFSYSSSFDDFISRIPDTNYDEPHDMQEFSIISATMDSDGNIMDDTTTQKESRQEFSVAENEKTTLCYNELILDEIKIGENVLDDSVKANIIQHLKTNKPNVWEKIVNYEPVDIDECYEGLEYKKGLLRAFLDEFGCLNKNKIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1E1</accession>
    <name>A0A367K1E1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000409">
        <property type="protein sequence ID" value="RCH96024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1E1"/>
    <dbReference type="STRING" id="86630.A0A367K1E1"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="239"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37927" checksum="7CC514C99518E89D" modified="2018-11-07" version="1">MSTTVKPIPITVFTGFLGSGKTTQILNLLRKVPKDYKICLLKNEFGDIEVDSQLAKESNIGVQEMVNGCLCCVLVGQMKLALQELKEKYNPDRIIVETSGSAFPAPIAWQIREMESEGFTLDSIITVIDCENFNGYEDTSYTAKLQAQYTDVILLNKYELVDERRLDSVVDAVNVLNTDTPKVKCEKDGISPDLVFGLDTQLFKIGYSHAHTLESMVFDPHHQKNEVDLIQVTQNVTDKGLGKEELETFLKSMPKDDIYRIKGFIRLNDGQLVIINHAFGRYTMTPVENEETLENTKDVQVKVTVMGQDLRMYTERVKGLLNGQEGEVKLTQAHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3T6</accession>
    <name>A0A367K3T6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DPH5_2</name>
        <name evidence="11" type="ORF">CU097_014240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000335">
        <property type="protein sequence ID" value="RCH96809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3T6"/>
    <dbReference type="STRING" id="86630.A0A367K3T6"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH96809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="31757" checksum="0261716CC0740711" modified="2018-11-07" version="1">MLYVIGLGLSDETDITVKGLEAVKRSERVYLEAYTSILTVGKEKLEAYYDKEVIVADREMVESDSDTILANADKIDVSFLVVGDPYGATTHTDLVIRARELGIPVKVIHNASIMNAVGACGLQLYNFGQTISIVFFTETWRPDSFYDRIKENHQFGLHTLCLLDIKVKEQSIENMARGRLIYEPPRYMTVNQAVEQLLEIEEKRGEGVCKPDALAIGCARIGTETQKIVAGTLEELVDVDFGGPLHSLVLVGKRMHEMEAEFVKEYACNPETFDMIVKRDYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K489</accession>
    <name>A0A367K489_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000317">
        <property type="protein sequence ID" value="RCH96998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K489"/>
    <dbReference type="OrthoDB" id="2283974at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="23677" checksum="E868BB95D865D074" modified="2018-11-07" version="1">MTARFYANNIPSLRKDVACHRFTVDDKHNWTTDESGDELRLQKDRFIELAQAALEQAKREEEEKGLLQELLETLLEHTGAPMVADVILEQIHSQDVIEKLAEDHFIQQRRRSSYEDDLNTLKEPEQQFDLVHSNNKQTYINSNNSHHPHHHSNSNNNSNLDTILTISEYLWRLFRLLMLSSIVGLVYHFMCANPTQHPSLFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K581</accession>
    <name>A0A367K581_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000288">
        <property type="protein sequence ID" value="RCH97305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K581"/>
    <dbReference type="STRING" id="86630.A0A367K581"/>
    <dbReference type="OrthoDB" id="3014599at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="34922" checksum="E876E8B846778E73" modified="2018-11-07" version="1">MCFVASFVCWFDAVVMLSGSPSLYTIGRSDMKLFEPYHFGSLFARRIGYVIGLLSAVGIVIGYIGSYLVVQKMTPTDTYYWLGLEFAMCFLRLLIWSWNTKKDDLNVIKIRYKIDRSDEGVIRQIRDLPLSSSEQTDIINKLKAGGYFIQSEIADAYYQARCYIHDFCFRNFNDLRIYRDFTSCDIISKPRYYILWDNSVLNPQKILVVHGFIGSLTEIHTGRVSYVKIPSITYWTYYFTGSEFEPLTEEQVGVAMIGILKSEMDAIAPWISFVTSRKQFDPELEEDEQMYKDIELKPQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K593</accession>
    <name>A0A367K593_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Anamorsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CIAPIN1_2</name>
        <name evidence="13" type="ORF">CU097_010743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000278">
        <property type="protein sequence ID" value="RCH97432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K593"/>
    <dbReference type="STRING" id="86630.A0A367K593"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049011">
        <property type="entry name" value="Anamorsin_N_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20922">
        <property type="entry name" value="Anamorsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH97432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="34563" checksum="A20E6D2B4A689B0D" modified="2018-11-07" version="1">MTFNTGENVLFVAPSTVDQSSFVSTQKAAQDQVGTSGKAAFEAIERVAEAPLANASFNVIYSNTFTPSVSIHSPAILSRYLSTLAAGGRLVMQEVVLLTDLANTVCPITRKASDLESMLKLAGFVDVTVTKLEPVSDETLASYFRLWGTTKIEQGVSRLSGKFGLAHIEAKKPAYEVGQKVALNFKKNNNKKAVWASVAADDLEDEDALLDESDLVKPSIESLTKPFDCEMTNGKRKACKNCTCGLAQEMGQEPGVVTLDLMDTTEDEIVEVDPTPKKTGGCGSCALGDAFRCSTCPYLGMPAFNAGEKVTLGGMFAQDDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5H6</accession>
    <name>A0A367K5H6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000279">
        <property type="protein sequence ID" value="RCH97420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5H6"/>
    <dbReference type="STRING" id="86630.A0A367K5H6"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE THYMIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883:SF2">
        <property type="entry name" value="THYMIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="269" mass="29950" checksum="7918CC249A7306C8" modified="2018-11-07" version="1">MIKVLILGAGYGTRLQKDLAVNPDYSHLLGIPKALLPLGQKDALITYWVELFQKHGITSSSIYIVTNAQCYDAFITWAKYHDIPLDHVVSDGTSSNETRLGAVPDILFGINHFGLDQSDVLVVGGDTLFLHDFNLDKFFDKYKQMNSNYDACLVTTYLVTEEQVHKFGIVETDSQGIITSFLEKPSPLATQSRKACPCFYLINSKAIPLIQEFVDNCKASNAPKEEYDATGKCLAYLYPRFKLGTFPISGRIDVGGLSSYIKANTYFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6E5</accession>
    <name>A0A367K6E5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000252">
        <property type="protein sequence ID" value="RCH97747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6E5"/>
    <dbReference type="STRING" id="86630.A0A367K6E5"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016662128" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14972" checksum="25479724D135AA95" modified="2018-11-07" version="1">MRSLSIVILIATLCSLSSVSAAPSHNSIGNGRQSSRRIKRFWGLGTYYEVGSGSCGEYDNDSELVVALNRDQMANGPNPNTNPHCNHMVFISGDNGSTTARIVDTCPSCPSGTLDMSPSVFERVCGSLANGVCTIHWNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6J8</accession>
    <name>A0A367K6J8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myb-like, SWIRM and MPN domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000247">
        <property type="protein sequence ID" value="RCH97798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K6J8"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08067">
        <property type="entry name" value="MPN_2A_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="339"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="7">
        <location>
            <begin position="591"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1291" mass="146270" checksum="2F03C09D89ED9B0A" modified="2018-11-07" version="1">MKEPISKAQEEEMSSALIAQLLAEDALSQGHLDYYAEYSNDNQYEDMDDSYEDNSEDDFDPRKKGRVNNRKDVKRGRKRKIPSSSTTTSTTTNTVSESPKVENTNESTNDIKDDTEEKPANKKPRKPVPEGYNTGVYTELEEKNFIEGLELFGRDWTKLQAHVGTRDSNSIRSHAQKHFIKMFRDNIPLPAKVRETGEGYTLSGRPLDPNSAAARPYLKSMAVAKTDEEKTETGVEKQTKELTISDKKEKKERKPTPEKKVKSNTPSPSTSSSTKSVSDSTPYDATGRTSYSSAKLRKQRESINYGQITKDEDPLTMIKCEPFIGKPGSNTAGCQPFHITVQSNVLLAMDFHAHLMTTEIIGFLAGDWDKETMRITVREAYPCRSIETGRNDVNVEMDPTSAIETRQLIEERNLKVVGWYHSHPTFVPDPSLVDIENQRNYQVLCRDEQASSEPFVGAIVGPYDPNLPGSASVINWFHVSNTNSERPIPKRLIYELQENENISDEESERLFKLLEIYKDSPEKTILNEAWRQDTTESKLDKMIKSLGSRMPWVQKKLKESNEFTDVFLERVQQSLKACSSMVNLPDTIDRTPEYVKFIKDLKQFHDSKGTRLVAEPVLGGCRLDLYKIFRVVVAAGGFDEVTKNRGWKQVGNMFDLRSTCTNSAYILKGVYIRNLLGYEEEKVWNKTWNPPAELLGPHAHRASTLAGKAYRQTERKTRPKIKKPTTNTDTSAIINTIVNNHVTEKDRILFALQFGRESDVEWALNMIVQKSFECPEKIELNQTPLLLDIFTSMAETGLMHLATAYHAERLNSNILDIMSNDHGHHSNNRELGTVLKVLHILRNVSSVKEYTQMLAHNRSVNNVILQSLEIAIMMGHVEIGRHSIDILENIAPNIHLISKEDPFLVSLYKLVSSHDRYLVIGSIRTLSWLSVRPTNHACLINSPVLEPIVRLLMADDEELVGTVVEYTLQYAKMSSESRSEVLKICNHGIYAMLIALLLTKSKYFSARFVQQESNTLLPNATKSASNQGQSKVIPRVPDLTIYHNLDEPYRCLGWQVLKDKFEVAERTSVVSLDDIYLLYEARFGLEKALKMKDFYTVIKIAFTPALSPQSAHQTPYPSPTIEGLNVCGIQMKTSILQDRPQVACQWNGCLRLFTDTFTLQTHVLCHHMVSTEEEKEYYCQWASCQGYALTREAFISHLQSHFFTNDYSQCTSPELSSSPSTPSSSSSVETMDHVDSNESQGVALVVCHLLDLLSNDPEGAQHLKSFDKELNSVAESRPKLASRVWAIRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6T0</accession>
    <name>A0A367K6T0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000241">
        <property type="protein sequence ID" value="RCH97877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6T0"/>
    <dbReference type="OrthoDB" id="2340857at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017043297" evidence="1">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="30663" checksum="9324FE8F33BAB2D5" modified="2018-11-07" version="1">MKFSITAISALILSTAVSMTTADSYSDAMKSWCGGLGVSFPTSSTVVTAGSKTKVTVTRKPDQRTKTVTGLDLYSVDSSGKAKYVQNVWSGKYNLQKTASITDTIPSNVSPGLYYYRVWVTNMVNGQHGPDCLQTSHTFKVTSSSHKNADGTMEYAESLDDENIYHPDHYNGCFGLTVDYPAPNGEFNVDEHIHIQVNRDSASQTDALTKVELYKGDELVDVAWTGNEPILNSFTLKDHLKLDNVDPAADYHYKLEVTSQHSDDHCTFVSNNFKIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7Z3</accession>
    <name>A0A367K7Z3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PKA1_11</name>
        <name evidence="13" type="ORF">CU097_014478</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000207">
        <property type="protein sequence ID" value="RCH98308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7Z3"/>
    <dbReference type="STRING" id="86630.A0A367K7Z3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="83"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH98308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="392" mass="45281" checksum="EEBD44B03612659E" modified="2018-11-07" version="1">MSFLNKIIDKAKNHKNEESSSSNCNQKAALPKIPENHVAEADTSRPIITENASKFSFKNRHKQYDSAILDQRKNKPKLKLDDFSLLRTLGTGSFGRVHLSQSRHNSRYYAIKVLKKTEVVRLKQVEHTNNEKHILESVAHPFLVTLWGTFQDDANLYMVMDYVPGGELFSVLRKSKRFPDHVAKFYATEVTLALEYLHNKNIIYRDLKPENLLLDATGHIKITDFGFAKYVPDITWTLCGTPDYLAPEVIQSKGYGKAVDWWSLGVLIFEMLAGYPPFYDDDHLKLYEKIIQGKIRWPSYFDPNAKDLLKHLITADLSRRYGNLKNGADDIKNHPWFFGVDFARIASRQVRPPYVPQIRGDGDASHFDRYPETNEQYGTPCQDLYRDKFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K811</accession>
    <name>A0A367K811_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000207">
        <property type="protein sequence ID" value="RCH98307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K811"/>
    <dbReference type="STRING" id="86630.A0A367K811"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH98307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="556" mass="61782" checksum="65BB0F7F4500E1A9" modified="2018-11-07" version="1">MNTPKDQEASADEVNHTKLTTYPSSEVTGHLAADRYKYNAGKSGLAGFIKNPYVCLTAVFASIGGILFGYDQGVISGVQEMDDFIQRFPMNPTQTGFMVSILELGAWAGSWIIGYFADRIGRKHSITLSTVIFLLGSAIQGGAQNVNYLLGGRFVTGMAVGALSLLVPLYQSEISPPELRGSLVSLQQLAVTFGILISFWIDFGLTRVGGQASWRVPLCLQMFFAILLGLGILCFPFSPRWLMGQGREEEALRVISKLRRLPQDHPLVIEEWKEIKVSVEFDRQVEREQYPQYVDKGRKGRLMIGLMGYRDLFRKGIFNRLAIGSIIMFFQQFSGVNALIYYAPKIFQSVGLTGTSVSLLATGVVGIINFVMTFPTVFLLDIVGRKRTLMVASIVMAICMIIVAIITALFQHDWPNHTAEGWVSVAFIYIFIANFAYGWGPIAWVIAAEIFPLRARAKAMSVTTSANWMCNFIIGLIVPTMLANITYGTYIFFACFLVLSFFFVWLFVPETKGRSLEEMDEIFGGQSAVRDAEIMNQVQNRVNQSSIPVETKGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8N3</accession>
    <name>A0A367K8N3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000186">
        <property type="protein sequence ID" value="RCH98583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8N3"/>
    <dbReference type="OrthoDB" id="2229752at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="369" mass="41917" checksum="B1BD47474F6CB8E6" modified="2018-11-07" version="1">MIEDRIRLYQEKYKHFMEADTQLRTWINTNKQKGPPLALKEAFPCLRPRMSSISTPLSSSKRKSLLLHSNQEFDIVSPTPKASFSTFLKKAMRPSDSTQTKHHNKSSPHYLGRSDSRLPEAPKPRASASTSSKSHRFFLSSSFNRLSLLKQPAVPPHDPNVVRAKVDQTEPPCSDHQGTFSKRKQQGLPAILEYSKNNNSTTKTSKQITRKNIRPQSTIVPYSPSSVFLDRLQRDNLYEERECQMIQPNTYNKTTIYATVGKKGLRGHDNLAPSHCGFKDLDDKEDILNEPRSSKPHRMAFKSSTVGKASARNILDSRNKQDIADQHRSAMTEQSPQKKRISFSLAPSLSSLRFMSQKSSFLKRQSMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8Y6</accession>
    <name>A0A367K8Y6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000181">
        <property type="protein sequence ID" value="RCH98645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8Y6"/>
    <dbReference type="STRING" id="86630.A0A367K8Y6"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="119"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="270" mass="29873" checksum="B3DBD094BEC795F0" modified="2018-11-07" version="1">MGINQSQLTADGLWKKENAKKGLQIMGAAGSAVLLSPVVMLALPIVGAYEFSKALDDELITGHNIVDGLIGGLFGVVVSPLAPFYYFLTSIRTIFGYKRELINEEYLQRAEGMLRLNASYYNVAVVGSPGTGKSSLVNAMLGYQHHHPKAAAVGEAETTMEPKAYRHPLLPALALWDMPGIGTPRHPHKDYFENYCLGAFDALLVVFDDRFMATDVDLARKAARYNVPVFFIKNKADLSIERKIQRLKTRQLSDTEKWAQAVSDLVLEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8Z2</accession>
    <name>A0A367K8Z2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000182">
        <property type="protein sequence ID" value="RCH98630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8Z2"/>
    <dbReference type="STRING" id="86630.A0A367K8Z2"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="88"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="48043" checksum="378E16F58714C91A" modified="2018-11-07" version="1">MNDILTSARRLPQRVIIRILKRMFTLPAPAARLILNDIIKPKKIHKQWIYRVRRRENKGWFGCWIGDNLHKLDPVRLLKRVHEADVILFYVHGGSFRFGNSTMYMDTNISWLKMLKERHGLSAMIMLAPEHKFPGPIEDVVRAYEYLISEIEVKPEKIIIVGDSAGATLLLNMLLITHDPISFEMTKNHQALQRPAGIVLSSPCVTDKTSSESWKSNQKYDYITEYGMKVMKRDCFEDMQTTKYPILDITALQTEFSSFLSRKMLCFVGQLEVFRDDTLTFVNKLQQDNIDCQVVMEQCVHDWFCVREVVKNKSILRNADEIFADYCFQTIQRRVDNKRDIMDNDSHTIASISSISCIDSDYSSILHRYESSSFTEDDDDALVYSIINFRLSKTSLNEQDDRPSSQCSSDIVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9L2</accession>
    <name>A0A367K9L2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-1 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AP1M1_2</name>
        <name evidence="10" type="synonym">AP1M1_1</name>
        <name evidence="10" type="ORF">CU097_005041</name>
        <name evidence="9" type="ORF">CU097_005647</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000165">
        <property type="protein sequence ID" value="RCH98857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000121">
        <property type="protein sequence ID" value="RCH99466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9L2"/>
    <dbReference type="STRING" id="86630.A0A367K9L2"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="166"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH99466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="436" mass="49962" checksum="383B0C3D3595FD68" modified="2018-11-07" version="1">MASAIFILDLKGKVLISRNYRGDIPMSAVEKFMPLVSEAEDEQVPLPCFTHEGINYLYLKHSNLYLLALTRKNTNAASIMLYLHKLTEVFTEYFKELEEESIRDNFVIVYELLDEMMDFGYPQTTETKILQEYITQDAHKLEVQVRPPMAVTNAVSWRSEGIKYKKNEVFLDVIESVNLLVNANGNVLRSEVLGSVKMRCYLSGMPELRLGLNDKVMFEATGRGGSATKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGDFELMSYRLQTTVKPLIWVEAVVETYSGSRVEYLVKAKAQFKRKSTANNVEIEVPVPDDADTPKFKSSSGSVSYKPERSCLVWKIKQFQGGKEFIMRAHFGLPSVQAADESEKKPPINIKFEIPYFTVSGIQVRYLKIVEKSGYQALPWVRYITQNGDYQMRMPESIKANKRVSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9W4</accession>
    <name>A0A367K9W4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000183">
        <property type="protein sequence ID" value="RCH98621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9W4"/>
    <dbReference type="STRING" id="86630.A0A367K9W4"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="222"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH98621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="496" mass="55420" checksum="BBF27CB23102D5AC" modified="2018-11-07" version="1">MTLKLKPTLEQVQELVANDAGNTIPIYAELEADLLTPVSAYLKVADRCDYSFLFESVEGGENISRYSFIGSDPYKLIKVGANETCQGDPLIPIEKELSSIRYVKIPGLPSFTGGAVGYVGFDCFQYFEPSIKGDLADPLGIPDAIFMMCDTLVIFDRVRHVVNVVSHFRSDVKDPKEVEREYRKAAEEIETTLTLLHDDHIPSVAQGPITTLGQQAISNVGKEGYMGFVSSLKHHIKEGDIFQAVPSQRLARPTDLHPFNVYRHLRSLNPSPYMFYMNLKEFTLVGASPEMLTKVQDRIAFTHPIAGTRKRGKTPEEDKALAEDLLKDPKEIAEHVMLVDLGRNDINRICKPETVKVDKLMQIEYYSHVMHIVSNVSGELREDKTPFDAFRAIFPAGTVSGAPKIRAVELIRGLEKEKRGVYAGSVGHFDYSGGMDTCIAIRTMLFKDGVAYLQAGGGIVYDSVEEDEYQETMNKMGSNLATIEQCEQKIFEQQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA37</accession>
    <name>A0A367KA37_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000146">
        <property type="protein sequence ID" value="RCH99103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA37"/>
    <dbReference type="STRING" id="86630.A0A367KA37"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="86" mass="9191" checksum="346797F6F58314E6" modified="2018-11-07" version="1">MKTFVGPGAATCCSLLSFCGIIFLVLLGTAFKAKVEVLTEFTSDPDNPNATAEACFTAAIVYACFLGFCGCQALVHKYNSRQQIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBL7</accession>
    <name>A0A367KBL7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Alpha-amylase</fullName>
            <ecNumber evidence="4 17">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CU097_000386</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 17"/>
    <dbReference type="EMBL" id="PJQL01000111">
        <property type="protein sequence ID" value="RCH99605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBL7"/>
    <dbReference type="STRING" id="86630.A0A367KBL7"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629841" description="Alpha-amylase" evidence="19">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="20">
        <location>
            <begin position="40"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH99605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="367" mass="40950" checksum="502BAA00600FBA09" modified="2018-11-07" version="1" fragment="single">MRLLLSLLCPLLFTPLFANASPITIRSQNSNDWSSRVIYQLLTDRFAKTVDDQSPCSDLGNYCGGSFQGIINHLDYIAGMGFDAIWISPIPQNAQGGYHGYWATNFSAINSNFGSSNDLKKLVQAAHAKNMYVMLDVVANHVGTPSTPNDYNGYTFNQGSYYHSYCDINYNDQTSVEQCWLSGLPDLNTENDYVVNTLYSTVSNWISEYGFDGIRIDTVKHVRKDFWDGYVKAAGVFATGEVLHGSVSYVAPYQSHVPSLINYPLYYPIYDVFTKAATMTRLKSGYNDIQSGGFSNLNLLLNFIDNHDNPRLLSKADQSLVKNALTYSMLIQGIPVVYYGTEQSYKGGNDPNNREPLWTSGYSSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCS2</accession>
    <name>A0A367KCS2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000084">
        <property type="protein sequence ID" value="RCI00043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCS2"/>
    <dbReference type="STRING" id="86630.A0A367KCS2"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="184" mass="20805" checksum="FF427393FBBA7B61" modified="2018-11-07" version="1">MHIEIAQAVEFLGRLLQSKVDQDTINAFKEKLTELLKIRFQDHWDPQQPYKGNGYRAISNFNGQLDPILTLASAAVPIQPSCIHAHLPRDFVLWIDPFSVSYRVGDHGNIMTLFEDRSRGRITLKMNPVSPSHSPMLPYVQPRISTPIRISPPNSPDNNVLKIDTPPSSKKDNEEKSKDLVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF69</accession>
    <name>A0A367KF69_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000038">
        <property type="protein sequence ID" value="RCI00829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF69"/>
    <dbReference type="STRING" id="86630.A0A367KF69"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016486371" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="592" mass="67990" checksum="54EF077DBB9E0609" modified="2018-11-07" version="1">MFSWSRIVFTILTLALLKTSLADEHNHVYKEGEEVIVWMNTVGPLHNRQETYPYFQLPFCQGPHSVEHHHETLGEALLGMDLVNSGIPTQFKINEADKAYCKQELEPKDVDVLRYAVDNQYWYTMFIDDLPVSGVVGKDEEEEQATETDPHAKKLYVYTHKSFAFEYNGNQIISISLKHGNLVELKHGLSSLTFTYSVTWNPTDVLFENRFERLLEADFFEHKVHWLSIFSSFMMVLFLTGLVSVILLRTVKRDFTRYDREEGLADFDRDLGDEYGWKQVHGDVFRQPPRLMMMSALMGTGSQLVILSAVVILYTILGDLYAERATILTATIFLYAFTSFVAGYTSAKYYARYGGRDWIKTFVMTASLWPGAVSLICGLINTLAIYYSSSRAISFYALLSIIALWIFICFPLTLLGTIVGRNWGSQADFPCRVNPIPRPIPEKVWYAEPLVIVALGGILPFGSIFIEIYFIFTSFWTYKIYYVYGFMLLVFIILLIVSACVSIVSTYFLLNAEDHRWHWVSFMTCASTAGYIYLYSVYYFMTKTRMTGLFQTSFYFGYTAILSLGMFCMLGFVGHTAASKFVRKIYQNVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFU6</accession>
    <name>A0A367KFU6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000026">
        <property type="protein sequence ID" value="RCI01085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFU6"/>
    <dbReference type="STRING" id="86630.A0A367KFU6"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="173"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="322" mass="36610" checksum="5AEE035EC04EF096" modified="2018-11-07" version="1">MSTPILDNGQGVIDPDVYFQLNKPPASLPEFESKLTAFVEYHQRLDNKIVFITSGGTTVPLENQTVRYIDNFSNGTRGAISAEYFIEAGYAVVFMHRQHSFQPYNRHYTHSHTTFLDYLEPKEDGTIQVRQEYANKMHQVLSKYQTVLRENRMLLLEFVTLPEYLFKLQAGTKILARLQDKAMYYLAAAVSDFFIPSQKMSEHKIQSSEGALTLTLDQVPKFLKPLVSNWAAKGLIVSFKLETEASLLVPKARQALTRYGHQVVIGNMLTTRKQAVTLITKDGERAISLTDEELANGKEIESLIIPELVQIHQHWIQSGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGJ5</accession>
    <name>A0A367KGJ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000014">
        <property type="protein sequence ID" value="RCI01344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGJ5"/>
    <dbReference type="OrthoDB" id="5279943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="26387" checksum="59130AD8EE04D9B8" modified="2018-11-07" version="1">MESPSKRKGSVTFDLPPPQQEEELLSPCIHTIDIHAQSVPDTMLVALFDREREMKELVEHNKSFFLSLKSFLNDKWPRFENTLYVPRSQMSDIEWITRISKALMPVPPLLEKFKELVGYLGEDDSQGKYDEEEEEEEEEGQPKVELARIRDRLGRLSRESYPQFYINCEQAMSKNEYDSFIHTLFHTAEIDDATWEKKIREQLKPWQNILEQLEEIVAYEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGU4</accession>
    <name>A0A367KGU4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000009">
        <property type="protein sequence ID" value="RCI01445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGU4"/>
    <dbReference type="OrthoDB" id="2425129at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17414" checksum="67985F6172E9A7A5" modified="2018-11-07" version="1" fragment="single">HHYTSSNREIKDGESSFNHEIVWPAIDLAVKSAATPIAFRLEEILLDASDEDFKASGPYGIKDSNRFGRDHVKGSSGALTFLRKILKTGYLATEDTMHKLKIVFIHARGIKMYFWKLEIPSEDAQVLEHVISTKIRPVVMKQGRSWDLETLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGW0</accession>
    <name>A0A367KGW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PUS10_2</name>
        <name evidence="10" type="ORF">CU097_015927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGW0"/>
    <dbReference type="STRING" id="86630.A0A367KGW0"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="82"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="9">
        <location>
            <begin position="266"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI01399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="518" mass="59082" checksum="6B5FD0B13BBDC186" modified="2018-11-07" version="1">MSSAVRDFLKKVILFDEDNHNKTLSVLKTLLECMCCCRCCLRFLGCSNLKLYAFQEKDLLVIYKDLIETTLSTSLVTSDSLCVACLGSLQHAEEYIEESYKALIAESYQVDSIALSCTLPVSTLIRNHLLKIYLEDTGHKYVGLEEEGFIKDPKNIFKYLLGEYIERHNKFMVENDAGLRMTVVIEHENSSQEHMILAQLEKPLLKIKTIRQKRRRVTVGDSRQCIHYALKKLDTEEVRKLTSIPPGTVTERAKITSVVLMNAPTYVAGRYLKFSREYSQTPWNVRGAKLAENSVSDCLELIKKYHKADDAKFGSAGREDANVRMLGTGRPFYLELVNPRIPRLSDEEYKKLEDEINQSPVHKDAVQVRHLTCIDPKYLSIIKEGEEKKTKRYRALVWLSEPLTDELINKINESCSKECAIIQKTPIRVFQRRAAIDRPKTIYSASISRLNDKPEQAHFGVFEMHAQAGTYIKEFVHGDLGRTTPNLATIAGVHSADLLELDVMDVDLVWPPSQAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHL8</accession>
    <name>A0A367KHL8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_015949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHL8"/>
    <dbReference type="STRING" id="86630.A0A367KHL8"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="289"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="680"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="320"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="710" mass="81306" checksum="BDF2C7EB8EA14347" modified="2018-11-07" version="1">MVKNSENAVKKTTNKIITTADDSGTRRLDHETDTSSLKSDYVNEMHVADFMNALAYDPMSMDAEHISAWTDALPGRSVRQNVDKKLKRSKRRLKQQEAAKPNGISYSLLRYPLIYIIGCIMAVELVAYISLRQIVRIWENVVSWRGEKKRLRDKLRQSKSYKEWCEAADKLDRYMHKDEWKKTIPYAYYDYRLLQKVVKHLKTYREGDTVEDALKMMDVLYVCLKQNFAGIENEQLYSNTYLGTKVLIEEYVEEVTRCIEALARNPHVPLDEKRLAFKLYAKNYGRTAFCLSGGAGFGYYHLGVIRALLDRGLLPSIITGTSAGSLMGAIVCTRSNEELHEILNPQLAQRIRIVGDSWKTLIARYIKTGALFDPERWCREAMWYCNGSLTFKEAFEKTGRIFNVSVIPYDPHSPPKLLNYITAPDCVIWSAVLASCAIPGILPAVVLMQKKPNSEHLIPYNYGHKFKDGSLRTDIPTLALNTQFNVNYTIVSQVNPHVHLFFYANQGSPGRPVTHRQGRGWRGGFLASTIEQMLKLDLAKWMKVIRHLKLLPNIHDQDWSSVFLQKFDGSVTILPKTGLMDWFYTVADPGEQRLKKLMYMGQLRTWPKVSIISNRLRIETAIELGRKITKEQGRHDASDVDTEDENIFLSGRRASMPTTDEEQHRRRKFMAQFNDTIALKKGGEEGDRIGEKELLTDDHDSHSSHGDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMK7</accession>
    <name>A0A367IMK7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004831">
        <property type="protein sequence ID" value="RCH78905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMK7"/>
    <dbReference type="STRING" id="86630.A0A367IMK7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="110" mass="11755" checksum="8B3F77BD3D50C2B1" modified="2018-11-07" version="1" fragment="single">PNTPSPSHSISNQSLRGSIFGPVDPGDQVARSVRASESNAPPVRNIFTYQPPAERSSVMSYPNKLGSSFSLSHDEGVNSKQSVDQQRNNPQHPVGVAGKPTPRVTHNIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMW4</accession>
    <name>A0A367IMW4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004758">
        <property type="protein sequence ID" value="RCH79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMW4"/>
    <dbReference type="STRING" id="86630.A0A367IMW4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35073" checksum="FDA39B3AE10C97F0" modified="2018-11-07" version="1" fragment="single">FPDVVIEHLAYNLDPKDIDQLSYTSKTLYKIFHNNNLWKSKAVHDFGDLFEIYTIFSTAATGLSLDPALTKKFQHEPSDWRSYYLEKNQQSEQDDSALIDQADQEYASAQAHLKSFQENGDMSILALVASKMMWILDVFPAHGGCYYILGFILFVLNKLEEAMILLQMGRAVDPTFEPFDELEEEIERIVNGYKGEEELLTEDNQLSEALKQALLEIFNKFDKDQDGALNSKELDQFIFTTNGTHPPPAFLRQIGLRFGANAKGWLTREGFLAFYLEQTLDDPSETRNDLGVHGYDPQSLRQKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMX8</accession>
    <name>A0A367IMX8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004738">
        <property type="protein sequence ID" value="RCH79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMX8"/>
    <dbReference type="STRING" id="86630.A0A367IMX8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="50" mass="6155" checksum="975AE422F1F9B171" modified="2018-11-07" version="1" fragment="single">YGNNDYQYNRNNGTRDNYNRYNGRPDYNNDIRNYQRNQNNQPPSQQQPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN43</accession>
    <name>A0A367IN43_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004700">
        <property type="protein sequence ID" value="RCH79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN43"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="15873" checksum="6F5182747D6F2249" modified="2018-11-07" version="1" fragment="single">MGNLPSKGGEWIESTAALPKRMRSNSKQFNGDPSLIPSKLLPSNSKRYSKTSVVSPVRHQIVTLDNVTPLVSLPHAATIHPLSPRRSTGYFKHRGSHDSQSISSITSEEVEPNTPTFLFGHDELSSSLPKDSVFDHDVWVYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ING2</accession>
    <name>A0A367ING2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004627">
        <property type="protein sequence ID" value="RCH79230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ING2"/>
    <dbReference type="STRING" id="86630.A0A367ING2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH79230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="39398" checksum="2E11F602A3E48340" modified="2018-11-07" version="1" fragment="single">MPVIANPSELDRQTFDFVIVGAGCVLANRLSCRYRVLLLEAGTRTHDDLVESRVPLLNSRLKNTEVDWKLQSVSQPNADNRTIGIPLGKMLGGSSAFNACLWHRCSPSDYDAWHTNGWTYKDLKPYFCKAESFHPAHDVHGTSGPIHATDLEINPESLGHYFRRACQNTGLPDYDDLTDKPCQIGVTHVQSSIYQGERSSTGACYLPKDILERTNLTVAMGCHVTQILFNDDQADKVRFNHHDHDYVVHIGREVILSAGALFSPFLLLKSGIGPKDELARHGINVVVDLPGVGKNLQNHWRIPLVHETIKPEMSLHRDLFINTEATLKQALDQKTGAMTRIWPDAVAYMKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPG0</accession>
    <name>A0A367IPG0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004438">
        <property type="protein sequence ID" value="RCH79529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPG0"/>
    <dbReference type="OrthoDB" id="2215285at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685659" evidence="2">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9645" checksum="08D7DFFDF0496491" modified="2018-11-07" version="1">MVRVFLPLVAFISLALALPVEQLAQSTPTTDSSTPAPRPTNFQHPSYNTQGLPESIFPDYSDIELGHTDGLHDVVKHMEMQNNGHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPJ7</accession>
    <name>A0A367IPJ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004396">
        <property type="protein sequence ID" value="RCH79607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPJ7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="9498" checksum="110F4DC6BA79BE09" modified="2018-11-07" version="1" fragment="single">ALINTYAMDVLETKVFQHRLEYERILPTDQENAHDRVQPDYPAQILSHFELPSQLAISIMNLFFFIQISINVNDFLTKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPU0</accession>
    <name>A0A367IPU0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial thiamine pyrophosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_001880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004358">
        <property type="protein sequence ID" value="RCH79673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPU0"/>
    <dbReference type="STRING" id="86630.A0A367IPU0"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="255"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39001" checksum="8A8FF9FE4CE253DE" modified="2018-11-07" version="1" fragment="single">KEINFSEFVFLLTNHSIVDHIKSEHLGKIMDIVVTHTITSSEPSVLDRYKAMLTSDTMKHLISGAIAGALSRTVVSPMERMKILFQVQGPETAAYTGIWSTLSKIWKEEGFRGFMRGNGTNVIRMVPYSASQFAAYEQLKSILMEPGKTELDTPRRLVAGAFAGTVSVACTYPLDLVRTRLSIQSATFKHDVSTPKKLPGIFPTMRLIYQTEGGIRGLYRGLWPTTLGVAPYVALNFQCYEVLKEYLIPIGDHSQGNIRKLFCGALAGSIAQTIIYPLDVLRRRFQVSGMNTMDYQYKGTWHALKTMTQKEGIKSLYRGLLPNYLKVAPAMGVTFYSYELCKEIMHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR45</accession>
    <name>A0A367IR45_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_001459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004067">
        <property type="protein sequence ID" value="RCH80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR45"/>
    <dbReference type="STRING" id="86630.A0A367IR45"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="8"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="358" mass="41475" checksum="E2DACD31A400C77F" modified="2018-11-07" version="1" fragment="single">TWWSQKKRKERISIHSDGCASGTGRTTFVNTLCDSNVLTKKICDNPEDAHHEPGINIKPVSIELDEDGVRISLTIVDTPGFGDNIDNEKCFKEIVGYLERQYDDILAEESRIKRNPRFRDNRVHALLYFISPSGHALREIDIELMRRLSPRVNVIPVIGRADSLTPQELKDFKRRIMEDIEHYNIPIYNFPYDIEEDDEDTIEENSELRNLLPFAIIGSDEEIMVNGRPVRGRQYPWGAVEVDNPQHSDFARLKSALLSSHLQDLKEITHDFLYENYRTEKLSRTVQGDDDMSLNAEDMASQSVRLKEEQLRKDEEKLRDIELKVQREIQEKRAELLNKEEALRSLEAKLSQAQLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISZ8</accession>
    <name>A0A367ISZ8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003729">
        <property type="protein sequence ID" value="RCH80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISZ8"/>
    <dbReference type="STRING" id="86630.A0A367ISZ8"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="9455" checksum="A937ABFB5076C98D" modified="2018-11-07" version="1" fragment="single">MTLTMRPLEDYDISPVTGFLPSKPPLKRLTNEYFAPWENMMDNFNGLLLAGRLREKIQELPLLDANRLGSIEEYRRAFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITR7</accession>
    <name>A0A367ITR7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gti1/Pac2 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003595">
        <property type="protein sequence ID" value="RCH81073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITR7"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28234" checksum="D2E986186C0FC165" modified="2018-11-07" version="1">MPITETFHGFIETTTDTLLIFEACRQGILPKINRRLQERERGAVKSGTVFVFDEKESGIKRWTDGLVWSPSRILGNFLIYRELDGRELLDEKASNLSSMSNNRPYADEYKTSDRERALVGSLTDTYKFKKGGLIKKTLSIQVNGSSQHLISYYTKEDVLNGKLATPSSIPEIASVQISPDLFMQQNFRIPLSLEYPEPFNKRLSISSNDSSAASRRRSSVFYMESSYPYMDAYSGCMIIREDVCLQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU54</accession>
    <name>A0A367IU54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003529">
        <property type="protein sequence ID" value="RCH81220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU54"/>
    <dbReference type="STRING" id="86630.A0A367IU54"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="66"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="251" mass="29238" checksum="E96A7220FF1A0732" modified="2018-11-07" version="1">MEENFQLKESICDIDSIKGSIIQKKRVPVDLHVNLLNALQVIYASNQLLNSINDSISTKYDSNNKEHEDKLLQLWNKLMPNKSLQSRITKQWIDIGFQGNDPATDFRGMGIQGLDDLLFFAEHYPAHARSILEHANDPLQWYPFAIVGINITKFNYQLVESKKLQLYLFEYGTDERAFQEFYCYLFYKFDQFWMFTVMEFESRFNEFKFIVEKELMQQKFDNTSSTIAPGVITVLVAPVTGNTLSININDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUL1</accession>
    <name>A0A367IUL1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003461">
        <property type="protein sequence ID" value="RCH81383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUL1"/>
    <dbReference type="STRING" id="86630.A0A367IUL1"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="231" mass="25644" checksum="4DCEFFBF60D5BDDA" modified="2018-11-07" version="1" fragment="single">MTTKLDTLTVNFSSAPYQRAFTASTSPVVLFNILDHYLRRNEPETKVVGAILGARSTDGTEVEIRNAFALIYTTEENEISLDREHYRTMYELHQRVNPEEIILGWYTAGKDLTPSCTPVQSFFAEDTSPFQPIHITVDIDALFKSSDMGLSAYACAPVGFSSKPGDCLFLPVPCGVKYLDAERSGLDMLASAKSNDNRTASLISDMDHLEIAVTKLQEMLERISKYVDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUW7</accession>
    <name>A0A367IUW7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003421">
        <property type="protein sequence ID" value="RCH81467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUW7"/>
    <dbReference type="STRING" id="86630.A0A367IUW7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="453" mass="51312" checksum="04DD65E8ECDFCAAC" modified="2018-11-07" version="1">MGNAQSSGDNEVYPTIVPKKKPSTPYNFFDMQHTADLPSPTRLRKESTHTSSARSHTSNSNKSVKDTANYFEMAAVTHEPSLPSKASSPRGTTPASSIKKSYTQSSSQLYQLTPTSSRSSSSKTINTQTEKKKPPSNVSDHLMIDGRIYSKSHASKNFMLPCDDDEADRLMTMHYILKAMFQWNFISPIHESFSSGEKLKVLDIGCGPGTWIMEMATEYPNSDFYGIDECSLFPTSIKPANAHFQIHDILKGPLPFEDEMFDFVYMRSMMIYLLPEELATLLSEIHRVMKPGAYLEVVDTNYTIRRAGPLSNSIINTELKQKMNPVGHVNTVESNTHHPIFTFLMMTQDHTLSFLGHFVDITQEHVAIPIGNWTGQQLDKLHTQNVKSFLSTIHLKERRLTTQEINEIIDECGRYNSYLDYFACYAKKPSRQDNLEQNTIDSINEFVQGFVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV86</accession>
    <name>A0A367IV86_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U2 snRNP-associated SURP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">U2SURP_1</name>
        <name evidence="4" type="ORF">CU097_001953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003390">
        <property type="protein sequence ID" value="RCH81536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV86"/>
    <dbReference type="STRING" id="86630.A0A367IV86"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12223">
        <property type="entry name" value="RRM_SR140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035009">
        <property type="entry name" value="SR140_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="207"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="36856" checksum="C5B82CEE163E7CFF" modified="2018-11-07" version="1" fragment="single">MSEKRKRERSESVEEEELEAPPLKTIPASKLQAYSVGRQKKSAFEKRKEEIDLKKQQESLEAAKVYAEFVASFQEPVSYKLGTTSFVKAGTLNPATNTINNAPSSSPSPPPPPPKPMFKAMPFVKASESTSKLYSLDQYQSKEEDDEEDDDEDQLAKLKKSKSQKRNLDTFLEEIKKEQQVRNSAKSSETITTTDDSVFGDGDPLSTNLFVSNIHPSVTELGLCQEFGKYGPIASVKIMWPRTQDEKDKGRNNGFVCFMKRSDAAEAIKNLNGIELEGFKLRVGWGKAVALPAEPVFVLEKATTTTKTGLPFNAQIDPGQPGVVDTNIFIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVQ2</accession>
    <name>A0A367IVQ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003283">
        <property type="protein sequence ID" value="RCH81780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVQ2"/>
    <dbReference type="STRING" id="86630.A0A367IVQ2"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41185" checksum="6DA04F3CF53AD66A" modified="2018-11-07" version="1" fragment="single">MLVGNNKTAAGRTGKKVTYIEPNEVGSMNQLCDPIGQQWCHTPSTPSVNYASPFLAIWDQYTFSNTSARQMSSTSGYPLLTDPVPGNPSSFFTNFPHRPCVASTIRIPQQTKSQDIPAVAPDNHQRKKETWSTPILKTTTAEGSISSTSTSSTGLFPHSSTPVEPPVRYLSDSLSFMATKAAFVEESQVTGIKRDYQVIKAINIPWSISAADIKRILSQSEFIRIPPMTELPQCVHIMMDVKTGKTLGVAFIECKIEKGRDIKSVLYDLPKAMPVQGRHIRFNPSSYDELLSHLFSEWPGTFRQGLATLPPNGNDQQSAPFFIGQRDLQNLLNVCRNYKVYYNRKCAERPFEYLISIIMNIPWNQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX52</accession>
    <name>A0A367IX52_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase core subunit rpc10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPC10</name>
        <name evidence="6" type="ORF">CU097_006861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003112">
        <property type="protein sequence ID" value="RCH82189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX52"/>
    <dbReference type="STRING" id="86630.A0A367IX52"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH82189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="57" mass="6617" checksum="9665C14083A7F2EA" modified="2018-11-07" version="1" fragment="single">MEGYQGAPIRQPPAMTYLCADCGAENQLKPREPIRCQDCGHRIMYKKRTKRMVQFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXJ5</accession>
    <name>A0A367IXJ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003022">
        <property type="protein sequence ID" value="RCH82415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXJ5"/>
    <dbReference type="STRING" id="86630.A0A367IXJ5"/>
    <dbReference type="OrthoDB" id="2259563at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9476" checksum="9247C566815FBD3A" modified="2018-11-07" version="1">MSNKPLNDILHRSSTIPVQPSFHSLDIQIPEPPQTEAGRWTFHSQKEFPPPPKFEKRLKRYPSGAETGCSIPIDLSHLINNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZN5</accession>
    <name>A0A367IZN5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002756">
        <property type="protein sequence ID" value="RCH83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZN5"/>
    <dbReference type="OrthoDB" id="2291008at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="12756" checksum="11FD73325E3EB408" modified="2018-11-07" version="1">MHLNQNHKHHSSITSISSSISSIDHHSNSSSHTSLTYKRYSELAPTRRWDDSQLEMELAEDDLIEEQRKKKFINSSLRLKLSENLKFRHSHSNSNNTPLFKRLYSWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J030</accession>
    <name>A0A367J030_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KRE2_2</name>
        <name evidence="4" type="ORF">CU097_004211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002785">
        <property type="protein sequence ID" value="RCH83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J030"/>
    <dbReference type="STRING" id="86630.A0A367J030"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="420" mass="49640" checksum="F4A9722B30061477" modified="2018-11-07" version="1">MYIQMKRGYTYIITLLLFCSLYFGSLYFVSKTSNSTVPYVNSILEDKSELTSNDVQITLSDNPGCPNSSDNTTLIQPTFNTTEQVKREKAVIVILVRNNELRPMRRTLREFEDRFNRKYNYPYVFLNDEPFTDEFKQSISALTNAEIKFGLVPKEMWSVPNHVNETVMYNSLYDYASRNIMYGGSLSYRHMCRFNSGFFYKHPLLQQYDYYWRVEPGVHFYCDLDYDPFTFMRENGKEYGFTITLKEIPETIPTLWDHTIKFAHQHELNTTLLRFFGSPDDGYNLCHFWSNFEIASLNLWRDQKYEDYFNYLDSTGNFFYERWGDAIVHSLAAGLYLNKSQVHFFNDIGYKHDNFAHCVDDGVLGKCMCPEDVGNFDEMWGSCLSEWKSYRTEGHQWNFKANGNQVLEDRIIHNQKYTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J064</accession>
    <name>A0A367J064_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SMD1</name>
        <name evidence="10" type="ORF">CU097_006920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002739">
        <property type="protein sequence ID" value="RCH83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J064"/>
    <dbReference type="STRING" id="86630.A0A367J064"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="116" mass="12757" checksum="1C41775F6B917DF4" modified="2018-11-07" version="1">MKLVRFLMKLNNETVSVEMKNGTVVHGTITGVDMSMNTHLKTVKMTIKNRDPISLDSLSIRGNTIRCVILPDSLPLDTLLIDDAPKSKKKKEGEAGRGRGRGTTRGRGGVRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1P9</accession>
    <name>A0A367J1P9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein mago nashi 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MAGO2</name>
        <name evidence="4" type="ORF">CU097_001648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002535">
        <property type="protein sequence ID" value="RCH83855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1P9"/>
    <dbReference type="STRING" id="86630.A0A367J1P9"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="11153" checksum="18AC226E03977AF7" modified="2018-11-07" version="1" fragment="single">YVSTAVLDELRKMIKDSDILKEDDSQWPEKNVVGSQELEVRLGNEHISFETAKISSLVEVNDSKDPEGLRAFYYLVQDLKAFVFSLISLHFKIKPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J340</accession>
    <name>A0A367J340_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002389">
        <property type="protein sequence ID" value="RCH84345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J340"/>
    <dbReference type="STRING" id="86630.A0A367J340"/>
    <dbReference type="OrthoDB" id="10440545at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="251" mass="28414" checksum="1BD1E1BE703B812C" modified="2018-11-07" version="1" fragment="single">MLRLNSIHGVDCVWHGVWWVVVSVFHSKILFNHILASLLFNWRRCEKRLLEVHNQSLRLHHIKVANPQENSATNPPWSSNNQQPWRSYPQPIAHSQQYAAYYQQYATPNGYYPHYYQHSNTPPPPGTTTEAPPGVGANNYGYYGYYYPPTSNATTAPPGMQQQHPSAYYSQYNQYQYNQPPGTYSYSQPPRPPPPTTNSETNVNTATSSALTPGRPFQKIPPWSKQPVGAVAATTNLQTSVQQQAITKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3M7</accession>
    <name>A0A367J3M7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002342">
        <property type="protein sequence ID" value="RCH84525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3M7"/>
    <dbReference type="STRING" id="86630.A0A367J3M7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="118" mass="13953" checksum="98C4FB589138C1EA" modified="2018-11-07" version="1" fragment="single">MHNYDKLLENDSISLHGGSSSTSEYQEPVPQAALSDRVFRLRNHLTKKQIRQFIYKWRWTLFFIINTIVSIILMLTFRRQFFQALETFSHKLREMGYGGYILISLLIIMSAFPPIFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3Q0</accession>
    <name>A0A367J3Q0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-canonical E2 ubiquitin-conjugating enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002334">
        <property type="protein sequence ID" value="RCH84560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3Q0"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15814" checksum="D17A5711E4202ACD" modified="2018-11-07" version="1" fragment="single">MCICSRRLHTAKKLTVHHRVDQSDSSHDVVNVNTNTKQEQKEEDINMKQALMEMDGTVINSSGPTFGDYMTNRSKNIPLRLDLEERQLLKLLDAALNVSEYTDKVDIISYSNKSKRIVGQIRDLCAIISGLFVAGNYKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J541</accession>
    <name>A0A367J541_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CCT1_1</name>
        <name evidence="12" type="ORF">CU097_005790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01002198">
        <property type="protein sequence ID" value="RCH85043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J541"/>
    <dbReference type="STRING" id="86630.A0A367J541"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="11">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH85043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="32272" checksum="0A907E45BAEA8C1B" modified="2018-11-07" version="1">MPVQTISKTPEDTFHSFPYLTDDSPLVPSGLIVSGYDFKIKEPPTDRPVRIYCDGIYDLFHFGHAKALEQAKKAFPDVYLMVGVCNDAETHKRKGKTVMNEKERYESVAHCKWVDQVIPDAPWIVTQEFLDKYQIDYVAHDADPYQSTESDDVYAFVKAQGRFLPTQRTGGISTSDLITRIVRDYDAYLRRNLERGVSAKELNISFLKEKEIKTKKHLDDLKRQFKTAVLEQLGTWEDQSHELIRTFAGKFGAKDVVEKFLNKRRLLPSRKRPRSDSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5X6</accession>
    <name>A0A367J5X6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002176">
        <property type="protein sequence ID" value="RCH85131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5X6"/>
    <dbReference type="OrthoDB" id="2275138at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="698" mass="79961" checksum="0845B26F725557F3" modified="2018-11-07" version="1" fragment="single">MSSGYAVLNTRQSENTPDVNRFQELSHQISWCETDDVFLATWNNMPIWCRYCRKEDHTKFECVPNLKLELSVTVVIRMTTRSFECSPRNCPLNPHKKRNRKSHQLKQPVPLDLSTVNTQVQDSDEDSDDSDYREEYSETMLATSDKEGDDLIDEDEVRLLTEGISLVSDVWNIYHTLQDYTVFSSAGRLSSVTIDKRQTYTSVFFATIMETLHQKCIVINIPCEEKKAWFSAYHELETSSTWKIQFYSKSSAHAEEEPDIDGIVTPEHLRQEVLESKKRRKLTHYYNDAAVVALKSNLSDQVPLWLNGLCVLSAYELFSGGVSSYPFIAENYSMSSDEAHQAVNTIAPIFLESAIILQDDWFMVTSINAFIHYNPSIDDCADFSHIMYQSIANAYIRRKRRFNNKFFKLSIRYGPLEFFATAGFHELCNITETVPFLSISIPDLPTGLVAQVNMPSSTNIYFGSALLVHPLDEAISLGLSKLKELKFIIIPEDWTIIPLLERLVSWLAMSITNTSFNFLGNELLRTSLESENLYRSWDFVNTICFYSKIEAISNVSDYCAGKFKTVTVKDECVNSVYKVMYSTTEAEYNDGLVTFQAATENINNYVDVSRGCTSTQRAESSHHALKKDVSAVLPLKGAFRNVNEFINNFERKYHQLEIEEATRVDILLYEDSQLQKLFKKVSHRALSKAKFLALYALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J658</accession>
    <name>A0A367J658_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">APS2_1</name>
        <name evidence="14" type="ORF">CU097_002257</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002152">
        <property type="protein sequence ID" value="RCH85221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J658"/>
    <dbReference type="STRING" id="86630.A0A367J658"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH85221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="20176" checksum="F7E3A1D8B6C64B0A" modified="2018-11-07" version="1">MAIGLSGLATILFGANEDWLAVDDSNTFWKIRFILVQNRQGKTRLAKWYVPYEDEEKMKLKGEVHRLVAPRDQKHQSNFVEYRNYKIVYRRYAGLFFCICVDANDNELAYLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKNIVLTRLDHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J663</accession>
    <name>A0A367J663_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_000031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002098">
        <property type="protein sequence ID" value="RCH85437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J663"/>
    <dbReference type="STRING" id="86630.A0A367J663"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH85437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="289" mass="32190" checksum="467B3DB18A4E1D6B" modified="2018-11-07" version="1">MTSNVDKSQLSEEENVTRNDEQPLTSRAELWSYYLYYNGNNGYTIYSYMPVILQYLAYRGGFNPETNGPCDIQDALKPCNVHWLSSSVPVSSMLLYVQAIAFSIQLLLFTTFGSLADYGRWNRYILFTATVISCLFQALPIVLINDDGSHWPLMMAVMIIGLIAYGTTLVFYAAVFPILSDNLPAVREKGEDPEKWRNHVSTISTTWSNVGFVIVSGILAGVSFVQYNGGDLGDAPMYNFIGTVFCAGFLALNAIPYFITMPKGRKGPPLPPNSHYLTLGWTSIFEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J790</accession>
    <name>A0A367J790_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002017">
        <property type="protein sequence ID" value="RCH85776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J790"/>
    <dbReference type="STRING" id="86630.A0A367J790"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7875" checksum="43ED6FA263A5CBAE" modified="2018-11-07" version="1">MFRALNRFAIERPVIFWSCVLGGIGPVMVLTVPKIRREYFGFKGYEPLPVTYPLPNRSRNPPSGYEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7D6</accession>
    <name>A0A367J7D6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002007">
        <property type="protein sequence ID" value="RCH85820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7D6"/>
    <dbReference type="OrthoDB" id="2289242at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="35625" checksum="6E5C7135EFD5A817" modified="2018-11-07" version="1">MEKSQSSFYLWSPPPLDLSLDSFSADILNQFEKKSHSININEKDRDWEIYRRHSNTTADSGSDSSEQATPRLQESQNNYYSCDSPIQFPSTIERAISPSVINDGETSPTTNVFRKSSTFLKNKLSICSNIRSSIEITPDSRKSSITAGAEKLTRQYPPKPLEYSAVIEPPSENFDSIPSGSLASSKSNESIESDEEEEKDEGEEEEEEEEEEEEEEEETANVLIPASAISEYVNTEVDIDSNNDTVPQATKESSKDSSRDSNTRIENDVPSHKVNNQDIIATSSIEPMKSTGHSEKTKRSIPASPASKRRGFFFFRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7I7</accession>
    <name>A0A367J7I7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_002308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01001980">
        <property type="protein sequence ID" value="RCH85932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7I7"/>
    <dbReference type="STRING" id="86630.A0A367J7I7"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH85932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="36119" checksum="EE4995FFEC85365F" modified="2018-11-07" version="1">MVECNSVAALAAVGAIFLGYKVFTLFKTLFDVFVVPGISLKKFGAGQGYWAVITGATDGIGKEFALQLAKNKFNVLLISRTTSKLEGVAQEIADKYGVETKIFAMDFGKGNPEDFNKVSEIINSIPVGVLVNNVGTNHDIPTPFVEEDENVINSIIEVNIKGLMKMTKIVLPQMKQNRKGLILNMGSFAGLVPSPWLSVYSASKAFLLAWSQALGMEVAKDGITVEHLNTYFVVSAMSKIKRASLLIPTSKDYVISALAKIGVPCGANTPFTSTPYATHGLANWAINNLFSRKFWITQNYNIQKDIRKRALRKREREAAAAAAAAAEKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7L2</accession>
    <name>A0A367J7L2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002007">
        <property type="protein sequence ID" value="RCH85819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7L2"/>
    <dbReference type="OrthoDB" id="2264488at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="13981" checksum="7B8C6625AC191399" modified="2018-11-07" version="1">MAPALRFPDFCRSFEIHTDGVCSAGIGIILCQRDPHNRRAYAVAYASRSLSPIERNYGTKFTAVTDYHALQFLQSSRSSDLRGRLARSVLVRSVTTADLVASQASNSFCQNLRKSTPLTQGLADKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8D6</accession>
    <name>A0A367J8D6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001964">
        <property type="protein sequence ID" value="RCH86001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8D6"/>
    <dbReference type="STRING" id="86630.A0A367J8D6"/>
    <dbReference type="OrthoDB" id="2277655at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="129" mass="14416" checksum="CFDAFD6D9A4F2348" modified="2018-11-07" version="1" fragment="single">RGDISDFVKLGIEMRDMLDEILSIGVDDASVFGILIEGKQVSTYAMNTKSGVFRMIQLGEYNAIEKLSELGHFPALFTGLMQVKNIALNTARAIEKTERENSRGKKRERVDRRKSAGSIPTLKKLRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8J3</accession>
    <name>A0A367J8J3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001951">
        <property type="protein sequence ID" value="RCH86051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8J3"/>
    <dbReference type="STRING" id="86630.A0A367J8J3"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="123" mass="14754" checksum="BBC62CBE1FBCDCC2" modified="2018-11-07" version="1" fragment="single">IQVLHLQEEINETQGKIRKVRDMIKLYKQLLQEMTVRFSNTSKSDEPMRPPRTKEEEYDLLKKQIQDARLQSRLEQRLIITGWFDLVRRNHRDASSLAIRSAPSSWLGRQRKILDIQLRQRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8R7</accession>
    <name>A0A367J8R7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Luc7-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LUC7L3_1</name>
        <name evidence="4" type="ORF">CU097_008489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001897">
        <property type="protein sequence ID" value="RCH86306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8R7"/>
    <dbReference type="STRING" id="86630.A0A367J8R7"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="38160" checksum="BB8C5A30CF87A26A" modified="2018-11-07" version="1">MEYQKAMLEELMSQYVDVDNKDFWDDSVCKHYLVAFCPSQLFTNTKSDLGACDKIHNDRLKDKYQKSPDKSKYPYENEFYDYLNKLISDLGRKIRQGNGRLNIQSDDKAAEIRKEEREEKMVLLDVKIKELLQKVEEAGEEGRVQEATDLQAQVDKLQAELELVKQNKDGLNPTEKRMEVCDVCGAFLVTNDSSDRLEAHYRGKQHQGYLKIRDTIEQMKQNRQQRSHNNSNNNNYSRQRYDYHDRRDGGRHRDYRRYSDRERRDRYHHGRERRDHDDFAGAIESYSRRSRRDQDDYRSRSPVKRSRSRSPTRKYRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAQ7</accession>
    <name>A0A367JAQ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ganglioside induced differentiation associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GDAP1L1_2</name>
        <name evidence="3" type="ORF">CU097_009900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001768">
        <property type="protein sequence ID" value="RCH86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAQ7"/>
    <dbReference type="STRING" id="86630.A0A367JAQ7"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044617">
        <property type="entry name" value="TCHQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374:SF2">
        <property type="entry name" value="TCHQD CLASS GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="261" mass="30184" checksum="D8ADBDDC21C332D3" modified="2018-11-07" version="1">MSPKLTLYTFKLSLWAAAPRVAIHELNIPNVKQIEVDLSKAENFAPSYLKINPKHTVPTLEVEEENGEKQYYDDTTSIIKYLDSLTGNTLSISQKKTEIDAFLKEMHEKADVGNPLFFTSGSKEELGAKKDIIVPFLQGRIDAWEYYKKEAPEYTDLYDRHINETKGLLSYYTGGNPENMFALNKQLWQSATEFLNKAETLLKSNGDYLFGQYSIADIHFTPYLFRSNLVRKPEQVFENRPFLKAYYERIKARPSFSKTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAT5</accession>
    <name>A0A367JAT5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001784">
        <property type="protein sequence ID" value="RCH86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAT5"/>
    <dbReference type="STRING" id="86630.A0A367JAT5"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="560" mass="62741" checksum="D7BEA52CB5725DDB" modified="2018-11-07" version="1" fragment="single">MYWLNGIANQLSLDSTITKDSNEAYSSKVQRVLSLQPSNNATLFISCTRTSIYLWSVKVRQLYVAKCALLSYVERSLNHIDEFGENVKVIWKPDMTHVAIQTSKNYLLLYSILSYEQQSFELNFPNPTHAVMAGPGEGKGPKTMLLKFRLTIRVDAGIICGTSLDDTLVIATCSPPAIQCISWNPQQANATQSSLLSKIDFFDSNDQLSYITYEKSLNIFVWLSANGKVYFAQRKNNHSQKKGTTAVSEHKTQWVGTCFHGKEDILAEDKATSVSINSTFSLIAVGTAGGTVFVYSVENYNAPPVFSHKLQLMSWKSSTGSVASLAWTSDGHALSVGYESHGLAVWSVYGSMLCATNELDEIANEENLKDTYIKGIQYLFWGPGNYSLYVLAKYKADENIMYTLPFVKSALASYLHSDNAKKGLLQMDDRMLIYNSSGDYQDESTTIDPAAVAWTHIQYPAMYIADNWPIRYSSISSDGSYIAIAGKRGFAHYNTISSRWKLFGNQQQEQSFLVRGGMVWYKTILIVSCENVQQKTCEIRLYSRDNNLDHSQVLYTEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBI8</accession>
    <name>A0A367JBI8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001681">
        <property type="protein sequence ID" value="RCH87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBI8"/>
    <dbReference type="STRING" id="86630.A0A367JBI8"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019023">
        <property type="entry name" value="Lamin-B_rcpt_of_tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09465">
        <property type="entry name" value="LBR_tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="26318" checksum="3118C4645D2964B6" modified="2018-11-07" version="1">MPYINLMSSTEEIESYKFQLEQVELALASDPNNEELQKLQHDLKELISLFEAQLQKTPEHPKQKTPTTPTTPPTTALKTHEFSIGQEVMARWAGDGQFYKATITAIGGADQVFSVRFKGYKETEFVNSEDIKPIITKKRVGIFEDIKEDKKKKVQDPKPKVSKKKEASEIESKKNAWLNFATVGSKKKHSAINKKSIFKSPDTPDGKVGVVNSGKGMTSYQQRGKHVYAVADEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBK7</accession>
    <name>A0A367JBK7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_010617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001726">
        <property type="protein sequence ID" value="RCH87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBK7"/>
    <dbReference type="STRING" id="86630.A0A367JBK7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000044">
        <property type="entry name" value="Peroxisomal isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="18162" checksum="E1F0E66CE27673D1" modified="2018-11-07" version="1" fragment="single">MPSKIVVKNPVVDLDGDEMTRIIWQLIKDKLILPYLDLDIKYFDLSIQNRDATDDQVTVDAAEAIKKYNVGIKCATITPDEARVEEFNLKKMWKSPNGTIRNILNGTVFREPIVVKTIPKLVPGWTNPIIIGRHAHGDQYRATDFVTPGPGKFEVVFTPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD95</accession>
    <name>A0A367JD95_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001578">
        <property type="protein sequence ID" value="RCH87855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD95"/>
    <dbReference type="STRING" id="86630.A0A367JD95"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016677674" description="Sequence orphan" evidence="1">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43698" checksum="AAD489E7194C8C8A" modified="2018-11-07" version="1">MIFILILLHVAAVTCTKSLCLDQTDPLSINSRQWIECPFVSHQNEKRSSQSAPFTVTFHCFDLAPDDCIKAERAFKKAGDMLSSYIVFNEPVRVNATLVSFCKQLTQCDDNSTLGGSLPLRSMPLMNRDGVVRLHPQALVKQLQLRHHPAYAPFDIQSLFNADAPFWFDEDDVPIAGHQADFTFVILHELIHGLGFYSGWSDYLVPDALTPSIGALSTDMNLQFMESAMDRLLYILQDATPASTISQNLDAMMITDELLKTPASDMYRLATTPHTLGLIMANHTLVLETGLTPFRSGSSLSHVAQDIYKNTPDFLMRFSQERGVSLSDAMTRVGTASPLGPATLAVLDELGYTIIDQTQINMNYKHTSQGERNSLVWLIFLVTAAFSFHFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JER7</accession>
    <name>A0A367JER7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001469">
        <property type="protein sequence ID" value="RCH88426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JER7"/>
    <dbReference type="STRING" id="86630.A0A367JER7"/>
    <dbReference type="OrthoDB" id="2280553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15535" checksum="43A47495518213E2" modified="2018-11-07" version="1">MALTLARKDLPKYQITTSMNKPFPKEDSYDSEEHFLHTFERIVYSAGLDIEYVWDRYLPLCIHYDHGMWIEADLKRCSSWLDARKCFTKKFETKHRARKTTILVFIMEMRGTESIPQYIARFVKTINDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF03</accession>
    <name>A0A367JF03_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001464">
        <property type="protein sequence ID" value="RCH88455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF03"/>
    <dbReference type="STRING" id="86630.A0A367JF03"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="170" mass="19467" checksum="4343D163A9EBBE96" modified="2018-11-07" version="1">MEDHSGHGGHQMPSGPTCKMNMLFNWQVEDTCVVFQWWHISGPWSLLISCIAIFIIAAFYEWIRAYAAALESNWQQSALFQRNGNSQSNEEEQEQENVVYAYQQYTRLSNKRELARSAIYAILVGISFWLMLVFMTYNGYLMIATVLGAGFGHYFFGNGKLGVNKSIQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGI7</accession>
    <name>A0A367JGI7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001364">
        <property type="protein sequence ID" value="RCH89006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGI7"/>
    <dbReference type="STRING" id="86630.A0A367JGI7"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="366" mass="40941" checksum="A8AA2766B5798A6B" modified="2018-11-07" version="1">MTIQSLFSPIKVGRHVLQHRVVLAPLTRTRATLEAVPNDLLVEYYKQRASNGGLLITEATFIDRLAGGYIQVPGIYNKEQIEGWKKVTDAVHEKGAVIYLQLWHIGRAGSRKLNPNGEQPVSASDIPIKGVNYFGGGGEYDVPHALTVPEIKEWVQKYRQAALNAIEAGFDGVEIHGANGYLIDQFINSNSNKRTDEYGGSIENRARFALEVVDAVADAIGDDRTAIRFSPGGSFQDMGDDTVVETWSYLTSQLQKNHPNLAYLHFIQARANIQGDDDTLIEDTLEPYRKIWKGPFIASSGYSTAPEKAIDYAQKHGSLISFGRAFIANPDLPERLRNNWPLNKYDRSTFYTHDPEGYIDYPFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGY8</accession>
    <name>A0A367JGY8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001330">
        <property type="protein sequence ID" value="RCH89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGY8"/>
    <dbReference type="STRING" id="86630.A0A367JGY8"/>
    <dbReference type="OrthoDB" id="2283214at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="200" mass="22446" checksum="5D409EDBC4107404" modified="2018-11-07" version="1">MDASIDDQMMNVWLLRKIGLAPFSLSVRDAHNCLIEYNGMSHRRNVQGQSGGSFQCRAIVPTKYMTDSIDDHVLADTTLATMVHRSPYRIMLMRNKHHELDSSMTTLLNQDWDIHPEIKYVCAQSLAGAILLSSNGVAILISTIEIYGRTKTIDIHQEMNSGESSIPPDDAPYLDVYHTKLYTHEGAPSWSLACKHAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH58</accession>
    <name>A0A367JH58_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001317">
        <property type="protein sequence ID" value="RCH89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH58"/>
    <dbReference type="OrthoDB" id="2242533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="249" mass="28439" checksum="D09FF8F78A3A7632" modified="2018-11-07" version="1">MSQEHKEDLYGDSLNIKASKIDVRVVFKNDEKEIDVVCGELARNDVDSKIITDQGKLIRESNDAVDSMLSLVEKSAQAFSMQISGSACLIATQQLIRNGFYVYHPAYSFSLPSFVEELESFESTIQKLISFQQYVITIANILKKAGTKKYSLNQSFGKYDEVDKGDEASSILNWRRDTFYTSPRNNELKIPSFLFGVPSNDLISRLLKTKYFDGEEGVVYDQFGWGKKNDKWHNKIINKTQDECPYSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIL4</accession>
    <name>A0A367JIL4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001230">
        <property type="protein sequence ID" value="RCH89770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIL4"/>
    <dbReference type="STRING" id="86630.A0A367JIL4"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="308" mass="33977" checksum="4FE1E1C35EDE6A42" modified="2018-11-07" version="1">MSRLSRIPYFLSYFLGYRKPDHKQKILPLWRICFWSFLAAWVGIAVLEIIFVYAPSFQAHHTPMIIASFGASAVLIYGAIDAPLAQPRNVIGGQIIGSIVGVVITQLFLGIKHDWPSEEQRIAVQWVAGATAMATSLVIMQLTKTVHPPAGATALIAVTTTNVIDIKWFYIGVVTLSAVIQVTIGCLINNIERKYPSYWWKPSRLPLQVDPSTLGTVMPSVTTLTDREKEEVVASNLTAAEEGILEQRKPQNESEDEESISVVQGMIATRLNVKHAASMLKSHSKQALSLEEQKALSSLLDKITNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIZ0</accession>
    <name>A0A367JIZ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001219">
        <property type="protein sequence ID" value="RCH89839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIZ0"/>
    <dbReference type="STRING" id="86630.A0A367JIZ0"/>
    <dbReference type="OrthoDB" id="2263599at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="46498" checksum="4C029601741757D4" modified="2018-11-07" version="1">MSKRRRMAKQKTKNATKEMTDNYAPVQLEQAELAKQLERYIVEFETKVDQLKYKLLDKELVILFVANLHPRWKRLLEPIEHTFQHWKDAASIAVYHCVKVSALLGSERTDKSPLFTSQESIDILRSGYFASETHPDIERHPRESSIQHLIGTSTTALMPKKPATPSPPLLTTEMATVYSEKNKTKEKDNEKMIPKEHIRKPDAKEDKHKQDKKEVQKTEKKKSAQDDKSTKSKQTISSTTRNDNNIIETNNNTRNDSDSKENDIKDGNICYKIPECYKGVNLMFLELTINGKTVKGLLSKLSWGCSAISIDCVKRLGLTLSTSNLFCINTDFGIVNSLGFVKLPISHPAEPNIKSELITQVVPSIYNGKVELILGSDFFFKFKPTLNIKKRAIRFLDREASYIVHGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM36</accession>
    <name>A0A367JM36_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_010020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001037">
        <property type="protein sequence ID" value="RCH90988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM36"/>
    <dbReference type="STRING" id="86630.A0A367JM36"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH90988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="307" mass="34080" checksum="760C08F528DEC00D" modified="2018-11-07" version="1">MSQPPVQPPPPGPLPPAGFVRPPPNFPPGAPGFPNAPPPGSFPGPAVPAPSPAPFANAVPPAPQPKTQNGIPIDKQPLNTTPNRTVYVSNLNEKVKLDVLKNSLRTLFKQFGEVLDVVAHRNIRMRGQAFIAYPDEECAAKAIKELQHFVLYDKPMVVQYARHKSDVHAKKDGDYETHYKTRLARKEELWKSPLPGSHKPTFKAGKAASKSRGKGSNYNPTAHIPDEYLPPNNILFLQNLPETITQQQLIDLFQRYPGFREVRMIPAKRSIAFVEYENEIQSAVARAELSGHPLGPEQYMKVTFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM97</accession>
    <name>A0A367JM97_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alternative oxidase</fullName>
            <ecNumber evidence="12">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AOX1_1</name>
        <name evidence="14" type="ORF">CU097_008237</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01001062">
        <property type="protein sequence ID" value="RCH90821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM97"/>
    <dbReference type="STRING" id="86630.A0A367JM97"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="306" mass="35100" checksum="AECAF0F336EA1D3B" modified="2018-11-07" version="1">MIRTITQTSLFKTLPLARTVVFPSLTACRTLTTHQKLNINPDMPITMVREVLDSKPVPMCEEFIAGSRLTTETLENIDFGEGKHREPKTLGDKGAYYTVKFLRLLPDTYFGKDHYMRAVMLETIAAVPGMVGAMLRHMKSLRRMTEDHGWISHLLHEAENERMHLMTWMKCLKPSVWNRLLVLGAQGIFFNAYFALYLVSPKTAHRMCGYLEEEAVISYTHFLQDIDNGIIKNGPAPKIAIDYYNLHPEATIRDVVLAVRADEAVHRDANHFLSDRIAERKEDFLEDIKTEEYLHRPHNNTTPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMA8</accession>
    <name>A0A367JMA8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">QCR7</name>
        <name evidence="10" type="ORF">CU097_011655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001022">
        <property type="protein sequence ID" value="RCH91090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMA8"/>
    <dbReference type="STRING" id="86630.A0A367JMA8"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="14465" checksum="3A0A56E3B86D44A5" modified="2018-11-07" version="1">MSLSLKSFVQNSKLLSGLVKPLASAYANTAGYRQIGLKYDDLVSEESELVQEALRRLEIADPRAAYDRAYRIRVAQQCSLTHTLLPKEQWVKPEEDNRYLQPYIDQVAAERAEREAFDNIKVTPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JML7</accession>
    <name>A0A367JML7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001019">
        <property type="protein sequence ID" value="RCH91109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JML7"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="40"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="344" mass="37998" checksum="3DF30D7E5C20E250" modified="2018-11-07" version="1">MNSNNDIPLRGKDRNEAEEPFLPPPVQNKPVERDHPVTLIASVVAFYFVISLSVVFLNKIILSGSTEFPYALFVTWYQLVIALIILVIWAEIGKRNKMFSIIPPYEFDGTIAKRVAPLTVVYVGMLALNNLCLKHVEATFYQVARSLSINFTILFTYLILGKKTSAPALLACIIVFLGFAIGSYGEINFSWAGVIYGVGSSAFVALYGIYVQKTLGIVDNNPWKLLHYNTTTAVILLGIFVLISGEITEIIETSEAIYDVGFWILMTVTGITGFAINIAMFLQVKYTSALTNTISGTAKSCVQTILAAMIFQNEISGLSCLGIILALFGSGYYSWVRYKERLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPT9</accession>
    <name>A0A367JPT9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E2F-associated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000896">
        <property type="protein sequence ID" value="RCH91962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPT9"/>
    <dbReference type="STRING" id="86630.A0A367JPT9"/>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="20090" checksum="043F861941ED0A66" modified="2018-11-07" version="1">MDNQEMDRSNEQEFYDDIYFDTDQEDEDESMGLGLPNQKKKESKSKKILSNDELLYDPELDDKDEEWVNEQIVADSMDSMKGQGKTDAILTCPMCFITLCYSCQRHEKYADQYRAMFVHNCHVIKDERFKPKDAMEDEYYHKVVCDQCGVHVAMMDQDEVYHFFNVIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ26</accession>
    <name>A0A367JQ26_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000895">
        <property type="protein sequence ID" value="RCH91969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ26"/>
    <dbReference type="STRING" id="86630.A0A367JQ26"/>
    <dbReference type="OrthoDB" id="1432093at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="528" mass="61145" checksum="27604B52670E13C3" modified="2018-11-07" version="1">MEILKSDFEQKLPFIKKAILEADFIAIDCEFTGLTPPHININNTDDLAQRYSKIRSSVEEFTIVQYGVCTFKRDKETGDFIARPFNFYIFGNDPDNMQSRRVFSVDASSLAFLHSNNFDFNKWIKEGIPFYNFTEEGTFYESAYGTLRMNNRRSRIEESALTQSGKSFLEYNRKAINNWLQGNTEQPLIIQVNTPFYKKLIFQEVQENYNNFLQVMSRDIKHVEIVRLKEEQRKAKLQKTSALNFRTIIEAIGDAKCPVVAHNAAFDILHTTDQFWQYLPDNLTKCKEVVNSMWDYIVDTKYLAEYHPLLRGCFNTSVLGSLFNTVHTELEEAGQKIVLAPGFDRYIKSNKPNEHEAAYDAYMTGVIYLAFMMYINEQSDKQNNKENGEQINKPNGVENGVEDDEENKEQNGEVNGEQKEGDNNKEKGITLLGKRKRDLIDSDDVEDTIETNEEGETTESSEDEEEEKEEGEIESTKVIDEPSRTLFFNKSVIPYYGRIFLMRSDTPYINLKGEEEVNVESRKKSRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ71</accession>
    <name>A0A367JQ71_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_002415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000876">
        <property type="protein sequence ID" value="RCH92100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ71"/>
    <dbReference type="STRING" id="86630.A0A367JQ71"/>
    <dbReference type="OrthoDB" id="5588835at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="515" mass="59412" checksum="DBE3979C2F6C8250" modified="2018-11-07" version="1">MPRKKSVSYTEGSDIDEFENLSVGSREHQDTDEILTDDLLQTSSEDDKKRKKTAKKKKTLVKRKTTTKKETTQKGRAKVAPVKKEPEFWNSKRVEELRENYPDNYWTYHAESGHQMIHTINESHVLESIPCTINDQAPITSMALSQDGTLLATFSNIGAVKIWDVENDFALVRKLRDTEEKNIDEFYCGKFVANSEYMTVGGKLKDRHRWSAEDDDNHILPCPIKIFNVIDSKVVTKLEGHTEEILCIKALEFDGQNYLLSTSQDGSIIRWHMDKDWITFLDSTKMDDNITCMAFTVSFVPNTGNKYFLAATDEHVRLYDFENAQLLQTFSDLYSSYCDCGKFVRWLDESLYFSQYEDNDKERGEYAWFITRGAELCDVSEGVSSKPNTCTLHKLVYPTKDGEQFKFEQVKKYQDEDYHSNSWLVKIASNGRYLLAPTIYGQIFVFNMLSGQVTAILKDHQDMEVRDVIFHPYRPLLFSCGDDGCVKVYTYSENDAGKVEVEQDLDVGMIEIEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR51</accession>
    <name>A0A367JR51_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPT3 Dosage dependent suppressor of Ty-induced promoter mutations-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPT23_4</name>
        <name evidence="5" type="ORF">CU097_009997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000867">
        <property type="protein sequence ID" value="RCH92171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR51"/>
    <dbReference type="STRING" id="86630.A0A367JR51"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="293"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="511" mass="57244" checksum="C84FF8AEDC243FE0" modified="2018-11-07" version="1">MLSCPFRIRVNGIPPTGTKSRVETQIKLSIQLVPIDNTIVPSAPWKYLRVPEYLLARPKLKKMAQKQKLMNAEDPSDILDLEARVICESNKHKKIKMCQGCVRRERKRAERKKNAILTSIHIQPGSTVVDAEYERDRQRILLFNCDHLLDFNLHDTILPTRITCYCRHHDERIGFRVWFGIKDCKGNMVAVGQTPLIMVTDDHKTTKLNCSPRRRYRQRQAVECEPSSEDDASITSVLSRICSGVMAQPCDTKNTLDTSDPWQTEKFANQAVRLLDDTVRDYHSHDVMMLSANTVLEQSCAYLKHIAPSQGSLLGGTKVTLVGSGFCPDVGVMFGNSQAILLDVSSTSITCITPPGDHVGPVKITFKNYSFITTNNQVATFNYFDDSEQALMNLSYKITQAPSSIQDVSHVLSQHNPVDLMEIDSTGHTLLHYAAHLNHSYLAKILVTQCPQLVHVQDQNGLTALYFAIRSKSTHITQNLVQHGADTHLLSWYACKLGLQGSSTALKGDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR75</accession>
    <name>A0A367JR75_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000826">
        <property type="protein sequence ID" value="RCH92447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR75"/>
    <dbReference type="STRING" id="86630.A0A367JR75"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="127"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="238" mass="27877" checksum="D57613E29101BC58" modified="2018-11-07" version="1">MTSAAMNGFYQHSFQQIQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQQQQSYLSAYQQSSQMLLQRYNDSFYATDTTYTTVPNTHQLTEQHKRKIDELEYKKKPKSKKKKNKIVDPNAIPKPKRKTGLNKPLILSPVLSELMDGAKELSRPELVQKLWKYIKENNLQDPADRRFILCDAKLKKIFEQDRVNSFGMNKDLSAHLTKKEEVVDQAQQSSGSVSPLDKDGIPHDDFFLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRL0</accession>
    <name>A0A367JRL0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine triad nucleotide-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000806">
        <property type="protein sequence ID" value="RCH92592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRL0"/>
    <dbReference type="STRING" id="86630.A0A367JRL0"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8990" checksum="1923E0ED5D92E026" modified="2018-11-07" version="1">MTELGKRLLKEEGFNPEDETQIRLGFHVPPFNSVNHLHMHVIGLPFKNKFRYLKYKVGLPWFMDINALFMSLKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT65</accession>
    <name>A0A367JT65_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000733">
        <property type="protein sequence ID" value="RCH93162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT65"/>
    <dbReference type="STRING" id="86630.A0A367JT65"/>
    <dbReference type="OrthoDB" id="2241808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="389" mass="44364" checksum="217DBFB001004809" modified="2018-11-07" version="1">MSSTSNSNLIYNTSNYFISSASNPTIYPQIGSQNTFTSPHLAYAQQRRPLTSRAKLTTTLWEDEGTICYQVDANGYCVARRQDNDMINGTKLLNVAGMSRGKRDGILKNEKGRVVIKVGAMHLKGVWITFDRAKLLAAQYRIQDLLYPLFVDDPTMFLYSSLHNPINRFDNYRQHYLPPSNWDRLQPPSTETVYNRNTEFNTSSMVSTSSDNNNNNNNLFLTQLDYNNKTGASKLPLVSGDFTSYTNPAYYSKQPKQGQPQQSENNKLYEELMASTIKQDFNALSPNYSKTSTETGKPLTYLSAFHSPYSRPNAEYDSSSSTALITPSFGSSRRQSIAKSNQKPMVVRHHPYMTVNKNMQHFQQLNYKEEEYEKKGEAIPTEFNNKHPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUY6</accession>
    <name>A0A367JUY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_011869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000655">
        <property type="protein sequence ID" value="RCH93792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUY6"/>
    <dbReference type="STRING" id="86630.A0A367JUY6"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="22613" checksum="368BA556F90C484A" modified="2018-11-07" version="1">MVSECDNSKGICDAGKTAMYTLLRFNEKRPTVSSMKENEGQLVLSNKTYDLVDLPGHERVRYRYNDFLPVTRTIVFVVDSTTLNRQIRSVAEYLYDVLAKAQVQKNRIPILIACNKSDMITALPTDKVKLMLENEINRLRSTRTARVEQSEEDEAEAYLGYEGENFKFDHVDNQVEFVSCSVEKEDIEKVQEWIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVH9</accession>
    <name>A0A367JVH9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000637">
        <property type="protein sequence ID" value="RCH93943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVH9"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="71" mass="8151" checksum="CF2028567C3DCB1D" modified="2018-11-07" version="1">MSESDSKSRSNKPMKYAQLHYELNKLTKNIQELDQHFKQTNEQVPALLKMSTLHAAMLMSAQSVLNKEDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVR2</accession>
    <name>A0A367JVR2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">IRE1_2</name>
        <name evidence="24" type="ORF">CU097_011900</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000632">
        <property type="protein sequence ID" value="RCH93987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVR2"/>
    <dbReference type="STRING" id="86630.A0A367JVR2"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="22">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="745"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="23">
        <location>
            <begin position="1043"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCH93987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1174" mass="133977" checksum="BB44A025D6F65BB5" modified="2018-11-07" version="1">MALFVARIPRDMNNRELEDAFSKYGKITRFEVKREGFGFVEFDDKRDAEDAMKGMHESIAELVVEWAKNGGKRPSDNECYHCGKSGKSFRTSTHSLFHWFTFSALILLSLLAIYCVECKSHYELEPYSKRHLLESPIQKEAELLSTDLILVFTLDGSIRGIDRYDGTSYWTLQGGQRSSLIKADSQFKTHEMKLYDDSDDDDDDDYNEEEGYSGLFNDLVPEVHEPEVQENDILKIKNKKSKVDDSIKEDDRDLQQDVYYIIEPQDGGNLYIYGDGRPLKKLPFSIKDIADKAPIRTADGINYIGGKNTVMIAIDPRTGKILQQFDSSKQGYNHILSKKKLGPGTIFIGRNEYKVVIYDDNSRKLLNITYSEYIPNRLDNDIPLSKASSDIYIASSADRSIMAFDVTGKDMWVKDLPYPVVSVFDVYRQADSIVLCKHEPPISLNRSIIGNALRLMNRSRDLVTAYVGVHEDSLYAMSTKYYPLMQLSAWSSMYTGRSPDELPNLTIDGPQPNTSQAEWTHVQPHPSCCRGCQNHIKCIVGQHVVQNTVIDSPYQKLTFDDEDIDQDDHTDDSDQDEMRDGYIRHETKTGFFYDGFGKFWKSYMLVGAVFVYVYRDRMVTFYEVKVLPKWKQIQKKKAKVKKTKARIAAAIQEQKEKIKRVRKSITMGSVEILKQGSSSSGIKILNEQEEKINTSQEKAENDEQKEMKEEETKAPQAETKVAVVKTVSDGLDLENFKQSKSTVLEISETVLGYGSHGTVVYKGKFDGRDVAVKRLLVDFYDVALKEVQLLQESDDHPNVVRYFYKEQSDRFLYIALELCYGSLNDYMDRTLSIADLQLCDAMNPADILFQITSGLQHLHSLKIVHRDIKPHNILLAPTKHRMKHAAPMRILISDFGLCKKLDGEQSSFNYTAASPAGTSGWRAPELLAGALATEISDTSNSSSSLVTDPNMMMGRRVKATRAIDIFSAGCVFYYVLSRGDHPFGNRFGRENNILNNVYDLSKLDSMGEDGVEAKDLVERMISTDPKARPTADAILSHPFFWTTSKRLSFLQDASDRFEVEERDPPSPLLLELESGADKVIGGDWYRRIDRVVANDLGKFRKYDGKRVRDLLRALRNKKHHWQDLPDQVKKVYGEPPNQFLYYFTARFPHLLLHTYYVVANHPELRKEGSLGQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVW8</accession>
    <name>A0A367JVW8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000620">
        <property type="protein sequence ID" value="RCH94083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVW8"/>
    <dbReference type="STRING" id="86630.A0A367JVW8"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="132"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="304" mass="34297" checksum="487577572DAD3BD0" modified="2018-11-07" version="1">MGDIKGSSWSSIKDTLNLNSEDESRSESESSTDIVKFNTDDMVTLGSMPMEEETIVVKCSNCQRPVLPSKFRKHAETCLGDRLMSSALSNQEYALKSSDKKRRLRPGSIEDTDTDTESNGKPILEKKKSKKLRRGKAPLDLDKQCGVIYGPDGLPCTRSIKCKTHSMSAKRAVEGRSQPYNVLLAAYQKKPIIKSIGNDIVLNDSEQLLKHHKKLQEKSLLLHSNKPSKSEPLAKQGKEEEFYADSDEELENVMQALQFSQPRPLAEKHYSYTKRKRQCIRLRTILLDAITPKIGIENDGFRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWR5</accession>
    <name>A0A367JWR5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000585">
        <property type="protein sequence ID" value="RCH94376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWR5"/>
    <dbReference type="OrthoDB" id="2262162at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="454" mass="51230" checksum="AD0D659BE6FBE5F3" modified="2018-11-07" version="1">MISCAQLSFSSFVCLDVSTVLQVATQHNATAPITAPTSLSRIVPLLLATVFGGVAFLLGLYSNKGGKYLYRRIVVGFVLATSILIAYTFGSSYQHYYQMIKETCQDTSNKVYCARHVVQAESILFAVALGLLFLSLLFWTIASAFFTKSANDNVSEKEEETEELKPAFMSQTHQRNYSPTTSDYTPSKTTTAYSSQDELAVWRDVAMFDRDNIIWEEDKQNLYHHQNGSKGSSSTDTAEYYKKPTKRYYSPVEKSLSPPPASASKSSRRDSPSNPHGYHRQQKRRSSNNANYQQQHKMSKRHDQKYNHRQQPRKESQDSTMTFGGYKSRKPSQGYSDWEQRYQTSRLSMGGGGGAMKTPTSMSPHPFQYPSDASNARNSFCMTPNFDDQPSEPSSNSYFPQQEHRKSSTSSLGYVPILNMPPSGTPESAIEHPLNKKVITDKRIQDYLQNSRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXB0</accession>
    <name>A0A367JXB0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000592">
        <property type="protein sequence ID" value="RCH94301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXB0"/>
    <dbReference type="OrthoDB" id="2270879at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="73" mass="8790" checksum="074E4547463ECA26" modified="2018-11-07" version="1">MDWEQNIEPFNIRASMMELAEDMEVHEAKKKNNFYSDKQRALFYCYNMMKLWKAGVSKRIAQAWAKRLKKDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXL2</accession>
    <name>A0A367JXL2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000553">
        <property type="protein sequence ID" value="RCH94658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXL2"/>
    <dbReference type="STRING" id="86630.A0A367JXL2"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="248" mass="27696" checksum="043250634B72A4F7" modified="2018-11-07" version="1">MTFKNPATLTQKGHAEVGQSRESKPVKIYYEIHGNGPQLVMLVMGLALACGAWDYQTKYLAETGQYSVLVFDNRGVGHSDAPIGLYSTSQMAQDALELLDHVGWHDRVHLVGISMGGMISLEMVDADPFRFISLTLTSTTARRNIPTWAAVSALSRIAFIYRDPKDQLNAAIDLVYPPEWLEQKPENSTKYATNRELASSLLIRRMRATRRQPLHGYLAQLAACLRHSVSDSRLAHLITLYDPLTHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZF2</accession>
    <name>A0A367JZF2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">WDR12_2</name>
        <name evidence="5" type="ORF">CU097_014414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000481">
        <property type="protein sequence ID" value="RCH95298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZF2"/>
    <dbReference type="STRING" id="86630.A0A367JZF2"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="287" mass="31951" checksum="D173649D490E2166" modified="2018-11-07" version="1" fragment="single">ECISTLVGHTDSVKSVALGRVDDNKAIVFSGSLDHSVLAWEYSFDDESYRLMYECKGHKGPVESIATDSTGNYIASAAADGIVRVWTSSEPTEDESLEEEPKKKKKKTVNSRKIKTKSLELEGHVGAVNAVTFNTTNSNIVYTGGWDHSIRSWDVEQQVNLVTKNCEKVVLGVDYSSRAQLLATGHADNTIRLWDLKSDDGTNVKLTLRGHSAWVSSVSWSKTSEHMLCSGSYDSTVRVWDIRSSKEPLYTMDSAENKEKVLSVYWDNEKILSGGEEKKLRIYQAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZK4</accession>
    <name>A0A367JZK4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Karyopherin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CRM1_4</name>
        <name evidence="7" type="ORF">CU097_012267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000474">
        <property type="protein sequence ID" value="RCH95373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZK4"/>
    <dbReference type="STRING" id="86630.A0A367JZK4"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="982" mass="113937" checksum="0BC12BF7D625CB08" modified="2018-11-07" version="1">MNMPFDVTELDRTVKAFYEGNDTGRQAAQAVIADFQKDPNSWQIVDQILEQSSYLQTKFIALNILEDFIRVRWNTLPVDQRLVLRNYIVKMIVDISSNQSSFQSQKLLLNKLNVVLVQIVKKEWPKHWPTFMQEIAESSFAGITLCENNIKIIRLLSEEVYDYSTSSLTQVKMKRLKEQMKLDFSLIFDLCNKVLMSANKRSLIMETMCTIQNLTTWMPVEYAYQDGFIQLIQTKLHESPYQLLALQCFNGILNLENTIQPRKVYDIVFPYINSMKEAITNSNYEQNYALTKEVAIFLITMLTKHKDCVSDVNQLLLYLLSILRMPDLDICKICTGYWETFVEQGDYRQIQRELAVVITEIMVMPNDILRVQDEDGEITQEYVKQSDTAALYDSMQHILQAITKREPEFIQSVLHDRLLKIQIATDITTHYDMLFKISWAVGALSDTLTVETEKAFLKTIVQDYVQLSEKTKSQDWAVISCILYISGQYPRFLSFHHDFMNFILQKVFVLLYELNSDVKDMACNTLLKVSQGFHKQSLRNEVLSETLINQFEPLSTHLNQHQASMIYESAAYIILTMPSLDLQLNYLNSMMAQQNAVVGESFDLLKHQCLINVKFIHAVGSNSLDSLKAIIQYLKINIVICNVLGNLYCHHLKQITPLLIECYKIANGDENNSLPKHIRKAVIQLLECFILSINSQVDILEIQGLLQVIAADYVQSSDQREPLVLSLLANIFEKIDNPVATVWPAILNQTIDIVFSHTLSMLTQNFSDFPDIRTQFYRLMEVIVKRYIQDIFRTPELLDSVINCIIWGTKHTQTEISHTAMKTCLFVLDNALQEEDDVASQFFETYYVRILTDTLEILLDPDCRNGFEYQTQIISKMLRMIQEGEIYTRVFNPEQVSNPLMSNMEFLQNYILDLLTNTYPLLQKSQLEVLVMGMFDYSDDLQRFQNDIQDFLIDIREVDEESVGYERVQEETEAELELLRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0Q9</accession>
    <name>A0A367K0Q9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000437">
        <property type="protein sequence ID" value="RCH95729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0Q9"/>
    <dbReference type="STRING" id="86630.A0A367K0Q9"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="784" mass="85572" checksum="42780E548215DAD7" modified="2018-11-07" version="1">MAFSKTQGKKQETGTGPHLKQQRGNNNNSTNNNNVKKWPASNPSQRNNNYNAHSNPSEVVVEDQASAKEMHDRMLFLLGNMIGAIVEATVKNGCKFRGIFHGASTEGDLAIALSLAQKIFDPLAPTDKDKTNPNPIINTLLIYSKDLVEITVASVDLTGAASERNTFKTDADIAGKLEIKERELHKWAPTDEDNALGLLDGDLESSGETTWDQFAVNEKLFGLKTDFDEEIYTTPLNRSAPGFKDREKKAIQVANEIQKSAATNVHILEERGISIDDSGLDEEDLYGAVVRDGNKYIPPALRKQYQQSQEQNVQQAKKETKNNNKSINKIITSDLPKSAGSNPSPIANLPTTRRESNEKGQEKTKENEPPKRIESEIASTFKHFAMMEKDKLNAKKQALQKKEKDGRLAELKMFHQTFKLNVPVPADLVPLLSKGKKSSPAMSTSSLGSVSPDEKKKKPELSTPPSATTPTPAQAVTEPVKKNSPVQAKSPLPSQAASATSAADATTNTNKTNTPTPSQNTTNTSSTTGSTFKLNAKASSFKPNPSAAAFVPGSLTTSVQQDDPHSFFGNKHPKKNLGNDKITMKEAFKPPFLKKSVSANSIGPTWPFGSKSYRVQFSQFNVYDEDVFGGYPSPGYGYAYPQYRYPQYVSGVPQMAVQQGVPYMSPQFVSSVPISAPMPPNAVPPTAAYSPQMANVSPHGSPFPQGFPSPQRSPMVPQGMPPQVYQYQGAPMMMRYPPEIMMNNAGGPPMMMQRPVMMEPMQYSPHQQSETSANDSGAETPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0S6</accession>
    <name>A0A367K0S6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DNA repair protein rad2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RAD2_2</name>
        <name evidence="17" type="ORF">CU097_012130</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000460">
        <property type="protein sequence ID" value="RCH95501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0S6"/>
    <dbReference type="STRING" id="86630.A0A367K0S6"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="796"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="587"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH95501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1055" mass="121370" checksum="BB3F35D9672A3E82" modified="2018-11-07" version="1">MGVQGLWTLVGPAARPTQLESLRQKRIAVDASIWIHQFMRTMRDKQGNALRNGHLLGFFRRLCKLLFYDIKPVFVFDGGAPVLKRNTIRERRRRREGMKINMKATARKILSAQVKSRVIMEEEKKRRGEQATNDEEYVYYEQLEKSAAVDVLRKNRKLDQYELPEINQNQIHPDRVDPRLATAQEIKEFIEEYMPSDMDIDSETFKSLPPEIQYEIIQDLKLKSRQTSWARLDQMIRNSKTALDFSKQQIKLLKHRNEMTQRVMQMNTVAGGTIVSEPARVAGERGREYILYKNENIEQGLGWKLPGISAANPVYIDPVQPPTSATEDIESTSTEKKDQVDKVKEAVANNPKLAALLNGILSDEEEEEEEKDKGQTDEEPFTSIISEDEDEALFMDYSKPNENKRDHLLNDMNAYADDEAIDQVISRIYAQDAQDARELNSRAKEEQGNSALSLGPDDFLNLWISRAPDAFLYLYSFNDEYKRILRSAIFDSDIPTLQNQLMSIRKQFGKTREGDELALESLQFQESFLENVIQWKQNNRQQHNVIAREQQPLKTENDLIEPTLEDNIIQDTSIFDDDDDEIIQFVEAGSSQKSETDDKPSQSVTPLREPVHINVSQSLLYTKPDEKSGVNKISENEDNRKQEKDTQADKNTMSPEKIGYNGQTENNEEDDDNESTSIEYEEVIPMHTFDNVNSSKEKEANDEPQRSDKVENEAVAVTVTANGHGYDSEEELDDNVQGEDDEYARFISNIASRNIEDVKRELYEDIKDLNAQQRKEKGNTDDITDQMIQDIQELLKLFGIPYIVSPMEAEAQCAELERLNLIEGTITDDSDVFLFGATRVYKNMFNQQRFVEFYKSQDIEREMMLSRTKLIQLAYLLGSDYTEGIPGVGPVAAMEILSEFSSVDDEDESVETPLIRFKDWYNSGQDTTDFQKKFRKGHKDLEIPADFPNPLVKEAYLHPTVDSSKQQFKWGQPQLDSLRVFLMEAFGWPEEKADQVLLPVLQEMNKRTAVGEQSTINSFFSPTTGPVKDITGSKHSSKRVQNIVEKWRKQKRAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3F2</accession>
    <name>A0A367K3F2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_014418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000348">
        <property type="protein sequence ID" value="RCH96669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3F2"/>
    <dbReference type="STRING" id="86630.A0A367K3F2"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="824" mass="93869" checksum="CE58091AF92D8AA9" modified="2018-11-07" version="1">MTSANSAYSDNSVMSQLTIEKTLEGHAGCINTLDWSSSGEFLLSGSDDTRLNIYNAYNNFSLQCSIQSGHSANIFSAYFMPNTSDRIIISGAGDSEVRIFDCAKEAPLTNMYVCHEDQVRRLAIFKNNPNEFLTCSQDGTVRHFDLREPHICSNHSVRSFMTAQRVPTRQIPRPHGPGVSRGCPKPLVDYRKYKLDLNTISINQLNPHYFAVAGQNEYIYLHDRRMPSRTDAPTVECVKKFTSTSDIFRRKGKHVTALLGSWSSDGVYLFNINDSPLEPLSRNSTFESLTEPRNLRSRTMLRTSRQFMDEYERRRRMRSTEWSSLLNTFKTKPYTETIKASKKLLHHAVRDHLQLSNCTSEKVPYKDKLIEECKLVEVSALMISALTRIRKLIDSSSDHVIRNDVSTVSFTNRTLEDFTNRDFLLAKEELAQAKRIASHTWKGQFGLAIGYFYAGCLLLSFQNCPHRRLFLHQARLIHQRACRTFSALGLSDYASRKDLAFTMVREIECSSWLNSFRHEILEMCRTAGSLTSMSDPVEIHWEYLRYMVIDADIDLSVYKKDDYEDDTRMIVDDGDDAHNTTDEDDSDDDSSSDDEQNDDETINIYSDYDLTDDDILEADSSEFAIHRLAIHGFILNHFFPDDLDLGAGNTDKNIYPEAGIVPHRKKFTGHRNIETVKEVDFFGQSDEYVVSGSDDGLLFIWDKKTAKIVQVLKADDEVVNVAKAHPYLPVLAVSGIDTTAKIVTPKAKPFLTSRVTEPKRASSYSPSSRLYDLEYIISKNQKIRGINGQNDIEYLSNIYKAQDIVAAIGLKLEKSSYHDYDDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4M9</accession>
    <name>A0A367K4M9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000304">
        <property type="protein sequence ID" value="RCH97138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4M9"/>
    <dbReference type="OrthoDB" id="2274111at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="327" mass="37151" checksum="0BFEC4F852F42F20" modified="2018-11-07" version="1">MPLIQNSTSNSRFQTDTASRVRNVSELECSNFSDAYIYTKFRTRFLSRYIYSDPEERHYYARHSLHSRRSLIEDEEDEAETVVTGPRYHASSSNSSSSSSTISTGSSSSSSNSSSTSNHGISSSDEDDTTGTFHRSPIDLYRLAIRTNNEILEDLAAIIRILRQMNTIYRIFNNNNYHSTLGYSAEGDEEEANKLLEAGLSDLQSVLSTEHKRQSTLALLALLTCHHHNEHGHGCSDQYLRQYLDPDGEYDPRLAIFAAAIYDDELELEPKSCRDIMIAAEEICGPAWLDEFHKEKESALRKMLEKLAFVAKIRLKIRDESNTRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4P1</accession>
    <name>A0A367K4P1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000307">
        <property type="protein sequence ID" value="RCH97105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4P1"/>
    <dbReference type="STRING" id="86630.A0A367K4P1"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000658">
        <property type="entry name" value="PRK00029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="582" mass="67003" checksum="216FCEE07979311E" modified="2018-11-07" version="1">MSMTKMMRTLESLPSLPTKFTKSLPVDIYTANVTETNTNNLMRTPRHVLNAVYSHVIPESAPDPVLLGMSKKACEDLDLDYNDLVQHHKEESAQVFSGNRLLKGTRPWSLCYAGHQFGYFAGQLGDGRAVSLFESKNHKGEHWELQLKGAGRTPYSRFGDGYAVLRSSIREFLMSEYMNALGVPTTRALALIGTSREVYRDDGPMGGQPERGAIVTRMAPSWLRFGNFELFYSRDDMENVRVLANYAIDNVVGQDKEDTVSKETDNKYARFFRYVTKMTAKTVAEWQAIGFNHGVLNTDNMSILGLTMDYGPYQIMDYYDPGYICNHSDETGRYAFYRQPNACLFNLVKLSIPFYELIGAGDLADQIVFPTEDNKETATDETTLEAYRKKGQEFVIQLLSNEYSQHFHKHLANKMRAKLGLAKELEDDLEKIITPLFDWMSMFKVDYHRFYRSLSNYDMESSVQQWADISTKNPLDKKDCEEALKDWLDTYRERLMKEDEADLKARKERMDSVNPRFILRNFILEDVIQEFNKSTDEQATKKLEACMDACINPFNQRYDDQVEQWISAKVSTEEDFRCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5A1</accession>
    <name>A0A367K5A1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALG5</name>
        <name evidence="15" type="ORF">CU097_009044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000285">
        <property type="protein sequence ID" value="RCH97340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5A1"/>
    <dbReference type="STRING" id="86630.A0A367K5A1"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="62"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH97340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="314" mass="35839" checksum="215BA812FB0C2F10" modified="2018-11-07" version="1">MSLLDAISILLVTIISIIIGFLLLFSPKPRPRTENETYYRDASSEKRKPLPDLFDEPSVKLSCIVPAYDESKRLPKMLKETVEFLEQKKEMDKDYSYEIIIVDDGSRDNTIEVAMGFAKKYPHVDIRILAMEKNRGKGGAVTQGILGCRGELCLMVDADGATKFSDLDKLLEELAHIQKDDYAVVVGSRSHLVSTEAVVKRSFIRNLLMRGFHLLVYILGIRGIEDTQCGFKLFTRKSAQIIFPNMHVERWIFDIECLIIAQQQNIPIAEVQVTWHEIDGSKVNLMVDSIKMAVDLLLIRLNYILGFWTVRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5I4</accession>
    <name>A0A367K5I4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_006244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000278">
        <property type="protein sequence ID" value="RCH97430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5I4"/>
    <dbReference type="STRING" id="86630.A0A367K5I4"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="126"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27069" checksum="E8A42B47CAF37AC3" modified="2018-11-07" version="1">MAVEEKKRKHKDKSEKKSKKKHKADKETRIEPSSTTISAVSANAPASSFSEVHARLYIHLAPMWAGKTMEGVNEQLNAFLMKYVPEVDGIVLAHSDVKFVSDKGKIMYDSPFSHFFISVKFLIWKPKKGSKLVGRINLQSEDHIGLLIYGTFNASIPKSRIPSSMYEWKVSEEDDAPVQEESSIDEDEDGKESTPEERKRTQYGEWVNKQTGASIGGDDGTVEFTVIDIIEANDILTVTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6E6</accession>
    <name>A0A367K6E6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_014628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000254">
        <property type="protein sequence ID" value="RCH97726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K6E6"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF11">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016611491" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1215"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1268"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1298"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1368"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="425"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="523"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH97726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1412" mass="159116" checksum="2C28680DBD86A14B" modified="2018-11-07" version="1">MKINKILCGLSAILCGVNALPLFEVANQYDRHGNKCPLLPHYNVSCPTLCVKDQKSCPSALSPTCPPGLSFCGDGSCHESCENIANVCQCGDDTVQYFPCAAGQLVNITHFDPQNQVTQIQNTCAAAANITASDIGVWGVFNTSSIWLSCPVIDPAFTYKEPMWISVWSLMSAEAAILILWAIYKYLREMKFRNAMAARMKSEKMAANNQEDEVDETDFKKEIMKVDEKKPASAASTSDADSLKESERLKFRGYKNDFFGYIAFGSVVITTLLFFVFLGVLVGDYYGTVTGVALQVFLSSDLSSKIFAAVWHISAAWFCIVMLTRKTIRNYFRIESYPHKCPYVQVERKQEELIFLDDGSKWLAKLRSIEQRIYKHFGLDILVTTCTVRTKNSLRYFEYQCMRYIYNSEKSRFEPYEYDLGSTNKKLQSWSSGISSQEAENRLSMLGPNIIQVYVPSIPMAIIQEFSSFLYLYQMMCMWVWYYFQYYKMGLVQTCIILFSAFIRIFLRLRADHRIKDMAEHVTDVTVLRDGQWIDTSSANLVPGDIFEVKENTLVPTDAVILSGTVVVNESSLTGEAMPIRKFAIPNDDNIYEMNGSGKVNTLFAGTIVSQVTPAINTTEEKNRVFALTLRTGIATEKGMLIHKILFPAPVSFIFNEHIKVAISILLVWGLVAFCLSLYLMGRGNITSWFYGVFVMSEIFSPLLPAAFTINQSVCAARLRTKKILCIDLPRINLSGKVRIFCFDKTGTLTREGLEFYGGVPSPVGKAAAFGDRQEDPLTMEPLLAMGIATCHAVTQVKDQFIGNPVDIESFNSMKWKLLPPAKPEYLDTLVAPSTSPEKEGKQVHVVRRFEFVHARASQSVAVLDPETNQVHVFLKGSFERIKHLSNADSLPADYDQEAAKHAQVGCYVLALAHRTLGTLDVDVTMEQIKSMTRDELEQGCDFTGFVLFRNMLKHDTTDAIAELKNGDTRVVMITGDTALTGIYIARQCGMIESHQRVLLGDLVSGSVVWHDVDSGEQVDVDEVIQADTHEEHEKRVELAITGRAFEALISQGKMRKYLLMTRVFARMTPNDKVMCIQLHMEKGITAMCGDGGNDCGALRAAHVGLALSEAEASIVSPFSTSNRSIMQCVELLRQGRSAIATSFANYKFLILYGECMAFWELCMFYFTVISPQPVWITIDGFITTTMTLAITQALPAKKLSPCRPTAKPLGAYTLASLLGVIFINFWFLVCSIVWLFQQDWFICNQFDSSAIDSAKWWLLGDNYEAEVMSIVILFQFFNNGAVVNFGSQFRQSWWRNYVLVFVWCAFFISTSYITLANPNPYGCIFRINCGSPEALVSLGYPEPTWYIDDYNFPLKHNVLPVWFRWQLWGYVLANCACTIIWERICILWIARDWAVKRKATHPSKNRVIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6R4</accession>
    <name>A0A367K6R4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000238">
        <property type="protein sequence ID" value="RCH97914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6R4"/>
    <dbReference type="STRING" id="86630.A0A367K6R4"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24174" checksum="6EEBC9DD83C62603" modified="2018-11-07" version="1">MMAIHLKISVAMLIPINILKMISILGIILVFTSLIGLLGSFYRERRSLHILCTTTVIIAFLYQISIAIMVYNQAAHTTSWLSEAWAESSVDYRLYAQTKLHCCGFTGPSDHPVPSPTCVPHQLTNSEQPCRDPMNQYMREELTHIYIVLFTSLAIEILALCNSITHLCTMNPTRSWEVSPEHVEQKKFASMNEYNASAATLVNPVYSKYKRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6R5</accession>
    <name>A0A367K6R5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000242">
        <property type="protein sequence ID" value="RCH97860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6R5"/>
    <dbReference type="STRING" id="86630.A0A367K6R5"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="22880" checksum="7AB6C7F76956A411" modified="2018-11-07" version="1">MNSLTKSVAVFGRATKQVYFTPAASLHVSSLLARESVVDKAKNVADQVNKKTGEKLSDVLEGAEKVTETATHQAKKVKDKATHLTDDAMHEADKRTPSEKTILETLKGGVEAAKEAVGLGSKKASHAAEEFKDEAATKAKRVMHSVDEASDKASNAAHHAKKTAGSVADDVKAKANETARDARDTTTNVAYEAQNKAANAATGAKEKAKKAADSMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K709</accession>
    <name>A0A367K709_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000230">
        <property type="protein sequence ID" value="RCH98013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K709"/>
    <dbReference type="OrthoDB" id="2275666at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="20014" checksum="1D948EEC89694C90" modified="2018-11-07" version="1" fragment="single">MSITLLENHSQVIGYMNQVYLSCTPPDQKLFREQAYVNEGDLFRNNSHHESRKYKKNEQKTRRRLLWALKKRHREPIAKKLLDVGREHKMRIENLKKDGYQVTGYLRKSSGKGDASMRLRLLDLMVDRLIKDSSMDMVFASYSSSSKQPFTDHDRTDPLRAPKTLGSTQGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7A6</accession>
    <name>A0A367K7A6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000254">
        <property type="protein sequence ID" value="RCH97721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7A6"/>
    <dbReference type="STRING" id="86630.A0A367K7A6"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017051608" evidence="5">
        <location>
            <begin position="21"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="558" mass="63527" checksum="0D1D181C57DA2303" modified="2018-11-07" version="1">MKLSTLILALFTVASHLTVGSTQGTFDLIANFREPKNILFACNIGGSSHIVWVLEILEELAARGHHVSFYTREDQAKFIQNYPSVELVLNGPALFQPEESRALLERLISMEVVKGVLEKEQLILMNIKEEYYKFQKTIDQKKIDVVLCDYLNVASVEAAKSAGIPNVITVTMVMGPDVSAPYINTNFFNVHHPMSKGVPFHERLVDRVINPLRYYIGARFFADQFTQEQMSVGIEPKLSVLERWEDSMKIVNSVFGFEFPRPMGPLVELIGPIVPRTYPTLNDELQTFLDHRLKVVYVAFGQLTVPTPSEIKFILTALLENMETKYIDGIIWSTRGIREHFPDIITTRTNTTYDINNFFTNPTDDSNIAFVNWAPQVAILHHPSTCLFLTHGGAGSLYESMHAAVPIAVFPYFSDQPATAISAEEHGTGRWLRRTLRQDQATDLIKEIVDDTVGKYRRNVDRFKALVQIRNAHGKQRGADLVEEAIFTHVNGKLKHRRDIRRDLSFFKAYNLDIYSFVLVSLVTFAYGIYRFVFMLYRMAFNAVSVPRMALDKDLKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K862</accession>
    <name>A0A367K862_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000203">
        <property type="protein sequence ID" value="RCH98357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K862"/>
    <dbReference type="STRING" id="86630.A0A367K862"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="38570" checksum="727D862AAACF33F5" modified="2018-11-07" version="1">MLAHWKTSSSIILSTALLFILYYIQFKNKEKAIAEIETSSSDHPCSCPPKINTQFGEQRPVIVPDTMPSIPSDIRDKIQENRLENDDLIITVAGYDMRLDLYNWIEFMKAANEHRFLVFCTDSDLYRHLTIAGYENRAVLVPDDWLWFSNSSSYTPWILERLVHLDINPLMLDIHQLILWPRAREYVSTMMHVRWDTQLIATGRDASHLQGGLIYLMRDSYQVKRLLAQVVQSQMYEPTLSFQEVFHQALSQTHIHVKSGFVLLLDDIHFPNGEVYFEQKHSGTAGIEPYMVYVNHKSGKERVDLLKNNSLWRVDEDRVKQIDDQLAAALNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8N4</accession>
    <name>A0A367K8N4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBP12_2</name>
        <name evidence="11" type="ORF">CU097_012239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000193">
        <property type="protein sequence ID" value="RCH98489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8N4"/>
    <dbReference type="STRING" id="86630.A0A367K8N4"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="303"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="759"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="849"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1185" mass="134114" checksum="4CC220A0D8F3FC35" modified="2018-11-07" version="1">MSDNETDKSPISTKRARESSMEEDVEERASKIDPKDQVKIITQLQQEHLSEGQTWYLISKNWFTRWRQYCSRLSSPQHDARKIGEQTNPGPINNQSILQANGKLVEGLKLNDTVFAVPEEAWKDLTEWYGSVTEPIERLVIKGADGELTVELYPPHFKLFVITDSTSTQLTRCPQFTLSEVSTVNDLVSTIKESLDLSQDAELQVWTLEDEPTTPIISSSVLQNASQIDTENGSASLSRSGQCNIAVAIKGDARFPSDVKQSDTSSVSSASSIFANGFNNLTTTSSASTPTSGSYSKFTRGVCGLQNLGNTCFMNSALQCLSNTPELTKWFLADNYKNELNRDNPLGMKGQVAEAYGELIEKLWSGHSHSFAPRDFKYTIGKFNSSFYGYQQHDTQELLAFLLDGLHEDLNRIIKKPYIELPDFDGMKDEEIAKKSWDYHRARNDSVIVDLFQGQFKSKLVCAECKNVSVTFDPFMYLSLPLPIKKKSKTTIVYVPYDPMKRMQRVVVTLSKDASIAHLQREVARMMSVEDPSTLLVVELFSHKIYKVFPQYEPVATIGSSDTIYVYQLPGPVPPAPKRKIKSYRFGKDDDDDNEDSTSEDDDQLIVFPVYCATVDKSEQAAYTSPQQFGDPFVIGIPRKYCTNVDSLYRLLSQHVERYTHFKLFEEVNGDAEMEDEPPKYEAVVTNGHQQDMDIDEQQQQQPIHTAAAVTAAGGKKTEPMSNLFNIKVFSGGHTYGRHTEDLLPCTHGLTPWTDLRERAEEEQKQREEYEIQQSQPDFDGNDTEGLPETENDDTEMEDSIVMSSSMQDEEEVENAAVNFYQNDTTATTYSPIINPATDNDTESILSNENNVGSKPESPVLDSFTTPPQLPNSYDTMSHKPTIPVKRKLTCPPSTIIRQGEGIVLEWTPKRAQQLFGESPFSSSNGVSGSGWEDIEELGDPEEAMAGPTDAKNKQQITLADCLNEFTKEEELGEEDLWYCPKCKKHQMATKKFDLWRMPDIMVVHLKRFSHSRTWRDKIDAFIDFPVESLDLTDRVLSINNKDALKEEDKLIYDLYAVDNHYGGLGGGHYTAYAQNFEDKNWYHFDDSHVSKVDVSDIKTSAAYLLFYKRRKPQNQVNEKCVEEIIQETKERQQAAEKQNETDNIMSDDQVLSAKEEDQDQASETNTITNRDELRQNNDDDIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8Y0</accession>
    <name>A0A367K8Y0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 6</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UBC6</name>
        <name evidence="14" type="ORF">CU097_012799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000186">
        <property type="protein sequence ID" value="RCH98579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8Y0"/>
    <dbReference type="STRING" id="86630.A0A367K8Y0"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH98579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17584" checksum="3CE1AB6AE7A1073E" modified="2018-11-07" version="1">MATKSAYKRLTKEYLAIQKNPPPFITAKPLENNILEWHYVIRGPPDSPYAGGEYYGRLNFPAEYPFKPPSIRMTTPSGRFQPDTRLCLTMSDFHPSLWNPSWSVATILNGLLSFMVGDEATTGSIKTSTAEKRIYAARSHLWNLNHYKFRGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K911</accession>
    <name>A0A367K911_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_013347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000184">
        <property type="protein sequence ID" value="RCH98609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K911"/>
    <dbReference type="STRING" id="86630.A0A367K911"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629096" description="GH18 domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="93"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH98609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="460" mass="51074" checksum="29E9A8B7C70FD3CE" modified="2018-11-07" version="1">MRNLLFILIALCVLFTYTASAASHTKGHSKHKSVAHHHNKHSPKKHHTPAHHSTGKKKTTKKVTKKTSKKGSKKSTTKKTPTTHAHQKAYPKHKIVAYVLDWDTPKNIAWNKLDHIVYAFAEPNAKGDLKNFDGNNLKKLVTEAHKHNVGVSISVAGWSGSIHMSSLVADANRETFASKIVALVDKYNLDGVNLDWEFPNSPDSIACSERNPKDTANYLALFQSLRKKLDAKYPKIHKVLTVAAPVGPFNDENGRSIGRFDPAWATTVDYFYLMSYEYNGSWNDVAAPNAAIRGSSHGWGVDTTVNLWANVGIPKNKMHIGLAFYGKALKTAQPITEISGMYVKLDGHTPIQGDKYDELAADPCPGAKPGYTGEFQYRSIVAQGIQQNKNGWKSYWDEQSQTPYAFHAADSKFLTFDNPKSIQAKMEYAKSEGLAGCMIWSLEMDDSKHSLLNAVQSARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K973</accession>
    <name>A0A367K973_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NAD(+) kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_015143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000175">
        <property type="protein sequence ID" value="RCH98735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K973"/>
    <dbReference type="STRING" id="86630.A0A367K973"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="67073" checksum="89B253C90B1E6538" modified="2018-11-07" version="1">MESLSNIPCSALTDALVALAHNTSPKRRSSVKTIPREQHTSYLTDTADAVREVAKKLGRTRVKWENPKTVMIITKPGDCSLIRMTRDMALHLIETPRYGMDSGITVFVDQKLKESKRFKYEKIIKNHPLTVDKLKFWTPELCALNPKLFDFIITVLFSSWLFQTYIPPVIPFHLGSLGFLTPFDFGRYKEHLHKAMEMGVRINLRGRLTCTVYRRVPHPNCKSPEDAKVVHLRNVVRNPVTGKFTVGGWCQKQQHDGSGKKKKFGEVDGEDIEDEQAQCDPTPMGEERQVPCFTTVPVEKYHVINDLVVDRGPSPYVSQLELFGDDKHLTTVQADGLAISTPTGSTAYSLSAGGSLTHPEIQAILITPICPHTLSFRPTLVPESMELRICVPFNSRNTAWASFDGRGRVELKQGDHIKVTASKYPFPTVCKEDQATDWFNSLQNCLHWNKRERQKSFAVVESHGERKGLANSRASSIQQLNTLPNRHMADLSPTESQNGRKSSSSSLSDAGYDEVFGMFYDDEIHRRSESNSSINDDVDEFASDSDSEDDVVFNGWSDEEIIKSRYMANISKELEKVNKHIFASDEISERSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9V8</accession>
    <name>A0A367K9V8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative electron transfer flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CIR1_3</name>
        <name evidence="11" type="ORF">CU097_010686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000152">
        <property type="protein sequence ID" value="RCH99023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9V8"/>
    <dbReference type="STRING" id="86630.A0A367K9V8"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="45848" checksum="1A0D3D8739B9665B" modified="2018-11-07" version="1">MMEALTPVKSPTLPKKMETVSATECANCGTTTTPLWRRGPNGETICNACGLYLKARNTLRPPSLKRTNKKEKAVNDCGGGTCPGGGQCNGTGGSSSCAGCPAFNQHQVNRQALICANCRTTTTPLWRRDEAGNTICNACGLYYKLHNVHRPVSMKRSVIKRRKRIIITQGSDAEEDDDSESNIPEDENNDIKRFKKNAEVPEIEDYVVKKKTPTDTNIDRINFTPPMEDTHRDTASTLLPFEQLRNQEFNNNNNNNNNNNMDRSSSLLPPISSERKSYKLESLFHRESSTNALPSISLPPLSSSPPLPPSSTPQQNKSQHHQQQHRLTMSLSPPLPPSIHRQPLSVRSPSPMEQRRYELAEFDMALDKLEHLRRQVRPEQAYALSQLTNALTDLATKAEVILSLDSLSYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9Z5</accession>
    <name>A0A367K9Z5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_010371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000156">
        <property type="protein sequence ID" value="RCH98970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9Z5"/>
    <dbReference type="STRING" id="86630.A0A367K9Z5"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="527"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="693" mass="78241" checksum="3A643DDF02937EAB" modified="2018-11-07" version="1">MPPKQKKPNTSTEEDGKESFQAVILTDTFEEQFLPISHEIPRCLMPICNIPAIEYTLEVLAAADIFEVFIVCTSHIDAIKSYFDNSDRTRSKLSIQIVAAPECLSVGDALRELDARQLITTDFVLTTSELVSNMKLDEALEEHRARRKKDKNSIMTMILKEASRTHTSRAKDASSVFVLDPRTDQCVYYEPVVSLPRKKRIEMSPEVFENRTQIELRNDLVDPYFDICSVEVPPLFSENFDWQKLRSDFVHGILTSDILGKTIYTKIVSEPYLARVQNEKLYSTISKHILNRWAFPIVPETNLKEGDDYEFSRGNIYKARNVKLSRSCIIDDNVQIGSGTIIGENSRIANSVIGKNCVIGDNAVVEGAFLWDNVTIESNCHVRQSIITNNAVILENTSIDQGCLISLNVKVGPDMNIQKYSRLSLLPQPKTSMFEESSEEEDEDEEHHHTLTGSNGESIYFWTLRADDDEDTDIRNVKLGSLAYNMADIALKDGDLTESASEVGESEDSDSDMDTMGGAWGLEPNMAKKTEEFKKEIAQTIERSINEGHTVDTAALEVTGLRMSSNGSYTDVREVIVPIILDHIDANSPVQSLKTVFSKWSALIGKMTHSPDDQLHVLQILQRYCATKEHLNKIFLGALQLLYDSDVVEEDAIRAWYNSESSRSNPLESKLRDRATKFIEWLDEAEEEDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAI6</accession>
    <name>A0A367KAI6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ATG13_2</name>
        <name evidence="6" type="ORF">CU097_014807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000166">
        <property type="protein sequence ID" value="RCH98851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAI6"/>
    <dbReference type="STRING" id="86630.A0A367KAI6"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="373" mass="42679" checksum="7E1EDB38CCED9AD8" modified="2018-11-07" version="1">MQSSSNNFNQPTGSNVPTASTSSTRNSKLEQIIQNFYTKTAQIIVQGRLTASNTKRTSIRGYGSSVRKWNKWFNIATEDIELLREDLKYWRNLTVMDNEEQVPPMTIDIYLDTSKLTPNQTLMAVDDNLRWGYVDVLHVNRILIETWVLTLKYPPPSDYAVDLPNLYKRSIVFFRSLHSFVRLLPTYDLYRKIRKLNEANPLSIGYRLSSNPKAQYNSEISLDSTILESDARKPTSHYEFSDIVTPMGTFNLTVIYRRNCDFKVEDRERDLSAQFIDMDEQFFTPTMTKYQEEYSKARPTSLYSVTPKESTSTSSSTRGVSKESTYRPKSSSSLSSSTRRSSAPFAVSPFKSPFLSSSPQTDSICKKGKKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB13</accession>
    <name>A0A367KB13_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000130">
        <property type="protein sequence ID" value="RCH99330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB13"/>
    <dbReference type="OrthoDB" id="2284177at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8186" checksum="D1C07E31842F7297" modified="2018-11-07" version="1">MTSVDPIVTSFLVGYGAAAGHAEDEIDGLGLVGMVQPSAEFSSDAYDIDTLIKYFILHDPRTFRNYSNLGYCLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBE9</accession>
    <name>A0A367KBE9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="5 13">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HPRT1_2</name>
        <name evidence="15" type="ORF">CU097_015044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="PJQL01000116">
        <property type="protein sequence ID" value="RCH99544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBE9"/>
    <dbReference type="STRING" id="86630.A0A367KBE9"/>
    <dbReference type="OrthoDB" id="9449045at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000053">
        <property type="entry name" value="Hypoxanthine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="43"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH99544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="219" mass="24917" checksum="D70344C06198C182" modified="2018-11-07" version="1">MPMDPKDWIDVTTEKNHYSLNHFVIPHHYEKDLSSILIPHGVIMDRVNKLARLIVAETTGPLVVCCILKGGHQYFADLINAVKKLTNKEGKTVPLSLEFLRVKSYKNDTSEGVTMSITDEECRDFKGKNLLIVEDIIDTGNTMVHLLKKLETYQPKSIRVTSLLIKKTPKSNGYVPDYVGFSIPDEFVVGYALDYNEYFRDLDHICVISEHGKQAYAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBK8</accession>
    <name>A0A367KBK8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000111">
        <property type="protein sequence ID" value="RCH99612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBK8"/>
    <dbReference type="STRING" id="86630.A0A367KBK8"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="137"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="336"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="429" mass="48091" checksum="A6474177ED7A9CB2" modified="2018-11-07" version="1">MATGLEDKNLGRRLSHRASSVIVASEIIPPPVHFESFRISDDQLKTIKDKKIRKFYERQNSMISRFIHVDKIINSLEKGELSLPHNYGSILADEERGFVCAAAGESQPLLSSSRSTTPDVDNDKKSPMWIVHLAINLSFFANIALFLTKIILAWFSGSMALLASAFESFLDIVSNAIIFFTVRIIRQKDYYSYPVGKSRMEPLGIVVFAVVITTSFSQVLITSVEKLTSGSASEEIDLSLNALIVLGVNVLVKAVLWIWCVSIKGSSSVEALAYDHENDVVFTIASTLFPLVGNWLGWIWLDPLGAILLSIYIIYEWMNVLLENIRRLTGQAASADDIKQLTYMAYRFSKKITAVDTVRAYYIGDRLLVEIDIILPPDCPLREAHDIGEALQDALELMENVERAFVHLDYSAEHEIEHRRVVDGVGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBS9</accession>
    <name>A0A367KBS9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000108">
        <property type="protein sequence ID" value="RCH99665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBS9"/>
    <dbReference type="STRING" id="86630.A0A367KBS9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="348" mass="38076" checksum="E351E5410B046978" modified="2018-11-07" version="1">MSKNDTFTGWASVGKDKPLVQMQFPLKAWDDNCVEIDITHCGICASDVHTIDSGWGPTDYPCVAGHEIAGVVTRVGKNVTRVKVGDRAGLGPVCGSCKQCHTCSNGEENVCMDGIVLTYNSHWSTGEKTYGGYADKWRGDETFVCKIPDNVSNENASSFMCGGVTTYAPLRRWKVGPGSTLGVLGIGGLGHFAVMFGKALGATVIALSSSNRKRDDAMKLGCDDYVVTSNEEEMAKYANKLTHIICTGVGEDFKWETYFNLLLPNGIFINVNAPEFSYPPIPLFNQIFKQIAIVASAGGSVKDTEDMLQLISEKNLKAWYKKYPMSEVNKAIEDFRAGLPRFRFVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCB2</accession>
    <name>A0A367KCB2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_013033</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000103">
        <property type="protein sequence ID" value="RCH99739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KCB2"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 N-terminal" evidence="11">
        <location>
            <begin position="463"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="12">
        <location>
            <begin position="725"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="15">
        <location>
            <begin position="1392"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="13">
        <location>
            <begin position="1642"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH99739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1720" mass="196108" checksum="4E60B354064B0021" modified="2018-11-07" version="1">MRIQVTSPVDQSIVYEVDCLSQEQVDDAVQQSQTAFLEWKKVPVAKRVAIMEKFCTLFEQKKDLVASSITKQMGRPIRYGHGEVKGVLERAKYMISVAEESLKDTIIEHVPGVVKRFQRKEPLGPVFIIAAWNYPYLTTVNNVIPALLAGNTVLLKQSPQTPQCADIFVDTLREAGVPHHAIQAIHVQDKEANYLVQHPLVQYVNFTGSVAVGKQIRRAIGDCEHLIGCGMELGGKDPAYVLPDTNLDFAVENIVDGAFFNSGQCCCSIERCYVHESIYDAFVQKAVALTKNYVLGDPSKQETTLGPMANLRFANTVREHIKDAIEKGAKPLIETFPADKPGTAYVGPQILVNVNHDMLVMTEETFGPVLPIMKVFSDEEAIRLMNDSKYGLTASIWTTNEEKAIEIGDQIETGTWFMNRCDYIDPALAWVGAKDSGLGFSMSKQGFGQFTRPKSYHLKLSQHERYPMCSELITDNGIPEFDNLYLDMNGIVHNCSHNNSDDPHFRITEEQIWLGIFQYIEHLFSKIKPKKLFFMAIDGVAPRAKMNQQRSRRFRTAKDAEDARRKAIQNGEELPPEPPFDTNCITPGTSFMIKLTQQLRYFISKKVQEDANWRNVEIVLSGPEVPGEGEHKIMEYIRLSKAQPDYDPNTRHCLYGLDADLLMLGLLSHDPHFALLREEVVFGKHQKKKVANVENQNFYLLHLCLMREYLDMEFSALKNTLSFGYDFERILDDFILLALFIGNDFLPNLPNLHINEGALGLIFKVYKEVLPTCGGYLQDGGHVEFSRLQKVLDQISAVVEKEAFEAENIDALYLAGKLPDGDNARELLHEIERKKATDRLSITEHQAEIFGKIRDFLVTPPKLNTESTLHFAFPLKSRDKKFLDKLTKELNMSYVYAWSQSHQMTEVELSFTHNLYADDTDDSPSTTSEESDVDEEAIAARDRVLKKYENAEIIPEEVSREQIEREEKAKFEAAFKQWKADYYKEKMDIDIDNQEQMDKLVSSYIIGIQWVLQYYYNGVASWSWFYPYHYAPKISDLKDIARFQDYSFTLGQPFKPYEQLMGVLPALSRKLLPAAYQDLMTDPDSPIIDFYPSDFDTDMNGKKQDWEAIVRIPFIDEQRLLDAMKQRESRLTKEEREMARFGESYKFVYDETLAKGDPKTWPVFKSPLPGKFPDVRPCFVRETQYHLPVLSSHGLRKGLLPGAKLGKEALAGFPSLHTIAHDFHIANHGVRVFQQDSTNESVVVYIKNRFKNASLRELAKLFIYRTVYVGYPYLKEAVVIGVSNAECKYHVSLDSNGGKHFLEHKWNDRERDDWYNTVSRHDHIRSKRFGLLIGETDILAHVCLLKGMCQNEEGALVKQYDHPTLAETIPFQTIVIKVANPDPRFIEKPAPPIQVSHPVGSHCFFTSGILAGTKVKVIGHGPHGINVQATKVRNPRFEHEPRFGYAIVNKQEKEITYQPAHVVARELNISSLTLAKLTSSLQVVERTGQKLNIGLNLKFESRGEKVPGYTRKNPSAGYWEYSTLAVQLIKEYTTTFPEFIEMLNNKKDNLMMDVSDFGWTNEGYKYLHKMKEWIKERKVHDLPRAPHSTEELQSDYVLMIEEAAKEYQQRYDKESRSKFIVKNTPRKNLLRPSDAPYKLINQSFALGDRVIYVTDTGAVPLGLKGTVVGVLDKVIDVVFDATFLGGTTLGGRCKETRGASLSYWQVYNLSGSSERSHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD97</accession>
    <name>A0A367KD97_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">OPI3</name>
        <name evidence="19" type="ORF">CU097_015241</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="PJQL01000076">
        <property type="protein sequence ID" value="RCI00176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD97"/>
    <dbReference type="STRING" id="86630.A0A367KD97"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="17">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI00176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="21954" checksum="EE971D79C83F701A" modified="2018-11-07" version="1">MYNDWIDFSQPSLYFALAHILFNPIFWNTVARAEYNSKILTKLAGGNAYRGCYGLAVTIFTLGITRDYLYHQALSFQPTHSFFDNQIVQLSAILLFLTGNTLVLSSMWALGVTGTYLGDYFGILMKERVTGFPFNICDNPMYIGSTCTFLATALWYKSPAGILLTVIVYIVYKIALTFEEPFTAMIYANKDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE82</accession>
    <name>A0A367KE82_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">U2AF2</name>
        <name evidence="11" type="ORF">CU097_001732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000061">
        <property type="protein sequence ID" value="RCI00420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE82"/>
    <dbReference type="STRING" id="86630.A0A367KE82"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000676">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="217"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="325"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="435"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI00420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="533" mass="61457" checksum="0F5C377194E8DB95" modified="2018-11-07" version="1">MSYGWNRDQSHPSQQSAADLANSFLSSVGQELHGSGDNHYGHESQGRYGDYHAEDYRRRDDREMDRERRRHSSRERYHDRSRDDRDRDRDRERRRRSRDRRERSPRRHRREERDYHRRRRSISPRRHSRRRSISPIRRRDDENIVPLSKRPRRLHNWDMAPAGMEGMTAQQVKMTGLFPLPGQVVGTRTPQSFQPPPVNHKFDDRAIVNTALTKQAKRLYVGQIPLGLEENALADFFNATMHQLKMRDRTPVVSVQINHEKNYAFVEFETAEQATACMSFDGIMFQGQQLKIRRPKDYQPAPEVVDSSSLQLPGVISTNVPDTPNKIFIGGLPIYLNDDQVIELLKSFGELRAFNLVKDATTGANKGFAFCEYADPSVTDLACQGLNNMELGDRKLIVQRASVGAKHIPPDYMSGPILPANYVPVTSARDEDATRVLQLMNMVSPEELEDDEEYQDIWEDIAEECAKYGNIIDMKIPRPHEGKLVPGCGLIFVRYETKDETLNALRALAGRKFADRTVVASFIEEENYLADNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFY5</accession>
    <name>A0A367KFY5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000027">
        <property type="protein sequence ID" value="RCI01051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFY5"/>
    <dbReference type="STRING" id="86630.A0A367KFY5"/>
    <dbReference type="OrthoDB" id="429183at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="58"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25545" checksum="84E7F82144D70817" modified="2018-11-07" version="1">MPGEEDDQTHLFAATDDQQTSGLLSMTSRTQHRLTKSEIVKGMANRFMYSKFYIGLYLILAFLSFVSIIMSLTETCPSHLFIIFEAIINLAMIVEVSTRLLALGRNYWKSVWNVVDIILVMLCVVTLIVLTTGCSIGERNEAIFDTILLVIRNGFQLFRLFMMLRRNQYSIRARSTRIDFDDILDSAEDPSNDFNIEDRDRNLQESFLDDDDGDSDLERSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGS9</accession>
    <name>A0A367KGS9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000027">
        <property type="protein sequence ID" value="RCI01052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGS9"/>
    <dbReference type="STRING" id="86630.A0A367KGS9"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="605" mass="67182" checksum="2CD224372F128548" modified="2018-11-07" version="1">MKMDNNKHTAEVIESGTTHRALSPSKPMDDPIEPLPSDSAQLTPSETTRISRKDSLSQEKRKWDESFTVAEKKELEGNIVKAAKDNDGETYVTLQKEEFTVSSLNDEEEDYSQESDSSINKRPGRKPMPDEELSDSEQDPKIKRKAQNRAAQRAFRERKERYVKELEAKLKQVQDTHLVATAQLIRENHQLRSIIYRLEAENHALKGTQIPYSSPLSAIPHSIGLSPSSPTSFQQHHQRHHSTGSSTQPYPSIAPLLPSSVVSAPHTPFLLSAYLSPGSPLASSPIVNNAMLLASAPLHQYPLSPVIANAGQSISPQPAPTSQTKPHSPKKSTRQKLSSPPLNNQPLEYTFSISTPASLRPSNGPKQVNKVEAIEPVQLYPPDNLPPSAKHETSRRTELSPSPIVKKANSVISVGSQSSSSTGIAFTPNYAGAADDDSIFSDDKSTSTSNTQRRNMRQLELDMLGCHIDVEGQAFCKRLCDEVCNDAFDRLLSEPLFDQMGKLNLSISNYPVPFVTDPIPNDEEGKEPAQRSKDKEIIERIKDNTRLYTAPEIWSKLTQHARFQEFTTDQLYQAVKDVAKCSEIGPVLKEDDIQHVMSRMDQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHA9</accession>
    <name>A0A367KHA9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000003">
        <property type="protein sequence ID" value="RCI01604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHA9"/>
    <dbReference type="STRING" id="86630.A0A367KHA9"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="303"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="42528" checksum="CEAC186BBE1DF03A" modified="2018-11-07" version="1">MTVHGINKKFTRRAQRLKQATGFAVEPTHDILFEALHTKFEEQQENIRQLARDVQGWVRHIKIMFDNLHQLACSFDTFYSSWGGVRVKSMSNIQEFSKMASHLSASLSRELDNDVRGFVYSRIDEFLKVFENPAQVIHKRSLKMIDYDRVRDMKSKGDIPDKALQESADAYVSINAQLVEELPKFFELTAKYFDILVGGLAHVQTKFYKLMQREWTKLVEQHLGEKAASGYTEIITKYMQQYERLQVIADQIDILHPDRYVTRTESSSSFDQRSLRSLHSLNSTASNKVYTSQPSFTSQENSPHDFECVVLYDYQPYEKDKLNVKRGDILVVHQDDDHLDPDWWYGTVKDSNSSGWVPINYCQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHT2</accession>
    <name>A0A367KHT2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 223</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000011">
        <property type="protein sequence ID" value="RCI01412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHT2"/>
    <dbReference type="OrthoDB" id="5950063at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026100">
        <property type="entry name" value="Tmem223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24110" checksum="5783221B59BB8216" modified="2018-11-07" version="1">MPPIRQTQAYSTKTVFDKQSIQFLSKHLKQALQKKDVVFYQAPPGVKRTFNWMYISAGVQLMFWGNLASLAYVAYAVKDGDTEDAPVVLAPQGKRIAIAGGLVGIGVAIATVMCLYPWRYIDKLILLKGGTTVRLMTHARFAKSHQVKEYPIDQLYCKQKVFTGVGKNGTDAIGTKSSSSHIFLNAKGEKMAYMLDRKGAFMDSKLFDGLWYNSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KI05</accession>
    <name>A0A367KI05_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000008">
        <property type="protein sequence ID" value="RCI01482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KI05"/>
    <dbReference type="STRING" id="86630.A0A367KI05"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="680" mass="77329" checksum="47B010AC15B09127" modified="2018-11-07" version="1">MTEKASTTVGRASSVKRKSILSELGIKPGAEPVSSKPTTRTSPTSTASKTKTATRTSTVPSATRPSKTPVTRKAPPAAIKTDRATPTSSATSSPTVPKRRSIVPSSTASNRPPNSPLARRSSVNHSPSTSNAAKRMSTPVGLAELTIKEKVPEQEELLEQKEKEIENLKQEHKQNVSKLQEEIDELKKQLESNKAKDVAESNDKDLIEKAIQEAKAKLKQEHQEEMEKVLEEQEKKLRSEMAITKAEYEEKINMVQSKQADITKQLDFIKAENIELKAQLQKEKDEHKENNDRHASEIAELNEKIASLEKSHTNSHIRKVESELANAKSALEEFKRQSQLHIEAIEQRHREEIRQLQSGTDDTAMAWLEKTKATQQEVHALHDELQRKEAAHNESLAAVKEQYENEIELLKQTCDKKETEIEERSAQIESLLFQVETLQNSLEAATARFEHTAKSTPSSSSNPDDINAKSHNTSHEQCVKRYEAKQKELDDLKVRLAEIKETHESQLNRLGQEKANAIQELRKTIAQLEQQQKSSGSGNVSEERLIQIAEQHKKEIQAMHEQYQHTIDAKNKELEDYAYRVKALVASKQKELEKLQIEKKMEEEKHDREVEGYEIKMKELEKQIYKCQERANHWEILHNNSQALIEDMKKGCLAHRDENEQLIKLANRLQLELQKGGAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILX3</accession>
    <name>A0A367ILX3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAP kinase kinase (MEK)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">STE7_3</name>
        <name evidence="7" type="ORF">CU097_001972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004995">
        <property type="protein sequence ID" value="RCH78669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILX3"/>
    <dbReference type="STRING" id="86630.A0A367ILX3"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH78669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="150" mass="16804" checksum="DEEF264CC3DA5F8E" modified="2018-11-07" version="1" fragment="single">SLDQIYKKHGPFPLDVLKKVGYAIVDGLIYLYDEHRIIHRDLKPSNVLVNSQGQIKLCDFGVSGQLINSVADTFVGTSSYMSPERIMGSPYSVKSDVWSLGITLMELALGRFPFPPEGTPLSIFELLQHIVHEPVPTFPPNKYPQDLTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IM90</accession>
    <name>A0A367IM90_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIN1-type PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004916">
        <property type="protein sequence ID" value="RCH78788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IM90"/>
    <dbReference type="STRING" id="86630.A0A367IM90"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIN1-type PH" evidence="1">
        <location>
            <begin position="76"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="163" mass="18782" checksum="2AEF492008550AD8" modified="2018-11-07" version="1" fragment="single">TNVIVPNDTTVESMKEITDLTLVKKERTLTIPSTNHLWRSPIKRKKDEVTHPMYFSDVNQRPTAANANDGIFSQYKQKYSVSRKMPMFVSKKVYILAIDGDYIHLMPPEHKGMFDSVKTTSFHASAIRSCKQSKKVPSNFKIIVFKERDYKTYDLEAESSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INX4</accession>
    <name>A0A367INX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">18S rRNA pseudouridine methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_000034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004532">
        <property type="protein sequence ID" value="RCH79387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INX4"/>
    <dbReference type="STRING" id="86630.A0A367INX4"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH79387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25954" checksum="6C9BC0AB3C27B930" modified="2018-11-07" version="1">MAEDSSWHEAPTQDQAVVQRSRKVVVVLENASLEAARLNFFRSDSKMQLLNCDEHQSILKKLGRDIADARPDIVHQCLLTLLDSPLNKSGHLEVYIHTAKGVVIRINPACRIPRTIKRFSGLMVQLLERGSIKGDVEGNITLLEIVPGPVQQYFPADSKVLALSYNAPRVKLYDYFKQLPKGQPVVVAVGAMAKGPDTFADAYAQEKIGISQYALSASVACGKVCCAFEDLWDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS80</accession>
    <name>A0A367IS80_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003876">
        <property type="protein sequence ID" value="RCH80512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS80"/>
    <dbReference type="OrthoDB" id="273230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="14824" checksum="2974EF26A50194E8" modified="2018-11-07" version="1">MTSFLSNKLFKKTKRNTKVLWLSFCKSSSYSFQEISFQDKDIRAFEKSFQIAADEMVYAIESQGSIYYRGDFLAASEAVHLCIDQFHDLLHSLKPDKSHTFQLKWSEPLFKLRSRLDSLPSPKDKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU39</accession>
    <name>A0A367IU39_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003531">
        <property type="protein sequence ID" value="RCH81215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU39"/>
    <dbReference type="STRING" id="86630.A0A367IU39"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51805" checksum="8962C33CF9E05F57" modified="2018-11-07" version="1">MKHTESLKRYNKLGEWNEYQRIPLKEHEEWIQIYQNIEDYLPKTTVKVEHENTLHNLEAHNRLRTSNNSFIINHGGSIWAMDFVPKKRSSRDAEYLAIGGYKTTEEHHALGEVSCYKNAICIWKYDSDHEPTLDMCLLGEFGIIADMKWCPLSSYGPKLGILAVLVGDGSVYILVVPHPDHIRKQGHPSDETLYLKIKKPRFVLKSPRAYYLCMSWSSQFLACGSISGSIVIWDIFQSLCRDVPIVHVQLMMTAPIRSVSWTFLFDSLLLSTDTAGRVYLHDMRDPFMSQQVMKIKSPLIPVLGAEHLAHSFFYGDPEGNCRLNMSFCSKQSTALLSSGHGQIWSIAFCRFCELVASASSSGIVMFRYCTDSVGQPLRHKGRADGNLLYRLCFDGDVYRYLNKTNESRDFHHVLLNPNVSLHKVVWNPNSMACGWIASGGKAGLCRLEFVPSGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUH8</accession>
    <name>A0A367IUH8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cux N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003485">
        <property type="protein sequence ID" value="RCH81327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUH8"/>
    <dbReference type="STRING" id="86630.A0A367IUH8"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="185" mass="21432" checksum="94F2B1718D4BD5B5" modified="2018-11-07" version="1" fragment="single">MSVDTFSSAIDYWKKIQLSNLQKELDQQGLTIVENQKDGLVSRKRLAEQTREFKKIPDEEKLQKIKPLLKAYQAEIDNITKRTKFSESSFLSIYKLLADAPDPAPLFEAAIDQSAKIVDNSVLQNENSLLKEQLDKANKQLADLERTNTELAQKVSSLNEKRDANTIEQEIRDQYNDRIRQYKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUK6</accession>
    <name>A0A367IUK6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003469">
        <property type="protein sequence ID" value="RCH81364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUK6"/>
    <dbReference type="OrthoDB" id="2275406at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="10284" checksum="32334645D552A84F" modified="2018-11-07" version="1" fragment="single">MTCGLSSILDLDSNEIESSQKHLFTEEAWESIFTKYNSCKWKLPPFPNKLKQVWDTIINICSNENDSSNAKKFLYKMKLNESTSKDQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX89</accession>
    <name>A0A367IX89_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CU097_002995</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01003063">
        <property type="protein sequence ID" value="RCH82310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX89"/>
    <dbReference type="STRING" id="86630.A0A367IX89"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="60"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="394"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH82310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="588" mass="62576" checksum="679BB480A938EA4F" modified="2018-11-07" version="1">MANTSTGEVYIHKLEPRNRHVSAEAGVLNKYSRTITQIPSAGAAQAQLYATGLTDEDMNKAQVGVTSFGYDGNPCNKHINDLAAKVVQGVWDAGLVGYQFNTIGVSDAIPMGSAGMSFSLPSRDVIADSIETVMSALWYDANISIPGCDKNMPGCVMAVARLNRPSLIIYGGTMKKGRGTVGSCKDREIDIGNALECNGEFISGKITEEERKDIIRHACPGAGACGGMFTANTMSSAIEALGMSLPYSSSIPAEDPAKIQECLRAGQAIRGLLEKDIKPRDIMTRKAFENALTLIMVLGGSTNAVLHMIAMAKAADVSLTIDDIQAISDKTPFLANLRPSGKYVMEDLHRVGGTPAVMKYLLENNMLHGDCLTVTGKTLAENLATVDGLKEGQDIIMPLSNPIKPTGHLTILRGNMAPEGAVAKITGKEGLEFTGIARVFDDEDDIFEALEKKAISKGSVVVIRYQGPKGGPGMPEMLKPTAAIMGAGLGKDVALVTDGRFSGASHGFIIGHVCPEAQVGGPIALVNDGDKITINAKTRELTVHVSDAELEKRRSLWKPKPPKYTKGVLAKYYRTVKSASEGAVTDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXY2</accession>
    <name>A0A367IXY2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FRS2</name>
        <name evidence="9" type="ORF">CU097_001369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002980">
        <property type="protein sequence ID" value="RCH82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXY2"/>
    <dbReference type="STRING" id="86630.A0A367IXY2"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PheRS DNA binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phenylalanyl-tRNA synthetase" evidence="7">
        <location>
            <begin position="207"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="31066" checksum="41C6E52AA3258C0C" modified="2018-11-07" version="1" fragment="single">MSTEELQTLVLNTLDQQTTIQDSKDLSFNGSPVDQLVLLGALSSLKSKNMVDFAPIERIVWSLTEEGQQLAKEGSHEARVFEAIPPGEEGLPIAELQAKFGPAAKAGQGKAFKNKWITKKGNNLVRAVDSIVDQTQKELQEIQSTGTLGNDKALAELKKRTLIDKQKLTTYSVSKGPEFSLEIKKEATDITVEMLQSGEWKNATFKKYNFDAAGVPPAGGHLHPLMKVRQEFREIFFEMGFQEMPTNCFAESSFWNFDALFQPQQHPARDAHDTFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYU3</accession>
    <name>A0A367IYU3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002868">
        <property type="protein sequence ID" value="RCH82854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYU3"/>
    <dbReference type="STRING" id="86630.A0A367IYU3"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="68"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="291"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="499" mass="57766" checksum="CFED52F5A40212A3" modified="2018-11-07" version="1" fragment="single">KQPPSLQSGRHPLVIRCRDFTMFTLGLLKEGEAQDVFDTIQKLACVSSVEQLYAYTFQPEAPFTTENGWNIYDPIKEYERMGIGASDKWRFTVINRDYKYSPTYPRILVVPSKISDAVLTHAAKYRSKARIPTLSYLHWYNNATITRSSQPLVGFKQARSIQDEKLIESIFSSNVPTGPNGETVYGSTAANLIVDARPMANAVGNVARGAGTENMDHYRNCKKIYVAIDNIHVMRDSLAKLCEAMQGVNNIVNKVALQKSGWLKHISTLIDGTREIVKSVHVYNSHVLVHCSDGWDRTSQMVSLSELCLDPYYRTFEGFQVLIEKDWVSFGHKFQDRCGHLTNERFFINNNDNTTASSFRDKFYYNNHQKETSPIFHQFLDCVYQLLCLYPTRFEFNQELLLELHYHLYSCQFGTFLFNSEQERNQYKPQDKTFSIWDYLNTHKSRFMNEFYDPMKDKDLVDDGGVLLPDSTRVKYWATLFKRNDDEVNSVMSPENTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ51</accession>
    <name>A0A367IZ51_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002912">
        <property type="protein sequence ID" value="RCH82741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ51"/>
    <dbReference type="STRING" id="86630.A0A367IZ51"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="322" mass="36225" checksum="7C1C1C6E6967C137" modified="2018-11-07" version="1">MGSCFAKPWLTECANKNRNREKYFSTAMSESRQTPCISCSEDITIPTQREFHQIEASTYWLPKDDEEQMRLTGQHFALKEIFGGNVLQSATEILDLKQGLSILDVGCGSGVWVMDMINDYPDCNYEGCDMVNIVAQKPTPKQFTFRIANVLEGLPYPDNTFDLVHLRLLVLALRYDEWPGVIKELLRVTKPGGLIQMMEPDYRVAEHDDTFCKVVSGLITICEAKGQNPRIGIELERLLREAGNTKIIETKSAFVDTTTGSSAAKKIAWSWMEGVKGVMKVGAPVLGLKDEKGQQRFLKEFKHCMETKCGCLHMEAVVAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZK1</accession>
    <name>A0A367IZK1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_002431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01002768">
        <property type="protein sequence ID" value="RCH83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZK1"/>
    <dbReference type="STRING" id="86630.A0A367IZK1"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="24788" checksum="53FECF6CC02FF9FB" modified="2018-11-07" version="1">MAKPSPIASKVAGIILPFVVFGLLAYSWVSGCVGFGNYKFFFLFTSYTGIYGLWVFVTTLPLVVRGLQDMNADLDPQWIVLIILAFVFGFTVLGFTGVHLTYILRNETTIEHLADRPYDIRVDFDASGDNFEVVTVEPEHYLWERSRKENWESVMGNSIVGWFLPFKRGLGNGFVFPYSDRMYHEIVQRAQRQRNSMNLSHYERVSSSLESTVPITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0B0</accession>
    <name>A0A367J0B0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002684">
        <property type="protein sequence ID" value="RCH83375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0B0"/>
    <dbReference type="OrthoDB" id="2280749at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="95" mass="10610" checksum="A8D3463A9172647C" modified="2018-11-07" version="1" fragment="single">NNGSDDDYHLGVDNSSQLEPSSPSPEAGIQLKERIRVDFVLFVNDQEVGCGEIKSPGTTSQLLEEDWARTAETLKRQLPVCIMKSKDTKEFKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J111</accession>
    <name>A0A367J111_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002602">
        <property type="protein sequence ID" value="RCH83628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J111"/>
    <dbReference type="STRING" id="86630.A0A367J111"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="260" mass="28249" checksum="ECEFC3712EF322E5" modified="2018-11-07" version="1" fragment="single">MKAATRRKVSYVVKLRTDEQTHCLGVNSLALDASRCDIKDDTAEGGVLYSAGRDGVVASWDLNIRFKRQLNTEEAWLVDKQLQSAGKSTCKAFSQIHTDWVNDIVLCQEGTCVVSASSDRTIKAWRPYSENSKTVHTIGTHTDYAKCLTYASQPGWVASGGLDKKINIWDISQSKAVVSIDAGPSNHYADGTNESSTLHNSASKCSIYALAANAPGTIIASGSPEKVIRLWDPRSGKRIGKLTGHTDNIRALLVSQDGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1R5</accession>
    <name>A0A367J1R5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Little elongation complex subunit 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002527">
        <property type="protein sequence ID" value="RCH83884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1R5"/>
    <dbReference type="STRING" id="86630.A0A367J1R5"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019535">
        <property type="entry name" value="ICE2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14633">
        <property type="entry name" value="LITTLE ELONGATION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14633:SF3">
        <property type="entry name" value="LITTLE ELONGATION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10505">
        <property type="entry name" value="NARG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Little elongation complex subunit 2 C-terminal" evidence="2">
        <location>
            <begin position="459"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="658" mass="76111" checksum="82CE9DC82E377DFA" modified="2018-11-07" version="1" fragment="single">DQEDVQSIIDIMERTSSNENDGETESDDYFGSEDGTDTQSIRHETENEEILAPDTLKTSDREILSLSAGQQEVRNENLNASGIFFTQEAYEAYTISYNLVPELHGLLQSAILSRREFECSNEEANDPSPSEHVFTPGENISSEPEDQSEPEPVLQTPNLLDTVLNNLEQYQSDSNNTQQGVSDLEIAAQFADLNDNTDTKETKDNQYSKLTRQQHKQFISLSDQIKKEEYVNHQRKRMLASKVYDILDNKVDTMIKEYYALENKRIQKYPRFYRCFNFVKMPVAIPQEKPILSFKKSLLKSGQICACKPEVFESPRRMDIFKHYIDTGKAYEDDIAYGTYYKKKMPPNLSDDRIVHDIIKHTRFEVVISSSSLLKLVEIQNDLSTSTYIPLTVKQENDYKTLIFDRPLPKEALTKREMNKIVYDLAFKSLCLDWAKRHPISSTSKPNINSSDTEEWDYNNDENLQYNHWTFGEDLNILIRHQSDGELSNQNTTGTADKKVILVSKLDYQICEEREEVVTPAERAMNWLRSYIGGHSIVMEGRIDLVNNRLVRVDKKQMIDIMGDRWQPIGESELIRQTFLNLQKILEPGQYLLHHKPGDRNFLIYQSIDEQVNQNDSSIIDLHKKYGDNSPYPSDSANCFIPAWKSNEEQVAWTFPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2H5</accession>
    <name>A0A367J2H5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_001105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002514">
        <property type="protein sequence ID" value="RCH83921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2H5"/>
    <dbReference type="STRING" id="86630.A0A367J2H5"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17720">
        <property type="entry name" value="BRCT_Bard1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="244"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38410" checksum="8EBEFA4CB2C66133" modified="2018-11-07" version="1" fragment="single">ATDQGIDALLESIIVENPEQEHDALIDKGDDAKNQTKDEANNSDTQWKCPDCQFDNPIYVQTCGVCRKPKNIPVIQSTGACSVPKTANANKGLEAQTYMPTVAADNEPESATIVPDKAQSTENNKRKEVHVMYTGLASEDEETLSKLVNSKRDTKLKIFVHFKTRDFHDVTHIITSVDNKRLCKRTFKYLQGVLEGKWIVTPAWLIDSIHADRWLPEDAYEVKGDHVTGITQAPIKGRERVQQDKEPLFNGMKFYFFGDFTGKHSKNDLLLLCRAGGGKILNRKPNGLGQRVDPDIDPLDRNEPIVIMCTGKKKPTNQWLYESQVRDPSWIIECISKLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2M1</accession>
    <name>A0A367J2M1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002498">
        <property type="protein sequence ID" value="RCH83971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2M1"/>
    <dbReference type="STRING" id="86630.A0A367J2M1"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="86"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="544"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="684" mass="78401" checksum="40115F4D3F7B287B" modified="2018-11-07" version="1">MSLTCQSPTQHWSSENELVISCSTNSDNDSISHKHCPPQEFMNALYAKRHHLNPTTGHHHHQQHKDVLKPISSHELNRLLNTTIPLIIDVRAITHFSTRHIKSAINMTMPSILLKRASYTLDKVAQSLANDADADHFRQWPLASHIIFYDHASVSTTDSGNSATAILLALKFKNANYQGQLNYLKDGFNQFQRLYPDQCKQNPATTTNNNNEKPTAETPFFVNIRQNIELPQGQIQERFTIRIPYGKRLDHGVIHLSASPTHHPRYGLGGSSVDTQGNFELPIWLKRIMDKDNGPKRLAEAYEQLERTEQKRLSFVLKYHSAHKSTEFPLSIASAIEKGTLNRYNNIWPYEYSRVKLLDKKDDYINASYIQYAVRKNDALLRSVTPLSKVDQDLIQSGIISQDALETMRNPDVLDKNRKYIATQGPLPTTFNDFWKMIWDESSYVIVMLTNEEELNKIKCHRYWPSTVGVSQNYGPITVTMISEQAQPVMNMNDKRERSEEDLIIIRKFHLKHRSSLLQDRTITHLQYTGWSDFGVPDHPIGLLQLIHVADEAYKIEHQAKGPMTVHCSAGCGRTGTFCVVDTIIQRLWHERDVYTNTMTDKVQEAVSRFREQRMSIVQTQRQYVFCYEAILWWLLGYGHLPTTPNSPRGSFYLDEDGALADGEDNDDDDVNSVNGIVHTFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3E9</accession>
    <name>A0A367J3E9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002355">
        <property type="protein sequence ID" value="RCH84474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3E9"/>
    <dbReference type="STRING" id="86630.A0A367J3E9"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="59562" checksum="AEA9D060EB12B501" modified="2018-11-07" version="1">MNAHTFDMLIGPRKTKSVLGIVIASVTVIVLLKRVIGIRRGNASEFKNIPMPKGKFFYLGHIPVIAGNSGKAMIKWHDECGLVYRIKMGVQNWLFIGDPQMAHDIFVTNGSLTSNRPHSTFLTLLNGNRQSAILFAENEHWKYARTTLNTILSSRSIDSLSYALEDEIGQSIDLMIKDAQTLGEIDPMIYIRLTAMNVFLVLAFSISGARSVDDPLYIKMNHVVEKVVSFIDPALDISSMLPLWKFFDIFSSKKHQITEFLENDVKPFIRSIIERARTSEKDNFVKKLDEAKDQDKLDETHIVALITETLVAAIDTVSITTVWAVAYLCNHPKVQENMHQEIDTFVKKHGHIPSFTDRAELPYCFSFQKECLRFRPPGSVGIPHKVSKDIVYKDCVIPKDTLIVASHYILNRRADMLKNADQFIPERYIEDIRSFSACNKMHTTKCSIITFGFGRRICPGSYMAEREIFSMLVELLSKCTIKPILSSKGIPVYPNLDEYIDKCVMTPLAQFKVRLIKREKETAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4K0</accession>
    <name>A0A367J4K0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002244">
        <property type="protein sequence ID" value="RCH84872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4K0"/>
    <dbReference type="OrthoDB" id="2438256at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="264" mass="29923" checksum="D404395A2C10A5BB" modified="2018-11-07" version="1">MAAMNDNVYARVRDKMREQNFSEQEIEALDNARGLLKTYARIGGFMGATAAFLIGKSKKFKPFPLLMVAGGGFFLGSQTGFLTGVLSGINSIKSLPDPQRLINIMKEVQMEAARGNIQSSPVPQRPVVQETQNPMDSFSPDVPDYQQNEKEAWESTIPKSFHHDTGDTVMMDPSMKPEQEQPQQKSSWDKIREQNIPNSTWAKIRMEAQKNSTSADDIAKARAERAKRLRESSEFGQEELPRTREDYFEQKRAIRKNQFGDVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5E7</accession>
    <name>A0A367J5E7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002168">
        <property type="protein sequence ID" value="RCH85162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5E7"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="302"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="681" mass="77510" checksum="B00481F53F6DB06C" modified="2018-11-07" version="1">MLSWLMINNKRQNQKQHPIKRSQLKSEKSTLTSKLPASVKSTSVNVTISDCIYDKTSNATSLSLSIEKLNKPTQEFLQKPDVPIYQPSPLRLQSSKVAPITFSTSISANGNVIPYYDHDELIEHSPPTTAISYLTKEMEKNFEHYHNHHQLAESSSDTSTDLNRLKSSTLSKKIQDDHRLDRRDSSIDIASMNSYEQQLHKITKSKTYTIRLSPSNSSLRRQNNEVLPQFESLFTRQPSPQPAPYDSFIIRAINMVNSILIPKPTKQEDVSTSHWIAKKVREKFSSFVQDIKSLDPEKSFMDKRIVIIGVHGWFPMKLVRSMIGEPTGTSVKFCEQMAMAIKQYFKTEHQVTLPDHAITLVPLEGEGKVQDRVNLLYQRLVDNSRWLDAVSSADVIFWATHSQGTPVSVMLLKKLLERGHIHTFRQSICLLAMAGISQGPFPALKGSLIVKYFEADAARELFEFMDSNSPISMHYHQSLAYILKSNVKVVLTGSMQDQVVPLYSAVMSNLTHPNILRTIYIDGHFYSSGDFLIHLVVFALRLRNLGLSDHGLVTHLSEVLAGSIYVIEGGHSTIYEELNVYMTAVRYTFEVSPFGDYTRRNLMKPQEVATIEPFKAKQSSNPYYIPWAMRGICSDPSILAHEELKTELNSLFRLFEMWNPTSSKLKELKFKLDPLKNFTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6I0</accession>
    <name>A0A367J6I0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002082">
        <property type="protein sequence ID" value="RCH85505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6I0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="58" mass="6977" checksum="BF7E9693510FAFF8" modified="2018-11-07" version="1" fragment="single">MNYLIRFKPKSIHNLSVTTRCSHYIINRHISTEIQHQFEEELSETYVLHKKLSGARMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6K0</accession>
    <name>A0A367J6K0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002076">
        <property type="protein sequence ID" value="RCH85525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6K0"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="543" mass="60893" checksum="91C1E7EAF473FBDC" modified="2018-11-07" version="1">MDTIQLETTNSTPVMSTSIKPKVSTSTPILSNNRSNKDRKLKKIQSIQPSDNKNTTHANNLPSLNKKTLATALSLRSYNKPSIPIQKLKADVDTILLNKETTKYMNHKLVTTATDIYSQSNTNSSSGSLALSESGSSTTSTFNSNEIICDTSNVVGDTFTSQLCKTDFTKISSCDDEEKQSHTDDLETNVHPCEPVRSSDLNDLSEQPSVQPTASISSQIISSSRSLLRKSMHGNKFVSNNAKEEDKSKKRSVSLLRRSKSQRSVASSTNDVKASNKSTKNINPLPTLNTCKIDPTTFLAGPATPSSLTVQNKQFVLMYRILESMTCGGHVTGNLHIPMDLWYQTNVRLPYIEAKIAASELLIAVLEKMNARKNIELNMSAVINELKVLRQTLNQIDDTLMRKLGRPAPTVPLNNKQELGNIHRYSIRTSQTIITWSSRLSKSVEKMRFDTTRNTAPNDEQNELYIKTLMKLFTDAKVLERWDDTLTSIMHKAGKREGLVKEAYQINKTCITQFMTIVCGFVLKDYEILLNKWFKRSIYWLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J748</accession>
    <name>A0A367J748_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_008825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002028">
        <property type="protein sequence ID" value="RCH85730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J748"/>
    <dbReference type="STRING" id="86630.A0A367J748"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="464" mass="53143" checksum="67FC3C174879749D" modified="2018-11-07" version="1" fragment="single">YDAAIQYDPNDYISYYKRATAYLSLGKTNPAIDDFSKILTLKPGFKQALLERAKLYLADGEYKLAKQDLEGVSQDDSTKLLLSSISEAEKSSQIAQESFSHQQYDQCIQHATRVIQISPQRSQWRTLRAQCHFGKGEIEEAVNDLTRVSYLNPSDQELILQLAKLNFYSLYEPDRATAQVKQCLHYDPEHKPCKSLFRQIKRLQKDLQKVVDAKQQQRFATAFNTLVGTSTKKGLVSELDEPFNALKTEMKIENLPKRLHLTCYELACQLSAEQKDSERIDTWCSAVLKINPDHPDALTHLGELKLNNNDFEGAVHYLEKAYEANGQQDHRIRQLLNRAQQLLRQSKKRDYYKILDVSRDADPRTIKKAYRKKAYEWHPDKYSGNLDKDQVESKMAEINQAYEVLSDPAKREQFDNGFDPFDPEAGAHQQNPFNFHGGDNPFAHFAGGGHGFPFGSTGGFTFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J772</accession>
    <name>A0A367J772_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multicatalytic endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPN11</name>
        <name evidence="2" type="ORF">CU097_009877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002039">
        <property type="protein sequence ID" value="RCH85679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J772"/>
    <dbReference type="STRING" id="86630.A0A367J772"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="100" mass="10768" checksum="DDF4AEDC34B4060E" modified="2018-11-07" version="1" fragment="single">MERLQRLFGSAAAGLGQGMQPGMDTPTVDNAEMVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQTKMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J856</accession>
    <name>A0A367J856_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001943">
        <property type="protein sequence ID" value="RCH86085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J856"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="615" mass="67959" checksum="86C77E25902EF5EF" modified="2018-11-07" version="1">MQSYDDRLTFLLPRPTWVNDMDVSFCYLCNTAFGPLRRRHHCRNCGNIFCQECSSRKVPLPQLGYGTKAVRVCNGCFDVAYLVTYIIDQDHGVSTQIHGVRGLLELAEKDNDKDLHNMVAYGGIDALVWVCRTSKNLTLHHLTTTVLAILAEKESVRPAIIIKWALPPLLSLIQLYASINHLKETSSDHSSAPSISSLSEDNAQNFALEILINCTHVLYQLSKAGILSQKEVIDEGVLESLLVLAAFDISLLKLASSGKQDGQTTDRINIIQSLAAKAISAISSQVSFQSSIIEVVQASGRLPCLLRSSNNEVRKYLAKAIAYLSLRNDKYKSSLLGGEGSRALISIIVRLPLDDLDKKTKSEDLLYYLATDTSDDADHPTAESSVDVAAISHACCALANFATNNESQLNLMLQPRLLRYICNVPATLPTHVEIHKHVARCLANLALYKENCSIMLGCNISESSSSTQAYNILPTLLALGQSPHATVDITRHVVRAIDNISSNVQLLSDDETELMRWKGKCQEIYPFITGILNTNAEQDNDTIKRAKSIIQKKIFEPTEKASITSSELTDTDISDDKENSSIKVSDCTTKNERRDNSSEHSTKSSKSKSKSKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8F4</accession>
    <name>A0A367J8F4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001915">
        <property type="protein sequence ID" value="RCH86217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8F4"/>
    <dbReference type="STRING" id="86630.A0A367J8F4"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH86217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17455" checksum="7157F16FB0320D71" modified="2018-11-07" version="1">MKAKSKKVKNTDILSAGSKIYAKKRKAKQETVEYVEFDPKKRQEYLTGFHKRKLERKNKAREKYAKLAKEEKLRSRREAREERQRLADKNVQEMAAMLRVGIDEPDQFDDEEEEEKEEEKKDPVVKEFKSETSLTTVTVIEDLGEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAP3</accession>
    <name>A0A367JAP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001758">
        <property type="protein sequence ID" value="RCH86965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAP3"/>
    <dbReference type="STRING" id="86630.A0A367JAP3"/>
    <dbReference type="OrthoDB" id="2286425at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="13"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="470" mass="53010" checksum="BEF086BF6884C836" modified="2018-11-07" version="1">MLFWTKLLTIAHATTISVHPFLILYYIYHLHLDVFIIYLLSSCAILLKMPAAMVWIHIIDRHPSLHGVLTGLLTAIGVIGILIILSIPPTWTPFILPSAIISCILDGSFFQPLEVVIDSAIIKILGDYKILYAKERNWGKFTLAIVTLVIGYFLEGDHDFDTLMVVLLIGSVALFLLSLSTNVQAVDPALLVGRQHQPLLTTEVIYKPYHIFGEHLSHISEEDASMLQRMTTTHSKYTSIIDQYASFDLVRLPYPPASSASIVLMSSLKISRSHEEDAQEKRVARFMQISFLCLGIVRGMTQSVIYLFLYDKLKMPTYIIGAVGSMETLSSLLADRLLIHVTEHVTHLWIVTCSAYTLSLLSTVVYIYLTMDTTLTQVSVIILQLCQGLSFHMIWLLAINHVNSSLLTEDKRMMLKGYLSTVYSYVGYALGVIATGYLISSNHDYTLIYKYSLLFILSSAFLAWEWTFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAW4</accession>
    <name>A0A367JAW4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_009129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001734">
        <property type="protein sequence ID" value="RCH87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAW4"/>
    <dbReference type="STRING" id="86630.A0A367JAW4"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001382">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="268" mass="30648" checksum="7DC8376BF5931C78" modified="2018-11-07" version="1">MNEGLLSVKNASGRQVSLLNTAEEESKRKYHCTEPGCNKSFTTSGHLARHNRIHTGEKNFPCLFPGCQSRFSRQDNMMQHYRTHMSPKSRRSQKRQANTQTTEETRPKPRLHAHQRIRSDPVQIEPPLTIDQHLSNYHQSLQTIPNAARFNQFPLPLSTVAKTSQVSSPTLSSASSSTNNQPVAETATTHHLFYQHRPLTYTPQNATNHLPFTLLHPKQPQRSQLRRTWLQENSNAFNKQDDEQNDRSKEKQNGNDLLQLAHIVSTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAX2</accession>
    <name>A0A367JAX2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002569</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01001728">
        <property type="protein sequence ID" value="RCH87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAX2"/>
    <dbReference type="STRING" id="86630.A0A367JAX2"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="12">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="614" mass="68111" checksum="DCDDB3ACC06BD116" modified="2018-11-07" version="1">MATVVSSISINNLTIVQSANLEYARLLSHSILFYEAQRSGKLPSNNRIAWRHDSALTDGSDVQLDLTGGYYDAGDYLKFTFPLSYTAFMLSWGGIDYYKGYELANQASYLREQVKWATDWMIKAHPSKCTLYVQIGDVRLDNNYFGPDTNIPLPRPSYQINETNFGTDVASMTAAAFATASSLFRMFASVTGDQKDAAYADLLLSHGVQLYSCSKTISFSRYQFAVPTVKDIYASTDYLDDLILSAISLYKATKNETYLNDALSYYQLPDWRTNHTEPLGWDNTYGAVYVLLAESLFNTSDPQTSIQSRKVAENYLDGIVSGTSVNQTKGGLLFWDFYSDDNSNANAMSASYLLLSYSRQVLRPLLAISPTDQVAISAKIKRYEDLAIRQLNYMFGMNPINQNYIVGERPNSPKYPHSALAAGFNSLADAIASPTDLSHSHTIYGALVGGPAKNDSFADQRLDWSQTEVALDYNACYQGILAYQAMYSPNGPYYETPTSSSNPTTAHVSNALPTWAIVIAIIFPILAACLLGLLAFMFIRRRRQQPLRQKSEPSTRYESDEGSTLQQDGSPKDFSQGSPASQKKTSVDLTDQGITLPRELLTESTTQRAPELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB32</accession>
    <name>A0A367JB32_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_009677</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001730">
        <property type="protein sequence ID" value="RCH87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB32"/>
    <dbReference type="STRING" id="86630.A0A367JB32"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="50"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="396" mass="43404" checksum="82EE706DCDB2347C" modified="2018-11-07" version="1">MSSSGRTLLIGIITGSIITVLASSLIAQLKSENKEEHDEPTTDIVEGVDGLIGNTPLMKIKSLSEATGCTILGKAEFLNPGGSSKDRVALNMIKIAEEQNILVPHTGSTIFEGTVGSTGISIAMIARAKGYRAWIVMPDDQAKEKYQLLEKLGATVEKVRPASIIDKRQFVNLARDRALEFKEGDAKGYFADQFENEANFNAHYNNTGPEIYRQTGGKIDALVLGAGTGGTLSGISCYLKQHIKKLKVFLADPQGSGLYNKVKYNVMYSPTEQEGSRRRHQVDTVVEGIGINRLTKNFDKGRHLINDAFRVTDDEAIKMSRYLVREDGLFVGSSSAVNCVAAVRAAKKLGPGHVIVTLLNDSGQRHLTKFWSDEYLKSQNIYAELKPEEGLFDFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC70</accession>
    <name>A0A367JC70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001647">
        <property type="protein sequence ID" value="RCH87485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC70"/>
    <dbReference type="STRING" id="86630.A0A367JC70"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="411"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="892" mass="100289" checksum="6AE0AB7FEBACCCAD" modified="2018-11-07" version="1">MSGMNFTEKVEKIIARAQALTREFGNSQIMPAHIACAMFDETDGAALFRSIIEKTGAEPTTVERGYKKMMVQLPSQDPAPTDVTIGSQTSKLLRNAEKRMKDQKDTYISVDHIILALSDDDTTFKPMKDAGITKKALEAAVSQVRGNRRVDSKNAEEVYEALSKYAIDLTQMAQNGKLDPVIGRDDEIRRVIRVLARRTKNNPVLIGEPGVGKTAIVEGLARRIIERDVPQSLQCKLFSLDMGALIAGAKYRGEFEERLKAVLKEVKESEEGIILFIDEIHTVLGAGKGEGSMDAANLLKPMLARGELRCIGATTLTEYREIEKDPAFERRFQKVDVGEPSVAATISILRGLKERYENYHGVKITDSALVSAAQLSDRYITTRFLPDKAIDLIDEAAANTRVQLDSRPEEIDVLERKRFQLEIEVKALSKEKNNKESNERLQAVREEMARIDEELKPLKLKYELTKGRLDEIRDLKQKLDELKSKAIQARNNYDLDTAADIEYYAIPDVEQRIAELQAEKQRKMSEDLANDQPSDAIISEVVRPEQIMEVVSRWTGIPVQNLAKSEREKLLTMETEIARHVVGQDAAIKAVCDAIRLSKAGLQDPRRPLASFMFLGPTGVGKTLLCKTLAEFLFNDERALIRIDMSELMEQHSVAKLIGAPPGYVGHEEGGLFESVRRKPYSVVLLDELEKAHRDVANVLLQVLDEGFIHDSKGRRIDFRNTIIVMTSNLGANLLADNVKGEEMNILKEKIMEVVRKHFSPEFTNRIDEVVIFNRLTQTNITNIVDVRLKEIEERLADRRITLQVSQAAKEWLGAHGYEPIFGARPLNRLIQQKVLNQLAKLIIDGGIRNNEVAKVDISADGSTIEIVRNHESEAGYVVEEPMDEDQDLDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCH0</accession>
    <name>A0A367JCH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001612">
        <property type="protein sequence ID" value="RCH87662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCH0"/>
    <dbReference type="STRING" id="86630.A0A367JCH0"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="211"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="434" mass="50109" checksum="F35F42A2F90C7DFF" modified="2018-11-07" version="1">MNPERLITSANWVRNELLVRLAHRIRDFQQLPFIVGTNPHIEYVYRLYWGAFETMRQFPPIQTESDNDAFCDLLRGLLEDGLLVLPKLARGLSESVAYYPPDQNDLDLFLNRMLRSRISRRVLAEQHLALTEACEHQWDSTLGYGDGYVGIIFVHCSAQEIVKRAKLLVYQHIQKYHYQQQNQPLHAPNIEVSIHPNSRDSENEILFAYIPEQLEHILYELLDNAVRFTMKRYPNANYPPIKVTVSANDSDVYFRISDQGGGMTKDRYERLWSYQARARTGDFDEIKEVEKLPTTVDGRANQVLQMGHRHLGIGLTMSRIYAEYWGGELQIITMDGYGTDVYVRIPRLGTSIENLGIDYQTHPVFQDDQHQKLLLKKKDSKHAVKGSHKKQGIRLQSKPDENLAATKQKELLDTSLTSKSFSGSSWSESHMIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDR5</accession>
    <name>A0A367JDR5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001538">
        <property type="protein sequence ID" value="RCH88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDR5"/>
    <dbReference type="STRING" id="86630.A0A367JDR5"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="5">
        <location>
            <begin position="121"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="255" mass="29407" checksum="7B478398D71CC396" modified="2018-11-07" version="1">MDRKSRSSRLHEDMNEEVNLWKQICYSLAKLEGLQKDEEVVINTINKFHYSLEKGISSAIHQKLKESYKRGIELSNHESKLVRDIIEKLTVLIALKDTSEQDQKRKKRKTEGADSRFNGSAHAIFTKGTTVAAKQPDKNDEWILAVVIQYYPDRNKYQVEDVDQDEYGGKQHYMLSPKYVIPVPTPKEAEMAPEIPAHQEVLALYPSTTCFYRAVVISPPSKNKDIKNYKVQFEDDNDEVKQVAPEHVLEMPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE27</accession>
    <name>A0A367JE27_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001524">
        <property type="protein sequence ID" value="RCH88135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE27"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="125" mass="13915" checksum="F2FAB88190D9C112" modified="2018-11-07" version="1">MSNKQFDITVFGATGLTGKQIVRHLYQLSQEHPSLYPSQFKWAIAGRSEDKLQTVLDEIVSQYPEATLSKPTILTAAVTQRDKLDAITSQTKVLINAVGPFRFMGEYVVRSCVEQGCDYVDVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFA6</accession>
    <name>A0A367JFA6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_009187</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001470">
        <property type="protein sequence ID" value="RCH88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFA6"/>
    <dbReference type="STRING" id="86630.A0A367JFA6"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11177" checksum="47F2CDD6919F47E5" modified="2018-11-07" version="1">MFSRVIARSSRLSCRPAFIRRGGHGTPSYNEPGGYLFNEKVRVKEDWENMYYLGMGGGFLAIAVALYYKPDTSVVTWAKKEAEKSLKEKGISLEYTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFB6</accession>
    <name>A0A367JFB6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_005771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001427">
        <property type="protein sequence ID" value="RCH88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFB6"/>
    <dbReference type="STRING" id="86630.A0A367JFB6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="172"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="438"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="66803" checksum="F221C59A1BD48E16" modified="2018-11-07" version="1">MHSSKEEQIRITIYETTLTVQQNTLSVFHVIIQTPEQKVSLVRYPFDFVEFHQKIRFHFPKVKISFPTLHNPSQQRVNKRRSIQHLLFPFSRKSNAEKLQKYLERCFRHPVVSVSSILRDFTRVQRDEDVVLMTQLTDTTLTLTANQSTDRLVIPPKLNKQMPPLPATMDDFNLIKVLGKGCMGKVLLVRSKRDDTLYALKAIQKKWVLKQKEFAHTRAERDILVGLRNQSFIVHLHHVFQTPSTLFLLLDYHPGGDIATQLSLMSKFTPERTRFYAAEIVQGLNVLHSHGIIYRDLKPENVLIQRDGHIVLTDFGLSKIFTAADVDQEDGMPYTQTFCGTAEYLAPEVLLGEPYTFVVDFWSLGTLLFEMLAGITPFWAETHMDMYRRVIDDPLEFPPSFDQDTCSLLSGLLKKEACMRLGWGHDGIEYIKAHPYFERIDWDLVAKRQLEPPFVPVIKNEQDCSHFDDVFTSMPVRISQDSREQDGVQPILDPFVSFDYDSLLIEFQQNNKPRLRKRQSASMTAEHIDDDRANKKRQLRRRDGKLNPSMTSTLNNSVYSALTVENHQQVLLIQPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFN2</accession>
    <name>A0A367JFN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_005933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001419">
        <property type="protein sequence ID" value="RCH88717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFN2"/>
    <dbReference type="STRING" id="86630.A0A367JFN2"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="113"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="419"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="478" mass="53156" checksum="24199162D6C942F1" modified="2018-11-07" version="1">MGFCHRCGEITRGKCVKCGGRPVESTISCLVAEAGGMSIIDKWQSQYADTILAPEEIIKKSHLNAKRIPTAQSAFYTNQKVCSCCSKTLDYTTILEDGVPYCRQCHLKLYNKGQCPACNEPISEHDSWIEHANKKWHNACFVCFNCKKPLEVNPLVDLQERPCCEPCFMAQAGKGTSRKSWYSDDSISSQSSLSSSGSTRSSILLSRYNHSRPRLDRDLFQPSMSTPPLSRIPSPEDSKDLLSRKSPSRPKITIPKPAAISTSLNSPPSSVSSPIIKPISQRPCNYCHEPLGDTGKKLKLSLPSGQYAWFHKSCFLCSRCHQPFSSNECATDGKSFYHADCGTKRCFACKKPVTDDCYKFQDKAYHFDCFTCQGGCGQQISLGQPFFEVDQVPYCQSCHDAQSQPKVRQRVLPKLGGQKTCPKCKKPISVMDDTPGPLASRWHKKCLRCTKCSKQLDSAAKVYTGSQGESLVYCRTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFZ8</accession>
    <name>A0A367JFZ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NPY1_1</name>
        <name evidence="12" type="ORF">CU097_009766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001396">
        <property type="protein sequence ID" value="RCH88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFZ8"/>
    <dbReference type="STRING" id="86630.A0A367JFZ8"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="296"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="442" mass="49396" checksum="6947496A64BC1E1B" modified="2018-11-07" version="1">MSNNVFEAAASGDLDYIRSNLAHINDKNEREWTPLHFAARFGQQEVAKFLKENGADIHQTNSEGKTAAQLATFWGNTEIANLLQETSTVVRPFPDNQINVFAGNHLNRYGWARNSAEFLSELAKSPRSKYVVLKELKALYDESGQLHLVSYNDVASIVDKVYTENGFNKTNDEIILIFLGIDETNGKGRDGEAYWALDLTPKGKYEKELDALAKVYESSSFEFCPTLPRAFTLKGSTSAIIAQAAAMVDWNSRNLFCSACGSKTVMAEGGHKRTCTSTKEAPKCISHVGVQNFAYPRTDAVVIACIIHPNEDKILLGRQKRWPKNMYSCISGFIEAAESLEEAVRREAFEETGIIVNRVAYHSSQPWPFPNSLMLGFHAEALTTQISFSDDELESAKWFTRSEVMAAMKGEANAPLNLPFKGSLAYVLVDAWLHDKRWHNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGB9</accession>
    <name>A0A367JGB9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001362">
        <property type="protein sequence ID" value="RCH89022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGB9"/>
    <dbReference type="STRING" id="86630.A0A367JGB9"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="438"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH89022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66408" checksum="D7B41986E00F5196" modified="2018-11-07" version="1">MTDNWDRTFFDKELKSILDSKLPVSASKITSLQQLATSHPKHHNYIIQCITKFIESAPPDYRLAGLYVIDAISRAVHKQLRRREENNEKGSFEAEGYLKRFAIVLKDDSLIGCFESCSTKDKDKVKKTLDFWEQGSIYPKEVVQYVKDSFLKQMSPPVDTAALLATLSNIGNLNIPGLTSNNNNSSSISNSSTSSNSSNGSYTTPITNTSTTNTTTTTTTTNATTTAAPVTQQVNKDLSLPPALAKLLGSLVTTPTPALTSAQVQAPVTNTPAQVRLDPRLAASESKTKPSIWPPPQGPSVPLANIGRTEKKSRWGNDTDNIANKTTTTTTTTSPITVTPHTTHTTSTITANSSAQEPWLHRQMTQTANNNSNNNINNAPIYQQMNQQLYQQQYQQYYQQQYQYYQQQQQPPQQIQYKGAQPMSDTSLPPGCIRVLTRTLFVGPIPDHYEREDVARLFAKYGEIASVIVSKKLKGRHNAFLKFTTRAATEAAKYDGAGLMVEGMPVKVNWGFGFGPKKHFNYDRGDSIIPLAELSAEEKDNLVIARVGGFQGQPVRDRMVIEEPEAEYKPEWKDDERGVKRYNNQFEDNRKRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGI5</accession>
    <name>A0A367JGI5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001368">
        <property type="protein sequence ID" value="RCH88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGI5"/>
    <dbReference type="STRING" id="86630.A0A367JGI5"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="488" mass="55330" checksum="BF6C31EFC3B524ED" modified="2018-11-07" version="1">MMDESEIDRIYSQQLHDELQSQTKAAVTQLIELYPEIFGLDRLIAPKNQYMQQQNLNEAIAQTVRDTCLAYIENGVNFDHALDWVLVWRQQLSFKSLGEKYGQEQVIASIGHPRARKAVQHIYQESLDKYMQWFPWSWFSRMQFIGAGGFSAVYSVTMTPAYDFQPVKMALKIVDDKILNEISVQSRAFLPLLFQGLTVCETTGDLMMVMKFSNDGNLEDHMAQLPLGDLDLKTITGTILRLAANLADLHKVGICHRNVHPRNIVCTDSDYFLVDYRFATPARESSSVTAITKAVYGRLPYVAPEVRQGVYTEKSDIYSLGVIIWQLVSKVIFPSSDVLLDGNHKNGEPEDHVYRVEPVPGLPEWYQKLYVACMEPRPENRPNANDICTALQPIHDALEFSVPLDRRVTGYIVARRAEVADHLRTYAKVKGTISDSTTRLYTLSSLPSTQSFILLPFESQPFHTVWNSNSCVLDTFSLSAYIDTSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH54</accession>
    <name>A0A367JH54_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dual specificity protein kinase kns1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KNS1_1</name>
        <name evidence="9" type="ORF">CU097_009149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001326">
        <property type="protein sequence ID" value="RCH89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH54"/>
    <dbReference type="STRING" id="86630.A0A367JH54"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="130"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="446" mass="51600" checksum="59125C2A6E973C75" modified="2018-11-07" version="1">MMTRKRTADWEKDFYKNGYPKEVIVIEDSPTPSPPSPAHYANAPYTSTFSSHVTRKRQAEQLPVITKRTKLETMHTDPIFAFHVLPTPTIAYTFQMPPPIILQPPPMPPVYDDKDGHYLVRLNESLTPQYKIMRLLGQGTFGKVVECYDRVRRTFCAIKIIRAIPKYRDASKIEIRVLNTLKKHDPLNLNKCIHLVEWFDYQNHICMVFELLGQSVFDFLKANHFKPFPHHHIQQLAKQLLTSVAFLHDLKLIHTDLKPENILLVNRGSNTLDENTDIRLIDFGSATFEQEYHSAIVSTRHYRAPEIIMGLGWSYPCDMWSMGCILIEFFIGDALFQTHDNLEHLAMMESVLGPIPTHMVTRASKEAQKLFEKDSKKLNYPLPKTSRQSKRLVSGLKPLDQIVPPVTTFNKHLNDLLKRLLVYEPSARISAREALRHPFFQNQCMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH87</accession>
    <name>A0A367JH87_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phe-4-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_003635</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001310">
        <property type="protein sequence ID" value="RCH89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH87"/>
    <dbReference type="STRING" id="86630.A0A367JH87"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03347">
        <property type="entry name" value="eu_PheOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041912">
        <property type="entry name" value="Euk_PheOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="13">
        <location>
            <begin position="86"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="433" mass="49613" checksum="6748CB8CBE61D8E1" modified="2018-11-07" version="1">MFKTSPNNVPKETLKTTLCFSITDQVGALENCLAAIKAMDISLTRIESRPSRTKEWDYDFFVDFDAKSAEQVNQVVCKLRDHTKEVRVIGADSTKADSVPWFPRKLTDLDTFAEKVLEMGEELSSDHPGAHDPVYRARRAEITRIAKTYRTGQPVPEIDYTQEEIETWGKVFRRLTALYPTHACREHQYVLPLLIQNCGYNDKQIPQLEHISRFLKDCTGFTVRPVMGLLSSRDFLNAFAFRVFYSTQYIRHASMPFYTPEPDVCHELLGHVPLFADPDFADFSQEIGLASLGASDEDIQKLATIFWFTVEFGLCRQDGELKAYGAGLLSSFGELEYCLSEKPELRPFDPEKTAVQKYPITEYQPVYFVAESFKDAQEKVREFAAKMNRPFSVRYNALTQTIEVLDNKEKVVRFARSIRDDMKTLTTVLESLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JII2</accession>
    <name>A0A367JII2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001274">
        <property type="protein sequence ID" value="RCH89521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JII2"/>
    <dbReference type="STRING" id="86630.A0A367JII2"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="9">
        <location>
            <begin position="124"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="752" mass="83123" checksum="8BAAFEA6B2016D2B" modified="2018-11-07" version="1">MSKGKRTGFIEKQIEDLTKELQSISNKQDSKTIASILVKRGLLYESMNQLDKCQQDIQTAFKMDPTNQELKSLLMRVTASKEHPETNKQDNNDPQVARFQEILHKLDTVDANSVKSLVSSNDFISILTSCGSLNTSPRVKSLAFMILSKLFNPPSEATSKYPLTFIIEKCAACFSYSVGQGKNESKLLAYRTLQAIFQTSMTVGSAILCQEGTVEEMMDTVEFEIVPVQIAIAEVLNIASSDKSCRKQILKYATDWLAKMASQNKTDPHLKAAAGTILTKLKAQSDMPTDEPTEGLSSDGSVHSDNLSDSMRKMQLTSDDLVDSLKQVIKSKSSDANIVLNALEGLAYSSLKPEIKVSLGEDDEFLKCLSTLAINTVREESSTSKNPLLFGIGTIFANVTMYRRILNEQEKQMKKLRDLANAKQRQAEGKPAEVNDDDDPREQDSAVEGRINKAIKNGISLALIVLSKSDSANIRAVAAQTYLNIVTPQKTRGQLLQQGVIKGLLPLSRDEGTTGITASQALAKLAITADPRLAFHGDTILDLVRPFLNLCKDSSQLRQFEGLMALTNLASVEDRARLLIENADGMSTFENLQLSNNDMVQRAATEMVCNMTFCDPVFERYSDPKKSQNRIRLLMILSDHEDPATRRAASGALAILSNSPGTCEMILKVDKCYERMARWLEAEETVEVKHRGIEVIRLLLQHKGKQVIEGLCKEGIDKKLVDVVKNCNVQVVRSLAVEVLKQLSENGVKIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJF0</accession>
    <name>A0A367JJF0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001189">
        <property type="protein sequence ID" value="RCH90026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJF0"/>
    <dbReference type="STRING" id="86630.A0A367JJF0"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="26890" checksum="725E604D4EF0548E" modified="2018-11-07" version="1">MDLNSAITLEGSSHLVVKFFGNTQMWFDTVKKILSIKKNMYLISLNDSILYQRGIYPSDDFDVTTKYGMNTVVTNNPELRQYIDKIIKQIEIWLKSNSISKLVIVIRSVETDEVLERWHFDIELNNGENGIPMPENIPPEQAVEIQKETIRQIRGILRQITSSVSYLPEFKEECKCTFNVLVYGDKDIEAPVAWSDSDASLIKGGGEHVKYKPFSTLVHKVEPFVAYKPDDDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJL5</accession>
    <name>A0A367JJL5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001177">
        <property type="protein sequence ID" value="RCH90096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJL5"/>
    <dbReference type="OrthoDB" id="2253209at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13457" checksum="EB2967D4FEBD83FC" modified="2018-11-07" version="1">MNRINKKRQELVDIEQRLMETKDEKSIKPVEPAMIKDDIYFQPILSTAPPVMTPQKKTIKKSILHKIYSFRNPSRSPPLKPCRPSSMRLPSFLPMQEDISVHPPPYQDSISYQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJS4</accession>
    <name>A0A367JJS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001163">
        <property type="protein sequence ID" value="RCH90187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJS4"/>
    <dbReference type="STRING" id="86630.A0A367JJS4"/>
    <dbReference type="OrthoDB" id="6259853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="47440" checksum="34212791DCE613F7" modified="2018-11-07" version="1">MGMLKSELSFDQLMAQATLVAKQQDAALLERARQKRREDEERRRREERAMREKREAQELLAKKRELQEKKQRQLVEQKKQQKRQEKLVKARPARPDPRTILPEKKKPVQMSFEDLMKKAKEQSLVKKENSTARKPPITTNTHTTAAKATTKSSATVHHGPSLYHRTKKPESKNDTNNNGQSTLSVRERAKLLVSEPPKKVIGQKRDKRSIAEVQRDIRHAKGIYSDDEEDRRKNDPRLMINKNKPTQRYQSSDAAIGRKRPLSPPRLAKKLDVPRRPVMSAPIPRMPFSGRPLDRNAAKLPVARRYINDDDDEDDDLDSFIVDDDEEEDPYYKHKNSYSDEISKIFRYDRSRYANEPVFSDDDMEANASEVLREEKRSERIARREDLIEEQKELERLKRRKKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JND7</accession>
    <name>A0A367JND7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CWC25</name>
        <name evidence="10" type="ORF">CU097_012995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000967">
        <property type="protein sequence ID" value="RCH91462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JND7"/>
    <dbReference type="STRING" id="86630.A0A367JND7"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="13185" checksum="06B3A17E7A4D5069" modified="2018-11-07" version="1">MGSSDLNLKKSWHPSTFKNQERVWKEEQKRKEEERKLEQLKKELAEERQLQELQQMQEESGAKQKSNKLDWMYAGPNASMNGSNDNSMEDFLLGKKSVDELLRAKQRQEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPB0</accession>
    <name>A0A367JPB0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000930">
        <property type="protein sequence ID" value="RCH91715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPB0"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016983808" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="145"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="575" mass="61636" checksum="34B90CD81A46B366" modified="2018-11-07" version="1">MLITSSLLLFSAVLKANAATITTSSYLAQVSPVFPSKIPTPSGVVTSYQDGPYDTVSSLDTTPLEGFPTTWEIPPTDSDEVQTIYNSINWNKVPSAPVRKIKSDGSFSPSSDGSSDPYCYWSDTNCVKPKASYLPPDLYECPKKGDWGLTYDDGPFNKVSTSESYASVENSYAEPALYNFLGKKNIHASLFYIGSNVVTYPAAARLALNNGHSLCVHTWSHNPMTTLTNAEIVAELYWGIKAIKTATGVTPKCWRPPQGDVDDRVRSIAWQMGMRTVIWNEDTNDWDMPDPMNGGNLPSKTVDGYFQSWINAQKAGTLKTGILVLEHELNHMTVNMSMYWLPKLQSTFNVVSALECNGISQPYWETNFVYPVSDGTTTTTTTTTKTTTTTTKSATTTTKSATPTPNPACTSGSFGLENGDGYNGYCCKTQADCIDDCINGKCNGPANPNQSTTTTTTKSATPTSNPACTSGSFGLENGDGYNGYCCKTQADCIDDCINGKCNGPSNTKTTTTTKTSTKTTTKTSSKTTTKTTSTGASSSCVAGYKGKRKGNGPTGACCSSSDDCIETCRKGVCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPE5</accession>
    <name>A0A367JPE5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MID1</name>
        <name evidence="7" type="synonym">ALG13</name>
        <name evidence="10" type="ORF">CU097_007742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="PJQL01000927">
        <property type="protein sequence ID" value="RCH91739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPE5"/>
    <dbReference type="STRING" id="86630.A0A367JPE5"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="613" mass="68443" checksum="084F29D4102CB010" modified="2018-11-07" version="1">MSVFITVGSTGFDELIKVTTSRLFLDCLSQLNYKRIVYQYGSSEPVFKRNLMDYKGNMDIEGYQYKPSITNDIQAADIVIGHAGSGTILQTLRLNKKLIVVVNKSLMDNHQYELAQAMHIKNYAICSDTSDLVNTIQTIHRFKPAIFPEANERVFAEIVNRHMVFASSTSAAYQHYYFSIPTQIQLLAQKPNIYLSITSCNQPELIAFLSTSNTTEPQNGIRLDNTHGLITWNSNHSVSEIWIAISANQTKDNSGQWSYEIAASTQQIMHPVYVDSDPTAPYITLDDTDRNSALFLSNILSEPFPNSTILITSGQPTDLSWSLCAAKLHSVPQLSINRTITTRGPTNATRYQFLISNLTDDTSYQAYLLQETNGVTGISTPIPIKTKASAVCQLIYDLPFCNQVAYSVPSNSAVSRWDLAAQYDTQAQALFDPFDVSLSQFNCESTQYSLVRNCTDCYRDYKTWLCSVTIPRCTDLTSSAGLIQGSDNIKAAPAVRDVPVNGSRNPWIDSTLQPSAWTELLPCIDLCYHVVQSCPPYLQFFCPVGDLASVQYGYWQTGNATVNGTTYQFNLNNPTCNRMGLDVKLLTLSSQGHKLRIFSCSFCIVFFVIFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPQ0</accession>
    <name>A0A367JPQ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_006683</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Plastid</location>
            <location evidence="16">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000902">
        <property type="protein sequence ID" value="RCH91922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPQ0"/>
    <dbReference type="STRING" id="86630.A0A367JPQ0"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF135">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 120, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AIG1-type G" evidence="17">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH91922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="257" mass="29336" checksum="BFDA4B56DF7D4D03" modified="2018-11-07" version="1">MISGEEKNTFVVSALGAVGTGKSSLLNAITGEYTFETGNGVELTTQHVNGITKEWKFAPSLQYCHLIDTPGLIDSSVHDRQSIQEMIKYFKSLQYGVSAFFLVFNINDIRLDAYTQNMLVLFHQLLGKDFWNFVIIVFTHVDEEFRDDLEDNMDAVTASDDGFVAEIRRIYKLSKSFEPSVVFTSTQNVRNSSYTQRHIRELYYAVGMCEARNNGKRFTCNWFKQIMSIPSEEQKSNFIAESIKDAWSSMSNVCQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPW6</accession>
    <name>A0A367JPW6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000892">
        <property type="protein sequence ID" value="RCH91990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPW6"/>
    <dbReference type="STRING" id="86630.A0A367JPW6"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="241" mass="27076" checksum="99978AE428761F19" modified="2018-11-07" version="1" fragment="single">MSCKNSSFVFNQCTAIEECGHRFCLECITEKLRQTPECPVCKVPTQSNDLHRDYLQDNLVDYLDQLKKLSLNHTLTPLELSYQTRSETEEESSLTNLIGKRKKSPDSSPRKRQATDQNIDALLESVIVENPEQEHDALVDKGDDAKNQTKDEANNSDIQWKCPDCQFDNPIYVQTCSVCRQPKNMPVIQGTGARSVPKTANANKGHEAQSYMPTVAADNEPESATIAPDKAQSTENNKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRS2</accession>
    <name>A0A367JRS2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RAD30_2</name>
        <name evidence="13" type="ORF">CU097_010804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000797">
        <property type="protein sequence ID" value="RCH92662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRS2"/>
    <dbReference type="STRING" id="86630.A0A367JRS2"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH92662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="589" mass="67219" checksum="017BD87FC3903179" modified="2018-11-07" version="1">MACPCNKDSCKCSAASCNCGQNCTCNDCGAKHSDACACKDCFYCQVEQVRLGISSDVPTAVQQWQNLIAVNYPARKAGIDRHCTVAKAKELCPEIKLIHVPTYAANEIEPQYRENPNRATHKVSLDPYRTASLNIFKIFHKYCDKIQKIGLDEAFMDVTSTVNQRLVEYIDCHPELLDRLDDDACDLDLDWDQVGIAIESKEEEERRQLEVDGSHWSKATWRDLQLYFGAELAAKIRHEIYTTLQYTCSAGIAHYKSVAKLCSSKNKPNKQVYLHILVSLLFIHLVDIKTVLRDSAALYFMEQVPFTKIRNLGGKLGSEVESSLSIDKASDLWKYTIEELQRKFGDSTGRYLYNISRGVDNEEIIPMKAPKSIMAAKQFNPAVENIQEMDRWFSILAIELRNRVLKNYEEFNTWPKTFTLQYASIPYLSFRSKAMGSISREEMKDHENIAKKLEKVFKSVGSPMPCSGLQFSASNFIQGASQSRSIHQFFNKIPKSSNESSVSSPTCSKPTYDKSRTVAPLWDQDIDESLEYLCDKCHKKVLLVNIDEHTDYHFALDIQRQVNQELNQSKKRANDDTQESNKKNKFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU23</accession>
    <name>A0A367JU23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gem-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GEMIN5_2</name>
        <name evidence="3" type="ORF">CU097_007856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000700">
        <property type="protein sequence ID" value="RCH93416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU23"/>
    <dbReference type="STRING" id="86630.A0A367JU23"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="2">
        <location>
            <begin position="802"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116279" checksum="51B35F3050517412" modified="2018-11-07" version="1">MDLQDKYPKCQAYPPVPNWYTSNIAAIIEPHFFVYATRNIIVILGLKDFRYFNSITAAKEKINAIDAHDVFCYVGGADKTVRVWNIVANSLTTSHAVHKAEITALKVIRKGTVIISGDKAGRVVVAEAFRKDQTISAKVNSEVTCISTVHRDHTDYAAIGYGNGIVLVEEITENLELKTVYQFSSENDPIMAIDWQKKFSDGQWPWLAYSTKRLKRIVIYDIPSQTEVAPIHLPKPPAKATGQQVSSAWIEVSWSPCVENRLYVTSYVGTILVFDIAPRAAKIRNQERMENHSRNVFSINWYNGGTNCITTSLDSQVIKWNVNNQKCLQVMKTQAAFPYALDISPTAPYRLSIAMGDNAIKLWDFQKNESVMGSKGENHNYYTSSIVWKGLQGKTLRILCHPSKEGLVAYVNEYGRLGLYDTLNQRYTYFKQLYKSMECPMIAWGFDLSTCLYDMDMTDTLIACSSNDVNIYVYNINQPNQPVIALNDILEQRNPLWYDTLKSKDGVHRTCMAIDKKCIAFGHVDGVVEVYCRSTLQLVYVSNFHRQKITAMDWKDDYLATASEQGIVAIHDLTSQMTESTDTVLPTSEIYKSMQCNQKTITVLKWTREPNKYVLAAGLQDGHVVVWEMDKIIAVFDQHRASILSICWNHCDQHVLFSSSEDRFIYQWSYMDYKVSAPIKFGSSLYDREMTRINQHGSKNNKRKKDGQMDSRLCDLKKQKVIEVNKDMMVSTLQSEKSASRLNKERKCMYLANVMFDGRIEAVMKELLAELNEQERSDPLVNQYAGIFTANDSHEPDIYEFLFGDKEDAFQLARIEEKSIQTKASTQSINDMSIGFDKQLAMNLMLSQADTLFDETKSSILDWIVLAMSPQAGKDVWIDLMKKQAKKMERENQYHLAASCYIACSHIYDAIEIYQRYGLYREAITLAKLRLPKDEQLLSELYLKLASQFQTGEEDQLAAICYLLSKVPGSINNTLDLLSRTNQESGLFYSLCLSVVTESSDISEQRKSKWIKVLRERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUK9</accession>
    <name>A0A367JUK9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRPT1_1</name>
        <name evidence="7" type="ORF">CU097_013436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000669">
        <property type="protein sequence ID" value="RCH93672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUK9"/>
    <dbReference type="STRING" id="86630.A0A367JUK9"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23591" checksum="9D8ECD0AAB7F1ADB" modified="2018-11-07" version="1">MSSQPEEKVTSLSKKLSYVLRHGALKEDLKIAPDGFVKLDDLLKLRRFKGVSYPDIQYVVDHNDKKRFELKEENDVYYIRATQGHSIPVIDTDELLEKLDKVTTPVIHGTTMKAWESIKNDGLSKMNRLHIHFAIGLPNDPNVKSGVRKSSEVYIFIDADKAMKDGIKFYKSRNDVILSDGINGTIPPKYFKKAIDKHGDVLYEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV00</accession>
    <name>A0A367JV00_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_010794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000657">
        <property type="protein sequence ID" value="RCH93770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV00"/>
    <dbReference type="STRING" id="86630.A0A367JV00"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016810793" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="85"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="505" mass="57235" checksum="1CE27A3C69119F3A" modified="2018-11-07" version="1">MVFLFPVALGLLVVSNAVQATIQQVDPKTIETRGSGALFVEFFQPNCASCEELTTQVEQIASKYRKENTAFVRINCDDYKGYCRDKHVEAFPAFLASLDRGPWKRLDPNQQTLEEFVEQNKPYRNTKGESKSITTREEIEAIVKSKEPWFIKFYAPWCGHCQTLAGEWVMAASRLKDKVNVGEVNCESNKDLCNEHKVTGLPTLKYFIHGTSIQFHGERKADALVEFALEHTGSAVRGVRRDQLFDDLLKKSDVNLVYVTEKQTKEHLEQLEQIAPSYLQSIPFYTTSDPSSAQRFGLSNLPAIVILKDNQQFVYDGHQDLSAWIKNHSKPLVTTIYPHNSREILKEYPGLVVLGLFNPTDTSSHEAFRHLSAQCQRDDILFAQLDAWEYAPFVSRSYGINLVHLPAVVILDSSHQQYFKTNKDEERFDVQAHPQEILDSLDHLDTLTPISTVPPKLISYAANAVNYIMDYWVLFSSGAVALLALLVILLAVTGNEQETPKKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVY4</accession>
    <name>A0A367JVY4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000623">
        <property type="protein sequence ID" value="RCH94065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVY4"/>
    <dbReference type="OrthoDB" id="2405722at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="32651" checksum="B116FFF4A10B62F1" modified="2018-11-07" version="1">MDTHLNKSTQQQQQQPAAAKWIQNNDDSDTDQVGLVPHNRKKRMVIKRKRRRIEDGLSDEEEDPYTLINIEDILSPIEVPTDIVRRPALRRILRSTQIDALAKTSMEFIEGEKNFNKVLCRLSAILHQDDPRYLDLTFDRTPAQIKKYKEDTEAAKAAAATLTAAKNESDAVDDLDPKELAEKVEKTCVPLEAKKEDDEPKELEEEDYTEEGVDVEARSIVKRVKELLLENINYSNEYMSCLQEARNKLCKASMQKEALWKELLSAAKEEDRRNKAFEGREYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWJ7</accession>
    <name>A0A367JWJ7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator hfi1/ADA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000600">
        <property type="protein sequence ID" value="RCH94239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWJ7"/>
    <dbReference type="STRING" id="86630.A0A367JWJ7"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39951" checksum="5D8A9AD7C4595D38" modified="2018-11-07" version="1">MSAATATTAASVATTPATKIEPTEGDDALKDTVKKVSPKSHFTHSTANGRQDVLAIKQQLADALGENGPLYWDALRDFVMGRLNRQEFDFYANLYLSRQHAHLHNAFILSTVHNAQTDTPPPSKHGLVGWAKRKRGKDGLLAEGGQDMDPKKKRLKMDVMALSKADRERLKALVKSGDRNKLKPYVDRLLGTRVSRPPQLPIPLNQLPPTYSQEYSKGLMAPLCIDMKGLPTADALHSRMTSIAIENGLLGGIGEDVVNIMLFAAESYIKSSITSAITKRRINRSIGIKKSVDTEEETIDNTSISLHDLAFSYNITPYVLVEKPLYAEKLTALLSDSEDEVIVDNLNEASDEEYCCPPYISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWQ5</accession>
    <name>A0A367JWQ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carnitine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_000668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000585">
        <property type="protein sequence ID" value="RCH94366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWQ5"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="146"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28149" checksum="4ACA291E7F0C4FF1" modified="2018-11-07" version="1" fragment="single">ILEYFEKHGRNGRGSMFKGVLSPVVGLAGLNAILFVSYGSIIRYFEQQYPNDKDPSLMQVYIAGTGAGFACFLLSTPTDLVKIKTQISKLPKTSWQITKEVYYTSGIRGFYQGGLVTAIRDSPSYGIYFWVYEGLKRVLQVNPIESEAWKLLLAGGMAGTVSWASIYPIDVVKSRLQMQKQVKGDNEARRLLMTDQPYASIRDCVMRSYRTEGLGVFFRGLWPTLLRAFPVNAVTFYTYEIMMSFLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXA0</accession>
    <name>A0A367JXA0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000564">
        <property type="protein sequence ID" value="RCH94563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXA0"/>
    <dbReference type="STRING" id="86630.A0A367JXA0"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="120"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="960" mass="107253" checksum="7EF8C0A4CDA88C6C" modified="2018-11-07" version="1">MPRQNPFLRRASSPGDINNNESNGQTTPVPPVPSFHPGKLAQASLSESALKVPLKPVAFKNTQPRATSMRPSRFIKASTPTSSTSSPLVASDHSNGKETQIVNNPEMISFIGLFEAFTQKVYIEGYLMRYNDTECSNSSTVSFSSDDSQQKKTKTKMFVELSGSTLILWDAEAPGSSVMPTYTQIMDTATVYGGSIEDGNKKTKYVFTLCSNAKSKTMFETSDYATMVRWVSAIRLSCFEKQRLHQLFTHKLLISKEPEERKSMNSAYLQVRMPGTTLWKKYWVVLPGGKKTKSNKAQHVSLYGSKRSKTPLLTLSDISHVYAIYPESPQLIEKGSMIRVDCKVNDKEETCWFMADKCEVTIQWLFSMFDKFKLYGRPLGLLNDCLNPSSLNFGEPMQTSNSVQRLFLEVDQVIKTMDIASIPVKHIEETFMEIIKNSQSLEPPVTRPTGLRANSLPLITVISADDDEQITQQRSSSDNIAALHGDKQNGFETDSTNLSFKFARHVADSSDESDQDDEDIEDEEEEYDSDNEPIGRKTNSRTNSTVATPSPASFADSLIPDFDFGNGFDVPKDVTAAAVAAAVVNASSSLSSSSVITSNSLDEEYTVPRKHIRKLSVPVNARHGSSLNEAPSSNNQESSLFGDFDLTGDFGKFLDLPMDQHQRKYSLPAKLSFDRSSESRSTTSSTHSSHHNNNYQNHSRQWELDWNNEMQGAESPQNRPKHPYDDDSYDSDFDGPLIPSLGDHFAPQNSLLDTYLGEHLSAKEQVEYAKATGQPLIQMPVKKEGLPQGGLVGVISQREKDKKEGNGFRVAERVNQHYQDRIEREKERRILEQRQQQIMKHQMMLYANGYGMPMMPFVNPVMNPMNFMGMVPVFPAPTNNNNNTSPCMTPPPYPPLNSNASSPHMSHMRPMYGSPSPMNYHHQSPSLSAPLMNRNSPRQSDELDANSGPLFRKHSVSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXT1</accession>
    <name>A0A367JXT1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000548">
        <property type="protein sequence ID" value="RCH94695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXT1"/>
    <dbReference type="STRING" id="86630.A0A367JXT1"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="563" mass="65198" checksum="EB3482BA1F510CA3" modified="2018-11-07" version="1">MQVSLPEINIPNLDDWEEMKLNEKDNTKESEGLTRAHSLQRNLNQITEEGNLRKEVINIATSNPSHLFWVPASQHPEIAPTEFEKYVDALGFMIRRKSVKRRQSVLSVYFTADEPKFDEEDNTKEKQDEDELKRRSLMRRSVSLHLPNANGYYIKYVFNSILTSLSLDDHSVPDFLKFDRNSSPLDQSRAIVPKTDRRPLHRRGARAKRNPSTTAGQQQQQQQRPMLRTRNSESDFYAPNTSPEGITLVDDECLPIEDDQVVKEEKEIKEQVKELEIASDKKEDNKPQLTMTRSMSTSTASSRKSAWSWTFWSDEKSSKKNKVDPVDHDQPPKPPTDNTIPSRRFTLSSLFSRKSKHTPTDMEEKDTLQAPKDFQLNRMYMTRLPLHVERAIYKLSHVKLANPRRPLHEQVLISNLMFWYLSVISTNDSQQPPVKTHKLIKKKKRPPQQKKTKVDLKSTKGNTAFMPNPSSTRHQSTGFVVPENYLNPRQHTTKRKGTRQQLDSSSDEDEDDEDEDEDDIEEEDDDRIFNSNNNSRSSSSSSSSSRLKKDDDLPLAMYKIKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ17</accession>
    <name>A0A367JZ17_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000497">
        <property type="protein sequence ID" value="RCH95147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ17"/>
    <dbReference type="STRING" id="86630.A0A367JZ17"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="339"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63118" checksum="F89C7AD96F1977F1" modified="2018-11-07" version="1">MGNCFPVAHRAQPISDRNIISQEDTFCNTMTAYKENTTIMNSTTNTNREFHKEESSTYWLPKDEEEQMRLTGQHYAFKSLFEGNVLPSVTDTLDFQKGINILDVGCGSGVWIMDMVQEYPNCTYHGCDIVNILYKNVDVKQFTFSKGNVIKGLPYEDNTFDFVHMRFLVLALREDEWPMAIKELIRVTKPGGMTPKDPSNLSYLISTAFRDTCKAKGQNACMGAELENILSKFDGINITQSECRLCDTSSGTNTAKLFIWDALENMITQNVNTAAVDPTFFDTKQEFHNDETSGYWLPKGEEEQKRLTAQHFAIKSLYGRNVMPSVTETLDLEGGITILDVGCSSGAWIMVSEYPNCIYHGCDIVDVTYKNVDVKQFTFSLGNVTNRLPYEDNAFDFVHMRLFVACLRKDEWPVAISEVIRVTKPGGMIQLGEFDLQPQNDSSSLYYRILSCFKDACKSRGQDPDIGSKLEMMLSKYSNVKVVESDRRTCDMSSGTPTAKMFIWDNLEVIKSMRRVLGPMLGIHNQKDLISFLEEYKHDLETKESVVGFAAVTVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZT2</accession>
    <name>A0A367JZT2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glycine hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SHM2</name>
        <name evidence="11" type="ORF">CU097_001311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000470">
        <property type="protein sequence ID" value="RCH95407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZT2"/>
    <dbReference type="STRING" id="86630.A0A367JZT2"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH95407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="338" mass="36886" checksum="8473B95C30ED7CA4" modified="2018-11-07" version="1">MGLDLPSGGHLTHGYQTAKKKISSSSIYFTSMPYQVNPSTGLIDYKRLEENAALFRPQLLICGASAYPAEWEYDTMRKIADQHGAYLMCDMAHISGLIAGKEALSPFDYCDIVTTTTHKTLRGPRAGLVFFRRDKGDGLESRVNQAVFPSCQGGPHNNTIAAVAVALKQAASPEFKLYAKQVRANAKKLAEVLTGYGYKLATGTTVNHLILWDLKPQKLTGSKVERICDMVHITINKNSIAGDKSAVTPGGVRLGTSALTSRSLKEDDFVKVGEFLHRTVQIALAVQEKCGSKLMKDFVAALEGNEEIAQLKKEVIEFARSFPMPGFDPSQIKATVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K063</accession>
    <name>A0A367K063_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000481">
        <property type="protein sequence ID" value="RCH95291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K063"/>
    <dbReference type="OrthoDB" id="2306559at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17563" checksum="68E088470BB1AB90" modified="2018-11-07" version="1">MSGVQIRATYERHLDEGAGVVTIGYARKSYENEAMSIRGRWLWMLKEHYHVPINLKAACERHVEEEADVVTIGYTRKSYGYESMTTHARLIQSQVDSLRGRYLARKVSVSSRCNASIPLEDRGKKQGDSMVKIGQIENCAGTMQDLVHRLRTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0T7</accession>
    <name>A0A367K0T7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000459">
        <property type="protein sequence ID" value="RCH95511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0T7"/>
    <dbReference type="OrthoDB" id="2290660at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25553" checksum="A20C428E5DBA3327" modified="2018-11-07" version="1" fragment="single">YGEQMFDLVCKNGVKISTRAMALNEKQMYLDLYLIWIVLCLRPGLVNCILTGVSLKTTSATATSISSKQSAVIPSLSEESQPKEKRLKDLKEEITTLNAQLLKKKEAFSLEKIDKEIRKMKKERNGMVDKDGQVLRQELKALRREEYTCRNVCAKTYYYSLRYTSRKQHSDDSVDLPTELKQTRFSGTDYGLKTMSVTVPISMKMFNTHLNLYNKFHPDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1Q9</accession>
    <name>A0A367K1Q9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_003631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000427">
        <property type="protein sequence ID" value="RCH95831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1Q9"/>
    <dbReference type="STRING" id="86630.A0A367K1Q9"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="155"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="277"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH95831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="46341" checksum="E81CF55241F727B2" modified="2018-11-07" version="1">MESFQFSSYADEYTQLLTELHEAYCKDQPEDVLQYCSNFFNKKLEEQRSMYFRQQHNPFLETERHPLADTDDYPTRDRAYSSFTVTTTTTSIDGELDDNFSIEPLSMQPNYNRGRRTSVSAESMAPAGNKFVKKIIPKTEAQMERIRNSVGNNFLFKNLDEEHHQDVVNAMMEMTVEEGKTIIEQGAVGDYFYIVDSGTFDCFITKDGKTDKVTSYETGGSFGELALMYNAPRAATIVATSDAKVWALDRVTFRTILMENTSLKRKMYESFLAEVPLLKSLESYERHKIADALESVYFQDKEQVMKQGDIGDQFYLIESGTAVFYKTDKNGEQQEVNQLGRGSYFGELALLNDSPRAATVIAKGRLKCATLNKKAFTRLLGPVHEILKRNSENYYAIINQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1T1</accession>
    <name>A0A367K1T1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000401">
        <property type="protein sequence ID" value="RCH96107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1T1"/>
    <dbReference type="STRING" id="86630.A0A367K1T1"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925789" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="244" mass="24441" checksum="B330BCFD259CB847" modified="2018-11-07" version="1">MVSVKTFIATSAALIAAFVNVEAAVAPTYPSPGTIQVQGQSYDITWTFDGKNASETYQIDFMTGSNLEQKKLATVATGVPANLLKYPFVAPQVSPNSAIYFFMFTGSQGDQAWTTRFGIVAANGDKLTPEPQQTQPSGEKIPWGDGKLLTAISGNNSSASSAPAAAASSSAPVVVAAASSAAPSSSSAPIVVAAAATSNSPASVPSAVTSAAPSSAAQKSASAGSMIKPALSLIAVGAAGYMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K279</accession>
    <name>A0A367K279_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type I HSP40 co-chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">YDJ1_3</name>
        <name evidence="9" type="ORF">CU097_009582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000384">
        <property type="protein sequence ID" value="RCH96276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K279"/>
    <dbReference type="STRING" id="86630.A0A367K279"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="407" mass="44978" checksum="2EF4E06F223EF61B" modified="2018-11-07" version="1">MVADTKFYDILGVSPNATDSELKKAYRKLALKYHPDKNPDAGDKFKEISHAYEILSDPEKREIYNQYGEEGLNGQGGMGGMNAEDLFSQLFGGGGFFGGGSRRGPQGPRRGKDMVHQLKVSLEDLYLGKTSKLALQKNVLCNKCDGKGGKEGAVQACKGCNGQGIRIMMRQMGPMIQQVQQACPECRGTGEVINEKDRCKQCLGKKIVTERKILEVHIQRGMRGGQKITFSGEGDQAPGIIPGDIIIVLEEKPHPRFIRKGDDLVYEAKIDLLTALAGGQFAIPHLDDRVLLVNVIPGETIQPDMVKVIPHEGMPIHRVDNRGHLFVKFTVEFPQSNWTDEETIKKLETILPPRPALPTFQDKHTDDVVLVDAEGYQARNSGSSHAYQEDDDDDDHHHGPGVQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2U7</accession>
    <name>A0A367K2U7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000364">
        <property type="protein sequence ID" value="RCH96486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2U7"/>
    <dbReference type="STRING" id="86630.A0A367K2U7"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="41"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="359" mass="42414" checksum="3029CB45102F047E" modified="2018-11-07" version="1">MSSSINSRNLCVVTNGDSYPGYISSYRILCAMKKREDRFANECKLRVLCRDKESHRMRLLKEMGAEVVKVDYRDENKLREMMKDAAHVCLIPEHSRECVEEAQCVIKAAKHQGVEHISMHSVVGCDRASEHSSGEEQKYRHLAQYHQIEKMVKEQFGNNHCIVRICLFNQMFYFMAPQIEGEGILALPVKEDAKWGCIDLNDWVNAIYNLALKEHEKRGRTIGSTGKKQLYQFTPQRVMSSKEITREIGEGLGSQELRYKRISDDEMRQYLQKMKDDERFREEPKHEKEPKWDQDGPWSYPIGRYLNDHLIELILEYWRMANDGKQEIHTNDLKEVLEIEPRSVKDYFHKNRNQFREFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K374</accession>
    <name>A0A367K374_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitotic spindle checkpoint protein Bub3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000378">
        <property type="protein sequence ID" value="RCH96331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K374"/>
    <dbReference type="STRING" id="86630.A0A367K374"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37104" checksum="F44902FBA9EA6066" modified="2018-11-07" version="1">MNDPNQFELAEPPLDGITNICFNQEDPKYLLASSWDKTLRLYDTAANHLVCKFENEAALLDCCFMNDSVAFSGGVDHKVKKYDLNTKTDIVLGEHGGGVRCVEWSSLTNCLYTGSWDTTLQLWDPRSQESQQKVVLPNKVFSMDLLNNTLAVAMADRHIHIYDTRNMKEPWQVRDTTLKYMLKCIRLMPRAEGFACSSIEGRVALEFFEPVREDKRYAFKLHRQTINDTEVVYPVNALAFHPIYGTFASGGSDCIVNVWDGVNRKRVKQLPGYPDEIASLAFNRDGSVLAIASSYTFDEGERDHAPDTIFIRQMQDVEVRPRVINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3T9</accession>
    <name>A0A367K3T9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicular-fusion protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_012704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000335">
        <property type="protein sequence ID" value="RCH96805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3T9"/>
    <dbReference type="STRING" id="86630.A0A367K3T9"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH96805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32885" checksum="E3363E436C71B9BF" modified="2018-11-07" version="1">MADYEQQANNLINEAQKKLNSWKIFSFFGPSNKYEEVAEIYEKAGNMYKLAQQWQKAGDAFTEAAKLFQRGNCAKFEGSRAYDNAAKSYKRMDAKAAVGALKEAIILDQEGGNFRSAAKHYQDIAELYESDIASPQDAYEAYQKAADLYNADDSPALANKCLLKVAQFAADLKLYQVAIEKYEQVASAAVDDPLLKWSLKDYFFRAGLCHLLTGDMVKTTQALANYCNMDVSFESTREYGLLKGIIECIDEGDVDRFTQLVFDYDKLSRLDPWKTAVLLEIKKTIESEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Z0</accession>
    <name>A0A367K3Z0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000327">
        <property type="protein sequence ID" value="RCH96897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Z0"/>
    <dbReference type="STRING" id="86630.A0A367K3Z0"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017058665" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="18535" checksum="3C5AB06AD89D9A4A" modified="2018-11-07" version="1">MSLRTLTLILSAVILAAFLHTVTAAPTSSDINTILNAHNKVRAKHHAPALKWSTKLATYAQNWSNRCQFQHSSGPYGENLALGYPDWNSVVNGWYSEVKNYNYNNPGFASNTGHFTQVVWKATTEIGCGVKVCNNLGQGAKLYTCSYYVPGNMVGDNGKYFTQNVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5L5</accession>
    <name>A0A367K5L5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000272">
        <property type="protein sequence ID" value="RCH97504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5L5"/>
    <dbReference type="STRING" id="86630.A0A367K5L5"/>
    <dbReference type="OrthoDB" id="2246061at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016677689" evidence="1">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="25444" checksum="FEA21412C8475FD7" modified="2018-11-07" version="1">MLISTLLLVYCFTFIYAAPIFSEQNNDIGSVLTDTLSDFYENIIDQVMLDASEDILRYIPESMSQGNIEARHDIIRSMDRNLNFMRASLLASVNPLVSTDIQQLMIKNDVDTLQNELPKLNTKISHQLGLIINAEQTSAILIRQASSIVHKNTKSSSTVTVEWKLRQPFQVNIIHQEQEQVFDASNELQWLFTRLSQVQSDLLTEFNDHVQNAVELLMETLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5S9</accession>
    <name>A0A367K5S9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000266">
        <property type="protein sequence ID" value="RCH97573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5S9"/>
    <dbReference type="STRING" id="86630.A0A367K5S9"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="747"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="799"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="913" mass="103271" checksum="749BF28B45296B9D" modified="2018-11-07" version="1">MVCKDLNNNKPTTVLSYVERSLNHIDEFGENVKVFWKPDMTYIAIQTSKNYLLLYSILSYEQQSFEFNFPNPTHAVMAGPGEGKGPKTMLLKFRLTIRVDAGIICGTSLDDTLVIATCSPPAIQCISWNPQQANATQSSLLSKIDFFDSNDQLSYITYEKGLNIFVWLSTNGKAYLTQMKNNHSQKKGTTAISEHKTQWVGTCFHGKEDILAEDKATSVSINSTFSLIAVGTTGGTVYVYSVENYNAPPVFSHKLQLMSWKSSTGSVTSLAWTSDGHALSVGYESHGLAVWSVYGSMLCATNELDEIANEENLKDTYIKGIQYLFWGPGNYSLYVLAKCKADENIMYTLPFVKSALTSYLHSDNAKKGLLQMDDRMLMYNSSGDYQDESTTIDPAAVAWTHIQYPAMYIADNWPICYSSISSDGSYIAIAGKRGFAHYNTISSRWKLFGNQQQEQSFLVRGGMVWYKTILIVSCENVQQKTYEIRLYSRDNNLDHSQVLYTEPLSTMPVYMTLCGNFLLVYTTENIAIKFCKAGTSQKHQPISYISWRSIDSVISSNITLLIGGKLLILSSNDKTDESTEKEPSPIPFDTHIISDKTEYYWIGKKGIENLRTSLWIMNGKGLRVLTNFLLPEEFDITSNHYSESEPSTPTTPGHLSPGFDIGRPFLLGYHIDDEEDSLPSSEMRTRWKIDDFEGLKDQAIDMPLDFYPISILIEKGIIIGVEQSISYNALLGFALFKMSPKMHLFLHHIFRYLLQIDLEEDAVTFAKAYEKFTYFSHVLEILLHTVLEEEAGRNMTDGKKTEVALWDYLFSVVGKPKDLFEICLEEGRLHTATSYLIILQTMQPLTVAEQDTMRLLHKAMDEDNYELCKELVRFLSSIDNTGKALYEALQMIKSHIDNNTNDNQMDKMKAKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K617</accession>
    <name>A0A367K617_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="8">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GNPDA1_4</name>
        <name evidence="10" type="ORF">CU097_014939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000256">
        <property type="protein sequence ID" value="RCH97702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K617"/>
    <dbReference type="STRING" id="86630.A0A367K617"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000004">
        <property type="entry name" value="Glucosamine-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="33301" checksum="B283E4604A7D15B6" modified="2018-11-07" version="1">MRLIIREDYEEVTSYVANYVKERINQFNPSASRPFVLGLPTGSSPVGVYKKLVEMYKAGEISFKHVVTFNMDEYVGLPRDHPESYHSFMWKHLFMHVDINPENVHILDGNAPDLDEECKKFEAEITKVGGIELFLGGIGPDGHIAFNEPGSSLTSRTRVKTLAYETIIANARFFDGDVSKVPKLALTVGVATVMDAREVLIIITGAHKAIALANCIEGGVNHMWTVSAIQMHPKGLIVCDEDATLELHVKTVKYFKSIEHVHQSLIGPENLSLQGGVKQLKKFNYSSRSQTPLNGPYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K750</accession>
    <name>A0A367K750_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000235">
        <property type="protein sequence ID" value="RCH97959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K750"/>
    <dbReference type="STRING" id="86630.A0A367K750"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58602" checksum="004A2EC8CE3421CA" modified="2018-11-07" version="1">MDIEKIKQNATVLIPTGVALLSAIYLLTRGKSNEGKGLKEIPYPPRSIRWPIFGHMLSMGKVPSKQITQWHKEAGPIYKIDMGNQLWIMISDPLLAHDIFVKAGKSTSSRSYHRFNVEIYGRNNRGIVFVQYDPQWKNKRKAAASLLSPGSVDKYGEILEVEADRMMSRLTKIADEGIAINPFKQVQLTSLNIILTLAVAARCNDVDDPIFLGISSYIHQAMIYSGAAGDLGSFVPSLAWAERLRGTEKKLREFVETKRDPIYGMLIQEALKKEQDSLAKSMYEMKEQGLVDEDDIHVFMSDLIGAGADTVAVSLYWTFAILAQKPEVQKKIIDELEAWKAKNPAGAIPNFHKDREEFPYAICVQKEVMRFRPVTNFGVPHMASEDVIVNDYLIPKGSVLVSSMAAMHMNEKFYENPTEFKPERFMSNTSRMGIAANTKIEDRDQFGFGWGRRICPGIHLAEVELFNFYVRFFDRFIIEPELDAQGKPVPIDLDDYSDEGIIVKPAPYKIRIVHRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7B2</accession>
    <name>A0A367K7B2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000227">
        <property type="protein sequence ID" value="RCH98058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7B2"/>
    <dbReference type="STRING" id="86630.A0A367K7B2"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="11162" checksum="7C9522FDB3B3FFF3" modified="2018-11-07" version="1">MVESGSKPPSREERKRCWFLRDQYFQCLDRCNIRDPATVEKTPEKAPECLELKKNYEEGCMASWVEYFNKRRVLDMRQKEYLKFSEEQSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7H6</accession>
    <name>A0A367K7H6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AMDHD2</name>
        <name evidence="14" type="ORF">CU097_014789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="EMBL" id="PJQL01000217">
        <property type="protein sequence ID" value="RCH98183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7H6"/>
    <dbReference type="STRING" id="86630.A0A367K7H6"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="13">
        <location>
            <begin position="57"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="352"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH98183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="430" mass="46346" checksum="DB8923B4B46412CB" modified="2018-11-07" version="1">MASDKIYKIINARILLNHEIVTDSYLWYQNGKIIHPQNLFFSARRDADEIIDAQGLLVVPGFIDTQINGAYGIDFADHDEPVEVIEQNISKVAKGLLKYGCTAFCPTVVSSCPEVYEKVLPLLNNRPGSASAGATILGAHVEGPFISYEKKGAHNPGVFKDAKRGIEDLDEAYGSQLKKGSDAVRIITLAPEIEGICNAIPDLVKRNIVVSMGHSACKIAQAEEAVTKGASSITHLFNAMQAFHHRDPGLIGVLGAADLPIPATSSRHPEASATSPDRQRPDPRPFYGLICDGVHVHPNSIRIAYYSHPTGAVLVTDTLSAMGLPKGVYILGGSEVEVDEKGGAYIKGTRTLAGSTITIDQCIRNFKKFTNCSIVEAVEAATLHPARMLGIDNQKGTLNVGADADFVFLDDSNDDIQVKRVFIAGEEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7Z5</accession>
    <name>A0A367K7Z5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000208">
        <property type="protein sequence ID" value="RCH98296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7Z5"/>
    <dbReference type="OrthoDB" id="2290632at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="23517" checksum="107FD72319E3AAD9" modified="2018-11-07" version="1">MQSIYDQSYSSTPLYRTQKTIHKKKSKKIILGRPSSKEKMTVEELKALSRQVKLPAKEETDDIVSISRHLRHNLNKAKYKMMDNLRQSNSEIYEYLLKNDSKMSCPSLSDDDCSSVSSNNTIEPVPPVITVNDIANLCSILYTPIYSSMLDLNLLLRQQSTVESHQENLEITEDQINSWLQRGGGGTISSIPSLATDQELADLLDFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K999</accession>
    <name>A0A367K999_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_014557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000199">
        <property type="protein sequence ID" value="RCH98411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K999"/>
    <dbReference type="STRING" id="86630.A0A367K999"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH98411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="231" mass="27340" checksum="347C25D162FC6EF4" modified="2018-11-07" version="1">MSKADFDLCERQYQCEYCLKSFYRLEHKVRHVRTHTGEKPHQCTFPQCDKRFSRSDELSRHYRIHTSPPTILLQRRRKIRRLSSNKCRSMDDEEAYLKQQQHCSILRFLPSSNEQGTQMMTRNRSSPYRQSTNATLHHCPAVNCSKSFWRKGQLVRHFQKHHPDHHEEQQPPSPSSSSQSSDDNSASWSPLEMHVYLPPLDTKLTQSVMWDNQPCRLPSIKDLLQPENAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9L6</accession>
    <name>A0A367K9L6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000160">
        <property type="protein sequence ID" value="RCH98923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9L6"/>
    <dbReference type="OrthoDB" id="10289725at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38083" checksum="F2F10BAAB1CFF329" modified="2018-11-07" version="1">MIIHAGGTTRHHHEYSTVENSKFSEYVLKIPKHSVRLTCSPQNACSLLEMTRPKELQMQMKYNTEYASFTPLLFETTTRPLTIEMNSDKPTRLMSACSLQRSVLKEIWKGCKNSVEKLHFSTGAEMYEYISFNDEKSKWLEDILRNCQKLNTLHLTCVNLDPPASEVVRKKLINPSVENLSLKIIRYEQKVLTQYLSLLPSLKSFKLISYIQITGKRDNVFDIKIPHAALEKLDVDLSFFWDKSCYLWKSSSKESPQNLRIKAVLLHVFPKKGLKRSFVLKNLRGKLTVKEGTSLPKSSYSVTLRVYCKSLQIISTSIGAVDIKNHPLYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAR0</accession>
    <name>A0A367KAR0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPF2_1</name>
        <name evidence="7" type="ORF">CU097_002773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000131">
        <property type="protein sequence ID" value="RCH99304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAR0"/>
    <dbReference type="STRING" id="86630.A0A367KAR0"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="305" mass="34968" checksum="94B53B3F78432962" modified="2018-11-07" version="1">MLRTVKPKNARSKRFLKNREAKVHENPKNTLIIKGSTTSQVINDALKDLYALKRPNAIHFSKKNEIKPFEDEQKLEFFSTKNDCALLVIGTHSKKRPHNLTFVRMFNHQLLDMYELGIENAQCMGSIPGPKCSLGLKPLMIFNGEKFDTDTTYKHLKSFFLDFFNGEVTSAINLAGLEHVISITATPDDNRILFRTYLVQMKKSGVKTPRVELEDMGPHYDFVIKRTSLPKSEMWSQAVKVPKELKPKKVKNLEKDEMGDTYGRIHLGKQDFNKIQTRKMKGLKKRAGEDEDEDEDASPAKKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAU4</accession>
    <name>A0A367KAU4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000130">
        <property type="protein sequence ID" value="RCH99335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAU4"/>
    <dbReference type="STRING" id="86630.A0A367KAU4"/>
    <dbReference type="OrthoDB" id="2264488at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016752200" evidence="1">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="14716" checksum="AAB29453B0BA9CB7" modified="2018-11-07" version="1">MLTNKLPRSAIFTILSFFRSLWLSCPAGPIFGCYPVNSSPSSVLVCLLTTVDLMTSQASDSFCQNLRKSTPLTQGLTDESDVLFFRFCPVLPAALKDEAFELLHANPTTGYMGTARTIQRFSRLFYLPNLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB07</accession>
    <name>A0A367KB07_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000125">
        <property type="protein sequence ID" value="RCH99412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB07"/>
    <dbReference type="STRING" id="86630.A0A367KB07"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="59" mass="6649" checksum="20FB90EF73C84960" modified="2018-11-07" version="1">MSTFSPFRQFIRIARMTTTSESKKPLLALPATAEETVQTIGVNDTFKLKELGPVGWYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBK4</accession>
    <name>A0A367KBK4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000138">
        <property type="protein sequence ID" value="RCH99221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBK4"/>
    <dbReference type="STRING" id="86630.A0A367KBK4"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="370"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="558"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="665" mass="75959" checksum="D00859EFCABD0E6D" modified="2018-11-07" version="1">MLSMGSIANRRMKLQQQQQQQQQKPESASSQSQPKSLSFITPIEPKQLNDLLNDYKQKPKSLLILDVRSFVQFSHSRIHNSVNVSIPNTILKRPTFTLDKVYEAIVLEDAREKLRSWQTADYIIFYDQQSQQLQENSACAYLSIKLVNSGFKGKLHYLKGGFDAFSEQHNDQIESNPTSPTYGSANNTMPIGPPTTIGGSSGFALNLNSTGSRRPGLRLNNLPMATPSIGPFTAPMPQFENQAFNPFFSNIRQNMELSHGPIRERFPVRLPPKCYVDPQNEDCIQVDRTPRCIAGGHMDPEHSNCFRAPTWLQNIIKEQGPKVLAESYEKLERTEQRRLQNIMHFHSKHTSNPSEFPFSIVAGIEMGALNRYTNIWPYEYTRVKIKEHQSSDYINASYLQYIDCEDAISDARPETVDTHCIKAMTDHKSSSTSPYRRYISTQGPLPATFNDFWQVVWEQDSRVLVMLTKEEEMNKIKCHRYWPSKINEPVQYGQVTVTLVSETVRPVKGLDESNKNEDDTIIVRQLTLSRGESSRTISHLQYTGWMDFGVPDNPLGTLQIIQMADEAQKQYSASNQQVGPMIVHCSAGCGRSGAFCAIDTVIYRLCNTDCNPKSDILLETISRFREQRLSMVQTLRQLVFCYEAIWWWLLNYTQPLSIDDMDTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC73</accession>
    <name>A0A367KC73_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_003319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000105">
        <property type="protein sequence ID" value="RCH99699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC73"/>
    <dbReference type="STRING" id="86630.A0A367KC73"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="338" mass="36328" checksum="1329C69E02A989E5" modified="2018-11-07" version="1">MGKKRKTKQIRPWCWYCEKDFEDDKVLVTHQRAKHFKCEVCSKKLTTAGGMVVHAQQVHKIEIYKVPNALPGRDNLDIEIFGMEGIPEEDLVAHELKVAGLNNSKKAKTSTGGSGQYSELTLEEIQAQMAAHKATANPNLTTTTTSNITTSAAPTSATITAAPAKPAAATVAAAPPQYYYGQPYGDYYNQYYANYYGAPGGYPYGYPQAPYPATEYPAYGTMPVPGAPPMPPTGMTPPVPNTSASSDATQANTISTATPISSSPPPQPQAAALPSTTTTTTTVETSPPSGHETQNATTDSTTGFTTTKKKATKVVLIFNNQDYSAEEQRALLDKYRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCI5</accession>
    <name>A0A367KCI5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tip elongation aberrant protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000090">
        <property type="protein sequence ID" value="RCH99934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCI5"/>
    <dbReference type="STRING" id="86630.A0A367KCI5"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF492">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51271" checksum="09F600E654878FFD" modified="2018-11-07" version="1">MSQHRLPTSPSVSSSRSSSFTRVYQRPESPTLPPENEGRSTRSYVDYHDNPTSPSHPTRSMPDIGTATIHETSTFQETKSRTRSKSRPSASNSTTSSRTSRTKSTKLHKTPDHLATAIEISTTNAISSPAPAAGMYWSRTLTYGKGPSRPLRAHTANLIGDRLFVFGGCDTSSCFNTLYILDMGRYKAMLLDMIIYGPPPCRAHSCTVVEKDLGYGKKSHQLYFFGGGNGPDYFQDVYVLDAETLTWSKPDIDPQSRPSKRRAHTSCLWENKLVIIGGGDGARALDDVYMLDISKQGQLRWEKLETTGRCPPARGYHTSNLVKDKLVVFGGSDGHDCFEDIHVLDLKSAKWSQIELDKKIPRLAHTSTQVGSYVFVIGGHDGRRYSQEVLLFNLVTMSWESRKIYGVAPNPRGYHTTVLYDSRLYVLGGYDGKNVFDDVHMLELSACAYLPQITNFEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCQ4</accession>
    <name>A0A367KCQ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000086">
        <property type="protein sequence ID" value="RCI00005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCQ4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802118" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="11296" checksum="CCE37DCFC5AA3C8A" modified="2018-11-07" version="1">MQIKLVNLTICASLAAIGFATPAPGVEIAHSAFDVNGAPGDINGGAEAISLDDFADMQDEGSIPETAETLLRRSFSFSLAYIACKRIRPRLVKHSSSLKKAHNVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCX4</accession>
    <name>A0A367KCX4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000083">
        <property type="protein sequence ID" value="RCI00056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCX4"/>
    <dbReference type="STRING" id="86630.A0A367KCX4"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="385" mass="43585" checksum="CC1D2DBFB8B7FCC8" modified="2018-11-07" version="1">MQKQKHLQQRPTTASPAPPTLNVSSSSHSDSFRHGDSDTSLFEKSSKQTTTTIKDSIIDASQTILFTTTSLKRTVGRCISYTDNDNLQATFTPILTKAKAATERLGQILDLIEDDKETVHNLIQSTAQCISALKELCYILTTRLSIIVQGLDSKFSRHLLIHLYSATVDIKEAWQIISPYLTIDPLSIVSNKASSFRNRSDSEAHSPFVSPLCSPYRDNKQLYTCLKNAVTGSFHVLNTLQQSIEETLNSSVIPSLERKLKELLRQAQYVTDLAHKLDKSIDSRINKDEYFVNKQQNRKFWEDTSIYLKAMVSLMTLIRSISKEEDFVWPRTVKQGCLYVTRITAEVAKLWNNSSTFAQDGFFLGKTERSTSISEQDIPMPRRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD94</accession>
    <name>A0A367KD94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L27A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL27A_5</name>
        <name evidence="7" type="ORF">CU097_013377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000099">
        <property type="protein sequence ID" value="RCH99801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD94"/>
    <dbReference type="STRING" id="86630.A0A367KD94"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="306"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="43247" checksum="1C2B3F10EE9647F6" modified="2018-11-07" version="1">MNVQQAFNYFYLLEKQFWSKLDKDMIKYVTFDGELSPEDMLLYGEFGFTLLELKPCTLVEFRDAQVTRLYCEQVVVPALHSLEEKTLDYFIITNRVKTPESDLQGALLIYHKDHQGIIATFDHDTTVPEERMAEILDYPGHLPSSEQEVSTMKTVIYLHDRKATQVVLTTFAIQTHQTDAMISHFQRYKHACKERLDIDLSLIVQDDEEIINSKAARPLQHRQDQSLPLFHSPEMPTRLHHNRKKRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRHFHLKKNPLWRPVINLDKIWTLAGEGVREKYKNTEKVPVIDTLQHGYAKVLAKGTISQPVIVRTRYVSALAEKKIKEAGGGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDY2</accession>
    <name>A0A367KDY2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein Rho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RHO1_5</name>
        <name evidence="10" type="ORF">CU097_014569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000083">
        <property type="protein sequence ID" value="RCI00052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDY2"/>
    <dbReference type="STRING" id="86630.A0A367KDY2"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="198" mass="21888" checksum="4D85C1461FD73D6A" modified="2018-11-07" version="1">MTMNDIRAKLVIVGDGACGKTCLLIVFARGTFPEAYIPTVFESYVADIEVDGKNVELALWDTAGQEDYDRLRPLSYPDSHVILVCFSIDSPDTLDNVQEKWISEVLHFCPGIPFLLVGTKKDLRDDPAKIEELRKTNQKPVTTDEGRDVARKIGAHMYIETSAKTGEGVQETFQQAARAALNIRKATGKKGKGKCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDY9</accession>
    <name>A0A367KDY9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000063">
        <property type="protein sequence ID" value="RCI00387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDY9"/>
    <dbReference type="OrthoDB" id="2289105at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="374" mass="42751" checksum="9F741A4959500078" modified="2018-11-07" version="1">MNCMKTRQEQEQEQERSENEGQDSDHNNAHVNIQPPTTVRIDKIADTITNHGELNRPLPFIDISNNATVIPITSTTPLASISVNKGSNRYIFDSPCTSTERPHMPKVRKGELETLNQVFVFGTQYCVSDPLCKTEYNNNKEHQINSSSLRSLGLLDDLVFLLRKVPCDGFLNQVWNWKGDPKIDDQGKNFLIVCKHILLTFHLVHRTPPMHVMNHEGSFFCESILPGLLALSKIIKFVEFKCGMVKEHTTHSLENSVKILECNVAALREKACHYENASLETFKKIGAYGIQIIKTQVTLGKTMIHDKHRRKSIEMRSAQIPRTWDDRLLILEYLELLATLYIELLHAQEVESKLLEERVNVDRPSGPLVRSIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE53</accession>
    <name>A0A367KE53_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60s acidic ribosomal protein P2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">60S_2</name>
        <name evidence="6" type="ORF">CU097_011264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000079">
        <property type="protein sequence ID" value="RCI00122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE53"/>
    <dbReference type="STRING" id="86630.A0A367KE53"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="10852" checksum="AA3F68959B326FA3" modified="2018-11-07" version="1">MKHLAAYLLLVAGGKTNPSNEDIKKLLASVGIETDAARLDALLKSLEGKTIAEVIAEGTPKLASISAGPVAAAGGAAAGGAAAEEAPAEEKAEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEB0</accession>
    <name>A0A367KEB0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_015453</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000054">
        <property type="protein sequence ID" value="RCI00555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEB0"/>
    <dbReference type="STRING" id="86630.A0A367KEB0"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="12">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="599" mass="67867" checksum="364AFB2C08D92ACA" modified="2018-11-07" version="1">MSSKEQETTTLFTKLKNAIDSEDDQQALELCDQLLKLTPDDKIVLQSKVISLIRLEKYRDALTLIARQFRNTKELAYEKIYCYYRTNQFAPAMELLEELSSSNQSPSLLYLEAQLLYSQGQFKKAVKVYESLLQTLDKKDVLYDEIQVNLLAAKAGLLFSTYQSKEIDPVKERSEDLYEVAYNAASVYLAQGNIPKAQEQLELAQKQCMDKSSTMSEEEQEQELAVITTQLGYTYQLQGRTSEAIQIYQSVLNSKDTSIAAVASNNIVVIDQAKDIEDAAKKLKFATSKEADAKLKNYQKRVILMNESLLHLYAKKYATCRDQAQKLIDKYPDNDSLYLVLASTTYHQHKASKAIEELKKYAEKKPTSLAIHFAAIQLQMLESQHRDALETLQHYLNGVADNKQEQYRPAIVALLVWLYQQTGQPEKAMETLDKAASIWKSDDSFASTHTPTSIVKQTAAFKLKAGRLQEAVEDYEQLVKEDPTDAQAVAGLIAAYAQVDPTKAEQYGSALPEIALNHIDVDTLEKIVPGVKRGYVKKDPNGTFVKKPKQKKKRKPLLPKKMDPKSQPDPERWLPKQERSNFRAKSKSKKTAKSSTRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF55</accession>
    <name>A0A367KF55_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000037">
        <property type="protein sequence ID" value="RCI00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF55"/>
    <dbReference type="STRING" id="86630.A0A367KF55"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49871" checksum="C5260D4CD7C1F4BF" modified="2018-11-07" version="1">MMMDQISVDRRSFIEENQEKIMQEYEYHRDRMFIQDQRKRNQQQPLYFDEYLGVYKHAVSKKRQSMKPLYSSPAVSTISLLSIHHDRPWPIPENVAQVHYLFKKARSIRDPSRQLSLCKTLMAIKTDNKELHQTIQLETQKLLKELSTGVLRVTEAQKLLASCFGVGGLGLPCDRERAFLLYLQGSKQNDPESNYRVGVCYELGIGTRRDYTRAVAFYRRAATLSHVAAMYKLSIILLKGYYQQVINVREGIAQLQRAVSLATEKIPHPLHALALLIISNEFSDHLICDTGYALELLHQAAKLNYLPSQAKLGELYETGKLVQQVDEAKSIYWYSRAAEGGSAEAALALSCWYLTGSSNILEQSDRQAYLWARKAASTANIDRWTLAKAYYLVGIYIEKGIGTVEEEDPQLWFQRSAILGHKGAMEKLKQEEHSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG18</accession>
    <name>A0A367KG18_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000022">
        <property type="protein sequence ID" value="RCI01166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG18"/>
    <dbReference type="STRING" id="86630.A0A367KG18"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="255"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1017" mass="116042" checksum="5001D6A5CB470727" modified="2018-11-07" version="1">MLQELSDLDFDAYFEVANSNQQNNNRDILYHEDQQQNRQQQSRQEDQNESNNSMLPSISSPTNNNNNRYYSSPLQHNTQQQQQQSNFLFNWGLQQQQQQQRQTHISPSSSPLSSSDGYTSHSLSPPMSSPPLYSINAIKDEANKALAGFFSNNKKCLYTLNHDVPGINIPTTPMNDISPQQAMSTTHTELPSPPLDVPVANFSSMNQWCQFKSPVHPLDEDEDDKDDKHWRKTTRQATIRTINDPNLIHAPGKQLKKVAHNAIERRYRNNINDRIRELKNVVPALYKARVSSGSAHHHDKDDDNSSTDSETEIVDGVEVAKKLNKATILRKATEYIQFLKTSNERVDKENLILQQIIAQMPGGQEVLSRFLYQKSEFEKAENERLARERREAQERERIERQKLLRERAAQRAALAQLLPKPERRPYRRRQSKKTSSKKSSSSEDETSPNNKVFMAAFMCLAFFTTAPSSSPIPHEPQGGFTDFGNTSTSSTYYRILYNTTFLDIWPIARYVIYAFGLFYLLLLPLALRWLRPRPVKRPKKCLDHCHYASEVPTAWSRLYINLVQLVGKSSPTIILKHRYDLHSILLTLVDITRDLVYLLVPQFMLQFLHRNSKPSGCPEELSRIGAWIRLNEVECLGGNPDISRLSMLHSSLGMLAQLHKMKRDKDYVTYCGHNTIARVHASIALQLELCLPPWIASHVVPAQWQKVIDCLNSKNEDEVITHQFLKSECHTQILHMLNARNGFNHGAYFFPEDPTQSGSDNCRNVFYSFVLPYVTSPLDLVLYWQQLARLENCWLEYLDGVRPVFSDKQLNQALSVSATTTAPGHMLQWWVRVGLALESLAKDQQDNMDILVEYTRVKGAAINSHPSSNLLRRHQSMICHLLEAACALVQNTRLERVPMLLEQASKDRFASSECIRQIASTDSIPSSNYEASVLVLSTLAVHLRTLKALIIHQSSTSRRQSISAPPSFSASQASTYIAQLRDQVLQDLDSPYAKSLAGKCRKHIQSYIYQADDTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGJ6</accession>
    <name>A0A367KGJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000014">
        <property type="protein sequence ID" value="RCI01345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGJ6"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016594770" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16082" checksum="BEC3A027FF738C2A" modified="2018-11-07" version="1">MYKSIALVAILALFLQQVLAQATCTDPVNFNACMDIQQKKLGTCGPVDYGCQCEARRLIVECYNLCPQRDAEKSIDSASMQGICVAVPSSSSASLPAATSSVSAPVASNAAPSAAASSSSSAKPSTSATTTTSSASHTQPLAVFMIICMAIGFYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHB5</accession>
    <name>A0A367KHB5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000006">
        <property type="protein sequence ID" value="RCI01531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHB5"/>
    <dbReference type="STRING" id="86630.A0A367KHB5"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="391" mass="45398" checksum="87F730F41F01A7C8" modified="2018-11-07" version="1">MNDRHCHNTEEQDPAESEQVYLIKVITAFASYKRFSLNNNHRRRRDYLSLPEHHKKLIPDFLDKVNKVDECIEHNMTFIRDIVKSANMFLDPSIMEHSQQKLYSSMRNSNRPPVSPMDMDKVRSTLKQFVRDWSKQGERERKLTYDPIIQELNTLYQHVPADKRGDIRVLVPGAGLGRLAFDIASQGIYYAHINAFDRDLFTFFPNQQDLAVKLFGSHFILNRVKEVNEYSIYPFIHSYSNIKSDLDQLSPIKVPDVLPAHLPSTVDFSMVAGDFVEVYGQQENNFEAWDVVVTCFFIDTAKNILEYLEVIHKILKPHGTWINIGPLLYHFEDSSTGDTSIEISLEQVKDVAKKMGFEFKKESMVSTTYTSNPESMLKYVYECAFWTAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHG7</accession>
    <name>A0A367KHG7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KHG7"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001092">
        <property type="entry name" value="ATP-binding cassette sub-family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF129">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="1433"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="957"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1672" mass="190405" checksum="6F8776BAE4EA1E91" modified="2018-11-07" version="1">MQLGQADVFHHPLAVSDTAAGNGEAKKETEHHKGRRPSATRSVESQKQRRKSINSFESRQKNDQAVQSIQDIIGDIKRIPPVSLSDDHFWKRGRRHSEPHGRHMLSKKADTLHSIEEAKEKDENEHIELVSPSEEHMTRRNRSKSVPNTLPPIEESHRKAIYPSYLDLSEALAAIRQRKLFAGVLQIDAQDSSDANVECDELDASIYIYGSRNRNRALHGDEVAVELVNVEDMMNEKYAKMQARKFRQIPSDDDLPCSFETNETKVYPKYCGRVVCILERPKNMIFSGTLSLYRPLSAYKKPTTTEKPHASPKIIWFIPINKRLPLVAVPIKFAPAEFIKYHEEYKNRIFVGSIQRWPASSLHPFGKIVKEVGWIGELGVQSGVLMADHHIKDTSFSDTVLRAATTVPKKVTPSDRKGRRDFQKENIRIFTIGSSERDAEVAFSVSVPEKATFEIGIHVTDVAHYVREKTTLDKVARERSYAIELVEQTIPILPSNFLESHCYLLPNRERLAFSILCRFTENGTLLHAWVGRSIVRSKGHIKHVDTGGEKSEIESDASILLNLCRKLQRNRMEHEHGLSLAKHYVAFKLGKSGYPEEITRMDEADEDVLMNELLIIANIEVGQKISSRFPDQALLYRQEQPKMSAFSMIQSYLNSQCDSVHDLMNYVNEEKDHKKQQALNYVISKCLPKSKFFSAGSVDIAKYKHFMYGAPLYALSTEPTRNYASIITQRQLMIVLKGGQQETDNFDAIDKVARHCNATLAAKHSAERESKRLYTAAFIYRQSLKDMRNKNVEAECLVVGFQVPDIMFLYFPTYDLELPVACNEKSMPGHASNKGVYDADKQKMTLTWHFDKDDIQTKLCELHIMVSKLFTQNLNKFNIHLDDDAAEYISGMLESMSMDEADEIRASTESFLIDANIDEDTRSAFYSDLFENNVSTPKEIKDQKKLPKPLQGIEKAKEDLPSAPNSAATKPPKNTTRRTGRHEKLKDQDANEREPEIVAISQQSRFHTETIENLNKELDLKGVDISINQKDLLVDAHLKLKPFTRYGLVGQNGVGKSILLKCLAENILIGVPQNLNILHISQLDEFDESRMVLQEILEADKKASATIREFKALQSVMGNEKNFKASDDLNQVVYSIMQSRLCEKLEQASKIATKRSGLRGREARKVLIECEKELEEFNKKNPQTYITSGMVTEIINEVYEKIELIDQDERQHRAVKLLKGLGFSEERINAPISHLSGGWRMRVALAKSLFLRPDILLLDEPTNHLDLPAILWLQEYIINETGDMTVVVVSHDREFLNSVTEETIILRDKTLKYHAGNFEDWERNTEEQRIRKQALYDSTEKKRAAIQASIQHNMRQAKATGDDKRHGMIQSRKKKLERLGMEKTEDGRRFKLNRDRVGYHNSSRAEVVVEKAVKTATIKIPPPTELRYHGPMLTMKEAAFRYEESTNYAIKKFSISIEPNARIAFIGPNGCGKTTLLNILVGKLQPTSGEVYKHPLLRIGYFSQNVVDQLDLDVSPVEYMMSQYPSLSEQECRSHFGTSGLSGNVVLQKIRSLSGGQRSRVALALILYEQPHVLVLDEITNHLDMGTVDMLLDALRKYTGAIVLVSHDIWFLKQIFEQELDSDNDSGKEFDDEDEAAVQKEIYTIKNGNVKRWDEGIDAYVASVLKTVRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHK0</accession>
    <name>A0A367KHK0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAP microtubule affinity-regulating kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MARK1</name>
        <name evidence="9" type="ORF">CU097_015910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHK0"/>
    <dbReference type="STRING" id="86630.A0A367KHK0"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="792" mass="89883" checksum="1EF76626B652533F" modified="2018-11-07" version="1">MVLGVSNPFRSKWKQKSTTIEMKDESSTTDSKKTSAKKSKDKIAPFNSDSLLNGIGDYIFQSPLGDGKFSKVILAKHYLSGELVAIKMINKRAHEYRVMSRLVREISLMEILDHENIVHLKETIETADALYLVMEYVKGHNLEEYLKSLNKSYLPEHEARLIFRQLVKAVDHCHSKWVVHRDLKAPNILLTPEHQVKLADFGLGNRFGLHRLNTICGSMLYYSPEIISARAYVGPEVDCWCLGIILFRMTAGYEPFAHAKTVSELKKYVIGRHYKIPTHLSPSLQDTIQKCLSVEKYERLCLRSCLSGDPWLNNYGELEDVFSERIQSPFYHAIEATEAYAASGRADDKAKLQIASKNTKMVCKRDLEEEKRRGNKVPKTIIYHITNPSTYFTGQAPHSSKMPIDLDAQSVVRSELHQNIMVSLKQIKLQSIHQFTELKSPISHLFRKFKRADIVIDQHTEPKQIRKAASALSLSQIYQRVAKDHISYYTLQCKVRSGSSTTVVSGYSTTSSTLTAVERRPRRLSHRVSVTFNAQQQPQAQSKDEEYEQSQEEMIKMIRLVCELLGITYYQNSSHQLVCLLTLRNFKKPAQYATTPNGSSLFRSKLFNSNDKLSEMHRQHQKATTSSFASVNSANPSSIQHIHPGWWTRQVQRLSSNHSLLTSSSAAVGMMLNKKRSSHDLLSMGRMTQEQQMKLQSSNSEEDNNDGYVILTIDALSVNHQSHDEGQIVAVRYSKVKGSTKVFKLAKGWIQMILKSPSTDMRSVTAKSSYDCVSQHAQYTTATSNTTTTSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KIH9</accession>
    <name>A0A367KIH9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000001">
        <property type="protein sequence ID" value="RCI01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KIH9"/>
    <dbReference type="STRING" id="86630.A0A367KIH9"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="351" mass="40159" checksum="25C8164F7D74B958" modified="2018-11-07" version="1">MPLESKSTQKMSYVPFGKTGMKVSRFCLGCMSFGSSRWKVWAKDERESLELIEKAYKAGINFFDTADMYSNGESERLLGKAIKKFDIPRSQIVIATKVFFNVFDDVSRQCSWDRRNECTFEYINTLGTSRKHLFDAVDASLERLGVGYIDLYQIHRFDPQTSIEETMEALHDLVRSGKVRYIGASSGYAWQFQKANAIAERNGWTKFVSMQNFYNLLYREEEREMIPYCQDSGIAIIPWSPLAKGYLAGRNRKTARTSSDMSIPFLFQTEEDSNNNAIINRVIKTAAKYKCSPAQVALAWLLSKPYVTAPIVGITDGSQIDDMIGSLEIRLSKEDIKYLEEIYEPHRVRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJ47</accession>
    <name>A0A367IJ47_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005741">
        <property type="protein sequence ID" value="RCH77690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJ47"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="81" mass="8695" checksum="198F40131B9B7B03" modified="2018-11-07" version="1" fragment="single">MNVVLSLAGMTYRFPVKASTFKSASQLKTVCCSGIRKYAVCKGCHGLYPSGVSMAPIPDLCNMDDCRTPLLLPSRTIPAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK11</accession>
    <name>A0A367IK11_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005491">
        <property type="protein sequence ID" value="RCH77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK11"/>
    <dbReference type="STRING" id="86630.A0A367IK11"/>
    <dbReference type="OrthoDB" id="5426307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016827750" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="13275" checksum="449D9AA3C80E6285" modified="2018-11-07" version="1" fragment="single">MRFSLALVSSALLAQLALAAPASQSNMAIAEGDFKSAQVTPLKVQENFSVFHWKKEDGEDATIDRVFSFELNEPAQLQITDYLKSGDVYEISDNGEVIGATTKVDSSEEAYAITPEQALTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL37</accession>
    <name>A0A367IL37_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005200">
        <property type="protein sequence ID" value="RCH78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL37"/>
    <dbReference type="OrthoDB" id="2238225at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17411" checksum="DEA04EE6B7249211" modified="2018-11-07" version="1" fragment="single">MTTFYKINNLDLTSSNQLLAIDNSIVKDVRRFVGCLVKANNFSLLVNSFDLICHCQPDQDDFANGLDVEEIATLPVCKLRHKTSTNKSYKEVSIFIELYELLVVGGYILLNDDLTPFLGSSLGNIGVDYDESSQIYIPTSQQPFINTRRLMTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR26</accession>
    <name>A0A367IR26_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004102">
        <property type="protein sequence ID" value="RCH80096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR26"/>
    <dbReference type="STRING" id="86630.A0A367IR26"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH80096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="351" mass="40270" checksum="965E457FD392AAD7" modified="2018-11-07" version="1" fragment="single">MSDMRNVNNWHWVSKDCRSWAKKYLTEQLVDLSTKNGNVNVRITSLDECNGDVDLNQRKGKLFAIYDLVLKFSWEANQDGKRAFGTISVPEFAYDTDECVFKCTVNQSSEFDLKAKQVVQSLLIPLMKEKLAKFTRDLVDSYSADLYANSSNKKEHTQNKSNVSLQPIRSREDTDTVVKTTVVNHSFEFKGGDAKQIYEALLDPKRAVIWTRTSKSLRLSKQIGSTFELFDGNVQGVLLDLVPNKQIRQTWRLKSWPKGHFSTVTINLLNSQEGVTIHVNQTGVPAAEEESIKRNWMGYYWQSIQAYYPQLSSMHIEREHSFVRYQYYALIACFIVLALSIAISFSTTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT70</accession>
    <name>A0A367IT70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003793">
        <property type="protein sequence ID" value="RCH80671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT70"/>
    <dbReference type="STRING" id="86630.A0A367IT70"/>
    <dbReference type="OrthoDB" id="2221396at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="15684" checksum="6027081C5727B16B" modified="2018-11-07" version="1">MTNAISKSQQNEIRSLLSQNKSYSEIMERIPGLKKPTLSRYANKFYPNRVHAPSGRKSIVTTTTKSYIRRQIIKGDLKTAKAVYQYLNEVGYSIGYSATLKLLKSMNFQAKIKVKKPLLKKNHRERRLAWAIAHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV49</accession>
    <name>A0A367IV49_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ASN1_2</name>
        <name evidence="14" type="ORF">CU097_000432</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01003372">
        <property type="protein sequence ID" value="RCH81585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV49"/>
    <dbReference type="STRING" id="86630.A0A367IV49"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="13">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="12">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH81585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="444" mass="50098" checksum="D3128CA2AB11743C" modified="2018-11-07" version="1" fragment="single">MCGIFAVYNYQGDAEAYRQRALYLSKKIRHRGPDWSGCVIANNHIFSHERLAIVGLSSGAQPIVSEDGNLILCVNGEIYNHKQLRNQLKEDYDFKTESDCEVIMHGYKELDKDIVQHLDGMFSFVLLDKARNRVIAARDPIGITTLYYGWNSKMPGTVYFASELKSLNEDCDKILAFPPGHIYDSDTQETTRWFNPSWWDGDRVPTNPVDYTLLREALEKAVRKRLMAEVPYGVLLSGGLDSSLIASIAARETEKIAAGYRGSDSDIENFDESGPRLWPRLHSFSIGLPGSPDLIAAREVAKHLKTVHHEYTFTIQEALDAVSDVIYHLETYDVTTIRASTPMYLLSRKIKALGVKMVLSGEGADEVFGGYLYFNNAPDKESFHAETVTRVKNLHTADCLRANKSTMAWGVEARVPFLDKQFLEISMNIDPAEKLHDRSKGRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW18</accession>
    <name>A0A367IW18_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NMT1_2</name>
        <name evidence="13" type="ORF">CU097_004034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003267">
        <property type="protein sequence ID" value="RCH81816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW18"/>
    <dbReference type="STRING" id="86630.A0A367IW18"/>
    <dbReference type="OrthoDB" id="434407at2759"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH81816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="38985" checksum="DA6B4EE3392B7C69" modified="2018-11-07" version="1">MVTTEKITCLLNWKATPYHLPLFLAQQLGYFADEGIKVAILEPSDPSDVTEIIGSGKVDLGLKAMIHTMAGKARGYDIKSIGTLLDEPFTGVIHLSHKSGITNDFQSLRGKRIGYVGEFGKIQLDELTRHFGMTPQDYQAIRVGMNVTDAIIRGDIDAGIGIENVQQVELEEWSVQQGRSRDDVQMLRIDELAELGCCCFCSILYIGNEEFIKNNPEKVRKYLRAIKRATDYMIENPADAYSKYVKIKPHLDTDLHRKIFQRSFRYFSRDLKNVQRDWNKVTAYCKRLSIVDADFEQNQTNEFLTWPLLPESQPGVEPTTVETGVVEGGCTRCLHSSIAPPKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW19</accession>
    <name>A0A367IW19_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003246">
        <property type="protein sequence ID" value="RCH81867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW19"/>
    <dbReference type="OrthoDB" id="2286042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="10116" checksum="A423BA7D2ABD1FCC" modified="2018-11-07" version="1">MKDVFAITNQYTDIMMDKTDQSFATWRTIDVECAIYKKKEYLDGLVKGIRFIPDHLTHIKGLNEQKISIVDYARESPDNGEEQQITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWL8</accession>
    <name>A0A367IWL8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myb-like, SWIRM and MPN domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MYSM1_1</name>
        <name evidence="9" type="ORF">CU097_000341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003182">
        <property type="protein sequence ID" value="RCH82016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWL8"/>
    <dbReference type="STRING" id="86630.A0A367IWL8"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="6">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH82016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="424" mass="48838" checksum="4919A1917B30E5BC" modified="2018-11-07" version="1" fragment="single">MHEEEEEIIDIGEDEKQELIDSSGNSNGSSQPTMMIEDQDMDKDSRQLIEQMLAEEEYYFFNKTTKNYDSDYPKKTKDISSAALPSHKTRWNKEEDDRLKEALDIFGYGNWKPIAEHVGTRNRLQCKNHARHLLLTPSKQKREESKEISKQTNTESETEMITADDADNTSDTTLPVNTTNTAGTTTTDVTMDTATVNEDGDDDLDIGDPREIDIPDNDTHVSISHFDRHFVSEEEKKQNPEWFQNKHAKTPDRYLRIRNHMLDCWNQCKPRYLTKTSARKGLKDCGDVNAIGRVHSYLESVGAINVDCITNAPRPPKRVPREVIVEEDTLDAADLVINYDGPRKRKVRNERGEWVDPRELEGRVIEHGVQVETDSNGTKSKRVKRSFHQHYYGGDDFNRGYDPFRLVPTSHYNELFPAPFEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX03</accession>
    <name>A0A367IX03_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003134">
        <property type="protein sequence ID" value="RCH82139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX03"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="59" mass="6734" checksum="62217D7D31DAF7FA" modified="2018-11-07" version="1" fragment="single">LSMYKGNWKTLSSVSFEADKGYPNGKSRGRLFTQIGQVEYSSPILPPDRSFHKKVKQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXU5</accession>
    <name>A0A367IXU5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-protein scj1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SCJ1_2</name>
        <name evidence="4" type="ORF">CU097_004254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002984">
        <property type="protein sequence ID" value="RCH82525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXU5"/>
    <dbReference type="STRING" id="86630.A0A367IXU5"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="16615" checksum="0E1814E7016B7463" modified="2018-11-07" version="1">MGINDKSPYEILGVGRYSTQKEIRKRYLELCKIYHPDVSKIKDTTARFKDIKYAYEVLTHKTIPKQPLIRHYPPSTATTTIDTHLWTRRSILGGFGLMAVVIFYLSMDRQEESYSKIESVATHKSPTPWKEAGMSFRDWRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYJ0</accession>
    <name>A0A367IYJ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YmL10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRPL10_1</name>
        <name evidence="4" type="ORF">CU097_006961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002906">
        <property type="protein sequence ID" value="RCH82755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYJ0"/>
    <dbReference type="STRING" id="86630.A0A367IYJ0"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="206" mass="23258" checksum="7EC0AB7A8F9BD74C" modified="2018-11-07" version="1">MSLRSFSHSLVSNLKPINNTIIRSYATQKRVPVHPPRRTFLYNKYSDIIQNNRAVFIFQHNNLNVKEFTQIRQGLSQIQGGSETTLTVLRPSIFAAALRETRYLNLEPLLTGPTCVFYTNVSDNEHPELLKKSVEMLSKNKKMLLLGGKLDDNLLTQGDVLKVVELPPLDQLRAQLVGVVEAPARKLISTLSQPSSELHSVLSRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ20</accession>
    <name>A0A367IZ20_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="8">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TARBP1_2</name>
        <name evidence="12" type="ORF">CU097_001984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01002842">
        <property type="protein sequence ID" value="RCH82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ20"/>
    <dbReference type="STRING" id="86630.A0A367IZ20"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="11">
        <location>
            <begin position="302"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="461" mass="53585" checksum="24AF0F1B27FD8D73" modified="2018-11-07" version="1">MYTNTVEHRLKLRVCCSTILIIDLVSEDKVDACLETLFEITRKETVTSVRCYLEWSIVRLLCRFPDRLPLYYQRLSDTSHKPNYVISLLTLSFTLGQCLPESCVERYFDEIFVRLLPWLITNHFTIRLFAYCGWQHNWKACIKRGHGAMLENNRYLDSIGNFMETYVDCIKFFDKIQAQFYMARFDPIQDFNVEFIFRQMMTEFQVIDNEKIGSKAFVRVNPQRVERCPFENPERRSVYTAADPSELIGTEQPDAMVMIDTPSNQSSEDVYQKKIMPWEMMLETDMDLTKNLVKKNRRRNDLIVVASLIDRLPNLAGLCRTCEIFNASLLVVPTLKIKEDIGFTSVSVASERWMPMTEVPESEVAKFLKEKREEGYTICGLEQTTTSATLGEYMFPEKCVLLLGKEKQGVPADLLQMLDVTIEIPQYGITRSLNVHVSGAICIYEYTKQMQWRQQAAINQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZK6</accession>
    <name>A0A367IZK6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PFDN1_1</name>
        <name evidence="4" type="synonym">PFDN1_2</name>
        <name evidence="3" type="ORF">CU097_003457</name>
        <name evidence="4" type="ORF">CU097_005051</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002770">
        <property type="protein sequence ID" value="RCH83112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000784">
        <property type="protein sequence ID" value="RCH92747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZK6"/>
    <dbReference type="STRING" id="86630.A0A367IZK6"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="14039" checksum="D08BCDD68A806E73" modified="2018-11-07" version="1">MATLSDDAIRKVFVELQAKYIQSQQQVATVKAQIQAKQRERKMAELTRRELDSLDPNTKTYKPVGKMFIQSPLSDMKKQYVDSIAATDETIKQLEKTQKYWERSVSDAEGNLKDILQGPRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2I2</accession>
    <name>A0A367J2I2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002446">
        <property type="protein sequence ID" value="RCH84154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2I2"/>
    <dbReference type="OrthoDB" id="2255999at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="189" mass="20677" checksum="EB1226A4BF9F3C32" modified="2018-11-07" version="1">MKISRHTSSRLHKKPAYTSSYDHTSISLISPSVTPQACCSFSPTYSSVTTATIDASDIFHIPSVTAVASQFDPGIGQSSLTRADFPVTTTPIQMVILIVGLIGGTAFIAAAMFLVVRKRRTAFGDNKKDSSDEGDEEQRMMAYLPELALTKQTNNEYQQMYNNNEPEKDNNNENKANNSSNSAAELSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5T5</accession>
    <name>A0A367J5T5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002188">
        <property type="protein sequence ID" value="RCH85081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5T5"/>
    <dbReference type="STRING" id="86630.A0A367J5T5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="326" mass="37513" checksum="9494DC99A81B6174" modified="2018-11-07" version="1">MFNTSNNTNNSSNNGGITSFLKLKWRTSTKYNIKPRLPNTVDDIERDWVRHNALKLAFENDFKAPIERLLQAGGSEVLDIGCGAGFWTTDMAARFPLSYFIGLDIDKNVLPTSPCGRNVLYQHMDLIELPLPFEDATFDYVFVRSMLSTMPDHLWDDVLKELIRIMKKGAYIECVEAYDNLFDTGPSMNILIELVLRSTQQPPYSPTKENSRNPWPNRLANISQLMGMRIHHTHTPVGFHGGEIGALLLEYWERMISSYRDEWIANKWIDEEELEKTIELMKEEVEEHNTYMSWYSVVARKKGYAGPVLQFDDVDDDGTVYTTTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J657</accession>
    <name>A0A367J657_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002103">
        <property type="protein sequence ID" value="RCH85418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J657"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="16589" checksum="406E0D755EE1FD3D" modified="2018-11-07" version="1">MRFSSLSAELDAITKEFDYGIVPGSATVFVRDEVNNIGRLDLTLLEGVMIVIEVTDQGYRVTSCSPLCNVDPALSTAQNVQAHLEHNFETMENLLMTISPMFRERFQQALYDKLQSVQSQQLEPSSGKQQQQNDTMTAPHSFDEWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6F5</accession>
    <name>A0A367J6F5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Man1/Src1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002085">
        <property type="protein sequence ID" value="RCH85490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6F5"/>
    <dbReference type="STRING" id="86630.A0A367J6F5"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH85490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="715" mass="81771" checksum="7A775C162A758160" modified="2018-11-07" version="1">MSSQRTIPEELYYLRPNHDLRRFRKAELKDILMKHGVQYGPLMTRTELLHLFKNKVLSRRNDIIDTYYTTIDNRNPIDADGFVMPISSPIRKPIYPYGAEDSFAESEDDAPVHEPSSSSRATQFISDSVNQWFSSKQQDRPEKNSANETESNTAHFDPYDSFVSDNDELAIVPTTQLSYSGTTNDNNKPNVENEPDVKQADACKSSPKPEQATSIENNPDAKPVTIDDGEQDVTDEDRNSDASYEVYTQSSGSSQSPYASEDSNDQSSGDEDDGFDSDYYPDDESDDESDNDSDELRKGIDEKELVYLRSDSSLPPESLRQLYEQRQAHSERLTVRKMIMVIVNTCISYFPFNARDHFLPFRFLFTTLALSLTLFLMIITLFRYKNGYCSNHKAQDYQSLYYSHFPSTCIPCPQNGICVSGKLTCESIYVRQRPLYNPGGLLPIADKCVHTADMIKQINKVVKHMKQTLTTAQGNLIYNEYKRNPRHQELPQNIAAFYQSDFLDEMKTYVNSDELTTTEVYGILNLALKKLSGHSTIYVWENKNGVPMIGTTSAAFPFRYYLLRISCKLFYGDTRYIILSIILTAVAIPVVAAGKVYIKRRRAYKDKINRYLSDILVWLRDPHEFYVQRPTRAYQTLKNSGVIPVDTLRAELMHINEGCSAKDWAQVVNIVHKNPNVLRTICEVQGHLVECWGLTPVSYIPQKPSILQTIVNRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J718</accession>
    <name>A0A367J718_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002074">
        <property type="protein sequence ID" value="RCH85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J718"/>
    <dbReference type="OrthoDB" id="2219672at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="134" mass="15305" checksum="4C31943E8AD8252A" modified="2018-11-07" version="1">MAIYTSGQYLYCICSEIIANSEAISDDDMDHYLEDNKQEEIEIDHFNLSECVREYMDVDPPEEDEDSFGDAVLFAGSMLKKRHMALNVKKRDFYRRYTPKQAEKLFDLIIEKGFTAKAAALNTGINVGPCSKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J771</accession>
    <name>A0A367J771_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_005531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002017">
        <property type="protein sequence ID" value="RCH85778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J771"/>
    <dbReference type="STRING" id="86630.A0A367J771"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="149"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH85778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="33100" checksum="152D7B50EC0E44EF" modified="2018-11-07" version="1">MSEETFDKRKNYATEDRRRSLNSESDEEELDEFGRVKRRREKFKSERAEEKEYDDRSDSDRDMHRRDDRYHSKRRRRRSSSSSLSPRRSYHRRYSDDSDSDYDRRHIRHSRSNYRSSSHYHSHPRHYHSSNRDPYSEAAQYLDTEFYSNKIYVGELENITADQLRDAFSRFGTLEDVRMAEGKNYAFITFEKKEAALAAIKNMHGVLFGAKQIKVNRAKIPERNKVGFGNVPWQDEDGLMAKEAMYTDDRSRPVSKPIDDTQPLEPIPQRALTTYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J867</accession>
    <name>A0A367J867_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001981">
        <property type="protein sequence ID" value="RCH85931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J867"/>
    <dbReference type="OrthoDB" id="2257833at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="11035" checksum="11314E986D66E278" modified="2018-11-07" version="1">MTLYVLIDELDQLKKEAYKELQSQIDSYSNNFISHMRRIEKGHQEKDDDQVQELVELFRTGGSIKDYSTLVEWELCKQPTTYFDNHGECGDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8I9</accession>
    <name>A0A367J8I9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001908">
        <property type="protein sequence ID" value="RCH86253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8I9"/>
    <dbReference type="STRING" id="86630.A0A367J8I9"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7889" checksum="43ED6FB40F75CBAE" modified="2018-11-07" version="1">MFRALNRFAIERPVIFWSCVLGGIGPVMVLTVPKIRREYFGFKGYEPLPITYPLPNRSRNPPSGYEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8U2</accession>
    <name>A0A367J8U2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001895">
        <property type="protein sequence ID" value="RCH86315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8U2"/>
    <dbReference type="OrthoDB" id="2298211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016977283" description="SLH domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11055" checksum="DDC84C239CD92ECC" modified="2018-11-07" version="1">MAIGLSGLATLLFGTTFPQFDPQVNQSNTDKFKTNATSFFIANEDRPAVDDNKYSSKQWRAPPKDSTRITREQAVRMLFYVKDTRILQQILDHNISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8Y6</accession>
    <name>A0A367J8Y6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein nst1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001875">
        <property type="protein sequence ID" value="RCH86403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8Y6"/>
    <dbReference type="STRING" id="86630.A0A367J8Y6"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="57724" checksum="2BAE13725733A532" modified="2018-11-07" version="1">MEEERQRREKERLRKEEEKRQREEERQKKEEEKKRRLKEEKEREKKRREKEEKERKEKEERERKEKEEKERKEKEERERKEKEEKERKAKEEKERKEKEEHERKEKEQQEQRKANKEKERKEKLRLENEKVDEQEKPKEEAMVVTPTATTAPKQPIIEKQPVLPQYSHIPPDDFENRQQVLIEALVGSTSRPSNFQQPFMPLSRHLGGTPASFLSTSLDHTSPLSDANSSVLGLFNNRSTAPPSTSLLTETPSTRRSLTSIAPIGQPIHNGRRSSVQPVGTIGSLPDDAFLSGKRTETEGTTARSFFSSFLFGEPTKYHNNTSPPLVMSHDYDTRLAQDNRRFSGDGQQQQHTPGWTNAWTASSLLTDNVHGKLFGDALPDRTAMTLERVKVAYQKLNEITQVKMFTGYHTLVQLHRMMNDLYIDFPIDIRELYEILCSPLSGFRCFHHGQHGIVVLYDNSSMASTTNFSSPPHSSLLLPSHPPPSLQPGNNPPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J916</accession>
    <name>A0A367J916_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001866">
        <property type="protein sequence ID" value="RCH86442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J916"/>
    <dbReference type="STRING" id="86630.A0A367J916"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="42"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH86442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="541" mass="58462" checksum="5C6CC695E8758906" modified="2018-11-07" version="1">MDNEKVQVVSETTTIEHVDTYKSEQSTTEKRHSLKRGLKARHIQMIALGGTIGTGLFMASGKAIVNGGPGGAIVAYGLVGILVYCVMMSLGEMAALIPVAGSFSHFATRFVDPSLGFCVGWIYWANWAVGVAVELTGVAMIMEYWVKSVNSVIWSVICLAILVAINVFSVKGYGEVEYWMSFIKILVVVIFIIVGLCVDTGAIGGVNIGVSNFHLPGGAFPHGFLGVFNVFITAAFSFNGVEIAGITAGESANPHKTVPAAVKQVFIRIVLFYVLSILVIGLVIPYTNTQLLNGSKDISVSPFTLVFEKAGAAWAADLMNAIILITMVSAGNSGVYSSSRTLLSLAEDGYAPRFFTRVNRFGIPIWSVLATCSIGCLAFLTSLFGSGVVFNWLTCLTSLAGLITWVSICITHIRFRLGYLAQGRSLTALPYVAPLFPICDIIVIVIGTIIIFGQGYATFIAPIQASNVISSYIGLILAVVLYVGHKLWKRPGFVKYVDMDFETGTIQDTVLDIRKDEGLDENGNPLPLWRRIWNKFIDIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9B1</accession>
    <name>A0A367J9B1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001845">
        <property type="protein sequence ID" value="RCH86544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9B1"/>
    <dbReference type="STRING" id="86630.A0A367J9B1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="47531" checksum="A1F4B28EE62A2518" modified="2018-11-07" version="1">MRIFWHSGKEGEPLSLLYQTLSTPTRSLNFPAEIVKRIVDYLPRSSLPAAAGVSHLWYTVVMPVLYRHLYIRTFPHWMLLQRTFEDIEFAKQFGPYVSSLVLKPSPRLISSQLTSVLNVRAIENNDELQPSTRGYVRLERVNYDLTGLEHIDTPWSVDKQEDNENYRGIDTSSKEAEWLLSVTDDQVCNVLNYCYNLEYLDLSGCERLGDKALFPIFYQKKAHKNKRPARLKGLWLNLLRKLTIESLANFVYTDISLEGPNQLRHLDLEFVVDLKDMHLDLILSNLGSSLTHLRLNSAYSLTNAAIETIVKHCPNLKLLYLTRCWRIDNRGLELLVHCTKLQYLSAAFLSSTNETSLGQLVKNNRELVWIDITGCGINSVFKEMILESWKMYRIEHRLPPLFIQDGKLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9F2</accession>
    <name>A0A367J9F2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_000342</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001844">
        <property type="protein sequence ID" value="RCH86546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9F2"/>
    <dbReference type="STRING" id="86630.A0A367J9F2"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="14">
        <location>
            <begin position="293"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="397"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="13">
        <location>
            <begin position="398"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH86546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="530" mass="59344" checksum="B50D0925617B5AF1" modified="2018-11-07" version="1" fragment="single">MLDLFTIITKGGFVLWQKTFAPISGFPVQELIKNVLIEERSGTTEYIQNNYALRWTFANEAELIFVVVYQKILTLNYLEELLETVKRVFLATFQDILQKDSNSDFTSFGPIFDKLLKQVEEKYANLRQKAPRKFENTKKFESTLKASQAQNTGALPVSTAANTQVDEDEIAKNIRALKIQGNSPRTKGAKKPAKTANKQQIPEDTQKKKKSQKQARVWDGQISKGEMESLDYSSKSNGVDEAPETVASQWVDESKLGKKNEKGIYEVQDIMQQENDEDEDEDEELDFDQPVDLQKKSGGLFSYLKSFTGSKELTAEALDPVIATIREHLVAQNVATEIADHLCQSVKSSLLGKKLGSFERVSTAVRNSMEAALKRILTPKTSLDILRDIEQAKLDKRPYSICFIGVNGVGKSTNLSKVCFWLLQNNYKILIAACDTFRSGAVEQLRVHVRNLRALQTSGEGQVELFERGYGKDSAGIAKDAISYATANHFDVVLIDTAGRMQDNEPLMRALSKLVSVNQPDKIIFVGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAX9</accession>
    <name>A0A367JAX9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001728">
        <property type="protein sequence ID" value="RCH87104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAX9"/>
    <dbReference type="OrthoDB" id="3363059at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="373" mass="42874" checksum="E4A17F0A6603269B" modified="2018-11-07" version="1">MNTEPVNRYLEFRKTSTKIGLEEALVQFKTVGQPNWKFELLCELFFIVNQVQNETTERTNVAIRSFIKLLNSEPFISEHSKSIVETVELFQDIEYQETSIGVTRYLVEGLVYLPTRAILIKTLSKSSDVSKENTVHYALSCAYRLNSKFMLQLSEMMNALVEANPEYAWSIRLELVEMKILPDVITRITAVYCQDEINFFNSIFQQVASWFLAQSAASRQYFLTMKNRIISEIEVSYSNGDYARVASAIRALAGIAGYFGVKLNDQEVDVFINLLNQTESERLVQLILCLVLITADQFLKRQKNLSEALCRLLQCNISEMPLLILVYFETDAIFQVEDTVRSTIAMQVPIPRFGLFEIQKLFRSLKNSVLPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB72</accession>
    <name>A0A367JB72_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZWF1_2</name>
        <name evidence="12" type="ORF">CU097_009452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 9"/>
    <dbReference type="EMBL" id="PJQL01001712">
        <property type="protein sequence ID" value="RCH87178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB72"/>
    <dbReference type="STRING" id="86630.A0A367JB72"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000018">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="208"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH87178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="508" mass="58387" checksum="AB01FC34D6BB08C2" modified="2018-11-07" version="1">MPQETAIKKLRNDVANRLKGGITIVVLGASGDLAKKKTFPALFSLYKDGFLPEKTEIVGYARSDLDTQEYHKRVTANLEAEDDESKKKVDEFIKLCHYVKGKYDEDDSFKNLDKYISESEDKRGLKGDQKNRMFYMALPPSVYVQVSQGLHKFVRSKEGHNALVIEKPFGKDSESACKLLNEIKKLFPEEEVYRIDHYLGKELAKNIMNVRFANMIFGPLWSSQYIDTVQITLKEPFGCEGRGGYFDEYGVIRDVLQNHLLQLFALVAMERPIKREPEAIRDEKVKLLRCVRPVKMEDCLLGQYVKNGDKPGYTEDETVADDSLTATFAALVLWIDNERWDGVPFILKNGKAMDNSKAEIRIQFKKVPGNLFHGVPRNELVFRVQPGEAIYMKFNNKVPGFSVDSMITELDLTYKSRYDNLKIPAAYETLILDVMRGDHSNFVRDDELVAAWNIFSPLLHQIENDKVKPHPYPYGSRGPEPLDEFVKKYGVERIDHENYQWPKQNLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBB9</accession>
    <name>A0A367JBB9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001696">
        <property type="protein sequence ID" value="RCH87252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBB9"/>
    <dbReference type="STRING" id="86630.A0A367JBB9"/>
    <dbReference type="OrthoDB" id="2538345at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689:SF1">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="230" mass="27089" checksum="7FAF38D0096BF2D6" modified="2018-11-07" version="1">MATSRSSRVHSRHSSSKRRRSESPIKYKKKKKSDNSSSSSSSRESSPDKRHKRHKKHKKSKKSKKKSKSLSIGDQWGKYGIIYESDIFTKEPEFQAWLIEVKDADVETLSQSKRKEMFIEFMEDYNTATLPHKKFYSIEKWEKRQQAIRMGEQYVEETFDFAKDEERLRQHHKQAAKAAAASRQPALQLSEDQIKELSRVNRERIEADRMRKMGLTPKEGMGVRYEEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBK2</accession>
    <name>A0A367JBK2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001693">
        <property type="protein sequence ID" value="RCH87265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBK2"/>
    <dbReference type="STRING" id="86630.A0A367JBK2"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="32380" checksum="0901981AB64E57CC" modified="2018-11-07" version="1" fragment="single">VRLYEVQPTGNTVPKASYNHEGPVLCVDWSKDGTAVVSGGTDKAARMYNIVTGQSTQVAAHDEPIKAVKFLDGQANILATGSWDKTIKYWDTRSPTPVGTVQLPERLYSMDTKNGLLVAATADRHVLVFNLSNPTTIYKKTISPLKWQSRAVSCFIDGKGYAIGSIEGRLGIQYIDEAESAKNFSFKCHRDETKNVYSVNSIAFHPVSGTFATTGADGTVTFWDKDSKQRLSSLPRQNNTIACGAYNRNGTIFAYGISYDWTKGYKLYPTEGLVNRIMLHAMKDDEWKPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBZ5</accession>
    <name>A0A367JBZ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001671">
        <property type="protein sequence ID" value="RCH87379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBZ5"/>
    <dbReference type="OrthoDB" id="2251127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="257" mass="28793" checksum="FA2B52262AF6EBB9" modified="2018-11-07" version="1">MVAHPSVSDTKAINQREHTPGEKKESKKTERRYHHRDQIRLPLVTRKSGNANDSSSGSSGSNHQHLIVDTVVSENDKQEAVISQNPLPIHIETVLRSFSNKDARDSESDKASSPSIVVSPISLFSNHSQLEQEDFPLFSDHDSGADSNLGSPFMPEHELPKKINYYSPFVTGFDFDIAPAYDTIESKAMSNFPSKIDHDLVSQMAGWKDKAPLSEAFSVSTEEVDMVHETSILNFMNQVDTEYTAFLSKHLEVKYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD05</accession>
    <name>A0A367JD05_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001589">
        <property type="protein sequence ID" value="RCH87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD05"/>
    <dbReference type="STRING" id="86630.A0A367JD05"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="356" mass="40519" checksum="133EBF5B30375773" modified="2018-11-07" version="1">MSLITHFVNHRALVTGSLILLGGLSIYYLSSKGKEFNDRDVSSADENQSQQEKTEKSEEANEEKQESAVADRSVEPIEEKTSKITAADIKKESVTIVEKGTVTEPEQVSVISTEEAVIIKDEPTTTTTIVETTEKTQMDDSIVAHVQEEFVIVDKETMTTVEDEPVKSTDKESTKEEATRIKTEEEVTSLSIAEVPTATITEPAADTQYAASSADENDIGTPENEPVASIPTFRSFDDIPEFIPQQKQQPTRKRSKKSLTRIQLIEQQRQNHTPTVNARCNHWPRCTNKHCKYWHPFKMCRAGDSCYYGKKCMFVHPSDYLEQPERKNSYPAQQQQQQRDQQEQQQQPHQQQQQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD50</accession>
    <name>A0A367JD50_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-specific adenosine deaminase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ADAT1</name>
        <name evidence="2" type="ORF">CU097_009799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001577">
        <property type="protein sequence ID" value="RCH87863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD50"/>
    <dbReference type="STRING" id="86630.A0A367JD50"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="404" mass="46266" checksum="73858846E2D19860" modified="2018-11-07" version="1">MSWKHDPDAIVNATLKKYKELPKQGKPIFHETKAEWTVLASIVMVHDLSIDRGHFIRYSTGLKCLPFSKLSKAGDTLHDSHAEVIARRGFIKFLLEYAKSFDPSHQDSPFYKKDGKLALRPEYSFHMYISQSPCGDASMTALAAQQTSESFEQFQSGSNKRKRMVEYLTENMYINKKQKISTQQFRRGRFEYDQLGVLRTKPGRVDSEPTLCMSCSDKLARWNVLGIQSALLTFLFHPIYLSSVTIGDMYDHEAIKRALCQRLSSLEGLPSSYRLNCPIIAKTDIPFEASKSVLEKRYASTIPSSTSILWVKGMAKSEVFVNGQKQGAPKGKPTTAKTRPSICKLNMFHEFLTIRQKEEKEEKEGQNYSEWKQGAIEYQKAKTCLLDQVFQSWVQTPLEYEQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDV9</accession>
    <name>A0A367JDV9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionyl-tRNA formyltransferase, mitochondrial</fullName>
            <ecNumber evidence="2">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001537">
        <property type="protein sequence ID" value="RCH88059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDV9"/>
    <dbReference type="STRING" id="86630.A0A367JDV9"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="7">
        <location>
            <begin position="237"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="383" mass="43585" checksum="3DF15039EB4FC10D" modified="2018-11-07" version="1">MLLLKTNRLFGQFVLSRHYSTSNKLKLLFFGTDDFASLHLKALIKEKKNENSCIESLELVCPPDRFTGRKLETLTPSETKGVAELYNIPVHHTPLQAKTLNDWHLPKDQQYDLGVVVSFGYFIPPHIISQFRFGAINVHPSLLPKYRGAAPIQHAIINGDHETGVTVQELDDKEFDAGRILAQERVSLSDKAPFYSTLKKTLGAVGSNLLVDTIQHIHERKASARTQDVSQATKAPKIKKEWSEIDFENMTAWKVEQLSRAIGEQYPLRTTYTKKKKRKLRTYTVQLMHLFVPAHPCPLLEGLEPGEWVWHEQSKSIHILFKDGSVIACPTVKLEGRDAIAAKDFVNGFEHEGIFGVTRLYDEVARKKTLKLLTNMKKYTKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEZ0</accession>
    <name>A0A367JEZ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PFA4_2</name>
        <name evidence="11" type="synonym">PFA4</name>
        <name evidence="15" type="ORF">CU097_008248</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01001467">
        <property type="protein sequence ID" value="RCH88439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEZ0"/>
    <dbReference type="STRING" id="86630.A0A367JEZ0"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="91"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH88439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="388" mass="44179" checksum="201A08F5125C19CD" modified="2018-11-07" version="1">MLESIPGKIFVVGVVCLICFIAYSSQLCIFIPAYETSDSILLLVPFNILVLFVFYNYYLAVTTDPGKIPTNWEPPSSLIAPVIATEGITGPRYCKTCKTYKPPRSHHCRYCKRCVLKMDHHCPWINNCVGHENYGHFFRFIICVDLACAYVIALLIGRVRAIMDAIRHFQFDAEPNTFVIVFMVANFVLAFVVLFAVGILSGYQFYCLLRNQTNVEAWERGKVETLVRRGKILPVNYPFDIGIYKNICQVLGPNPLLWLWPQRAVGDGLSFPVVSGTDPRLPYYWPPRDPDDLRPSIFSSKYKRQQEARRLLAENPDANVDDESEGYYDSGSFISDSDEYDEEVGMKNLTGFYDISATSPAHEHSDEERPLAYFARKSHGSPVEKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFJ1</accession>
    <name>A0A367JFJ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PTP4A1_5</name>
        <name evidence="12" type="ORF">CU097_008435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001425">
        <property type="protein sequence ID" value="RCH88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFJ1"/>
    <dbReference type="STRING" id="86630.A0A367JFJ1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="198" mass="22671" checksum="FF8406C62573988A" modified="2018-11-07" version="1">MVNQRTGSPLGRMLSLIEVPSVSLKFLILDCPTESTLPYYLEEFKRNQVRHIVRCCQPTYNTSLLQQEGIQVHDLPFKDGGVPPAQVVHDWLHLIDTEERKQESVTIAVHCVAGLGRAPVLVAIALIEFGMEPLDAIEYIRRKRRGAFNKPQIAYLDQYKRTLRTKSNHNFKMSFSRMFKFGKKQQEPPSSIPLSSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFJ8</accession>
    <name>A0A367JFJ8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyceraldehyde-3-phosphate dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GAP1_4</name>
        <name evidence="3" type="ORF">CU097_010183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001431">
        <property type="protein sequence ID" value="RCH88639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFJ8"/>
    <dbReference type="STRING" id="86630.A0A367JFJ8"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="188"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="797" mass="90573" checksum="86D177536195CE6D" modified="2018-11-07" version="1">MTDRKSGMVQAYGYPTTPSNQIVSRAVAAAAANSHHSGRGKSRNSKRYSVSAFYSMAAEQDNEVEDELAQAQRSLRELKSKISAQSKKNFVLERDVRYLDSRIALLIQNRIALDEQSEMASHLEEHGLGESDCFPDDRKMQQYGNFFFILQSEPRHIATLCRLVSLSEIDTLLQTVMFTLYGNQYESREEHLLLTMFQNVLAAQFETSTEFGSLLRANTPVSRMMTTYTRRGPGQSYLKSTLSKKISDLVSHQDLDLEINPVKVYDQMITQIEKEQGCLPADLPRSVTPEVAASNQDVQRIIQPRLEKLIEIAEGFLDIILSSTAQVPYGIRWICKQIRSLTRRKSPHASENSVCSMIGGFFFLRFINPAIVTPRAYMLLDTVPGNAPRRTLTLVAKMLQNLANRPSYAKESYMLPTNPFVERNKQRINKFLNELCEVGDFYETLEMDQYMALSKRDIVISITLNEMYNTHALVERHLDVIAPKEKDHLRILMTELAPAPAQVSRKENKTIDLPLFSRWEVPIQDLTTALMSENNITQNDILYMETKAIYVQLIRSLPHLASGPLDLDYIAEVAATTKDAQLVRKGIKVKDMLKELEDAGVIDHKDHYKLLVEEITQELTHLGNLKEKVLQEIESLEGVYKTILDHNNYLRSQLESYKAYLQNVRIQSGGDKSSKVGIGVEVEGGHKPKKTHKGSAKGPCKFSHNHLEKDGVITESTVPENRRANIFFSISSPLPGTFIIAMHFKGREKPILEMDLKLDDLLEKQQDNVELLDLEYVRLNVSKTLSLLNKNFVNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFZ6</accession>
    <name>A0A367JFZ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001429">
        <property type="protein sequence ID" value="RCH88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFZ6"/>
    <dbReference type="STRING" id="86630.A0A367JFZ6"/>
    <dbReference type="OrthoDB" id="2244878at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="52694" checksum="EA524C221452A523" modified="2018-11-07" version="1">MEKSNHPKAEYIAVPTEEVTVYEEQPKRCNAKRFIVFFLKGLLGALVLLTLVIPGIDRLSQRMFGSETEHFEIMPYDSFNPNVPELREPCFLRHNDNYAELNEFMDELHQTMGPLPSPSSGPHHHHRHHRHGKHHPAPPGDERLDFDDASTDILQLSKDKDKKEKHHWKPFCKLHKLEAESTVFAFKTDDYKKAKFFLNGHFNRGGHVRVSKSKDASVDFVKVNVTIYAGRSELRSEAQISAFEHEGDYVVQLERDPKHPPPPFPFPPPHHHHRHHKPKQEDCLVYSVDIEFPQNTEYYEELQFHVKQTQRIEGGHGIEEISFGTIKAGLGRGAIIFDGLKAKTIKLGVLRGVVMGNYQPEEKFLAGSVHGATKVKLEPTGEHFNVTAASTFGPASVDLPADSFSGDFGLFHFFGPAPTIEAPNPEDIHVTKLKHGVKAGYYKEEHTGSRVIISAKFHGAPALYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI84</accession>
    <name>A0A367JI84_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001261">
        <property type="protein sequence ID" value="RCH89596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI84"/>
    <dbReference type="OrthoDB" id="10323731at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="133" mass="15280" checksum="582CE86DA6F8D7B1" modified="2018-11-07" version="1" fragment="single">IMKGIKLQRDLFDPSKPQKPLEWKRTGWKRPSDEAQSSQAVIAESSQAAQKRARTTNERGNELMETLQQQFENTLTLRIEKYIDKDGNLQQLKETCLIETRLPRGTVTGAERQVGAKATELERILKKRKTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIB8</accession>
    <name>A0A367JIB8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001254">
        <property type="protein sequence ID" value="RCH89625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIB8"/>
    <dbReference type="STRING" id="86630.A0A367JIB8"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016484558" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="283"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="438" mass="49337" checksum="2C5697DC3EE1DD83" modified="2018-11-07" version="1">MRSITSLIVLFVVSCLAFIADATSTTGHRVLVLLDSLSDKDSYTQFWQQLQGRGFDLVFKSADDPTTSLYYFGEQIFAHIIHFAPKSNLASHPQLNNVQLVNYVQKGGNMLIAVSSDVDDNVRALVSEFDIEVETEKVFGHTQFVGEHDLIATTNVIAPASVIEKKHMEAPILYSGVGLTVGNNPFSTAILNAERDAFVAESYQKRADTSHPVTLVGALQARNSARVTVVGSLDIFSDKLISSAVNIDSDHTFGKSGNEDFISHLSQWTFQEKGVLKIVGHYHHKENEMEQRSWYRLKDDIVYTIDIAEYKDGQWVPFKANDIQLEVIMLDPYIRTTLKQVQNEDTVGRFEAHIKLPDVYGVFTFKVNYKRSGLTYLLAEDQVSIRPFRHNEYPRFLTAAYPYYTATGSMMIGFIVFSIVWLSTWGGSDLKKKNTKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK34</accession>
    <name>A0A367JK34_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001183">
        <property type="protein sequence ID" value="RCH90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK34"/>
    <dbReference type="OrthoDB" id="2272123at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="8936" checksum="9807E8435538074D" modified="2018-11-07" version="1">MNMSLCLYCEKQLLDESASFCSLACQINEASKPIHHILILFNRRNQFTLYRASTLHYHSHILALPDANTRNNSPCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKE1</accession>
    <name>A0A367JKE1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HTB1_2</name>
        <name evidence="14" type="ORF">CU097_008983</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001138">
        <property type="protein sequence ID" value="RCH90339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKE1"/>
    <dbReference type="STRING" id="86630.A0A367JKE1"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="119" mass="13016" checksum="FC6A4654F51603A4" modified="2018-11-07" version="1">MAPKESTSAPAAAPKAKTGDKKKRLARRETYSSYIYKVLKQVHPDTGISNKAMSILNSFVNDIFERIATEASKLAAYNKRSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKF1</accession>
    <name>A0A367JKF1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001136">
        <property type="protein sequence ID" value="RCH90349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKF1"/>
    <dbReference type="STRING" id="86630.A0A367JKF1"/>
    <dbReference type="OrthoDB" id="2289451at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="39580" checksum="7D5DC8760F3C9DB4" modified="2018-11-07" version="1">MSSRQTTTTSEERTTISTEPATTSDTTTVAATTTVTGTTSTPVDPTTTSSSIQTTTEHATSSTVNPSTTSSDTMSSRTTSQETQATTTTTAITSTVPHSPTTSAPPSTTTEAPSSTAPPSSTTPAPTTTTTSDHPTTTVEPSTSTLPPSSSSPDPSTTIPPSTTHVSPTTTTQDQTTTPPTTTTTAPPPITTTTPPTTTTTTVAPPTTTTQEPPSTSQAPTTPTTSLRYHTTSVTISTDITTETAIVVNGVTKTITTVIPTTTVIPTLAIDTSDPGQGSSTPTGSIVGGVIGGAAGVALIAAGLVLYKRRNRRQAVARSSEMYDDDFYGDPYRQNNEWMTGGRFTGTGEGRTSLDDEEDFYRSQHRRSWWSSVSSVFQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM12</accession>
    <name>A0A367JM12_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_000036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001076">
        <property type="protein sequence ID" value="RCH90731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM12"/>
    <dbReference type="STRING" id="86630.A0A367JM12"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="11">
        <location>
            <begin position="282"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="12">
        <location>
            <begin position="840"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1111"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1121"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH90731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1135" mass="129465" checksum="44A88CF1E3B08E9D" modified="2018-11-07" version="1">MGNDIISGVYDVRDTPENPFVIWWNDIEKDTRYEDWPSNIMEILKPTYPGQLHPIRKNIYNLLLVEDLASTASLSRIVNEIQTMIKRTIPIRFGLIAFVEDDNSASTLMARALYYFIKNNGKADAIQFLETILELTSSNGLDRATTEMIERAFNGHMSISHENLNSEQVIDQSQAFITATRQFMKRMGISQLKPNEGIMFMNGKLLEFDEERPWIHSLMPHLTEQTRFIQTMAYNQEFDPDLDYYEYTLSQPNVVQKRNPYILVSHTNPLRMHTFDAITASKGLKYFQNDNESLVKTNLWVVSDFDTANGLKLLLEAILFAEANPKVRVAFIHKSIHKVSTKDTNDTKFSDLLCKLIYEQDTNLTTLKEILQNTNLFAGIDGYSSQNPGEVTIQINGDGLEPVPIIPGTPITEMVAKAQREKWSNLNTALVKDGLEPDFTGIIMNGRVIGPLSLSENIQFTNQDFEILYQYENTKRIMHVEKAIVESGKDLQNNTSDAVMKLTAIIENDKAQATQDAIESREPVHRIRQYQKIPRTQYTQFIAGGYSDDTFLEIGLIIDPLSEAAQKIAPIVHTLSEIEGVSVVTYLNPVSTLQELPLKRFYRYVFDKEPHFDTITGEKQVPTAYFANLPVKPLYTLGVETTNAWHVTVKEANMDLDNILLTSIPDNQHGVSAVYELQSILVEGHCLDSINKSPPRGLEFELISPSGLDKKDTLVMANLGYFQLKASPGIWKLALREGRSSSVYSIQDVGANGKWNWNTEFNGSKGIDDTLALISFEGLTITPLVHKNPGMEDEDVLEPAQPKSKKNAGGLWSSINQKIFGTKETENASSLANKATNAEINIFSVASGKLYERFLSIMMASVMKHTKSTVKFWFIENFLSPEFKDFVPHMAKEYGFDYEMVTYKWPAWLRAQHEKQRTIWGYKILFLDVLFPLSLDKVIFVDADQIVRTDLKELIDMDLHGAPYGYTPFCSDRTEMDGFRFWKEGYWKNHLRGKPYHISALYVVDLVRFRQLAAGDRLRAQYQQLSADPNSLANLDQDLPNNMQHIVPIYSLPQEWLWCETWCSDESLKKAKTIDLCNNPLTKEPKLDRARRQVPEWETYDKEIDELRKRITAGGSSSLPKQDEPSIKKHLKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMJ5</accession>
    <name>A0A367JMJ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PHB2_2</name>
        <name evidence="8" type="ORF">CU097_012589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001009">
        <property type="protein sequence ID" value="RCH91180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMJ5"/>
    <dbReference type="STRING" id="86630.A0A367JMJ5"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="44"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="297" mass="32553" checksum="5309A86F5753C10D" modified="2018-11-07" version="1">MAQQAKQAAQKLGGMFPGGSGKGIGSAAGALVVLGALGYGVNASLFNVDGGHRAIKYTRLFGVQDNIYNEGTHFMIPWFETPIIYDVRAKPRNVASLTGTKDLQMVNITCRVLSKPRVDQLATVYRTLGQDYDERILPSIVNEVLKSVVAQFTASQLITQRERVSRLVRENLVRRALRFNIILDDVSITHVGFSPVFESAVEAKQIAQQEAQRAAFIVDKARQEKQSVIVRAQGEAKSAELIGEAIKNKPGFLELKRIEAAREIASIISRSGNKVMLDADTLLLNINSTSEKSNVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN70</accession>
    <name>A0A367JN70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_011124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001014">
        <property type="protein sequence ID" value="RCH91141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN70"/>
    <dbReference type="STRING" id="86630.A0A367JN70"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH91141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="454" mass="51696" checksum="8CABF62769A3B36D" modified="2018-11-07" version="1">MTPDIWTQLKNEIHNKLVTYEYVDATDFIVGLMRVGKNPEELSNELQSLVGSDYDPNVTQWFYDRKRALENPEIQKPTEPTKTIAQPETPKDAENEKIISKSQQGIDVQPAAEASDKDVAVEQNAPSKSIKLNKDSRIFSKAIGSALNLTPERSSRERFTQERRRERSRSPSPDPKRPRTMLRDDRHKNEESKSNDVFSRLGGSSSTKEVRPSVFDRLGTVNDVPAPKEENTKSQRCKYWPTCKNGEDCPFFHPTTVCPDFPNCPNKPNECMFIHPETHKKPATMIQPQFPAKLPYPCKFFPYCNNPVCPYIHPIPQQAYYMQSHSYGQRVPVPCKNGDDCTRPNCHFLHPKDPNPFAEIICKYDGACTRPNCLYKHTKENPKNKVLISKPDTTNRQFSVPEDQIEERIIVGESADIIKPETQQQERIKPTQPNETNGGMSSSMELDADAVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP67</accession>
    <name>A0A367JP67_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000939">
        <property type="protein sequence ID" value="RCH91659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP67"/>
    <dbReference type="STRING" id="86630.A0A367JP67"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF4">
        <property type="entry name" value="ALPHA-1,2-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="627" mass="72292" checksum="CD6C2C748B9A4626" modified="2018-11-07" version="1">MASSDLPFPNSTRNDSLFGGARLGRRKRTVFLLLLFVVFFVLWFNSDLNRVSNEVHNVSQEDQLADKNYRPVEPVVEDEVIDDEPTTAQDDIESTYDKPTQAQKPPVQPKPDLIIEEPTIAKNSHYKYFIIIASRVGNASRRQLIRNTYFGLQDNLEPCMKRDKGIQYLFWMYGDLPKAKTAERRMYETEKMEWNDFVKVKTDAYDQDAVLRWARDYLKRNEITFDYLVVQDGYSFTHLSYIQQTIDKEKNNLPDTASGTDMVWFNPQLKNVVVAGSSAFDKLWEYESDIADIADPASDSSLLVSLYRLNKAVEIQRKIIESESEGDRLSEFFKFPVFLGEQSRMITWSNNVETVPDLTVSVANVYQDADFASLTQKLRLGATSICKAIDKPDIAVVTSSFIYPDSCMEKAAPPAADNKREYALAHNYAFVARSTEYAQQDLRTEKRRTVWGKIDVVQKVLPKYEWIFWLDMDAVIMDPKHTVQGILDDLRSKYPGGPEKFEENIDLVIAKPTRDKMINAGVFFMRNTKWAQTFLKDVQNFKKWYNQSPSYEQGAMWELIQLDKHKSHVLLLDNDDHTFNTLPKRYTPGDFIVHFAPDKCPGPAVLEGLEAVKRIQNGEVFTHFEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPL3</accession>
    <name>A0A367JPL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NOG2_1</name>
        <name evidence="10" type="ORF">CU097_009192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000907">
        <property type="protein sequence ID" value="RCH91883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPL3"/>
    <dbReference type="STRING" id="86630.A0A367JPL3"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="206"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="666" mass="75862" checksum="8E2882AD2395D232" modified="2018-11-07" version="1">MGQYKKEKQRVTRDKAGGDDRAKNMRVKGENFYRDAKKIKYINMLKGGKAIRDSKGKIVQAAEYQSSEAKVARVAPNRKWFGNTRVIGQKALEQFRENLGAKVNDPYQVLLKQNKLPMSLLQDATKHTRMHILDTDSFSNTFGKKAQRKKPKIDIGSMEELMSRVDDTHENYKSDKDSSLLANKESDYTDASRAWYLQAGQSKRIWNELYKVIDSSDVIIHVLDARDPIGTRCKNVENFIRKEKPHKQLIFVLNKCDLVPTWVTARWVSHLSQSAPTLAFHASINNSFGKGSLIQLLRQFATLHSDRKQISVGFIGYPNTGKSSIINTLKSKKVCSVAPIPGETKVWQYITLMKRIYLIDCPGVVPPNSDDTEVDIILKGSVRAEKMAAPEDTIPTILERVRPEYLKRTYGLQGWENPTDFLEQIARKTGKLLKKGEPDIHNVSIMVLHDWLRGRIPFYTPPPESVEPLTEEQEEEKKKRKLGVEQIFGKINVTAEYMEDDLANNAQLIEEERAKENAKQEEEAANKKSRKSAAKQTTDWDEVFEDVVGEQGPVVKAPVIEGEEDEEEQGIDSELELSEDEGGNNDEEEEEEEEEEEEVEEQPAKKVKINNNETEVPKKGKIGVHYYETANVKNKNRNKVKPDDEKKKVLHSRLKGSAVAGKRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ67</accession>
    <name>A0A367JQ67_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000913">
        <property type="protein sequence ID" value="RCH91841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ67"/>
    <dbReference type="STRING" id="86630.A0A367JQ67"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="269"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="486" mass="54386" checksum="D53EA4CBA55E7F5F" modified="2018-11-07" version="1">MSKPYLSRNGHLFDSMLEIKMENDQLKHCLRQLLTLSKQTTSNEKRDTQLPAFFWSDEEKNTSLEDNKINDAKNDHSLKTSPSPLSPIAYSKLAISAGSSSNMPREPSISSQEEWENLRDAHPIKKSPGSAILTTPAGNQIQNQTTVSLQPLLVDDKGDIPIKKSNLVLKRASRSSLGSTFVMIVEQLHHRNGEKDQTVLKLKEGMTSDTDAVLLKGIEDMNRQPITKSLLFYVANQALSAIPQCQVALNDDNTAEKSKFYKIYDELPSLPDFVDLVVKRAKTTPGTLLGTLVLLDNTSKMLPSTARGRPCSPYRVFLASLILASKFLNDVCPKNLSWARYARYFCLTDINLMEKQLLILLQYKTFMKLNDIIQAYNGFLLFDMSQILQQVEYSVNMAASSYYKPFQQQAFITQTTDQQDTILSDDHITSYVVICPDTTKNELIETISEAASSSSSISSDLCFTYSTEALVNGTLEHESTSAARIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR29</accession>
    <name>A0A367JR29_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000870">
        <property type="protein sequence ID" value="RCH92151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR29"/>
    <dbReference type="STRING" id="86630.A0A367JR29"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15595" checksum="766659A833779C21" modified="2018-11-07" version="1">MLAACRNDQDEMLEDILKEGDFDINYTDGLGDTACHYAAKFGAKNCLELLVHISSIDLNRKNKEGKTPLHLAVQYDDDPDIALDMVDLLLSSGADPRIKDNQGSTILDHVVNEDMRDLIEQSLAGYNMGMSDNDDEDEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS42</accession>
    <name>A0A367JS42_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RRB1_1</name>
        <name evidence="7" type="ORF">CU097_006594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000788">
        <property type="protein sequence ID" value="RCH92726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS42"/>
    <dbReference type="STRING" id="86630.A0A367JS42"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH92726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="475" mass="53413" checksum="55510E263977A808" modified="2018-11-07" version="1">MSKRQADQPDIREQSKVSSFEGRYGKEEKNEMGEFEDNWEDEIEEEEVIEQQEEEEQDGEGMEVDDEEEVQPDLKVYLPGQPLAEGEVLEADPSVYVMLHNLEVHSPFLSFDILQDKLGDERKNFPATAYIAAGTSIPGVRDNEVLVMKMSSLHKTQQDDSDDEDDPDALDEDPVLEHRSIPHNGCVNRIRLMPYAQEKHIASTWSETGKVHIYDLTQAVDSLEVPGTPAKMSQKPLCTINQHGRDEGYAMDWSRLDVGRLLTGDNSGKIYQTVLTPTGVQTDSVAFREHRSSVEDLQWSPTETTVFASCSSDQTVKIWDTRNKKRSAVSVHASSSDVNVITWNTKAAYLLASGHDDGIFSIWDLRTFKSNNGKPTPVATFKWHHAPITSIEWHPTEESVLAVSGADNQLTLWDLSVEPDTEQDGQMTHEDVPPQLLFVHQGQEDIKELHFHRQIPGCVISTANTGVNIFKTISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS68</accession>
    <name>A0A367JS68_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MEAF6</name>
        <name evidence="11" type="ORF">CU097_005739</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000778">
        <property type="protein sequence ID" value="RCH92793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS68"/>
    <dbReference type="STRING" id="86630.A0A367JS68"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH92793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="22707" checksum="CB5C0FE4C9302D05" modified="2018-11-07" version="1">MADAKEQSTTPTTTTPTTTTTTTSTTTTTTPANNNNNSNNNNNNNNTTDTPAEPPQVTRQKYEEAKQELQALLARKKQVDTNLINLEHAIYLFEGSYLEDTQQNGNIIRGFDGYLANRTDRRKPKFTELDRLFSLSSSTYQKALAQKEEKDQDSSQDDRSVNSAAGSLSARREKKRKMKGQDGINYKKKKLSAGRDSDDDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTC4</accession>
    <name>A0A367JTC4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000732">
        <property type="protein sequence ID" value="RCH93168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTC4"/>
    <dbReference type="STRING" id="86630.A0A367JTC4"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF122">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="35054" checksum="820E4CFBD60FF5D1" modified="2018-11-07" version="1">MSRLPIPSLAELTYNVNKLSQPNIYLYHQPQPHHHPLSFQPSSSTVHHDYPPTPPQPPLTQRFCESEPENDRLLLKQVYEQCTVIHKEIARYRVDALTETDRNKIVDLVYCTTESMMRSLKTLNDQLFQYHDQEIDNTFPSSQPIRSLQDDPNSSKYEMIRQARNLQDSSMRPKYRRRNKRNMIGQRCHSCNTTETPEWRRGPDGARTLCNACGLHYSKLLRKGSLTVQTHNYLLDSQSAEMKKTPRVIQFPIIQIQAQKKDNRHHMDRNNSGSSSNSNNDNNNNSTVASNINNHSETLDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTJ0</accession>
    <name>A0A367JTJ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DGA1_1</name>
        <name evidence="17" type="ORF">CU097_006512</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="PJQL01000719">
        <property type="protein sequence ID" value="RCH93260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTJ0"/>
    <dbReference type="STRING" id="86630.A0A367JTJ0"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH93260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="337" mass="37892" checksum="13D7222D49A8189E" modified="2018-11-07" version="1">MIKIQWAPLRGIPLERRLQTAAIVCWLSLIGGCSLLFTASLTITVLWPLHIAYLIYIWMDQSHEKGGRRSERFRRLRIWHYFANYFPVSLVKEADLDPSKNYIFGYHPHGIVSLGAVANFVSEATSFSDLFPGITPFLLTLNSNFRIPFYRDILLAIGMASVSRRSCNNLLSSGPGTAIVIVVGGASESLKARPGIADLVLKKRLGFIRMAIHHQASLVPTFSFGENDIYEQIDSSNNGLILTLQKTMQKIVGFTMPVFYGRGIFNYSVGLVPFRHPIVTVVGKPIPVPKLEPGQTEPTKEQLLSTQALYIEELMNIYNKYKDIYAKDRKQDLQIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUP1</accession>
    <name>A0A367JUP1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aureobasidin resistance protein Aur1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">IPC1</name>
        <name evidence="7" type="ORF">CU097_012779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000666">
        <property type="protein sequence ID" value="RCH93702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUP1"/>
    <dbReference type="STRING" id="86630.A0A367JUP1"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="144"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="385" mass="43176" checksum="F9A19C0257D45D78" modified="2018-11-07" version="1">MMKLVPKCHQIQYIFIAALLLIDFIIIQAPTIIPRSILAALLLSSFWIPYIRKFTLPALPIFTWLITFYACQFIPIDYRPNHIFVNLLPTLERILYGANLSEVISKHTHPVLDILAWLPYGVIHFSFPFILALLLFVFGPPGCLKVYGAAFGYMNLAGVLTQLLFPNASPWYELSYGSAPADYSIPGEPGGLIRIDKILGLDLYGSTFGSSPLVFGAFPSLHSGSATIEMLFVVYLCPKLKPLAIAYVMWMWFATMYLTHHYMIDLVGGSIYAIVTFAVAQNFLPSINPECRTRMQYLGATKLSIRSLIYSIEHDDVVQEQITGDEEAALLKHRPEPLVLSSDAYNTAYDDTYSPTSSVYTSEPDSPVTPHSPILNQFDFTKYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVS1</accession>
    <name>A0A367JVS1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000627">
        <property type="protein sequence ID" value="RCH94030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVS1"/>
    <dbReference type="STRING" id="86630.A0A367JVS1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="40"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="120"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="778" mass="88530" checksum="BFAEF0E1B72C4DA0" modified="2018-11-07" version="1">MADLTIPTPPRTPTELPTPSSSSASLKASFSNKSTSIKENVQVMVRCRPKSKKELEEEPCWIIDTRQGTIELARITSTARSFQFDNVMMGEGNEQVYKAGIQDLVRSTMMGYNGTVFAYGQTASGKTYTMNTNLSCPSGTEKEPGVIPRAVEEVFSYIEEDTSGREYLLRVSYMEIYNERIKDLLSDENTNPEIVEDRKKGNYVRNLKEEIVKTSQDVINCIKKGEGNRHISATDYNERSSRSHTIFQLMIESRPKSIGSKTNIVRFSQLNLIDLAGSEKVTSDVERRKEGAYINKSLLTLGNVISKLTSDSPPMHIPFRDSKLTRILQTALSGNARIAVICTINPTFSSKDESMNTLKFAQRAKLIKTDAKMTKIGEHSELQKYLRTIAELQTRMQEKNDLETETKKRLENLLSLILTSSKGTNKDEERDNFQIASFVPKDCTIEEVARRCEEGFAAKCEAHTREMQRKREMIDQLESTVQVLESINSQKAEILAKREAQIELLNKKLHEKSTTSVQHLMAAFQKAGVEQPQVQRALETLFLSVHPEDINKSKDIITQSIIQQQQKQAQQQQQKKQKEQQKGHETEQKLEQQVEQQANVQADSQKKSQANTQTNIQTDTQAEQQADSQEETRTNSQAEQQTQSMTTPLAEQQANPLVTQEEHQAEQAIYTKPKVSPQLFISIQEACTYCPLPAFTIYQPIEEYSCPDLVEDGNASDTTEHGHSRENSFWEEQSYKTDSEVEEIDKVYSPYAEHIQQTLFYLPNWILVAWCIFYLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWK9</accession>
    <name>A0A367JWK9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_012839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000593">
        <property type="protein sequence ID" value="RCH94297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWK9"/>
    <dbReference type="STRING" id="86630.A0A367JWK9"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="538" mass="59680" checksum="4AFA0729D647516B" modified="2018-11-07" version="1">MTGILLMPSFQQDMVNVDDGTSSVMISALMAGTVIGAIFSGPLADAIGRKALMALGIIAFIFGNVLQVGADNLSTMYGGRSVTGVSIGMLSMAVPLYQSEIAPKNMRGRLMSIQQFTMTLGIAVAYWIDYAFMDVDESTGWRLAIGIQLIPALFGLIGLLLLIPESPRYSIDKKHTTQALHTLAKIRGDGTITHNAALMEFVEMKQNITFEHKIFKNEKYKRIFFSGPENNRRRLLLGMGVQIFQQLTGINAILVFAPQIFKAAGLSGKGVALMANALSGSINLLATIPAMIFIDKWGRRPTMIIGAIVCCICMGIMAILAGRHGYGHDAVTTESDTGDSMSMIDQKNPLVLLFDTNAPTIGFLVVMYVYVAAYSCTWGTLGWVYPAELYSQGVRAKALGISTAFNWITTYAVLQLTPIMLRNIEWRTYVLFCVMCLIIAIIVHLYFPETSGKSLEEVDLIFSCRFNYYDVNVHHPQTAAEALAQMEKVQQRDKNLYRFPFTPERSFSTNSHHKRSTLLPQYHQPSYVVKFPQDAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWL6</accession>
    <name>A0A367JWL6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_012750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000585">
        <property type="protein sequence ID" value="RCH94374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWL6"/>
    <dbReference type="STRING" id="86630.A0A367JWL6"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="185" mass="20641" checksum="49CBB8E4B4B574FC" modified="2018-11-07" version="1">MIVVAYSSDRHRDRAYHAAAGALICLIGYIILVVCIERPTLYAGACIAVAGIFVINPIVNAWLTNNIAPDMKKSVATAMAVSANNSAGLVGSNIYRKSDAPRYCKCVSFMNKVGSLSLLLVRGHMINLGFLVLFIILTMVQRYLLYRKNQLKEQEKMKLTEEQIEEMEDNDARVGDEAMDFVYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWR1</accession>
    <name>A0A367JWR1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000579">
        <property type="protein sequence ID" value="RCH94432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWR1"/>
    <dbReference type="STRING" id="86630.A0A367JWR1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016751653" description="Defect at low temperature protein 1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32353" checksum="93E26D9FAB15C951" modified="2018-11-07" version="1">MNSAKWPHYLYTASLFLLISLSALCIAISAADVIIQALTDRTSTGKLDFRNLAVVGGSYVLLSNDICETINAKYTQVTYSNQGTESTKSTPLFEGLDFKQAIARTPAIVENVACNIDPSYKRPMYCPVRQYIEFLIQEGLIDRELGTVYVQGYEIARFSRDPLSQEQYIDIMKHLAAILQNMGYNIKNSDGQVDETESMINSDHRTTGSSSNQSFRLYNLISRNNRLRSVDDTVSATQSMNTWHSRSTHFHLDEDNYSAYDEDEVRQDIYELLTRNGNNSNRHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX23</accession>
    <name>A0A367JX23_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_009743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000603">
        <property type="protein sequence ID" value="RCH94211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX23"/>
    <dbReference type="STRING" id="86630.A0A367JX23"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="50"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="250" mass="28339" checksum="51FE58D91F07D141" modified="2018-11-07" version="1">MSASISDSRQETTITEIIKINANSNFYLTYKSTETWPNKRDGYCRILILDSSFNPPTRAHANLLHKSIQTYPPGHFDALLLLLSTKNADKQLTGATIVQRAQMMELMAARYPNSAVGLTPHAKFVDKAAHIQAWLPDVRLELYFIMGYDTIVRLLDPKYYMPRPVMEALGPFLNTCHIICADRGEDEEQKAFWSKLELGTCSIRRIQLDPAFATLSSTMARTKIMQGQSVLDVLDPDIAQFVQDHHIYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXT2</accession>
    <name>A0A367JXT2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000545">
        <property type="protein sequence ID" value="RCH94728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXT2"/>
    <dbReference type="STRING" id="86630.A0A367JXT2"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38986" checksum="51E4790A3ACF82DF" modified="2018-11-07" version="1">MCPALSPRPAPTSAHDLRPDDIKVMGALGDSITAGFGIMGVNLSQPPLLAAFNSFNEYRGLSYSIGGDEGALTVPNYVKHYQPNLKGYSIDSHIALYCSGKEDEYVERKNIPEKDRLNAALSGSLSINLQHQLDYLIPEMHNIAGIDFQNDWKMINIQIGSNDMCSSCDSRYTNITTPDQFASHMDAAIERIVTNVPRVLVNVIGAFNVSQLFPVTAGQAYCRPKNNDTSTIGNRRECSCGSTPGGLEHMDYLAVEYNKRLFGIYQKYQQNKNDSFAVVYQHSNLNMTSFPINFFSNIDCFHPGIVGHQWVSKIVWNELFQPQAKKPSVFNFNANQTIYCPTDSDRIATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ68</accession>
    <name>A0A367JZ68_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000488">
        <property type="protein sequence ID" value="RCH95233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ68"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="55" mass="6125" checksum="E4DD033444C08886" modified="2018-11-07" version="1" fragment="single">MPIAFENFSLTEEIHQLVILPTIVEALCFVKTLIANRLILATVFAECAAHAQEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZH0</accession>
    <name>A0A367JZH0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000479">
        <property type="protein sequence ID" value="RCH95318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZH0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="335" mass="38468" checksum="2365480DFB055F20" modified="2018-11-07" version="1">MKIDYPTYRTHKTISFKEFIQLVKYCPDVNTLIGSRELFANCFSSYLLAIGNSIKWNIRQLCFLSEFELKHYYKYKDSIINISELQEAPDLQFVKSFPMLKPLALSSNLPLNYNFYANINIDEDIDARTILGPCPSLISIHFNSHGPFISGTVIDFITTRFVNLCDISFTIIPLPLCRPLFATYGQLLGFLMQAPKASFSLEMSIEKEEEGQDFEIISNICEYFNNYVRAKSLVDSCYSQTVSIKTTLESSTKNRPRPDRLLDDPFALDIHELCIESPAESTKLSRSTSFFIKRCHQLQELQLSIHLLSFYGYVYESLHILRIDAATADVGFFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZS9</accession>
    <name>A0A367JZS9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000472">
        <property type="protein sequence ID" value="RCH95389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZS9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="98" mass="10895" checksum="E5A0B889E9668216" modified="2018-11-07" version="1" fragment="single">PRPPSSPATSIRFCNTNQYVLYQQLLVGLCLFSGIVVLKRSVDQEIFASNSQDKFTQMPCSVLLSSGRLNVMDQRCVAYCAVCVTRNATIFGVNTFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZX8</accession>
    <name>A0A367JZX8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000455">
        <property type="protein sequence ID" value="RCH95542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZX8"/>
    <dbReference type="STRING" id="86630.A0A367JZX8"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="23005" checksum="A7A479F7DF5FEE1E" modified="2018-11-07" version="1">MASVYNRLLVQSRRLVNHNLISRQKLFTPSVVCTQKRTFFVNVPKFDRIADAEEQIRIGSDYLSKGSIDMAMNSYHKSVQIAPSGAGYFNIGVCYFQMGKYKDAIQSFERSLEYTPNSADAHTNIASAFLMLRDTKQAIRHLEQASNFNPLDGEVQYNLACVYEAVGRLDDAKTRFERAEILGIDKAQTALKKLEKKMTDTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0B8</accession>
    <name>A0A367K0B8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000445">
        <property type="protein sequence ID" value="RCH95654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0B8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11993" checksum="414C8A2F21A6094D" modified="2018-11-07" version="1">MRMLTIVLVSFFVYFFSIMAHWNIFKKKKDKDQSKEHLQQVLLSPPPMPSQSRLQEPPPLHYWSRQDNHQMMRYTWPNTIEIIEPYSNLPEDALRLSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0P9</accession>
    <name>A0A367K0P9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MPK1_3</name>
        <name evidence="11" type="ORF">CU097_010157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="PJQL01000438">
        <property type="protein sequence ID" value="RCH95719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0P9"/>
    <dbReference type="STRING" id="86630.A0A367K0P9"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH95719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="410" mass="46824" checksum="A8BC593104A9ACCF" modified="2018-11-07" version="1">MKYHNLPCYGQSFEVYEKYAFEREIGKGAYGIVCAAVNTKTGVSCAIKKINKLFERPILTKRALREVKLLEHFNGHKNIIGLYDIDIVDYNNFNEIYLYQELMEADLHQIIQSRQPLTDEHFQSFIYQACCGLKYIHSANVLHRDLKPSNLLVNTKCELKICDFGLARGYIDPSGGQTDAGFMTEYVATRWYRAPEIMLGFKSYTKAIDMWSVGCVFAELLGGKPLFKGRHFVDQLNQILYVLGTPDDATLCRVGSERAQIYIKSLEKFQKIPLSQLYPNASPTALDLLEKLLTFDPSSRITVEEALEHPYFELFHDPNDEPSHSTLFDFSFESLDTIEDMKETIIEEVKHFKARKHSLKIDMKGLRRQHSITTPTKANGSDCTFGYANELIASPVEVDPHLERDLSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0Y3</accession>
    <name>A0A367K0Y3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000425">
        <property type="protein sequence ID" value="RCH95864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0Y3"/>
    <dbReference type="STRING" id="86630.A0A367K0Y3"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="31965" checksum="2A0C7E6059E1C06D" modified="2018-11-07" version="1">MSFNDLEQGLGVSSNLNRNRLGEDGHDLEYKKLTQRVSQQVFHINGNITSIERLVGFLGTSRDTPDIRNKLHDVTEGTRELIKDTTNDIKSLSQYQTTVGSKSRQRKLEQQKLSKDFQKVLAEFQKIQRISVSKQREFVDKQKATTTALQAQVEDEQGHQEQQQIEDTQRRIQLEALDNEIEYNETLISERETEIQGIEQGITELNEIFRDLGMLVNEQESGIESIYGNVLNISHNTKQASEELTIANRHQKKARKNMCCLLLIITIVGCVLALIIVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1N2</accession>
    <name>A0A367K1N2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000400">
        <property type="protein sequence ID" value="RCH96113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1N2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016720086" evidence="2">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="14061" checksum="5B781C4E58D5F420" modified="2018-11-07" version="1">MHLYSLTLFASLSALYLFGQPAFCKPAPQYYPPQGYSPQGYPPASPQYPPGQTPPQYPPGQTPPQYLPGQTPPPTSQSLANPLDSVTSGLSNVIQVDLSKPAALPGLPAVAPLPGIPSGPTLPDLSGALGGAQQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K293</accession>
    <name>A0A367K293_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000411">
        <property type="protein sequence ID" value="RCH96011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K293"/>
    <dbReference type="STRING" id="86630.A0A367K293"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="426" mass="46687" checksum="961476746EF2C8A1" modified="2018-11-07" version="1">MAVPPKPFASSEREVKEEVKEESDVKSPTSPNQPSFADEPASQPPAPEQEAAPSTPPSIPKRQDSVASASSIPSPSPVAPVDVPEAQIPPTIPTRPESISDNTSSPPSIPKRQETASSTHTSASHAELLSEESAVPEPKESPVVAEEVIPVTNAQTEEVLVPESREIVEDQVEKAKEEVQKGDIAVETPRVESELLTSEESVAESKEEEAAVEPKVEKEEKVSATEEGKETDEQSEEKKGIEILPSGPKLTTPTRARIGVPRRSPQLKNTEPSQTEILQKQIAETPEEEKQPAKATPSPPAKPVKPIFAKFPTPFAVGGGEEISKKMLKPTQVRKPWEQEEKPSETEESEAPRPVGVRSIASRFNVSNNSGNEVLETKLKNHTKNEVEKVRKEFQQLLQEEQEKRAQLEGLVHELLERINQLENKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2Q2</accession>
    <name>A0A367K2Q2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-protein fam58a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM58A_2</name>
        <name evidence="2" type="ORF">CU097_014660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000367">
        <property type="protein sequence ID" value="RCH96457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2Q2"/>
    <dbReference type="STRING" id="86630.A0A367K2Q2"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="257" mass="29546" checksum="FAD0898530214F27" modified="2018-11-07" version="1">MKTKRPIRTAATAIIYYHRFKAFISDKEKVIHVDGSINAEDAINANEELLATTCLQLACKATEVPRKVRDLVNVGYRYYHSDGSTLDVDESYFKMRASLVTTELLLVRALGFDLEVELPFAYCLNVLRGLASIRYFMMDETKKYSRKQQHYPPAQKEIWKRMETDMSPEMSAIARLAWVYIWDSLCSPKIALSHPVPVIGLGCLYLALRTLQTEMSMNMNEYVDLWGASENMSVQAVRDFITDFLEFHDRISLSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4T0</accession>
    <name>A0A367K4T0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000302">
        <property type="protein sequence ID" value="RCH97159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4T0"/>
    <dbReference type="STRING" id="86630.A0A367K4T0"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016811619" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="119" mass="12270" checksum="5AC1E303E285DC28" modified="2018-11-07" version="1">MKASFLLASLFATLLTTQAAPLEARSSMSGSGTYYDVGLGSCGHKNSNSDMVAALSSDLMDGGKLCGKSITVKGKKGSVTLTVVDTCPSCDSGDVDMSSAAFKKLGSLDEGRIPITWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K561</accession>
    <name>A0A367K561_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000284">
        <property type="protein sequence ID" value="RCH97353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K561"/>
    <dbReference type="OrthoDB" id="2290293at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="230" mass="25971" checksum="5233D1E84F88E53C" modified="2018-11-07" version="1">MLTFRVGPNAASLYLPRPTEWAGGSKSDTVYVANVSSTSLPPILIEVQHTITIEFIDRLINYSLSVKKCFKAKPIVIVFGTHATRNEISMDFEPTTFEFAKGIPSKHWAEKCYILDKNTITEATKATPLPAMDDPIIQNYVQLLKSRRRLEFQQKSHDGLLYTETCKRMYIGESDSLVEPMPSPPELSELAKSLVNQSSSNIDILCAEADLPKTDMEYVQQFKESEEKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K668</accession>
    <name>A0A367K668_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar sorting protein VPS33/slp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SEC1_3</name>
        <name evidence="2" type="ORF">CU097_015194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000262">
        <property type="protein sequence ID" value="RCH97629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K668"/>
    <dbReference type="STRING" id="86630.A0A367K668"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11497" checksum="4A170BB692E14C55" modified="2018-11-07" version="1" fragment="single">MSSIVEIMRKRLMDSIRSVQPPSKWKIIVVDSKSTHILNAACKMYDILEENVTLVENIEKKRQPYPSLEAIYFLTPCRESIYRLVDDLSSKPPTYKVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6S6</accession>
    <name>A0A367K6S6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000241">
        <property type="protein sequence ID" value="RCH97878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6S6"/>
    <dbReference type="OrthoDB" id="2238774at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="17372" checksum="4ABD757ECE3E451B" modified="2018-11-07" version="1">MEEEEHELTRIEKIEHEHKLVQRKFHKRNEPEKGGYATLSDYWKEFGHVVQHTMHLKSSSSIQLLLNLTGEFHDVCDAYERDAEIYEYKECFDALDFAWQTVIEDHQPISQTDKVRILNVLRDGQDRASLFGLNQVYHHATEMLDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6Z3</accession>
    <name>A0A367K6Z3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING finger and SPRY domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSPRY1_3</name>
        <name evidence="8" type="ORF">CU097_012720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000232">
        <property type="protein sequence ID" value="RCH97994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6Z3"/>
    <dbReference type="STRING" id="86630.A0A367K6Z3"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF6">
        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="325"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="665" mass="75413" checksum="FB477B00E7322901" modified="2018-11-07" version="1">MANSVASSDDSFYHFTPADEFSLQIAHIFKIIDRHWKKLMSISMNHVRVRRPSDEDDHSRQEEEIKRAFYEREKIMMQCMEVLLEAVREGTGFLALLSVLVLHLRADNPVSLAFMHHVFEKASLPALDTMDHASEMIIGKLNKRPGRLQRMISLLCGRYREAAKKELVRKQLINHWVIDNFMRPIVDPMAVRTRQNAAIVWALLAKKYAGEMACHIWTEEVGDILIKSLANPQEDVLVRLFCLVALERFALTAYCKDRIYHHDLNIHELLLAIVAECNEVLQRIHLLNTGKAQTPTQLNVPLAGPLRDEWAKYIQLKSCCQWAVDHTFADPQVVNHSWDLSRLRMIMNPYDATSGLKMTDNGLMLRNDLNHFESVRGTSCVRKGKWYYEVVILTNGIIQIGWASHNSKFSPDDGHAVGDDINSFAFDTFRSAVWVAGKCLYPVSILDTRCAIGDVVGSLLDLDNGRCTYYVNGKLMQMTVEFSCIPGINEHHFGPNGFGLFPAISVHGHQQVRVNFGDEPWIYKPHVNYPYWGASQAGVLDPAYRKKVKYWVHKRGKTRFSNAYCPTGGPVLRPPSVINVVPSHQAPPPVNDTSNVDDDNFDDIQSPQSNDGDDDNLCTICYAEPANVRLLPCKHQDIGVSCAAMIKKCHLCRHKITGRCILKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K762</accession>
    <name>A0A367K762_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SEC53_2</name>
        <name evidence="14" type="ORF">CU097_011803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="PJQL01000231">
        <property type="protein sequence ID" value="RCH98008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K762"/>
    <dbReference type="STRING" id="86630.A0A367K762"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH98008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="255" mass="29314" checksum="5694E4A83FEC9DF0" modified="2018-11-07" version="1">MMAIDSGFLDREQPDTIVLFDVDGTLTPARNFISQEMKDCLANLRKKVAIGFVGGSDISKQYEQLGSTILEDFDFCFAENGLTAYRLGKQLASQSFIQWIGDEEYNKLVNFILRYIADLDIPKKRGTFIEFRNGMINVSPIGRNCSREERNEFEKYDLSIRIREKFVEALKKEFSHLSLTYSIGGQISFDVFPTGWDKTYCLRHLKADGFKNIHFFGDKTFEGGNDYEIYTHPEVIGHSVKCPEDTMRILSELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7F0</accession>
    <name>A0A367K7F0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000221">
        <property type="protein sequence ID" value="RCH98134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7F0"/>
    <dbReference type="OrthoDB" id="2224699at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="234" mass="26898" checksum="F4F70F19ECE9F614" modified="2018-11-07" version="1" fragment="single">MARHFDYVKRVIERLTTAKMILNPEKCYFGKKAVYLLGYCVSKKGKSLDPREVTNISEWSLSQTCTFDSTTIVDSDNELEGSSNDEELPKSRWYIDDMDISKMLFDYRRSVITISKIIYDSQCGVPLLEMGMIKLLELSVKEGISIYEKKIIKDIACMLNFLPKREVNVTKLGEPELWSRYCNPLLTSMLSENENNVILRWTNKAADNYSSKWSDAIISAMNEEVCLGYGECKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7R0</accession>
    <name>A0A367K7R0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KHC-73_2</name>
        <name evidence="3" type="ORF">CU097_015027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000215">
        <property type="protein sequence ID" value="RCH98207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7R0"/>
    <dbReference type="STRING" id="86630.A0A367K7R0"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="232" mass="26150" checksum="3049FFBA75326E6B" modified="2018-11-07" version="1">MTGSTTASLESTSSQSSTNESSEIKVIRPSLPKSYTTPTCPPTERKERRSIAADTNDLELLLSMETQARLDALAEREKQKKQDDAVPFSRPTTIKFELPVTPPRSRSPNQRLTYPRARPTRSLPEEGLTANAKRKKRSSWRYLFGDRSDDDEEVTPYVTMDARVRLKLRPLPTFGYVRFIGGVEFGKGEWVGVELDHGVGNCDGSVNGHRYFTTDPRRGIFCKRHDLEAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K818</accession>
    <name>A0A367K818_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000203">
        <property type="protein sequence ID" value="RCH98364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K818"/>
    <dbReference type="STRING" id="86630.A0A367K818"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000284">
        <property type="entry name" value="Lysine-ketoglutarate reductase/saccharopine dehydrogenase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH98364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="918" mass="103298" checksum="1363BB4D39D9C93B" modified="2018-11-07" version="1">MLLNLIKGNHKFIHRRHYATIGIRREDKSRWERRTPLTPDHVKKLIQETGTQVYVQPSTKRIFPIESYEKAGAIVTEDLSKADVILGIKEVPQESLLPDKTYLFFSHTHKGNEKNMPMLQTILDKRIRLMDYELMTDEKGRRLVAFGKFAGNAGMIDILHGMGHRFLGLGYSTPFMYTSMAHAYPTLNEARLALSRVADMIERNGTPKDFGPLVYTFTGGGNVAQGAMEIFKELPHEFVPAQDLEKIVNDKNPNLNKLYAAQLDVTDYIVTKDGNRPLESHDEYIRHPEKYHSNFHQKIAPYTNCVITGAYWDKRYPRTLTNDQLREIELLKQKGVINKGKMMSLADIVCDIRGAFECLSHSTNVDDGFFYYDALKNEEHKNPEGNGIQVMGIDILPAELPVESSQHFSEKLYPFIKEMATQPGQSPLLRHSVIAEDGKLTEAHQGLKSYLSTTQKGPKKTVLLLGSGMVAAPLVEHLARRSDVNIVVASNVAEEAKALVSKFSNAESVPLDISDRQNLSALVGKADVVVSFVPAFLHTQVANVCIEQRKDMVTASYVSPEMQGLNEKAQKAGVLIMNEVGLDPGIDHMSAMKIIDEAKRKGSKIRSFISWCGGLPAPEASNVPFGYKFSWSPRGVLTASGNDAIYWNNKKEHIISGDNLLKQHFPVVRTPFAGFVFEGLANRNSLGYADVYGLGPLSDMDTMFRGTLRYQGYSDLLYAFRQLGFLETNPLSDCTNWKQYFETILRSPLTKESVTQRLGLSNDHPMTETVWSAMHYLLSKDNDFPIHMKGAAPLDLFSNLLAKRLRYEKGEHDMVAMHHEFGIEHSSGQKETLTSTLIRYGNDEHTAMAETVGLPAAMAVELVLDNKIPERGIQVPTQRHVYEPILEQLEFKGIRFTERVEPYRVNQLKPTGSGLYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9B8</accession>
    <name>A0A367K9B8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">URA6_3</name>
        <name evidence="11" type="ORF">CU097_015334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01000172">
        <property type="protein sequence ID" value="RCH98778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9B8"/>
    <dbReference type="STRING" id="86630.A0A367K9B8"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="33481" checksum="E3449801D4405AA1" modified="2018-11-07" version="1">MFRTAFLRNSRLVTSSNIKQRLYSTAGGGNKTGNAPSVPAMLAVASMGFAAYYTLVKSREGQSLPRKKNAAAVEQEEALKEQKLQDKLAKRDLETKPIPAFKPDEVTVVFVLGGPGAGKGTQCDNLKKDYGFVHLSAGDLLRAEQKREGSKYGEMINNYIKEGLIVPMEVTIALLEQAMKEAIANGQGTRFLIDGFPRKMDQAIKFEEVVVPSKLVLYFECPEEVMLKRLLKRGESSGRVDDNIESIKKRFVTFIETSMPVIDEYAKQNKVKKVHCDQPVEKVYENVKSIFDELFNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9E3</accession>
    <name>A0A367K9E3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWI/SNF chromatin-remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SNF5_4</name>
        <name evidence="7" type="ORF">CU097_013295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000171">
        <property type="protein sequence ID" value="RCH98786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9E3"/>
    <dbReference type="STRING" id="86630.A0A367K9E3"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="449" mass="50910" checksum="F855BC598A4AD15F" modified="2018-11-07" version="1">MQANLQAQFLQQQRLNAAAAAAAAAAAGGNTAGGVVPGVMPGQTPNPPHPWQDMVRMQTKQPFNLKPASSEAAQKTLRQYERRDDEYQAILNTQYKRHVELAQEKKKLIEQANLERRIRSQNPAHLFGPGYQSFGNGKTGFQPKIKYPAEKKRKQQVRFNFSTEALKEQADKEECLVPIRIDLEIEGYKLRDTFTWNLNETLITHEQFAEVICLDLRLPPSLFVEPIAKSIKEQLEDYNLSAATPQETDELKTIIKLDITVGNKELIDQFEWDIGCPKNSPEEFAEKLVTELGLGGEFKTAIAHLIREQIHVYKKSLLVLGEEEQQHEPSQMGNAIRDNQQAEIFTPAIIELTDAMIERMEKDQTRESRRKRRGTRSRRSIVTSNDLEPQKTHRTGFAAPPEQELTDEQYTGMGYDNGMSHFSTQRKSAIKARMNIAAEAQQDAALENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9R5</accession>
    <name>A0A367K9R5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6 7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6 7"/>
    <dbReference type="EMBL" id="PJQL01000156">
        <property type="protein sequence ID" value="RCH98973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9R5"/>
    <dbReference type="STRING" id="86630.A0A367K9R5"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="75"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH98973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="684" mass="75621" checksum="A6BD3426AFA5D3F4" modified="2018-11-07" version="1">MAKFSLDKQTYEVPNTRKPGQSGIYRNAKRPVVETTFSPKVTSIIDCFNYGLKISKDRPCIGVRSVKNVETGERGPYVWQTYRQINHRLTNFGSGLMNYLNHTMGETRTRQIPIGIWSINRPEWTIADLALAAYANYAVALYDTLGPDTVEYVINHAELETVICSGDHIADLLKLKHKLPNLKTIISMDSIDEVSRPGVASKSDIVKAWAAEKGVNLLDFNAIELLGKKNRRSYNYPTPDDLACIMYTSGTTGTPKGAMLTHRNFVAALSASQSNLGGNADDVCISYLPLAHIYGRISDIMILTVGGRLGFFSGDMNTLVDDIQVLKPTVFASVPRLLNKIYGKLVASTIQAPGVTGALARRAVAAKLANLEAGKGYTHPLWDRLIFNKVKQALGGNVRIMVTGSAPIGKDVMQFLRIAFCCDIREGYGATETCAATTVHYEGEYLAGHIGGPFTCNEIMLLDVPEMEYLSTDPYPRGEICVRGPNIFKGYFKDEEKTREAIDEEGWFHTGDIGMINERGAIVIIDRKKNIFKLAQGEYIAPEKIENVYAKDPIIGQIYLHGDSLQSSLVAIVVPDPDALNSLLAAKLPQIHAKKLSLPELCKLPEVNALVLAQMDRVGKLSGLRGFEFAKAIHLEPEPFTIENDLLTPTFKVKRPQAKKHFEAQIAQLYERVNNQAEPEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAI3</accession>
    <name>A0A367KAI3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000140">
        <property type="protein sequence ID" value="RCH99198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAI3"/>
    <dbReference type="STRING" id="86630.A0A367KAI3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="409" mass="48348" checksum="89F1C2F82125489E" modified="2018-11-07" version="1">MGLPYNSKERYDHYKYMLKGEDIEDLAVLMQRMNVNEQYTPQQKIRLQGYVNCCEPIFFGFLTTLVSERPKYDIYVSFLKDDFTYNPYAFAFHISSDINLSEELTYCLNKSYYQKDKTQREDAFCEITKRFIKALYSILDYMNDEEESCLFYVYDNNEMYNIKNFLSDLVSSQGKDLKSLESEEKEDVVKKATKCLVALFQDGTLLDVPTLEELPCLDKIEKNAMTERFVVIEQLLEQNVALPAQVYYEVSDAVKWMVDRKAVVYNFKKEWEKFSRNKTGNYEKEWITVLNLDKDNRTVNLRADLGSKTPDQRFRLYKIYEDKNENHPFKNMFEALDEATKKSIVDLLQDPNEWSMKDTFGDIDFNSPETKKSLNKFSLLCSQQEAVESIMKRRLQLIWGSVSLTYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAP1</accession>
    <name>A0A367KAP1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c oxidase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">COX1_2</name>
        <name evidence="14" type="ORF">CU097_012032</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the LAGLIDADG endonuclease family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000133">
        <property type="protein sequence ID" value="RCH99284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAP1"/>
    <dbReference type="STRING" id="86630.A0A367KAP1"/>
    <dbReference type="OrthoDB" id="5381460at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006314">
        <property type="term" value="P:intron homing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.210.10:FF:000027">
        <property type="entry name" value="Cytochrome c oxidase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0404">Intron homing</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016694226" evidence="12">
        <location>
            <begin position="31"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="651"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH99284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="714" mass="80286" checksum="C4E0FE94034182D3" modified="2018-11-07" version="1">MIGAPDMAFPRLNNISFWLLPPSLILLVASAFVENGAGTGWTVENGKQSPISNNRAIKHHSMRETPQLGENYSSNTNLLWTSNKLAVKMFSTRGQSAWGKLNYSTLSHQRLNVMQPKNKEFLQWLVGMTDGDGSFSVLRQNDKWTLTFKITQSTYNLRALYYIKQQLGVGSVSVESNRDQGSFRIRDRKQLANIIFPIFDQYPLLTTKYFNYAKFKQAYVILEDSKLTKSQRNAQIETLLLTKSDESYISPAWNKITLPIADANEASKVISKSWLIGFVEAEGSFYLVSKDANRIVHGFGITQKLDKVVLEGIRHILHISTKVVYKEKYNHYMIDTTNSRAISNVSKYFFNTIKGMKGVEYRIWSRSFNKHKGDYSQLVKVQKVLRELRKVEGIVRTIARAIEYNDRTPYPTDKGVASHSGGSVDLAIFSLHLSGISSMLGAMNFITTIINMRAPGMSFHKMPLFVWAVLITAVLLLLSLPVLAGGITMLLTDRNFNTSFYEPAGGGDPLLYQHLFWFFGHPEVYILIIPGFGIISHVVSTFCGKPIFGYLGMVYAMLSIGVLGFIVWSHHMYTVGLDVDTRAYFTAATMIIAVPTGIKIFSWLATLYGGSIRFTTPMLFALGFLALFTIGGLTGVMLANASMDVALHDTYYVVAHFHYVLSMGAIFALFAGFYYWIGKITGKTYNELLGQIHFWSLFIGVNLTFFPQHMLGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB86</accession>
    <name>A0A367KB86_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000126">
        <property type="protein sequence ID" value="RCH99400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB86"/>
    <dbReference type="OrthoDB" id="2206027at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="69" mass="8124" checksum="71CF193AA7FE512D" modified="2018-11-07" version="1">MDGTFDYLHWEKSSLPIIADLWENTPKSEELIDIPVTANVEETIELQLNEKENNKPYVKVEWKPNPMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBE4</accession>
    <name>A0A367KBE4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PI-PLC Y-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000142">
        <property type="protein sequence ID" value="RCH99161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBE4"/>
    <dbReference type="STRING" id="86630.A0A367KBE4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="5">
        <location>
            <begin position="657"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="800" mass="89967" checksum="7056FD261E6E9751" modified="2018-11-07" version="1">MTNIMDKTNKKGRSTFQDPNKIDKAGRTKIFYYTSSGSLDKVKELVERGANVNHKDHAGWTPLHEAAIKGQYDAAKYLIEQGAIVNARGFEDDTPLHDACSYGFVDCVQLLVDSGANVYALNSEKQTPLDVCEDEDCIRILKAKMKEVDEIVSIDDQGQTILHRACTDGSFEKVKELLSIGANVNARDSSQSTPLHCAARHGHLSLVDLLIKNGADINSVDHHHSTALHLASQHSHQAIVQYLINSGADVHIQDENNLTAYQVSDSVVIRQIITAHIDQENRLRATTEAIDEITFVSNTKHKRIKEDTVLSREERKIQAIMKSFEKAEKSQQLKKTKKDKSSTTTTTTTPPPTFPSKKRKMTSKQASRECSVDDDTPKKKPMVDLVKLDKKDNLGYTQLHKFAMRGYVEAVEQLLKAGANSCERDNAGYTPLHEAALRGKTDIVRLLLEYNADVNSRGADLDTPLHDAAENGHTEVVQLLLEYGADVTIANSKGQTPLDIAIERDDSIADILRQHKPTKPKRRRLVLAANMACKQPESPVSPTSFELKTEISVKDAKAHARQLSGQHLPKKSLKNLQIVKTEMPVDGYQPLIPTPPPDHWTKVIKKEEEMMGLYDDNKTHYPSIHCASKFLPLYTIQQTEGEHSSSFYVTDIQVGLLLGVSTEQLLRQYPHLSRRKASDKEKERLWSPLSPMICFNVSINEDKALDCSSKTKEIEKQRFLKQDLYFVRLDQVVSIIKNDYSHLSEILITITLDIGYNSTTANEMDINRKMNTIKLPPKFAMKMQKCRMLKFDNSKNNHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCF0</accession>
    <name>A0A367KCF0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000095">
        <property type="protein sequence ID" value="RCH99857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCF0"/>
    <dbReference type="STRING" id="86630.A0A367KCF0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="825" mass="94148" checksum="7E01A0F4C0998687" modified="2018-11-07" version="1">MQTSKEDTKLNKEQENIDDDEEEDIAFFRQHHSRKLKRISCSSSPEPFEQQQQQQQQRQQKKGRKKSISNPNKTDKAGRTKLFYATSQGHLSRVKELVENGANVNFRDNAGWTPLHEAALKGQYEVGKYLIECGADVNARGFGQDTPLHDASSNGRADCVQLLVNHGADVFALNESKQRPIDVCEDKECQSILRAKMKQLDRLLARDKDGKSLLHYACINNKIERARHMLEQGADVNAKDNHDWTPLHLACLHGHLDIVKLLIQQGAVVNMLGSEDMDTPLHQASKHGHKEIVLYLIKSSNADVNIKNKYDQNPYDVSVSFPLIRQILTARMDEVRLEKEACNALDEIASRTASRNEPERQLMTREQRKIQHVMRVFANLEGDGKRSSSDDRSCTKRKRRRKSVSVESEDTSVITSTGSSSGHRKKPSTGTSLDPFKKDTTGRTNLHKYALRGNNEMVQTLLDLGADPNEKDYAGWTPLHEAALRGQIDVIKLLIKHGADVNARGGEELDTPLHDATENNHCDVVELLLENGANPFAKNASNLEPLDIAIEKDFEDIIVALQAVSPVYRKRKSQRKPIVKTEEEDDDDDDDEKHSEVKHVNQRRYAIDNADESDEPAIKRPKKRRRLIQAADLEKSSQYSRPKEKVRVKIEEEEEGESDKWPCISNKKRYTDDAKRTDSRSPIPTPPPEPWLKQREDSQRYSLLYSIQLSRNDFYVIDLQMCLFLGIGTTKKFWNTHPELPKLSVTLEQKRKLWQSFKPLLTGEDLDTFLARELYFIDFDDAMNIIKSDQNCAAQNVVTVTLDINPAQHKRLPPKVLWKTKYGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCM0</accession>
    <name>A0A367KCM0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000087">
        <property type="protein sequence ID" value="RCH99992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCM0"/>
    <dbReference type="STRING" id="86630.A0A367KCM0"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="209" mass="24016" checksum="38C999C5025839CF" modified="2018-11-07" version="1" fragment="single">AGKVTAETFDHETKEYQVAYTVKHQPSNAYRTRKRQDSIWCTDIRFYRDMFPHGVDIRVIPEHSTRSEVLMDHCTIKVFTIDESMDSKQVTLILKPLLDDAFDCTMYRYNNVLSQPPVKQLDKKEEKEEQKEELKAPDSSAEQVSTDALAAPDDSIKVPKGYLLISEHQNNNIIVISDELSFNSQQISVIFIAMVLCYYMGKFTSCNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCN7</accession>
    <name>A0A367KCN7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000090">
        <property type="protein sequence ID" value="RCH99936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCN7"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35735" checksum="EEB2635004BCBD13" modified="2018-11-07" version="1">MSSLVVYGDSYSDLHAESKRTNGPVWSQVLAEQWNAKLISFARSGARICPSSNPKSSWLKKQVDESLLSIEKGSIHAIFLGTTDLVVAKGNTQSRNKEWIGCIEDQVTAILEKDPEARILILGAPALEFSPFGQKHKDQLKDNIMSFKVDLEEKVEEWKGQDKNIEFYDTYLMFSNLLGDPSEAKITNVDDAYWDKCQGQCNDEMNQYLWWDSLHMTGAGHIAMAKEIASFDFFGIKASEPISILTEAEDTVDNNSHNGSNLSQNYIQCLSWLLLGCVFMMIIYSFRHSRFITSLKSKLHSKTSRLYRNKDYTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDG2</accession>
    <name>A0A367KDG2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MIA40_2</name>
        <name evidence="20" type="ORF">CU097_013333</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000094">
        <property type="protein sequence ID" value="RCH99871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDG2"/>
    <dbReference type="STRING" id="86630.A0A367KDG2"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="19">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH99871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17078" checksum="D869B50A1E017ABF" modified="2018-11-07" version="1">MSTVVEGKDTVKFVTEEEIDNAATVVEEKQEEADSQSAAFNPETGEINWDCPCLGGMAQGPCGEDFKAAFSCFVFSEAEPKGLDCVEKFKAMQDCFRRHPDVYGDEIDDDDEEEEETAKQAEEIKESTQDASIVASSPDEEQSITFSSWVSSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDL3</accession>
    <name>A0A367KDL3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone transcription regulator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HIR3_2</name>
        <name evidence="4" type="ORF">CU097_011558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000072">
        <property type="protein sequence ID" value="RCI00231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KDL3"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1547" mass="178101" checksum="B520CC8B03CFBDD7" modified="2018-11-07" version="1">MNSWCTINKGVVVSKKAESGAQVEELVAIYEEALRLQQKGHMDEAKTKYEELIDHKYLKKEAKNMKNTNNNKNNEDQNSLVSALFYVVSKNYAAVLEDEYIKNNNIDSAKDALKYYLQAVEIDPTDHSVWYSIGQLSRRLKNLRFARLAYEKGMLANSTGKSVLDTIRDQLTPIQWKCLEGICTVLYDIGDFYTCRYYVEGALKYYPKWESGELLLENMNSEHMMESMDMENDQEDATPIHVKIERPDLSVLMEKLFAVYKKQSTANNLEEEIEDESLERDIDIGNTSFVNAAIKITIDKRDDDFRSIPTREEAIVPSSVSNPISAPVIQLVNTEEGVSNGIAINPQKRNREDDAIVVEDEDSEQEDKKPSLRTSRRKKEKLLNNETSRLKMLEEEKEFNAKMQRFYDSLKDIPSLYRDNPWFEPQQSVISVQPSFWDWFDIKISELDSTYCWDMDGKKGDLDSLESNSKGKGLTLFSLNHTKSGSHEQQFIHFVKETIHRLNENNSGIVDTLCRLVSAVVKNDMDLDNDTPFLSNNLLELITDIITALDMNFINCMICVDDDEKALMTLRICEYFIDRLIRTIMVATHETSPHVGFSTNYKKKMSNLLSKQSKVKQIENLMEATKVWVDLLQRVLFNLSAQWIQSNVKTETPEENTILSDDEQKVLLRYWIIHGKLAQCQDDIQSAYDFYEKCKRLLKANASLTTMNIKSMYDSFIDLNSIENKLSLLQVGKLVIQAKEKSDIGDFSTVIEVIKPMIKSNLDIDDPIGSDETIQMTLLLAKAYVQAKQHVEAWNSYKQVFVALINQLVAYGFRQFQSKSILCKDEDTLFFKMGKHLAEVMDELVMLLQHPKSDEWLINVVDKDFMDGLSVLKRMTLFYIFRHPDFVPLVNNFSSPDSIPHTPSRTTKSNKFNSIVVKSWVISSHIIKQVLASQVQDTYSIKFSWVKLLQELHDELGEREICCVANNAFLHHLLDCLIETDGQAFRKDIYQCYHCIYGVHLGGESDLIEEHYCTHINMDQKAAERLFNLVADAAVKRLKSGSLLKGDLKEVVEAVSDLFEELPKVDNQSPLHFNRTIIKNHLNRDISLSSSISSLYRKTLIPTVPIDGKKHNISHVYYKIFWIRGKTLRIQIKNRPKIASEKNMVDLETAIDEFTSHLVLNSDDSNAWYDLGACYHQLADEELHWSATNVNSHKNLIAEYQKKALHSLLRAIYLGGLALNSSQKHELFMQLGDLLYSMASPPMDMLALKPEEVNNYLDAEGALVSVKKETPHRKAAYKLSLAMYIHAFKNKIPQKQQWPCYYAIGKCFAKIDRPPKEVLDWFIHAIRLGGHNEGSKEGPLEPVYSLCSYLTKYLYQQKISTSLVMEYLRMEANIRAAQMTNGPPEELGMNTFHINSVENHGLIESAAGYMPLDVASAYSAILKRLVDITHADTKNWHHRPVYRIAWIHYYIFRNPDKAKSELVKLFTLKPTIKNHINIWKPTSELPGKHYVYIHKYTMFLIKLAKETRDESTLDQLNRKLRKAQSLLLNYEQVMNEISHIEKSEQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDU6</accession>
    <name>A0A367KDU6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000064">
        <property type="protein sequence ID" value="RCI00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDU6"/>
    <dbReference type="STRING" id="86630.A0A367KDU6"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="189" mass="21549" checksum="12F69625B94C2FE5" modified="2018-11-07" version="1" fragment="single">MLISPPVVTRRDIPPGFIDFASSSFDAIFYSNTIDSTPETTTKTTTTTTGEIQKRSTHLPDLIPFISLITEKCDVQPVHLVMALMYVQRFRRCLPAGYKAEPEAAHRIFVASLLIASKYSEDRCLSTKQVVRATGDVWSIKEITRMELAFLRFLHWDLYISYEEMVRFLKGLNFDVNTILPSVSLDDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KED2</accession>
    <name>A0A367KED2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000052">
        <property type="protein sequence ID" value="RCI00575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KED2"/>
    <dbReference type="STRING" id="86630.A0A367KED2"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="424" mass="47595" checksum="7DC4E592C99C3E9D" modified="2018-11-07" version="1">MARHHKHHSQNHHHHSHENHKEETVTQEEKEPQIIGLVEQEMNIPNKKPSSNTATGFVSRVSSIPVVQDSLSTVQAIASKTSLGRLALSTANNTFTTVSKYTSQPKYVQTYYESYIQPQIEKADAFGCRSLDFIETKFPVVSQPTEDIVRAVTAPSYQIVDGVKVRIDSIKQPAHQVAKEANKRFGSVVDNVEAVINRYLPPAEAKQQDRTIDEANQAVRAYYLLNEATLRLTQRVQDQVKTTTAQIPRSPSDLARIAETSALIQKATLNIQSLQETLAVYAQAAQQRLPPAVTERVLVLHATTQERIQGLTQQVSTQLQQVMGYIKVQSSETPEWLRSRISSLVDIANKQVELVRNEYSRKDINSFDKARNVAQGFQSQVLPVLETIQAQLNHYTEVARQKASTKFPFDYLGLNHAPKLAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KES2</accession>
    <name>A0A367KES2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coth-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000049">
        <property type="protein sequence ID" value="RCI00631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KES2"/>
    <dbReference type="STRING" id="86630.A0A367KES2"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562060" description="Coth-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65720" checksum="C2782CC2DE21C17B" modified="2018-11-07" version="1">MLLSNILSTSIGFLLAVGVAAQQDQDYKVDYNVISLLNQTTFKSMAVVIDNISYPLEVNKTFPILYSGKGPSAQTGYHYAKVYNNDSLLLEPFVRQPVNQSTPHEFFNRSWNTHESKQLPQVYPPLDAIHRIHSDLHRDNEIPTIHITGNQTLIDQMNRNTSADISVPSNISYLSLRDAFHFEDVEISLSGRSSRWMPKLSYNLKLKKKDDLYGYRRLKLRALYTDPSYIREKLAYDIIKSVGLVSSEFSYVRVLMNDQELGLFGIIDTFKNPWLANVFANGSSSYKNGYLYQGVFSTPESSAQNHTSDLSYMNNITAYGDGQYKIKEEASKGKKENWEPLMKFTEFIAKAPTNSSDAVHKWNKELDTDSFLRSMALEVLLGYSDGYLTMADNYYLYQNPETDNFFYISSDMDLTIGSTMFKLDKMWSGNYSNFPQVYSRPVMKQILQVPEFKEKYNQLLQNITSELINPNVTAPFIDNIVDMIKEDVAWDQSLPRTGNNLFAGSFGNVQNNSEVTDVIGQLPPGFDMDTLVDFAKRMNETIPLETAVNGPTGHASLTGIKEWFNAVYQNTTRFYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFH9</accession>
    <name>A0A367KFH9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_015665</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="PJQL01000036">
        <property type="protein sequence ID" value="RCI00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFH9"/>
    <dbReference type="STRING" id="86630.A0A367KFH9"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="148"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="834" mass="93674" checksum="D588F9220DEB2CD5" modified="2018-11-07" version="1">MALSTEDTTNERTPLISQATATQRESLKRTYHVYGITLGFLFFFSFFVHWYRSTLPTPLSDVQANNADDFAGIHAYNEYLSHFTAPHSGNTRENGVMRDWIGSVALEFQKEATELGLKMDVIANDTSRDIIPSNWFTENEHWFIESRNVIVRLHGQSGRDKALLINAHYDSVPTSHGVTDNGMGVATTLELIRYFIHHPPQHTIIFLFNNLEEGGLIGAQSFIRHPWYSSVKLFVNLEGAGAGGRAVLFRCSNLNAVKKLANSKTSLVHASPAGNDMFKANLIKSDTDYSVFTKEGTPGLDIAFYAPRSHYHTPRDDLAHTTPGALQHMGQLALGAVRSIANSDDMLDTPSENQSFVYFDILGRFMFAYSLTTLQIINGLVLFLVPALGIYLSVSSKRENESFVDVMKEQTYLAAQGLAACLLAFVFSIIFIGVASFLLCYINPLMTYGDVYGAALYIFFTAFLGLQVSQLVLPAKMKHTLATTDASWHGLVAFWWIFLVVAIFAASKSVVSLYFVVFLVFFTTAAAVIQVILPQDKKFRSPVIFFTQTLVPFVFLLELEFMSMDAMRHATVDGTPEIAVYILISLPIILTIMHFVPWVYVAGNNRRATIIAAAVFLFLFTICSALDPFNGGWSPNKLVFKQEYNAGEAFAMVNITTATGIPAILKQALPRHEYETINCTTSNTLTTCRYQTELVPKYASNETLNEFALYDVQKTCHDELCQVTGTYRAKNSLMCRVLFDRTLEHAWIDNMKVQHKKIGALIAYVNQYEQRVQFGYEYSKNDVKPNATFSCFYDEWTQQEIPAFTTLRDRLPEEALLLIRGQGLVISYFDKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGA8</accession>
    <name>A0A367KGA8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000036">
        <property type="protein sequence ID" value="RCI00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGA8"/>
    <dbReference type="OrthoDB" id="2292140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="102" mass="11680" checksum="134F52D8B879E548" modified="2018-11-07" version="1">MQCDMRTCSRIDYQTEINMNSKLFIVLFAAIFTAVSAMTCKCARGPTVLTRKVCQELSFKVGTDSKHTDFGRTTCYNMTKDNTTKYFIPQCKKDGGDRWVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGM7</accession>
    <name>A0A367KGM7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000015">
        <property type="protein sequence ID" value="RCI01319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGM7"/>
    <dbReference type="OrthoDB" id="2281761at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="85" mass="9852" checksum="F0E1F3949F8F8D55" modified="2018-11-07" version="1">MKAIIDQQIGLGIDHPVCYGLLVEGYDCYLYKKSIQYETEYRSILIAQFRALQDVLDIMLLLPAINVLTHLDVIMYISFHKLMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH64</accession>
    <name>A0A367KH64_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">mRNA decay activator protein zfp36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZFP36_2</name>
        <name evidence="8" type="ORF">CU097_015615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000021">
        <property type="protein sequence ID" value="RCI01192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH64"/>
    <dbReference type="STRING" id="86630.A0A367KH64"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI01192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="348" mass="39933" checksum="AAD3306AB5D5F806" modified="2018-11-07" version="1">MSSFPLTNSMDLTSRSSFEFENCMDKSIKSSPMMNDLNTCFSEEEESDSTNSTNSLENNHKRFNKAVLKKREVKLNKKDELDSDNDSLIEYSKNTKKTKNTKKQQSSETEKKQKSLYKTELCRNWEETGQCRYGLKCQYAHGAQDLREIERHPKYKTQKCRTFHKTGACPYGSRCTFRHFSLPGDDAKIKEENDKMGSVTGTSATTTTSTLSTTVFRGTESSKREPMVFPSAFTENLKMFQPNQWYNDASFPFATTATTIPPTLGDQPLKRNYSPFVDYEDSLLPSNAESLLPHQLLFDLDSPDVEEQMKHCPLRNYVSQIPSYQHTTINTTNTNDTLCKSLFRPWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJH1</accession>
    <name>A0A367IJH1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator of nonfermentable carbon utilization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ERT1_1</name>
        <name evidence="3" type="ORF">CU097_001226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005758">
        <property type="protein sequence ID" value="RCH77671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJH1"/>
    <dbReference type="STRING" id="86630.A0A367IJH1"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH77671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="12544" checksum="E449DA969E0E695A" modified="2018-11-07" version="1" fragment="single">SVLLYPASRKTQFPNVKKPYNYVEGYHYLINYVREKMGKQELMRISKALALFRPSMIASMMNLTEADLIFTERCLQRTMMEYEKLVPYSGTPTVIWRRTGEIVLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKZ6</accession>
    <name>A0A367IKZ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005243">
        <property type="protein sequence ID" value="RCH78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKZ6"/>
    <dbReference type="OrthoDB" id="2276207at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="71" mass="7787" checksum="B9A75EDBE83B3016" modified="2018-11-07" version="1" fragment="single">LKFGNIGTVLLASVSHQTRQTLGQASCLVLGYKPNDPEERKKAKEHLEKSGLIAVHIRNHDPFQPTAIGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL99</accession>
    <name>A0A367IL99_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005150">
        <property type="protein sequence ID" value="RCH78462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL99"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8397" checksum="2E21EB51A22C3A32" modified="2018-11-07" version="1" fragment="single">ASTDMVVVRAEAEAKVTAVVRVMVKATTRAMARAMARTTARARARATRVFTSNMMTRKMTSSSITMSTLLKLLWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMP1</accession>
    <name>A0A367IMP1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004932">
        <property type="protein sequence ID" value="RCH78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMP1"/>
    <dbReference type="OrthoDB" id="2280379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9651" checksum="4D15BCFC4301DBD4" modified="2018-11-07" version="1" fragment="single">RTYVDNLRKEVFPEKEVSKGGRPAKLSAEDKRACVRMSTVGGLDNAVQVANQLNQRVGVRVSPKTVYRTLKAAGLSAVAKVKKPRIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INL3</accession>
    <name>A0A367INL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004601">
        <property type="protein sequence ID" value="RCH79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INL3"/>
    <dbReference type="STRING" id="86630.A0A367INL3"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="227" mass="24394" checksum="07CE471514FB787C" modified="2018-11-07" version="1" fragment="single">MPSGKNTDAIFMPSFCFGEITRAEINSVLSIAGVPLTPPKKTPFVTGIPPRKKPSEEKKIEPIKEEESVKKPPITNGTNSPVETPKPKPKSTATSWAALLKTSENKLKASSASSSTSTTASTSVPNNAPTVNGKQTPKTSTSPTPPITPKFTGIADIISKYEPTFNAPLLQPRGLINNVNTCFMNVILQPLSHCPPFYNLIKTISTQVAHNIKSKTPLLDSIIEFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPN5</accession>
    <name>A0A367IPN5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MET8_1</name>
        <name evidence="8" type="ORF">CU097_002234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01004387">
        <property type="protein sequence ID" value="RCH79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPN5"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="7">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="14489" checksum="585761FE7A979385" modified="2018-11-07" version="1">MNLFKGGGSLIVTYQIANKKVIFVGGGNIAAQRIVLLKMEGVHVTVVCPESGLAEEVDWINRKFINQDLDHADICLTALDVHEESLRIGQLCRERCIPVNVADVPPLCDFYFMSQHRDGPLQLAVSTNGQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQ67</accession>
    <name>A0A367IQ67_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CTA4</name>
        <name evidence="9" type="ORF">CU097_001026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004276">
        <property type="protein sequence ID" value="RCH79802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQ67"/>
    <dbReference type="STRING" id="86630.A0A367IQ67"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH79802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="300" mass="33792" checksum="D49ADAC8D5CD9969" modified="2018-11-07" version="1" fragment="single">QIAQQQNQNLTPAQRRQMEQKRKIEEATQRMMEGMDMEEPPTIKFGDASVAAPFTSKLRNVTSINNIIRQGRCTLVATIQMYKILALNCLISAYSLSVLYLDGIKFGDYQHTISGMLMAVCFLCISRGKPLDKLSKERPQPNIFNPYIILSVLGQFAIHIASLVYINALAKSLEPQKEVDLEGDFEPSLLNSAIYLIQLSMQVSTFAINYQGHPFRERIQDNKALYYGLMSVGGVALAGATELWPEVNEQLQLVKFPGSFRYKLTLCMVLDFGIAYAIEIVTKHLFADNKAKAIARRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT87</accession>
    <name>A0A367IT87_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003784">
        <property type="protein sequence ID" value="RCH80691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT87"/>
    <dbReference type="STRING" id="86630.A0A367IT87"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="298" mass="34237" checksum="DAE10D453B690D15" modified="2018-11-07" version="1" fragment="single">LPTMIVIRIVRKPPVAHEDYIQITTSRRTKRTVSQLEEEDRDKHRDEEGEANKKLKMSIDFICNHESNSKSDDTTHLNLLVNAAVMETKYLPEKNQDELTIVVNPDLYPSHDSPPLSTKADSAVSLSPKTEKKEFDDFDYLDPFLDDVSDLSSVSSSVFDEEEEELQRQKNDSIKKAKKEKDLTCIACKRPLQDIPQQVGAETHELATWTWSPSAVFTDWCPKRCPRCERHFIIFRQEWPNRKQKKTAKKSKRKKLNKKIIDLPPAMDLLSSQLNTPSELTPSSEYAPSPSLAEEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITC1</accession>
    <name>A0A367ITC1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma secretase complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">APH-1</name>
        <name evidence="8" type="ORF">CU097_001982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003657">
        <property type="protein sequence ID" value="RCH80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITC1"/>
    <dbReference type="STRING" id="86630.A0A367ITC1"/>
    <dbReference type="OrthoDB" id="6507463at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="201" mass="22722" checksum="B8E96CE5941A11D3" modified="2018-11-07" version="1">MSLLSFFGCLFLAYGPILSIFILFIAPTAQYVLLTVASAFFCLIALLLSSVIWYASRTNYYISILYSIIIQELCRYCFYLLQRRAEHGLNSISANPMFPFNKHIFSFVFGYGYALTSALVGYISLLVESIGPGVLMCVSCPQTTLYFISAITTSLFSLLHIGWMMISFEGYSELPKPRGYCKILWVILSHYGASFAVRYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU25</accession>
    <name>A0A367IU25_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01003541">
        <property type="protein sequence ID" value="RCH81193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU25"/>
    <dbReference type="STRING" id="86630.A0A367IU25"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH81193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="255" mass="29762" checksum="37EB841E80E8DECC" modified="2018-11-07" version="1">MDWLAHSKKKHCELCNHTFKFTPVYKNDMPSTIPTIYLIHHLAYVIYTAFYYLIRVILALFVWLGLVPYIAFWSWQLSAWSAMGSQRLLSRILLQPVSDIPKQTKYNWNWETILYDCMKGWMIEFGFVLLLILGLLLHEWFEQNVPFVDDIEWDHPRPAMIEDDLLNEIDNNNNNNNGNNHFMDNNNNNIANEEDIVAGVDDFNGLLQGIGIRGNILNLFQNASLITLLLCFSIGIGVWIPYIIGVLFIMVRYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUC1</accession>
    <name>A0A367IUC1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uri1, prefoldin-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">URI1_1</name>
        <name evidence="6" type="ORF">CU097_001832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003592">
        <property type="protein sequence ID" value="RCH81081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUC1"/>
    <dbReference type="STRING" id="86630.A0A367IUC1"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="5">
        <location>
            <begin position="549"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="643" mass="74861" checksum="D8416705E197B1B6" modified="2018-11-07" version="1">MTDQISLFNDRLSQQLASLQEEYQRWNNYKTDYDALESLLKTLPDNTTRSAMIPLGKVAFMPGKLVHTNEILVLLGDKYYAERSAKQAIDILSRRREYVQENLNLVEAQLNSLKAKSNSILESGILAENQERLPIMEIKEEWPEDVKEEKENRKGALVKVSSTELPPSVQRARDLMKQSVKEKSTDENKALFDMLDELEEEEEGENEEEHVDSKGKPWLKKLNEDSDQEEENEENDDDRYDMEISESIFDRLNEENDEEYPLDGIVDQDDFTYYDQETVEDDTYERSTPKLITKPKNKKSEEKKPESKAQPMQQHVAETTQDDLTIIPKQLKDEEEKPKNEKKKISKFKLMKQQEQSKGKTKEETRVEKMPTEKIPEEQTSKDKPKKVSKFKSMKQQERGEEKEGKPKKVSWGANTTVIEHENYDAPSVISQTSSYSEPVKNEKDATIMIRSPADIFKVIRQTQEDGYPSLDDDDNGQERTSDPIDLNELIEAAREKREPYYRTTDTTMIHIPRQINHSDDDDDEEEEEQGSIIVANKSKLDNKIMKGSVMERDTAPVDMEKLEDDMDLREITSKYHQKRQQLLAATGGFSFEPKPEIEVFEEELPLPREEKEEEKEEEQVVPKKMSRFKAARLGLVKEEHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVA4</accession>
    <name>A0A367IVA4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ATG15_1</name>
        <name evidence="18" type="ORF">CU097_001066</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01003385">
        <property type="protein sequence ID" value="RCH81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVA4"/>
    <dbReference type="STRING" id="86630.A0A367IVA4"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26363">
        <property type="entry name" value="Phospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="219" mass="24249" checksum="9E33C9978A267F93" modified="2018-11-07" version="1" fragment="single">CLQKKISDSELYYDNALALYSEVANTYPNSTIWITGHSLGGALSSLVGQTYGVPTVTFEAPGDRLASSRLHLPQGRGVKLPIWHFGHTADPIFVGVCTGPSSSCWYGGYAMESRCHTSKVCVWDTVKDNGWRVDIRSHRIKDMIEAILMKPDEFSMPECVEEQDCEDCGLWQYYDERDGPFPITTTTSTASKVTSTSTIATSSEPLGDPWKTFNDINTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVI8</accession>
    <name>A0A367IVI8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin mvp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MVP1_4</name>
        <name evidence="3" type="ORF">CU097_004600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003316">
        <property type="protein sequence ID" value="RCH81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVI8"/>
    <dbReference type="STRING" id="86630.A0A367IVI8"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="353"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="509" mass="58655" checksum="95D9FC9205DDB964" modified="2018-11-07" version="1">MSESSKLHPFFQPRRPKPTHAEEPIIDTSRRQTRQTTLLLAQKQQDLKEKESTISEEKVEKKKPFVITKRPPATVPKLLSEEPLESQCSNPLLRPYEQSTALSKEQEFDFYGPIKSKKTVRGRFDHEFARLDRSIYKHAHWPPIRRDDAIELTRVHQVTNANHIKQLIKSTPCFQSKKRQPKQSSYKTTKQKKIHGERELRAWLDRHYPEWHTFPSCTRLVRMILGPSVKSNQSWIDKYRPRTVDGLVGAKHNHVYLKNWLHQMKIEPATAPYRDEGNIKKHTKKKKKEMDDDLLLDGLSLNENQTNAFDRLMKKKKENDDSSDDDFVVSPAAVRKKAARQQHQGETVRSNMVLLVGYHGVGKTALVHTAAEQEGYEIFEINSGSRRSGKDVVSAVGEMTKSHLVTFQNNVPEEPQKKRRLNPFLSSKGMTNTAQGKGQLLNFVRKSNNGNNNNKKFNLNRSADGPKQSLILLEEVDLLFEEDKGFWTAVVELSQKSKRPIIMTCNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW67</accession>
    <name>A0A367IW67_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01003315">
        <property type="protein sequence ID" value="RCH81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW67"/>
    <dbReference type="STRING" id="86630.A0A367IW67"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="187" mass="21354" checksum="3489EA98DBDC85EC" modified="2018-11-07" version="1" fragment="single">LEFDRLPGGKPYLKHHDNIDFNISHEGYWVIFGCVKDMNIGVDVVVVDSSNNSLDEFMHAFESQLTIDEMSLIANSKYDKLSTFYEIWGCKESYIKAIGVGLALELDQLNFRNENDMIKLYLKGKRLDSWSFYMTYIDPCTIAVVCCGRNDSSIVNFHNVNTKLIGEPIPSNQANLFHQCQLNTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXB0</accession>
    <name>A0A367IXB0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003060">
        <property type="protein sequence ID" value="RCH82318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXB0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="9060" checksum="C8A84BFFFB7BE8F1" modified="2018-11-07" version="1">MAIRTREQIPNVKHDRQNLVLILDKNALVDDDEVKEKWRLPTSGSVVLSKFMFGMINALGTNEFPALLLTFGNNTSPLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYZ0</accession>
    <name>A0A367IYZ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002852">
        <property type="protein sequence ID" value="RCH82903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYZ0"/>
    <dbReference type="STRING" id="86630.A0A367IYZ0"/>
    <dbReference type="OrthoDB" id="2289193at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="83" mass="9474" checksum="C4DE4A789BC33C8C" modified="2018-11-07" version="1" fragment="single">SQSKPNSEHKAYLVDFFDKNLSAVIQGAAENWTKSFEGLEIKKSRVTEFMKEECNLSIKVVTRHPVVRNSNATLEARAQYVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J072</accession>
    <name>A0A367J072_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002696">
        <property type="protein sequence ID" value="RCH83338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J072"/>
    <dbReference type="STRING" id="86630.A0A367J072"/>
    <dbReference type="OrthoDB" id="10342635at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20848" checksum="9F2242313D78D6BD" modified="2018-11-07" version="1">MSSPVGIFDSLDELLTITMGPNESVEQYVYRFKILSYFSDVKEPVALFVCFMAGLSADLHRAVSLDLLMASEGERYSVDYAISLAEKTNNKAFSSSCSVKKRRFIPCAVPDRSQPYKKPSNNRYCSFHKNHSHSDAQCCTFKKSKITGDKLPSPSSGMTRSSWDPSDTGARWSRYANNTQAAKPWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J276</accession>
    <name>A0A367J276_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_005460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002509">
        <property type="protein sequence ID" value="RCH83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J276"/>
    <dbReference type="STRING" id="86630.A0A367J276"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="186" mass="20950" checksum="96764A0CC07E4B0D" modified="2018-11-07" version="1">MKDIYKHDELEIPEGVKVNIKSRVITVEGPRGTLTKNLRHLAIEITIVGKKIKFVVHHGLRKHVACIRTVRSLVNNMIIGVTKGFQYKMRYVYAHFPINVIISDAGDAVEIRNFLGQKVAFHVKMREGVKVEASKAQKDELLLTGNSLEAVSQSAADIQQSCLVKNKDIRKFLDGIYVSERNVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2I4</accession>
    <name>A0A367J2I4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenyl-nucleotide exchange factor sse1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SSE1</name>
        <name evidence="7" type="ORF">CU097_006169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002511">
        <property type="protein sequence ID" value="RCH83931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2I4"/>
    <dbReference type="STRING" id="86630.A0A367J2I4"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="724"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="773" mass="86362" checksum="B55813B25203C9E8" modified="2018-11-07" version="1">MSVVGIDLGNLQAVIAVARNRGIDVICNEVSNRATPSIVSFGPKQRYLGEGAKTQEISNAKNTVISLKRLIGRTFNDPEVQEIEKNHLMAELADANGQAGVKVNYLGEEAVFSNVQLLAMYLHKLKDITSAELKGPVSDCVITVPGWFTEVQRRAVLSAAEMVGLNCLCLVNDLTAAALGYGITKLDLPEDKPRNVAFVDIGHSSYSVSIVSFLKGQLTVRGNAYDTHFGGREFDAVIVDHLAEQFKEKYKIDVYSNKKALLRLRVAAERCKKVLSANPQAPVNIESIMDDKDVNAMVDREEFEQWASHLFSRTESVLAKALENAGMTTDDIHSVEIVGGTTRIPAIKATISKFFGKDVSTTLNQDEAMARGAALQCAMLSPVFKVRDFRVNDICSYPIKLTWDATPEEEDTEIVVFDNNNSIPSTKILTFYRREPFTLQAVYANPEALPRGINPWIGQFNIKNVQPVNGEPAQIKVKVRLNIHGILTVESAYTVEEKMVDEETKNKDGEKEVKKVKKLVKTGDLPVISGNTSISKELINEYTEKESQMYANDKLIAATEAAKNSLEEYGYEMRDKILGPLSEYIDPSIKDKFADDLNAVVDWIYDEGYDAPKSVYVEKLEALKKIGNPVVERYREAEERPHAERSLRETIQRLTQEAMSTDEKYSHIPAHEKQDIVERCERAGRWMDEQNAKQAQLPKFETPVLFSRDIKKEEEAIIYFANPILNKPKPAPKVEEPAANEENKSENTTPAADADTPMEEASDNKKKDEMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J366</accession>
    <name>A0A367J366_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002381">
        <property type="protein sequence ID" value="RCH84382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J366"/>
    <dbReference type="STRING" id="86630.A0A367J366"/>
    <dbReference type="OrthoDB" id="2275777at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="45371" checksum="C81E252FC0E7E02F" modified="2018-11-07" version="1">MRVMKMAVKQRKVLSSLKGKEALDFVPRHPHSFSHGAPSISKPAAQFPSIPSTSKGKGKELSLHRPSSSTMNKLPASNPASEVSAVTSAAPNKPTATSTMAPMSKVEDEEPEEGEIVDPSPPHKTQQACSKHDNKPSCFKPNEAYDNESLSGSMAKGIPANSTAAPTKGVLSTTAPNANTMEQCKIFTIMFRNLAHPYKQRGDGEQDDLVSALNHLHALCNYIISYFYKEKQNPDMAPPESVAAWKSLLPLGDMLLAKLQAQEQYLLYGICLRLMAMVRFRIFNKMQGEVRSVLVRHLQAPSVSGNHQYIKISCGLLEEYEQVMAMSASSEKYFNYGIMASKLPSTFKQVYVDGNLLSGITIGGKAGVQVSPMFPFHLNASLLHGAICTKCILSEFVSSMELDFKLIDDTDDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3C6</accession>
    <name>A0A367J3C6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01002370">
        <property type="protein sequence ID" value="RCH84425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3C6"/>
    <dbReference type="STRING" id="86630.A0A367J3C6"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25658" checksum="76A06DA5747EE328" modified="2018-11-07" version="1" fragment="single">MALPLSSSARLNDSKRLQYQFKQHAGRFLLVEFTDEELNSIIPSPYPLQNNPIYNRIFKVLKSGLLLAGRQYKFLYTSTDGLRNHSCWFVAPTDDLNRDEIIYWMGGLDEIKSVPRHITSVGQVMARRLTSLEISKNEREKIDSYEQHGFIFAKECGRMSSAVTCEIRRSLELKYTPSVIKLNLASGKNILMLSNYLSKRKVQFRSGQIHFNTDRKGCYHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J431</accession>
    <name>A0A367J431_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002291">
        <property type="protein sequence ID" value="RCH84702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J431"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="243" mass="28029" checksum="A6FA6F0D5EC7C037" modified="2018-11-07" version="1">MENSKINYLRDNLSNFRFDLYLAQYRFRNRQYAEEEFTRLIRKILTFSICETGQELIDFAKKIDSEHYEIFTRAAVIDYWEAVAKEIIESNQRSALLDERVASSSSRTIASANGNLRGKRRANNQLEPSTADAERLNEVFNEVSGIPFTTLTNRLIKNNCMDLSNDSDGSVLFYLPTEKAVALKEKYLKNPKLIKLDHGAIKVVRSLLKKKNQVGDLKTTLLFLEQAFKSPNNSQIFMVFHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4I0</accession>
    <name>A0A367J4I0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002244">
        <property type="protein sequence ID" value="RCH84874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4I0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="8219" checksum="E82F58671D777D14" modified="2018-11-07" version="1" fragment="single">MKSSLMQEVAHEEGERVQKKLKASVAISSNDDCSVMSGSNVEEDETESRKNLWQDWKEFLNNAQNNNYLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J533</accession>
    <name>A0A367J533_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_002140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002221">
        <property type="protein sequence ID" value="RCH84959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J533"/>
    <dbReference type="STRING" id="86630.A0A367J533"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="258"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="664" mass="76201" checksum="6BB0254E2D37A2A1" modified="2018-11-07" version="1">MRFSIQIARRRKCMYLKNPDENYIRLEPIDSSEETSRITTNGGHVSEDNKIYLADKADNLFAAQPRIIDSNRAPSDPPSPQQPATRPDRMIEQLTDGLVQLTLNSDTTTTKLDSDKVTPWRSYGQFIRWTPEPHLPSYYSVPIDMPSRLIQEQLIGIFFNECHHILPILSRSMFYDQLKVKGPLVTPLLLNIMYAHAVRKAKQSVLLPNIDVQEDVFYHRARKLVDDFLDVPRISTVIALLYMTFYECDQNRQRSSRAWMYSGMAIRMCFELGLHTSHYSSQMPQCDIELRKRVLWTCFVMDKLQSCTMERPWMLKSKDIEIDLPSQLPEDTVYERLVLEAFTQLCRLMMLVEKVIRFFTYDVKDEWTMKEENQILQYLDAIHRWREMLPMELRWTEEEIPASAVIANLHLICYDLELSLIMCCRQDQHIRDRRHALASTITEIVSLTVQYPHLMYTSAVSAFSAVFAALTHVVDFDSPELDVAKTAKVQFRKSLEDIRLLVEKIPMGDLRSSNFSRLIDVILQPKHQFYNNHHHQHQDYHNTYASAFSEINDLCHKENNLPSTSSSVDILAGRQDILDNSYIIPANNSTAPFSIESCYQHQVSGNSSPSGSVSAAAMAAAAAAVGAVGTPGSTPRSSSRSIEPADYTFELISVADEWARSLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5D0</accession>
    <name>A0A367J5D0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002182">
        <property type="protein sequence ID" value="RCH85106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5D0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10114" checksum="286EEAB79B6FF290" modified="2018-11-07" version="1">MDMGARRPTHAEKFHYLFLLYSSATTDKKLNEIIKNIKGMIKDNENTDILQALSKQKGVSSLVQSTSAPLSVANKKLAEATFNRVRTLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6W0</accession>
    <name>A0A367J6W0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine incorporator 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_006898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002039">
        <property type="protein sequence ID" value="RCH85677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6W0"/>
    <dbReference type="STRING" id="86630.A0A367J6W0"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016977280" description="Serine incorporator 3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50690" checksum="C11FE36D8F1FA587" modified="2018-11-07" version="1">MGAALSCLALPALTSLGTWVVSCFSAAACSLACKSCNCNNSVATRIGYAIIFLLNSIIAWLMLSNWAIKQIQKLPLDYLKLNCTEGSCYGIIAVHRTCFALVLFHALLGLLLLGVRNSGQPRSSIQNGWWGPKVLCWMLLLVASFFIPNEFFRVWGNYFSLTGAAIFILFGLILLVDFAHSWTERCLENMEYSDKWKYILIGGTLFLYAAAITLTGIMYGFFTPNGCSLNQFFVTLNVILSLLITFLCITPSVQEANHRSGLSQSSIVVIYCTYLVLSAVANEPNDKECNPLRKSQGPQTTSIVLGALFTFLAIAYSTSRAATQGVEGVTESSSREHLIAAVENGTLPRSALYKDDDQDDDDDERDDERYGAVYNYSFFHFTFAIAAMYVAMLLTNWNTIISEQPNSQDDSLIRIGQSYTAVWVKVVSGWICYGLYIWSLIAPVLMPDRFLVSQSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7D5</accession>
    <name>A0A367J7D5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002048">
        <property type="protein sequence ID" value="RCH85641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7D5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="10757" checksum="28C37FB68C0701A0" modified="2018-11-07" version="1" fragment="single">MRHRGLHESMMYDTFRQYKNAIKVQNDTDRLKEQIATRFVWHVCEWAHVKFNKPKLSHQGLRGYLDAIYHELKCRFCNFGNIVIFVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7R0</accession>
    <name>A0A367J7R0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001965">
        <property type="protein sequence ID" value="RCH85994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7R0"/>
    <dbReference type="OrthoDB" id="10271657at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="14074" checksum="55E11B7AD2776353" modified="2018-11-07" version="1">MHPSNERKQKQKDYSELLEELPEGIRDLLIKDTDHEADEAVNKECDEGSDSEMTIDITEKTLEQHAANIHQYNKILRPSTANSCYINSIFELLWHSVMPHFEEAMLSNFDPHNKFDSILKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7Z8</accession>
    <name>A0A367J7Z8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_002997</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01001997">
        <property type="protein sequence ID" value="RCH85861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367J7Z8"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="329"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1339"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1390"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH85861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1659" mass="185175" checksum="14FD90AF7528316B" modified="2018-11-07" version="1" fragment="single">PLSAPTTKRPIMNISVPIGTEVDYVSFSFYEPSEIRKISVKQIFNPILFDALGHPTKGGLYDPALGPFQKTQICATCSQDHFNCPGHFGHIEIPIPAYNPMFFDNLYAILRAKCIYCHQFRISRALMKKYSAQLTLLQHGLVNEAQSLNELVLDFKKTEAKDDETLEDRMEEQALSLSTVEDYIEHIDTFMKNALADEESRKFAAKDYKVTVINEVRKSVMRDFMKQCIHSKKCANCSGISPPIRRDGAAKLFQLALNKKDQAAMDRLKNQTGSFEEIKGFTNGQRFLTPYEVRKHVQALFEKEGDITTLLFGARDPRVPSFIKKATYHMFFIEVLAVAPTRFRPPSVMGDKTFESPQNELLSSILKGSHLVRDLSEELQAISDQEPVDKKKLEATRNRFVDSIIGLQHAVNSFIDSTKNPTQVAQGKNLPPGIRQALEKKEGLFRKHMMGKRVNYAARSVISPDPFIETSEIGIPPVFATKLTYPEPVTPHNIKEMRQAVINGPNKWPGATHVQNEDQSIDVLGDLSIESRIALANSLLAPQSSHTAQSGNNPYPTRTQTINKKVFRHLRNGDMLLLNRQPTLHKPSIMAHKARILPGEKTIRMHYANCNTYNADFDGDEMNIHFPQNEIARAEASFIANTDNQYLVPTSGNPLRGLIQDNVDSGVWMSSRDTFFTKEEYQQLLYGSLRPETDGTGGGKIRMLPPAIMKPQPLWTGKQVISTILKNLTWGKAQLNMTSKSKVPAKFWGPNAKEEDKVLVMDGELIHGVMDKSQFGASAFGLVHSVYEIYSPEAAGMLLSILSRLFIKFLQSHGFTCRMDDLVLTKEGDQWRRDLLDQGVGLGDEAHLEFLGLADTAKTASPEVLSKEFKLRMNEVIRDDNKLAGLDNAMKAKVNKLTSSITQKCLPDGLIRPFPKNDMQMMTVSGAKGSNVNATQISCLLGQQELEGRRVPLMVSGRSLPSFRPFDTSARAGGFVTGRFLTGIRPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLRVHYDHTVRDSDGSVLQFHYGEDSLDVIKAKHINQFGFSAHNFEALSQKYHPKAALASLEIKQGEEYAKKALKKPGKYDPALSVYNPGTHLGVVSERFALAMKNYIQKNPDGMPFEKDSQLSKNTARYAGLTKNKFKALMNLKYLHSLVEPGEAVGLLAAQSVGEPSTQMTLNTFHFAGYGAANVTLGIPRLREIIMTAARKIKTPTMLLPLLPETSAKKATQFCKSASRLTLAQLVDNVVVREKTSAKTADNNYKRSKTYSIRVNLFEEKEYNEEYRVSAKRVKEVLATAFLKDLEELIRKDIKDTKKIEDISKAHKMDAPGDEDANEDLGDAAAKGGYASDDAEDMDAKTARKSAQNKPQASYDEPDEDDIVPEDNEKSLEDEEEEFEQAILAGADDEEEAPKRSSSKGGKLEEQAVQKSKYCTRFKFDDNDGAFCEIDMEFPADTKKILMISLIEKSCARVVVHEVKGISKCFEYINPTENDTSKRLQTEGVNLRGMWAFSDIIDVNYIDTNDIAAILNTYGVEAARNAIIKEVASVFAVYGIVVDRRHLTLIADYMTFEGGYKPFSRIGIGSNVAPFLKMSFESTCKFLTEATLHGDFDTLDSPSSRIVVGRVVEGGTGSFDVLQPLTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J918</accession>
    <name>A0A367J918_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001869">
        <property type="protein sequence ID" value="RCH86428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J918"/>
    <dbReference type="OrthoDB" id="2289386at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="144" mass="16593" checksum="CD6776F899CF88EB" modified="2018-11-07" version="1">MEEFNTIKEKISINDWNPNEAEAKLLLAIKDCNAPYRALRVAICTSAISPESFGAYVHHNMLEFQGSFIMNENYERTCASSVVIPIVRQIFKRNVELSTKWFERQSQFTNKHHFDAVISIDSQASQMVIYDIKMCVYVVTAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9V5</accession>
    <name>A0A367J9V5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1751-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001805">
        <property type="protein sequence ID" value="RCH86732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9V5"/>
    <dbReference type="STRING" id="86630.A0A367J9V5"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35706" checksum="2771760A2173BFE9" modified="2018-11-07" version="1">MSFKMNLVTNVPSLTKALVSTLFCVSVGCYVYIYRTSLDEPKQTVCPFIGLVPGFIFYAPWTLLTATFYENNPFSLTFSIIVLLFCGKYLERAWGSRELLKFIVITAILSNIVTWFGLVFTFYLSGDDTYLYQIQINGMAGVFSAFLVAFKHLVPEHRLAILGGKISIRVKNLLGVATAVSIASLILMKAIVFYNLVNIGWIIGWIYIRFFKYQDGIQGDQSEAFAIHTFFPEFLHPVVMIISNHVYDLLVKLKCCKPGARSYRDLELGSTTPQPGSARAEAERRRALALKALDMRLSKPQEPTSDNSVIFDADEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAJ6</accession>
    <name>A0A367JAJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001756">
        <property type="protein sequence ID" value="RCH86972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAJ6"/>
    <dbReference type="STRING" id="86630.A0A367JAJ6"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH86972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="39615" checksum="588EBADEE4F9DDE4" modified="2018-11-07" version="1">MLTTTPYAYPMKRIEEKGDMVTMIDYTNLYIKNLDINVTSAELFKLFRVFGHIISARVMKDANTTLSKGYGFVSFKRMEDAREALIQMNGCLVQTKHIIVNYHEHKKTVQQYQKMQTERNRQMIRNKSEVSYSPEQKFIQPWHETIWMHPMYPPMQNIPAVSPMTLQIQKLREAIDHQLLDYQKKDLNELVDLIQSLKKRELSLCLFNPAFLKQKIAEAYEVIHLFKYPENSIATTPSLDHHHLNDDDNDSSPNSSVAAILSSLEGMTLNKKKRVFGDIFFPYVKATGIRHAPKVTIHLLDTVPLDDLAFNMYDKKTLTKKAHQAYIEIYGDGSNAFRELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB85</accession>
    <name>A0A367JB85_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001709">
        <property type="protein sequence ID" value="RCH87188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB85"/>
    <dbReference type="OrthoDB" id="2240073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="507" mass="59229" checksum="0733B3E6C7E2717E" modified="2018-11-07" version="1">MSIFERSLYAYDPNELEDLDDIFNEESSQLISLSSIDDNQLDELTRSLVTPTPNKYRATSSPYAESVQLFRNLKDTATVDDLVHSDLREFMDHYDMDDLLSSRPTSSIKFPSRTTNIQDFKTSTRRNTNNEDRKSQLLSALEQSYIRERQMEQVYLDQLKEIDSKAYERLKRDSEAFMKRRSSLLQHFRNSCEPSVPRYTLEKTSQSMAPSRSSGNSTTTSSSHSNDVYYDPPSPSSKRYSQCLDRNREVIFHRQGLDEPNIDQGIIKKNVPDLTKSPIVRPVVTNYNYLTRTKRTNSEAQERPRVESYSLRRASEEQPRGMARRSSRQQDDVSRARRMSQMNVESYLAHPRRISEDSMNRSRRTSEDNKYKTETYLARPRASVHDITARPREDKTDRDIALSYLNRAQKRDSTERWSLKKPVVVNEPRVSTHITQDKLNNRSSLKRNSSVEDIRKRLSYLSTDNKRYTMEPVKTEKEMATESAKRVLAMVQERRSKRLSYTGRLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBR0</accession>
    <name>A0A367JBR0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001673">
        <property type="protein sequence ID" value="RCH87367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBR0"/>
    <dbReference type="STRING" id="86630.A0A367JBR0"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="173"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="461" mass="51023" checksum="88BDA56E9210FF5F" modified="2018-11-07" version="1">MSINITIHKPDDASTELPPPPPYSREPRTSDAGTYGNINEEQVRLLGNTPPIPKPPNNNHGFSDGPYAYHTNTQTEEPMEHTSRRRYPCWCTFIFVVILVTFVTYTFKAKSVRGGRCSGLLPWEKFPETIEFERNINITLDGRVSSGQLTIIPVESGGSIKGTIETTPDLQENISLDIDDNGSITTVLLKTPKWAHNCIRVNMDIYLPYNAREAFITFNNVDIKVEPLVMDLKKLYIKNANGDITLNNWTGESLQISNANGIVSVAEQLRGDNLISIKNKNGPIDLMDVKANGNAYLTTSNSRIQVLGSLQVDDQVHIQSANGPIQLSGRIVSNRFNVETANGNIQVLGEIVAKEKAVLRTSNGHIVANIAGEKNNNVFVASSNGWIDLHMTNEFEGKFAFTTSGSGKIHVAEDEQVHYVENNNYIKRGYRHKPDDRGYLTVMTSNGGIKAAFDIDSTSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCK3</accession>
    <name>A0A367JCK3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SMC1_2</name>
        <name evidence="8" type="ORF">CU097_010836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001614">
        <property type="protein sequence ID" value="RCH87657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCK3"/>
    <dbReference type="STRING" id="86630.A0A367JCK3"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="27979" checksum="12838670FD8C8250" modified="2018-11-07" version="1">MDVDEPPSQTSILTSDWTIEIDYARLGQLQRDDSSQAVDKDFQDEIKRLTDEIEQMAPNLKAVDRLESVEESLKVAEDEFSVARNAAKTAKERFNAIKQKRFSLFYDAFSHISEHIDRVYKDLTKNETFPLGGTAYLSLEDTEEPYLEGIKYHAMPPMKRFRDMEQLSGGEKSVAALALLFAIHSYKPSPFFVLDEVDAALDNANVSTVASYIREHATDEFQFIVISLKQLLYEKAQSLLDQYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD54</accession>
    <name>A0A367JD54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001579">
        <property type="protein sequence ID" value="RCH87850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD54"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="156" mass="17303" checksum="384BC56BF02B542A" modified="2018-11-07" version="1">MSNEAGPSTITIPEQADLAPKSQIFETNLIEDIFDYSILTSNDVSMARDMLANERNWLTWLRLSCTLIILGFTVLLRLRLPDPSEEAINNHPTRPIGYVFIAVGLGCLFVGVGKYFKNQRLLIKQATFVQAGWGSFVMVGILAIFTCTIMIIASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEY8</accession>
    <name>A0A367JEY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane and coiled-coil domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001457">
        <property type="protein sequence ID" value="RCH88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEY8"/>
    <dbReference type="STRING" id="86630.A0A367JEY8"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF23">
        <property type="entry name" value="DUF726-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55661" checksum="27FC8CA5E4CA5174" modified="2018-11-07" version="1">MPNDKPLIKLSVKDWTREQRMAIARVTSQALTNCAMGEPWSTDYWNKLLSYLDLTQKQLCVLTLDQAIDMLSSQKDIRIDVMLDLVALSIYGHQKAEMYYDARARSLLLELERCLQLSCGDLNAVERSVSQQIYYALQEQQSSSHTDNMGASAKKAVQDGNKKQQALRWVATGAGILGGGAVIALTGGLAAPLLAPLLVGVTGAGFFATAGGVALITSLFGLTGGGLAGWKMHRRMKGIDEFEFRQILRDPDLPPIPSLHCTICISGFLLESANETKAPWEHAFEGKHGSGSDIYCLEYEKKELLDLGYSFKRFVKDSAIKYAGMEVAKSTVLHAFFAAVALPATILKMADVIDNPWQIAVDRSRKAGAVLADVLQQRVHGNRPCSLIAYSCGCLVIWHCLLELYERGCIGIVNHVVLMGAPLSTEDEQEWLQVQSIVSGRFINCHTSNDWVLAYVYRLHSLATSVAGLEAVKIGRIENLEIPELDGHTKYPYIVKDVLDQIKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFR2</accession>
    <name>A0A367JFR2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-dependent helicase NAM7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">UPF1</name>
        <name evidence="17" type="ORF">CU097_006343</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001402">
        <property type="protein sequence ID" value="RCH88812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JFR2"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="16">
        <location>
            <begin position="334"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH88812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1287" mass="146036" checksum="4BE9182C46F181FC" modified="2018-11-07" version="1">MSMLQDFPLAFAENRLKSDQDSVCYLSWLNTDTEFPELSDSFGVEGPCWEILEKREAYDDEFEFVPVEENWSKLVETKKLQPYAKITERAASLPHPKRKIQPLFTVRKDKSKDDGANLSDEEVDEDDICTELYLTRKGQSKRSNRNAGLRKLGRLKMVDQYVQGVIFLATTRPGSKAATWLPRSVLQGTYPGPNGLALYPNTKTEAIVYTEYYIHRISKSNFMDWGEGRKRLLDPAEYSIYTPISRRLKMDHFEGASQDDFTFLEYSADTQSSQYEYNDFTQTQKETEIDLPISSLSLKDERENAVANGTTSFVNDFQFEDTDDFGELANAVEEKDLPPHACKYCGIHSPASVVKCVTCDRWFCNSRGNTSGSHIINHLVRAKHKEVALHPESPLGDTILECYNCGCRNVFLLGFIPAKSDTVVVLICRQPCAAMPSSKDMNWDTTQWMPLIDDRCFLTWLVKIPSDQEQLRARQITSQQINKLEELWKENSEATLEDLEKPGIDDEPHPVLLRYEDAYQYQNIFGPLVTMEAEYDKKLKESQTCDDIVVRWDVGLNQKHIAWFYFLKLELGEIKLAVGDELRLRYRGELHEPWESTGHVIKIPNNISDEVALEISRGLNPPVECTHNFSVDFVWKSTSFDRMQIAMKKFAVDEASVSGYIYHRLLGHDVEPQVLKTQMPKRFSAPNLPELNHSQVYAVKSVLQKPLSLIQGPPGTGKTVTSASIVYHLAKMNPGQVLVCAPSNVAVDQLAEKIHQTGLKVVRVTAKSREELDSPVSFLTLHEQVQNNDTNVELQKLIHLKRDQGELSAADERKYNALKRACEKEILANADVICCTSVGAGDSRIASLRFRTVLIDEATQASEPECMIPLVLGCKQAVLVGDHQQLGPIIMNKKAARAGLCQSLFERLVILGIRPIRLQVQYRMHPCLSEFPSNMFYEGTLQNGITTQERIRKDVDFPWPVPETPMMFYANLGNEEISTSGTSYLNRTEASNCEKIVTRFMKSGVLPSQIGVVTPYEGQRSYIVQYMQFNGSLRKDLYKEIEVASVDAFQGREKDYIILSCVRSNEHQGIGFLSDPRRLNVALTRAKYGVVILGNPKILSRHPLWHHLLVHYKEKGCLVDGPLNNLRVSMIQFNRPRKSYRKDDKFRQGLAHQVDAREAFAKAPLPNDTRRGAKGYDQDFIQTHDPVGYIPSELGSLPSSQFSIPFIPSASGPFTQDLSQSSVFNRKKQTGEDMLENTQRYIPGSSTFVNHTLAWQQMGESQNMYSSQTSIGLALSQSDRLRMDMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH46</accession>
    <name>A0A367JH46_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001318">
        <property type="protein sequence ID" value="RCH89278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH46"/>
    <dbReference type="OrthoDB" id="2290043at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="32362" checksum="9A6831DBEC5736A7" modified="2018-11-07" version="1">MHTTANCPLRSMAWITLDDHSRVIEATKEMKELLGYNPINQTIDSLWKYEKNDGAYLIVNTIYNSRTLCICLHTQKEGKVLVCLDITDLKNYQTNTDVSCSIFRLSMYGTIEAVISNEEYGTSWIGQPMMRYIHSDDVEKFCMATSQATRSPSFLVQLTLRLLPSPEQQASFECTFLSVDQQQLLCFIQPTSNYIQHIVTQAQRKFWQTFEYGMTTVAHHLSQSLLLLAKIMRGCHKKDEVEFLCTVASYIGISPLTTKGWLNQFVDQTFEWFVHDSDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK48</accession>
    <name>A0A367JK48_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Checkpoint kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CHEK2</name>
        <name evidence="7" type="ORF">CU097_000909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001149">
        <property type="protein sequence ID" value="RCH90265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK48"/>
    <dbReference type="STRING" id="86630.A0A367JK48"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="362" mass="41683" checksum="3C91E7614B9A47D6" modified="2018-11-07" version="1" fragment="single">MTTTKRGRSLVRKKSEIRHSGGHSLRRLYSSPSMSCNLFGNGKVKPRLLTTTTTTSKVLIKDPSTSQLKVENNEDAWGYLVREGGETYTLDRELDKRLDNQAAGYIIGKKEDCDIRLYLKGASDVHAIIYCRHRSINNVERFVPYVFDRSSNGTWVNFKKIQNGAIELKTGDIIHFMDPKLYNEAANPTYKFVKPKTSTTRARAVEDLYVLKSRIAEGTYGVVQLAECKRTKKRVAIKLIRNSMCHGRKKLRDAFLKEISVCMSMPVHPCIIQISKVYEQDDIMYIVMEYGKNGDLFECVASYQFKEYEVKIIFDQIAHAIAFLHERNIVHRDIKLENVVIFDRERLIVKLCDFGLSTFMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK49</accession>
    <name>A0A367JK49_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010253</name>
        <name evidence="4" type="ORF">CU097_011499</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001140">
        <property type="protein sequence ID" value="RCH90322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000314">
        <property type="protein sequence ID" value="RCH97033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK49"/>
    <dbReference type="STRING" id="86630.A0A367JK49"/>
    <dbReference type="OrthoDB" id="165058at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24421" checksum="21464A77D15B4EC2" modified="2018-11-07" version="1">MSTFKTTTTTTTTSTTAIPQSPSKVSKFLLDPWSTAKVVVPSAAIQLILHKTVISKTTLRELTLGLTLLNAIWFATTLNLSYLETPLLANVPSLDEWQKLDVGRHRFSWINKIEAAVSLISLDMFLNWNGRIIKHNGFVDNALKAAVIAPVAITVIQSVYFLPRLNKRAAQVSRAEVTTKELWDRDPFFLKGHRGYIALDTIKVSALAVAGLRFGLMLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKL3</accession>
    <name>A0A367JKL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ammonia (Ammonium) transport outward</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001123">
        <property type="protein sequence ID" value="RCH90425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKL3"/>
    <dbReference type="STRING" id="86630.A0A367JKL3"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25261" checksum="FBBF1CF76EF587A2" modified="2018-11-07" version="1">MTEVATNNNNQADLEAKYQVPSPQQQQQQQQPQIITTPVYAAPTVANPGPLGLSSFALTTFVLSLHNAGAGLPADGPNNVVVGLALFYGGIVQILAGMWEFRTGNTFGATAFSSYGGFWLSFATIFIPGFNVLESYAKVPSSVLEQSLGIYLLSWAIFTGILLIASHRSSVGLISLFFFLFITFILLAAAKFNNSLTTQVAGGAFGVITAIIAWYNALSGLLTKDSSHFLLPTGRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKT6</accession>
    <name>A0A367JKT6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001108">
        <property type="protein sequence ID" value="RCH90526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKT6"/>
    <dbReference type="STRING" id="86630.A0A367JKT6"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="162" mass="18749" checksum="AF7D4C41504BCFEC" modified="2018-11-07" version="1">MLDQVHDDDDVWADSDGESSLIYERNLAEKEWERLQEDHGNTGYKEGIVEGKEVNMQRGFDEGYKEGLSVGKAIGKLRGLVNTRIIFYQKLLKNEEAAKELESLLNEIESIEVNHIYTADYFRKDGPKDKDGYIAPEEFVRKLQDKVNAQLQIVSKKFSKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLS9</accession>
    <name>A0A367JLS9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatoproteinsis-associated protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPATA13</name>
        <name evidence="3" type="ORF">CU097_012652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001058">
        <property type="protein sequence ID" value="RCH90855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLS9"/>
    <dbReference type="STRING" id="86630.A0A367JLS9"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053086">
        <property type="entry name" value="RhoGEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="62"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="190" mass="22160" checksum="5279A49965D4859E" modified="2018-11-07" version="1" fragment="single">MQPSIPPWQIIIATPVLIETTDSFCSCCSCLSSISEGREQPLDGPSLEQPTMSPDEEKMTKKKLHAIDELLQTERDYVQDLSHLVEVCLQTLSKQQWIDNHHKSIIIRNASDILLFHKQFIVTFHPVAHHWSMIAKAFLDQISHFSLYKQYCDLQNEACQLVSSYRNRPEWNQFLKECLDTQDEEIMQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLT1</accession>
    <name>A0A367JLT1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_010501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001052">
        <property type="protein sequence ID" value="RCH90892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLT1"/>
    <dbReference type="STRING" id="86630.A0A367JLT1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="481"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH90892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64240" checksum="63547FEA3213B6EE" modified="2018-11-07" version="1">MQLNLSSLFCSKTLPTISATEYESVCTNRKSIVIHGDALRTRSMDNITLFDLLFTKEYNRTPSDQIVFAEASDPNNHITYGQLQDQVLRCAFGLKRMFNIQHGDVVVICSPNSLEYPVLFYGIIAAGGVAAPIRHSTYSSFEETVNVINIIQPKAIIVHESEIQTVFPAAEKAKIPMSNILVITSCIDYIKDTYAGAQVVDSNLFSNGEAAEPYPYTKDDLMNSPCCLYLTSASTGDCKVVMIQQSSLVCLLLNGPYITPPLRCLALSLFSFVSGLRCHLLVGLFCGSTTYITKDKERTLEDICKAVQRLKINFMIGVPCLASGLVKQLNIAKRYDLSSMTRAFTCGTFMDKSIIRLARKHLNITFINVYGMTEALEIFANDEEHSLAGSVGRLVYGALARIVDEDGNDLPIGEEGELRIKSPMVTLGYQRNPEATAELFDNQGYLKTGDIFRVDKDGYFYFITRKKDLIKAFVVNIFPIEIEQILINHPQVTDCAVIGIHSKEEGLEVPRAYVSLLDDSKDKHSLLEEIRVYADSQLPDPKRLRGGVFEIPVFPRTASGKIQRFKLRQMVEKGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMJ1</accession>
    <name>A0A367JMJ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CPSF2_2</name>
        <name evidence="11" type="ORF">CU097_011561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001018">
        <property type="protein sequence ID" value="RCH91115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMJ1"/>
    <dbReference type="STRING" id="86630.A0A367JMJ1"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH91115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="701" mass="78094" checksum="B5099CB9D47167F7" modified="2018-11-07" version="1" fragment="single">NMLKNCKYFVKDSIKWLPFFGWGMWLAGFIFVRRNWTQDQAKIIAAFGKVKRLETPAWIINYVEGSRVTPKKLQESQAFSRERGYPVLRNLLLPRIKGFATCVNEFRGSHIKYVYDFTLGYRHKSKLGQSAPSMVRVHTRSLWPEYEFHVHVRRFAIEDIPRDEIELGHWLRQLWVEKDEFLSGLHDNWAGHIDKQTTWKESSCMTLQHKIVIIIGSGLAGLSAAIEAHNQGNTRVILIEKEDKIGGNSMKATSGINAIEPLTGDSRDAFVQDTLKSGGGLSDESLVAKLVDESRPALDWLIKQSEFETDMPSLDLSVVSRCGGHSFGRTHRCPPQNGRPVPVGWKLIDTLKKRFMSLPDTEVLTNTRVTRLLTKQDKITGVEILNEEGKREIPANAVVLATGGYGGQTGTRLSDGHATLLSEFAPQLVHTATTNGPWANGDGIRLALAVKAGLRDMDQVQLHPTGFIDPNQPTLSTKFLAPEALRAYGGILLNGDGKRFVDELNLRDHVTDKIVHQASKVYHRPESWMHKILPKKYPAAYLVLTDEAVENFGKSTLGFYASKGFFAQVEGIDNLAKDVLGVDKKEIEQTFKEYDSHIESASPDDFGKTVFPCRLLPENPTTYWVALVTPVVHYTMGGLNMNTDAAILRQDNQTVIPGLYGAGEVTGGVHGRNRLAGNSLLECVVFGRTAGRNAAIYSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMN1</accession>
    <name>A0A367JMN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001007">
        <property type="protein sequence ID" value="RCH91187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMN1"/>
    <dbReference type="STRING" id="86630.A0A367JMN1"/>
    <dbReference type="OrthoDB" id="2280493at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051882">
        <property type="entry name" value="ATF_bZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164:SF3">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="47125" checksum="885CB3F7731C3506" modified="2018-11-07" version="1">MTELNLSMDSYMDDKDDIMTYLDEDYMSTTSNNSSSWTLPLSPSMTPTPPEPTVFPEPQYFPFMNYLQGCYQHDVSQMNAFKEIHLMLPSSTLVGPKQKRGRKKRNASKDASTVSLKPPVPILPAIKQEEDENKTDEQLNREKVAASLAKRQERLIKNRAAALLSRKRKREHLHSLEQERVKLLGENSDLKEQMNRLERENMQLRQKLKDNNHSHGSSHGSHSCGNHGILLMIILYCFALFISFLPKSKTMTKSMDNTLKEYDRNLKELERQKEKLKVVMQMMGQEWEESGPGIGWLGSLDIPDTTAEPSLNDKKKQPVLTSNLLQPTAGPSSEYLQSLLHINESLLAQSLANDPTPMLSPSEEDSLIDHKPINISSPLITPEDNQVKQDKDTLTDDCSLNNTQLEPFDQIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMW4</accession>
    <name>A0A367JMW4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_006935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000997">
        <property type="protein sequence ID" value="RCH91258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMW4"/>
    <dbReference type="STRING" id="86630.A0A367JMW4"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000010">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="161"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="32997" checksum="85C109D15166DD8B" modified="2018-11-07" version="1">MTEENTVGPLATPTRFLIESGEWNLTPNFIHEINPFDCNMTRSPGILTKEHKWSNMSTSPTSTASTASTTSTTSPNTSPKQESILSPPTPPMSLSQSPTNSSASLSISPRNSVDDSIHQDIVRRNSSTKRKRKEADDDEEYKPKSTGGRKRRIVFEGEDAEDKRKKFLERNRVAAYKCRQKKKTWMQELEQKAEISTARNEELRSLVTQLKEESMYLRNLLLTHGNCDCESVQAYLRRSSAQITSRRESTSSEFMPYYNTPSTGLTPFLNTVINKSDNRLDYFSSTHHPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JND3</accession>
    <name>A0A367JND3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001004">
        <property type="protein sequence ID" value="RCH91211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JND3"/>
    <dbReference type="STRING" id="86630.A0A367JND3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="476"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="67614" checksum="B27AECCEE530B2C9" modified="2018-11-07" version="1">MKSLCQNINHSCHHSSLLHLDVIPVVAAGLGGLFGTMYLDSRYLLSRDFHQLKAGLLANLSIRLWELQDKTHYYFRFKEKAKANPDKLFVMFEGKGYTFRHIEKVDDSLLHCLRIASTRLLLFDPVYEKQVATILDACRELNVNLIAYGESTEENELPPLPFASTLTPSVLASYSDADTSEEPLKGVKPSDAAYLIYTSGTTGMPKAAISQHSRIGFGLVMYANVTGIQEGDRVYCVLPLYHSSGMIVASSVALYAGATIVLGRKFSARRFWNDCVDYKVDVFTYIGEFCRYLLSQPPHPEERNHKVKMVYGNGMRPDVWRRFQERFNIPKVCEFYAATEAPTTLFNVNTGELGAGAVGSRGIVFRTIRSEVQLIKIDPITEEPVRDKNGFCVKSNYDEQGELVVRMDEGSHVTFGGYYKNKGATQKKILRNVFKKGDAYFRSGDLLKMDKDGFYYFGDRVGDTFRWKSENVATTEVAQAIGVYPGIAEANVYGVTVPNHDGRAGMAALVLKEGVSLDFKELYQYLRQKLPKYAIPVFIRFVPAMDLTGTFKQQKVQFRNQGIDLTQIPESEPVYWLKGDTYVPFTLDDYAKIDVGKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNN3</accession>
    <name>A0A367JNN3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARP3_1</name>
        <name evidence="10" type="ORF">CU097_010873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000954">
        <property type="protein sequence ID" value="RCH91552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNN3"/>
    <dbReference type="STRING" id="86630.A0A367JNN3"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH91552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1108" mass="125423" checksum="F4F96C6ABC8ED2AB" modified="2018-11-07" version="1">MTKLPVVVMDNGTGYTKLGFSGNNEPSFVFPTAICTRESVSSSGRPNVSSKPSFLSSNLASKRGIEDLDFLIGDEAIAQAKTMALNYPIRHGQISNWDHMERFWEQSIFKYLRCEPEDHYFLLTEPPLNTPENREMTAEIMFESFNVQGLYIAVQAVLALAASWTSNKVSEQTLTGTVVDSGDGVTHVIPVAEGYVIGSSIKSVPIAGRDITSFVQNLLRERGETNIPPEDSLRIAEAIKEDYSYVCPDIVKEFKKYDQEPDKYFKKYEGIYSVTGKSYTVDVGFERFLAPEIFFNPEIASSDFLTPLPEIVDTVIQTSPIDVRRGLYKNIVLSGGSTMFKGFDKRLQRDIKRVVDKRIQDSEVASGSRATPMEVNVISHKKQRHAVWFGGSLLASTGEFYNYCHTKAEYDEYGPSICRHNRVFNSNEELIESIRDTRAKQLQACRQRIALFKGLQVESFEDRALALEKIIQVVKSFIRSSSSRSSLSPSATSNATSPTAVMNTYIAEEDIEQPEGEKEQDDEYSEQLFYYLLTILRLSVTCPYADVRQTFKDLLNVLKETTSISIPQPRHSSPSHFISLYDIFSLESTVSCNQIVNYPRSSNLSFSPWSTSSFSLQNEENDPSMPDNNTDTSNNSSTINTIPENHHSVYFDFTGGRPSDEYVRQMMIKTYTEEGRLFNLYRILSFFPTFFETYHVTFTKIIKAPLGPLHRTWKTYIGIMVAAEQRCQYLVSILKLDFLYNGGNPDWLKGIEHVPIKLRNISGLILKLARQPWSLQSEDVVELLSGDLGDAWSKGELVQVVLIIGTILGLSSYILGCGITPEIDMSGGFCYPGGHTKGGIENELDDSHSHQDYTESEDMLFSSDNGIGLGVSIDIEETTKELISKLKSKKNSTLKEQLIESFEKLKLNNNEEEQPRKELKQSSFELPQSKEINSVYEDLQRFIDPELNEAIKLETFDSSQHQEFMLGEYCWEDHGCDLANYYLPGIGDDLVTEFTEAISITDWSIFHPIAEEVVDTSPLRYAIWHYTQKIMGVTKEDYPYTDIPTFLNERTSRYLEVLCMSPHKIQKNDWCNIGISLRPEEKCHVNLLIASARKQAILCYGLSLISEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP36</accession>
    <name>A0A367JP36_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasma membrane localization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EFR3_3</name>
        <name evidence="3" type="ORF">CU097_006681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000935">
        <property type="protein sequence ID" value="RCH91686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP36"/>
    <dbReference type="STRING" id="86630.A0A367JP36"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="732" mass="82580" checksum="AECDD06F7DAE3617" modified="2018-11-07" version="1">MATCSSCRSKHVNLIEQCYPGKEGGTTPRSSELSYLTFYANSRPAKLSKVGSYIQKKVNKDIRKGRKENNQVSLRILKALIQSCYGDLNIFSKCLVNVFCKLLDTRDIDLIDLTCETFIVFCNYNDGSTLGIDVNFTQDYEALLKKFSSFCDYSNDDTSFELKMKYIGQRGIQAAVTSQALVSSNYKQQLGILLSPLMDVLTSTAKLSTDSTDGTIDIRESALNNNKLGDSYIQLIATHTLTILFNKLTGHYVRVTLGLLFDYMNRHKKWWPSDLSVSIMTIVVDSTQSQYRQLFLSEILQQLDPEEIMSDKQTALVCIIDAVLNASTPLLGVSVLEVLNSLFTLLVKAARYSSEEDKQRSTIIQKGLIHSIEGLASHTYYDNQLSDMAGYLVSKLKPHTTLGSVDHLPILEYRRLALSCLDTIPSLPLDSFNNGMGLLEDKDPQTRLLFCKSLYQKIQTNSSQKSTVFLDRLLQAMYNWIQLPNLNLTDIRFFFAFSCILHPMFGMQATIMLVSLLFKVQEWVQEQDLQKQWVIQSLILAWLGKTAEFYQLEPLVEYLGQFEQLTLGLTEKPSMEIELTKPLPSIEETKPPVWIDRSRIAEIISSEARLREEQDTHGLELEAKLFAEWGSETLMKHSTRLIQGPNDSKPKLSSPWEQAPIGKISNERRGSIKVSTLKEVLVTQTNEDSDSTTQASSSPSEHKPSLNALLTELKLPPNNTATFSLVNPPYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPE8</accession>
    <name>A0A367JPE8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000917">
        <property type="protein sequence ID" value="RCH91807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPE8"/>
    <dbReference type="STRING" id="86630.A0A367JPE8"/>
    <dbReference type="OrthoDB" id="2264205at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="30258" checksum="B0EA1B75A513D69D" modified="2018-11-07" version="1">MTLYISMISFRSSASQADPNGIDPIVIETVYWGESDKALYKLAIDQFEDFVGQLVHCSGTNRYLEINFDIDDYRSCAFDTSLKFDNGKMILLAGLTATLSNYGIVRDIGVVNDNATSTFLSSGYAILDVSKQSLIQDESPFLELSHVITWVDPDASRSDKLFILANWNDMSTYCHESGHIASSCPKSLSGKRICFFCLKRGHVRTDCPERTSATKRRRNGRSVARPPSSIQSASNLKSQRQKHQVEIILMQGQHSEISEETDPPVPNSSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPS9</accession>
    <name>A0A367JPS9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epsin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ENT3_3</name>
        <name evidence="3" type="ORF">CU097_012387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000908">
        <property type="protein sequence ID" value="RCH91879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPS9"/>
    <dbReference type="STRING" id="86630.A0A367JPS9"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="414" mass="46366" checksum="FDE4C537875D1DC4" modified="2018-11-07" version="1">MNTFSNFQIPDVWEVKDVINKVKNVVLNYTEMEAKVHEATNNEPWGASTTLLQEIAQGTHNYQYFNEIMPTIYKRFTEKEPKQWRQIYKALVLLDYLIKNGSERVVDDARSHVAMIKIMRNFYYIDEKGKDEGLNVRNRAKEIVELLADTDRIREERKLARKNRNKYIGVGSDTASTRYVGFGSSSRGISFNGDAMSFGEQTPYSPPKMGKYDEEDDEFDSFASPSTTISNNEPKQNKSNHENDDDEWGEFTYGGVAEEEKIKTSTTANDDDFADFQFAVPERSNNNNNAQQSSTSNDLFDLLGGDVSAPPTSIPQTSPVSPQQTIKQEKEIQGASTPATGMWAQASNFVSLDSLGKKSDTTLNAKTGPSMNSLKSTSAQASWNNWASTNIVQSTVNNQSKNTKSSSPFDDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ56</accession>
    <name>A0A367JQ56_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TIM54</name>
        <name evidence="13" type="ORF">CU097_004736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000890">
        <property type="protein sequence ID" value="RCH91999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ56"/>
    <dbReference type="STRING" id="86630.A0A367JQ56"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH91999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="38953" checksum="4CC48DAD86B57180" modified="2018-11-07" version="1">MPLPFGLKAPSKGTLIFSGIAGALSGIIYTSNKNAEESRRKVAQRVAHLADRPCGVHEMPRKVTIYISAPPGDGLEKSRTWFREYVKPVLVAGAVDYEVKEAKEPGQIEKSVMEAIIEQRREAESSIMEIDEQQQSEQQQQQQQQVANPFVAPNVKEMISQQLKKRKETDGILAIGRNAYREVLSGLAKGCEASLEQKNEEVVKEKPAEMEQQDQEELINEGIQQVNNEVQDEVRFSLPPKFEPVMYIPHVNIIGWSNIPYRLYMWYADYKRIEEVGKYTIAAVLNQTRPMEPRDADKGQEEKKYWIGDEKVEELKKNDEPIVIDERIMDKLTTYTSDELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQB6</accession>
    <name>A0A367JQB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000871">
        <property type="protein sequence ID" value="RCH92142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQB6"/>
    <dbReference type="OrthoDB" id="2270129at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="22534" checksum="EACAE84BD7FEEF24" modified="2018-11-07" version="1">MVQYLSSAYYSTAQELINLASTCKNITAGPDLYQLYCQSTADPVGSCYSLPSKYLNKDGSVDCFTVTTSSFLTMIYQTTGNVCGIHCYYPTSFNFPSISIPSFNIPTYSYPSQTTTTPASKSAIGTPPATTQQPSAFETFSIAAPASGNAQSTPNANTSNNNNSGNNGNSPANGPFVGGSGLLSSSHTIGPNFILTFIVLFLMMSIFTRRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQD2</accession>
    <name>A0A367JQD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_012149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000875">
        <property type="protein sequence ID" value="RCH92116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQD2"/>
    <dbReference type="STRING" id="86630.A0A367JQD2"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="515" mass="57702" checksum="F6AE922B0AF86F8E" modified="2018-11-07" version="1">MNRQRRNSEAEHRALYKRTSISRKPEELMKRRMAIDEALRKKHREQLITAKRFRNLTRREEYESAGEEEPELEKTSEHDDEISPYYRLTPGQVQALANDLRSSDASTRIEAAQYIGKFVLEPAEALIKYITEEDCILALTQMISGPNLEEQIEAAQTISNIAAGPYELWKKSTLAVPYLISLLDSDNMNLREIAAGALGNMAAEDLGDMNDEDDKIRAMIRNNGAIKPLTRMLDTNDVRLIQSACFALANLARGEEKELEEFLNVGLIDKLANHLSDDNDTITEICWTISYLTAGSEKCRQQVMNKGLAAPLVSVLVSLSEQGSLVLPVLRTLGNLCGSDDNLKVLADQPGLLSTVIKLVNSEERIIKKEALWVLSNITSTDNRYIIEQVEELHAIDSLSELLTRGAFDIRKGAAYCIMNIANHGPEHLDQLCHKRLLPSFLDLLRSQEAEMIRLALGYIELLLTQSAKGKEAIDAVPECMEALAAVTPAPDQELFVFANRLVDQYFGESPDMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQM5</accession>
    <name>A0A367JQM5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000865">
        <property type="protein sequence ID" value="RCH92185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQM5"/>
    <dbReference type="OrthoDB" id="2235549at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="73" mass="7807" checksum="6939053E71E5D97A" modified="2018-11-07" version="1">MIAAIPRSASIVLVPVTSFAGYATYVRSTSKPSEAHIEYMKSHTSLDESLQKKWKKVNNGLGLVDVGRSGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRJ6</accession>
    <name>A0A367JRJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_006690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000810">
        <property type="protein sequence ID" value="RCH92567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRJ6"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="98"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="310"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH92567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="448" mass="49191" checksum="6F7F02EB44B2659E" modified="2018-11-07" version="1">MPPNEYHDTIELISKAENSALQIPKHKHTRTGSSSSFIHFRAPLNEESQPMANPNQLASQALPSLIICIVGLTAAGWMMDIYQHWEVFTQVSELFILVPVLLNLKGNLEMNLAARFSTSANMGQLDHPDTRNALVWGNMALIQVQALVSGSIAGIFSLLLGLLLHPDETVTISNIILVISSSMVAASVSSFVLGLFMCILIIISRILKIDPDNIACPMASSLGDVVTLAILAGCANLLLDKTVSNLGSWLLFIMFSSIPFFGLAVWRNTHVRGLLFTGWTPIVIAMFISSGAGLVLERYVEQYQGLAMLTPILCGLAGNLGSIYASRISTCLHKGVQEQFRRVEWILLSMNVPIQSLFLAIVWFIDIGHLDLSLAFAITYFIVSVISTLAALKMGKSMTLAFWKYKYDPDNYVLPYLTAIIDVICTSLLVISFSWLTATGYAHLHEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRN4</accession>
    <name>A0A367JRN4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000810">
        <property type="protein sequence ID" value="RCH92566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRN4"/>
    <dbReference type="STRING" id="86630.A0A367JRN4"/>
    <dbReference type="OrthoDB" id="2504162at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="390" mass="46223" checksum="37FD1DFAF229CFCA" modified="2018-11-07" version="1">MDATILPLEFQLLFNYKLEEEEEGEILKSRNRMLPVFKVELNQVSIYRLIHHEYDKHYISAGQLFQACGLTITEGLFLFELKLSDFEVDFLNSQFPFCDIWVSVEMAKSMASALGVDYELSLLLDNALDDCYSSDNVNRNEMMHNWIVPCIPHLQYSTKALLETKFEQVEMLSSNRKIRTQISRMRQRGIVMKDKTQNGLVRWQVTAYEHHLTEQDGWVDYGSIWDSMQGLLFDLQTLSREGKLVKNERVLPNNIMVGNMPLKRDHLNHQHGLQQVYIGYMIEKMMNELNRISLKDHNTQPIENSASHHIVFHDRLDMIEQELYKMKKKGNKRIEEIEVLQQRCIQQLNEINNWKIKFEKTRQSERIWIFLFILSALFIVYYLYKINITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSE1</accession>
    <name>A0A367JSE1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_003173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000770">
        <property type="protein sequence ID" value="RCH92860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSE1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="85452" checksum="AC3799D39A23CC55" modified="2018-11-07" version="1">MTDEKKEEVLQTEEKVETTTEIKQEHHDEFWLRDSKDVKIDEESKHFDTEHHEETDEIDIAIVNEIAVTDDDPTLQAFSVRALVVGVLLSALSSSVSQLMNFKPVGVPLSSVFMLILAYVFCNLWYRLLPKGGWLNPGPLNYKEHTCIYVMVSSANTAAYGTYILGAQELYFGQSPGPAGSIFLLLATQLVGYGIAGQLRPFLVYPANMIWPQALPNISVLKTFNTDKDEARYRTKFFFIVFAGIFIYEFIPQYMFPLLSSISIVCLARRDSSVVQNIFGGAAVNEGMGIFNFSFDWNFLLNATPLVIPFWVQVNYFLGIVCIWIIAPLLYYSDVWHAKSYPFLSNGIYRRFDNGTSVKYPQKEVLNPDMSINATALEEIGYPQFAAVYAFSYIVLNFGVTATISHVFLFYGKQIWSQFRQAWKSSVNKDMDIHQRLMQKYKEVPNWWYYIIFIGGIGLNIGIAYANQSQLPWWGVIFAIALSTILSLPLNLIYAVTGSNFGLNVLTEMICGFIMPGYAIANMYFKTLGYNTMSQAGLMAKDLKIGHYLKVPPRWTFFSQMAGTVVGCFFNYIVNKIIVENEREVLLTPGGNQFWSGISPQTINSAAITWGAVGPNLMFGPKSNYYIVLWALLIGFFLPVPFWLLHKKFPKAGFQYVNIPTLLMGMAIIPGAATGWITVGFVLVVISQYYLKRRYTAWFSKYNYLLSAALDSGTSLMVFFLSMALQGGGNGQAYPFPTWAGNRADLPFMDYCCAECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTX1</accession>
    <name>A0A367JTX1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-protein Rab-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RAB18</name>
        <name evidence="3" type="ORF">CU097_000357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000704">
        <property type="protein sequence ID" value="RCH93390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTX1"/>
    <dbReference type="STRING" id="86630.A0A367JTX1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="55" mass="6071" checksum="862583934BC4609B" modified="2018-11-07" version="1" fragment="single">MSQQQVPTLKLLLIGNSNVGKSSLLLRFTDDTFLPQEEVSATIGVDFKVSMMEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWL7</accession>
    <name>A0A367JWL7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000593">
        <property type="protein sequence ID" value="RCH94298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWL7"/>
    <dbReference type="OrthoDB" id="2287696at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="109" mass="12391" checksum="5ADF565131188330" modified="2018-11-07" version="1" fragment="single">MSKVVANSQLLSPFESTQQTDIASRRKRSFSSIPAEQVKETPNKRTKTKRTLKESTETSFSVWIGATVLEEKEPVTAAFSVFYGPADDRNYTKKLQFEKKQTLIDVLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXW7</accession>
    <name>A0A367JXW7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSMC3IP_2</name>
        <name evidence="12" type="ORF">CU097_012521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000534">
        <property type="protein sequence ID" value="RCH94842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXW7"/>
    <dbReference type="STRING" id="86630.A0A367JXW7"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="10">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="11">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="219" mass="25232" checksum="282D24E38743C0BF" modified="2018-11-07" version="1">MAKKKTTGGSAKEEEHAVLEYMKKVNRPYSATDVFNNLHSKYSKTHIIKALDKLVEEGKVMSKTYGKSVVYSIKQDVVESDETGQTLDSLEVEINKVSDELNAVKNENKKLEGELSKLKSDLTTKEVTELIQKYKQENDELEQRLNHLKSGVVLIPPEKRKRADEEFTRNRDQWKKRRTMFQTIFKTVTEHMPGKPDELKEELGIEEDSIPYDKDPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYG4</accession>
    <name>A0A367JYG4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FIM1_2</name>
        <name evidence="8" type="ORF">CU097_012184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000523">
        <property type="protein sequence ID" value="RCH94935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYG4"/>
    <dbReference type="STRING" id="86630.A0A367JYG4"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="117"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="262"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="386"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="505"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="617" mass="69729" checksum="C45B93BEAACC2556" modified="2018-11-07" version="1">MVLNAFTLQRKYPQLQVNDINSLIDQFNEIDLDQDGYLDYNEIQKACKETGYSSNYDEIRATLKDVSTNTVGKIDVEEFIELAAKLKAGGNRGAFDVHQNKIKVHGTNANVTHTINEDERTEFTRHINGILAGDSHIGKRLPIPTNTMQIFDECKDGLILCKLINDAVPDTIDERVLNVKPKLNNFQMVENNNIVINSAKAIGCSVVNIGPTDIIEGREHLILGLIWQIIKRGLLSKIDIKQHPELYRLLEQDETLDEFLRLPPDQILLRWFNYHLKAAGWERRVSNFSKDVADGENYTVLLNQLKPESCSRAPLQERDLLKRAEMILDNAERINCRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLTEEEAPEIEPFDAEGEREARMFTLWLNSLNVEPGVYNLFDDLQDGLVLLQAFDKVVPGIVNWRAASRKQPLSRFKQIENCNYAVRLGQELHFSLVGIQGSDIVDGQRTLTLGLVWQLMRENVVHTLQSLNKNGRPVSDQDLVRWANETVQRGGKNSRMTSFKDPSLSTGVFFLDVLNGMKPGYVDYSMVTDGRTEEDAFNNAKLAISIARKVGATIFLVPEDIVEVRPKMNLTFIGSLMQVDKGIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYI2</accession>
    <name>A0A367JYI2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_012351</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000547">
        <property type="protein sequence ID" value="RCH94711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYI2"/>
    <dbReference type="STRING" id="86630.A0A367JYI2"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="494" mass="57608" checksum="BF4D742EF9EF00C1" modified="2018-11-07" version="1">MFKSKSRRVNRFSAAAEAATNGVYMDIGRDYDLQSEYPFRLNFYLRPPPSEITIEELEEYALDRLQVLRCIERALISGKDLKVELQKAIDKYLPLKSNASKADSLYEERRKDHISHFMLRMAYCRSEDLKNWFVRQETTLFKFRFDQESMEEKKAFLQQLNLNWKMLSIEEKEGMRQELEACCFSLLRSRSDNVSMPVVEQFVNSETFFEVDFEKVPNMVGSRLVYLKGGKAYVPMSEQVNIVLNEYREFLYKSLEATASLLPRMEEDGRLKPFLLNMEKQYIGKSYNNYDPNHSGTVTANEVDSVVRQHAPLCMRHLHDGLRASKHLRHHGRLQYGLFLKGIGLSVEEALNFWRRAFSDTTDDKFQKNYAYNIRHSYGLEGRRLNYSPYSCSKIINEQAPSTGEFHGCPFKHSSQKSLEAKLYKDQISKGHVDEILRLAGDKHYQLACTRYFEVTHPGIKDKIDPIEHPNQYYELSKKLADGDVKQDAMNIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYY3</accession>
    <name>A0A367JYY3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000501">
        <property type="protein sequence ID" value="RCH95105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYY3"/>
    <dbReference type="STRING" id="86630.A0A367JYY3"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="303" mass="34337" checksum="0987433B6069CC0B" modified="2018-11-07" version="1">MSLSTQRERGYVEVAKGREDPAVKIYYELHGNGPEHVVLIMGLNTTCLAWEHQTKYLAETGKYTVLIFENRGMGLSDAPKGVYSTSQMAHDVIDLMDHFGWTKNVHLDGVSMGGMIALELVSRWPERFSSLVLTSTTAGRQIPTWRALTTLPRLIFIKDPAERISQSLALVYPPQWLAAKPTQIEYEQYQTNQDLSLALQLARMDRSRPQTLWGNMAQMAACMTHHVSEARLQKIRETGIPILVMTGTWDHLVNPRNSYYLADKLGAELKVFEGAGHGLPGERQAEYNQQIDEHFTRAIKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZR4</accession>
    <name>A0A367JZR4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000470">
        <property type="protein sequence ID" value="RCH95410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZR4"/>
    <dbReference type="STRING" id="86630.A0A367JZR4"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="242" mass="27326" checksum="3D1C4E6B3EA4FE37" modified="2018-11-07" version="1">MTTIQRKEEIVYNLTTVRNNMQRVLNEQQREACLVAVSKYKPIEDLMYAYEAGQRHFGENYVQELVDKSQKLPADIQWHFIGHLQSNKCKTVAAIPNLYVVETVDSIKKADTLDKACKAVERKEPLRVFVQVNTSEEDVKSGVDPSSAVDVCKHIIEQCTNLKLQGLMTIGMFGRDPSVENPDFKCLVECKQKVENELSMKGLELSMGMSSDYEMALKMGSTNVRVGTTIFGGRPPKTEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZT8</accession>
    <name>A0A367JZT8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DUSP12_2</name>
        <name evidence="5" type="ORF">CU097_014364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000460">
        <property type="protein sequence ID" value="RCH95502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZT8"/>
    <dbReference type="STRING" id="86630.A0A367JZT8"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="171" mass="19254" checksum="F8D3A999C83982DF" modified="2018-11-07" version="1">MSNQEQVQFALDPEYSGLSNVEDSKKPFKGLRCRKCRRLLVGAEHVIDHEPGKGQMSFSYHKRNADISATTTATATTTDTEPLEANKALNPLLAALAAKNNTCSSYFIEPMQWMEGFVEDVQGRIDCPKCRCKIGNYNWSGDQCSCGRWITPTFMLHRNKVDEIKRIAFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K073</accession>
    <name>A0A367K073_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_002223</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000480">
        <property type="protein sequence ID" value="RCH95301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K073"/>
    <dbReference type="STRING" id="86630.A0A367K073"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH95301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="374" mass="41771" checksum="CF0C83093F20767F" modified="2018-11-07" version="1" fragment="single">MYKPTGTNVTPLGTKRRFGDAPNGIKDDSNERNSANANSDQSGSPNSAAADSTPKRKRRSRWGDEQKIIIPGLPTAINKIDKEQSEKYLLQIRLEEINRKLRTGDYLPSETRGRSPSPEPVYDANGKRVNTREARYKKKLEDERHRLIEIALRTIPNFRPPIDYKRPTKLQEKVYIPSKEFPDINFIGQLIGPRGNTLKGMEAESGAKISIRGRGSVKEGKSRTDAASNAAQEEDLHCLVTADSEEKIKKAVKLIEKVIETSASVPEGQNELKRNQLRELAALNGTLRDDEAQTCLNCGASGHRRYECPERQNITSTLSCHICGGMGHISRDCTQRNNPEFANQSHERDSQLDSEYMNLMAELGESVPDGANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0B4</accession>
    <name>A0A367K0B4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000449">
        <property type="protein sequence ID" value="RCH95608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0B4"/>
    <dbReference type="STRING" id="86630.A0A367K0B4"/>
    <dbReference type="OrthoDB" id="5560686at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="249"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="47274" checksum="CC353A9FE6E7B476" modified="2018-11-07" version="1">MTITENLETETKRTFVKRLVEEEEERGKIASSFKKLRPTEHPRWHNQSYMLFLALRQHPDHCLPRAQLINSALELDIKISAELGLPRVFRSKTPANSASASLTVNSDRYFIPFKPEGSKSTWFKLAYEPGDEGKAVQEYQKWMKKLIEHDWPYCFGIPKVIKQVPEDYQTPPSTDTEMKKESTPNEPEAVTMLTPVSDVTEPFKSETDNEEKRKSRKSPSLKTKVVHPPMPTYTLDELDLSDIPGSWKDIVYVAPSRIPGAGLGLFAKRKLPYNAPIGFYFGVPMTEDEFDSLKDRVGRSSEYSIMYRRTVLDATDESGQPVTDPENPRYCPFHFMNESDEKGANILFVEGVVVNQVICWTKRDIQPDEELFVWYGRDVDRHWDSRKKKRHGQTDKSKIATEDDGSELNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2F3</accession>
    <name>A0A367K2F3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000375">
        <property type="protein sequence ID" value="RCH96373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2F3"/>
    <dbReference type="OrthoDB" id="2156393at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="162" mass="18345" checksum="1F405382D96808C0" modified="2018-11-07" version="1">MRELDIEGQDILSKRILKNQKVIDLIVNSLLNIRAGTYGFASSEWRHNTRSDIHRSKKSLTGIPDVKKTESLIENGHTYNASGKRQLSNLCTDSESNLEFSEKLPVGTKRPPATPQITDEIVFVKRFKTNAGRMNWIRCLTDAHENNILIPYSAVNIHTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2S4</accession>
    <name>A0A367K2S4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000362">
        <property type="protein sequence ID" value="RCH96503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2S4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="131" mass="14671" checksum="E796C66E5C206D4E" modified="2018-11-07" version="1">MSSYTSRFTELDIYSSEFVLREVVTTNSSTQSSSIYCNPYFANSDPILQGKSSSSLAKHYLTIPENSRPIDFSADQRSTLPLPPLCSSSQPNSTEKHFQSLAKRFKRFLHSISTPRLKSSFSSSSSYSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K474</accession>
    <name>A0A367K474_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450-dit2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000316">
        <property type="protein sequence ID" value="RCH97014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K474"/>
    <dbReference type="STRING" id="86630.A0A367K474"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="59517" checksum="86B58806B31B6ADC" modified="2018-11-07" version="1">MGISGKYFAILSASVATVIAAVYVKRAMIRSHRRKLRLVHSQIPNPLNDEELQDKQLNTLPSKTITQWHQQYGPLFEINTSEYKWIFVSDLEAIEAIFIKRSVETSLHSYSAWRNIVNGGCGSGIFFNGGEGRWKYLKAALRDVLSPAFSDSVEGMSRMEIERCTRNLITQTGNHGSVNPSLCVRFAVVNIVLYIAFGKPFAESMNDDTFKRIESILQSYQKLAATSTVAEDKGCPWSFFLKCSPAKSKESKLIYRRQVQPLIQLLVKSARTDNNHNIVKQLDKMREDYHMKDDDIHKIMEEFVFISCRTLCASILWTYALLCHHPKAQTNISQEFIRFWKQNKHFPTFVDQSSFRYYTAFQKECFRYRPIFTFSAPRKITKDVYYDGLIIPKDSILLSSIHALHNDSARYPEPEKFVPERFLYDTNPMHKTSRNCLQSRDHFAFGWGSRACPGVYMVEKFLFDVVINLMSQCSVRPALTVEGDKLYPDIDNYIEAGVMAVPVDFKARFIERDSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4D7</accession>
    <name>A0A367K4D7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_005532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000315">
        <property type="protein sequence ID" value="RCH97019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4D7"/>
    <dbReference type="STRING" id="86630.A0A367K4D7"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="606"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1145" mass="129898" checksum="CF28E0097B4C0616" modified="2018-11-07" version="1">MIEEKVIVDKNNQQVVDTTAAKKAAKDKKKIKKEEADVQQEKKTKKPVKKKKNKDTADPAETKKNRSKLKKKSDDKKPTAVEHAAVLDGAESSVIVTALDYEEDVEGEIEVFDYHELEKALGGPVKLHDLPSIRFAPEAKKKKSKPIMQKSRSAPSESIASNHSAKNGKYSAVPPPQSLLSSEKPVKSQKVHARDHQEKKKKQDKEHESESVKPSASKKKTRQIKVEEVEFKVSTPSVKLPAKKEKGVSTDQKPRSTKSSGFTKRQLGEDVKPVVLAKKEGKNMTKSLNEEQKKELLTVDYCHPYDVLYGRKGRMRFERYLDPKICEKRAKEKETNLYKGILRINKRNRTDAYVTTDKLESDIFIFGPRDRNRALEGDTVFVELVDVDAVWAKKKDGMARKKDESDSVIVDEKSKPKYAGKVVCVQSVRKDRLFSGTISIQRASNGTNAAANGNAAEEETDIEAVNELVDDDEGQEAVEDSRSSNSDKEIEPKKGNHNVRVVWFKPLDKRAPLIMIPVKNAPYDILDNEAKYANLIVVVKITRWPIDSLNPIGAFVRELGHIGNIPAETEAILADNGILELPFSKKALSGLPPTPWSIEQSEIDKRRDLRTTRIFTIDPATAKDLDDAVHVTQLDKDSFEVGVHIADVSHFVKQHTALDHEAFDRGTSTYLCDRVIPMLPPLLCEELCSLNPGVDRLAFSVIWKMDSAGNVKETWFGKTIIRSCAKLAYDDAQSVIEGHGLPKAVVIRDDHKVSDVEQDILYLFEMSKKMRERRFANGALFINSIRLSFKLNDIGEPCEVSIYEQKDANRLIEEFMLRANMSVAEKIREHYPNEALLRQHSPPHEKSLNEFLRIVDSLGYKFDGSSAGSLQESFNSIESEDVKSVLKLLAVKPMQRAKYFCTGSFEDINRFRHYALNVPYYTHFTSPIRRFADIIVHRQLEAALANKKSCGYKKAAVQKAAGHCNERKEGAKNSQDMNLQLYLYHYLYNLEKETKKPVICTAIVTQVLKDAIDILVPEYGLEKRLHVDAIPIERYVFDGNKTTLSVYWKEGVDSSWEWDQKRRSDQDFVEPVGTQIELDDEQDNDDENNEVVTVKIPEELLEENTLDKETRMQTFKTFSKLNVRIQVNVERSPPIVNIYPTNPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K686</accession>
    <name>A0A367K686_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase</fullName>
            <ecNumber evidence="9">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPO14_6</name>
        <name evidence="13" type="ORF">CU097_014662</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01000257">
        <property type="protein sequence ID" value="RCH97687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K686"/>
    <dbReference type="STRING" id="86630.A0A367K686"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="222"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH97687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1179" mass="137396" checksum="1EE3D5CD8BECCAA9" modified="2018-11-07" version="1">MSNPIADTADYFTRYNKQQQYQQQFEELPRHIPERPWTRVLDRISFLIPPAYFHGDDDSVYDDRDTFELMKSKASSEDTTLDEAYSSSAAKSIIDIKPGEDEERLPSAADLSKAMTPEKEASDYFTHPFPEQQHQHQQENRRDISDYYRTVAPPEEGRIKDKWDRTIDKLKFIANLTSHQPVVVQPILGPSHTLATYYPPAFDPVFTAFARDEYGRKLPPILLQCIYATVTDSEYVDGINQWVFRVELQYGDVKWVIRRNIADFMALHFKLKVKSNLYDYVPDPPNFPNQLSNLLDTAKSTIGLFESKQTNYNRRATLTDYLRSLLLRAHVTASYDICEFLELSAISIAHDMGWKGKEGYLKNRIRYVAPKCFCISRITKRWTTEWIILRDSYMAFSKDAASSEPTDVLLFDSSLRFEVLEPRVYLGNYHIKIRNQSREIEIKGTKREIDQWIDSIEKVKSESPWVYHHRFASFAPIRHNAKVKWFVDAENHFNAVAEAILSAKVEIYIADWWLSPELYLRRPPEENEDFRLDRLLKRKAIEGVKIYIVVYKEMSLALTIDSVHTKQTLQNLHPNIIVQRHPDHSLGKNDTVLFWSHHEKIVVVDNRLAFIGGLDLCFGRYDTHAHSLSDFPAEGHDREVFPGQDYSNPRVKDFINVAQYDRTLVNRTTTPRMPWHDVTLGVVGPIARDISRHFIQRWNFLKTTKSMHRRAVPFLMPKGEYVAARDESKFSGTCKVQLLRSSSRWSSDIEREHSIYNAYMECITHAKHFIYIENQFFISTTTEDKLLRNKIAEALVSRIKRAHDKGEKFRVFIIMPLIPAFEGDLASSEAYSARNVMHFQYTTISRGGHSIMEKLREYGIDPDQYINWFSLRNYAKLKVPPRTENPFDDLNRVPTNQTSSSPPRRKSYPTIDDRYSYVTEILYIHSKLMIVDDRIVLMGSANINDRSQLGNRDSEVAMLVEDTEMVQSYMNGKEYQAAKFAHTLRMQLWKEHLGLLNFEKWSDLLKGTVEREVNELGISRHLTIYPSLARSRNNAEDIRQIEADEPVKMLDRASRTYSLYDTFKSHRHLKRHDAAVLDPLSDRFYTNIWMKRATTNTKVYRKLFRCVPDDTIHTYEQHRAFMPDDPGHVADPTLTEEDICQELEKIQGHIVLFPKDYLKDENLLAGSITNTVAPLVIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6G7</accession>
    <name>A0A367K6G7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitronate monooxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000243">
        <property type="protein sequence ID" value="RCH97852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6G7"/>
    <dbReference type="STRING" id="86630.A0A367K6G7"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8064" checksum="D56139A683262644" modified="2018-11-07" version="1">MIVAVEINKDISELVSGTRGKQVFVKGDPDLGIWTAGQVLGLIDDIPTCHQLVTRMIDKAEMIISQRLRNMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K732</accession>
    <name>A0A367K732_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2 6">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN5_1</name>
        <name evidence="9" type="ORF">CU097_004218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2 6"/>
    <dbReference type="EMBL" id="PJQL01000233">
        <property type="protein sequence ID" value="RCH97978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K732"/>
    <dbReference type="STRING" id="86630.A0A367K732"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="195"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH97978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="317" mass="35218" checksum="BC9FF79D83543C72" modified="2018-11-07" version="1">MTIHILGAGAIGCHVASVLRKYNHKVTLLLRSDLKVEEFNKHHNRITYRSRGNIEHISGVEAVKAKEGTERIMSLVVTTKSQHTLEAVSSVASQLSPSSTVLFLQNGMGVVDELLDSVWRATPPPSIIVGINRHAVERLAPYDIQHHSGYDAPESLVLAEHPASGKPLDQSLAQTIVGIPEFRATLLPWEQAYVKMIKKLLINSTINPVATILGCKNGGVLHPHAQTIMQSICEEAFELFKDDLPDETLDSIMKMILEMAYEAKENTCSTLQDIKNKRLTEIDYFNGYICKLGKQRGISTKMNEAMINLVHAKEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K771</accession>
    <name>A0A367K771_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000230">
        <property type="protein sequence ID" value="RCH98020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K771"/>
    <dbReference type="STRING" id="86630.A0A367K771"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="86" mass="9604" checksum="3CE83B97A144208B" modified="2018-11-07" version="1">MDSAEEVSKTIDSKNMNNDTTYTLLLTDLTVLHEMATVLNTGLDRKTVGYCISLCEKGANPEALATIIKDLQKQQENKKKETNNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K810</accession>
    <name>A0A367K810_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000210">
        <property type="protein sequence ID" value="RCH98269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K810"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="3">
        <location>
            <begin position="65"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="4">
        <location>
            <begin position="548"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="791" mass="90745" checksum="D9BD98F721BD9406" modified="2018-11-07" version="1">MPTFASYPSSLPYFAELHDEGLLSGLIAGLKGRRVRINKAPAKQGEAPNHPFMNYYDRLVNMAHTDNGAVIHASTLDSCVDLYYASDRLSNRHEKQKLYKDAWSADPELTLHIIFYMRSIHRGQRLIDGFMDAFCWLIQYHPRTALANLHVLIDGTIRTDAALMALRRRERKKAKAEREGWELMDDDKEEDLLERRDFKTHGYWKDLCTILTIYAQGEITGPVGSDDYKALKWPRMARSENRWNVWSIRRGRYNARKNMDPKTAKKEIERTLERVKEYNAKKQAEAKEKRHEIRKRRNDHVVYLLHEHKTYRALHFTIARLFANQLKTDMAQLQKNKAAVQENRLKGKYALGFNLSLAAKWAPSLGNCHDKHTFLATSIAELLFPPKSHQDPGESREHYLNKVRDLYRKQYLTPLREAIDLVEHYLKEGKWDQLDLGHVPAVCLQKNLALFFKHAPDMVTRYLDEVAKGKKKVSGETITPNSLVYRIYAGNTEQMSKVMAALPSARERLREAVLKLVNGQWNTLIEGLRNTSLLNTKDGLKERVDLGECMAICDVSGSMYTSGGKAEDTPLYAAIGLSLVIANLAKPPFNGALITFSQRPTLFHIDTSLPFSKQVYEIRNKMEAGFNTNLESVFLDVLLPMAIENKLKQEDMVKRLFIFTDMEFDENGPSYGIYEDSEAYRKRHETTYDSICHKYREAGYEPPEMVWWNLAGYASASLKNLDAPVTKDQVGVKMLSGLSASMVKTFLDGDDPADNNNRKDTLKKSSKEETPQDFVKRAVYHESFKGLIIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8B2</accession>
    <name>A0A367K8B2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000202">
        <property type="protein sequence ID" value="RCH98369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8B2"/>
    <dbReference type="STRING" id="86630.A0A367K8B2"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="245"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="404" mass="45279" checksum="CAE713AF1909B187" modified="2018-11-07" version="1">MATINVRRDVQDSFYRYKMPRIQAKVEGKGNGIKTVVVNMADIARALSRPPSYPTKYFGCELGAQVKCDDKNERYIVNGDHDASKLQDTLDGFINKFVLCQSCKNPETDILIKNDEILMDCKACGARNMADMRHKLSTYIIKNPPAVASKNVRRQRKAATAQTNNTGEDAAEAIDGSDEAADAGNGSDDDIISQRIQKQAAGLNMESKLALEDWSEDTSEAAVAQRMKELSIKRGGAFGGVDDDDEEVDNKYDAFGDWLESQKNLSDEDIIEKAKELGVYGKYKACLVLIQCIFDETVVSQIPKRAKLLSKFVTDEKHQKATLGGIERLIGLKHKDALLKKTPTILMKLYDLDIIEDEVFLKWGEKPSKRYLDRDISKEVKKAAKPFLEWLETAEEEDSDEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8N0</accession>
    <name>A0A367K8N0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000191">
        <property type="protein sequence ID" value="RCH98526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8N0"/>
    <dbReference type="STRING" id="86630.A0A367K8N0"/>
    <dbReference type="OrthoDB" id="2272101at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="385" mass="43291" checksum="EFD24C1CCCF531F5" modified="2018-11-07" version="1">MTIQVRSKRRILPKRSVIDIDFVSPKSNNLQDLLCTSTQIPSKKDYSVINELFGDQSKFPSQREHLPHIVLGIPKKSRLLQKQEDREKLVESQKIHENIPVKSNDQENQDEKHVVGQGVLEKTKGLSNGKRDVLGENVIKTSTSTSSVNSSTSTSSDSSNISTSSGSSSNSDSNTNSDSNVSDSSSGSSSSSGISEHNESTEDTIRSINHNNNRVNNDHKEHELIDDLSTSSSTINTSTSTSTVNTNTSDIISQVETICNDAASETLYNKQEEMKKRDSISEEPVVVIELTKRKKKLKVKELNPCERKESFMFPPKKEPKIKARHELLKTLKESGALDWIINGRDRDSRKKDIGKVRKRQLERRLQRPFVTRKLIHNKNGWLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9E7</accession>
    <name>A0A367K9E7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="2">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GLN1_3</name>
        <name evidence="12" type="ORF">CU097_008710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000169">
        <property type="protein sequence ID" value="RCH98808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9E7"/>
    <dbReference type="STRING" id="86630.A0A367K9E7"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="11">
        <location>
            <begin position="85"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH98808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="342" mass="38869" checksum="F7BF4EF9533BB185" modified="2018-11-07" version="1">MNDIKTQRIPIEYIFIDKQNELRSISKTLEFMPVQLSDIPLLYVDHDEQLVELIQKPTEPLIPVAMYEDPFRQQGAKLVLCQMPTRLQCKKIMDHYAHLEPWFGIEQEYVLFDPKTNKPLGWPRHGQPEKTGKYYCGIGTGKIFGRDIMEAHYRACLYAGITICGCNAEVVPGQLEYQIGPCEGVSIGDELWVARYIMERVAEDFGLMVSLHPKPIPGSWNPTGCHTNFSTNQMRSSEGGLDAIEEAIENMSDKHFEHINVYGQDNHLRLTGEYETGHISVFSYGVGNRGASIRIPIKVALDGKGYMEDRRPAANIDPYQVATIIMTSSFNYKPPSLFEIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9T9</accession>
    <name>A0A367K9T9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000154">
        <property type="protein sequence ID" value="RCH99003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9T9"/>
    <dbReference type="STRING" id="86630.A0A367K9T9"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="225"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="560" mass="63927" checksum="BBCF3CCF94435E03" modified="2018-11-07" version="1">METKIYRKLKKSTMKAIHLKMAYEVIDDQVIVHPKVILKQVKDYASMKDIRRLLFALFKMNKPTPFAELPEFSGVQPVGKVIFIDAPILDPHELGLPLEVPWVSKSDTPEVYDKIISSSIRDYINVEDDVIGLVTVVGFDQYKRVGDRFMDLLEVPLTKADVKKRREEEEKLPDGTLAIPPEMLVMTLEELKMEDFPIHSSLDSNSVLEDGWVETSPGKGAKVKRLVALDCEMCKTVNGYAITRVALIDRDHTILINEFVKPTEEVTDYITHISGVSEQSLVGVNTTLADIQKKLLTLIDGDTILVGHGLVNDLRCLRMKHPYIIDTSIIYHHKNGPPYKASLKDLVAKYLKRSIQVESVDGHDPCEDAIASLELVERKLQRGINYGLTGLSQVKTILDNLNSQEQEAAVIETNANLSVSMNRMLSEHLLKGYFPEANDEHVCKKLIELHPSKKFIFARLDLPQETEQDRQSTFHALFSNVYKHAEPYTVFCLSTGYRKNKQREELREKRLQYKKNLKKIGLEDIPMEERWSPEEELLLEQTSDSTRRGFVFIHVKGTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA06</accession>
    <name>A0A367KA06_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_004791</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000155">
        <property type="protein sequence ID" value="RCH98980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA06"/>
    <dbReference type="STRING" id="86630.A0A367KA06"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="11">
        <location>
            <begin position="406"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH98980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="604" mass="67446" checksum="63D8AAA029F1D9E4" modified="2018-11-07" version="1">MAEGGHNGQQQQQQQQQPQNLGPEDLNFSINDILNGNSVVNDSSFQTIVQTFSDTSNNQDMMPSFAHLPAELQDFFSSSETDDLLSTQNASLPHDLLFNADHTQPFVQQPLKIQTNPTGSPQPQQTTIPHALPQQQQLHQQQPPQQQLATHSPQPHALPPGPVPQVLAQPIQPSQPAVPSLPQQASSTTLLDNITSQLPPDRKEKFMQLFRDLQTSTISAAEFMAQAKAILGQQQYQQLEDLKTRPMINHQMQPQQEQQQQMMEEDQRKRKLNPASNISSPQIKKPKSEHIPMNAINQQMTYPMMTPPRVPTSQPPSILPQQQQQQYPIQPNIVTPSLVKPPTPAGPQQPQQQSPFKAMDAAVLQIPTKSNIAVPSTSKPPGTTAPTPTSTGGGGGGGDRVDYEALTDVMGYAGVDLKEEAEHFMKEDASGTVLPDGIDRSKFQDFMNPAMLRDRILKYAKSVNIKKIDGDFISYLALATQDRIRTVMENMVRASRHRTENPFKKPPEQDNHPLYKIHVKQKVKDQLKAIERAEESKGKMDEEMDDVLNSEKGWYSKKSRVPLKAESIERKITVQDAIFVMERDVQGGRGTNRRTLLKAYNILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA98</accession>
    <name>A0A367KA98_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000149">
        <property type="protein sequence ID" value="RCH99070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA98"/>
    <dbReference type="STRING" id="86630.A0A367KA98"/>
    <dbReference type="OrthoDB" id="2237019at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="135" mass="15804" checksum="F8A0B8B064BFC106" modified="2018-11-07" version="1">MFRLTGLDPGRNTVFTAAYGDDNGAYQVRRCTRKEYNTYSGSRRIAKEVDKRAEQERITEVLHNKPTEKTASTEQYSVHINYVLSNLSKYLEFYKSDTARTRFYLYQGRQRALEEMTNILVNGGKEYNHAKRKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAA5</accession>
    <name>A0A367KAA5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000145">
        <property type="protein sequence ID" value="RCH99118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAA5"/>
    <dbReference type="STRING" id="86630.A0A367KAA5"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="431" mass="46117" checksum="96D1F4D70C0ED75A" modified="2018-11-07" version="1">MKIQQQKQTAKYHPYVPLPRRFQLVIKAATYATSQNSRGAIPVFQLESNGHLILWDSENGLALGNSKTDIAKIIAENPNLHVKKVRGGCLAIQGTWMPFESAKELCMKNIWALRFDLVPLFGKSFPIDCCPPSHPGFGSLKVGSAPIPEDSQVSPGLATRSSRPSRGRASSASGGFSPYEKASTPRRSVRQKERSLSSASCPSASGGRGQLVSPADDGAACRTAGSVARVRASHAPRVSSGSPYLASSSPDSSTSSCASPSVLSRRRRHCMSTQSLLNDDEEEDCYLVVPSAFSWLGLPSSVRVTLPPMVISGFEGEKSGAFTYGSSGFLASLPTAKIIEKGMHRDGSDQQETSAAVAEIIPLFGPSSSVPSPLPVPARLTSQEQDVIERVEAGIALQCLSQHGGRCPKDFLKNRFLPIKVRAGNKIFHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAD0</accession>
    <name>A0A367KAD0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000145">
        <property type="protein sequence ID" value="RCH99117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAD0"/>
    <dbReference type="STRING" id="86630.A0A367KAD0"/>
    <dbReference type="OrthoDB" id="2288192at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="31026" checksum="EF06EFB64C5E37F3" modified="2018-11-07" version="1">MFHQNSFASGVGRGSLGNVINPYKKIIPGRGRGRCGETLDSEIDKLELDEYDNVNRGRVVKAYIKSVAENDQLLPSDVRCPKALVSTLDYLIDEILSKNPLKECHAFIRDRTRSIRQDFTLQNIRNEVAVEVHERIARFHILCLHEMRDLDESKFCVQQEIQQLQEACSRNRKHYRRLQIAMSSQQTSTGDSVVCFQEGDKPAVEITRCGPLRRPYESPSVKVCVLDDGSEFICDRRAIDPMEISHSESLLNPPWNLISRCLSKILQERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAN9</accession>
    <name>A0A367KAN9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000139">
        <property type="protein sequence ID" value="RCH99210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAN9"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="343"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="573" mass="66064" checksum="3B8CCFAF840CD064" modified="2018-11-07" version="1">MSNKPLDTTIKKAGPSKPSAIAKQVLKTTPIPQPVKSSSSTPSNVYATNYQTQDTPRGKATQPLRSTKVSQKLVLFPQSDDAEATMQATLPVDSTDHFAPQRRKSSASFERPWQPIDQPTTPTAAAGLPLPIEWTFDTRTPAERMTKDERDLAGLPRAAAYCTGEGYDLTRLRPFLREHHRAFPRLYDECLYAAYHFPLRTLRPGKDNLHNVRVQSNVPKVSVDSRQNTMDEEYMDYEEDHYRSEEPIVIQPREGDPYTDYFHRQKGMHYDQPEEQQPLIEHREKDDDTYEEPSAQDEENLYNDSTAHDDSSSNNRPDMDPENNKSNEDQTTKPRELFKGGEVFIFDYGVVVFWNFRRAEELLMLEDFMQFSIEPFRDNPDEDMQIEEIHFQYDTSQMKPRIFNDMITLKSSNHMIKLTLSHGLSQSAVVARYEDIMDKTIDETKHLPKEMAETGRLGKTRTEITKINGQLFNLRMNVNLVSNVLDTPEIFWSEPALEPMYTAIREYLEIPQRAKILNDRLRVISDLLSMLRDHLTNFGVEYQTLIIIYLIIVAVIVACFEIAVKILQSLNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB66</accession>
    <name>A0A367KB66_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory factor X, 4 (Influences HLA class II expression)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RFX4</name>
        <name evidence="4" type="ORF">CU097_014188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000127">
        <property type="protein sequence ID" value="RCH99380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB66"/>
    <dbReference type="STRING" id="86630.A0A367KB66"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="451" mass="51719" checksum="7F9807E4120C1EC1" modified="2018-11-07" version="1">MYEHYKAHCAARNLTPVNSATFGKLIRVVFPDLKTRRLGVRGQSKYHYCGIRVRASNEPNPTSDQILTITEDNSGSTRDNISTSPSAASSVHSTASNILDSSISIQLPPFMKPNILSYPHTNELDATIHSFISAYENHCRQILYLVTHHQVDKIQQVMALFYDRMPENFQLLIHEVPEITEAVWRYDSLFYDTIIERFLPTVNYPLSQAMMITLRTYTRELSNYIGAFVSRFPINFYQKKLDVARIFAAKFRRHLSLNHAAQTATAVLNMPEYLSAMRKDWEQLDFDGLLDQTLWVCDCNTTDIRHILNQEIYDLLTVKISLDHWMNWVSSIVDSYLKKFTPSSSNDASHYLAQAKQFLLKWNFYTSLIMKGLARQNARSFSSFHTIHLFLDDYALYLVEETIAQANYILMRQQQVIQQTESSSTATTSTSATRTNIYSSPSSSTSKGNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBH0</accession>
    <name>A0A367KBH0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_011377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000112">
        <property type="protein sequence ID" value="RCH99593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBH0"/>
    <dbReference type="STRING" id="86630.A0A367KBH0"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225:SF19">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="366" mass="41660" checksum="8DEF77073A21034E" modified="2018-11-07" version="1">MLLILLEVQRRLQEEYDHIGFSMTLVAIQVIASILVLLASWEMYCDKPLRVFVSVYIVRLVITAPITIYLHLTPRRRSTRITSSPRTSARSELSEAYALSERNRPVSVPPPVTTNNNHRHYPPFVAPAQYSLMADTTSQQMNSNTFRICVDRAKSALDVFAVLWFIIGNYMLFSSTTCSDTAIPLYYLSLCIIIYGYLILSVPIFLCTSVIFCLPFGMRLLHVDDGVYMGGATSEEIAMIPVYRFKSNNSTSSSSSSLPEDMITIDLSKVHPYQEKKSSLLDKLWLYLGLIDPPCEKEIELELLEIPDTQDQICVICLSTYEDGDILCKLWCKHHFHKACLHEWLALNFRCPMCKQDSRGKDVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD90</accession>
    <name>A0A367KD90_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RKI1_4</name>
        <name evidence="9" type="ORF">CU097_015392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000077">
        <property type="protein sequence ID" value="RCI00158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD90"/>
    <dbReference type="STRING" id="86630.A0A367KD90"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000018">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="268" mass="29685" checksum="80D984024C02F95D" modified="2018-11-07" version="1">MTFLSIQARRTIRAHFHFLKKRQVSTESVEQGKRWAAIKAIRHVIDSQPSVIGLGSGTTIVYAIDELKKHKIAQDVVCIPTSFQTRQLILANNLKLGSLEQYPRIDVTVDGADEIDPKLNAIKGGGACLFQERLVAKASRRFVLVADERKRSSQLGTKWKRGVPVEVVPMALSPIQYTLEEMFPDALIRLRISQSSDKAGPVVTDNGNFILDCHFGPIQNPDLLYKEIKSLTGVLDVGLFCNMADTAYIGHLESDSGDVLSVSDLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDB5</accession>
    <name>A0A367KDB5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA polymerase III transcription initiation factor complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TFC3_3</name>
        <name evidence="11" type="ORF">CU097_008183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000074">
        <property type="protein sequence ID" value="RCI00205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KDB5"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056020">
        <property type="entry name" value="DUF7599"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24538">
        <property type="entry name" value="DUF7599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="8">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7599" evidence="10">
        <location>
            <begin position="270"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="9">
        <location>
            <begin position="1436"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI00205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2052" mass="235481" checksum="16D2E23B0A6704D1" modified="2018-11-07" version="1">MLDIVLSRLKEEIAIDGPSGSSSDDLWNYVQTILTDIAKESSVDNVNPTIDDNYKAFIWNHLKQEEDLDFYENLDLMETDKQEEQQTASSSNRTDQPSKRKAPAKQKKAKKAKKDKKLNLKPIDDARNMSYEEIKAYGGSLRIVAAPKLQEEQIYVGIPPGNKLSPNLQVVLKLVVRTRHKGFYQSDLSRVYGVDSRSAGHYFKSLEQKGCIIRKGISLKGARTNICVHARFVAEDKSIDMSKAVQDESRQYYNVNINNEAFSLVQLRDALVDMIKDAPGQAILSKDVLEALGFNRENPAVQKWFNRSLDALFLQGYIKKTNVKLDNRGKYYRCLHLVKMPEDKNTVQVQATVEDIVFPIRIKSTRKDVPILHLLHDTCIESQCYQVIEAADTQGVIAREIGFALNLDEQRLLYRVLEKMLEISELNKGYGSICRHLEFEGRQRRYRYFTYPAYLKNYENQDANLPPLPEVPYNNLKCEEEDPFKDPVYTVNAAFKISTKKRATKSKESTAVKGTASKRHPRKQQQKKQQQEPAPQPVQESTPQPVQESAPQPIHESVHKSVQESIHQPIHEPIHEPIHEPIHEPMHQSMHQPVHQPMHQPVYQPVHQPVHQPMHQPMHQPMHSQVYYPTYPPAYHPGYASGYHATHPMQQPVPHPETRFVFEHPNKQQSPSGAPKKKRQAGIMEFFNTSKKRDRQPEDTPITNPEPKKLKAEAVNESSESSSESSDLLSPVIIIPESPILKAATSTPTSNEGTPNPISIADDITSTPAESTPDPISIIDSMASTPAESSTPTPVIATSISIESASTVAMDDNNIASTSSENVVVTSLPNDEVPALLKAVTSRTSRKPRRETTVAILKSNIRTFNHNKPSRNSYMEQRAIVLRALLDEMHMIEYSKNFRDLYQERLRKEFGTTSHAHTICMKTLKRTIDQLVQKGDIKDAIVRCEMMNGKFVERRVIMKKDIDTSSSEYNDFMKAIRDRHAVHRSAFYITKYERLSIPIERTAQRITRMKEKLQELNDSGDVTGAADLEKRIKQLEANYERCKTDDNPKIPKNWLFTAIQFNYIYPSMLRAKRLHQHLFSLICSSEDIEGINKEDGIITASALVRNMSVEVYCQSIGVTEVDDVIKEYFRNTKDLSIPCSQLPSQVRKRMFTHQNRFRQKLLYVLNILEFIHVVTPIRPTNVNKNPLNDIYYTTALAHKYVIERKVDIREIRRAERPVVQSYTFTSQEDLATYWSDLECLYRSQQDIPKDEIVKPFNNENERIAYTCLTGNKSWKISTIYNSSQRKILNSYVDKSKGTTPLDNDGLILNIAEEIGSQAHFVRLYYKRVQEVLDDKMEARTIRKIEGGNRKRRKGQHKIDMFGGRRVVRLSDKTLFKSQRQYHKNLRKIYPDAEQDEEPDGTKQSGDEASFMDSLSSLPVLKQGDTRPLVQIRMSKIPWSAHEDELLMYTTAILRLRSNRRYNRFKWAAATQVINKPPINCLRRYGTLSRDPSFNLQVLNYMELWRKFYNEGIANGDIVDENPREMVNFDLLGQVTYFLQRLSEMNENMPKEFVLPNSSEDLHSHYRILPSIKPYNYYFEQDYYRVTTMAAKINILGNHAFCVRRARDVEFDAPASLLRNEECRSVRLGYLYRCIALMSLLTPSERFDPFYSFKLLQVFPQEISNSVLEALHKSNTLIRSPQHDRTVPGTRYALSAKFMIRLSSSYPEGIYAQAREYEKFLNQQDQKIPVPPVLMSSGMAACILNLLSQEKLVLDIHRRKTIIEKAAMAIPRSRLMDTTPIDFSVEVEKTTKIDNESIPLDKVVQENAHIENLTIDEFEAKFDALLGTVDAFNQQLLKEIVDILKAKAEQGTVIHEIKEQLGGRYDDEDIIAAVDRLTLHTPPLICQVGSVYPRCVLVPYASDWVIDANVANTAGNERVGSKLARRSYKDLARKQLIVPNLWTDINGSLTPVLFNSYAEAIVEFILKRPGTTKAAIHRNFSTSFSRKEIHDILEILVKSKVLRELKIIMNGYKKPSVFTKTRYSRCTTKTNEIDAFAQSCYWATDDYYHKIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE13</accession>
    <name>A0A367KE13_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000065">
        <property type="protein sequence ID" value="RCI00350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE13"/>
    <dbReference type="STRING" id="86630.A0A367KE13"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016875394" evidence="7">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI00350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="427" mass="45544" checksum="799E5C076C254552" modified="2018-11-07" version="1">MTRLSQSAIILATLCASALAAVEPGCDKSLKVLNQLDLDGIKHCKDFQGTITIENMGPAASLNMEGVEHLMGDLLMSGNLELGAFSAPNLKTVDGQVKIENHTILSKVDFPQLTEVKGLTFSVLPALETINFPAGLTKVSNMRIEDTRAPKVDGFKPEIIGNFVLTNNNYMKSFDFSSVKQADELLIVGNNHDMIFDAPNLGTIRTATIINLAQIQLPALATIHSDISFHENEFSSLHMDSLQTIGGTFTIANNNKLTETSFKNLSLINGALSIGNNTQLLAVDGFPSLAAIHGTCDLAGNFEQYKLPSLQDIRGGMRIQTTSSKLTCADLERVLKGGNIVKGTTWSCAASMQEDQMVPTVGQNPANSNGNTAKINLGKDDPKTTKGNKNGNQINQKENASTTSAASTAGHTSLGFVAVAALAYFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE73</accession>
    <name>A0A367KE73_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000062">
        <property type="protein sequence ID" value="RCI00410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE73"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="12021" checksum="82B7A1CC9CCC9881" modified="2018-11-07" version="1">MKDTNNNSNQSINTQLEDSQLSADDAGTFVFDSQLTSDSSTIQLGNYNIKSQDDLFHSRVMADSGYISEKPNAKNDQHDTEEDPYRWVILFSGFLAQVISMCTLSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KED3</accession>
    <name>A0A367KED3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-CoA oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_000872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000074">
        <property type="protein sequence ID" value="RCI00202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KED3"/>
    <dbReference type="STRING" id="86630.A0A367KED3"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="10">
        <location>
            <begin position="34"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI00202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="25851" checksum="83E1F38F03E8B3C3" modified="2018-11-07" version="1" fragment="single">AEPSEHNHTINYLTQYLQNPNAKCPASKPSDFLNPELILSAFGYRAAYGIAKVAEKIDYEGRSWNSMLVEINRISRAHCQYILVRNFIVTLQNDVTLTQPEYKPINNVLKTLAALFSLNTMEKELSEFLLSGYLSSEQCSMLKEQVISLLHAVRPDAVGLVDAFALPDYYLHSALGRYDGRVYETMTKMAELEPLNQTLVVDGYEENIKPFVHQRKVVNKDTATTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF44</accession>
    <name>A0A367KF44_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenotropic and polytropic retrovirus receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">XPR1</name>
        <name evidence="10" type="ORF">CU097_015620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000043">
        <property type="protein sequence ID" value="RCI00740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF44"/>
    <dbReference type="STRING" id="86630.A0A367KF44"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="495"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="784" mass="91979" checksum="330EEAF7A0BFF22A" modified="2018-11-07" version="1">MKFSKYLESQSVPEWRKAYIYYKGLKKKLKQVERFRKSKERRAAAYIDQYFQNIDQTPSHKLGSGICNSPSFIYYFDRSTSRPASIKTSRTSISILDEVLYHASSSERQFFDSLDYELDKISRFYNEKEQEAKLKLDVLKVQVQFIAEFGRQLLDLGPTQLLSRQVEDGRSHGFKYQDQSYTLFPNGEQRISYTVARNRLKKAITEYYRSLEFLKSYRELNETGFQKILKKFDKIAGWKASTLYMKVVRKQHWITSTELNRIINETETLYINEFADGHRRRGMSKLRAPETNKEYTSTTLRVGILLGMAITLFIQAIQIAADPSIWIQLPNIYINMQIYACFLLPVLFCLGFSVNLIIWHRARINYKFIFELNPRQNLDYHQFAELPSFLLFISAFIIYSDFSQLAYPTVPSELYPLILFIAYMVIMLCPFNMFYLSARRWLGTTLVRIVLSYFFAVEFRDFFIADELNSLAYSIWTSSYFFCAYSEHWSNLEETCNVPQYWISPILASLPPWWRLLQCFRRYKDSNEKVHLLNAAKYTSSILAALVSGARRIYPSRGMNILWVCVCIVNSCYTTIWDIKMDWGLFMPNSKHFLLRDELVFSRWTYYVAISINILLRFSWTISTWGLPLSSQLLAFLIALLEGYRRIQWNVFRLENEHLNNCGQYRAIKEIPLPFALCETNVDQDPLERVSLKSAEPIPIARHPSYHTIRQSYDVGSFYGRRDFENKRDEDVPVGSVNSLCRKPSTLEHVLTHIRSLRGSLQGSDNSDDDEDDSEDGRDGEHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFA9</accession>
    <name>A0A367KFA9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000056">
        <property type="protein sequence ID" value="RCI00512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFA9"/>
    <dbReference type="OrthoDB" id="2289523at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="165" mass="19429" checksum="A350266E73BB1E09" modified="2018-11-07" version="1">MSLASEHQDIIQFSNRKSSYPMTSNFISHFASWAKFWLTVNDKTIPHKRKLFHRSEHKTPHVSVENNSIIPVTQRAHLYRATCHKLRPNQSNSKKSFTLGDILHIRKFWENLENLIYQNERDYIPSVKRIPFNPDIPGSVYLPKKSRKQIVTNKNRQPYACSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFF1</accession>
    <name>A0A367KFF1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000037">
        <property type="protein sequence ID" value="RCI00850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFF1"/>
    <dbReference type="STRING" id="86630.A0A367KFF1"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="2">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="144" mass="17213" checksum="0D02BD046B132816" modified="2018-11-07" version="1">MSTADEDYFAIDSNRIPKNNKALPSDLMTPFSTSSEDQTRSLYSRRRFIPNRWTTPSIKSIRTAKLKRMRLLIKQPHLPEFETQTFCENCEKYIQTRVRYRNGSLVWLLFFMLLLCTVILCWVPFYVKCSTLLSWLWKEDWDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGT3</accession>
    <name>A0A367KGT3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_015516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000010">
        <property type="protein sequence ID" value="RCI01435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGT3"/>
    <dbReference type="STRING" id="86630.A0A367KGT3"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="48"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI01435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="444" mass="48377" checksum="02E7A2F93CEDC069" modified="2018-11-07" version="1">MGNQEIEKYTTTPSSVHSYTESIKIEERAIDTYDEDNQSTVNEFGHGTGNFMTAFFNVTCVVAGTGTLGLPHAFALGGWLGILIMMLAYAMSVYSGTVLIRCLYYKPGQRLHDYKAVGTAAFGWYGKTAAAVLHFLNLFGCPALYLVLAASNLHYLLANTSAALTTTKWACIVGAVLLVPSLIAKTLKEVTALSALGAICTMIAVFVVVVEAPMDHHAHPERVVITDSVIWTGFPSSLATIAFSYGGINTYPHVEHALKKPHQWKWAVFAGMTACTALYMLTAIPGYWAYGRDTVSPVYNSLPNGPGRMTAVIVMTIHVILAIPIYTTSFSLEMEKWGNITDERVGKLKAWIARAVIRTACMAVLVILAIFVPFFDDFMSLIGALSNCGLVFLLPVLCYLKLTGVRNKPWYELAFCALTLLLGVVGCIFGTIDAIKALVHDFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH02</accession>
    <name>A0A367KH02_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000007">
        <property type="protein sequence ID" value="RCI01505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH02"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="9883" checksum="7D416974BC804159" modified="2018-11-07" version="1">MLMVQKRRRACCFYQNHESPGWRLPYNILGTGPQEEHLFQTFQHDGGDSEHEDQMRHVASALGLIRTNTVANTAGVTVNAWFIALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL89</accession>
    <name>A0A367IL89_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005159">
        <property type="protein sequence ID" value="RCH78447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL89"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="58" mass="6397" checksum="52CBA3E5A9A74B40" modified="2018-11-07" version="1" fragment="single">MDTYISEAPIEKSKNKTVSRISRLFQKKPKHKSSIPSSVSSLSISDPSLSKQASFQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INR6</accession>
    <name>A0A367INR6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004582">
        <property type="protein sequence ID" value="RCH79302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INR6"/>
    <dbReference type="STRING" id="86630.A0A367INR6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="315" mass="30898" checksum="B86036B4527594FB" modified="2018-11-07" version="1" fragment="single">TTAPSASSGAFNNTTSTAAPTSTSTTQTTGAFSFGSSTAKPSTTTTSGFTFGKVSEPASSTAAPAFAFSKPAEAPPAASTSAFSFGKSVEAPKTNPAPSFSFVKPAETAQVSQAVSTTGTASTTVTAPATTTSSSPFTFGGLGSTSKSSTTPATTSFTFGTSTSTTSATTTTTATTAATTASSSAAPVFSFGATASTSKPAPSLTFATTSSSAPTFSFGASTTTTEKKDDKGSTPIVTSNPFTFGTTAPTSTSSSSTTPGITTSAPTTTTTISQPVVAKPNPFSFTKVLDDLSKISTQPPGQIYASLVTPSLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPA2</accession>
    <name>A0A367IPA2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthetase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ASNSD1_1</name>
        <name evidence="5" type="ORF">CU097_001610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004443">
        <property type="protein sequence ID" value="RCH79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPA2"/>
    <dbReference type="STRING" id="86630.A0A367IPA2"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="221" mass="24899" checksum="C0314B103E7D54A6" modified="2018-11-07" version="1" fragment="single">PDSQQLKTIHIDNFGLQFYSTVLHLRGSNVVPQPIEESGNILCWNGEIFGGIYVEHGQNDTQVLMSHLAKADSQEDILSIFSRIEGPYAFVFWQAATKKLWFGRDCLGRRSLLIHRQSDLLLLSSVGLVNEAWEELAANGIYCVDMTKEGPDNIQLFPWSQTDLPLLPFPRLNAALPQHLKTVDNPQIAPVLDEQQEEIVVDFIRVLSDSVKSRVADIPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPP8</accession>
    <name>A0A367IPP8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004394">
        <property type="protein sequence ID" value="RCH79609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPP8"/>
    <dbReference type="STRING" id="86630.A0A367IPP8"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH79609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18339" checksum="299B8FEBB6D93A39" modified="2018-11-07" version="1">MPHSFGLRARTRHMFSRNFREHGTIPLSTYLKTYKVGDIVDIKANAAVQKGMPHKFYHGRTGVIYNVTKSSVGVIVYKVVGSRYMEKRVNVRVEHIKHSKCRQEFLDRVKLNAQKKKEAKAAGVTFNLKRIPAQPREARHVSTKKNVPQTIAPIPYETLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQB4</accession>
    <name>A0A367IQB4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase-phosphatase E1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004224">
        <property type="protein sequence ID" value="RCH79890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQB4"/>
    <dbReference type="STRING" id="86630.A0A367IQB4"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH79890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24448" checksum="BCE30B8C714FE56C" modified="2018-11-07" version="1" fragment="single">MSNYDTVVLDIEGTITPITFVHETLFPYVTSGLKAFLDRVWDSPELKDQIELLRKQAKQDVDNKLSEAKLIPTEAEASPEEIKSSVIENINWQMKADRKIGALKSFQGYMWKEGYESGELRGVIYDDVLPRLDQWIAEGKKIYIYSSGSVPAQKLLVGFSTKGDLSKYFSGYFDTKIGLKIEPESYKKIAQEINKECSSILFVSDNIKEIVAANEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR35</accession>
    <name>A0A367IR35_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004185">
        <property type="protein sequence ID" value="RCH79951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR35"/>
    <dbReference type="STRING" id="86630.A0A367IR35"/>
    <dbReference type="OrthoDB" id="19729at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="8841" checksum="3E8B3D49BB192605" modified="2018-11-07" version="1">MSVQQGTRVTYDRSTLLALAGSPFAKLPPVKMAFIPGVTRTPNQSDVVTSFRKEKDRKKEKEKEKKRFNPFALLGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRE6</accession>
    <name>A0A367IRE6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase D</fullName>
            <ecNumber evidence="1">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_001379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01004119">
        <property type="protein sequence ID" value="RCH80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRE6"/>
    <dbReference type="STRING" id="86630.A0A367IRE6"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="427" mass="49008" checksum="26255DEB11BBEF6F" modified="2018-11-07" version="1" fragment="single">DFDHVKDWDMRLIDKTVIPRMPWHDMSLCVMGAPVLDVARHFCERWNFIKHEKAKDKDNIPFLQPPLGGMGSQQRYIEEDSETHHYRKYRHNHRTHGVTGTMRTQVLRSSAKWSSGVELEHSIQNAYIATILEAQHYIYIENQFFITATEMNDGSILKNQIGNAIVKRIIRAHEEQEKFKVFVLMPLMPAFPADLSTKDAATARLVMHYQYISICRGPNSIVEKLKATGIDPDEYIRFYSLRSYDRINRSKLEELLVKAAGYGNTTQQQLDNIEGHEGEEAEVVHHAGDPDFARDTDGSFNVDEEVEYGRIPDDDDIRRHREQLEEGIASDSIAKDAMEGGDIESEPWVNDTKYSQPRDDEAEREEASDYVTEELYIHAKLLIADDKVVIMGSANLNDRSQCGDRDSEIALIVEDKDTIPSKMNGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRI6</accession>
    <name>A0A367IRI6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004013">
        <property type="protein sequence ID" value="RCH80256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRI6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="62" mass="7165" checksum="E4F6C64B9825929A" modified="2018-11-07" version="1" fragment="single">LKVNFFQLVNPNGYVCVMNKKIEYCCYPVHAKEFTKKIKQICVNKLAEEARLDMVLTAEPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVG0</accession>
    <name>A0A367IVG0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003328">
        <property type="protein sequence ID" value="RCH81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVG0"/>
    <dbReference type="STRING" id="86630.A0A367IVG0"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="214" mass="24632" checksum="A919CBDB15EB3AB1" modified="2018-11-07" version="1" fragment="single">TATMAPTKATTNESKQEQPAFKFTPITFEKKEPAKKETSISDQAKLDAQKKLERMKRFGVKLSEEEMKQIRAARFGTLNEQKKQDVTTKTTKKAEQGKVTKKRTPIKKNLSTLNKKPINIGRIVDKLNKTQLGKTQKKNDARTIIFDNGKRNKDMKKTADHTMHGRIVTIDNATPNRTVKIQKNKHASPFVNKKRNVFIQQENAQNLKFKRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVS4</accession>
    <name>A0A367IVS4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003267">
        <property type="protein sequence ID" value="RCH81815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVS4"/>
    <dbReference type="STRING" id="86630.A0A367IVS4"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="9156" checksum="DE0522FC7B98CDE8" modified="2018-11-07" version="1" fragment="single">MLEFQRQILTEIVSEDGLLIMSPGLGLFEILCNLIQIYTGGNHFVLVVNISQDEHELIQRQLVAKGVPYEQTIKHIEYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY70</accession>
    <name>A0A367IY70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FUM1</name>
        <name evidence="5" type="ORF">CU097_001437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002947">
        <property type="protein sequence ID" value="RCH82634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY70"/>
    <dbReference type="STRING" id="86630.A0A367IY70"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="434" mass="46973" checksum="4C4C217BA447FAB2" modified="2018-11-07" version="1" fragment="single">MLRSSVFRMMSQTTNLNHSTRLFSSASAVLQKFRTERDTFGDLQVPADRYWGAQTQRSLQNFDIGGPGERMPEPLIRAFGVLKKAAATVNMTYGLDPKIGEAIQKAADEVIDGSLIDHFPLVVWQTGSGTQTNMNVNEVISNRAIELLGGELGTKTPVHPNDHVNMSQSSNDTFPTAMHVAAVVEIYHRLIPALTTLRDALQAKSDEFKDIIKIGRTHLQDATPLTLGQEFSGYTQQLTYGIARVESTLERLYNLAQGGTAVGTGLNTKKGFDVKVADTIAKITGLPFKTAPNKFEALAAHDAIVEAHGALNTVACSLMKIANDIRYLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAMTMVCSQVMGNNTAVSVAGSNGQFELNVFKPVMIKNLLQSVRLLSDASVSFTKNCVVGIKANEKRIESIMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYB0</accession>
    <name>A0A367IYB0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002934">
        <property type="protein sequence ID" value="RCH82668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYB0"/>
    <dbReference type="OrthoDB" id="10292687at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="37470" checksum="57665D4213088572" modified="2018-11-07" version="1">MPKVENAKHVAKSNPTISSVPIVSTEFVAQPVCSTDLFDDHINSSTNYGTAIEHTYRGEDEDLLVFDDVEDNIEVWDNNRLQQVSSDEAEKVLYFSVDALMRESNDDTIEPSCSKQIELGHGFILELIDSSDDEEEKKCGHDDILHEIDDQQYADASNDGCSSGTCEYSITIEFDEENEFNSQPSWLLEDILNSAFMIKYTKGEMLKIQANVESYYHKDGLAAGSLIYGLIAKGKEEAKVARPKWNSNYQPRRRGYEDTERYDESDEVNTAKAIVPCVPIRQPKNPDNDGQQAGVYCDADGKDKNTEQNNDLYINCSICKHVVCLDCKQYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYJ2</accession>
    <name>A0A367IYJ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Secretory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SEC63_1</name>
        <name evidence="12" type="ORF">CU097_003855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002902">
        <property type="protein sequence ID" value="RCH82763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYJ2"/>
    <dbReference type="STRING" id="86630.A0A367IYJ2"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH82763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="662" mass="75375" checksum="B23314C5EE04A21A" modified="2018-11-07" version="1">MAQYAYDEEGFNFYYFLIAVLSLCLVPTTIQSLHALYKSASTKHKDVCHCQICEKGRKKANNVKSSSIKKLLTSPKFLFLVIGWVGVVLLAMQVANAEVKSVTWDPYEVMGLKESATEAEIKKAYKKLSLVYHPDKAKPGKEKENEERFIDITKAYKVLTNEEARRNYAEFGHPDGKQSFTMGVALPKKLVEGNGMYVLGFYALAFGLGLPYFIARWWYRSRRLTKDKILNKTMGVFVKGLKEEDGFKEIIYTLSGAIEYKEAVDVRPNEDRMLNIINGAIADEMEKKLGEKFDRLNDSVPAYRRKARALIYAYLLRVDLEKKGVNKQLIKDQSFVVDKAIHLIQGLMQIATVKQWLNVTCHLMELQQHLMQATFPGEPSIKQLPHVTTTLVRRYNRGRKTKIQTVQQFCDMPNDERKNMLKTLSDSEYLDAVEVAQRIPKLNVEKAVFRVIGDRIVTTGAIITFVLKLRNGQVVDVDTETKEKQEHDDEDEEEELLEDKKKNKKTLPSAHTPYYAGEKKPCWWIFLGDPKVNRILVPHKKVTDIVDEETIKIPFPGPPKPGVYTFSFFIKSDTYVGTDIVRDITLKVHDPSDLPPEEEVDDSISEPEEDSIAGQMKLMREQGFASALAGGSTKKPQNDDSDSDSSSEEDDNNYVTESDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYX2</accession>
    <name>A0A367IYX2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002854">
        <property type="protein sequence ID" value="RCH82895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYX2"/>
    <dbReference type="STRING" id="86630.A0A367IYX2"/>
    <dbReference type="OrthoDB" id="2250755at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="374" mass="42919" checksum="2ED8B92DD73894B9" modified="2018-11-07" version="1">MLKMNHGLNDVEQLFIRVSCTRFSSSTEGIEVCRQVYGEQGFKTQHVKVADNNIHIYCSRESGNIHNSKKRPFKEELKLLLYKNNQHDIYWRIQMICPNTDWPQMIKERINQLVQQKMQANEIRETIKSKEFPGIFWDDRSLEGYILKRTRQDQVTERVQKLIMASSRLCSVAATSEEWTSNVERDLYKLISHFTKILGIPVELLESMIDISVDDIYSDIEKTPNRGNKRQDTMEVKMHQSREEHPSIQIVSIPKHALFVKDQSSRSSMMISHSQHHEKIESNTYSNHGMFDLAAAAATTTTTTTTPTVAAVSTSSSSVPVTTVPSVRGYNQPFSSMYDYSFASSMMMRPHMNLMSQMPKRMPHSHSGNGSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ92</accession>
    <name>A0A367IZ92_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Guanylyl cyclase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GUCD1</name>
        <name evidence="1" type="ORF">CU097_003078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002851">
        <property type="protein sequence ID" value="RCH82909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ92"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="28062" checksum="0D377784C02AEBC5" modified="2018-11-07" version="1">MISLGDEAISINEALSNYDQVSDCPIPHIQQASNWDCGLACVAMILQGLGFDCNVEEIARECSVNSVWTIDLAFILKNYVQDFTYYTSYLGSRKEYQEQKFYQEDFNQDEKRINKLFAIAKSCSVHVVRMILPLDDYKRFLYCKQYATITLVNARLLKCKLCQQTRGCLGSICGQLDLFLEKFKGYDYLGHFILLIGYDPTEDTFIYRDPAIKDEFCVISADDLNEARQSEGTDHDCIVIKLTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZY0</accession>
    <name>A0A367IZY0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002729">
        <property type="protein sequence ID" value="RCH83237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZY0"/>
    <dbReference type="STRING" id="86630.A0A367IZY0"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="19845" checksum="CDA981AD3D523C09" modified="2018-11-07" version="1" fragment="single">MDFFSRGYIALRGERGQPQSADETIEKLADCLETATLLEDRRAAVLSLKGLVRDWPEEVGNKSFPGLIKVLHIDYKDTDITKSLLETISILCTVHNQYDKDDRGFKFTDYFIEESRNVTILLDILEEFDFYVRYNTIKLLSTLLSNRSKRIQECVLTNPMGISRLVDLLDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J017</accession>
    <name>A0A367J017_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002788">
        <property type="protein sequence ID" value="RCH83061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J017"/>
    <dbReference type="OrthoDB" id="10496640at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="22767" checksum="5F70D97029630BF2" modified="2018-11-07" version="1">MIRSVYRNACDSPVEIKAKQDFTKGFKDIPSSPISPEEYAEYMTPASSKKKKQAKANTSSDIKNTSVPKLKERMIEHPEVLKIKAERTIEPPESLTAKRKERAFELSEAAKSRQSQRSINSSSESNLPKQKKSVELASELTSPEQDQASALISPKREEEPTTEAKIPDQKGKTDESVSESVMVNMFRDILQKVESEYGLSKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1G4</accession>
    <name>A0A367J1G4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002554">
        <property type="protein sequence ID" value="RCH83788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1G4"/>
    <dbReference type="STRING" id="86630.A0A367J1G4"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF48">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="365" mass="41785" checksum="44B3344B7FC26008" modified="2018-11-07" version="1">MPPFNQYATVNLTQHEREKLTQDMIAKASNLVSRAFPDIQTTIMGASLNKEQVQQFRSLVECWTSSGKWVKMDGPVKVMPHFQDPLYAKCDRKYKGEGQRDAVRYVWQSTCEPVKNNMDHSVNRDRWCKVLNGRHILVVGDLVQYQLHEIFLNTFRDGPTVCFGELNCREHTLCNEPYQETHLKYLRNDRLSNNQHTNINQGYPTVDIIEMPFAKPSFGRGYPIFILNRSPVHETDEEFMKGLIETMKTIRKNNPNTLVIYRSSSIGHPFCDDAEGPIEGLTDSDYKVLPFGWSETKRRNLIAKTIIEGAGGVYVDLGALTDLRPDGHVGGQDCLRYCIPGPLDSWMHILYQVFLALDGKIPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2D3</accession>
    <name>A0A367J2D3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002467">
        <property type="protein sequence ID" value="RCH84085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2D3"/>
    <dbReference type="OrthoDB" id="2209929at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7599" checksum="5695DB09538D6CF2" modified="2018-11-07" version="1" fragment="single">PTGINARTAQNYVKVYNNDPQRRLSGTYYKPRGRPCTKLSGKHSKFLIDYIEKRSSAVLDELKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4E9</accession>
    <name>A0A367J4E9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002251">
        <property type="protein sequence ID" value="RCH84844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4E9"/>
    <dbReference type="STRING" id="86630.A0A367J4E9"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="124" mass="14312" checksum="CCF82A0A4A53F9C4" modified="2018-11-07" version="1">MSSAVFGVANLAVTTASAKSSNEARSRAIALYRKFQKSVPDMMKIHELNLPTSAVRAKIREEFERHRFVENLQVCDILYAKGEMEYQEIMNVWKQTNHIMNYFAKEEAPAKPTTFLEKFYEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J589</accession>
    <name>A0A367J589_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002192">
        <property type="protein sequence ID" value="RCH85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J589"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="51" mass="5687" checksum="459B9639FDBAC3D5" modified="2018-11-07" version="1" fragment="single">CGSAWTQQKCGFYQCGESTEDVLLRDNESKAELGVPDMHAIDARRQSIQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5V1</accession>
    <name>A0A367J5V1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002133">
        <property type="protein sequence ID" value="RCH85300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5V1"/>
    <dbReference type="STRING" id="86630.A0A367J5V1"/>
    <dbReference type="OrthoDB" id="2291042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="611" mass="69627" checksum="C43B4DD588D5C9E0" modified="2018-11-07" version="1">MGLLKIGSLYKKNKKKSIIEQSPPVAPPSLPTLSLDEPLKPRQEQEQQTATAGSGSLFDDILAELNSPTAKKEESLLDDFSLALALSQKLDLNHDEPLKKKETPKPTNETVEKKQSNLLTGDSIYSNYLKNLSALDDTSSPDTSMFSSLLNTSHINNNNKSTTPVASSSTPTLKPPVTTMKVLDSDISDSEESKKDDDEDEDDRVTRGIRPIMERRTQDHRLKRKIDSWTNRVDPNANRVESNESMIERMKDRHRNQVKLAALQRQQEMQNMMMMNMVPQPYVLQHPGNLMMDTNNNSGIFPSFPATISSQPQPPLQQQQQQLPQQPLPTEVHPQPAVAEYPQTKVYQQAPHVFNNGSNITNSNTSIYATQAASTQSSLSSAAKEEEPKQQEDDDTHDEGDGAEADGEISEDDESYSVIQRKKSFTSVKGTTPSTEHRRTMRSSRSTPNLKKSKKKSSHSRRSSQDHSASTPSSSSDYPLTPPLPHHQQQQLLQQQQQQQLQLQMQHHSQQLYQHQGHLPQQPIRHMKSEPELIHRRKTQQMMQHQQQLQHEWDRMQAYQREQQLKLMQQQQYMSMYPVMYYNQPMMMQPSKSTSTTARMSHSHSFHTTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J650</accession>
    <name>A0A367J650_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Osmotin, thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002100">
        <property type="protein sequence ID" value="RCH85432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J650"/>
    <dbReference type="STRING" id="86630.A0A367J650"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23400" checksum="F4C24F1283D34A11" modified="2018-11-07" version="1">MTIAAPVNSTSDQPTIIVKNQCNSTLKVGYSKDVDYFGKVVNVAAGSTYTIQPPVGWSGRVWGRESCSGDRCFDSGMGSPASLAEFHFLDSGNTFYDISFVDGYNLPMVVDPASKSKSGDTDGRMCSTPSCKKLPECPAGWETYDNDGNVSGCKSACTKFNTDEYCCTGAYNGQDLCSGNQYTKQVKDVCPDVYSYAYDDATSVFMCGTRTFTVTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6R9</accession>
    <name>A0A367J6R9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coth protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002075">
        <property type="protein sequence ID" value="RCH85529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6R9"/>
    <dbReference type="STRING" id="86630.A0A367J6R9"/>
    <dbReference type="OrthoDB" id="2387105at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016711031" description="Coth protein-domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66214" checksum="9BEBDD85F1DE94CE" modified="2018-11-07" version="1">MKLSLAIISSALLVAVHAANIQFNVIAPNATDVKVSVNGQQVALKASNPSVPYFTGTAETGSATTYKYVVGGTEEGFDRSLKGITNSTYNDFINRPVTYANLPQLPWPIENNPQWTRKGPKPEIFDDNYIPTVFFQGDDAQVTNLVKNVPADRVSGTLTFIGSNYVYTFQNVSFGIHGAGKKHNNAKQSWNWRLSGSDSMGNRNFFKLRHMEEDPTQLRERLYADVLHAMGTYANEATMVRLFINGQGFGTFNMLDDITDFSFINAMFYAGKPPATLGPLFDGASGADFQYHPGNLDGYSSWVANKNNPNGEGYEALDPLCKAWNETNYSDNNAIANFEKMFDVDHFLRFMVMEYLAGHWDGYWMGQTNDGAYRDPTDNNKWYFIDQDFDGTFGVNLAVPEGNNFISVSYKEFPNRYPAAVMINGLLKNPDKQALFEKYLKDTVSVLFNNVTLTNRVLALHEFLLPDLQWDRSIVQQSPGINFGWTFDQVTQNLWQGVSAPNANGGGAAWGLIEWIAARSQAMAKEFNISITTTPVGPPTNSSTTGPATGNNNNSTSSSKPISSNNSSTTNKDASAQSTSSATRPAVSVAFVAISALAAAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J709</accession>
    <name>A0A367J709_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CDA2_3</name>
        <name evidence="6" type="ORF">CU097_007001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002052">
        <property type="protein sequence ID" value="RCH85619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J709"/>
    <dbReference type="STRING" id="86630.A0A367J709"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017058643" evidence="4">
        <location>
            <begin position="25"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="5">
        <location>
            <begin position="128"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="407" mass="45680" checksum="427A19458AA8C342" modified="2018-11-07" version="1">MLLSRKRLLFFFVSFLMMAIIVNAATPPSKHRHFDDDDDDDDDDHKKPKNDDDNDNDSKNNPDSETTTPKKESWLEDIDFDAIEGEVRPVGSGICKDAKCDGTDNDQCFETCGNLATPEDIYGCKHDKTWALTFDDGPSEFTHELLDILDKLDVKATFCVMGSHVKKFPEVIKRAYESGHQIASHTYSHPHLMSLSNEDIVYEVRATEEAIEDVIGVKPKYIRPPYGEADKRVKGLLKQMGYKVLMWNVDPTDYDVYNLKDGAQRIQDTFEKVLKDNNSSLNVHADDGFISLQHDLYRVSIQQVPQIYEALRKHDYSLTTAAECIGDDEPHIRMAAPRPAASASNSFSGKSLPTNLSGFNLPPNNKALFDKQNVDKNKQESSGSIVASVGYISTLLAAMAAWINYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J713</accession>
    <name>A0A367J713_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_005486</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="PJQL01002029">
        <property type="protein sequence ID" value="RCH85723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J713"/>
    <dbReference type="STRING" id="86630.A0A367J713"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="15">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="243"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="16">
        <location>
            <begin position="535"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="695" mass="77153" checksum="E7088A7CD15B28F4" modified="2018-11-07" version="1">MSASIIDPFRYRVAPPFELNRHQEETLAAILDTFIATLPKEQADDLVEKLKKTHTEEEVRRFCQISSTSIDSISSTIRLINNTVLPAKRVELMKLLSILSTRPGTFALTGYFSEFKNLPFADREKIILGWKNSYVPSLRTIYKSFHALACLPAYKGHIQAFTDALHYDTKNDTVYEDLPERLPMMPFDEVKDNMHFDVIIVGSGAGGGVVASQLAQAGKSVLVIEKGKYYHENDFIHTEQDGYENLYELGGFAPSLDGSISIASGSVFGGGTTVNWCASLKLQHFVREEWAKQGLTYFTSPKFTKDVDRVFERIGATTEGVKHNGSNQVLIDGCRALGYPVSDIPQNTSGRPHECNSCYAGCRAGIKNGTMNTWLRDAYQHKARFLEKTKVNKVLIKHGKAIGVECLVNYDKKVRIRANQVVIAGGSLQSPGILIRSGLKNKNIGQNLRLHPCSIVVGFFDRKIRTFEGSIMTAVSGVAENLENDGYGCKLEVPCLHPGSYSTIIPWRGAAEHKEIMMRYEHCAPILILSRDKDSKGSVTYDKDDNSVVNFAVSNRDRRSLLEGILRSLDILVAAGAHEVHTGQFGVDGFRFKEEEEIRIDNPRYVAWKNSVSSYGLPRDGFNMFCAHQMGTNRMGISPKTSVVKPTGETWEVKNLYVADASVFPTATGVNPMVTVETVALHIADCINNNAQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7C9</accession>
    <name>A0A367J7C9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002008">
        <property type="protein sequence ID" value="RCH85816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7C9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="10680" checksum="B4704F321658EACD" modified="2018-11-07" version="1">MINQWSHLSETYTIDNEMSGPTTTLNYEEAILSASDAECGEWVPMSIQSFNPPHTHYVLGNATVIESIVATQPKGKFDLALANQLRTNDISDAVLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7Z1</accession>
    <name>A0A367J7Z1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase, family 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001955">
        <property type="protein sequence ID" value="RCH86036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367J7Z1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1649" mass="178225" checksum="3140B76CA8E1A251" modified="2018-11-07" version="1" fragment="single">EADKAAKTEEVTEVTEEVTKVVDVVKDTVTETIVADKEVSTAVDTIVKESDSVTVEVIAGDKKRDIVVDTVDIQQTIENVDVNVHKSTSDVVEEATEEKTVSDVTLDKETITTGTIAGVVSKAIIEDKEISSAVETLVKESGSVAVEVVAGEKKTTEVISLAPVEEATTEVSKVEIIVRPTEVVSTEKETAEVVKTEDIVTGVVAGAVTEVIVDNKEVSTTVEKTIKESDAVAIEVITGEKKFETAVDTTTTEETLSKVNVVTDEKTADNTITKSELVTAAIVAGAVAEVVTDKKEAFTGVVEAGKTTVEVVAGDKKADTTVPTVTKDEKVTSDAKVEVIVKEADASSTGQVITEKEETVIVDSDEVVTTGVIAGTVAEAVINDKNAKLEGITKKTDTVDVAVTTSTTASVTSSDTTAKKANVSVDSKVDVIVKESDITNADEVVEPETVETISVVEKPICGGYLAGGIIGNIVSDKDATTTIGSAVKESDSVKVDVITEEKRVEDVEVVEDKKITEAYAVGAVAGAVTETVVADKETLSAVETVLKEADSVTVEVVAGDKKAETIVDKTKAEKVVSDIKSREVEDDKEETVTDAIKEIATGIAAGAAAIFGSGKKDTSKDREVVADKKVSVVEEKTEKVERPTVTEEEVISVAIGSAERTTESKSDTIVSTDSQVVEDVETTITGEKDIATKVVSVTSETGETVVADIEVKEDVTKAKVHGEKDVNVVVQDSKTVVDKDTKVKHTQDIAISAGAAIGAVVVGDVEKQDTSKTTVIVTKETLPGTYIAECINVRYYSNCFIVEQVEVINHVEKAADAANSWFSRFIEKITSMIEIGDCVEDVDAVIASEESNLQAILEKSKAQATTSVEEIDVYYGKLNESIKSQISNIKATVKEAYAEGDASQKISLHLAKEEFKKAVVTQVEETKQVVYEKVKPETVVTQKIEAGPDTSIAVVAVSDKPTAVSEVSEVTTDVVYYETAEDAQKKTKELVTTVVQDTQSKLVSWYDVLFGKIRGVIASTEKDTAEKKKDIQRLITDANKEASVIITEAKKSFEFDYTVSDKCDSKVNETVQVVQKQAIESFENIEKIVSTQISAVEEIVVSEEDLESIKEKVSVIETQSKRRATVALETTAESAISVGFEGKSVTWIETSEFPASFKDVKVFAFDLFDTVYDYRLTIYQVWQTIVATKNVSTFAQVDVEKLIVRWYQVFLEQRCKITYATCDREVLLNSLKLVLAEYSLEDAFTAEELNTLCTAWFKLQLFYDSTSSINKVKQVDGTFAVAISSGFKLCTLMKNARNTGINWHAQLTGDVFAACISRDNITDLKSASGIVLSNAAMLCCVTNPSELAVVSSNPEILEVAKLNGSKTVLIDRYDSITSSQEYDIKFDGLDIFAESYETFVETKTAAKNEIPATRSWFQRVVSTVANTAESVGHALIEELFFDQNDAVLQKTIELSNEAGLPSHNVSPTQDRMLAMLVQLKPDKRVLEIGTLVGYSTIYFGRVLLSVKSNDAKLITLEKNLKCAAIAKENTERVGLSSIVDIKIGAAIDFLDKLISKNEAAFDLIFIDADKINNTEYYKRTMQLVKSGTLIVADNVIKAGEVLDKSSQDPRVKGVRAFNDYVSKDNRVCATAIQTVGCKGYDGFAMILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9D5</accession>
    <name>A0A367J9D5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001841">
        <property type="protein sequence ID" value="RCH86562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9D5"/>
    <dbReference type="STRING" id="86630.A0A367J9D5"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35762" checksum="F29E7513BBE879CA" modified="2018-11-07" version="1">MPLADTYRNKEKGSFGVLNFRDLGISTADNAENKKYIKEGLIFRSATLDNMSQEEVDEFIKAHKIKTILDLRTGIEGKGGLPIDKSFPTSALDNLKPTAMLKEDNEPHAMIKTEVGSVGSTLRKKYKIDFAGKNFQRYCVFASCPLSLKLYVILLMIFCQRQKAAYVIGKEVLSKMGVKQMYKEFAVYCQEEIREALMVFADPKNYPIEIHCTQGKDRTGMVAAFVLCIARVPEDIIVNDYAKTQKGLAPVYKEMLEDVRRAGLSDDFAEAPPQFMRELLDFLKQRYGSINNYLDAIGFGEELRERVRKVICLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9V3</accession>
    <name>A0A367J9V3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CU097_006193</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:12276"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.4" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01001816">
        <property type="protein sequence ID" value="RCH86675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9V3"/>
    <dbReference type="STRING" id="86630.A0A367J9V3"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="7 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="19">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="18">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="17">
        <location>
            <begin position="258"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="365"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="394"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH86675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="45017" checksum="81EBF48CE420B5E8" modified="2018-11-07" version="1">MLSRFVKTTVQKSLPKSFIPRHFSTAYNAAVAGLSPQQEELRSAVHDWVNVELAPRATEIDKTNEFPMDMWRKFGDMGLLGVTAPQEYGGLGLGYLEHTMVMEEISRASGSVALSYGAHSNLCVNQIVRNGNEKQKAKYLPKLISGEHVGALAMSEPGSGSDVVSMKLRAEKKGDHYVLNGDKFWITNGPDADVLVVYAKTKPEAGPKGITAFLIEKGFEGFSTGPKFDKLGMRGSNTCQLFFDNCKVPVENVLGEENKGVYVLMSGLDLERLVLSGGPLGLMQAALDTVIPYVHERKQFGQPIGEFQLIQGKLADMYTKLMASRAYVYAVGRACDQGNISNKDCAGVILYTAERATEVALDAIQCLGGNGYTNEYPTGRILRDAKLYEIGAGTSEIRRMLIGREFNKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBM5</accession>
    <name>A0A367JBM5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001674">
        <property type="protein sequence ID" value="RCH87362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBM5"/>
    <dbReference type="OrthoDB" id="2267907at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016860235" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="165" mass="18165" checksum="BB3DD048821D4D5B" modified="2018-11-07" version="1">MHTLLLLQLILLALSVHVIYCEQYEPCLATAKNQRLNHGYTFALAKVKDTVSPLGPQEACYFSCGARIVTHSTNKGDMNKLTAMDSAAPYLSIIDFLKIGQSYFVNHLGLKEEEGGTGIGCMHVESVKSAKYYPRNHPLCQKADTAICGFWGTQPVPEAKDKMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBT1</accession>
    <name>A0A367JBT1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001669">
        <property type="protein sequence ID" value="RCH87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBT1"/>
    <dbReference type="STRING" id="86630.A0A367JBT1"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47821">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47821:SF2">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26274" checksum="0DC6995F3D7E070A" modified="2018-11-07" version="1">MTRPLYNHLPEQLKNRYIIQRHGFSLANNEKLICSNPDIAIPPTGGPLNTGYGLHDKGKEQVKESALRLSKHLFPSQQKLDDNPVVIFCSPFKRTVETAEIIQGVLNDTVLQGKLGAPIKSLELRERWYGQFDMTNDDNYNICWADDAAAPDHGEHSQYDIESPSSVCDRATRFIVDEIESKMEGKTVILVAHGDICQIMLTAFKGTDAWRHREMEHVDTAHWRDTLDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC62</accession>
    <name>A0A367JC62_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001655">
        <property type="protein sequence ID" value="RCH87449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC62"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8399" checksum="8C17D65AB644AC7D" modified="2018-11-07" version="1">MHPAIRHFFKRSFSHPEVVPLMIIVGSALTAATYSGYRQLHSPGLRTNFHQTSLPNWNPVNDRDRVRFHHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCB6</accession>
    <name>A0A367JCB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cofactor of BRCA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">COBRA1</name>
        <name evidence="1" type="ORF">CU097_002258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001628">
        <property type="protein sequence ID" value="RCH87578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCB6"/>
    <dbReference type="STRING" id="86630.A0A367JCB6"/>
    <dbReference type="OrthoDB" id="5548359at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06209">
        <property type="entry name" value="COBRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="604" mass="70862" checksum="6D59841337FEADF2" modified="2018-11-07" version="1">MSINKKILIGPAEEEIRTKLSQSREPLEVIRAFQKEYGLDLPGIEHMYPLLDLCGYSRYEIHKACLEALNKETVRYIESPSFQLEKYVFLHFNTQILTLQKHMYSFYDLFKKTFPYIHIPLMQPIPMALLKKFERHVEEDVIAKLKSDMNVFANCPLNIKQRVWKQDEAFFHQSMLPFLNNYHHDEALQKLTINLKPDSYQEVIEQRRTHPIVQRFMEVIDGDPDIYRMFIKMIRIVFETTPYPTLCSLRIDILMNYHDLGVEKIYAMDRCHQLIWSLDTCVRNQNLDESIIEKIKECFDDVRNGTPLYADFAMVLMDPMISNFLTSCIVKWLRSSVDDNTPQGVNLEELIDYTAKLLNLAEHAPQAIANNTRIPRLDQELKTSLWTVICSIFLSEDADYKVPIKESDYTILHAMLQRSDIARKVFVHYLIDRVQERDIGTLNRCLALVMNTWPSENYDERGIIYRQTYVGFVRTMIDILSKRNLNELVADVRWRQAVVEGFLIKAVAWDVKIHDQMIYLLTEYFNDPKLLIKLGPQVAILSDWADMIVMNGLVDDKYRDYLRDAYIYLVTKSQTVLNGDFKIMPSAVIRFCETGNTFSSQTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDM8</accession>
    <name>A0A367JDM8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_010420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001541">
        <property type="protein sequence ID" value="RCH88043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDM8"/>
    <dbReference type="STRING" id="86630.A0A367JDM8"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000217">
        <property type="entry name" value="Methyltransferase protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="25343" checksum="FF2A126C96A891F8" modified="2018-11-07" version="1">MVASTSLNVLPDDPTAYKTQEYWEQRYQQEDVNTTFDWFKTYADLKPFINEAIPNKDSKILMLGCGNSTLGEDMYADGYKYITNIDYSKTVIENMKTRCADKPEMEWLEMDIRDLKFENESFDAVIDKGTMDALMCDRGDVWDPSEELIKDVKGEVDEVERVLKVGGIFLYITFGQPHFRKRHLQRDCWTIDIKTMGDAFHYFFYTMSKNKPCTNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE04</accession>
    <name>A0A367JE04_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4436 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001528">
        <property type="protein sequence ID" value="RCH88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE04"/>
    <dbReference type="STRING" id="86630.A0A367JE04"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35818" checksum="010E2CE2AD5A78DD" modified="2018-11-07" version="1">MIQTIAEHHVLRRSFICFLILATLLAMIVPTWQVYLEEGRSSTLISFNEPNIRGESLYIAASVLNVDFSEKRYTINFSIQPNGTLANEYGQLNQQVTLRFSSLRSYHYDIGETIHPIQATFNYENGNQIDYPLDIYSGNLEIFAFYKNDTTKSIPITFHLDASITSFHFMPSIKHNPVVEDDGNDTPFVNDKISLQISTGRSTTTLAFSIFICILMWLLSLVMGLFGYQVVFRKRKADAHACMIGITTLFALPAVRSAQPGIPEVGTVSDILGFYWNMAIIACSSIAVTMCWVIRWDDSMDRDNKRNMSISTCVDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEA4</accession>
    <name>A0A367JEA4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane and coiled-coil domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001505">
        <property type="protein sequence ID" value="RCH88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEA4"/>
    <dbReference type="STRING" id="86630.A0A367JEA4"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF23">
        <property type="entry name" value="DUF726-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55850" checksum="1E68933B3F478A55" modified="2018-11-07" version="1">MPNDKPLIKLSVKDWTREQRMAIARVTGQALTNCAMGEPWSTDYWNKLLSYLDLTQKQLCVLTVDQAIDTLSSHKDIRIDVMLDLVALSIYGHQKAEMYYDARARNLLLELERLLQLSYGDLNAVERSVSQQMYYALQEQQSSSHTDNMGASAKKAVQEGNKKQQALRWVATGAGILGGGAMIALTGGLAAPLLAPLLVGVTGAGFFATAGGVALITSLFGLTGGGLAGWKMHRRMKGIDEFEFRQILRDPDLPPIPSLHCTICISGFLLESANETKTPWEHAFEGKHGSGSDIYCLEYEKKELLDLGYSFKRFIKDSAIKYVGMEVAKSTVLHAFFAAVALPATILKMADVIDNPWQIAVDRSRKAGAVLADVLQQRIHGNRPCSLIAYSCGCLVIWHCLLELYQRGCIGIVNHVVLMGAPLSTEDEQEWLHVQSVVSGRFVNCYTSNDWVLAYVYRLHSLATSVAGLEAVKIGRIENLEIPELDGHTKYPYIVKDVLDQIKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEI2</accession>
    <name>A0A367JEI2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001488">
        <property type="protein sequence ID" value="RCH88317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEI2"/>
    <dbReference type="OrthoDB" id="10401146at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15767" checksum="B9D722B5455A43A6" modified="2018-11-07" version="1" fragment="single">ASELWNQANGLLEDDTSASTIITRLQLFDVCTKLYISVILPWHQYVKENKKRMHDQLFVDQKLQTQKKEVNTEQQQHTKCIKMVATPLQAILKDDNESVLNTLRKGQRIASDALLDISIIIELIVEDYLQSGENKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFZ0</accession>
    <name>A0A367JFZ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001395">
        <property type="protein sequence ID" value="RCH88840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFZ0"/>
    <dbReference type="STRING" id="86630.A0A367JFZ0"/>
    <dbReference type="OrthoDB" id="2280816at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="527" mass="60469" checksum="F239B729C2B6F022" modified="2018-11-07" version="1">MISHSNEQADKEEEQTTKEESYYIPKEEEPISEEYDLMLDSSSVVEDDPFYLANKTFYTTCHKISRQNNPSFRKKPPYTFLENWLIHSVFSKSQQILLRFPVIHPKVMMTEGDFIYTPHQMVNDTNFNTNNATNHNIQQPNGYDYYSNEYANHNDEEDDDDDYDYYDDDTFIIGDEGVIVMSAPAPDTSQFVEDEESIHTSSLIMDENTWMGHSKYNGNGLTLHVVNPDLDEDDEEEGDKQRRYTSFHTQLQVVKEEEEEEDEEDYRNTQSSNHQAEYKSTGISMSPEILNWYRSADLKSMKSAIYEEQQQQPTNLENKERDNKMNDSNGILSHNNHNSNSSSSSSSSNSSSSSSDGDDSSSCDDGRSNDDVSQEDMENTSYHAHEPNSAHNNSDDSEKILSRHSSESYQSLADMMEEETENHQIYSQQMSNIVTTGTTTRSVSYGTLLPLNHSYEQKNIPSIMSVSISFVNAAWTAMDIAQTYHEEENEKSFTGFVSCVFKIWKVLLVGAESMLDWRNRVKLQAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHI8</accession>
    <name>A0A367JHI8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001306">
        <property type="protein sequence ID" value="RCH89339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHI8"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="67" mass="7803" checksum="5120821BC5C449EE" modified="2018-11-07" version="1">MNQQNPNIINVTQPNQQQQQQNQQQQPQPQMLQPQQGLNLSLPNDTSNANWREELSVHDRARFVAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHU6</accession>
    <name>A0A367JHU6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_008955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001276">
        <property type="protein sequence ID" value="RCH89510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHU6"/>
    <dbReference type="STRING" id="86630.A0A367JHU6"/>
    <dbReference type="OrthoDB" id="2264563at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="474"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="793" mass="89001" checksum="B9EDDE3072AB6991" modified="2018-11-07" version="1">MTILEPPPRPNKSKLRTLRPDGLSLSPFVTPTTSPTEVTEEDYFSLVTSSSFDERTALHPTATPSHSLREQPKYRSRFTEHFDDHSRDIIEEEFAGLFSLIQPSSPRPSKPEQVKQSKSLAVISENSAKSDTVPKKALVKSSSTNTVTVSSTELANTSPGYARKNSQPAPSLSTPLQSSKGIPSPRKFGSSGSILNASSIPAAGSLHSSMSEQSDSLASNIATKLNRADVIIERLESWNDFLKSITGWLEEVAKINMQSGRGYLQRAGSYLNMNTEDSEYIRSLQNGLQTLVNKLSSEQQDLSSTIHRDHLPGIYKLRKECKEKIQRLKADTSLSMDELYRRAEVTRSKMNYLNRCCKQAERMKGQIEMDPWLANLHVLRQLKREVDEENRLRLLMIPIQNETKEFEQRLFQLVKPAIDYCCKALAKESIMMTPPEQEWSQFCKMHQKELVDEQRPIKNYLKINYPNKLHPFVMTLIKGPMKRRVGVRKQFIERYYVLSQGGYLHQFTMDNKVSPEKTIYIPSVTIVPSIDLSSALYQHYSEDSYTFEICRPGTNVLQKDKVSVFRTTTKQELIDWCTCLVQVASGNLLTETSSNISHPSSPTYSGCSVKSNESILDPSTAQGNRIRKSSFPSRTPLHSPSPLHSSGLKIANNDSFIIEPSSAFSTDSQIQDSAIHYEEEEEEEDRISIASNSTAKVPLESGSRENNDEADRLDSNENIHGQEENRQREPSVISTIFDDAQSSVYFSSTSAPPSPALSAQSSIISFPGLGPLEVTNEQVEVYKPTLSLNLESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIN8</accession>
    <name>A0A367JIN8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001220">
        <property type="protein sequence ID" value="RCH89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIN8"/>
    <dbReference type="OrthoDB" id="2124108at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="298" mass="35329" checksum="DFFA42135D4F6815" modified="2018-11-07" version="1">MTSEDDTFNFNFDDDIFGETKEKQQVELSTIDYQAKVETDGWFHSDKSIEELMLETHGPNQLKNSIEHDYLYKKYDIALNKCLEYIRVARTNDQCKVSGTKELVEMAMHCAAKLNKLDIINELLDEKQSTVDTGLLLTRGKFLPLVGRYKEAMHTYIEYHKERKLDYKIWNAMANVFMLSAENDSEKRQDMRYHLANLSMIRAIHIYTNSRWRNKIDFVKDRFEKELESLEARLKITKERRGDADKFVEWMSTDDKSIEDAGLSSFDWQDIIWIYKDWILRQDIEVEEDNTIKAVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ53</accession>
    <name>A0A367JJ53_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HOM3_1</name>
        <name evidence="9" type="ORF">CU097_005325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001195">
        <property type="protein sequence ID" value="RCH89984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ53"/>
    <dbReference type="STRING" id="86630.A0A367JJ53"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="436"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="509" mass="56349" checksum="57A490ABF9455E4D" modified="2018-11-07" version="1">MVRSFTYRNNSDSPWVVQKFGGTSVGKFLDNIANDVIKEYVKQHRVVVVCSARSGESKATGTTNRLIRAANDAIKPGSKEYLNIVQDILDDHLAVATEMIRDDAIRNHLEQDIRNDCEKLKSFLEAAEIIDEISPRSKDVIIGVGEKLSCRIVAAVLQDRDVDAQFVSLENIIDRDFERLDQSFYDYLAQRMADAVKQCENRVPVVTGFFGIVPGSLLTTVGRGYTDLCAALTAVGLGAEELQIWKEVDGIFTADPRKVKSARLLPIITPEEASELTYYGSEVIHPFTMEQVIRARIPIRIKNVENPRGEGTIIFPTDNANSRDGTHTPQSPQVLAENGYSIDLSRKYPTAVTIKDHVIVLNIHSNRKSVSHGFFAKIFSTLDRYGVIVDLISTSEVHVSMALGEENLDKDLDRVIKDLKEFGRVDVIKDLAILSLVGKQMKNLVGIAGMMFSTLASAGVNIEMISQGSSEINISCVIDERSAVTAMNVIHDQLLSKHSKLVLSSLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJQ6</accession>
    <name>A0A367JJQ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Rad2 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">EXO1_1</name>
        <name evidence="17" type="ORF">CU097_005797</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001166">
        <property type="protein sequence ID" value="RCH90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJQ6"/>
    <dbReference type="STRING" id="86630.A0A367JJQ6"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="496" mass="55968" checksum="020B884AA00B6822" modified="2018-11-07" version="1">MGISGLLPLLGPITKPIHIQEYAGKIVAIDGHCWLHKGSFSCALELALNKPTTKYISYFMNLINMLRFYKVIPLVVFDGQPLPMKQETNNKRAQKRKEAYKTGLKLISDNKMKEALPYFQQSTSITQDMIQQVIKKLDEVGVQHIVAPYEADAQLAYLMKKNYVQAVVTEDSDLLAFGCSTVIFKLNRYGDCERIFFNDIPQVINIKPFTTTTLRHICMLSGCDYIPSLKGIGLKTAEALLRTHTTIEKVMRALRYKSSVEQYQQDFERAEYAFLYQYVYDTNMRDCVRLNELPENANQDHLPLLGTHPEQTKPKDITNNEFASLFYDKESNKENIPPWLRYDDKRAANGNSSPSGSGTSSITALSTVKSDKLATKSSMAKFSLSSKFKALTKDKPLKKVMAVKKDVVKDIVELTTDGKTSLKRAFSFTSQGDSQENQDDYPSSLPSLSDSVSTLSSQEENVEPFIRLDKHKSIDTTINLHVNKKRVLGSSTNVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK46</accession>
    <name>A0A367JK46_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PKA1_4</name>
        <name evidence="14" type="ORF">CU097_005225</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001142">
        <property type="protein sequence ID" value="RCH90303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK46"/>
    <dbReference type="STRING" id="86630.A0A367JK46"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="95"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="350"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="404" mass="47056" checksum="78FCF6737F400E63" modified="2018-11-07" version="1">MSFLHKIMNKATRQNSQSSSSSSTMTQDSKHQRRSFFGFGGTTQEDDKKPKMEQVPVSDENTVIEREKLQQNYLNYDRQILQQRKNKPQLKLDDFKLSRTLGTGSFGRVHLAQSKHNDRYYAIKVLKKSEVVRLKQVEHTNNEKHILETTANPFMVNLWGTFQDDIYLYMVMDYVPGGELFSILRKNKRFPDHVARFYAAEVVLVIEYLHSKKIIYRDLKPENVLIDVNGHIKITDFGFAKYVSDITWTLCGTPDYLAPEVIQSKGYGPAVDWWSLGILIFEMLAGYPPFYDDDHLKLYEKIIQGRIKWPAYFDPHARDLLKRLLTGDLSRRFGNLKAGAQDIKDHRWFSEIDFVKLANKQVKPPYVPNIKGEGDCSHFDKYPETNEIYGANGPDPYRERFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKM0</accession>
    <name>A0A367JKM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001113">
        <property type="protein sequence ID" value="RCH90492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKM0"/>
    <dbReference type="STRING" id="86630.A0A367JKM0"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="121"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="35525" checksum="30E44BF7BF6D2E22" modified="2018-11-07" version="1" fragment="single">LPETGLVEKFGPVTHEPKLTPTNEYTPVQQASLTSEQKDKLEKLRNYIESIMLPKDHEYYPNEKGFITEATLKRYMRARKWDYENAKTMLENTIRWRRDYRPDQLDPEYIKPEAETGKMYFNGFDKCGRPVWIMRPRLQNSKDADRQIKHIVFSLERGIRLMPELVENLAIIVDFKDSSASHNPSVATCKKFLDILGNHYPERLGIAFVVKSPWFFFATFKVISPFMDPVTKNKIKFVYDSEKEKDTKSTSNEWVHIQDYIDPDQLECDFGGKFNYLFELEPYWSALLERTGNPYKVIEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL84</accession>
    <name>A0A367JL84_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001083">
        <property type="protein sequence ID" value="RCH90693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL84"/>
    <dbReference type="STRING" id="86630.A0A367JL84"/>
    <dbReference type="OrthoDB" id="10558658at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834880" evidence="2">
        <location>
            <begin position="21"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="550" mass="62764" checksum="626D62EDCCDC8832" modified="2018-11-07" version="1">MKIFVLSSIAVFTFASLVAGAPLSEGQTKFQFKGIERNFAKRDAILTENLLNNDPSGGFKQDSLALDPNADVKKLKEMEAELARQVAVDEAVKIRWQERLELEKTKKGDDDKGKGQTEKGQDNINKDPVKESPQGQHQEEENGDEEVADKDVDSNNEKAPDDDKEVADNDKEVVDNAEETADNDKEVADNAEEAVDDSDEKIADNDEKIANDSDEEVANDDIGDGIENDTYNENEYSDDNGDYDGADNDDYYDGYNDNDYDENYGINYGNNGGNEDGDSYYDDGYDSNSNNSNYYYDDGDNDGYNDNINDSNNYYDDGHYDNNNDSNNYYDDSDNDGYNDNSIDNSNYYDGSYDDNNDSSNYYDDGYNDNNGDSGNYYDGGYDDENKDSNNYYDDGENGGYNDNNNDGAYDDNINNSDNYYNGSYDDSNSYYDDGHDDNNNDSKNYYNDGYNDNSNDSSNYYDDSDNDGNITYKDDDYNDDNSNYGDSYDDDYDYGYSYDDRYDYGYDDGYNDGSNDSNFDYDYDYDYDEYKRGYDDDDNGQYKYYDSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLN1</accession>
    <name>A0A367JLN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_006702</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001060">
        <property type="protein sequence ID" value="RCH90837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLN1"/>
    <dbReference type="STRING" id="86630.A0A367JLN1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004483">
        <property type="entry name" value="SMUBP-2/Hcs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00376">
        <property type="entry name" value="IGHMBP2 family helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="188"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="206"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="666" mass="74624" checksum="D378BBE95C502E69" modified="2018-11-07" version="1">MEKFIAHQRELIETERKVDVEETIKLLSSYAPIQLQRRGIALVGLKITGMRTGLGGKSLIDLELANPNILPPILPAHKITTGDIVGLDVYKKDKPSKNVDKWSGVVARVTESRITVALSQEIEDELPAELQERCQIVKLANSITYERMLKGLEALQQRCDEGGSRLINVLLGQSDISTPQKMSDIQFFDETLNDSQKEAVRFALGSNEIALVHGPPGTGKTYTLVEIIRQLVVNQGQRVLVCGPSNISVDNLVERLAQHRLQVVRVGHPARVLPTVIDHTLDVITRTCDSGRIVADIRKEMDDTLAKIGKSKNRTERRAMYSLMKDLRKDYRVRERKVIDEVLTNAQVTISTLNGAASRNMMNREFDVVVIDEATQALEAECWIALLKAKKAILAGDHLQLPPTVKSPIKIQTSLKSKGLSTDTDLTTTLFDRLLAMYGNRIKRMLTVQYRMHKKIMEFSSKELYENKLVADESVAEHVLADLPEVEHTENTESPIVMIDTSDTGLSHEVTDDAQEEQSKANELEVQLAVQHVKALLEEGLQEDQIGIITPYAFQVSKLRREIREHWPGIEIGTVDGFQGREKEAIILSLVRSNEMGEVGFLAEKRRLNVAMTRAKRHLCVICDSDTLLGNKGGGSALNRNDAGFLKRWIEWLSEEADLRFSELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLY2</accession>
    <name>A0A367JLY2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001046">
        <property type="protein sequence ID" value="RCH90928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLY2"/>
    <dbReference type="OrthoDB" id="2242533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="13582" checksum="123AF7D07CE56C15" modified="2018-11-07" version="1" fragment="single">MRWRRALLLQRKLTNTEVIIGHKTIQQLLIAFRWHHQLLNPFRIKLPPEYGIVFKLWLPIFDCIFVGDLLLATRITETVNECTAAQKQSIYAHIKHPVTDYEIDIRFLFVDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN68</accession>
    <name>A0A367JN68_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PQ loop repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PQLC2_3</name>
        <name evidence="8" type="ORF">CU097_011640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000984">
        <property type="protein sequence ID" value="RCH91335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN68"/>
    <dbReference type="STRING" id="86630.A0A367JN68"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="276" mass="31560" checksum="574960FC3A779C7A" modified="2018-11-07" version="1">MDCIPKDQAIQWIHSLFGSCVYGYAELSSQLFGYTSLFCWLCAQLPQMVENYQLQSADGLSLYLLYFWLAGDVANTVSCILNRQLPFQIYLAFYFCMTDLVLLFQYFYYRKSSFIESKAQELFATESREIVETAPILSTSPTYGSVKNSKRQLLALFLVFGFKSQSNLVVDSVVLGRLLAWACTIFYLSSRIPQIIKNHKRHSVEGLSLALFSFAVVANITYALSIILHPGHTRETFINALPFIISAAGTLLFDMIIYIQFLWYNRQKDKFSSLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNE4</accession>
    <name>A0A367JNE4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000969">
        <property type="protein sequence ID" value="RCH91446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNE4"/>
    <dbReference type="STRING" id="86630.A0A367JNE4"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="341"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="82973" checksum="392350525E991894" modified="2018-11-07" version="1">MSIKTRHSSIDALRERYQKARQWAVDNGTLSTSPTVTTVYEEEEHEKSEEEEREEEKEEEEEEDDNNSIYSSSSSIPDEDINFDLVYALHTFVATVDGQASVIKGDAMTLLDDTNSYWWLVRALKTSEVGYIPAENIETPFERLARLNKHRNVEVTSIARLPDHVSNNSNKQPKKKRVKLSKELACQLQIILTDEDNDSSYEQVFEHWEEVMSINSALSTDNTDVDDISQSSISSSNSDNDDDDDDNKQTIKTASTLILNPELNRSIHLIQEEEDSRATRENNKNNKPLPLLQFDDSKKDVQGQQHQQQKSVTGLKRLFSIGNSNSKKDKIEEFVENRQYHVLRIFAGNINVGAMFATVAVTPDMNADQLLKLALQKFHIPLLTDKSNTIEYYLTVKSMDNDELTLLPQDKPLAIFESLSDHLTTPMPSLTSIKKLSIEQPTIKVTRVGVSKARQRAKAHFGEDSVIRFSLHKRIKRTIDGQVYVKISYYVDNDNIKRGSVLRKSSLLRKDVHPKKFLKKERIDKLVATSSLTRISDLIITALEKFHLKGQDYNMYYMTILINGRSEKTLPMDRSLVDILNDSELIPKGTTEKSFILHKKEPMQSAGVTDLSYDNNRRSMVRKLLKQQDSNHKYNLSSTETVIKKLDEAIQSLEHDKRQISAKVTPARSNSLSTYYDKKHSNDFKRSLPTRSSSLKLSGDAFDSLHDSDLSNMDDLELELQRIATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNM7</accession>
    <name>A0A367JNM7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000966">
        <property type="protein sequence ID" value="RCH91469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNM7"/>
    <dbReference type="STRING" id="86630.A0A367JNM7"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="2">
        <location>
            <begin position="207"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="47137" checksum="E73D0A67506F5CF8" modified="2018-11-07" version="1">MSNLSQLLTIKLWEEIEFDQYSSKSKRNWEIEEQKLQELQALPPLSRTDPSNMNVKSLRDLDLQQQFWDYIMNRIWNLDKPECKESWEPIVFDFRKLREGIIASYWSNGDIGFAIQAFEWSVNAALKAQNFEEMFKCLRGLVDELYPLKDSAKKTYFIVLDTLYFCCYLKDMKVVINRLELMKDIDTKETKFVKKLIHCIFVSENPLKYFELYQNAPYLTYKVIMEHYHNTIRTRAIRTLRKAYLSVSLEWAKHWLGLEQEVDVVPCINKLVPCVDRVDVDRQIVYFIRSVKKKPVAVNDAQGTPTASPKMAATSAVQAAEPRTMPNSPIVSLTESSTRESAESSYARSTVNTPRQQKVPSTPSLTTRNNKVVNEPAMMTDNEKIALYEKKMRTIVDTLSSDDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQG6</accession>
    <name>A0A367JQG6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPS1_2</name>
        <name evidence="6" type="synonym">RPS1</name>
        <name evidence="8" type="ORF">CU097_011839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000901">
        <property type="protein sequence ID" value="RCH91931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQG6"/>
    <dbReference type="STRING" id="86630.A0A367JQG6"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="29649" checksum="B2A1CD5C644F61DC" modified="2018-11-07" version="1">MAVGKNKRLSKGKKGLKKKVVDPFTRKDWYDIKAPSMFEVRQVGKTLVNRTQGLRNANDSLNGRVVEVSLGDLSKDEGRAFRKIKLKVDEIQGKNCLTNFYGMDMTTDKLRSMVKKWQSLIEAFVDIKTTDGYLVRLFAISFTARRRNQIKKTTYAQASQIRQIRKKMFEIMTEEASACDLKELVAKITSSASHASQDAIAVRIEKACQGIYPLQNTYIRKVKILKAPKFDVSALLALHGGAAAAADDTGAKAAKEFVEPPILASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQL9</accession>
    <name>A0A367JQL9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CKA1</name>
        <name evidence="12" type="ORF">CU097_012932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01000859">
        <property type="protein sequence ID" value="RCH92228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQL9"/>
    <dbReference type="STRING" id="86630.A0A367JQL9"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="44"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH92228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="337" mass="39672" checksum="75AB19AD0C96809F" modified="2018-11-07" version="1">MSASTNATKYKSIARCYADVNAKMPASYWDYDNLQVEWGNQEKYEIIRKVGRGKYSEVFQGINITNNEKCVIKALKPVKKKKIKREIKILQNLAGGTNIVGLLDIVRDPISKTPAIIFEYVNNTDFKILYPRFTVYDIQYYMYELLKALDYCHSKGIMHRDVKPHNVMIDHEKKELRLIDWGLAEFYHAGTAYNVRVASRYFKGPELLVDFQEYDYSLDMWSYGCMFASMIFRKEPFFHGHDNYDQLVKIARVLGTDDLFRYTAKYSIKLDPEYDNILGRHLRKPWTKFITADNQEFASEDALDFLDKLLRYDHQERLTAKEAMGHHYFDAVRQNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQZ3</accession>
    <name>A0A367JQZ3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000875">
        <property type="protein sequence ID" value="RCH92111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQZ3"/>
    <dbReference type="STRING" id="86630.A0A367JQZ3"/>
    <dbReference type="OrthoDB" id="2247655at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44885" checksum="FF054736BF202317" modified="2018-11-07" version="1" fragment="single">MGKYNLEKAHTLVNGHVTPYTTWDNSDLKTKRQKGDFFSLFNEIDGIEARSNADQHIKDAISQIERDQAKRLEELRQQQDLDSEESLVDEAKQLSTKSVIISFDTLKLEFDEDNKGNALFKIALMDEDIKLHQTPTWPVPDPVPIMSLERMLTLRKYEKMQHGIEDIPLSASNPKVAEIYKRLGVFLSRYKIGRLPRSFKIMPMLKNWEEVIYLTQPDNWTPQAMYEASKLFMSHNTAQMQNYVLFPYTRRRIANNNNYHLEYPVFLALQTALLNARIFTLGYLKPLCESGECTAMEASVIGCIMALHTKLKPVPILWSLMSLPFSIPTTLFILVALERKRKRIPRTFYKPLTFYFIRAAESANQLPYIWYQALYVFAKYCADELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRA6</accession>
    <name>A0A367JRA6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000821">
        <property type="protein sequence ID" value="RCH92484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRA6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="110" mass="12848" checksum="9B7975E30DF455BA" modified="2018-11-07" version="1">MNPERRPSVLYVRVDWKTLKQYAIQDLTRERLGLLYSIMDYNGKNDAGHYEISNHNSYWVIRCTNSGCLEQSKPRLWNRDLAAKNPPPRLSPDRSQVLVTTAWSFHAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRE0</accession>
    <name>A0A367JRE0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000816">
        <property type="protein sequence ID" value="RCH92522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRE0"/>
    <dbReference type="STRING" id="86630.A0A367JRE0"/>
    <dbReference type="OrthoDB" id="2283182at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="19152" checksum="34E63D950C04A2A4" modified="2018-11-07" version="1">MKRAVDYYLQANSKYGVEPILSIFCVDALYQEIKDDVAGNRLPEAYSYFCKPWAAECFIISQDSLKQVLTTPLDSLVALGLFFTNRCVSILDIPYTGDQTIQYLYALALHYHQIDAQDIVSLTSKLIDSQIIEYDRLVTLANTLNQPLLVQAVNEAKSRIYETKKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRL3</accession>
    <name>A0A367JRL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SDH2_1</name>
        <name evidence="22" type="ORF">CU097_006237</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="PJQL01000819">
        <property type="protein sequence ID" value="RCH92499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRL3"/>
    <dbReference type="STRING" id="86630.A0A367JRL3"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCH92499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="263" mass="30252" checksum="A0522A41179F0332" modified="2018-11-07" version="1">MRSLKTASNPAAIANPSPPPYEPQKKTPKYKSFEVYRWNPDRPTEKPILKTFKVDLNACGPMVLDALIKIKNEQDSTLTFRRSCREGICGSCAMNIGGINTLACIARIDPDISKPLKIYPLPHMNIIKDLVPDLTHFYKQYKSIEPYLKQRTSPPPDRENLQSIEDRDKLNGLYECILCACCSTSCPSYWWNQEEYLGPAVLLHSYRWMVDSRDQYGKERRERLQDKMSLYRCHTILNCSKTCPKGLQPGKAIQRIKMLMATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUV8</accession>
    <name>A0A367JUV8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000663">
        <property type="protein sequence ID" value="RCH93723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUV8"/>
    <dbReference type="STRING" id="86630.A0A367JUV8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="557" mass="64274" checksum="0EAFD08A172ABDCD" modified="2018-11-07" version="1">MSLQRKKKPVEFHFVDMNDPSRYKKLKVSRACDFCRRRKSKCDIGIPGSGTCSKCRKHQIVCVFSPVSTVKGTSPQTEDVVLLTPTISIPMNYQEFQSKYSSLSVKNGQPGYELLPQQHLIITNNTTVAMTAEPTKELEDTLFHIYFAFVHPAYPLLFKQCILDIHSKDKYLLSHSLRYAIMSLSSIYHNNDYSMAFYQLAKDHINITSPELLSIRLDTVQTLLLLYKYTEISFITPDVRYLELANVILKQLNSSLMFQQQEMINRARWILFASVGLSNLSDPSFNKLYSEIDLPTHLPQPFKEEHNEDAFWNKFSQVLNLSVLYSHTIQSIITGASDIDIHQFMSIRQHWYDSLNPSVQSALVCENGQVIDILPLYTAIIYDMLYLLLLLHQQHQVKRGITIETAYRLQRMIYKWVTHSQFISAIQSKRMAVFGLLLCLQVYIIANIFDCIENIRLVMKHIQHIDPKIDQQLNELTRQLTIGRIRTPNSPLEEDYFSLIPMHSTCSSPSLSTPLFVNQNTSPLAKDELDILLQEQLQQLQIKPVCYFNSNNSVNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV80</accession>
    <name>A0A367JV80_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC7A6OS</name>
        <name evidence="12" type="ORF">CU097_012809</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000650">
        <property type="protein sequence ID" value="RCH93836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV80"/>
    <dbReference type="STRING" id="86630.A0A367JV80"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH93836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="293" mass="34223" checksum="C4148B87647CF2E4" modified="2018-11-07" version="1">MASDPITILRIKRKRTEEPLEALLLQQQNEEKRLKRSNEDTGVLKVSATALPTIFRLAETVEEASFSNLDEARKLKDRISRRIQPGLSRPQTPTPIEERKEQLMQKQSDVSKKARYRVISQNRAKAMENMPPVVQSSSERAAEDLFQMYEAVRDDETTAKQPKLILDEDTEDVDDIMCNFIPMIKEYLTLNDREQKQEDEDDYVYDVYYRDDQEPNALNVNNVGSLVWFDDTTEYMDDNDTESEMGDVGDEDSNAEDYYQNDYPDEEDDHDDHDEFEEQYGYDLSSDDEDYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVC0</accession>
    <name>A0A367JVC0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000644">
        <property type="protein sequence ID" value="RCH93880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVC0"/>
    <dbReference type="OrthoDB" id="2244418at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="17576" checksum="E08FE4DAC849DEF7" modified="2018-11-07" version="1" fragment="single">TPPLLMPNDWCLQEDNTSSNMFDDEEEEDNNRETTHNATFTIQNREDSSQHIQNQQESQTQAISSANLFHRANTQQDHDSELDEESWETIVHGLQGEFASYLEEYSQIKRDLDNKKKKLYQEIMERKEYLEQRGAVLYQKWDALKDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWD8</accession>
    <name>A0A367JWD8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000591">
        <property type="protein sequence ID" value="RCH94312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWD8"/>
    <dbReference type="STRING" id="86630.A0A367JWD8"/>
    <dbReference type="OrthoDB" id="2248528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="401" mass="45806" checksum="7B3EFD170606BD2F" modified="2018-11-07" version="1">MECTSYRPLMEYYPETDTEAMELAYEYGEITTLTDFDVPIHDIQMEENMEKNLEEITTELSVVTISEDKKKKNKKKVSVPVAAKRCMIPCSTAYRFFNEFNAGDGTVLSGGSLKKKANRGTAKKIFPEHTRFLVPYFDEHPSSNLEMARGALIGHFEGFTISFPALWKHLTEQCFFSLKQASKYNAERDSERTLRLRQELENATILAVESLFPTLKDLDVRSLVESECSNLIPDNGTDVNHRPDYEVTVFEQCQPSYRTCYRELKGEKFSDTSSIMGFYRLGIFAKLEIVASNLTGVLCFQALGSLITFYTMVHPCSSMFTFVELVTINMPRTKNNIMSLMGFLDELHKIAVYHRTLVKSLAPNAEHPTLSFEFMQGAKKKHCQLRESLLWDQSHPNSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWJ6</accession>
    <name>A0A367JWJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000587">
        <property type="protein sequence ID" value="RCH94354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWJ6"/>
    <dbReference type="STRING" id="86630.A0A367JWJ6"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36574" checksum="1B21EEB4EB34308A" modified="2018-11-07" version="1">MSKYRDEPIKRSNNTIIQWFGLDQFEPERAVSSNFVSSKTLFIIRLPLVLYSFVVLWIDIIWSIKTDQFRHFFAYFTDLTFIGLNAYLVTTQYHHAKYLWFTSSSSQRPNSFLDQAPVLNYLYVYLYHTIIVFNIQTPVVFWALLAQERLFNAHLSPIDFWISISLHAVTLFILVVEVIFNRMKVQRSMIFLVYGTVVLYMFLTFIIFAVEQWWVYSFLDWSVGPSAIIWYVIISLFIVICFFFQMGLHKARDTVANYIHGSTTLFTEKDRPDNAVVLQQTNFEPLASTIGGGSRITFGESNVEPSKASSIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX99</accession>
    <name>A0A367JX99_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_001422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000559">
        <property type="protein sequence ID" value="RCH94604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX99"/>
    <dbReference type="STRING" id="86630.A0A367JX99"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17954" checksum="1B2D4048517A23D2" modified="2018-11-07" version="1" fragment="single">MKVKIPFITTAAVPVVENEEDNKSRVTYNSIEDRKNGSQNDDDVDSSDLQYGVKAVQASNQVWTKNQLVLAYILIWVIHFVLALSSGINATLTPYVTSAFQSHSLTATTTIISSMISGLIVLPYAKLINVWGRPQGFALMVFSMTIGLIMMAGCNNVKTYCAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXF0</accession>
    <name>A0A367JXF0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000588">
        <property type="protein sequence ID" value="RCH94341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXF0"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="40"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="344" mass="37969" checksum="AADAB8342C132D41" modified="2018-11-07" version="1">MNSNNDIPLRGKDRNEAEEPFLPPPVQSKPVEREHPVTLIASVVAFYFVISLSVVFLNKIILSGSTEFPYALFVTWYQLVIALIILVIWAEIGKRNKLFSIIPPYEFDGTIAKRVTPLTVVYVGMLALNNLCLKHVEATFYQVARSLSINFTILFTYLILGKKTSAPALLACAIVFLGFAIGSYGEINFSWAGVIYGVGSSAFVALYGIYVQKTLGIVDNNPWKLLHYNTTTAVILLGIFVLISGEITEIIETSEVIYDVGFWILMTVTGITGFAINIAMFLQVKYTSALTNTISGTAKSCVQTVLAAMIFQNEISGLSCLGIILALFGSGYYSWVRYKERLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYY6</accession>
    <name>A0A367JYY6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase zeta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GSTZ1_3</name>
        <name evidence="4" type="ORF">CU097_006434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000501">
        <property type="protein sequence ID" value="RCH95099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYY6"/>
    <dbReference type="STRING" id="86630.A0A367JYY6"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="24715" checksum="304E53F3F861172A" modified="2018-11-07" version="1">MSEQKPALYGYFRSSASYRVRIVLEIKGVEYDQKIVNLLKKEQFSEEYKKVVPTQKVPAFVTKEGRVILQSQAIVDYIDDVYPGPSLYPKDPLDRAYVREICQIIACDIHPLQNLGVLQRVAPDNQEEQNAFAKEMITKAFYGLEARLAKVSSKYSFGDTLTMADVFVVPMVYNAMRRDVDMSQFPILSRLYDTVSALPEFKRASPSAQPDCPPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K135</accession>
    <name>A0A367K135_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000416">
        <property type="protein sequence ID" value="RCH95952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K135"/>
    <dbReference type="STRING" id="86630.A0A367K135"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_bL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="178" mass="20510" checksum="2FCC0B73C3AA8D80" modified="2018-11-07" version="1">MLYCALYFKKNNFKIALFVCVIMFTTFFKGLTSAANRASSVKQPIQNIYRQVQTATADTPSALEKLRNQLRYYAVVDIAGRPFLVTKNDKVIVNRLNDVKVGDVLKLDKVREIGSKDYTLKGTPYVPENVFDIKATVIEHTKSKLIRIVKKKRRKNYKRTIEHKQTHTVLRISDVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1L4</accession>
    <name>A0A367K1L4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000399">
        <property type="protein sequence ID" value="RCH96132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1L4"/>
    <dbReference type="STRING" id="86630.A0A367K1L4"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="205"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="457"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="634" mass="72281" checksum="146062E04DFF5992" modified="2018-11-07" version="1">MPVASSEYQNERYASFATTSRLITCLVSESLVPVYFIPIKSIDDCDPCIGLCLLLRATSTEQEVETPKKVTIQDILTVVPLRGLPILNQQDVAVWNGVTCPRIELVDNLDMLPHIYSVELSSQFKASGSVKQKTADTLSSILDSNQSFDLIDGYNAVSLWTQFASDLNINSKLREQIGQELQSSIMFQKYTYDHPKSLPSWESSTIKWEQSIVEGHATHPMHKARKSFPPMPPLYPGSYDLDHPNIRLVGIPREKAMLRGNYEELSVPLINALMDAGGNHKEIREQYPNHVFIAMHELQLPNVEEKFKDAIIFSKDYQISVEALTSLRSVARPDILPGLSVKLCLGVKISSAMRTVTPFTTYFGPGFSSDVVPRLTYDHDILIIERELGTITYRHEDSDIAKHCSSVIREAVEYDPQYKDDLFVPCAALVEKIQRPDTDKTLVTHVWNLDTKEKRREFLDRYVDFALRAFLPPCLQNGVAFEAHGQNTLARFDRKTGVLKGFVIRDFGGVKVHNETLKKSAGCEIDVLPDSCVVAETVDEVVKLLYHTLFHCHLQRLIRVLDLHYSGEGWEIVRKYMAHYIPKDHIMWPMFMEPRRVPGKCLVRMKIDELYRDYIYRPVPNIINFKPQSLSETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2J0</accession>
    <name>A0A367K2J0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000374">
        <property type="protein sequence ID" value="RCH96380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2J0"/>
    <dbReference type="STRING" id="86630.A0A367K2J0"/>
    <dbReference type="OrthoDB" id="2325450at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="19990" checksum="18B6A0A84D6CFDD6" modified="2018-11-07" version="1">MKEETGALVQPLVTLEECNMLKFPNAEINLKLELCCSTCVAAFNINGITIHLFFEMADSSQDPNYLRLGEIERLYPKVMLLDVMNDALIRTTQRATAMDVDQNLISVLNKVRVSKFDEDVITFINSRTVLKNNLSQKCLRLYTTRSNVDRAILKEFKRLEGESIYVPAFNIYNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2T8</accession>
    <name>A0A367K2T8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein fmp32, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_014463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000357">
        <property type="protein sequence ID" value="RCH96562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2T8"/>
    <dbReference type="STRING" id="86630.A0A367K2T8"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH96562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23802" checksum="B72345E5B25D6BB2" modified="2018-11-07" version="1">MLRCISKSFHFNKAFKFHTTAYRSQNYFDTFKFVERLEQAGFTRDQSEVIMTCLQKVINESMSDITKVMVSKADREKAIYAYKVDFAKLRSEVQLIERNDFTMMKAENDRLEGEIEKLKQKLKDEIARTQASVRLDLNLERGRIRDEASAQEIKIKETDTRIESEISNLRTQMEAIKFQIMQYMIGTMTGAGALILAYLRMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3A8</accession>
    <name>A0A367K3A8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spore coat protein CotH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000351">
        <property type="protein sequence ID" value="RCH96629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3A8"/>
    <dbReference type="STRING" id="86630.A0A367K3A8"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017066234" description="Spore coat protein CotH" evidence="1">
        <location>
            <begin position="21"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61768" checksum="6FE43337BF4E2507" modified="2018-11-07" version="1">MLFSKISVPFFVTIFASAQAQQQNITYSVISSPPPNMGIAVVVDGTPFPLQANQGILYQGKAPIAQKEYHYAIIESNTVKVPEPFTRGPIQKDTSNEFFNRTLNTHNITSLPQVMTPVPILHRIKSDLHAEGQIPTYHLWGNETAVDYLLKNATEDIDIELNFTYIGLDKIETFEGVKVSLAGRSSRMVDKVSFGIKLKKKSDDTLFGYKNLKLRAMAMDPTYVREKAVHSALKAVGVPASDFSYVRLFINNKPVGLYGVIETFQDPWLASEFKDGDKNYKSGYLYQAILAGMNQQEWQYMSDLSYYDNITTYTLGEYKIKAGPSKDSPQDFSDLQEFTKFIHDASNTTTIDDWQKRIDVDIFLRAMTIENLLGFSDALMTMSNNFNFYKNPEDGRMIYIPYDFDTTLGTGLFEMNLLLTGNYTAFPGLTFRPLSKKFFSYDYFSAPYQNLLVNVTKSLINPTVMNPFFDSVTKMIQPDIEWDMSLPKLTHGAPSPEPGGNMTEIAKIMPPGFLTNWTKIPEQYLPPQEFIAKKSAAVLSFYNQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K402</accession>
    <name>A0A367K402_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000318">
        <property type="protein sequence ID" value="RCH96992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K402"/>
    <dbReference type="STRING" id="86630.A0A367K402"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="79863" checksum="70FA2B5303C9EF23" modified="2018-11-07" version="1">MADSISIEETNALRAKLGLPPLAVEESDEETIDPEREAYENYQRQKEDQERAKREEEAKKKSERSENRKRSLAKLQGKGLGEASDDEDDSALNWVKKSRTRERELAEKRAREIEEMDNTFQSANYDASHLSGLKVSHSIAEFQEGSETILTLKDRSILEEEEDEADELTNVNIEDKERVKKNLEAKKQKPGYNPYDDDQFNGSKKSILPQYEEEEQNEGFVIGNSGVITSKDSDSKEDQQKISQKLKEQTLNYEKMQEIKDYYTQEEMEATFKKPKSKKKKKMRRKNNDDAEDVSAATSQTTSDNTPPVNQSTTSRVRTQDPDANFVDDDDLQEALARARRVANKQKNKLLKKMTPEEIAKQIREQEANEMKTEENDEGGLVLSETSEFVSSIGANIPSFAEDKPVKKEPEPPVIKEEPIDEDISVTYIKPEPADEDMHEANEVEDEPMEEIKEESPVNIKEEPKYEEIKEEPIIEEPLVSGGLAATLELLTQKGMIAKPNEEQLKRDRIAAEQIRWQNEQRKKEHRRMLEEQKEKERRRDHGRDRDYNRDRMREMEREREREREREEAKRLKEFELAMQNYKPEVHLEYTDNKGRVLKTAEAFRFMSHQFHGKTSGKTKTEKRMRKIEEEHRLNMMSSTDTPLNLATALLERQKRTGSAHVVLSVGNRGVVPSTTPLTSEKQKPAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4A5</accession>
    <name>A0A367K4A5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 17">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PIS1</name>
        <name evidence="20" type="ORF">CU097_011335</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 17"/>
    <dbReference type="EMBL" id="PJQL01000313">
        <property type="protein sequence ID" value="RCH97043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4A5"/>
    <dbReference type="STRING" id="86630.A0A367K4A5"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH97043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="25136" checksum="8647B654E7EE6750" modified="2018-11-07" version="1">MTSTAKVMAPSKDNVFLFIPNLIGYTRILLASISLYYMPEHPKVCVPLYCISCLLDAVDGNAARYFGQCSKFGAVLDMVTDRCTTTCLLCFLSIRYPEWTLIFQFLISLDFSSHYMHMYSSMISGSSSHKKISEGQSWYLRIYYTNNIVLFLMCGGNELFFVLLYILSFSGPLNAYWWAALGVTGTVCFGKQFINIVQIVNASNTLAAVDLEERAKGELEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4W2</accession>
    <name>A0A367K4W2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000301">
        <property type="protein sequence ID" value="RCH97175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4W2"/>
    <dbReference type="STRING" id="86630.A0A367K4W2"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="358" mass="40989" checksum="1B4B61F11B2792F4" modified="2018-11-07" version="1">MTDTTYSKNKSPTPSSVGDDFSAAVSWPILLAGVPTLGAFFAGSSEIWSDFIMILLILFYVYKWMTVPWSYYESARIRRVIHQQSSVELKAGPKAEEAAYLHKLQTEREKQQSIHAELRRHELAGLVWIVLSPLIAGYTLRYSRYFFANADKYISAFNVTVFTLAASIKPLSHVILLLQERTLYLQNEAAFSETEVEMLQSRIRFLEKEIDVLRRAYATKKDLGQITEDINPTLQQLTKTLHRFEKRDNALRTWSQQHFTAIEQKVKEFDQYICYRIEQDQRQQAHGVVVSLVLLPLNISLWIAKRMSFWLPVPHKGLLASSSESTCQPLKKPLSKQLPGQIAPLSYSNDESVAAFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4Z5</accession>
    <name>A0A367K4Z5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000324">
        <property type="protein sequence ID" value="RCH96931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4Z5"/>
    <dbReference type="STRING" id="86630.A0A367K4Z5"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="310"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="400" mass="45284" checksum="EF9641A41AFC0ED7" modified="2018-11-07" version="1">MFAPTYTSFDLNGKKILYDTSFDHIARFSSDLYSPMIPPNDYIVNMPGVSDMNSKETDLDLDYQMSEGNTMITKRDAISYLTGELDMTQSLAKFYSLAPFSPIEGDLINYSVCDNAFVSDGSDLDPTAMITTQMGHPNVFKESLPSFTELPSTVISGYNLELPVGFEEQQPYFNSGATTSSLMCCTTQNIVVPEGSISHLPDLAAPDEFISSDEDNNSAADDHDYPDQKDEVTQVTKETPKEAETEKEQTECSDRHLEHSDSQTVIKPVRRKLTNQARTKKHCKSGHIRKRNSKLSKKPSVFYQDQSDNSKRTRKNYDKTVINILMSWYLEHDGKIPDSSAKEDLCKQTGKSIVQISTWFQNARRRYAGKLEAYRLYSIKHPDIVYDSESLDAFLRSKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5K5</accession>
    <name>A0A367K5K5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysine-specific demethylase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KDM8_2</name>
        <name evidence="2" type="ORF">CU097_013884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000272">
        <property type="protein sequence ID" value="RCH97503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5K5"/>
    <dbReference type="STRING" id="86630.A0A367K5K5"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="240"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="390" mass="46155" checksum="D335E00C31C24985" modified="2018-11-07" version="1">MFQQLFQQLKNLFEDRDKTKDSVYALFESARLDVLSRKENCNEKIDALIDYCNETILLYPFKDVPDHWRRMLIDTGLLKTMAQLERCKDVQSLIWDLDTCSIVSGAPERYEIVTDILEQLQKHYHKDNNKDNDMSLASKNDIWMDIKYPIKSMAPPTFEWFLAHCNQDLPEPIVIKGLIDHWPATERWKSTRYLLSIASARVVPVEIGSSYTDSEWRQEMMRFSDFMKKYILTETDGKVAYLAQHDLFYQIPQLERDMIVPDYCYIEPKLNEFYTQRPKDVIKNAWFGPKGTVSPLHHDPYHNLLVQVVGSKYLRLYSPDQTHLLYPRQGLMSNTSKVDVDHVDHEQFPSFKDAHYVECILREGEVLYIPPKWWHYVKSLETSFNVSLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6A2</accession>
    <name>A0A367K6A2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000283">
        <property type="protein sequence ID" value="RCH97371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6A2"/>
    <dbReference type="STRING" id="86630.A0A367K6A2"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="162"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="762" mass="88785" checksum="112DB055EEDDFBC2" modified="2018-11-07" version="1">MDLTPQQEHYFKRELISLELERELDAFKQHPEILSNVIKKEASDYPFLQFIAHRFVLNFPLLQKGDKRQFWSKLQSFLDEYYKLKINNYAPRREDSQRRIMLYKVQRLLNISLSAVIKTTQPEERIQVIRQDMDELATDMSLAHLESEEDYLEWIGMNGIKVNIITVRDVSEVRTIREHVHSEFIIETRTDKVVRVARRHGQFRQLRDDLKAAFPTADIPTVPSKAHDTNVQVSCLHREKDRILLRLFLRRLAAIAVVAESEIFYNFLTDKPIELTKDEEKDRDEREKMDMNRRKEEKRFREQVDSKIVELDALLNLLKQKVMQPNGLLDIFETIKKTEKIDQLPVELQKAIEWGRINLAFVLHTQFVTSDRSVENVANLKRTHSLIPYRTMAQILKLSNPFAMVKGVLDLFLAQPFGGKSLFQRIILANMSEESKEMQKDIQELEVKINDAALCQKISNAVKTEMPIDIEAGDDPISETLELLKNPAIEPVLRPDQILKVAFAHQQDAPRQLVMYLYQLWVLYAKKQEQETLMALVFQGVTGELMKDLFAIFYEPLAEVYKAANIGDTIGHVSHFIDDLIQLIDQLDAQDATNTAQPFIDLVQRHEQQFYTFVHRVHAQDHSRLFDSLLAYVNSIFSLISHGLPTRVDLNGCVQDALTPTEYPGLKAEIDALCLYHKERKERHLERKRQKLMMTIDDEDELDFVPGNKEFMSIASEFADMDDDIDDLLPKHEMNLRRPKLQLVPKVVPFFLRRLAHHGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6J7</accession>
    <name>A0A367K6J7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000241">
        <property type="protein sequence ID" value="RCH97882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K6J7"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="607"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="798"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1382" mass="159213" checksum="018F4946E02AC768" modified="2018-11-07" version="1">MADNETKSLTIESNISNKPSDMTRQDIFMIQYSMKAINSNTAFSTFKQELRYPRSILTFKILGKIGGIQHCKDWIHYVDHVSNDLGPWCSDILWSILLNDINPGSNEFSANDSVLLQQAQIICRHTFEFSTFDYRNTELFTPKVTQFINCLISLTSSNRRLFTVVIVENRITALVLKLLISSLDVLRTGISCDVFLDTFENISETTEGPIPRYKANQVNLLITTYELEAIAITELYDYLIRFDFYKDERMYLASTAIRRLSSKTIMLINAQDKREMRLANKIAQLEGRIANVHHFSSSSTDTQMPSYPKKTNMTEMKITKVQAGSYKQSRVKFWESDIIAKMEGLEIMNPENEESSVFWLSAFEIEQPEMHTRKIGFCTKKPLPDLPTLEFMLDNTLHKFHVRNFHTCVHLEHSMSDQLLSYTLQVTNHLKKDNIKCSLDDVPYLLVPLKQFCNDQSHDVDVDWEEIEKTIKCSTKRTALSTDFPISDTLVYDLEKPSHMFLIQDMPVSIKPMLCLFRDSEIGDQEKFVFTEFYKSRLQHISKMDFSKPLIQATLVKRASKKSSCLFPLYSRAWLIPDYCAIYPISASVYRTYELLPEIMTQINAYLLVLQAKEMYDFEKIDDALLREALSCKNADFIKDYERLEYLGDAVLGFIFSTYLYIKYPNYNECQLTNTRTRVVKNSTLAQAGKNIRLYKYIINQKMDRDAWQPPAFTSCYKKRKSIGFPYQTTRRSLSDSTIADVMEAILGAAFLSHCLDGALHTATKLLLPFDGLKTWSDMSDLCSKITYFPERVYNIDLAEFYRKIGYTFNNPILAEKALTQRSCKVSLQYERLEFLGDAVLDLFIAQYLYKKYPTAPPGELTDLRSMYASNATLAFICIKMDLQKHIRHSSPEMAVNIACYENQLRENAMKEKNDDDFWLSLDPPKVLADVVESVIGAIFIDANCDPQPAYAFFEAWFIPLVDGHVPGMAFPIVKFQSAIRGFRCHEWELRYVTIEKQNQTAEFKNIPTVLGKVNPYNIIILGKTDLYLNKQFNFSHFIPMVTTVTAAALKDFCKQLPKVELHAHLNGSLSPATMKKLVEFKKDTNPELSEFQIPESLASIDDFFAIFSFIYKLTDNEEAVKLATRNIINEFAEDGVRYLELRTTPRQNAKTNMTKMSYIEAIVSVLQEPRDDIIVKLIVSIDRRNTLEEANEAVDLALAFRSKGVVGVDLCGDVKKGSFDALKPAFDRAKEHGFPVTLHFNEIVENLSEAPSMLAFKPNRLGHATFLDDYCRKTVYENHVPVEICMTSNLLCKTVKTFQDHHIKELIDDRHPFILCTDDKGVFFSDLSNEYRIAAETFNLTYSELFNLSYRSIDAIFGDGHLKNQLKNMWLAWRKEHEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7R5</accession>
    <name>A0A367K7R5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000214">
        <property type="protein sequence ID" value="RCH98218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7R5"/>
    <dbReference type="STRING" id="86630.A0A367K7R5"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="425" mass="49029" checksum="BCD28B71B697394C" modified="2018-11-07" version="1">MSTMVDNGDYPLERTISWQDIRDAPLLSSRHSQNDQGYIYVDSNNRKYRKPPVHFSVNITSIDGDPHKKTCQPGSTVSGYVQLNLDSPLAAQYLKLLFRATEHIYKDNNKKVRERLFSIRTTLWGTSSISDYQWPMLEPGKHRFQFLCELPLINYPPSFRHHLASCEFEFLASLERPGIRPFQTVPVFIRYQPLVLTSPLKSPRPHREETVFNNQTVTMILPKGCNYNINDYTHKSTMDVHLSFSQHTPINHIEAIIKREIHVSYGSYQQTDTMVMSHTDQSSFYLQQTRDEQLHYLIQVPMPTEHNKFNSSAVQRNFSVLGMTTSLVEHSKHTRIIYKLVITAKIRHGFLYQKRTLFSTILQIGTLPHGVQVPSNVVSYTTITSESSTSATRPRFLYVPDIGEEQLPAYGEEPSPPKYSSCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7Y5</accession>
    <name>A0A367K7Y5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RHO1 GDP-GTP exchange protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ROM2_13</name>
        <name evidence="5" type="ORF">CU097_013956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000205">
        <property type="protein sequence ID" value="RCH98334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7Y5"/>
    <dbReference type="STRING" id="86630.A0A367K7Y5"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="310"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="685"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1000" mass="115289" checksum="82A4B94BA5C85AEC" modified="2018-11-07" version="1">MSRLSSVMRDVNTFISELDQPSTSPPRSQSFQQFSNAEYQKIERSNTTKTLVNHKFTEEEACLSFAEPSQKRVQQSCMSPENDYVNRYLKHKDEKTMVETRPLMSSTLSTGTSVSTVVPSNYAYLSALSEAFVKKIRALESIRELFCANVYPESFTGQEAINTLSNLLDGLPEPYCVCIANTLMKTTPPLFEPIHYSQKSIIQGSLYPDEYYTLNEDMTDEMPQGILTGLLGCYTPNCHPNEGCYTPRCPNRYPLAFLEPFGNQELKAPKGTIGRTPSSSSHMEQKALSEAWAQNVPKELLETLSKREIARQEAINEMIYSERAYKNDLDTLNDVIVRPLLKDSNIIPSKQRREEFVSEVFGNYRELRELSLGLSDDLISLQQEQAYVPMIGDTLIQHMAYFEGPYTRYCSRMSLAEYLIKQESKVNPRLAMFFIQVEQDKRMRRLALRHFLLSPVTRMQRYPLLISAILKKTDTDHPDYTFLTKCLDMIKSVASRSDQMAEYYKRRVEILETNDALVFKPGNPHVDLELTDPRRRLFYQGIMKRRSYEKSDIFLFVFDHMVLMTKYKYRVWKKPIPIQMLYLSQRSSQTPPVSTATSRSLMPAASSNNNVASPNYALLYPLTICHLGRHGGAYNFLCSLEEKQKCIQAIEEAKSCLRKRMGEEVCELISLDDSSFRYSATTTLQGKVCCTFPFVTIHMEKILLVGTDNGVYIKNYDGTVRRIITCEEVTQLAVLERHHILLILAAKTLKAYPIDLLMSNSKSPDKLGQTLGQHIHFFQIEPLYDLRDSKNQKYITPKTGFKLGGRSHHAWFKKYKEFYVGAEASRIQFLKSKFLIVCDRGFEVIDPENLAVGGREIPDRMDPQFNFVSREMIKPIAMYRVHDKFLLCYDKFAFFVNNRNGSLVYRGPQKLPLLCEWEGQPMDIVFQYPYVILFDAQFIEIRHVDTGELVQIIPGDQIKLTYFQTGDTAEIHGCMTHMIRSDIQQLFYLKLKAYHPRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K812</accession>
    <name>A0A367K812_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000203">
        <property type="protein sequence ID" value="RCH98363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K812"/>
    <dbReference type="OrthoDB" id="5573882at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="246" mass="28667" checksum="88AD1AA0B752EF00" modified="2018-11-07" version="1">MLSKTHPIPTPYGHIPKYRKKKRNTTVQAPYPFFSTSSTNSFFSFLSSLFTSKKEQVGFMPIHNNKPQIQTITSTEPIDCHHHFNQEDTPSLSTSLSSSESSTTSSNQYSLSDIDDNTSILSDILCDHYVYKQQQLNNTIKDDNVPLETFRLFEAPLERENDRQQWILVEQSEKYSEKKPVNEQTIRQHTRDIRTNTDYFRMIVAEVNMMRAQKIVCPLRQRRVLPKRNDPFKIRSSPLQNCIICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K879</accession>
    <name>A0A367K879_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000197">
        <property type="protein sequence ID" value="RCH98433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K879"/>
    <dbReference type="STRING" id="86630.A0A367K879"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="135" mass="15941" checksum="C939EFE697B23791" modified="2018-11-07" version="1">MSNIRMLNEKEEADGDVEVTWIDQERINEFSKYNAKIDDFEEEYEKLKKEKEYLDDVAMELELADEDEPVRYKIGDAFVHISVSEATEKIEKDSERLDLLIEEAKQNIDKVQEKMDELKKLLYAKFGNAINLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8C8</accession>
    <name>A0A367K8C8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_014915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000198">
        <property type="protein sequence ID" value="RCH98426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8C8"/>
    <dbReference type="STRING" id="86630.A0A367K8C8"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="432"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="662" mass="77221" checksum="BE5AFDE7150BEAED" modified="2018-11-07" version="1">MSTCLKRKRWAMKRSRNIISPAKEKDVQQQKELSVSSDSMMIQLSSPVKQLFPSISMFNLPSTNIPNTPPHEAAKVDPPPQFAIDIDTAERFKRQCKKLYIKRHLQEAYPSAFETYLFDDTPPGAPPSQGIRPVRLLLERLEAWHLLAKRLLYHFEILASVEAKVAKQYRVLDDVMIFPSPSDAPPEEHNYRRRPMITRSQRQKVFFKDQRLLQVHFNFAGGIRSVCDTWQTYHSNAAKDHAEFATFLRSKAISTLSNIKQELKWMIEAIHSDDRLSLDTLTSLKREASKRLKRLDRQLLFFDKHPFYAYKKKDPWLINASVVKQMVKVYRQENKIHETVLRLQKEIHLSEEQLVEEFKHLCQHIYHMRSQSYLGVDRGLEAVLKAFENIKIDSDWMNFCQQHHDHLVSEKAAFRNPDLLQYPNHNHPLLQPIFAARMERRSMVLHQWQEYIYVLTPAGFLHEYRDGRNYPGKPDETLFVPHFKVSTLSTNLHHSLIFQLQPHAASRNILNSYPAPRDWRTPSTSRLNRALSNRLTWTFRAKSAADMERWIEELTLASESYRPFLPTANGYREQEEPQNEAETTASEESTEEKGDEKIEEQAEKAVKEKVEETVEKSVEEQLPNEQEEVKEEAPQEPAPETPQEPVVEPATSDTTQPEEQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K994</accession>
    <name>A0A367K994_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000175">
        <property type="protein sequence ID" value="RCH98736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K994"/>
    <dbReference type="STRING" id="86630.A0A367K994"/>
    <dbReference type="OrthoDB" id="2280912at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28979" checksum="BFD569C60914E584" modified="2018-11-07" version="1" fragment="single">FIDNYVENHPTCIVKDVIDCLCAAFDDLTINESNVYRHISDKLQFTLTRTQPRIAERNSEDTIEKQNAFLWMKVDLKKMVRPVGWSKKGTPVEVEVQQEGTNLSILGCMSANGLIAVSQQVPKSKGYKKQKIAGTKRTLPHDTKSSHFLLFVEEMASTLIKLGLHNMHIVLDNATIHKIEEVVTEILIVDTYSPLDYDRGSIFSNTTIQYKLNPTILNSNYHNSIPLEIPNSPSSSDEETNNPIQAYVLDHYSLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9D3</accession>
    <name>A0A367K9D3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_015042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000172">
        <property type="protein sequence ID" value="RCH98776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9D3"/>
    <dbReference type="STRING" id="86630.A0A367K9D3"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="355" mass="38360" checksum="B0051BC9CF56BA79" modified="2018-11-07" version="1">MGKDYYAILGVPRDADDETIKKAYPLKWHPDRNKDKADVAHAKFQEIGEAYEVLSDKNKRAIFDQYGEEGLKGGAPPPGADGGAGGFGGFPGGTFHFSTSGGPGGGFRPSDAEDIFKHFFASFGGGGMDEGFGGMGGMGGMPGGFSFSSGGMPGMGGGFRRSGFRQQQQQAQEPEKPPAIKRPFPVSLEDLYKGCTKRLKVTRKLRDGATGRPVQTDKILTINVKPGWKAGTKIRFPGEGDELENGTTQDIEFVLEEKPHSVFKREGDNLRMTIQLTLVEALTGFQKKIKTLDDRTLSVNNTKSVVQPGQESRVAGEGMPNSKTGKKGDLIITYEVKFPTSLSDDQKQQLKQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9M1</accession>
    <name>A0A367K9M1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_015152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000165">
        <property type="protein sequence ID" value="RCH98867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9M1"/>
    <dbReference type="STRING" id="86630.A0A367K9M1"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="446"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="795"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="915"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH98867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="958" mass="107952" checksum="07657519BF884105" modified="2018-11-07" version="1">METEFIDFNSGLILKPGKTYVAYRLRGREIVAGTADARVTIFKTDKDIRKVAEASIERHIDEVSCIAIHDNRFASAGTDGFVIIYNNNEYEKILIRSTVAVRSIVFHPQGTKLAIAADDNDIRIVLVADNSKIVTLQGHTTSLKSLDYDPTGNYIASSACDGEVRIWNVGPSEPAPRCIKTLKDATPPSKPDHALSSKVSWSPDKSCFAFPGKNNDICLCSYGSWTTTSILGNGHTETVSTFSWSPNGYYMATTANDKQLIIWDIKNRKMVRKTIVVTAITDIAWHPTENQLIFANESGEITYWDDVIPEGNSNYPHPAKARKQIQNREESIELQSQEPYSLEPSSLDPQSIEPHSYDSRKKERNRFFDTMANVDEDDDEGEDLGSEGDDVDMMDAEDDFIIDDDGAGYVETAEERQKHQQRLNLSNVHRNGVAYQKPVVFVPPTTFQPGETPFNKLGNNRQDAAEGERRYLCYNLVGAMYTIHQDNHSIVNVEFHDQSTHRNFHFTDYSNFTMGALSEGGAVFGVEGEEAPKKEKKTKTNDDGEEETDYEEEEEEENEDTSKASILHFRPLSMRAGGEKDWTYHLPAGEDVVAVAINNVSVIAATSAGFIRIFSLSGVQKHIFSLSNIVTLSAMNDLILFVYASCPSFTNQQNLDYILMNTETNEVLQKDKIHISGGSKLTWAGFSETTQAAIYDSDGILRILHHQRRPNQGSWVPVFDGRAYAKSVQKSETYWPVGLLRDRLMCVILRGSNQYPYFPRPPVNEVPLQLPIVEPESETGKIEMDYLLTLYRDLHERDEAEATGKQDEYQDTFDSADIEMDKDILRLINIACKSERHSRALDLVNSLRLSESVDKAIRIASFHHLSSLANSMMRIKELKFMANTRILPPSLTESLASQPSLYGSNVPSLENSLSLLEKDEKDTRKRSIFDETEDVSMDSHEDNSQRMKKPRPFQFSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9Q1</accession>
    <name>A0A367K9Q1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_012740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000156">
        <property type="protein sequence ID" value="RCH98972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9Q1"/>
    <dbReference type="STRING" id="86630.A0A367K9Q1"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF58">
        <property type="entry name" value="METHYLESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016696060" description="pectinesterase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="36273" checksum="988CFBE88C16E859" modified="2018-11-07" version="1">MQFSLGYLTLALLCIQLVFAGTISVCNSCQYKSISKAIASLPNNAESYTVLIAPGTYTEQFTIARSNLVLKPASGTVIIQYASGHDPNAKTGSTADSAVLTITGKNVMMQDIIIANTLKQTRVANVALHVNAPQAYFKNVKIYGFQDTLLINRSGSAYFKNCWIEGSVDFIWGFGTGYFDKCVIASNQKGTSVTAQGNDSANAPGGFYFNHCVFKATVPSGPLSKTYNPSMAFTSSSQFPDSCYLGRPWRSYARVIIMNSDLGNHIKPAGWSEWPTSTPDTRNVLYGEYKNFGARPWTSARVKFSKNLSDNQAAQFTAKKVFGGNTSWFQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD74</accession>
    <name>A0A367KD74_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1264-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000101">
        <property type="protein sequence ID" value="RCH99771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD74"/>
    <dbReference type="STRING" id="86630.A0A367KD74"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25507" checksum="AD800389212832C4" modified="2018-11-07" version="1">MCSEQGKTSTLKAGMELASSPLISFKPMSGICESFCGIHPYCNDTSRQVIAYHYCHMIDEDRRQCLVYDSDSVDAKLIAVEYIISEALFKSLPEQEKKYWHSHKYEVESGLLCMNVKSLVPDAVTSTIEKGPLEILVNTYGKTWQLWPVDDDGNCSSKVPLGPPQLMMSFTADGQVKPELVERRDKQMGISTEKKRAERKDVIKGNPVAEGADHWEKGKPFQIPTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDZ1</accession>
    <name>A0A367KDZ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA topoisomerase I</fullName>
            <ecNumber evidence="9">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TOP1_1</name>
        <name evidence="13" type="ORF">CU097_007405</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01000060">
        <property type="protein sequence ID" value="RCI00435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDZ1"/>
    <dbReference type="STRING" id="86630.A0A367KDZ1"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="12">
        <location>
            <begin position="319"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="793" mass="91601" checksum="4EF49CC6CBDF798A" modified="2018-11-07" version="1">MSAVLSDDEIPLAQRVKVGNQSNPSLPEPRVEKNEQMNGESSLKESPVKAEDSDDEDDIPLAQRMKKSPIKTEDSDDEDDIPLSQRLQKKANGKLSPVKKETNGDHGISIKEEKVKPEPMEVDMPSKKRPLEKSASTSTKNTKAKKKAKKEEEEEDIYKWWEEQDQSGIQEDDSIKWTTLEHNGVMFPPDYVPHGVKMKYDGKPITLSPEAEEVATFFANILESEHAQNPVFQKNFFNDWLEVLRKDPSNPKITDFNKCDFRPIWEKLQRDKEAKKQMSKEEKQRLKEEKKKIEEPYQTAIVDGRREKVGNFKIEPPELFRGRGNHPKTGKLKMRVQPEQVTLNLGKDAKIPEPPKGHKWGGIVHDQTATWLATWKENVNGNIKYVFLAATSAWKGQSDMKKFEKARELKNCVAAIRENYTKELKDKVSEIRQRATAMYLIDRLALRAGNEKGEDEADTVGCCSLRYEHIELEPPNILHFDFLGKDSIRYQNTVEVDAQVFKNIKLFKKQVGPGHMIFDRLTPNGLNKHLNNYMKGLSAKVFRTYNASITFQQQLDKMTNPDDSIHDKLLSYNRANREVAVLCNHQRTASKNHEQQISKIEDRIRALKYQRMKLRKTLYAADPKMKKNPKYADPESDLEEEWMIQHEADLVTKEKERIKTRFQKQNEKLAAKGEPQLEESELTKSLKAADALLDTFAKERKAATIEPKNSMTADKLIARIEKIDERIAATKVQATDKEENKQIALNTSKLNYIDPRISVAWCRKYNIPLEKVFSKTLIEKFRWAQKIPDDWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEC1</accession>
    <name>A0A367KEC1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GFA1_2</name>
        <name evidence="13" type="ORF">CU097_015162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000052">
        <property type="protein sequence ID" value="RCI00583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEC1"/>
    <dbReference type="STRING" id="86630.A0A367KEC1"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="364"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="536"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI00583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="687" mass="76648" checksum="2F404F5692AF3F2A" modified="2018-11-07" version="1">MCGIFGYCNFLCERSRREVTETLLNGLSRLEYRGYDSAGIAVDGDNEDAVIIKQVGKVAALRKLVDEHPFDFDKPFISHCGMAHTRWATHGQPSQINSHPQRSDSTNEFTIVHNGIITNYKEIKLLLEKKGYVFESDTDTECVVKLTKYIFDSHNKDLSFTDLVKAVVKELEGSYAFIFKSKYFPNEVVSTRRGSPLLIGVKTAKKLKVDFVDVEFGPNPVGNDANFSAVEGQDMSRPALNRSQSRAFLSEDGLPQPIEYFLASDASAIVEHTKRVLYLEDDDIAHIADGELHIHRVRRSKEDNTPATRSIQTLEIELAEIMKGSFDHFMQKEIYEQPESVVNTMRGRVNFENHEVTLGGLRGYTHIIRRARRIMFIACGTSYHSCLATRNIFEELCEISTQAELASDFLDRASPIFRDDVCVFVSQSGETADTILAMRYCLERGALCVGITNTVGSSISRETHCGVHINAGPEIGVASTKAYTSQYIALVMMALQLSADRTSTQKRREEIIDGLYRLPGHIKEVLAIDNKLQKLAVETLSQEKSLLILGRGYQNATCLEGALKIKEISYIHSEGIFSGELKHGPLALIDEHMPVILIMTQDSLYPKVQSALQQVTARKGNPIIICNAGDQNLANTTYKTIEVPKTADCLQGLLNIIPLQLLSYHLAILKGVDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFB5</accession>
    <name>A0A367KFB5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000034">
        <property type="protein sequence ID" value="RCI00914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFB5"/>
    <dbReference type="STRING" id="86630.A0A367KFB5"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="121"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="408"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="538" mass="61354" checksum="8ED87F343E62A88D" modified="2018-11-07" version="1">MRSKKSKSNNNEDTNVRNNQSNALNFIKNRLFQSNNYQKSLERQSLSLTTQPLVIPQQQQQQQQDKPLSRSFDEQSISDLTDRDIKNQRPMSMMGIDKLLQEDNKNLIGQPTNNEKRKSLIVIKEGYLFKKTDFRPFHKQAKLDRGWKLYKVVLRGHKLYLFKVTAESPLRSLFPSSPSLSISSSSHDLSTAASLKLVSSEFDRDAQQILFYNSIDPAQGQIFMELNPVNMQAKRSVQLVIHNGCLYVCYRPDKKQLWTIEEKIPIQQLKLTQINSITDLVDSPTSPSSIKSHQSDPSYQKQSSVTLFNISYVNKPFTLGVYSTQYHYAGQAWIQLFQNSNQRKPPFLEEDLFSSKSNGSIEYYESLHPSETSINATIPDLEPSNDSRMYDATQRHHPDLLHKLQLDDDEIILGGTVTALVQELLMTDNEEYVNTFLLTYSTFTAGSCVLDEIKAFLTHSPGKFDNHLLDIFSVWCNKFALDIMGDVATDIISLLDHIDSIDTSKIKELVLNTVAENAKNTAFSETSKLMLVSIRVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFF9</accession>
    <name>A0A367KFF9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000037">
        <property type="protein sequence ID" value="RCI00860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFF9"/>
    <dbReference type="STRING" id="86630.A0A367KFF9"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="21251" checksum="6060CD5D2C1C5F94" modified="2018-11-07" version="1">MAYGEADSYQGGQDFYPKPDVSQVSRLAKQHAQYDDDDDDENGVFSQALHNVIGRDDAKKELDEDTANHAANAHNQIYNENNGQPAQEHSSRDLGSAAAMQAFKMFSGGGSSGGGSGELIAMAMGEAQKLFKSQGQGGGGANQAEMLQTAAMVAMQLLMTQQKGSSGGGGGNLGAVMGVLQSLGGGGGKKQESGGVSGTISNVLGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFL5</accession>
    <name>A0A367KFL5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000029">
        <property type="protein sequence ID" value="RCI01006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFL5"/>
    <dbReference type="OrthoDB" id="2220585at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="254" mass="28803" checksum="9F169E5635912FD7" modified="2018-11-07" version="1">MNTEVRAPGEKFDIEEHSLSHYIDASQLGSRAVGNDNRMTKGNKSPERRRSSISTAHIESSLVDPSNEYAIFAYDQFAAFCADLLLIKPVIDDTVTSFATNILTIIASPTFDLDMQELKRRIEQLLPPVSSVTDEGPKYKYCRGAQLAWLDFEQLYNMAERVVNCSKAGSGLTIVDEDDGEEEDESIETRDQTRRMSVKGDVQYIHQPVATQITMRQTTEDAYPNFVEHNREDMPPDMQYDKDITPFDSEDENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFL8</accession>
    <name>A0A367KFL8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Zinc transporter msc2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_010250</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000032">
        <property type="protein sequence ID" value="RCI00941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFL8"/>
    <dbReference type="STRING" id="86630.A0A367KFL8"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000002">
        <property type="entry name" value="zinc transporter 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="16">
        <location>
            <begin position="48"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="17">
        <location>
            <begin position="285"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI00941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41004" checksum="461E0ACC3BE0C1BD" modified="2018-11-07" version="1">MSAERTPLLFPVNSQTGGSVVSYTVTQKNCKNVTLKDRSEAQSTKRKLWFAVALACVFFATELVAGYFANSLALMSDAFHLLSDVASFIVALVAIYLAEKPPTKRHTFGFHRAEVIAALVSVLTIWVLTAFLVNEAIQRIKSPQEINAKLMCITATIGVFVNIILAYVLGGHHGHSHGHSHEHSHDNDTHSHDDEEEANRNDISAPHRETNINLRAAALHVIGDLLASVGVLISSIILIFKPDYTIVDPLCTFLFSILVLYTTYHLVKDSLAVLMEGVPGNIHPDLIEESLLGVPGVIAVHDLHVWTLSPGKYSLTAHIKVDHTADISYDEVLSKGQHIVCDVYGVHHSTLQIESDKTAFTSHCTPEICAPRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFM4</accession>
    <name>A0A367KFM4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000030">
        <property type="protein sequence ID" value="RCI00988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFM4"/>
    <dbReference type="OrthoDB" id="2281642at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="28339" checksum="EE4472618BE1F837" modified="2018-11-07" version="1">MPSILSQYQQRRDLVYYYNKALSYWIGLLVFSVLNCIDKMSSNEVYSMTGVTDVNLLAEVGNEAELFEIYKVYLDNSYIKDWKVLKIFQDTIQKFYSDDYTQAVDSFKNSFKKFLNDYSSPDKRQKLAIEKMKNNVGALLASKPAQVAFEKRRSGGLEELYGAHTKNSVYQDKITLVDSTNIKNNAGPSTSKPQPVPPNKKRTISKPKTRSKKKTKRLEVRDIKHLPFDQKIHTLVDNLTIWRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFU5</accession>
    <name>A0A367KFU5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromatin structure-remodeling complex protein rsc9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RSC9_3</name>
        <name evidence="7" type="ORF">CU097_015869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000026">
        <property type="protein sequence ID" value="RCI01086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFU5"/>
    <dbReference type="STRING" id="86630.A0A367KFU5"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="684" mass="77825" checksum="8C00F855C4878B58" modified="2018-11-07" version="1">MSQYNQGIERTPEYVKFMKDLKEFHDKKGTVLQAEPVLGGKKLDLLRIYKTVMEAGGYEKVTLNRGWKQVGDPFNFPSTCTNSAYILKAVYTKYLLGWEEENHWKRPWNPPAELLATHQKPTASPMPLPPSNHSRQTGTAFSQPAVITNSQQPPAYHPQATFIDYEFRTRILLSLQSNLPNEVDWAFNTLIKFSFVSENFNLDFIPTLIDLLLNFTAPFFEREIDESANDNMTSKARQETYERVLQVFHIIRNFSFLEMNIRRLALHERLRNILMKGISLAPSSKYGELSRHCLDIMENIAPQVILTSRTDSYLTTMTQLLFSTDRAFILGAIRALTRVAVTEANERILCHADPKVIEHLAQLLLVDDEELEAATLEYLYQYSSLRGSFSTQLIEHYPGNLIGLLTGYLSYKSSLAPPSSTALGTIHGIPAAQMIHVEPVQQQPSIPDLTNYTNLDEPYRCLGWLKDQLTTGGAEDKIALNEIFGSYQKLFGTEKPLGIKEFYTVLKIAFPQPASVEEAFANGPKSLETVLCNVKYNPTRRKDGSICRWEGCEQSFDGKSDLHRHIVNDHLETANECKWMKCSKKGLEGKMNAIQHMRTHFAGKVSKQGNRPKTFTVSKMPVDDSEVSGIPLTSALLLRNLARHKQHHIYYLPYQSELILLAIQRPKVSKYILTVLEEINSNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG55</accession>
    <name>A0A367KG55_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000024">
        <property type="protein sequence ID" value="RCI01121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG55"/>
    <dbReference type="STRING" id="86630.A0A367KG55"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="380" mass="43968" checksum="499202790DFBAAC3" modified="2018-11-07" version="1">MVLTIDDIVTHFVLSSHPRNRAIVDIKEKKTNKLRYIKIRHRLSIYAVSLVSPITFDVMAEVQAKNASTKSKFIILHFETKPDIQVELRETSRIGFEWTFIWEGEKYRWVRESRMSNNLECRAVRKTGDICVAQYLPRVLKDEYFGIISLLGYNMLRCELSQSKELELLLFISLITLLDKSDDASWKRDPISKGIPQEDMLRSPVSERVQQKKQKMERSNEQKLQFMLDKEVRRSQKQIQADQKRYPASAGNSPAHTPKMSPMPTPTTSSNSLKLAKRRSVAQSSDNSPLITPTNSSNGSGTKRLSKLFSSLANVKQQQQPQQLSTDHNRMSIVFPVIDQLREDTYDHQHTFPYYSYSLYGKSNRTRSELMSHWSKSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGF7</accession>
    <name>A0A367KGF7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000033">
        <property type="protein sequence ID" value="RCI00932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGF7"/>
    <dbReference type="STRING" id="86630.A0A367KGF7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="12768" checksum="25A59366448A218E" modified="2018-11-07" version="1">MTHQRARLTKSKSASSTTALQTLEITTTAVVTDNDQTLEDVDSRKQLHHHHYHHIRSPAFVANSSPLPSPEQLETTELLPSPFKCTSEAVVALQDAVKGKSFSLLTLQRTYNCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH63</accession>
    <name>A0A367KH63_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FTSJD2_2</name>
        <name evidence="4" type="ORF">CU097_015955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000005">
        <property type="protein sequence ID" value="RCI01556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH63"/>
    <dbReference type="STRING" id="86630.A0A367KH63"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="462" mass="53577" checksum="44F59D4B09F02B66" modified="2018-11-07" version="1">MEDLYSDNDPHYRETRVPSGIPPPSLRDLKRSEDLSRYNPALLRPMNSRDNNNNNNSSRYQPYPQEEDISRNRRQQQQQYQQQQQQQQQYQYQQQQQQKKPMYKPKPLNLQPSTSFLKCQTRLSVNEIIDLIKLKEVEIDYDFVCSKVQVENVIQLKGKSSHVPKEIVSQARSKSNPFERIGHGVFMNRAAMKLAAMDADFGLTATKGSNQFKFLDICGGPGGFSEYILWRIHSWGESCHGYGITLKMPTEKDEMNWHTEKFRVDIPKDSFTIIHGQDGTGDLYKPENIRDVESLISKETQNGVDLAVADGGFDFSGHEAEQEQLAQKLILCEIITMLSTLRQGGTFVCKFFDMFTEFTVDLVWLLYQLFDEICITKPLSSRPANSERYVVCRNLLVSHPTDLIEKLLDIAAKIGDKQFQFISRDILDKDEDFIDYVRMRNIKFIVQQTDSLEQFDMFIQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHF0</accession>
    <name>A0A367KHF0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000004">
        <property type="protein sequence ID" value="RCI01579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHF0"/>
    <dbReference type="OrthoDB" id="2282637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="16975" checksum="5B0702BDD35ED069" modified="2018-11-07" version="1">MDAIVADTFSKWYIYLYDSFGVQFHAPPPTQVFQCVSNLFNILYIHSPPIVRTYYNILNNIPVQSDIIPIALAMLILYALFATVVMTIRGIVRLVYGFIRFSMIISIIAAMICVVLPYVNQLERNSLFNFENFVFSASPTHTLERQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILQ0</accession>
    <name>A0A367ILQ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005039">
        <property type="protein sequence ID" value="RCH78602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILQ0"/>
    <dbReference type="STRING" id="86630.A0A367ILQ0"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="74" mass="8005" checksum="2A312955D616FD68" modified="2018-11-07" version="1" fragment="single">MFVSRPFPMLKRAMSTLTRIETKAAPAAIGPYAQAIKVNGMVYTSGSLPVVPETGHIVDGIKEQTKQSLLNMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMM9</accession>
    <name>A0A367IMM9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004939">
        <property type="protein sequence ID" value="RCH78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMM9"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="188" mass="22083" checksum="4D0E58461D0C5B65" modified="2018-11-07" version="1" fragment="single">LLTELVHRYPHHQYYEFLQKSLDSLQSIDGEQQEEEIFQDAYSPADFETKDHFLNQIDPQYITQINSPPFYHKPYRRPSDQDYPLTPITSPGRAISSSHENYTYPADYLKQQSDIVSEADTLDREVAAATSRLKKLQTEVTALTEQIDRLRQQHRQHQQKAGWTMQRIVMTLLKHALADFTILFILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN23</accession>
    <name>A0A367IN23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004711">
        <property type="protein sequence ID" value="RCH79090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN23"/>
    <dbReference type="OrthoDB" id="2206158at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="85" mass="9684" checksum="2714140B77900BD2" modified="2018-11-07" version="1">MSSPGYNFLWGVCALMLVIAIILAFKKGKKADRHTVEADNTTPEVVVVSHNEQRPRIHYPNSNSDFQLQPPPPSYQEYQKDVRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN65</accession>
    <name>A0A367IN65_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi to ER traffic-protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004805">
        <property type="protein sequence ID" value="RCH78941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN65"/>
    <dbReference type="STRING" id="86630.A0A367IN65"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18715" checksum="6A1EAC99CBF0E33E" modified="2018-11-07" version="1" fragment="single">TDHSAALLGALAYEWATEEKQTNKGFFLARIVLQYVASKDIHYANLAFTNFIKAGSQPKVAESKVRRAPADEPTPVDVYSDSWINFTQLVLLTVQRDASDLFQQLKLNYQGLYGSEPHFIELMDDIGLVYFNIPKPKKQANMIQEMMASLFGGGSGAPQIGSAPKVDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPA8</accession>
    <name>A0A367IPA8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-zipper-like transcriptional regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004560">
        <property type="protein sequence ID" value="RCH79341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPA8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20112" checksum="BC9128D4A185606B" modified="2018-11-07" version="1" fragment="single">GYAMHLINHIIIFDSYDNTWQKLLDFSGEKQRADGCAVAVPSDTGDTVIVSGGEAVKTSPAVIGNKTKRFKTCSILHFIPDLGLSLTANQCTLNQIPYEHSATLHPGSGIIYYFGGRNHDSKGYVTVASLRWEFIFDTKKMMWGQNNYTASAGSQLPSGRNGQTTVLVPGSQHIIMYGGHNDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPC7</accession>
    <name>A0A367IPC7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004448">
        <property type="protein sequence ID" value="RCH79515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPC7"/>
    <dbReference type="STRING" id="86630.A0A367IPC7"/>
    <dbReference type="OrthoDB" id="2204753at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="77" mass="8830" checksum="8DF7137C559FD4CB" modified="2018-11-07" version="1">MNHALTYGLWNPLSQAAAGVDINDIVTLGNRVSSAELAQRYHREQLSHFDFANIVLRIHDDDDEFHDAESKFDQIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPE8</accession>
    <name>A0A367IPE8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 21 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004433">
        <property type="protein sequence ID" value="RCH79535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPE8"/>
    <dbReference type="STRING" id="86630.A0A367IPE8"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18271" checksum="96946605330BFD45" modified="2018-11-07" version="1">MPVKEFNQPYPVIDTDPHFSRVVSYFRPSDYAAWAAGTAAAPALLLGMEKMNPVGSARSLRMPLRLATVFGAVGGFLYAYQCSSFRFWGWTENAAEIAKDKAEMAQRLKEGKALYGDSYMPEYIQDTSARTSRYSQLKFGAIPWFNFANHNNHGVDTSKYTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR00</accession>
    <name>A0A367IR00_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004107">
        <property type="protein sequence ID" value="RCH80085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR00"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017025062" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7280" checksum="8951971957C91E5A" modified="2018-11-07" version="1">MRPIYYILTFFIVLCAISVVNASNNLERKHITRSIPSDSSSSSKTTSKTEPIFALVVVIALGSLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR21</accession>
    <name>A0A367IR21_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-citrate synthase/succinyl-CoA ligase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004090">
        <property type="protein sequence ID" value="RCH80113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR21"/>
    <dbReference type="STRING" id="86630.A0A367IR21"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="10913" checksum="A10B284707B3179C" modified="2018-11-07" version="1" fragment="single">VFLEDKETEGIIMIGEIGGTAEEEAADFLKQYNLSRDVPKPVVSFIAGLTAPPGRRMGHAGAIISGGKGGAQDKIKALENAGVHVTPSPAKLGTTLLKAMQDAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT38</accession>
    <name>A0A367IT38_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003696">
        <property type="protein sequence ID" value="RCH80864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT38"/>
    <dbReference type="OrthoDB" id="2262048at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6743" checksum="E2CDB6013F6BD12A" modified="2018-11-07" version="1">MNSDKRTLCDYVPLKECLAKNNNDRSKCLKEWNEFQQACRQRKQATNDKSECEACKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT79</accession>
    <name>A0A367IT79_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003677">
        <property type="protein sequence ID" value="RCH80905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT79"/>
    <dbReference type="STRING" id="86630.A0A367IT79"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56171" checksum="EDBD6808E860CF6B" modified="2018-11-07" version="1">MIQDTGLGQEMFLSAYEVRNQDGSTRLECSKYNDEPISVDMSEDLLYSQHLSERTLVYCVSPPGETEWSREAHDVYKGSLEDQLSRLGIHDNKSSIKDKYPLPGKQHTSAIVKFYNDMSETLRIGQLVEIIGIRGQNIPEIETDESSFGLASVLSGFPNTAVIHAIAYNSLDQTTPLHEDLPDGSIETIRTELIDYIASVLGGDKLAAEFVLLQLLSRVTMKNRGLKIGHITININGLPSYRTIHENESPLFGVSNPVTKPLSDLLNSLNMHSVTLPLTIDGLNQSRFSPKSINENLQSGVLQLVDGTVLLVDETVLDEGQLKDTGVRNFQALQNVIQSQLLSYEFPYSQYNFDTDISLLSISTNNSILSNHCSVRIQPLYPLEDSEQSMLKLPKNKLNQFRKFIHSAKYGDYDIPASVSEYIQNAFVEERKKASETGDEMPMQEDLMLHMNLARLVTASFGEHELSKERFEYTVQLDKQRKSRMKKQVNKDTMYMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUA4</accession>
    <name>A0A367IUA4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_000974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003503">
        <property type="protein sequence ID" value="RCH81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUA4"/>
    <dbReference type="STRING" id="86630.A0A367IUA4"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000011">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="391" mass="42123" checksum="65FDD8D873250C01" modified="2018-11-07" version="1" fragment="single">MAYEPGDIAFILVSIALVWLMIPGIGYFYSGMAREKNALSLIMCCLISLVVVTVQWFIWGYSLTFSNNASPFIGNLDHAFLRNVLDSPSIGSDKIPELLFCVYQGMFAALTPALVFGSGAERGRLLPMVFFIFIWTTIVYDTVACWTWNPQGWIAKLGVLDFAGGSPIHITSGFSSLAYALILGRRQTDEFKPHNMSNVILGTTFIWFGWFGFNGGSALAGNLRSVMACLVTNLAASMGAITWMCLDYRVHHKFSALGFCSGAVAGLVAITPGAGFVSPGSALLIGCLGAVSCYAAVRLKNWLKYDDALDVFAVHGVGGVVGSILTGVFAESYVAALDGSTVIAGGWINQNWIQVPFQLIDVVAVSSWSFTITYAVLFLMNLVPGLSLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV68</accession>
    <name>A0A367IV68_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003384">
        <property type="protein sequence ID" value="RCH81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV68"/>
    <dbReference type="STRING" id="86630.A0A367IV68"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="351" mass="38814" checksum="A86442F8F4199E26" modified="2018-11-07" version="1">MSRLFGFGSNGSGQLGIGHLEDTHTPTPCIGIPESEVIIKISGGGNHSAVITKTGRVFFAGFSQLGEKRMSQILKLSSEEQQPWTIYQERFNKIKWKDVACGWAFTILISQEGKLYGVGTGRWNELCSDVRDEESLTEIPIHEKIISVACGWRHVVAVNEKGEAFGWGWGRYGQLGESKTVGNKKDIRPIQKIDLPEPVTQVACGHIFTIFRGYNGTVYGIGSNKYGQLGSEHDKGIITQPHVIYRDSIRIGAGWHHTLSQNSAGELTGYGRRDHGQITKTNVLQDIKQFFCGSEHTLAIQKDKLVGWGWNEHGNCTTDMDFMDEPIVIAESTNVYIFGVGCATSWFATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVI2</accession>
    <name>A0A367IVI2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-alpha-acetyltransferase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NAA10_1</name>
        <name evidence="3" type="ORF">CU097_006382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003353">
        <property type="protein sequence ID" value="RCH81629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVI2"/>
    <dbReference type="STRING" id="86630.A0A367IVI2"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="59" mass="6957" checksum="CE19510D33404F57" modified="2018-11-07" version="1" fragment="single">MNIRQATVEDLIYIQNCNLLDLPENYQMKYYLYHALSWPQLSFVAEDENGKIVGYVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW56</accession>
    <name>A0A367IW56_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003251">
        <property type="protein sequence ID" value="RCH81856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW56"/>
    <dbReference type="STRING" id="86630.A0A367IW56"/>
    <dbReference type="OrthoDB" id="5594955at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="286" mass="31281" checksum="CFC2D2BA623A74CC" modified="2018-11-07" version="1">MFTNGFFCLNQVDLYLLYSPSSGQYESIKNWTGLDKSTGVFVPTVDDSWYPQPIKDNSPNVSWTMYFYLVGTGADIQEDLAKIPSGHNQFPPPQPFTLIQSAHNTTHSTSAAPTSSTTQSSPSTLSTSSNDSNQGSNRLPGWAIALICIVSILFIAASIALIWAVRRYKNRKHLAAVTGTGSEHANDEKLLVPDHIALTSAAAPTATHDLSVHSASPPQQNRTLSSTNEKLPAMQQASLGIHSEANHSSSILSSTDALMIADTFRQFMRKPEWNEDLELNEKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY68</accession>
    <name>A0A367IY68_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002951">
        <property type="protein sequence ID" value="RCH82627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY68"/>
    <dbReference type="OrthoDB" id="2289352at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="14744" checksum="D54C2772B6F581AC" modified="2018-11-07" version="1" fragment="single">KLSSADFTIIADNYNKIAKKWILKTGRNVEDIIFKSTKDFIYEHPAHSFILDINDSVWKNHFSNEELLEMKANASLSDSNKDLPVNLQDMIWRLNGKTTFRDIYDVFNAIQVDPVNNAEEFWLSKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYD6</accession>
    <name>A0A367IYD6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002923">
        <property type="protein sequence ID" value="RCH82705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYD6"/>
    <dbReference type="STRING" id="86630.A0A367IYD6"/>
    <dbReference type="OrthoDB" id="2285485at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="233" mass="27271" checksum="31055253098D9FFE" modified="2018-11-07" version="1" fragment="single">NVKEWLNFLKTEAHEKRISYSVFRISQHYLCHIPYMIKAMGPLRAYSFRPMERAFGAISTLIKSKVEAGINASNVVERLALRRYVDFYSDIQQELDPIRPRPAPQYWEPFRCGVVATECNVSSDNWSIPTDTLYSCLQQFYRHTLNGEESRSPIDINIDIAARAWINSTVYSSVYYRNYRQEFRRSNHIVKFYGYNNKFNNFAVCIIFELVIVGFFVIEIAVYVGIIVVNVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYL3</accession>
    <name>A0A367IYL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002975">
        <property type="protein sequence ID" value="RCH82561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYL3"/>
    <dbReference type="STRING" id="86630.A0A367IYL3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19020" checksum="049459EBBC779B91" modified="2018-11-07" version="1" fragment="single">LKGRFEDTWAAMEKLLETGKVKNLGVANFSIPNLERLLKTAKVVPAVNQVELHPYLPQHKLLDYCNSKGIHVSAYSPLGSSQSTLLQDPVLNKIAQDRNKSVAQILLSWGVTRSSVLPKSVNPERIQSNIDLIELNDEEIQQINEISKTTTKRFIRPAWGVPVFDEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYN8</accession>
    <name>A0A367IYN8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_001541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002919">
        <property type="protein sequence ID" value="RCH82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYN8"/>
    <dbReference type="STRING" id="86630.A0A367IYN8"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="307" mass="34087" checksum="2CB0B24AC4FF7976" modified="2018-11-07" version="1">MTSSAPTSIPTEQYIKRTCEQCKRRRRPCNSQRPCTQCIEANQDCAYSVVHDHSRSVFSTHAARRLSSGSACETCRRRKTKCDGGSPCGFCASNNIECVNNSERRHLKNKQPSIEAMDRIEDRLRRIERLMTAFTPSPLTQPSSEGHKVRPHRHSVQGVNSAREKKEIQDRRGSPYSSRFGSLSPPPSSTPISIMRPSNSHSSSIAHSMLNLSISPSNSSTLLASSSSTPSSSGIWLESSPNGKNEYFRDHLPSPPVSSSENEWKISTIPSVMDQLSKRTFATTTNDYASTQFPIYPLTPPPSQQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZZ6</accession>
    <name>A0A367IZZ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002723">
        <property type="protein sequence ID" value="RCH83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZZ6"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="241" mass="27736" checksum="A9A36AB750A34A3C" modified="2018-11-07" version="1">MDDKEVMDLDLELEQELTNDDVQVPEEPIIESNVQLVADEPMDRFEALPRPTAIYLHGVNEMSTEDVKTYAGRPETLQKVEWIDDSSCNLVFDTAENAKKMAESILVEATDMDHKTLQKAKPFVSDDITCDQLSIRIATDEDIKRQGARERSRYYKIYGIQNEKLPKDKAEARRELIDRMSKNGGDGRSVFERLGNRVTEGRPRGRGRRERRSSRSASPIKRDIPDHLKQRLGSRRDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0Z8</accession>
    <name>A0A367J0Z8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_004529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002609">
        <property type="protein sequence ID" value="RCH83605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0Z8"/>
    <dbReference type="STRING" id="86630.A0A367J0Z8"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008035">
        <property type="entry name" value="PRK10767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="205"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="205"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH83605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="497" mass="54199" checksum="FF3F4BB62694D55A" modified="2018-11-07" version="1">MASRVSWRRASVFLTATLKRRYEFVNRPLTKQFISTVRNQSHYAIGGSFPTMYQKRCFHATAPSSAKRDPYEVLGVKKNATASEIKKAYYALAKKYHPDTNKDKDAREKFVQIQEAYEILSDDEKRKQYDQFGHGFDGGGMGGGPGAGFHGSGFPGGFDPNDIFSQFFGGGFGGATAGGDPFSRPSAGDDIQIPLTLSFMEAVKGATKYVQVNRVTDCQSCRGSGVRPGKSKETCKVCHGVGVQTIMMGGGFGMQTTCQACGGEGSSIPPGCGCPACNSMGKVRERKTVQVTIPPGVDQNSRIRVSGEGDAPLKGKGPNGDLFVTLNIQPSKIFRRQDSDVFVDAKIPFYKAMLGGRVRIPTIDGDVELKIPSGSQPGDNIALRGRGIQRFRGTTRGDQIVTLKVELPRSLRGRQKEIIEEYASLVDEEYRPKDNPIRNSNPSPDTPPPSPKMSPQDDNDDNKKNDGGFFKNAFGKIKDKICNDEDDKKKDDNGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1D2</accession>
    <name>A0A367J1D2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002572">
        <property type="protein sequence ID" value="RCH83736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1D2"/>
    <dbReference type="STRING" id="86630.A0A367J1D2"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="371" mass="43033" checksum="B2ADDE2CD9044D25" modified="2018-11-07" version="1">MNKRPSFVNFPIPFDHPYTIPTLLATVSASALLYYSLHASHKRDLKEAIRQQVIYKRRHLKRKEDKFASLKIEKQYVNPFKEWNANVPLWEYILYWLGIGRHDYSAKDLERLHVVRPNLDKLVEKNVSFIWLGLDGLVILTDPVMDHKKRVKPYPCQIEDLMGVVNIVLVSHNHFDHLDENVVKGLGNKVTWYIPLGLREWFVKRGVDNVIELDWWQEIHHKDRPDILIACVPAMHSSCSFWDRDESLWCSFVVKSKQHKIFFCGDTGYVPELFQSIRDLYAPFTIAALPIGTYEPPSIFKSLHMNPTEAIQAHHDLGSPCISIGIHWGTFHLSNENYLSPPELLARLWEAQNTNGSQFITTSVGQLIDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1L9</accession>
    <name>A0A367J1L9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RBM48</name>
        <name evidence="9" type="ORF">CU097_005787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBM48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002574">
        <property type="protein sequence ID" value="RCH83729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1L9"/>
    <dbReference type="STRING" id="86630.A0A367J1L9"/>
    <dbReference type="OrthoDB" id="78358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12442">
        <property type="entry name" value="RRM_RBM48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034264">
        <property type="entry name" value="RBM48_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH83729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="171" mass="20155" checksum="D38F181D926D2A54" modified="2018-11-07" version="1">MHKPDYREPKTAKTTCVYTISQESRYLIIENIPSLGVINELIKLCQQYGDIEEYKPLDHYPTSTAEIDVVWIKYMNIASARMAKRKLDEKPFFANMLRVNYAPEYESFEDIRSKFNDRITSISKRLNHTFNDRKRKRQSKESKDQAAVTITIDTNEDASHKESQAKTRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J309</accession>
    <name>A0A367J309_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_004952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01002425">
        <property type="protein sequence ID" value="RCH84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J309"/>
    <dbReference type="STRING" id="86630.A0A367J309"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="62"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="263" mass="30908" checksum="94BE5D24A66D5EEF" modified="2018-11-07" version="1">MSSEEPVLSDEQILEFEQQIKDEEAQKVPLVCQDEPISKLEEEFKDNQQFLNKIKNLAQEHDRIRRCRGDGNCFFRAVAFSWYEKAMNDISNYDTNLAKLKESCNLLESGGFQKLAYEDFYEVAFEQFERLGQYRTDPDMLLVNFQSNEISNAIIMHFRFVTSAYLRIHSAEYEPFIIDEMISIDEFCSRNVEAFGRESDHLQIIAISKALDIPIHIVYLDGGMENKATVHEFWPTEKDELERTKTPIKLLYRPGHYDILYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3P8</accession>
    <name>A0A367J3P8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002334">
        <property type="protein sequence ID" value="RCH84558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3P8"/>
    <dbReference type="STRING" id="86630.A0A367J3P8"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="374" mass="41762" checksum="44834DFB37EA3577" modified="2018-11-07" version="1">MVATIDITFLGTGSAQPSATRNHQAIALRLDGEIWLFDCGEATQHQFQKSKLKMGKISRIFITHMHGDHCFGLGPLLCSLSDNMNPNAVESAETKTPIEIYGPSPLRSWLRTTLKSTYSNLGRSYRVHELLHKDDPEDSNQDLHMNELPGHNIRSVEGVFEDLPYTNNYKVQAAAIEHSIPSLGYVVREPDQPGKLDSLVPTIKAQSDALRNKGIKNPMSILGVIQRTNEPYVLPNGHVLHPPPMRPGRSVVILGDTRDPSRIATLIDSPSLLVHEATNALTTLDEPGTTFEQVETRARGYGHSTPQMAGAFAKRMRCKKLILTHFSARYAGDESPASLEIMEQIRQLALKEFDQRMDDVYCARDLWSFEIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5J4</accession>
    <name>A0A367J5J4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002155">
        <property type="protein sequence ID" value="RCH85212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5J4"/>
    <dbReference type="STRING" id="86630.A0A367J5J4"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="133" mass="15357" checksum="703F542D3937B8BB" modified="2018-11-07" version="1">MKSSICRKCQGGGGYSINIMGEYKTLEVTKGKEYLKGYQALRDKEKGELGGNIRYFCSECGSHLYAYDKKYKEWFYPFASAIDTDLPELKPEECYHILLNSKANWVHTPSHNTFDEYPDCSLEAWHKSNGKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J625</accession>
    <name>A0A367J625_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002118">
        <property type="protein sequence ID" value="RCH85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J625"/>
    <dbReference type="STRING" id="86630.A0A367J625"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="321"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="446"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="900"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1068" mass="122551" checksum="6212FFED79FC93A3" modified="2018-11-07" version="1">MSRLPTSGITGKTKLSRQQSVADLRKRKTIEVSPVPIPSKSSNTKARSRSFVEPRPTKPISSPVQQDLYIGQRVAVDSMGIVGTLKFLGEAEFKEGYWAGIQLDILGSGKNDGSVKGVRYFSCPPQTGLFVLASKVTPLDQDSDSVRSLSPPSTKSRTVRQIGLTTTQLQHQQQKPINARPPSLHTPVTSPISSNRQSIRSLPQVQSPTPSHYRGIPSPAVTPTNQSSLQDDYYNDAIFSPPNEEMIADTPIPATVASTSESQEQLDHLFGESIRQAPNEAVMKLHQLQLRVEVLEAENRLLKPDGSQPKTDVDKSEDEHKAMVQGLLEEHEKKQKNWEQKQQELQQAIQRLETKIMELETEQMNLMTERDKTVFEATAVRKEKSILEHKVQELESKIVEAEAATAAAQASERMLLEKTKALQQQMNTTNHYFQPGVDQNDSAERQMKLEMEMEEAHEKMNSLREAARAKDMFLGQLSEQVEHYRNAVEEKEREIRRIKADADRHVREKDRVLEELKELETKWLAHQDCTSKESFDKLKKDYNALKENYQKETHLVQEYQERVRGLNETIDELKRAGLESIELYESSVEMNRVDREALNASLADERRKVALLEAERAELHNAGREAIQTYEATIAEIKKERESLIQEQNAKREALEATIQSLKQEIEQLMNNAATEDLKDVWEKERKRLTEQVVTSTEALEKEKSAHDQLRQEAEAWKEQLKESEKLAKERARLEEQLTRLQADYDEQLAARSKYLDEVRSAVESQKKAEAELRRMTEQKEKLERDLQEKTLAGATTADSEKYQLQVQALESEIENLSAQNTMLQKRMEENDQKNLAQLVESLKVENKRLVEKHSKLEESHKQVETECLKLMEEVEKLHHAEQQQPAVIKLEGLSDDDKVKELSQLLQENQNKIDQLVRNHASELRALKEKEEEKENEHKRQIASLNRDISELEGLIESKVFKEADLEEALDKERKMIKKLQMELQDLKEDLAMRSRYATVEEKKTTRLEFGKETELYCEICEIPGHDLLSCKAVTVEDDQPERPYCAICEEYGLHSTDKCQSQSEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J880</accession>
    <name>A0A367J880_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone dehydrogenase subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NAD5_2</name>
        <name evidence="8" type="ORF">CU097_002727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001935">
        <property type="protein sequence ID" value="RCH86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J880"/>
    <dbReference type="STRING" id="86630.A0A367J880"/>
    <dbReference type="OrthoDB" id="2360560at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000004">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="7">
        <location>
            <begin position="83"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="211" mass="23245" checksum="D29CEE91DE9B54B2" modified="2018-11-07" version="1">MNLSMVLFLIGILGFILNRKNIILMLISIEIMLLAVTLLIILSSFSFDDILGQTYGIYIIAIAGAESAIGLGILVAYYRLRGSDNYLVMFIGWEGVGISSYLLINFWFTRLQANKAAIKALVMNRVGDWGFSIGLWAIFWTFGNLDFTTVFSLAPFINEELITIISICLLVAAMGKSAQIGLHTWLPDAMEGPTPVSALIHAATMNLDQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8L8</accession>
    <name>A0A367J8L8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001898">
        <property type="protein sequence ID" value="RCH86302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8L8"/>
    <dbReference type="STRING" id="86630.A0A367J8L8"/>
    <dbReference type="OrthoDB" id="1432093at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="535" mass="61798" checksum="1450778F785C1912" modified="2018-11-07" version="1">MEILKSDFEQKLPFIKKAILEADFIAIDCEFTGLTPPHININNADDLAQRYSKIRSSVEEFTIVQYGVCTFKRDKETGDFIARPFNFYIFGNDPDNMQSRRVFSVDASSLAFLHSNNFDFNKWIKEGIPFYNFTEEGTFYESAYGTLRMNNRRTRIEESALTQSGKSFLEYNRKAINNWLQGNTEQPLIIQVNTPFYKKLIFQEVQENYNNFLQVMSRDLKHVEIVRLKEEQRKAKLQKTSALNFRTIIETIGDAKCPVVAHNAAFDILHTTDQFWQYLPDNLTKCKEVVNSMWDYIVDTKYLAEYHPLLKGCFSTSVLGSLFNTVHSELEEAGQKIVLAPGFDRYIKSNKPNEHEAAYDAYMTGVIYLAFMMYINEQADKQNNKENDEQINKSNGEQINKPNGVENGVENGEENEEQNGEVNGEQKEGDNNKEKGITLLGKRKRDIIESDDAEDTIETNEEGETTENSEDEEEKEEGEIESTKVIDEPSRALFFNKSVIPYYGRIFLMRSDTPYINLKGEEEVSVESRKKLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9E2</accession>
    <name>A0A367J9E2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uridine kinase</fullName>
            <ecNumber evidence="8">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_007551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01001848">
        <property type="protein sequence ID" value="RCH86530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9E2"/>
    <dbReference type="STRING" id="86630.A0A367J9E2"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="268"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH86530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="476" mass="53504" checksum="DC87443C8CCEE352" modified="2018-11-07" version="1">MFTRKKTLVPVSSSKLDGSHSLFINQLFSPDGSIADPYLIGIAGGSASGKTSVAERVLKNLNVPWVVIVSMDSFYNILTPEQSKLAHQSLFNFDHPSAFDYDLLYDTLKKLKEGKSVTVPIYNFSTHSREEKTVTIYGANVIIFEGILALYDKRIRDMMDVKIFVDTDADIQLARRLQRDTTYRGRDVEGILDQYTRYVKPSYDSYVRPTMKFADVIIPRGLENVIAIDLMTKHIQTQLNENVINFRWNLLDTPVKEEVPNNVHVLPTTNQIKGIHTILRDHNTERDEFVFYADRLAVLLMEYAINLLPSEPLTVTTPIGAKYEGLRYSQKICGVSILRAGGTMEAGLKRVFSDAVIGKLLIQTNPNTGDPELHYCKLPNSARDHNVVLMDAMVGTGAAALMAIRVLLDHEVPEDRIIFVSFLAAQIGLTVINNAFPRVKIVTSMVDPDLNKEKLWIVPGIGNFGDRYFGTEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9K2</accession>
    <name>A0A367J9K2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_008396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01001831">
        <property type="protein sequence ID" value="RCH86607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9K2"/>
    <dbReference type="STRING" id="86630.A0A367J9K2"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="104"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH86607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="347" mass="40145" checksum="A22D4BBF31DF81D1" modified="2018-11-07" version="1">MSSFAIPDTKSLKRKRELEIELSKEVEDQPTSRDASDEDNTDTSLPQPLHQELSPVTKKLRQFGPNLSTSEEENDHLVCLPPGIEEQYGFRINPPPVDRPIRIYCDGIYDLFHFGHAKALEQAKKAFPNVYLLVGVCNDIETHKRKGKTVMTDVERYEAVRHCKWVDEVIENAPWIIDQEFLDHHKIDYVAHDAEPYQSKESGDVYAFVKAQGRFFPTQRTDGISTSDLITRIVRDYDAYLRRNLERGVSAKELNISFLKERKIKTKKSIEDFRQTLKTAINDTILHWEDKSHDFIRGFSGVFGAEDVVDKFWKYRNKKRLQSENSSSQASSRVQSEDEEMEKGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9M2</accession>
    <name>A0A367J9M2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001822">
        <property type="protein sequence ID" value="RCH86652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9M2"/>
    <dbReference type="STRING" id="86630.A0A367J9M2"/>
    <dbReference type="OrthoDB" id="2384641at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="216" mass="24891" checksum="4BB6DF774B6327DB" modified="2018-11-07" version="1">MTEQKSEGIYTYCIEYAKTTQSRCAACKKGISVKSLRAAEIFRKSPKEKKNLARHTWYHFKCFKVPTLLTQIPIEQFRGYPTLKEKDKARVQKLIKHGKGATWAAIVEKEKAEEGEEEAVTKKKETIDENIDITEKLTGIQEKTEKNKTEEKKTEKKKVEKNGKKLKAKTEEKNKVNKKKKPATTEVAHKPKKVVLPTEDQIELETIAKEFQALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9V8</accession>
    <name>A0A367J9V8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tubulin beta-6 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TUBB6</name>
        <name evidence="5" type="ORF">CU097_006976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001808">
        <property type="protein sequence ID" value="RCH86718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9V8"/>
    <dbReference type="STRING" id="86630.A0A367J9V8"/>
    <dbReference type="OrthoDB" id="6073114at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="15749" checksum="0E5DCE10AD84A1A9" modified="2018-11-07" version="1">MALNLESESPSMKAIILVDLEPATLSNVRSSAYSRLLRSSSFINAQPGADGSLEKECYTEDTELVEQILNVVRGTRSGLGSLLLPKTCEEYPDRVISIYSVLPSRKLLFLHQLAENNDATFCIDNEDLDIICFWALKLISHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA18</accession>
    <name>A0A367JA18_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_003027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="PJQL01001798">
        <property type="protein sequence ID" value="RCH86766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA18"/>
    <dbReference type="STRING" id="86630.A0A367JA18"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="178"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH86766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="311" mass="33532" checksum="55FD57F3DAB04623" modified="2018-11-07" version="1">MFEACQQQNHRKNAIGLIGLGQMGSGMAKNLALKATGPVYVYDLNDKAIQSLTKEYAHLKVAKDPADMAKQVSTVITMLPESSHVENVYEAMMDYINEENILIDSSTIDSQAAKTLAEKVMREKQALVFDAPVSGGTLGAEAGTLTFMVGAPSIESFTKVKPTLEWMGKNVVYCGSNGTGQIAKACNNMLLGISMMGVSEAMLLGTKKGMDPHLLASIINTSTGRCWSSDTYNPYPGVIPTAPASRDYQGGFSNKLMAKDLKLAMKAAKDCDVSPPLGTMASQMYEKLAKDNEFGTLDFSSIFKFLSTQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBQ4</accession>
    <name>A0A367JBQ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Insulinase (Peptidase M16)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IDE1_5</name>
        <name evidence="2" type="ORF">CU097_010809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001674">
        <property type="protein sequence ID" value="RCH87364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBQ4"/>
    <dbReference type="STRING" id="86630.A0A367JBQ4"/>
    <dbReference type="OrthoDB" id="5099124at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="24075" checksum="0487D0D7AD9A2061" modified="2018-11-07" version="1">MSEADYQAQVDSLIAEKQEKFKNLFEEGYRYWSNIMSGYYEFNESTTDVLELKKITKDSLLSFYNNYIYPTSPMARTMSIHLKSQKAPVEEKPSLTAENVYSVLTALNYLDKKDISEDTFRDWVISYAGDAAQFKTELEFSQFLESKKIETGQIKTILEKIYQGPSGLSQRDHSRLPDKYEVIADLIDFRRRMPLSPAAVSVLNSVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCN2</accession>
    <name>A0A367JCN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="6">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="6">EF-G2mt</shortName>
            <shortName evidence="6">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">MEF2</name>
        <name evidence="8" type="ORF">CU097_003196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001611">
        <property type="protein sequence ID" value="RCH87666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCN2"/>
    <dbReference type="STRING" id="86630.A0A367JCN2"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="44"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="795" mass="87177" checksum="BC8CA0AA710B2BD5" modified="2018-11-07" version="1">MYPNVLTSLLRSTCHKRVSSLLRYPKSITHFKTFATDAKDFTIPKTRNIGIIAHIDAGKTTTTERMLYYAGVTKRIGDIDDGDTVMDYLAAERERGITINSAAITFGWRGHRINLIDTPGHVDFTMEVERSVRVLDGAVTILDGVAGVEAQTETVWKQADKYKIPRIAFVNKLDRTGAAFGRTVREIWKKLLTRPLVLQLPVMHGEDKGLKAVADLVTMEVIEWDPTHGDGSVMHRKPIEDPILLEEAVRGRTALIEALAEMDEKIIDAFFDDAGGDHLAVTPEAIKASIRRVTLDNKAVPVLCGAAFKNLGVQPLLDAVLDYLPSPLDRPPAIVTDSRGKTTSVPLSESGKLYALAFKVTHDPKRGPMVYVKVYSGKLNARATLFNTTTRTKERVNKLLQMYAKDVEEIPTIGSGNIGVIVGLKDTRTGDTLVQSNDSTAIKSGHQLGSIEVPHPAFFAAIEPASVSEEAAVEEALKNLVREDPSLRVWTDEESGQRLVSGMGELHLEIVRDRLLNDFKVKAEMGKMRISYRETCQGEAAVVSEYDKEVMGKRAKAACRVEISPKDDEEPGEGWFSYAGNLLAADVSLKQDPATEQQQGDSSLDPEDVKQAVQNGLYAGMARGALLGFPLTKLKVKAYDLRTFGPETTLGAISACVSNGVYDAVKKANPCLLEPMMEVYTEVNENHIGTVVSDLSGTRRGHVMGLESSDVLDTENTDHVEVYAPNDSLLINTQVDEYKPKQVIKAHVPLSSMLGYSSALRSLTGGSGSFSMRVIGYGEMSKDRERAVINEMKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD17</accession>
    <name>A0A367JD17_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001577">
        <property type="protein sequence ID" value="RCH87862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD17"/>
    <dbReference type="STRING" id="86630.A0A367JD17"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="371"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="849" mass="97071" checksum="E29CC62B015176DB" modified="2018-11-07" version="1">MNLLEGQTAPESTRGLFDFPEPTKRREKQQQRRRSVELTPRPASTYRASLQPVNEETIMMSRADVLAETEAKLTRRLSEPVTKRATPTSRPASARLSTGSMSSLFDRKPLFTSHLPFSSVLPHIKSHVLVSGLLRVNRRNRSNAYVFSEELNSDIYICGSRDRNRALEGDYVAVKLVEVERVLMEKHEKEEAKLARNHGQPLIRKPDEEDEKEIIFGGEDDVEQIPPKYCGTVVAILDRAQNQVFSGTLGLTRPSHKKSDGPQQERRNSMNSPPRIIWFKPTDKRVPLIAIPVEQAPPGFVENPNLFEHRLFLSSIRRWPITSLHPFGVLERELGSVKDVEVQLDAIFADNNASTDVLSLDASLTDAFKDRLDLRHVPCFTIGKDKQNALSIEQMEEMVKVGFHVADVTSLVELDSQLEKEARSRGIQMDGVLKQIPIWPDELRERVELTENKDRGAFSVIWTFTEDGKIADTWFGRTLIHSSTMLTDKNVRDILDLDSIDEEGVETDILTLYSVACMLHSNRRHGLKRPQLVFHFEQDSTKPSQVEVSDHWQVLFEEFQILANKYVAQKIASHLPDQALLVSQPPHHTRKLKELVNYLKEFGYTLDPHAFEQSIDRMTPPEAQQVVRALLLKTFSTEKYFCTGAYDISRFYHHGLDVPLYTHFASPLTRYTDALVHYQLQSALSDTTFHLDTEAVQRIAQQCNAKAKAARQILESAQHLFLSCYLDSVQQYDAVVVGIQEGAFDVIVLPLLLERRIHTIHLPLKSDTFDPNENKLHLIWQTSQQQQQQQTSPTNQKRRSICQKQEEDVLFPEEARQVIAPFDVIRVIVESYPVRNPPLIRVLARNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFB9</accession>
    <name>A0A367JFB9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001468">
        <property type="protein sequence ID" value="RCH88431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFB9"/>
    <dbReference type="STRING" id="86630.A0A367JFB9"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047315">
        <property type="term" value="F:kynurenine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000071">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000166">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="429" mass="48097" checksum="40BB4F11CB26B20A" modified="2018-11-07" version="1">MDYSKHISKASQARNPSAIRALMPYLNCKDMISLGAGQPNPATFPFASLTLTLKTGEKIEVDDQLFDRSLSYDLTSGQPLLNQWLTELQKIEHNPPVEFDVSIGSGSQDLLTKALEMMISPGDSVLVEEPTYTGALSFLETMPCDLAPVATDEFGIVPESLDHLLAHWPESNPSGKKDQPRPHVLYTIPSGGNPTGVSATLERKQAVYKICSKYDVIILEDDAYYYLQFDEKRTPSYLSMDVDGRVLRCDSMSKILSSGLRIGWITGPQPLIERINMHTMVTNLQPSGVSQVVAYQLLAKWGHKGFFDHVKSVANFYREKRDEFLECLNKHMKGRAEWNVPNAGMFFWLRLLGGITDSYDLVMTKAIKENVLAIPGLAFMPRGNKNEYIRVSFSNVSKQQMDEALRRLARVIDREAELHGLRTNNSSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG25</accession>
    <name>A0A367JG25_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01001388">
        <property type="protein sequence ID" value="RCH88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG25"/>
    <dbReference type="STRING" id="86630.A0A367JG25"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="9">
        <location>
            <begin position="137"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="811" mass="92394" checksum="1D66F3FA5B584FFC" modified="2018-11-07" version="1">MANDSIIMSRSKVAIATIITASVLGTFYYRSKHKKKTKEPDIYREIIESLPDTDPIKQQEDETNNFLGNLFKNASDIVPASLEEFKSKMSSLYPAFERQLENIRNMYSSFWNYLFLEDFRKIVKESMKEDTDTSLHPEIEQDAKVREGQDLSKDEIEYVKKRKERMKAAFAFFIGVEESEVEVEDIPNIGIASSGGGYRAMVACSGYLHGFCDTGILDCALYMAGVSGSTWAMSQFYSPLTDASVNTLKHHLSSRIHTHIANLSNFLAVLNASRHNAKILLHGVIQRYYQQNHSISLVDIFGMLLGGTLLARKVVVDTDEEKDKDEEEEYSESISIKESTRNVETGTMQENDGTKVEPRLLQKNEIKLSRQRTYFDDGSLPMPIYCAVRHEIQHPGITKQATLSSQDEDNEVKNGNDDKNDKDDDEANEYSKDKDDKHDNKVNEVNEYNEIKHDKGDKNDRNNKVSNNGSSQDLYQWYEFTPFEVGSEEINAWIPVWAFGRKFENGMNIERLPEQSIGVLMGMFGSAFVASLAHFYQEIRVLLPAAAVEKADEIIKNYESSACTIHPISPASFPNPFYKMASTVQTKDENENKEEVLRSENLVGSQQIELMDAGMDNNIPFYPLLRKGRDVDIIIAVDLSADIQDAPHFDRAEGYVKRRGIKGWPEGAGWPKEKDKDNQHDPVEIKKKEKGNNRTLVEISSEYSLDTCTVFASSSTETTPEDKDSIKTTYPENTNPITLVYFPLIVNRNYDPDFDPQTAEFCSTWNFVYTTEQVNKLHGLAVANVKDNIEKVRKVVKDIWKRKREERLNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH08</accession>
    <name>A0A367JH08_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001323">
        <property type="protein sequence ID" value="RCH89242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH08"/>
    <dbReference type="STRING" id="86630.A0A367JH08"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="119" mass="14025" checksum="259B58E57B831D55" modified="2018-11-07" version="1" fragment="single">MTSLDTLTEQQKEVLNQYQTITETKNLDEALGQLIEHDWNLERAIESKYETNNIQQEHREQLEQECLFIYSLISARIISQQQSITGGRRPPRDTRVLAYEFIQAFELNYGQTHVDFFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKY4</accession>
    <name>A0A367JKY4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001134">
        <property type="protein sequence ID" value="RCH90361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKY4"/>
    <dbReference type="STRING" id="86630.A0A367JKY4"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF9">
        <property type="entry name" value="PROTEIN SPINDLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="55169" checksum="E27776A694FBBE01" modified="2018-11-07" version="1">MLASETRPKLTLPQQKLSHSTPAPHYYEEPCSPVSTTTSFISNVSWIAEKSAAELGVLLKSAYKSLREKEKDLVLVAEIGKSLLEYNQNLKSDYDKLLQNASSMNQEQQEMRLISSKKTYDKIIESLEHKNEEIQYMLEQTRQRSKITQQNHEKNQRKLEAEIEILHHSLEIASQKIQELEEDRLLNQERASRQHQQKIEQQRKEDLILLEELTTKMEELHRENNYLQKSKRAVEEKLATALKDLEQLQQEFEHFELTQNGYMSLQEAFQRQTDHVKELNDRLEEHRNILARYRDKEQWLTETPISHATSTSNLMHELDTAKCLPKSNSENDLPSYASKICDLATLTERHLTSFYNAPADYAFDTILSTIGIDDRASLHEAEKLLCSINTDEASLFGPEGSGTVYAELDIYPTLKVPQQVQKEEQEQPKGLIHRILFHIRYLFRSVFRWCRFALILATAVFINLWKGPDLILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM18</accession>
    <name>A0A367JM18_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001049">
        <property type="protein sequence ID" value="RCH90909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM18"/>
    <dbReference type="STRING" id="86630.A0A367JM18"/>
    <dbReference type="OrthoDB" id="2249524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="934"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1037" mass="119808" checksum="6B3A31F75EE328DF" modified="2018-11-07" version="1">MYKAPSKERNLGIRTNGDWRHRPISPSNSTSTPVRSASPNIPSPLPRPGRQNTTSKSVAALQQQWQQQQEPPMKPSRYPLTRRISSEIKYTPESTNDVEVIYDDDEGDDVEEERMVVIQDVRSRSPSIHRGSTGSVQSYFGQEFRVVKEGWMYRKNGLMQWKPVYAVAKHGNSVKPGGLYLYKDSKCTHHIQTYDMSEVLEVSPRAQEYKPGIKWEIRMLVKRDDITLATDDMTSRKDWIDSLTSIMGKVSLATQNELTSRIQTSEQMNRDLQQVAEELDTENHQLRAQIESLKEAAVKKEHQFQQEIELREAELKEALEKQERLFKKDYQAREQELAAELDRTRQALETKCEIYEREAKQWRAKYVELETRQSRNLDTDEKKVEMLEMEVLKWRHRVSELEEKQEQRKTSEKPTETNVTETLSDVKFNLQLLRDHLSHPSNEATPALDEIKTSIHKLAETLEEAKSNWKQLEDDIVKLLETEKQNAEGKEASQKHSLSLLADDINHLREELVGITLDSDEENDNKKTPSLTEKFDILIDMVENLQIGQSRLSSTLSEKPNTEKKPTEGYQEKLDAWMQETRNMIESHHPPGSEVQSLYDKLSAKIESVLMELIKSQEQNQEEQTKHIKTIGNYLQLMTNDIQNSAIPDLPALSQQLEDVVERLAVTESRLCQVNPGTLMAPSNWTPSPPAEELKNMSDDDRLTQLHNFVKNTERFMERALLALSRYEGGNSNSIEEIIRRAVKGASKLQIEQVMALQDQNVEERKEIDKKMQRYEENARVYFDKSMEKMHSDLHEFTGVMYEMLERLVLQALEHDPSLTNNANPDGQQQQQQQRSVQSVIDIHAKLSGLNQALKAEIERLEIEKQGLEANVRKMRQDSKELERELDKKQAELKFIKSEYDRMNQDIQRSRHDAANQLARELEPLMHQIAKLKRAAGDNTMAPESDDSGYTHMADESSSLSRHPLPVTPNRLSRYEDEGTERKLRFPNHRKSSFSSQSSENTENKQYYDQQSIKSPLIGARDRPRGKSPLAGFLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM80</accession>
    <name>A0A367JM80_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DED1_3</name>
        <name evidence="16" type="ORF">CU097_009389</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001029">
        <property type="protein sequence ID" value="RCH91043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM80"/>
    <dbReference type="STRING" id="86630.A0A367JM80"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="317"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="521"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH91043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="705" mass="80141" checksum="3AABC31435BF9424" modified="2018-11-07" version="1">MSNWDSSQLEKQFDNLTVDGDANKWSNVASQRTQNNWQRGPYQQGHSTRGRDGQYSSNDNRGRSRGRGGYEQSYRGRDQRGGYQHQQAPQWKQEQSRSQRNDWQQQNTWGQQRGSITWGNSSSQSWNTQSNTSQNWNTQSGSNQDWNSNKTSVYPVNTAATSSSNSWSQKLTENTASWNNTEPKQATEEKTSWEEKSTSFSGGWGEMTLESMGWTESNKRPKNVKQPGKGIWKDGVHELGDKDEEVERKLFGTADDSQVQHTGINFEKYDDIPVETTGSNVPEGIAEFTHPPLDKLLIDNIRLAHYTVPTPVQKHSIPIVAAGRDLMASAQTGSGKTAGFLFPILSSMFIHGPLPEPDDSEVKQGYRSYRKAYPQALILAPTRELASQIYTEAKKFCYRSYVRPCVAYGGADIQQQLRLIDRGCHLLVATPGRLVDILERRRLSFQNIQYLVLDEADRMLDMGFEPQIRRIVEGEDMPPPGKRQTLLFSATFPENIQVMARDFLKNNIFLKVGVVGATTENITQTVVLLTDEEKRSRLLQVLKEHNRKKTELTLVFTETKRMADTVYEFLLDNQYAATVIHGDRVQSEREAALESFRTGRTPIMVATAVAARGLDIPNVMHVISFDLPNNIDDYVHRIGRTGRVGNTGYATSFFTRQNRFLAGHLIKLLEGANQEVPSWLEDMRVDESDMYSNRPQENTNTRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMD3</accession>
    <name>A0A367JMD3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001027">
        <property type="protein sequence ID" value="RCH91055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMD3"/>
    <dbReference type="OrthoDB" id="2243575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="360" mass="41841" checksum="EC395EA627A399E7" modified="2018-11-07" version="1">MPPEDMDEEDYKNLLEQLQIKPKPVIFNDIANQYYDKIKGAVRLSTISSPWLSLNVHSGFLQHPLTMVMKDRSFIFKKYQKQCKFMNYKKIAVTTILSIYRWRVFKKLPYIGSGELAYRSVFAHPYIEAIISCINNPDLGYSTGEKSVKAMNTQMDRLKLRVSHYESYKADGIIYFKEIEIFLMENSGSYGNCTKHKASGDHHKAVYGVLGMLKTIADTYRYATFDTFQRLKVFFLQTREKIMELWSIKAEQKNSYILYREAMMFVSVDVNDKNNMLEDSFTFLNTMKDMLMETTDILSQIIEEHESFTQSISANETQAPTHSLKELIDPPIFKIIVEQGSRGLGTLDYEEYSVKLSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMI2</accession>
    <name>A0A367JMI2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001010">
        <property type="protein sequence ID" value="RCH91170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMI2"/>
    <dbReference type="STRING" id="86630.A0A367JMI2"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="23838" checksum="A1ADE5328D54A8A5" modified="2018-11-07" version="1">MSLSITPRQCDKPMSISSITLPSSYSDFSVTPPISPSKKIQLHQPLSPHFSCSVPSSPESVTDHSILPPTLLIKLEHQSNQASNNGSNNGSNNVSLSLHERRQRNKAASAKYRAKKNQQHGEMRSRIMSLSQENDILQRQLEYARQENHKLREACDKLRGKMLAENVLQKLLHNNNNSIHGDDLCDVINDTEEEEDEYLIVQQSQSLNHCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNC4</accession>
    <name>A0A367JNC4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000978">
        <property type="protein sequence ID" value="RCH91369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNC4"/>
    <dbReference type="OrthoDB" id="2235992at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="565" mass="65611" checksum="BCF692641EE61178" modified="2018-11-07" version="1">MNNDNATKLPSEIIKSIALYLNKVDRLSCLTICKAWYKTLINLIYEDVTFKTLKSFRIFLHTITHHSNVLRPGRAVRTIQMNIDSMDECNFGEKEMVFTEFELLARHCPFVTQLTFRFPHYWRFLHELDLDHHWLYLSKLSDCDGSRKSRKTMVSLGHRLTTYGVDTSLSLSSYGITREHILQDISMLPSLKVIRLKSKYFHLYIQDIVHIFREHPQLEELSLWVKMKKAPDTDDIPTYSNKEQRIHTLGCLIDNTQHPWIPFIKRNYSYIDTLAFQVAYQKNQEGIVQPMSDRTKADILDGILGLFHNEYMTSSQDTHKLSVRRLHINLGKAGGLLLAIYLSSIIYMTSAAYVHFTISTSLHINFIHDFFEHMPMANSETEFLPLQSQVHHSFNIVHPFDPMDNNQGLIEHLKLATESLTYYITELTIKETRKYMATYSLGFQCLDTILEHFTYLKTLTFILSNTYLFDDSDSSGNSLEEIDEVTYVGEVTLSHPDASTHIKHDTLTSLTVKEGKMNTKVFSYLFNKCPHLSSLSIRKYGYDEESLLILECLCLENNVNLIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNJ5</accession>
    <name>A0A367JNJ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000968">
        <property type="protein sequence ID" value="RCH91455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNJ5"/>
    <dbReference type="STRING" id="86630.A0A367JNJ5"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="14084" checksum="29398FE65568219C" modified="2018-11-07" version="1">MSDIKTPGFQSSEVFATLKSSLESLPADKKAQLLKQVKGIFEFVIENNDKKKETFTIDLKKDGTVVKGQGATKADAIITIKDGDFVDLASGKLNGQKAFTSGKLKIKGQMMLATKLDTVFKQLAGNKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP16</accession>
    <name>A0A367JP16_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PGA5_2</name>
        <name evidence="13" type="ORF">CU097_010779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000931">
        <property type="protein sequence ID" value="RCH91710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP16"/>
    <dbReference type="STRING" id="86630.A0A367JP16"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016984351" description="rhizopuspepsin" evidence="11">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="79"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH91710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="401" mass="44008" checksum="E9FA41B702B22217" modified="2018-11-07" version="1">MRNSHLIAWLITSQIILTVAAQSTLNVELEHTDGRAMSTLARIKHALGKYGIVDNELNGRISSAISGIELESVYVDIEYIGEISIGTPPQRFTMDFDTGSSDIWIPSISCLQSCGTHRRFDPTKSSSFEIVNNKTWRLQYGDGSSVRGYVGMDSVHIGKVTQDRQLLGLVSAETVDLSRDKYMDGIFGLGFPPLAYTGLQSSIVEDLFHSGRIAGPVVSFYLGHPRDGGKGEILFGDINKEHFEGELKYVPLTEKTYWQVDLNGIGVKGKDIMNGTSMPAIVDTGTTLIILPTALSKAIHASIPGAQYNFFYGWRMPCDLADSKSDEAITFNLGGQEFPIPLRDIVRAKRSVDINPFNNLCFSGIGEADTPLAILGDTFLRSYYSVYDFGNARVGLAKSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPZ8</accession>
    <name>A0A367JPZ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HEM15_1</name>
        <name evidence="13" type="ORF">CU097_007168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000887">
        <property type="protein sequence ID" value="RCH92023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPZ8"/>
    <dbReference type="STRING" id="86630.A0A367JPZ8"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH92023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="396" mass="44770" checksum="C94DE7ECEF5D3190" modified="2018-11-07" version="1">MNIGSLLTLQVKQQQHLRNATRAISWAGIQRLYTTQANTKPPTAVILTNMGGPKTVDDVQGFLLNLFSDRDIMQFPFQSAAAKFISTRRTPKIKEQYQAIGGGSPILYWTRKQGEAMEKLLDTISPETAPHKHYIAFRYVEPFTKDALEEMKKDKVQRAIVFSQYPQYSCSTTGSSLNELHRRIKELGMDTDIKWSIIDRWPTHPGFIDATVHKIEQKLAEYGPEERKDAIIMFSAHSLPMSVVNKGDPYPAEVAATVDRVMSKLGNKYPYRLCWQSQVGPKAWLGPQTSDALKGFAKAGRKNIVVVPIAFTSDHIETLFELDQEYASEAKELGITGWKRVDALNDEPLFVKAMANIVKEHIDKGEVVSKQWPLRCPGCDFDTCGHSRDFFTKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ17</accession>
    <name>A0A367JQ17_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DBP3_2</name>
        <name evidence="18" type="ORF">CU097_004139</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000884">
        <property type="protein sequence ID" value="RCH92044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ17"/>
    <dbReference type="STRING" id="86630.A0A367JQ17"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="140"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="345"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH92044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="523" mass="58765" checksum="4322A0D01FF56BC6" modified="2018-11-07" version="1">MSPSIIEKAEKRKREQDEVLNDKKKSKKDKKEKKEKKEKKEKKEKKVKQEETKDEPAVKKINETEKNVEILASYKYKQNEELSALPQSTIDEYLKKHTIDIQGDLNLRPIMEFKYANLPDNMMQVVKNFAHPTPIQAATWPITLSGRDIVGIAETGSGKTLAFTIPGLVHIASKLKRGKKTGKPSMLVVSPTRELAMQSAEQAEAAGKAVGVTCICVYGGVDKYPQRQAFQRGVDIVVATPGRLIDLMNEGVCDLSEVSFMVLDEADRMLDDGFENDIRSIMSHSPKTRQTLMFSATWPESIRKLASDFLNNPMRVTIGSTDLAASQNVQQIVQVIQNPRDKERHLLDLLKKIHKSRKNRVLIFALYKKEAMRVEKSLEYHGYKVIGIHGDKNQAQRTQALNSFKDGSYPLMIATDVAARGLDIPDVEYVVNLTFPLTIEAYIHRIGRTGRGGKKGTAYTFFTPEDKAHSGELINVLKQANMNVPEELLKFGTTVKKKTHSAYGAFFKETTGAPAKPTKIIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR94</accession>
    <name>A0A367JR94_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH kinase pos5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000823">
        <property type="protein sequence ID" value="RCH92470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR94"/>
    <dbReference type="STRING" id="86630.A0A367JR94"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46829" checksum="9447DF31BF6C8E44" modified="2018-11-07" version="1">MTEEYDPSKDTILIISKARDRKVVEFTIELAEWLIFTPRFGKEHPFTVYVDAHLDTPKLFQRLTHPAWQTYLKFWTPKLCYRQPDLFHLIITLGGDGTILFTSTLFQSHVPPIMPFHLGSLGFLAPFLFTSYRKELDNLFEKRLSKTRRMRLSCTVYRCKSSPDTRENKELVETEWIQNALGQEISKNTTASGLKSYSAVPGQTFHVLNEIVIDRGSSSNMSLLELFANDRHLTTVQADGLCIATATGSTAYSLSANGSLTHPDMHCTLVTPLCPHTLSFRPMILPSTMIIRVVVPFCSRHTAHCRLDGRNTIELKQGDHVKITMSPYPVYTYASTDVSNDWFSSVQTCLQWNVRKRQTSAILSNDSLLSKDAYSSNRLTENEQDGIAPWTEQELERDSFISETENVRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JST1</accession>
    <name>A0A367JST1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SSO2_2</name>
        <name evidence="5" type="ORF">CU097_013709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000758">
        <property type="protein sequence ID" value="RCH92966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JST1"/>
    <dbReference type="STRING" id="86630.A0A367JST1"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10627" checksum="D3A0EE285ABB38F0" modified="2018-11-07" version="1" fragment="single">YRRQQAQNTLDAVQERHEDIRRLAKSVQELSVLFEEMQSMLESQAKVLDQIETSAIETNNQLEAGTQYIEKAKKSALSTRRNKFICLGIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTI4</accession>
    <name>A0A367JTI4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000721">
        <property type="protein sequence ID" value="RCH93247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTI4"/>
    <dbReference type="STRING" id="86630.A0A367JTI4"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="331" mass="37553" checksum="61A5D1DDB0191239" modified="2018-11-07" version="1">MTVPKMIDNLSIIDTLGKGAYGQVYLGQHEQELYAIKSLHHRTKQQLAQQALEIELHARLSGHPHIIQLKRIIRNPHTDWTHVVMEYGPEGDLFTAITEKDLYIGNHSLIRKVFLQLIDAVSYCHQNGVYHRDLKPENILVFDGGHTVKLADFGLATTSTISHDYGCGSTFYYSPECQGDLLRGANRIGYATAPNDVWALGVILINLTTGRNPWKQASLTDDTFYAYLNNPDFLLHILPISKELNRIIKRIFCIDPTRRITLPELKDRIRHCKYFTRTAESNRSEHFAHLSKHIQLPPSPPSTPHTTNPACQQKTNCEKVNLSTVLTTLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTP9</accession>
    <name>A0A367JTP9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FMN1_2</name>
        <name evidence="13" type="ORF">CU097_010022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000709">
        <property type="protein sequence ID" value="RCH93352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTP9"/>
    <dbReference type="STRING" id="86630.A0A367JTP9"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.30:FF:000005">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain-containing protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH93352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="19415" checksum="06C7565C8315C052" modified="2018-11-07" version="1">MNSVNINPDRPLLVGPETPKEPFPFALTGTVVKGYGRGSRELGIPTANLSEEAIDALISGLETGIYYGWAQIGQVGTQVYPMVMSLGWNPYYQNEKRSAEVHIIHEFPEDFYDESIRVLVLGYIRPEQDYPSLGALITDIKTDIEVAKHSLKRKVYAEAKEHPLFYKIKSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTW4</accession>
    <name>A0A367JTW4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000736">
        <property type="protein sequence ID" value="RCH93131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTW4"/>
    <dbReference type="STRING" id="86630.A0A367JTW4"/>
    <dbReference type="OrthoDB" id="2235701at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="441" mass="47886" checksum="D70DE9736971A8FE" modified="2018-11-07" version="1">MKSYQKDTESSQQRKKDADRAKESRPQKKTMKLKPSKATKLSVSREKFTRERLLKLKEQAQPLRSKKQESNAKQITQVVVPTKPSSSKAPLASRDSFTNEHLEIFDLSRLGPPPSSAAVQPPKRKIEKITDSETTPSSMEQGTAPLLASRPFIRKLFKSSLQDDKLRLPAVSSCSSNAMATSSTDDKGSSSAGRSVKKQRLSQSSEDTSSLHTSLTHISDASSKSATDDLLGLRSASAAFAPGASAPTPAPASAARSSAVSATVTSASLSHSSAVSASDASASAVRSSVTSSSLASVSAISNSVVAKTTDVSARRIPRRLVHAFPSRSVHSETQTDGPPYSIDRAIAFIRHINDLPLHTTIDDIMTDGCFEDILVPRNTQLNERTVGELTQDPNPEWSRDPDLFYQVSSQTEYNDLMHDYFNGHHPFKKDEVFKNPSSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU37</accession>
    <name>A0A367JU37_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SET5_1</name>
        <name evidence="8" type="ORF">CU097_005355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000698">
        <property type="protein sequence ID" value="RCH93428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU37"/>
    <dbReference type="STRING" id="86630.A0A367JU37"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="91"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="47307" checksum="D26FF78877B2FC74" modified="2018-11-07" version="1">MTDKIIPSEEALVEAIQKIKLETPEAGIKKVTTLVLEQQPSWQVSEKRVKKHMQQCGLTQTTQPVKSGLADDPSVPVSYIDPRLDFKSVSDCVQARMVDPVTGKGLFAARDIKRDEILFTEEPFVYFPPWELFALARSGNACGLCCKPILYANRLTQHCKYCEMYYCSKQCRSTAWEQFHQLECTRLNPAVTKLMNFCEGENWQAPMAIARIYARMILAHQRDELNEVLGHLDAFATVSQEERQAKETEWIFMEHPTRELWAKARDFLSKAYKEPPAKCKITKALPDTLKTQLFDDEKTFLNYMGKFNINNQNGGLYLVHSHINHNCYPNVSIDHPQAKSQYKIAVRAIRDIKQGEQLYETYVNPRWNKETRQTYLDKSYLFKCQCDRCEKDLPLTDEIRNGLRLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU95</accession>
    <name>A0A367JU95_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHS3_2</name>
        <name evidence="13" type="ORF">CU097_003002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000694">
        <property type="protein sequence ID" value="RCH93465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU95"/>
    <dbReference type="STRING" id="86630.A0A367JU95"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="272"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1079"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH93465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1127" mass="126402" checksum="788C3FDAC6C98466" modified="2018-11-07" version="1">MNSTHVARSTSLPKRQRSLIRPERQKNDANNRLYHYHQRAETSLRRGKSILGREEDHEVVNEYDIKSSGFLSNFQPWQTYCTLLTCCIPKQCLRFAGVPDGPAQMAWREKIGLVSFILFIMGCVGFLTFGFTQAVCPVPPLSLKGGQVNTGYLIIDGWAYMLASWDHPIGITNTTINVLYPPINAGGMDATFLFQSPKPQCASIFTPLQGDQPIYFPCQLFNPNQTDPPSPSEFNNRTSCHLSSAARSMYHQFQTEGVPKSGGNQFDKAGRVYYDWQDVLTADSLTVYNGNVLNLKLLHSLPTDYFQVPENGLIAQMMSNPASFAGTDITRMISASADPASKLWEREAQCLSATIKVGSLDTVSIGCMASDIVLYVSLAVILGVILIKFFLAVIFGWFLSWKLGDFNEAGSYAARMQRAAEIENWTENMQASAPLSKPKAYSRKRKTLFPQTSRFTQPIPGSTRFDVTGSMTWKTPNSALEGYMHRQMDGVSKTSVFYNMNASGATASRLLSAEGSSVASSSAEAELPTCPLPLSPHVLRQPPADYMPFNYPLAHTICLVTCYSEGEDGIRTTLDSIATSDYPNSHKLLLVVCDGLITGSGETKSTPEICISMMRDLIVPADEVQPYAYVALADGARQNNMAKVYAGFYKYNDATVNPEHQQRVPMITIVKCGTEQERQKPGNRGKRDSQIILMQFMQKVMFDERMTTMEYEFFNSIWRITGVPPDRYEIVLMVDADTKLFPDALSRLISCAVKDPEISGLCGETKIANKTDSWVSMIQVFEYYISHHQSKAFESIFGGVTCLPGCFCMYRIKAPKGPDGYWVPILANPDIVARYSENVVDTLHKKNLLLLGEDRYLSTLMLRTFPNRKMMFVPQAVCKTVVPDTFKVLLSQRRRWINSTIHNLMELLFVHDLCGTFCFSMQFVIFMELVGTLALPAAISFTIYLIIMAILGQPALIPLILLAIILGLPAVLIVMTSRKIVYVGWMLVYLISLPIWNFVLPTYAYWHFDDFSWGDTRKVAGGDKGNHGDKEGEFNSRLVTMKKWSEYEKERRIKEAIERHLPVPRFANDRKGLEVYQGPLLKRSSERSTGSDDSKIPLTEHDIVNPVSKRAKEDPIPLNVLDHQDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUZ9</accession>
    <name>A0A367JUZ9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_005666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000661">
        <property type="protein sequence ID" value="RCH93738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUZ9"/>
    <dbReference type="STRING" id="86630.A0A367JUZ9"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="33"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="214"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33712" checksum="8A1A854C3EFCE246" modified="2018-11-07" version="1">MSFFSSSAARLTTNTLKRQLRSYSSKIDNIKRVGVIGAGQMGLGIAYVTANVTRLPVVLMDVNSTQTEKGLQFMNKLLEKDVAKNKITEEHAKITRELVSTTDKLSGLSDVDFVIEAASENLTIKTAIFRELDKVCKEDSILATNTSSISITKIAAATNKADKVIGMHFMNPVPVMKLVEIIPGLATSDVVLEKTRTLATAMGKTCTVVSDIPGFVANRLLMPYINEAVMLLESGFASAEDIDTTMKLGTNMPMGPLTLADFIGLDTCLAIMKVLHENTGDSKYRPSVLLQKYVDAGWLGKKTGKGIYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV73</accession>
    <name>A0A367JV73_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SARS2</name>
        <name evidence="12" type="ORF">CU097_003106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000653">
        <property type="protein sequence ID" value="RCH93808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV73"/>
    <dbReference type="STRING" id="86630.A0A367JV73"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="222"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="305"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="321"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH93808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="486" mass="55563" checksum="B9BDB288BA00F1E6" modified="2018-11-07" version="1">MLKQQFAAIQNTFRQQYRQVWKCRYYTTQDDIHRIPPQLNLSHYVKHVESIANSMRLRNYEPDCVYEVKRLSDEKTELEQRAASFRDRRDEINQSIRSASSKQERDEFIQQAKHWKDQLRQVEEKLVQVESDLINQALLIPNDIHPNAPRGPETNAAIVKTVGSPRTEPHLRDHLTLAEGLDMVDFEQAAIVTGSKFYYLKNSGAWLECALIQYALHKAASRGFMPVLAPDIVRTSIAYGCGFQPRKKEASQIYDVSTASMAHSTAPKLCLAGTAEIPLAGMFAQKMLKEEELPKRVVGFSHSFRAEAGHGSAEERGLYRVHQFSKVELFTVTTPSQSEGILQELLSLQEDMFTELGLCFRVLDMPTEELGASAYRKYDIEAWMPGKNGWGEISSTSNCTDYQARRLDIRYLSSQFKENVGPKEVRVPWHMKEKWVNYCHTLNGTAMAVPRVMIALLETHQREDGSIDIPQPLRKWIPGEPSVFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVW7</accession>
    <name>A0A367JVW7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-processing factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRPF6_2</name>
        <name evidence="10" type="ORF">CU097_008478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000619">
        <property type="protein sequence ID" value="RCH94086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVW7"/>
    <dbReference type="STRING" id="86630.A0A367JVW7"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000384">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="813"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="623"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="913" mass="102941" checksum="2221115B63FE486E" modified="2018-11-07" version="1">MFGVKDFMGKPAPPNYVAGLGRGATGFTTRSDIGPARESGIEADPLLSTGKEEGDDDDERYQDPDNEVGLFSTAPYEEDDEEADRVWDMIDAKMDERRKARREAREREELARYRRERPKISQQFADLKRQLATIDESEWAAIPEVGDLVGKNRRKNKLPDRYIPLPDTMIAAAREKSQYETTLDATEQKIGGIVSSAVKGADADDGMLTNFREIGQARDKVLGLKLDQVSDSVSGSTTVDPKGYLTDLNSVVIKSDAEIGDIKKARLLLNSVITTNPKHAPGWIAAARLEEVAGRPVHARNIIAKGCEQCPKNEDVWLEAARLNTVENAKIILGDAVRHLPQSVKVWLKAVSLETENKAKKKVLRRALEFIPNSVKLWRAAVNMEENPEDAKVLLSRAVELVPLSVDLWLALARLETYENAQKVLNKARAAIPTSHEIWIAAARLQEEYGKPDMVDIIITRAVEMLAQAGVLLDREQWLSEAEKCESNGSVLTCQAIVRATIGMGVEEEDRQSTWMEDAERCIAHNSIQTARAIYAHALKVFPGKASIWQQAAYLEKSHGTPESLEELLQRAVKYCPQAEVLWLMGAKEKWMAGDVESARAILEEAFRANPNSEQIWLAAVKVESESEEYDRARKLLELARKESGTARVWMKSVILERQMKDYERCNRLLDEALAKFPTFDKLWMIKGQLEDTQGNTTKARETYNQAVKNCPKSVTLWILLALLEEKLKMVTKARASLEKARFLNPKNPDLWVQAIRIEKRNNNVNVAKSLAAKALQECPTSGAIWTEIIYMEARPQRKARSVDALKKCEHDPIIVTTVARLFWADRKIEKARNWFQKAVQIDPDQGDSYAWWYKFELQHGTKEQQDIVIKRCVASEPHHGECWQSVAKDVSNAGKKTEDILKLCAQKLEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWG4</accession>
    <name>A0A367JWG4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000596">
        <property type="protein sequence ID" value="RCH94276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWG4"/>
    <dbReference type="STRING" id="86630.A0A367JWG4"/>
    <dbReference type="OrthoDB" id="2237541at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="14379" checksum="363EF73B26A73D96" modified="2018-11-07" version="1">MASVKPNRSINPLTRSCRRLLLRGKNTRYIRNLAQLRGEMAGYLKARSAGDDAAIDEALTKMERTKRQIVAIQECSSVFKSMNLRTGVKTSSRSDLTLSHRDLPKFQFVSSYRWNLTKCVIMDNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYD7</accession>
    <name>A0A367JYD7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_013471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000522">
        <property type="protein sequence ID" value="RCH94943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYD7"/>
    <dbReference type="STRING" id="86630.A0A367JYD7"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925274" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="34"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="712" mass="80032" checksum="BEEA9DB1351B8A82" modified="2018-11-07" version="1">MVSSRYTFSLLQLLLALAQTGNAAVRSQPGAMASSAANAADPVSKVSASEEKPLCHNYRTRFADDMRGWQVDDSQQDTYEILDDAIEFKLLPPDDYVRLHDSKNLPYNLFPGRGPTLNSTVYMRYGRMSATLKASATPGSVTAFILMGDGGDEIDFEWIGGASNQVQTNYFWGNSKEYTINGGTHVVKGAPVDAAFHKYTINWQPDKIEWLVDDEVVRTKNKAETCDAAGNCKFPSQPARIQFGLWDGSLETGTAQWAHGPIDWSVPHTITAQARDITVDCNPDYNQISSFSTTSTVLFDSDEHLPSSKKSLQPSPKKSQTMTGFREFKPRDVCAHDASHLPSEDSITFSGNSIEQISISTIRGGLTRASTWVGRSLKSFLKPASNEQIFFNEQSSLFEFQDNYPRALDLGNCDKRLKLHCKILQITNFSSSKTYPYTLNMHVTNNESQSYSGVMKRIGRGVSTSSPHATLSFTVQGQFALECDLNIEVTNSPSIVSRLKKIGKNNSVDIVNEEEEFDNVVTAHLHLDSGDNPLYSFANQGIGRYAIQTSPLQNPSLALELTISFWLEEYDHCPLDAEMQIDHDVLMFCQGGDYLTFYVKGESYPRWIRYWVTYEKQKLVLRLNERREEPIERISLDGLVRVNTYPTNDIQEDIYLGKKHIIILSFGQADEMYLFADSSKSVRYWKCLLESMTSGGSDNEQQHINKRYIWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYE2</accession>
    <name>A0A367JYE2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000521">
        <property type="protein sequence ID" value="RCH94950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYE2"/>
    <dbReference type="OrthoDB" id="2417670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="243" mass="27413" checksum="43B58930CC2B9BE4" modified="2018-11-07" version="1">MNKQQTSLPPISTLLTETAPRIVIEPSSSPLLLPGIHSPNYLSPLLSPLSYASSITRSPSPISPIQTLPPIHGDDPPRPLKQQQPSKTKSSHYLWNTTARYSHSLKEEEEEKPMETPPEPQELDLPPFTQIVLSESGQAILKRRRGRPPTIKHCTTDGKHWTFLTPTVWDVTHHDQSLTTPEKNEYTDDVMSGTMAAFTSSSMDMVLQMPRKKRGRKPKSHIHGHSCFVWKDMTSTNNRVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYR3</accession>
    <name>A0A367JYR3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000504">
        <property type="protein sequence ID" value="RCH95073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYR3"/>
    <dbReference type="STRING" id="86630.A0A367JYR3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="58073" checksum="248B68D688589ED2" modified="2018-11-07" version="1">MPSHIGKGILATVSLLACIYHDRAVFDPKRPDIKTQPGWPLVGNLPILLQYLMQIHDFLLEGFTRLDDMTLTLSALGIPRHVGTIDPRNVEHILKTNFENYIKGPEFHGSMNDLFGNGIFNANGEEWKYQRKTASIIFNVKNFRDQFTEVFMKELQVMQTKIWDVAAHNFEVIDFHEVMYKFTLDSFIMLGFGVELNSLSAKEKVPFAVAFDEAQKNTFLRFVNPVWSVTERIAGLLMPWKASMNEHLAVVDGFAREVTEKRRAQLAAGEIHTDLLSRFMDARNNKGNPLSNDELRDIVLNFVIAGRDTTAQALSWTFYMLMCHPRVEKKLLEEINQHITDVDNLDAPTLYEKIKSMNYAHAVFYEVLRHYPSVPLNQKYALNDDIWPDGTRIKKGDYVLWCPYVQGRSEKVWGADAKLFKPERWITPEGELRRESQGQWPAFHAGPRVCLGQHLATLEALVAITFLLKRYKFSLVPGQDIRYQVSLTLPMKYGMKVMVERREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZB5</accession>
    <name>A0A367JZB5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_012045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000515">
        <property type="protein sequence ID" value="RCH95001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JZB5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1086"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="269"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="607"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="931"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1287"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH95001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1561" mass="176334" checksum="420F293CF09DA9DB" modified="2018-11-07" version="1">MSDSVFAIGTTSALALVTASSSFILTLQRIYFHKSQQKDLSPLQFDTKRDLTVPVTDDTNRLNRLTFSTLVIALLSAFNFYTAVDKDNNSHDWIKVASACVQFIAWLYAFVLVLVSRRHQLPNEWGWILNTHLFIFYFAAWCVAIYNLYNALILNPNDTLIHLLPNVLAVILGADLICSTGSADKGPQFLDEEGRPVIGVESTSIFSFLSFRWVSPLVTYAYNNKKLAEDDLPSLPPLFRGYNLFYIFGASKGKSLVRRIYLANRRAIIIHVTLAIVSSILYYLPAFFINRLLFLIQDMKGEEDSESLRKGFLLVIGVALTLFIIGLTTSQVWYYAASVVQVRIKSMLSIEIYRKTLRRRDLAIDAPKIEDEEDSYDKKDKKDDDKEKKDISSSIGTIVNLMSTDTNRISEFATWWWAVLEAPTELGVGIYFLYTLLGKSCFLGLLVMIVILPLNHYNAKMYAQAQDKLMESRDKRVSLMNEVLQGIRQIKFFAWETNWEKRIMEARATELRHLAVTYLSSVLFTFAWQGSPILVSLVSFWSFTKLEGKELTAPIAFTSISVFNELKFALNVLPEVFIEWLQAAISLRRIQAYLDEGEIDSPTEEDIQTKDITLGLYDATVGWAKPSYSDDATQEQNTGFTLKDLNIEFPNNELSLIAGATGSGKTLLMLSLLGEAVTIKGIVKCPRQPIVDTVSSDFNLSADIDLKDWILPYAVSYVSQTAWLQNASIRDNILFGLPYVESRYRDTLYACALNKDLEILEDGDMTEIGEKGITLSGGQKARVSLARAVYSRAQNVLMDDVLSAVDAHTAKHLYEKCLLGPLMEGRTRILITHHVKLCSKGAAYIVNLDYNVAGTPYGLRELGYLEEEEESVVEEVAAEEKAIEETLPPANDDDKKKPRALVEEETRATGMVKVKYYTLYMKLVGNPFFWFVMTALILGSRGLDITESWWIKRWTQTYESVNSDDIVVQQHHSYVSQSKSFYAYNHQPVIGDNRTWVAEGDNGDDSVNFFLGIYCLITMSNVIVLTLRFVVLFWGVLGANRKLYADLLHRVFRAPLRFFDTTPIGRILNRFSKDFETIDSSIPNHFMEFVIQWVIIISSIITVSTVLPIFVVPLLVVAFFNIWIGVMFVSASREFKRMDSVTRSPLFSHFTETIVGVTTIRAFGATRQFMQQMLKYIDANSRPFYYTWLVNRWVSIRYAVSGALVNFITGTIILLTIKQMNASVAGFCLSFVLLFTDQMFWGIRRYTNLEMAFNAVERVVEFMEIEQEPPAITDVRPPPGWPTQGAIEVKDLEVRYAADLEPVLRGLTFSVKAQEKVGIVGRTGSGKSTMALSFFRFVEATKGSIVIDGIDIKDLGTEDLRSNLTIIPQDPTLFSGTLRSNMDPFDQFEDEDIFVALRRVHLLPQESATSRANTVTSDTTLEAASSNAFRDLNTLVTEGGKNFSQGQRQLLCLARALLKRSRIVLMDEATASVDFETDKAIQKTISVEFADSTILCIAHRLHTVIEYDRILVLDKGNIVEFDSPLKLINDPESVFHKMCRNSGELESLVTLAKSKHQLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZM6</accession>
    <name>A0A367JZM6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bud site selection protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BUD6_2</name>
        <name evidence="5" type="ORF">CU097_011404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000478">
        <property type="protein sequence ID" value="RCH95329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZM6"/>
    <dbReference type="STRING" id="86630.A0A367JZM6"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="346"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="825" mass="94135" checksum="C1E4BBC4CFC64FAC" modified="2018-11-07" version="1">MKRTSSTSSGMSGEIEQVVTKLLRTTKALLEALTQWSNMRASNAEIFEIHDTLEKQFFLVSQAFEEAGVSMNDLQWIPRQLRESVSIAMMEQPSPAALDQYLPRIREVIVHLLHGLKGKQAQLREKDRESRASIRSSSNSDAWNREVPLAALNRGSSTSSNGSQRMMMYPNNSPPLPPMSSPRMNGAEYDTWSGGMPRPSVPTNDLSARIMPKRPYSPPPPPHGSPMMPLPTRSTSSSRQHIPNPPPPPPAPPSNNVNNQPQTFDENDPNTASALAALKRQENLARRSSVRRASMYRGNSDYYSSISSRMQDTPPVPALPKSQLARTVPEEPEENHEEEEKGLTLFLQIGKQVKKTVYQGEISIPALNMLFVEKFNYTSRQNDFPNIYIRDPSIGVSYELTDISEVKDKSVLSLNIDEQEEQKESHKEWVLKLSAAFEEQLKGATQSFTQQIEQVKKQLESSNEALIEQITSRILAEKNNTEEEPTKEEEEKKEGQEEEKKEKMPAQKMYDQGQVKKQLIEIESLKRDLAVIRQLDRERKEETNQIIQEIRAKAASLTKVNEQDIKVISARSVLEEGKKGLLEKSDKITTRLEELQDTIDQLKLDVTQRKCRPSEIQMTHCAKERRELSKDIEEFGTFIAQVKPKWKKTWEHELQTIVKEQQILKDQEYLLTDIKDDLEALSEVFEQLEKIYAYQVSAKPVVREFRVVPAEDGHEGMSSVLKQVATIDVDHERRLRAMEQADKMRQRELANRIDDFEKELVTFVDTKKLKKTGGALEIDRLRKQKDEEILKQIYASKAAGNNTNNNQEPPPETEPETEQVEVNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZY6</accession>
    <name>A0A367JZY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-formylglutamate amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000489">
        <property type="protein sequence ID" value="RCH95221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZY6"/>
    <dbReference type="OrthoDB" id="71260at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.40">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14493" checksum="09ED2C1E699339DD" modified="2018-11-07" version="1">MSHSNRHGCSSSTSSNVIFKPGLLPLVITAPHGGWKKPTTIPDRVKNGSLVLTDLHTAEIAQDIYERIEQHYGHSPNLVVNTISRRKADPNRDIDEGTETEGGRHIWIEYHSRIKDAIEALHRRHSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0P8</accession>
    <name>A0A367K0P8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperone ATPase hsp78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HSP78_1</name>
        <name evidence="8" type="ORF">CU097_000078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000435">
        <property type="protein sequence ID" value="RCH95750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0P8"/>
    <dbReference type="STRING" id="86630.A0A367K0P8"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="356"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="566" mass="63451" checksum="A9B95BFBBC4214A6" modified="2018-11-07" version="1" fragment="single">MLRLSQRSILRNTTSSTITKITRRSLYLNDVKKSCNVKIPSSTIAITLRQQHWKTNSGLLYHSKRLYNGGMPQGGFRLNPNQAQEQQKALEQYGIDLTAMAEKGKLDPVIGRDEEIRRTLEGKLMEKVDIIKAITLSLARRTKNNPVLIGEAGVGKTAIAEGLAQRIISNEVPESIQGKRVIALDLGALVAGAKYRGEFEDRLKGVLKEVSESEGKIILFIDEIHMLLGLGKSEGAMDAGNLLKPALARGQLRCVGATTVDEYRKYIMQDPALARRFQQVMVNEPSVQDTISILRGLKERYEVHHGVRISDAAIVAAALHSHRYIADRFLPDKAIDLLDEACSKLRLQQESKPEALESLDRQIMTIQIELESLRKETDVMSVERREKLKADLETKQKESERLSAIWNQERKKLEDIKRVKEDLEKARVELEAAQRNGNFQRASELRYGVIPGLEKQLPTDTAEEENPESLIHERVTSNDIARVVSHMTGIPVRNLMKGEREKLLHMEDVLSERVVGQDEAIKAVAEAVRLSRAGLQNPSRPIASFLFLGPTGVGKTELCKTIAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1C9</accession>
    <name>A0A367K1C9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_012813</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000416">
        <property type="protein sequence ID" value="RCH95955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1C9"/>
    <dbReference type="STRING" id="86630.A0A367K1C9"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="39"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="497"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH95955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="740" mass="83496" checksum="C5EEADBCCB245E17" modified="2018-11-07" version="1">MTAVDTIPSPSPQRRIIFKKQSSPMMSPGNRRRKDVGDYWLGKTLGKGSSGCVKIGIHKVTGEKVAIKIISKSHLAANASVEKAVKREIAVMKLIKHPNIMSLLDVIDLSDSPNLYLILEYVQGGELFEYLVSRGRLSEKEARKYFQQIIIGLDYCHRHLICHRDLKPENLLLDRDKNIKIADFGMASLQPTGSLLETSCGSPHYASPEIVNGVPYDGSASDIWSCGIILYALLSGHLPFDDDNIRQLLNKVKMGKYKIPDHVSDEAKDLIQRILVINPSKRLTMKQVQSHPWFTADPPPNPTTLPDPPTAAEIGRPVSHVSEIDDRILETLKVLWAELSTDKIVEALLNSEYNMQKVTYVLLQRHANSYWQIDRDDEIRSVASPAKRRRRPITICAFSNSKDSFPGLKGMMTKLAQEKLVPPMSPGIQHHSTPSQSRPTSHTSLRPVISETDNVSASPHVSATTTTTTTLAPPPVPPKPTVIRTDRVYEDYQQKSPWQFAPNSSSNNNQLHTSNIGQSPVISRPSHFYTTPRTASYSPGHENPSYSQQIPIAQQPYVQAYFHPQLQQHMNNISHMLSPRVPSHHRRHNNDPEDSQMSRMMHLWQRNKVDPASPLQRHQYVFDRTAIESSSLVWKDPSQAAPFLSPAFDVTPTSSPTTHRHAHRYSFNPPCHYVKPQQHTSPTVATSNNSKRTSWLPGLFHFKQPKVCSLECEARDEREAIGKLSQVLREVTIRIGRWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1D6</accession>
    <name>A0A367K1D6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein of the rab/ypt</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">YPT52</name>
        <name evidence="10" type="ORF">CU097_014417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000414">
        <property type="protein sequence ID" value="RCH95978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1D6"/>
    <dbReference type="STRING" id="86630.A0A367K1D6"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="214" mass="23510" checksum="CD05419477761D96" modified="2018-11-07" version="1">MATKPQNKTYQFKLVLLGESAVGKSSLVMRFVKDHFDEYRESTIGAAFLAQTISLDDNTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKAWVNELQRQADPNIVIALAGNKSDLGARRAIETKTAQEYADEAGLLFFETSAKTAENVHELFHAIAKKMPLDQLADGSRNGRNKNGLNARGVDLENAGNAANGCACKCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3D6</accession>
    <name>A0A367K3D6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="13" type="primary">PSD1_2</name>
        <name evidence="12" type="synonym">PSD1</name>
        <name evidence="13" type="ORF">CU097_010467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000373">
        <property type="protein sequence ID" value="RCH96391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3D6"/>
    <dbReference type="STRING" id="86630.A0A367K3D6"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023387171" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023387170" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="76"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="431"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH96391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="52229" checksum="640208CA67722923" modified="2018-11-07" version="1">MGLHSLLRSSTRHVRSCNIRQRSFHASFVAKEQRPKQQKNTFGRVVDSWNNTQVKWYPIPVALGLAVIGAIQYRHIQQRVEKEDTQKPKYRATGPWQVHVAAALPLRSMSRLWGAFNSLTIPTPLRPAGFKLYSWIFGCNLEEMKNPNLYDYPNLSTFFYRELKEGARPIAADAPLVSPADGKVLHFGIVQGKHIEQIKGVTYNLDALLGNDEPPASPVEHAVLGNVEQLVVDEKEFANVNGIAYTLDDMLAEKDDHQAVRMESSVGEDAVAEGYQAKPKEERALAQLASVDSGMTLKPNHALYFCVIYLAPGDYHRFHSPTNWVVETRRHFAGELFSVSPYFVKLLQNLFVLNERVALLGKWKHGFFSMIPVGATNVGSIKINFDEALQTNRKEDLPLGTYTEVTYKSASKLLGGKPLRYGDEMGGFYLGSTVVLVFEAPTSFKFCITSGQKVKMGEALGKYEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3E3</accession>
    <name>A0A367K3E3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_008394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000342">
        <property type="protein sequence ID" value="RCH96723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3E3"/>
    <dbReference type="STRING" id="86630.A0A367K3E3"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="219"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="424" mass="48266" checksum="B5D340712A74CCD1" modified="2018-11-07" version="1">MDGNDAFSKILETKRRPQSRQSINRLSRVFEPSHLDKPTPPSKPPLLREQIIDEAPLTFKDIRAKFQNESSIPIQPKTHYRPPIPLKPSKTGPTLPEKVIIPARTGPPTLPTKPKLRNEMAEQPRSRPDTSLHMPNVIPRTETGNSSVVSTSSTSSSQYSNKKGWHSSMISSWFSSSSSNNNNTSQQQQEALKNSIRRQPTTETVDSFGTVSPQVTGSKRRKVMTELLETERAYQKDMSLLKEIYYDQAVVCLSRSDVRHLFSNLLDIVEFEKSFVVLLEHSYEQDTIGTAFRESMRTIDSIYSDYCKRHEDAVLRLQELETQAEAQAFLNKCQEQLQGKTTSWDLGSLLIKPVQRVLKYPLLLREILTLTSPTHLDHDDLASALKEIEEVAENINEIKRRKDIVEKIVGDKKKTDINVRETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4S1</accession>
    <name>A0A367K4S1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000297">
        <property type="protein sequence ID" value="RCH97214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4S1"/>
    <dbReference type="STRING" id="86630.A0A367K4S1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="295" mass="32703" checksum="83E1ABCF521DB435" modified="2018-11-07" version="1">MSMLIGIAIVTTSILFIIYKSKGQNSKDSISSFQKQALEAANLKCQEKLWWLPTLIKVYLIGILETIYIAVYKRGLFPSSITKEENEAKVSQLIDRYLESHKQDNQQPIAVITGGDSGIGLEITKSLKRCGFELIIGTRSKELCEKLIGPFSTPKGHVEICELDLADFSSVHSFASQVKSILNGRRIDLLINNAGVMNVPYLKTVDGFESQCQINYMSPTLLSKLLLLHMNTEYGRILFASSSTLYAVNKLDTNTPLTSYSLNGLDHYAYSKSCIAHIAQYLSVSAPSGVKVYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4Y0</accession>
    <name>A0A367K4Y0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FKS1_1</name>
        <name evidence="12" type="ORF">CU097_000144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000298">
        <property type="protein sequence ID" value="RCH97206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K4Y0"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1342"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1378"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="11">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH97206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1501" mass="172186" checksum="B72D533C9C29801B" modified="2018-11-07" version="1" fragment="single">KRGWRKRMETMTDHTRISQLALYMLIWGEASVLRFAPELLCFIYHVAEGYDEGVLSTSDTANVGDNGTVNTSASSATTHVISFMDSIIAPLYAFVRDQSYEVINHHYVRKEKDHKNIIGYDDINQFFWNRRAISNLCLRNNGPMLKDIPEERRYLELEHVDWNRAFKKTFYETRSWSHLLTNFSRVWIIHAVSFWYYMASSVDFMYANKTNAYGEINSQFDLPVKLSIVGLGGLVAIVLLVASTLAEFMHLRLSLRTLRILSTRLLLLLIIGACHVAATFYILKYDHASKRALVISSCQLGLGAIFTIFMVVTPPACMFNLPGTGQMLSKTFTANFPEMAEDDRFLSFLLWICVFTCKFLETYFFLVLSFRDALSVTIRMQLHNCSEDPLLGRRLCLIMPIVTTFLMFTVELVLFFLDTYLWYVIWSTIFSVFQSMRLGISVMTSWKSLFVKVPTNMFKKLTIAAKEELSAPLRRMACSQMWNAIIISMYREHLLSINNLQSLLYQVQVSEDQDGMTLRELHAPPLFDAKKAFRPNDYFPPLSEAERRLSFFAQSLSTRFPAPCSVESMPTFTVFTPHYSEKMILSLREIIREEDSTTRVTLLEYLKKLHPAEWSNFVKDTMFIAEENQDSYRPSDKEDLPFYCIGFKSSAPEYTLRTRLWASLRAQTLYRTINGFMNYSRAIKILYRIEHPDEILGESSSSNPLMADVVHSGDDEILEVKKTDKTEDRLESIANEKFRYLVAMQRYAKLNQEERANCEFLLMEYPNLQIAYIEEELDSNGHIVYYSVLIDGHCEMLPNNKRVPKYKIRLPGNPILGDGKSDNQNHALIFSRGEFLQLVDANQDNYLEECLKIRSIFGEFEQNESRPLKDIYALQSSQSKEPSAPPVAIVGAREYIFSENVGVLGDVAAGKEQTFGTLTQRIMAKTGSRLHYGHPDFLNAVFMTTRGGVSKAQRGLHLNEDIYAGMNALLRGGRIKHTEYLQCGKGRDLGFCSILNFTTKIGTGMGEQLLSREYYYLGTQLPLDRFLTFYYAHPGFHMNNIMIIFAVQVFVFCMTLIGAMAAVLPHCLGSNCFDVHPVYDWLQRCIISIFIVFFIAFLPLFMQELTEKGTGRALLRLVKQFLSLSPMFEVFVTQIYANSVVSNLSFGGARYIATGRGFATSRLPFSVLYSRFAHPSIYFGARTMFMLIFVSLTLWTPHLIYFWATVTSLLISPFVFNPHQFVLMDFICDYQEYLGWLSKGNADYYHEHAWVTFCRQVRTQVTGNKKKARMKSMVQDNKPIVAVPRAHLSSIFFTEIVMPFLQTALCLFCYIFFKSREQVDVYGALINRVNTSLGPAGSLGRILGIALGPIIFNAIVLILLQVVSMLSSIIFENSKRRGYYIAIVAHGLAVIGLIFFFELFWAIEKFEVRSTLLGLLAIFSAQRTIFKMVLSIFLTREIHHDATNRTWWSGNWRSSKVGGLAAREYVCKIVEMSVFTADFILVPPKVIPQFSDRYHHIIKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5B2</accession>
    <name>A0A367K5B2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000285">
        <property type="protein sequence ID" value="RCH97345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5B2"/>
    <dbReference type="STRING" id="86630.A0A367K5B2"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="383" mass="41783" checksum="A567F1B6885C0607" modified="2018-11-07" version="1">MSSGFGTRAVHAAQRPDPTTGAVIPALSLSTTYKQSAAGVHTGFEYSRSGNPNRNNFEEAMAELEGAKYGLAFASGSATTATIVNSLEKGAHLISVNDVYGGTYRYFTKVANKLGIEATFVNLSDPANIEKEFKPNTKLVWIETPTNPTLRVIDIKAIAERAHAHGARLVVDNTFMSPYFQNPISLGADIVVHSVTKYINGHSDVVMGVAVMNDKETYEQLKFMQNSLGAVPAPFDCFLARRGLMTLEVRMQRHAENAQAVAEYLETNQYVDEVIYPGLPSHPNHELAKRQQRGFGGMISFRMKGSLDNVNKFLQNLHHITLAESLGGVESLVEVPAIMTHGSVSAEDRAILGITDTLVRVSIGIENKEDLIADLKQALEKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5E8</accession>
    <name>A0A367K5E8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mug60/KHD4 KH type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000277">
        <property type="protein sequence ID" value="RCH97444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5E8"/>
    <dbReference type="STRING" id="86630.A0A367K5E8"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug60/KHD4 KH type I" evidence="1">
        <location>
            <begin position="252"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="412" mass="46931" checksum="B8502E4FF0B24ABD" modified="2018-11-07" version="1" fragment="single">MALSFCYAPPISTQYIFDNQDEPTTVQKVREACQHISLARGCQINLVTNTKIKASMPLLDTPGFGYNISMTGGVQDALLKARGDLLNQSSLKIKMTLQISLVSDISADLFTDLVNLLNVKINVIPPKQHHSSLLSDNPTRIEMIGLPQQVEECRVRVLVLLDEKKNNLKTDVVELPLKLHYLICGRKRCGLLPIIEETSTNIYFPSPFLQRPYEDDDYKAKIYITGEKSSQVARVKDMLNKLAVQKAKSMYHKDTDLSSRKIDWLLLHRRDDLRKIMHDNGAYILFPPLGSGKTKVTVYAENRVNAERTLRSLNLQACSIYEASFYFNHTEDSESLENRASFFNSPLHLATFVSDLSRISGSEVLYRAEQSCIEVLGSERAIRNVYQRLQEMQFLQIFHHQTIFKVESSNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5H5</accession>
    <name>A0A367K5H5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000280">
        <property type="protein sequence ID" value="RCH97406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5H5"/>
    <dbReference type="STRING" id="86630.A0A367K5H5"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="4">
        <location>
            <begin position="82"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="244" mass="27551" checksum="4CA736AEC73F2588" modified="2018-11-07" version="1">MSFRILSRALRSAPRTTLLSTAIIAPRPVVTVPILQNVRTYAKKSKDNKKSKAEQDVGAEVKEPLFNQDQFEARFDQCVQSLKEHLSNIRVGRANPSLLDAVKVNIEHSNFPLRDLAQITVRDPQTLMVMVHDTDYTASVDKAIRNAGLGLNPIVESKGIRVPIPKPTKESRDKMAKLVNTTGEQTKAKIRSIRQDGMKLLKEDKKHQSADDIKKMEKLVQTMTDKYNKLIDDLLKVKSKEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K602</accession>
    <name>A0A367K602_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000264">
        <property type="protein sequence ID" value="RCH97600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K602"/>
    <dbReference type="STRING" id="86630.A0A367K602"/>
    <dbReference type="OrthoDB" id="2289241at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016827393" evidence="2">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="40535" checksum="C8610A9726306606" modified="2018-11-07" version="1">MQTKIVLSLALATVLVQAQVNGNARGHDVHGIAHVNSEASLLPAVKIGTGSLNGKLRADSNNSYRNRNNNKNGRARNGYNEDDEDDKDDEDDEDDEDDEDDGEDDHDNDDDDNDDSDNDDDDNDDDDDNDYEDDDDSDNDDDHEGKYNHYRGGNGRNGIRNNNGRKRDEYSNGHKYDDREGSKDVKGDDEGFGHHGEAGTKGLTGHIKANSFTPQVANIYKSDDKEEKTEKKDKKDKKKKSKDDEDEEEDEDQKKSDKKKKKTEDEEEEEEEEEDDYTNQENNTLEAVVLSMSTSSKAISRSASAAPSGSRSLSFAAAPSATLSKAIPPNSRPTTGGNAKVQSSKSGASFVRVSLGATVGAAIIAAFTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K611</accession>
    <name>A0A367K611_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000264">
        <property type="protein sequence ID" value="RCH97596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K611"/>
    <dbReference type="STRING" id="86630.A0A367K611"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016587698" description="Phospholipase B1, membrane-associated" evidence="2">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42381" checksum="D6EEE55223F83E02" modified="2018-11-07" version="1">MKLTNFLLFLLGFLVALVSALSFPDISQCPPLPQRPPPESVHDLRPDDIKVIAAMGDSITAGLAAINVKTKYVSPEQFVEFRGKGFIMGGDPDSNSIANYIKHYNQDLVGASVGSNKARYCKETFFCFEPYHNYPVDQLNAAQTGSTSSGLDDQVQYLLKYIGPNTPLAHEWKMIHLYIGYNDISAHCLPGMTPVNYGRNVYNNLKTLINNVDKAFINILSVQHFNELIQIPPKHPGYVKQFADKSINVHDHECICCSNGGLERMGKQVDMYNEQLKEVVARLNRELAGTLIEDLLGIKRQKDVAVVYQPLDTYSATVPVDSISNLDGFHPNIKTYKFASRLLWRQLFTKKQDKVLISPFDENMPVYCPTAEDRLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K627</accession>
    <name>A0A367K627_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000262">
        <property type="protein sequence ID" value="RCH97627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K627"/>
    <dbReference type="OrthoDB" id="10435772at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="10097" checksum="91AE5BC5EAEF07CD" modified="2018-11-07" version="1">MSSVEQPVRKIQCTYALIPVRHHVPSQRRTHYLQPQAELKRSKTKRYNKMGVANLVTIFGLTLMGNEGDSQFDLAALSAQDAQRLTDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6J9</accession>
    <name>A0A367K6J9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000243">
        <property type="protein sequence ID" value="RCH97844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6J9"/>
    <dbReference type="STRING" id="86630.A0A367K6J9"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="227"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="476" mass="53500" checksum="661B9DF11E53F903" modified="2018-11-07" version="1">MLVLSQLQNQQEDFIDIINILTKNSKAIVLLPVSIPSHPSAIVDHEFIMDHILIPMKEEEESDQMISPSGIHSVIEGDQLIIANLIESFDIHQLSKKSLFSLDTSHMKNHPRYTILASHIQLPLQDQQINVILIQKPISRKEIMDWTRQDALKGLSTSDKVEKFIKQFKKNPPRTTEGANKTFLDFMQELHQDASDDDDDTSLDKIESLLCEQLYDYFFTDPHGDEAMQGEALESRIAAFNLLDLDLSHLGVSLSQEEMNTIVKLAGAQLQELNTIKGPKEKLDAIIKTHQIITETVQQDAEKKELLNTDILLPLLIYTIVKTNPKNLLANLKFIQQFRRPDQLRGQSGYCLTNMMAAVSFLETANLVGLGLSADKVISHVADLQNSKTVTPSSAKQSSGLKLMNDVVDSSYKAVFEGIGKLWQRNNNSNNIRYQDGPITKFLEMKSVDELKIGEVTELLADYKRLAAIIKQAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6M0</accession>
    <name>A0A367K6M0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coth-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000249">
        <property type="protein sequence ID" value="RCH97779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6M0"/>
    <dbReference type="STRING" id="86630.A0A367K6M0"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016669720" description="Coth-domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66446" checksum="6838240D1D5C0A64" modified="2018-11-07" version="1">MKLKCLALLIGTLILVSAQGESENKHIKYNVIGLLSTSQSMGVIVDNVTYPLELSLPSTILYTGNAPIAKQGYRYTKIIKIDNSTISEPFLRPPIETNTLNEFFNRTWNKKQTVSLPTVYKPLSSIHRISSNLHHEGEIPTIHIIANESEIAAMHNNYTQDIEVKASLSYVSLNDSLTFKNVGFSISGFSSRWMLKASYNIKLNKEDTIYGYRRIKLRAMATDPSYIHEKVAYDMIKSVGLISTDFSYCRVFLNNQEIGLFGLIETFQDLWTANVFADGDKDYKSGNLYQGTGQGMNNTGGLKYLSNLTEYGNGLYKAKAGNKEDYVPLQELTKFIADAPVSGPDAVATWKSKLDMDSVIRAMALEILNGYNDGYIYNANNYYFYQDPSSNKYIYIPSDLDMTLGFALGDIRPLITGNYSTFPQIYNRPLTNKMLQVPEFKQQFEETLVNVTKLLVNPTVTNGFINSLVEMIQEDVAWDAQVPRMGRAIAQMLEILNVPTTNGRVPQDLDMDMLLRAIASPPIVGMNGMNFSFVLTDPVAFNQTRDLFSVIIKGLPLSQAVNGPTDNSAFMGVKDFIYTISQNIANFFNFTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K724</accession>
    <name>A0A367K724_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000235">
        <property type="protein sequence ID" value="RCH97956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K724"/>
    <dbReference type="OrthoDB" id="10379398at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10383" checksum="2274C7039E51CCA7" modified="2018-11-07" version="1">MTRHHLIHRLSRLFRDDGYLRKKKEKPSEKIEIESCSSCTLSTHHVSSITSTSIFEDEPHPKLCLAKQVKAILSGAIELADQELEEEDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8B3</accession>
    <name>A0A367K8B3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_014904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000200">
        <property type="protein sequence ID" value="RCH98400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8B3"/>
    <dbReference type="STRING" id="86630.A0A367K8B3"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="511"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="971" mass="108012" checksum="E016444E1218940A" modified="2018-11-07" version="1">MSKRFQNLNKYRNAFPTVSKKEEWYADIPKGASSSDASSLIQVNHRWIAVKWSGHGGSIGLLPLDKPGKACSNNARVFHAHGASLSDWCFSEFDDSLLATGAEDGLIKVWKINENEDPSCQMSAKTPSRRVDMIKFHPTTDQIVTTLGNDGKKVCIWDIEKSTSTIEISAETPMHSFSWKADGSLMTTSGKSVINVWDPRTAKEPTLSGLGHEGIKGSKAMWLGDSNCIFSVGTDKMRSRQYALWDSRNLSQALVMNQLDFSTGILLPLFDEDTETVYILSRGDSNIRSLQISDLHTKPSIELVTTHGPNEVLYGAALLPKHSLNVMQAEIARVMAISADSIIPISYRVPKKSYLDFDPSLFPHTKGTVPSLTGSEWFEGKTAAVAKVSLDPATLAREKVQKPQVTVEKTAKETAELPINSENQSSEKKSEDRIAGSTTDENKTPKNEALEDNASSDKPFVAVKESAASADKYPETSLPKEKDYIEEKPKPSGLSTSTTKAPPKYGSTGLSAYKYLSAKVYHPSTHFDDLRGLSINKSGDCDLIQANTKFIAVPISGPGGRVGIINARKPGRLPTHIPCVVCGSEVTNFKFDPFDHNRLITISQDNRIRVWDIPEDGIEQDLLDPKFILTDGSMDKLHLLEFHPTSKDVLLTVSQDFNNHTIRIWDLREQSVKLKFDGINKNMVFTCAWNVDGSQIATTSKEKVIRIIDARTGNVLSEGRSHDSLRPSRIVWLDKTNELIASVGFGLGSSRELLLYRTSDMSKPIASQMIDISPSVMSVHYDLDCRIIYVAGRGDRTIHCYEIEDDKFVSLPKIEATSLQQGFAFLPKSVCNVKEIEIGKFYRLTPTTIEVMGVRVPRARPEYFQDDIFIPTLDVEHCAQEASDWFNGINKELNTISLKPEDMELLSTAPPPASQVRAKVKFEMGKKIVSEDERRQQLMDRMFHTAKEVENEAPPVEKEEDPEVADEEWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8P2</accession>
    <name>A0A367K8P2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000185">
        <property type="protein sequence ID" value="RCH98593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8P2"/>
    <dbReference type="STRING" id="86630.A0A367K8P2"/>
    <dbReference type="OrthoDB" id="341353at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21558" checksum="1364E4718ECDCF19" modified="2018-11-07" version="1">MTFLVIDLMIGSLFYPKKIGLLTGWIHHIVYIGVLTWAISQGYCSIFVMMCLLEVPTFLLALGSVRNQFRHDYLFAFTFVFTRILFHAYTILCAFQLRPFGPIMIALAAFFPLHCFWFYGFIKQQLRLSKTPSVPSKKRYYQSMDVTTSRIEEKPQAMDVLKEPTTWHTCKHFSSPAFHASPVSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAE5</accession>
    <name>A0A367KAE5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IMP4_2</name>
        <name evidence="4" type="synonym">IMP4_1</name>
        <name evidence="4" type="ORF">CU097_011662</name>
        <name evidence="5" type="ORF">CU097_014762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000618">
        <property type="protein sequence ID" value="RCH94096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000145">
        <property type="protein sequence ID" value="RCH99120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAE5"/>
    <dbReference type="STRING" id="86630.A0A367KAE5"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="82"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="285" mass="33095" checksum="7AE967CD288DBBC6" modified="2018-11-07" version="1">MIRRNTRLRREYLYKKSLEQKEQSTFDRKQKIKEAIEQGKTLPTELRKMDKGSKEDFGYDQAQEAPSTHEDDEYARAGVYDPKILITTSRDPSSRLQQFSKEMRLIFPNSQRINRGGHVMKEIVEACRANEVTDLIILHEHRGQPDGMVVCHFPYGPTAYFSLHNVVLRHDIKDQGTVSEAYPHLIFNNFNSKLGARITNILKYLFPVPKDDSKRVMTFANDNDYISFRHHVFVKTGNQVELAEVGPRFEMRPYEIRLGTVDLTDADVEWQLAAYTRTAARRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAW3</accession>
    <name>A0A367KAW3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000127">
        <property type="protein sequence ID" value="RCH99383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAW3"/>
    <dbReference type="STRING" id="86630.A0A367KAW3"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="703" mass="79807" checksum="F68669ED5A6FB8C3" modified="2018-11-07" version="1">MVCLGPRKKEKKANGSEERGVKKTATSRLKNSKAINSLTPSVASRKTVASSNRSSLVAPGDSHLPRPTSRTSILASGKSPNRKSPPTSRPTSIAASVKGATTTTTATAKSRISGTGTAGNRASITSTAGNRTSVVSIAGNRTSITGSAASTTKKFPISEMKEEVKDLKAKNEENLKLIADQQAELERLKKQLQEQEHESKQEQLLEREREIEELRSKLEQLNTNPPSNIAQSDKEEELAQKQRLLEQKEAELEEQKRLMEEKAPEIDQVAQQLEELKQQNLQAVHQLADKEKELEELRSLIKDNEAINKEEDKEAALKKIEDLNQQLEIQKKAHEESLRLHEQALAEKDQLLKEQQKAIDELESNHQEELRKLKTAQSFSILALKKKHKEDKLQLEKQLEEARKEAEQNPTADSINEHLEKILQEFEQQEHTHAVQIQDLEESHQHELDNLENHQKDQMNKLKKTQGQKRETWTERYLPTEAVSWPHPANVPKLRPTPTLVESKSKTLLRVLGNLPEYQKPEPVLTPLDPKKVQIYYSSVSANPVIKRNQEQIQQLLTSNNIKFSLVDVASSEAARQYAKRANNNGSSEGRIKEFPQVFVGGEYRGQFKDLVEAIDDEKLDEFLKPAKERQFTDEERAAIQKAELNEELNQQKMMMPPIPTTLPKLKPVNKVKPLKDYDEDEELLKLVEQELMEGKELDFDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAX8</accession>
    <name>A0A367KAX8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coth-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000130">
        <property type="protein sequence ID" value="RCH99328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAX8"/>
    <dbReference type="STRING" id="86630.A0A367KAX8"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050:SF1">
        <property type="entry name" value="INNER SPORE COAT PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="68603" checksum="E7182F64DA432DC1" modified="2018-11-07" version="1">MNLKYLALCMYIFLIDCNDYRQIILTCLLLVIGILTFVNAQGESANKHIKYNVIGLLSSSQSMGVIVDNVTYPLELSSPSTILYTGNAPVARQGYRYTKIIKVDNSTISEPFLRSPIETNTLNEFFNRTWNKKQIVTLPTVYKPLSAIHRISSNLHREGEIPTIHVIANESEIAAMHNNYTQDIEVKASLSYVSLNDSLTFKNVGFSISGVSSRWMPKASYNIKLNKEDTIYGYRRIKLRAMALDPSYIHEKVAYGMVNSLGLISTDFSYCRVFLNNQEIGLFGLIETFQDPWTANVFANGNKDYKSGNLYQGAGPGNNTGGLVYVSNLTAYGDGQYKTKAGNKEDYAPLQELTKFIADAPVSGPDAVATWKSKLDMDSVIRAMALEILNGYYDGYIYNANNYYVYQDPSSNKYIYIPSDLDLTLGSATGDIRPFITGNYSTYPEIYNRPLSNKMLQVPEFKQQFEETLINVTKLLVNPVATNDFINSVVEMIQEDVAWDAQVPRVGRAFADALAALNIPAVNGRVPQDLDMDMFLRAVASATVVDKNRMNFSYVLKDPAAFNQTRDLLTVIAKGLPLSQAINGPTNNNAFMGVKDFINTISQNIAKFYNFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBY3</accession>
    <name>A0A367KBY3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000103">
        <property type="protein sequence ID" value="RCH99742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBY3"/>
    <dbReference type="STRING" id="86630.A0A367KBY3"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="26934" checksum="67F088B31255B72F" modified="2018-11-07" version="1">MFRLTRLATRRTLTKPLIKPPFVYKPFACKSPFDHFTTNYSTDNHEDIEKIDPKDYPELYPDEQDQQIDTEWFVDSDYKVSEEDFIPLWQRRAVGEHLEDRLALRQVSQELMETGQLTAESLRDLLIESKLESVEVLDVREKCDWADYMIVASSSKGDKYLSSVAEHVYTVVKKTLKQSPHVEGRNDNSGWLLIDLGRIIVHLFTPEMRERYDLEGLWKSVPKNEMEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDB6</accession>
    <name>A0A367KDB6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6 7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6 7"/>
    <dbReference type="EMBL" id="PJQL01000072">
        <property type="protein sequence ID" value="RCI00233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDB6"/>
    <dbReference type="STRING" id="86630.A0A367KDB6"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="73"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="659" mass="73558" checksum="34ACBDF1B78A52EE" modified="2018-11-07" version="1">MPPAFDPPYSVPVPGSEKKEGETVPFRHFKFADKLVDHPEGVFTAWDIFVHGYNSAGDKPFMGTRRIEDGVAKEYVWQNYPEVRTRIENFGKGMLHLGLKRQHAIGVYSVNRPEWTMTEIASYRQAFMIVALYDTLGAEAMEYIINQTSMEYIVLSADKLDNIVRLKSQIATISTAIVMDDEVDDAKKAEAEAAGIKVYTFRQVETIGSEVTSESDLPKPEDIATICYTSGTTGVPKGAVITQANCVAAISAIAALGDKGTFADVNSDDIYISYLPLAHVFERVAQGIHLFRGAAIGYYQGDTLKLLDDIAELRPTVFCSVPRLFNRIYDKVLAGVKAKGGVSAYLFNTAFQSKKRHLSKTVHHWLWDRVVFTQIRQKLGGRLRFILSGSAPVSPDVMDFMRICFSAKVFEGYGQTENFCGGALTITDDNTSGVVGAPFPCSEIKLVDVPEMEYFSTDKPFPRGEICIRGTSIMQGYYQLPEKTAEAIDKDGWLHTGDIGQFDSANRLVIIDRLKNIFKLSQGEYIAPEKIEGVYQKHELVAQAFVYGDSMQSSLVGIIVPDKDAFSAWAKEHFPTVEDPYASDEVKKALLKELTAYGKENDLKGFEQMRSVYLTPNEFSIENDLLTPTFKLRRENAKKVYESQIEIMYASLSNGRAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDB9</accession>
    <name>A0A367KDB9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_015333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000078">
        <property type="protein sequence ID" value="RCI00141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDB9"/>
    <dbReference type="STRING" id="86630.A0A367KDB9"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="43"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="440" mass="47912" checksum="486F21387A64FB2B" modified="2018-11-07" version="1">MPSENYATSDTSSDKFSKVEQTAIDRLEEDRASSINEFGHGSGNFMTAYFNVVCVVAGTGTLGLPSAFAKGGWLGILILILAYVMSVYSGIVLIRCLYHQPGKRLHDYKAIGTAAFGVVGYIVASVLHLLNLFGCPALYLVLASGNMVEMLKDTSGSHIAYRTWVIIWGVFLLIPSLIMKTLKEVTAIAAIGAVCTMMAVFVVVIQGPMYRNEHPDELVAHDSVIWTGFPIALSTIAFSFGGNNTYPHVEHALKKPHQWKWAVTAGLSTCVALYFMTAIAGYWSFGTNTESPIYNSLPNGPGKLLSMIVMTIHVILAIPIYSTSFSLEFEKFVNCSEDRLGKFGAWVGRAIIRACTMVILVILACFIPFFGDFMGLIGALANCGLVFLLPVLCYLKLTGVRNKPWYELAFCALTLLLGVVGCIFGTIDAIKALVQDFKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEJ1</accession>
    <name>A0A367KEJ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_013557</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000048">
        <property type="protein sequence ID" value="RCI00644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KEJ1"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1232"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="338"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1062"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1242"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI00644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1397" mass="160676" checksum="8BF351775F35884B" modified="2018-11-07" version="1">MSNLELQRQQFSNSPSFPRSNSSSDISAELKVGARAQIQGKVGFIRFVGTTSFQTGKWVGIELDEPLGKNSGVVQGKRYFDCKANHGVFVRPSQVKIIKEDSTVQSPVPTPSSSRFAPARDPNLAAATSKVSTSTSTTLLPSGISRLPQNNATGLRRPTISGASKKSASPVTGLTKRNSALSKIKPSSPTSSPAIPRSTFSYSQINSEDSPKSPLQGRALYRQDGQRSPSTLSNKGEHDQASMTSESQQETNEEIDEDDIDDNKSETDQEEEEEEDYNNDPSRTQSTQSNRPVLEKEDIVKTTSTTSKTPSNQAPTYGSLAANLPVSKSEQVVPLKDYEELRLKLKILEAKRQEDREKYREHEKVKEEAEQFLTLRNKLQDKIADLQKELRETKRQLKEVSSDQEMYESKYNDAIESLEMMTLDKEVAEERAENLQQEVNVLKDKIEEISVDLDILRKEADIINRIPERDGDEKTPLEVIQLERHNERLKEALVRLRDATTARENELCERIKDLEKEAYELEDVKAQYVKTRDRLQVAELAIEELKQSLDDALGAEDLVEQLTEKNLALTEKMEEMHLVIEDLEALKELADELEDNHIETEKQLQAEIGKDMLLREQMERVRAAEETNMDYEATIQQFRELVSTLQNDLEHLKHKEVSQQSERRTLSSQSQAMMSLNIQLQSTVMKAQAKSIDLELRKLEAQQANDRLSYIQPYLPDAFFKTENDAISCVLLFKRLVFKSELIIKHLDQNHPISERIMDTVPESLISVCEMRQRAGWLSDLSKRFVTFTMNCNPTTFIKMGQVYHDLIGTERRLTGIVDLLRTDEVNEGECVTELQRMIAQLEHLSEIHLIESENNHADQFFGLTRALDLNADRMTVELTFLKQIVENAARKENITIVEGFEKLDYDYLEPLNRLIVQAKNSKILAKKLLRQLEDLTEQALTLTSDYLHRFKMLYAISTKLCKFCFETYKQITRYVETRVGSKEDISLGIIQQTIYNKADEILEIPESSMWEGCLKTLKSLTNELNTTHERISNETKTQKITIGVSPWTQRASDMKAEIVINHDMERKLQQHSDEILKLIKDVKLKDQALQEAHVKIELLEKRMETVKKQAEQIQILEETLSKSQQQEQMYSEAIDNLQAEYDNLEQEHIKLKKEIAQKEEKRLSASKKAELFIEDATLMNSENEENNLDIHNLNSQLESLKCAIRYLRAENAHLKESDVLKTLHMDYTARKTLLPPTPPLTDDEGEDEDEEYENKEPDFKSMVRSVLQETRTLVKDVRLATATTKIVQLSPERRGGKWQRKKNLPDYQYQMQQSVLYTLKRRCESLKEKMKHIQNNERYAKWSQKSALAEKEHNKKLMKAFAKIHFPATAIATEPKRHIQLESFKEFEKIHNLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF28</accession>
    <name>A0A367KF28_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DIS3L_1</name>
        <name evidence="16" type="ORF">CU097_015765</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000043">
        <property type="protein sequence ID" value="RCI00741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF28"/>
    <dbReference type="STRING" id="86630.A0A367KF28"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000021">
        <property type="entry name" value="DIS3-like exonuclease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF30">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="15">
        <location>
            <begin position="467"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI00741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="672" mass="77016" checksum="5A51B7BF4F003849" modified="2018-11-07" version="1">MSLKSDRAFYKKTKGNSIVKLVREQYVRSDIPCLSEACPMNCDNNGSQALLSSSSDHYLIPDISVIMRYLEVLEQEEITGVIYSQTVTANLQQHDRMKLYRKIRQITNDSRRKCIVFYNEIFEETKVHRLPHEPSSDRDWRALCVLAEWYQTHLNDSKKIIILTEQQQDMTCLSANIDVMSTKEYIQRYWGHHVLLNDLIQGLADVVLLEEDEFGKIKFSNKHGSNEAAVSGYTEYKPIEDLEVGIKSGRYFSGTLRCKKDSRDQAYIIGNNGRHIIITGNDHRNRAVHGDVVVVELLSENHWIHPSNDIAYESTNADDEYEDESYVTPSQAAGRVVGILNRNWRSYVATIQEDSAEAGGSIHLAIPLDPVIPKIRIRYHDVKLIENQRIVVRIDNWPVSSQYPNGHFVRSLGPIHTLDSEISAILVEHSISVSQASQGFSEASLKEMPVDTPESPWKPEEEEINKRRDLRNLVVFSIDPPNCQDIDDALSIKELENGKVELGVHIADVSYFVKENYITDLEARSRGTTVYLADRRFDMLPSVLSERVCSLRHHVDRYSVSVIWTLDKHYNIVDTWFGRTIIHSSCEMEYEQAQQLLNGKQVATGLDASLCKKLKPRIEKLAEVLRVIRDRRLSKGALELEGSEIKFKITDKHEITDINILFNIIKDITQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF63</accession>
    <name>A0A367KF63_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000037">
        <property type="protein sequence ID" value="RCI00856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF63"/>
    <dbReference type="OrthoDB" id="2206081at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="307" mass="35540" checksum="2630617D510BA54B" modified="2018-11-07" version="1">MVGMWIAVVVSVRNFSVAYRQYRRTKGFIHLINIAQVVVLFIHRFIYGLVPVFEITTCAFWPLLVSLWHLDYVLVYLTMFKRLLILEAEKDSIWIKWVGFFLIALRFADWPYELAFYSLQRELMVQQVESGANCLAAWGQGVLILNFVSDALANLFLSGMFVRRLYVHIRRAQTVISHRNKVIEYIARKSLVCLTLTFIVNLVMNILKVTEFLGNRSDTFTVYFQVIESTLLVEALRIDHTYLSDKSFCEHCGMIMNSYSNGQKKSGSSQQKSSRLRSPATAYNPSISSDIPITTIRSHHDNYDHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG87</accession>
    <name>A0A367KG87_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000023">
        <property type="protein sequence ID" value="RCI01140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG87"/>
    <dbReference type="OrthoDB" id="2997026at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016825796" evidence="1">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15283" checksum="673F71F88D1ECF53" modified="2018-11-07" version="1">MNKLLALYCLILSVIAYVSADFHISTGVATGGRTGVVACPSNYWNCNCYGKGDRAGVVTDANNSGLGNITPDTNFFKIRKGLCGMGEMNFYKRNDGRWEFYVNNGDGKLLGTCYQNNATKKCTTVLLADKLVCYSYVCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGI7</accession>
    <name>A0A367KGI7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000018">
        <property type="protein sequence ID" value="RCI01251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGI7"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17318" checksum="1DB70472C424E63E" modified="2018-11-07" version="1">MILSSLTLDEKNHSEFGARFLDAADQLAEDLHLSESSDLGYLFDSVIRANTIVEKHHGLFSKTALEGIQKKARRVSRPAAWLLSKKPSGDLESAMDEPKQPDQTRSKSAPGQDTPVICKFNTDNDSKTDVTLSSRDFNDEDKHIFLVRKIERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH14</accession>
    <name>A0A367KH14_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RAD15_2</name>
        <name evidence="20" type="ORF">CU097_005340</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="PJQL01000008">
        <property type="protein sequence ID" value="RCI01467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH14"/>
    <dbReference type="STRING" id="86630.A0A367KH14"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI01467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="734" mass="83725" checksum="4E8C6D7E3A4F5D85" modified="2018-11-07" version="1">MTIGHCVLEMPSGTGKTVSLLSLIVAYQMQYPEKHRKLVYCSRTVPEIDKALGELKRLMKYRRNQGLQEDFFGIGLTSRKNLCLNPIVSKERKGKSVDSKCRNLTASWVRSKVIKKKNAEEQQQTDDPMDVDQPVPLCDFYEQLEAANSPNPIPNGIYTLEDLKDYGRQMTYCPYYLVRRAIPFANVIIYSYHYMLDPKVAELVSRELSKDCIVVFDEAHNIDNVCIESLSIDLTRPMLDASARSIGILSEKIEEIKKTDAQRLKNEYTKLVEGLRDASTARDEDTFMASPVLPDDLLKEAVPGNIRRAEHFVAFLRRFIEYLKTRLRVMHVVAETPASFLQHLKDVTYIERKPLRFCAERLSSLVRTLELTDLEHFSSLQKVAGFATLVSTYDKGFLLILEPFETETATIPNPVLHFTCLDASIAIKPVFDRFRTVVITSGTLSPLDMYPKMLKFEAVVQESYAMTLTRNCFLPMVITRGSDQVAVSSKFEVRNDPAVVRNFGQIMVEFAKIVPDGVVCFFPSYLYMESIVSMWNDMGILNEAWKYKLIFVETPDAAETSLALANYRKACDNGRGAILLSVARGKVSEGIDFDHNYGRAVIMFGIPYQYTESRILKARLEYLRDNLYIRENDFLTFDAMRHAAQCVGRVLRGKTDYGLMVFADKRFARADKRAKLPKWINQYVTDASTNLSTDMAVVVAKKFLRTMAQPYESSQTGVSLWTVKDIERHKSKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHC0</accession>
    <name>A0A367KHC0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p24 complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EMP24_4</name>
        <name evidence="12" type="ORF">CU097_015150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHC0"/>
    <dbReference type="STRING" id="86630.A0A367KHC0"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016883331" evidence="10">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI01623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="22869" checksum="D1AC4DB85C158664" modified="2018-11-07" version="1">MKFSNQAVTPFLFTILLCLGSVSALTLAIEPHKKECFFEYMNHDDSMSITYQVAHGGDYDIDFWLTSPQDTIMATDSHHDQGAYTITAKETGKYTFCFSNEKTSQSTKVISFNTRVHEKSTAVQTDPLKHEIEELADSIFAIKSAQEYIVARERRHRDTVESTNARVKWWSIAQLGLLITVCFLQIHYLKHFFQTKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHN2</accession>
    <name>A0A367KHN2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000013">
        <property type="protein sequence ID" value="RCI01362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHN2"/>
    <dbReference type="STRING" id="86630.A0A367KHN2"/>
    <dbReference type="OrthoDB" id="2221171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="19266" checksum="4B44891929ED8FB3" modified="2018-11-07" version="1">MSIETENDTLWLWALINCHLPSPASIQNLRDEQPELPEDIQLELETSSKIQLKNKLKQYAKETIKFEGGKWTQTGTIKKKEEKLPNSTQEIYDVKVLIQATLSWGLTSELNMSKLQLKTLTLLTMATMWRPRSDMGTLQFRDVKFQMKGGVEDEPLSVTLTARSPKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHX6</accession>
    <name>A0A367KHX6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000009">
        <property type="protein sequence ID" value="RCI01452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHX6"/>
    <dbReference type="STRING" id="86630.A0A367KHX6"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016652864" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI01452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="258" mass="28840" checksum="D81B4479A8DD4B2B" modified="2018-11-07" version="1">MYLQYHSIILIFSILLQTIFVDAARKCTDVMTDFTKGHEGWTELSGSKQGWSFTSQGLKMDLIPPKDPQPSKDKSEGGLPYNKNTSPSSPSFQYKDLVQYGRITFELKTAKAAGAVTAAILMAPGKDEIDFEMLGGEPDKVQTNYFYGKNIVYGVNGGNHDVEDTTAGFHKYTIDWNAERIIYLFDGKVIRTVERKDTCKRAVCEYPTEASHVQVGIWDASNPASTAEWAKGPIDWKKYKNKPISAIIKSVKIECNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2Z3E6M3</accession>
    <name>A0A2Z3E6M3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">VPS27_3</name>
        <name evidence="15" type="ORF">CU097_011246</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
            <strain evidence="14">CBS 357.97</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="MG967660">
        <property type="protein sequence ID" value="AWD37099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000452">
        <property type="protein sequence ID" value="RCH95571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2Z3E6M3"/>
    <dbReference type="STRING" id="86630.A0A2Z3E6M3"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="13">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="563"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AWD37099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH95571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="644" mass="71228" checksum="405191D77C5B2209" modified="2018-10-10" version="1">MSSFWWGQSAFDELIEKATSELLPAGQVDLALHLEISDQIRSKKVTPKEAVRSLKQRLSHKNPNVILATLSLVDTCVKNSGNGFVKEVATREFMEEVTHVLKTASNQDVKHKVLYLVQTWGIAAKGNPSLSYITGTYSLLKAEGYAFPPVTEKIDSIFLETAVAPEWTDSDVCERCRTPFTLTNRKHHCRNCGGTFCQQCSSKNVPLPHLGINDVVRVCDGCYIKVKLSKIADKETVSQLLGTPTTTSASTSSSLAPVYAPSTSQKTTETAKDDDQFEEDLKKAIEMSLKESQQQQQQQKSVSYSSKQKEEEQEDADLAAAIAASLADMKISSASSPSAATSKITNDKSNELSLTDMENIQLFSTLMHRIQSIGGDVSGDQQVNQLYTEIGSLQPKLVTTLNETCQKHERFVQLHQKLNEAVKAYDRLLHQRLSQAHRNSGYDYSYPVQNYYSPVANQYPPPITTAIATATSSQQAYIPPASSTNVNSANATAATSPVSAPNPSVMYPDLGTVATSPPIQYPATQQQPMQYNPSSTQPQFPLPTSTSYPQAYYPPTPAQMNTQYPPVQPQQSIQYPQQAISLSQPQQATSQQQQQQQQHYSQPQPQKIVEPLNTNHYYNQPIQPPQHNQQQQQPVVDEAPLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK49</accession>
    <name>A0A367IK49_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005487">
        <property type="protein sequence ID" value="RCH78006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK49"/>
    <dbReference type="OrthoDB" id="10387125at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="159" mass="18805" checksum="0D49BFBDAFE7CD8A" modified="2018-11-07" version="1" fragment="single">NAIEKTLRILLKLHLQPKKERIRRKYINELQTTSDTSHTVVTENSIFSRNKKRSLLNKYRKQLQKYQEKNKTTKADKIARKIEHIKELQWKKKPKRKKAVAKVDNTDQDVETVIEEDDEVNISGRRLAKLKGILKSLLYNHDTETINKQDIEISDLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKC8</accession>
    <name>A0A367IKC8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005430">
        <property type="protein sequence ID" value="RCH78086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKC8"/>
    <dbReference type="STRING" id="86630.A0A367IKC8"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="151" mass="16798" checksum="F7E6A37451D028BD" modified="2018-11-07" version="1" fragment="single">MFQQTTDQWGVMQERLAEQQYIPYNARDPNKRARYPGQNNGENKDGQMPQRVPPPNYVCYRCHYINQCPTNGDKEYDKHPRIKRTTGIPRSFLKVIEEPKNAVKAGTGGLMVTSKGDIVVAQADSTAWDKHVAKAATTIGLGSSSAGDLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKG6</accession>
    <name>A0A367IKG6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005380">
        <property type="protein sequence ID" value="RCH78160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKG6"/>
    <dbReference type="OrthoDB" id="10506297at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="53" mass="6127" checksum="7CC320234D174463" modified="2018-11-07" version="1" fragment="single">ENLRKFPEAIIAYGCPSCVEYFQEKGALGEHFFDMGHIIADNSEESDMDDNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKX3</accession>
    <name>A0A367IKX3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005256">
        <property type="protein sequence ID" value="RCH78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKX3"/>
    <dbReference type="STRING" id="86630.A0A367IKX3"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="22844" checksum="116D4A9F9B9977A0" modified="2018-11-07" version="1" fragment="single">TLEWHRQDCNSLFDTGGWNYFTIVTSTTPDHVRVNKLFFLGNTDQHRPQGYDHFRDALVIHSEFLGLYDIPQVQFSLEFSKLLNNPELSDFIIVPSNGQELYVHQVILITRWPHFRNMYTSGMLESQQKRMEIPESYEVVLAFLKYLYNDTLDVNEPCSVVCDLLVLANMYLLHRLKKICCVVLYRHHLTIQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL32</accession>
    <name>A0A367IL32_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL39_1</name>
        <name evidence="6" type="ORF">CU097_001618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005207">
        <property type="protein sequence ID" value="RCH78385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL32"/>
    <dbReference type="STRING" id="86630.A0A367IL32"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH78385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="9120" checksum="1A267D54B56DDFCB" modified="2018-11-07" version="1" fragment="single">GTIPAWYQRERRALPLEQVESLIQMPSQKSFITKVKLGKAKKQNRPLPHWFRLKTDTKIRWNAKRRNWRHTKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILQ7</accession>
    <name>A0A367ILQ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ATP1_1</name>
        <name evidence="13" type="ORF">CU097_001589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005041">
        <property type="protein sequence ID" value="RCH78598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILQ7"/>
    <dbReference type="STRING" id="86630.A0A367ILQ7"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002432">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="12">
        <location>
            <begin position="99"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH78598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="25597" checksum="F5D6122CC24F788F" modified="2018-11-07" version="1">MSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNKNFGYGSMTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSMKLFLAQYREVAAFAQFGSDLDASTQFLLNRGARLTELLKQPQYTPLSIETQIPIIFAGVNGFLDKVPVNKVTEWEKDFISHIHTEHKSTLEEIRSKGVLSKELETKLREICENHTKNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN58</accession>
    <name>A0A367IN58_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_000317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004720">
        <property type="protein sequence ID" value="RCH79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN58"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="18508" checksum="F92CF59A0F3B0840" modified="2018-11-07" version="1" fragment="single">LPWPTLEPKAGERKKRLLPSEILKEIENIDADQLFAKKPANDDQNEMSLQKEDNTDTIQESDTCRKTKKRKERCDKETAKEGKQKEPKGRNKYCETCGKHYTDLQTHIKLPEHIDAHKNSDFSGLDSCLSSLKRKYAYPLPSYMKTSVNPIVDGPDVLFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISX5</accession>
    <name>A0A367ISX5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003731">
        <property type="protein sequence ID" value="RCH80794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISX5"/>
    <dbReference type="STRING" id="86630.A0A367ISX5"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="298" mass="33928" checksum="989C8AD4B7B55656" modified="2018-11-07" version="1">MSETEFDEVTSELVNIKLANFEMGLKYQELCQNHENVLKKLKETQEGQAALVEKIMSLQTTIESLQIDKEKLLQEQEALVTENETLIEKNTVAKKTLADLQLEKMNLENDCQQYKDRVKELEDQRREYLMPRGSFTEEVLAAHQTLFGSSSAAPPMNRRHTVHMVEQEKDKYQAKYIESDLKCRELEKLLAEAKYKLVEYEANAASTPVSSPRASLQQPRRPVSIQTKRSSLSALINKSGPTSPPYTESNYTARESIDSLRSTTSTTSQKRSSIYSRFFNTLSGEPLTEEAQAMTNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITL3</accession>
    <name>A0A367ITL3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003628">
        <property type="protein sequence ID" value="RCH81008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITL3"/>
    <dbReference type="OrthoDB" id="2425129at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="195" mass="22176" checksum="011DC8D214B7F3F5" modified="2018-11-07" version="1" fragment="single">MEFVVDSMPDITLKFSPGECFLKCTNEEYKADACISADENELSILEASGKILLDDNSKYGSDHIKIHYGALSIFNAVYKMYYWATEATASKLHIPFLHARHDMIHLWSLGLCSSKLYFSKKVFKCKVPRDMTESKDILALGNLSWSYKCLLENSVKVIKTMKEEHEEYSLQKILSSGAESRTSLSTLLKLDIQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITS1</accession>
    <name>A0A367ITS1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003597">
        <property type="protein sequence ID" value="RCH81067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITS1"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="120" mass="13706" checksum="6ED19F44A372D4EB" modified="2018-11-07" version="1">MPNPFHEPQIRILKEAFPDIDILTIDEALYSARGDINTAFDMLLEPNSPTKPIHSSETTPFSPINKTKPPTVREELAQWRQELYVESRLKAERDMNRNTNNGSFLSLPSIFSSTHHTNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWI6</accession>
    <name>A0A367IWI6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003167">
        <property type="protein sequence ID" value="RCH82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWI6"/>
    <dbReference type="STRING" id="86630.A0A367IWI6"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="14793" checksum="72FEEEC4C61CB549" modified="2018-11-07" version="1" fragment="single">MSGQSTPNLYNDSSLLLRTRKSDRDLVDYDVKEDKKPAYEVIEMGEVAKWNPNAKQNKRKWTLLQHKSYLALALCMLIFLGFIVNTRSQRKIPNRHQLFFNGTTYFDTTVILLSLDGFRNDYLDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWQ1</accession>
    <name>A0A367IWQ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable isoleucine--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ILS1</name>
        <name evidence="17" type="ORF">CU097_001748</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01003148">
        <property type="protein sequence ID" value="RCH82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWQ1"/>
    <dbReference type="STRING" id="86630.A0A367IWQ1"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="19"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="696"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1036" mass="120060" checksum="2AFB983D4407B55C" modified="2018-11-07" version="1" fragment="single">MSLADLSGQFNFPKEEEKIIQFWREIDAFQTSLKLNQDKPTFTFFDGPPFATGLPHYGHLLAGTIKDIVTRYAHNTGHHVERRFGWDTHGLPVEYEIDKKLGISGKDDVMKMGIDKYNAECRAIVMRYAEEWRRTVERMARWIDFDNDYKTLNPTFMETVWWVFKQLFEKGQVYRGQRVMPYSTGCTTPLSNFESSQNYKDVNDPAIVVGFPLVDDPSVQLLAWTTTPWTLPSNLAVCVHPEFEYIKIHDEASGNKYILMEKRLTMIYKDPKKAKFTILEKYKGADMLNWKFVPMFDFYVEEFKDKAFKVCVDTYVTDDSGTGIVQMAPAFGEDDYRVCIAHGVIDADGHLPCPVDDSGNFTAEVGPYAGMYIKDADKVIQKDIKAKGRMIVQSQFMHSYPFCWRSNTPLIYKAVPAWFVRVSPIVNRILACNDQMRWVPSFVQEKRFANWIANARDWNVSRNRYWGTPMPVWVSEDYEEVVCIGSIAELEELSGVSPITDLHRESIDHITIPSKKGKGVLRRIEEVFDCWFESGSMPYAQQHYPFENAAKLENSFPADFISEGIDQTRGWFYTLLVLSTHLFDKPPAKNVIASGLVLAADGKKMSKSLRNYPDPNLVIDKFGSDALRLYLINSPVVRGETLKFREDGVKDVVSKVFLPWYNAYKFFLTQTAVLKKEFDYDFQYDAHIKKSGNVMDRWILASCQSLIKFIREEMGAYRLYTVVPRLLHMIEDLTNWYVRFNRRRLKGENGLEEAKFSMNTLYEVLFTLCLTMAPFTPFLTENMYQNLKSFAPKDPNVVDDRSIHFLEFPQVRQEYFDPEIERAVSRMQAVIELGRTIRERKNISLKTPLKELVVIHSDSQYHADIKALQSYILEELNVRELVITADEDKYGVKYKAEADWKVMGQKYKRDAMKIKKGLPEISSEQIKEFAKTKELVVAGIKVTDEDLNVIRYFEASDDTMYEANTDKETLILMDVKLYPELEEEGIAREIINRVQRLRKKANLLPTDEISVYYRLAVENAEPFEKILKSQEATLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZE3</accession>
    <name>A0A367IZE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Suppressor of tub2 mutation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">STU1_1</name>
        <name evidence="8" type="ORF">CU097_001141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002787">
        <property type="protein sequence ID" value="RCH83065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZE3"/>
    <dbReference type="STRING" id="86630.A0A367IZE3"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="658" mass="74175" checksum="244CA52DEF4740EC" modified="2018-11-07" version="1" fragment="single">MKVHSAKILTQKDLEKEFIAISKLFVGKETEHNWEKRDAAIRQLRETLHSTHFEEWKSTFVRGIHDVASDVIKTIHSLRSSVALEGLALISDISLLIGECLDLYTIETILTNLLKCCSTTKKIIVSKSNEVTSQFLSRTNYHFKVVSILCKNISDKNTQVRQSSALFLKTVLQTHGQKEQTKLAIGKAESTALIHQSLNKGLSDASPSVREACRQAYWTYHEYWPNEAKKLCITIDTVALRQLEKSNKGKKISPIPLFNRSNSSSSISTTSSSSSKPPTLKRASSNSEVDGKKHHSIPAVSIEVKKNLSIQKLTRLSHISHVSAPTAPVAYKLNRQLSTTHARSQRQTKSDFHHRSALESASILNMLKSNDTNQRCNGIRKLSEKLHNTVYNPSGSISLPPDVPSKLNLLPILMDYISRKDLELEVYQTLMSWESLAGIFVYVMSLNYYAPTLIIADQQCKSSQSKRSDMTAVFSKGLARMKLFLKRNDPGLVMKLLNLLKSTENVQKSKQLDSSVKRDILLFPINKEHLQVGLLEWIDQLACDYLGLAQDEDMETLMEGSRWLNASLQTTTAERWFDVDENVKQLTDYVVHMTTADSTKHQELLQPALQKLIEHLKMINATVFDDVVQSANKDPKVAENSLLQNVLRSIMEEQSTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZM6</accession>
    <name>A0A367IZM6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002800">
        <property type="protein sequence ID" value="RCH83029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZM6"/>
    <dbReference type="STRING" id="86630.A0A367IZM6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016711028" evidence="6">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="70" mass="7480" checksum="C69E61FD9BCA3DAB" modified="2018-11-07" version="1" fragment="single">MQLWKISTLVLLAAKSIYGQDEQAYDYIIAGGGVSGLTVASRLSDNPNVHVLVIEAGPIVEDEFSIYAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J040</accession>
    <name>A0A367J040_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002781">
        <property type="protein sequence ID" value="RCH83081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J040"/>
    <dbReference type="STRING" id="86630.A0A367J040"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="730" mass="82599" checksum="ADCF473E1126F8F6" modified="2018-11-07" version="1">MSGQQTQEDLKEIAKQLSDAYYKILQHSTLSEQTILDALSLLSKHSHDLPLSWFTNEFLDQLFVLKTKLENTSGLLSIVTLLSAWLRLSKDNDHRQKLALDILESILRKDDTTRLQKEAWIGWVALIGKGNHDARVLEGMISVVERYSQKQSLELDAGLAHVLAMTNTLNEFEIEPCQRLLNVYAKHVSARGFDGARALMDALEHATDVRSQEKPQTRAEADLTTLVQLVIDLEDKARLSALAGIVRALQFNQGKNTKKVIKQREKAEKALMEQLSIALTSGHVCQDTLAYIASRCLLQVPEKELAHLPSTDLLHILVSSLLTSALAIQHQEPLSRLINSKESVEEIKAFVDQPLFKQVGRISRTIARIIQIADIRQAEHIMDRLVGFSYNVFIDWDQFIIANIDANLYKQIEEHAWTFLKSVLFSFTVILKSIAVDIPNGQGLVEIPNAAQDTLSIFANLHFITHHLGQGAGRQAYQDTLTNVVAYLLQPDHQCQLNRLLSSAFKEYSQPLYTNDTTPAVELLSTVKQMRLLFFTDLLEQTVKSVDDATLEHQILPVIYPILKWKRVENKDLYESAHTVVISTFLAAKPVCSELSVAYADILIDNFPEPINLDQLRFGFTTMVKALCEIDDALAWFVVNRLIEKIHNLEMVRRAEYLTVLIDMLKPLSLGPFFPSILDEIRAQVQVQTPKMQLATLKIIFDTVSGPGISDMRRKQAVGWYLDLKRELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0G3</accession>
    <name>A0A367J0G3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002662">
        <property type="protein sequence ID" value="RCH83438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0G3"/>
    <dbReference type="STRING" id="86630.A0A367J0G3"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="312" mass="36564" checksum="17BFDE2D5393FCBC" modified="2018-11-07" version="1">MSQLAQDYDINESQKQDLIKLQKKTMMNPVGRVRRPRIRKRDPNHIPRPMNSFLSYRTEMQAVIRKHCPLANHREISKVVAKWWHEASDEEKQVFRNKAEIAKDEHTKMYPDYKFNPKKRKSTSSNKKPKRKTAVAEEESQDKQERQFQENNTERTASVSSFDISPADSTFKTPATFFEEDIKKLDHHPCMQQTNGYDGDIIGYAEGLTYNQTHMTQMHTYTQDERHIGNEYLYQDFVMFSNPSPAVQVTYPYCYDPIMPMVMPSCTACDVAPTSQTLFMPENVYTSLPTTSVISPYLLHPADYWHNSRFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0R1</accession>
    <name>A0A367J0R1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-protein Rab-6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RAB6B</name>
        <name evidence="3" type="ORF">CU097_004724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002631">
        <property type="protein sequence ID" value="RCH83525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0R1"/>
    <dbReference type="STRING" id="86630.A0A367J0R1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19408" checksum="CFECDBE541B329FC" modified="2018-11-07" version="1">MIPLIIPIKRPLVLISYQKQCTWMIEQYAFNYERFRSLIPSYIRDSSVCVVVYDITNRNSFLNTSKWIDDVRAERGTDVIIVLVGNKTDLNDRRQVTVEEGEKKARDYNIMFIETSAKAGYNVKALFRKIGHALPGMENDASDEQKEQLTKVDLTDTSTRKEEASSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1D9</accession>
    <name>A0A367J1D9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL17_1</name>
        <name evidence="6" type="ORF">CU097_006980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. uL22 is associated with the polypeptide exit tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002574">
        <property type="protein sequence ID" value="RCH83730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1D9"/>
    <dbReference type="STRING" id="86630.A0A367J1D9"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000012">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="189" mass="21100" checksum="3DAC4E81A9DE4CB9" modified="2018-11-07" version="1">MVRYAATPANPSKAAKSRGSYLRVHFKNTHEVAAAIQGMKLSKAYAYLNNVKEHKQCIPFRRFNGGVGRTAQAKEFGATQGRWPVKSVKFILDLLKNAESNAEAKGLNVEELFISSVIVNQAPKHRRRTYRAHGRINPFMSSPSHIEVILTEKEEAVPRATDKKVVKLNARQLARNARLLAGKTRPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J298</accession>
    <name>A0A367J298_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trm112p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with TRM9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002472">
        <property type="protein sequence ID" value="RCH84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J298"/>
    <dbReference type="STRING" id="86630.A0A367J298"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000018">
        <property type="entry name" value="Multifunctional methyltransferase subunit TRM112-like B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00065633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14205" checksum="12018055BB2FE27B" modified="2018-11-07" version="1">MRLITHNMLQCHVKNCNTNNFPLRFEDAQVELIEAEFNPDFMANVLNKLDWDALRNTAIQLGINTLPEDIPENAEENEEFLKVLHAVILETHVQQGQMICPNCKHVYKIKDGIPNMLLAEHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2F2</accession>
    <name>A0A367J2F2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002458">
        <property type="protein sequence ID" value="RCH84112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2F2"/>
    <dbReference type="STRING" id="86630.A0A367J2F2"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="37601" checksum="DD25C4C3B0AF6E35" modified="2018-11-07" version="1">MQQPFGESPCQQWRIAFIYAFATTFNSQQSIAPSLFKLPDFTPDQLEVELQKEDSQLVHNIICSCLGNIFNRKNPVESYTKSLQDVVTEKIKTMDIELEKNPLSNQKFNMLSADLKLLILYSMIEWQLQDSQAVRLIIDYYSAKRSQHNPIEVRPIGTDKEKSTYWQFGDSPYIWKVKHKKKEWILGKYDDEVDEILIKLVCKDRQTTEAWINTLSTTHRAEKALSKYVGEHVYPLIEKQEKQKAKLEREKWKKLNPVEPVTTRSYTRKRERVNYNYDDIYTEQDFDEYLPESSSRPSSPDRLAKKPTRSSNRLKGVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2G6</accession>
    <name>A0A367J2G6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRAPPC10/Trs130 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002481">
        <property type="protein sequence ID" value="RCH84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2G6"/>
    <dbReference type="STRING" id="86630.A0A367J2G6"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="1">
        <location>
            <begin position="107"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="263" mass="30346" checksum="E573E1E794A658E2" modified="2018-11-07" version="1" fragment="single">VESSLRNMLQQKLKQHTLDQHLPYIFEKIKEEFLKSVDYVGYGLTDVVQLNDFDAELCESFLLHRDLKTKVELLDLIEEFFEENVAVTAQTIKQHSTNLNLHSITFPLEVPKTKILHTAELILPPKKDLLVTEAYPCILRIKQSTYWNTSTTDEETHKDEFCYDIDVDYENWLLSGKRRLRFVSKPGEVNEFSISLVPLRTGNLLLPSVRVSAVSPEIFASTVYLNSAQQILVKPKSRTATFFVEQQQRFIQPSSQGSFNTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2J6</accession>
    <name>A0A367J2J6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET and MYND domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_007700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002448">
        <property type="protein sequence ID" value="RCH84146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2J6"/>
    <dbReference type="STRING" id="86630.A0A367J2J6"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48579" checksum="F003E5101E147824" modified="2018-11-07" version="1" fragment="single">MTIEALHKLTPGHISLCGWDTTDKRVELLGANVINAREKIVGDHVVANEKLKQGVTLLEEEPFIRQLEESYKPTHCTYCFTLLKSNLMKCPNKICKWSHNYCSSTCQRQHWWTEHKWLCAFPELKNTDRDVLFAFQGYIASRSRGKGTLPGLVSNIEFHTSKQVEEYRSRIKNELLSKIFNLTESVLESMVTIMGQIRCNTFAVTQTQTEQAYGSVVEGSYHIAVGRAIYLHASKFNHSCDPNALVLFGTNGCATHLKVNLVRPVEKGEELNISYGPLATKMTTELRREKLYNDYFFECNCSACQKCDDAANMYQCVQCRDQKLYYRQDKCPSCNFIPNWHEISLDEEKAIKLVKEGHVEMNIEKFKQAMRITLKYFDKDSIQMSKLWDNMGRMYVAMGRLSEASKCIKASLINVQKIFGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2U7</accession>
    <name>A0A367J2U7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002415">
        <property type="protein sequence ID" value="RCH84262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2U7"/>
    <dbReference type="STRING" id="86630.A0A367J2U7"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="303" mass="31602" checksum="1C1C526DD4E29EE1" modified="2018-11-07" version="1">MSYNNYQNQGEAASYLGQSNQGYHQENQYHYAPEESSHEYNALLSNIMGNTSSHQPAQDHEIRTAQQHYEQVINNRSQNNSAEAVGNAAAVQALQRSQQTGGGMGDMIKMAMSIASNLSGSGQSTGGGGSGAGKSQAIQQAAMMAVKLYMSKQSSGGGQHQAGAGGALGGLLGMLMGSSGGSGQQQQAQHSSSGMGGIGAMVGSLLGGGGHSQQSGQQQQQQSHGYSQPSNNNYPPQQSYAQNNNNYYPPPQQGNNAGYAQQAYGQPQQSYGNQAPPQTQQHQSQGGTDYAALASGLMNKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3T1</accession>
    <name>A0A367J3T1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_000959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002329">
        <property type="protein sequence ID" value="RCH84575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3T1"/>
    <dbReference type="STRING" id="86630.A0A367J3T1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="366"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="955"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="961"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1150"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1176" mass="133926" checksum="C3BF50F93EBB73D1" modified="2018-11-07" version="1">MPELYTPYKEALERYINASKVRPPQKMRQLIADIRKLANAEKYESHEIKVQPKYINGGTLMPHQLEALNWLLFQWENKQSCVLADDMGLGKTIQIISFLHVLFRKYNIYPFIIVVPNSTATNWIREFRKWAPELVVVPFFGLGASRRLALDNEIFDKNMNLKCHAIVATYESIQESSKLQNIFWPVMVVDESQRLKNDESQLFRSLCRFNKDHSVLLTGTPLQNNLKELFNIMNFIRPDEFEGTQAENYEELTREQVEELHGRLRPYFLRRTKEEILKTLPPKYEIIVPLSMTPLQKEVYKSCLSRDIESILGTNAYKRSKGLASIFMNLRKVLNHPYLIDGVETPQSTPEDTQKAMIDACEKLKFFHQMLPKLRSQGHRVLVFSTMTRVLDVIDDYLTHEGIPFARLDGSDSERERVRSIDAFNAPNSNLDVFLLSTRAGGVGINLATADTVIIWDSDFNPYADLQAISRAHRIGQRNMVLIYRFMTRLSVEERILQIGKKKMALEHVVVEKMKAVEDDIEDIESILKFGAQALFESDDSTNITYDSAAIDKLLDRNQYKAAAEAQKEREIAESEKRKNFSFSFAKVWKAEGGTEDLQEEPDDDAARADFWEKFLQNKQEEIERKKAEKKLLAQNLGRGARKRTKVSYNEKNLNDAAIKKSKKVKKNDKGMESDTEYLFSDREDEDTAELMETETLGGLVVSDAAPPEEPVKLKKPRKSRAKKRQPNTEPEPEPQLEIVDENEYTKMLVMRQQLEHDRREQRMREEQIRMERIRQENIRQEQIRVQRFLQILSLQPAPGTSPRVDVNYAVRLSEVVQSYFVKHSEVVQSYLVTCGQQKIPKPVYDTSVNASLTQLGSTIYKEFETAISMEIEEWKKVGVEKNVLDSYVHAKRVTFKSTFEAAMTQFQQWKSHNEPLLIIMGSSHGDLEKIYKEQGTHALQQALSREVNKAITGANTNRHSQPVSVPQTSSPAVPRSISQPVSQPVSQPIPQASSQKFSTVVSQFLSQATPQFLSQIVSAAVNRQVTQSIPHPTSQPISPVKLQSSSQPQRHQAASVGAQTLAEAFPQIFANAKATSRSIAQPASRSISQSASRPIFRVATQPVSQPVSQPASQIAPFPVSDPVAKEKETNSVVNPIVIDEVTDDENYHTQSKTATSSETSTSPQSMANKIKLVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J435</accession>
    <name>A0A367J435_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002284">
        <property type="protein sequence ID" value="RCH84724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J435"/>
    <dbReference type="STRING" id="86630.A0A367J435"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="95" mass="11277" checksum="7E9DBBD2E477FC46" modified="2018-11-07" version="1" fragment="single">PNTIKWMDANEDAFFGFPSIMRFSWKTISNRMNQTRHVEWSEDEDEEPTTKQAIKAMQEKLAKQALKRKRAAKYNHHRRGKVIQSFSLDIEPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J479</accession>
    <name>A0A367J479_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002343">
        <property type="protein sequence ID" value="RCH84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J479"/>
    <dbReference type="STRING" id="86630.A0A367J479"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="319"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="647" mass="75497" checksum="4615CB8C6D282CFC" modified="2018-11-07" version="1" fragment="single">MSDPFKRQEDLSDDDDHWRDDDIGETPTPSIRFFNTFDDNSTLVSGRSSKASTAMESFTSTRSSGRPDDYWVLPPHCTLTDILGTERTRLKEMTRSTGAYMAYNDALHQIDLWGDPLCIDKAKHSLNMIANCIAELDVTLLRKTKKWSRPDQKKYLGEPTEKLSYYSVYYSPSDAISINRIVGNNDSYLNQIRIDCKTYIEYDAQNHVFRLYSNDEANIKTASARLRNWHLRCCRKLEAGMARLMQQPSANLALKYRKLPSEFVLYDYVPPDREQELRDRSRMFETITTGFEANIAYWNASVEDSLISLNDSQQMRGALSKRAKTLDKRNEEVIQRLLDRGLESLRLKDWDIRMKIRFGTIYLLNYPKKEDQTHLTIEEVSDKLFKKEKFKSALAPCMSKSLENFDMLFEYLGTKAQEFSENPKTSFVILAHQYPIAIPPADLRKKDVNRGEMWKTRMEVAFTDKGERGLWSTVTQCTDLVDVSCFNAEQPYSWDLKVQFARSLPYDDVNAPHEKFSKNLKLSPSGRLIMAPVFGYNPKIVKQKTKWRYSWHDFTIEICQEELWDLNEIKRKDTTLPLDFSEFKPHHKQFKVSMYKEQWVDRFAENLRLRVGEAPSWTIRDFLGTEEENVHTILQNVKEFGQILASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J544</accession>
    <name>A0A367J544_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transcriptional repressor proteinral negative regulator of transcription subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NOT4_1</name>
        <name evidence="14" type="ORF">CU097_004688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002252">
        <property type="protein sequence ID" value="RCH84841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J544"/>
    <dbReference type="STRING" id="86630.A0A367J544"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="643"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="928"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH84841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1159" mass="129482" checksum="3A6560E51AADBE42" modified="2018-11-07" version="1" fragment="single">MSSDEEDPDCPLCMEELDIADRNFRPCPCGYQICRFCWHHIKTNLNGRCPACRRLYSEQIVEFIPVSAEEIMRLKKEKKEKDRQTREMRDPTRRQLSNVRVVQKNLVYVLGMSSKYAYADNEIFRKYGKIDKVVISKRSITTNANASVGIYVTFAKKEDACKAIEGLNGIEIDGKTIRASYGTTKYCTYYLRHMACPNPNCMYLHEPGDDVDSYNKDTVAIGKHSNTASTSLNGSTYPNKKLATGPKPATSKAAVAESKPSASTTPRTWAPIPKVVPVSPAVAEAVPETEEPAVTPPMQSKEVPAKAKTAASPVLLKPSKSTTTKKTVAEKAKKAIKVSLEEEEKPALPPTASWAKAQPSVSLHENVITPTHFGPSLSDAVQTIQKPKQSPSLKVKKEKKSKGRMVRLEEFEEAEREAKKATHQPKDLTQSEPSAEINTAQEISTQESLPSAIHDISTPMKASVEIEKDQASFDANSLKEKETRDSSMGSDKEITENDEDIAMNESEAKTEQPIETVKTEAASTMEKPATDSLKADNVEADVQQISNLEEKQLTDADQSNQEHLNEHIALQETSKVDLNIEKKQKEDVFDAQQPAEKEATDLGNVLNEKQDERTKEKVEALACLNEEVIKAFDVATTNETLPENLEKTHGHNEDTAYSNDTQSDVTSSGLSEHIPSPLVAMERLSTLVEQEILTDIIPSSRQQQPLEDNLPKETLHTFENNVSPWPESRRQPIPPPGLPVPPILPEWMSRSFDPFNGQDPSLIAARRLQHSQRMMEASGLFGMNNGFPQHRPPPPPLPNVPHFGFPPNLNENVPGFSHQPPPFPNMLARPPPPSHPHGMMRHHPPPHPHPQEMLNMSRFGGPPHHQHPHHGPIDDTNKLRAEFNAMHLNGNIDELQSRENLRALLPNVNISFSDQQKVKMEEFHHSHMMHRQGMLQRQSDQESHGSTPSSHHMSPLRHGSMPPNLHFHPPPPTPDHLQGNTPPNFFRQNSFRSSNQSVSSVDGNFTQDTNPDVRTEAQNFFGEFLRKAASSHQQESLEKKEEHHEPKPENPLMFQDPAIMSVSVTGNNDANHESNQSTMLQILGGQQPVPSSMVENQQYHIQQPRPVDARFAMNQQRMMSDPSMDERGRDQPFVNNANGNAMFMGMPPSFPPGQPNQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5N0</accession>
    <name>A0A367J5N0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002140">
        <property type="protein sequence ID" value="RCH85274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5N0"/>
    <dbReference type="STRING" id="86630.A0A367J5N0"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="29936" checksum="9EEE9471C904B753" modified="2018-11-07" version="1">MNSRIILTGLSRSRCLRAIPQLRSYAQRNLMTKSHNLWATRFNAQYMPSLLARQQVRSMFIQTEQTPNDDSLKFIPGTPVLGNGTAEFLDVRSSMKSPLAKQLFQIEGVAGVFFGPDFITISKESTAEWQLMKPDIYSAIMNHFTSGQPIVFDEEDLAASDTTIHPDDPEEVQMIKELLDTRIRPSIQEDGGDIEYCGFENGIVKLKLKGSCRGCDSAVVTLKNGIENMLMHYIPEVQGVEQVIDENESVALQEFDKLEKKLGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6J2</accession>
    <name>A0A367J6J2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01002074">
        <property type="protein sequence ID" value="RCH85530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6J2"/>
    <dbReference type="STRING" id="86630.A0A367J6J2"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH85530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="441" mass="49191" checksum="792573922F23E48E" modified="2018-11-07" version="1">MNTVLLRSYRHRPVFSRLAIRSLHLTPIYLGPIKPFLLADIGEGITECEVIQWFVKPGATVAEFDKICEVQSDKASVEISSRYAGKIVKVHYNQNEIAKVGAPLVDIEVDDDSSEEATLTESSSDKSNHDLSKRSPYASTWETPSVRRLLHEYGLDITQVNGSGKHGRVLKGDVLSHVKRASLIKREMKQSVELPLTKTKKEQEKSVPLTPIQKAMFRTMTESLSIPQLGYKDEIELNAMSEYRNSLNKYIASQQDAFPFKKISYLPIFIKSLSVSLHHYPIMNAQLRQQDMSIRYRDYHNIGVAMDTPQGLIVPNVKNVEKKTILDIASEIHRLTQLAQKGALLPSDLQGGTITISNIGTIGGTYANPVIVSSEIAIVALGSARKLPRFDPVTHKLVPKFLMPVSWSADHRVIDGATMASFSNMWKSLIESPALLSSKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6U5</accession>
    <name>A0A367J6U5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002038">
        <property type="protein sequence ID" value="RCH85682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6U5"/>
    <dbReference type="OrthoDB" id="2272203at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7538" checksum="E9A8BF722E99D377" modified="2018-11-07" version="1">MIDFLNKTDKNDILVTIDYAGLTTDPDDMFQFVRYTLGKSQNHRPDLRRQAANISQSRTLHTPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J805</accession>
    <name>A0A367J805_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SPF27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BCAS2</name>
        <name evidence="7" type="ORF">CU097_008756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001942">
        <property type="protein sequence ID" value="RCH86092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J805"/>
    <dbReference type="STRING" id="86630.A0A367J805"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="25233" checksum="083632D5806FCDD5" modified="2018-11-07" version="1">MSERAIEYATRSDVDLDALPYVDRDLDDENTKAEVERLIEQEMRRMKRTEKSSLPTTINLFENDETLKEEFERVQRKQVLDALDTERYELKGPSNEEDIEAWKAAVNNTKSQLESQAGSMFNLELLSKYGANAWRVHNYQLETYLKYIKSNTDRLRNEIIEINKQRKADQTAAAATLASLENKWSDLISQNLQVEIACAALEGELHELRSHHKRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J964</accession>
    <name>A0A367J964_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001862">
        <property type="protein sequence ID" value="RCH86456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J964"/>
    <dbReference type="OrthoDB" id="2243575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="193" mass="22207" checksum="2ED2C81C64F32921" modified="2018-11-07" version="1" fragment="single">VSGIWKDWVAFMQNGENIKKFHPFSTEYHNIIRVVRIASSRPNLDEKLYKQHLEEKKDKLFAIPAITFDYISLVIEATFNDLLIVPFLKAVANVIAKETSSGAEFKMEEAPLIAMKKQLKEDDDVNLYRADSIIKLYSLRELKVLLLETSYHFGSKDKTKASFDHHKGLSALCLCLRQFQTSSTSEQLKCFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9G6</accession>
    <name>A0A367J9G6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001835">
        <property type="protein sequence ID" value="RCH86592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9G6"/>
    <dbReference type="OrthoDB" id="2285917at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="15077" checksum="D75D4FFEF5FB0FAA" modified="2018-11-07" version="1">MSKEAISDFLNTPPSEMVTLGYVLTKQKASLLSLEYRDAPTMQMLYDISRVALEHEIQDEERTVEALLSVCENNQNQFKRIIEAVEEDGSDPKRARKYTNDGLTYNETCIRKYTKQLSNSSMPELLVLPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9M9</accession>
    <name>A0A367J9M9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001830">
        <property type="protein sequence ID" value="RCH86610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9M9"/>
    <dbReference type="OrthoDB" id="2292676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017076108" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="12656" checksum="19F886F9B13509B1" modified="2018-11-07" version="1">MKTIIAVILLAANLLVANAEPDCFKTINQGAATVELSIYTQKCAMISYTGGVITSDVKYNCCGPSGWVRINYADWEKLRSDGKLDGLRYQRPDLTFRKMVDTEPTTISAEQYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB93</accession>
    <name>A0A367JB93_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001717">
        <property type="protein sequence ID" value="RCH87155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB93"/>
    <dbReference type="STRING" id="86630.A0A367JB93"/>
    <dbReference type="OrthoDB" id="2209325at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="179" mass="20590" checksum="D33A4F347F14DC14" modified="2018-11-07" version="1">MLQHRKIPEEQMHVFHSQQTRLEPKHAIPSEDTNPCKLSPIQQNKDMPHSLPHLHTLISTLVKSEIQQEQHENPSISPLTSMLLLEPNRFRQILTNRRDELQTEINSINQLLSQSTLLDTVQNNNVITSSTREQKRSSSQSTGLFDSLLHAIELSNHQPDIFLSHKGNTINKDERNIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD16</accession>
    <name>A0A367JD16_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RNASEH2B</name>
        <name evidence="8" type="ORF">CU097_010828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001622">
        <property type="protein sequence ID" value="RCH87611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD16"/>
    <dbReference type="STRING" id="86630.A0A367JD16"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="7">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="6">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="26751" checksum="78BFD71419AA0789" modified="2018-11-07" version="1" fragment="single">MAFVAFIDKTNQNVDNFVELSLPCPRSNRIAIYFHNHLNQLFEIQRVTGPGRKSSWLIDGNMYKDGAVRFISPIDPLFICLPILERASVGNQFRTLDDIFTRDNVIIEHDEEDDDDDRPIDVHRLTNFVSEDQLKHLCDVQDVGVLVYRLNEDLVLNWLVKKVNRVLENDTFKRSFEQTGQTKEYMKLEAVYTIANYLSQAWFKKLLNKMGLEEAKEEQQNELTNYATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE60</accession>
    <name>A0A367JE60_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001509">
        <property type="protein sequence ID" value="RCH88214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE60"/>
    <dbReference type="STRING" id="86630.A0A367JE60"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF28">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1238" mass="142067" checksum="BDF05CF4BFE294FB" modified="2018-11-07" version="1" fragment="single">DTSILELSSDPNPNYLKYINRSALYRLEHSPDDNFPAQFRDATIMFISLGKLNVATAHGLELAQKAVHTAIRTLVKYEGILQQFAVDDKGATLLAVFGLPPLSHEREAIFAAKAAMELRDCFLGFLDDFAISLSTGVIFNSVLPQGNPYRRDPAIAGDTIILAVRMLKFQFAKKNIVCDFATKQQIGRMCDFEDYGENFVKGKVKPIQIFGILRFAAIKNKRVSAQSQEKNSDFIGYKSEMTEATKFVSDWTESPNNHLLVISGPSGVGKSFFCHTLSRAVHSPETFCCWSSSTEVEKSSKYYLDLPPNPKRRLSYFTGSTHLYDSAYSHGLESSDVSSSPSSTPPSPTTLTTIKETQLSNGNNTSYFSSSRLSPPAEIHGDDIPESANELVEQITRCLRKCGEEEEFLPLFKVVFTTLVDVPDNRTTRRLDVRARDILLTGVITRMIRYVSEHTSLVFISDDVQWADSASIRLLQHIHEHCQKVLLVLATRPMKDYNVTFINKFRATGVSKEIPLNGLGAAEIAEIILQTFQTTSVNSVSPEIVSVIQKRTAGNPLYVKNMAIVLKDFNHVTVIEHTLVPSSTRFDLEDLLGNFDYKRIIKMQFDRVDNSFQEFLTVASCLDQYFTIKEVQSVIKENNIDFKYADEEEVRQKIERYDVYHFIQKVDDHAHETDEDIYTFTHITIPQSIYDMVSYETRILLHRLLAKYYENQLTRENYTKLLPKVTRHYLQTDYLDKQLHYLEALADLNMKSFLLPEATGNLERIVKILNENTDLAVQFGRIHRSDIYRRLGICFTMRTKLTEGERYLFQALDCLGESWPQSEPEFLYKFWINKISQFRHRKMRIFRKFTKDIKKEIGKRVVEIMVQLSNIYFYTGKGRAFVYTCLVGLNACERLEEVGPSYTLFLARNSMLSWLNDEKEQSIFYITQALKYMDDKNDADTLTICSHLCFAAGKFKNARMLLYRSIEAVKTLGVITDCQAFYRSAGLVITMRIFEGTLDNSPEDLLLLKQMADTAHTNGDFEAEIWLGVYHVGNALIVDRLRDCEPYVALLEAHLKQTADYNRIAIHGTLLCYYARCRNYENARKHTKCLMVILPLLTVTQDERVDFISTHDSKNYDRFIEGVARLNHAFQQVKFWEFTQPCLYLARALPYISTGRTVEGFTVLQHGVLEMRFIQEIRFLKAFYWANLGKYAFTPADRFEWTKRAQKDFESLKIASHIYCNPDPANLYSRGRPADLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE77</accession>
    <name>A0A367JE77_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001515">
        <property type="protein sequence ID" value="RCH88185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE77"/>
    <dbReference type="STRING" id="86630.A0A367JE77"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="660"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1270" mass="144501" checksum="D5A233F131F56629" modified="2018-11-07" version="1" fragment="single">MVSIFRVIRENNVQVLNQLIGLATGEISITNYNNDYLSKQDLISLQQQLKAADLKLFDLNKRSTKGRTALHVAATWNRVEIAKLLIDCPLVDVNLQDRENGWTALHRALYMGNIEIARMLLQRHDIDIHIKDWEQLGAFDLYDMTISGTYPKERSLGDNSKEPNEADDDDIYNLSNNVNEPTGGTDVYSWGQNTNYVLGHPDSENRNRPERVQLQLDSQQNSAVNRPPYVIESVMMAKYHMAVLTSEPSHNMLVCGFGRGGRLGLGKDIDTQLVPTPVPWSERIVTAALGRDHTLAVTESGAVISFGSNAYGQLGYETEIGNKKDEAPMQLVPRKIQAQNLKKQPIIGVAASRVHSVIYTNSDLFTFGLNQGQLGYSQSNSSETCQTTPRKATLSIPTKAFMPAKIQQVIANDNATVILTETSDVYMLCNYSQQKLFFPFNAYPSNIKVYKPAVCYVVKLISSGTEYLGALTNLGHVFIWTCKSTTKQSANNKNPTIVSAPQLIWATGRAHLMAMDASIGQYGEVIICTASGRVFMGRPESGKYRFSEMPYIQRCIRVCANSSGAFAAIRSEYPLQPSLPSPSTLKRDLYQSLPHVIRGRELESEINDIKNQMKHDLADIPEEDETSRALIQQRFDEQKKAMVDQAWNDIMQRSIDDRTLDTVFIIEENRRLYCHSSVLATRSHIFKQLERMADKQIGDFKIRLGKGKDGRIQIHIERCELASLLLMFDYMYSDEYEHPMKVFFESPALSQDRAEDTRKIQKDLVDLAELFHLPHLLVSAQSSFNHQSTPSLLHSLQMLMDYRPDVMLKTRDKLIPCHEVILRQRCVFFKHLLAPQSVWTAKRREQQKDCIEIDMEHMSSEIAETIRQHLYLDTDAPDLFEFIQRDTEDTMLQFLLELLCEADALLLERLKLIVENALIPFIKLRTATSILEHADIYCANVLKQRGLEFIKVNLSVFLPSRMLDRLPSSLIHELENLVRLSQAEVCPLATRGDFSSTDMIDATEIEDDEFSTSLYALSRGNATLISTYDEILVTLYPEKPVSNAETKKEQEKERDVDKRVNKSKKAARIPLQELIEDTQTNIAYNWASSPEPTAGVRPSLREILEEEHQTTDTVSKLAKSSLPKKISQKERRKLQQQLQESSSSSSHQTNKHVWGKVAPAPVKSFVKTMEDEQQQQQQQHPQQQKQKQQRDLDTKGKKIYVSEEDLLPPVRETIPTTESKESAYDPIERISSTFSLTPIRRYIKRASLQNHESTIQSFETIQKQQELEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF56</accession>
    <name>A0A367JF56_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001442">
        <property type="protein sequence ID" value="RCH88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF56"/>
    <dbReference type="STRING" id="86630.A0A367JF56"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="124" mass="14595" checksum="B3198969C66B48A9" modified="2018-11-07" version="1">MSKEEKKTSYHLLFDEDTGELTPKTEKILRAIFDNFDKDKDGKWNLKEIQDFATATNGRPFEDSVIDEIIESFEVDDNNNLLFSGFYQMYYMQTVSEPEETLKDFQKHGYDDNLELVASRTEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFQ5</accession>
    <name>A0A367JFQ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ALDH6A1_2</name>
        <name evidence="6" type="ORF">CU097_008145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001445">
        <property type="protein sequence ID" value="RCH88561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFQ5"/>
    <dbReference type="STRING" id="86630.A0A367JFQ5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="57867" checksum="B6F512B5749DD34E" modified="2018-11-07" version="1">MMASILKSGSVLSKQGITSRAFSTQFPLLQRVSGVDTVKNYINGKFTESKTDKWIELRNPATQDLIGYVPETTHEELNEATESAAVAAREWKKTTVLQRQRVMMDLQYLIRQNQDKIAENIVQEQGKTFADAKGDVFRGLQVVEQACALTSMMMGEKMTVAKDMETYSYREPLGVVAGICPFNFPAMIPLWMFPLAIATGNSIVMKPSERDPGAMMMLAKLAADAGVPDGVLNVVHGSVDCVNYICDEPRIKAISFVGSDRAGQHIYTRGSANGKRVQANLGAKNHAVLLPDANKQAALNAIAGAAFGAAGQRCMALSTLVCVGETKNWLPELAERAKKLKVGYGMEPDTDVGPLITVHSKERVERLIQSGKEEGANVLLDGRGIVVKGYEKGNFVGPTIITDVKTEMECYKEEIFGPVLVCLNVDTLDEAIELINSNPYGNGTAVFTNSGPSARKFEHEIDVGQVGINVPIPVPVPPFSFTGSRGSILGDMNFYGKSGLHFYTKPKTVTSLWKESDSEHTRAAVHMPTMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGC2</accession>
    <name>A0A367JGC2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein arp8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARP8_2</name>
        <name evidence="3" type="ORF">CU097_004525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001410">
        <property type="protein sequence ID" value="RCH88771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGC2"/>
    <dbReference type="STRING" id="86630.A0A367JGC2"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="681" mass="76721" checksum="D49B31F94FB944CC" modified="2018-11-07" version="1">MAEQSNSISHTNNYLKNLSQKKYAWMEEAVASFTPKPATDTKPKSPTESRKGNRKGKKRSSSPSLDQDSHLSPKKSRPQTPKQSTTPPKQTTTSLQPKSPGSEDQPLPTATTITITTTATKEEPRKRHKQPRFKYTNFPVKGYNILPTRNITSSFAKTDASFIPGNKAGAEDIVPNSTEEWRDIIIIHPGSRNLRIGLASEAFPITVPHVIARRMNTKLPVNTEQDTELTEKQEEALNEIKSELKWRMKNAKRRAVPNAEGQVVGFNTNAPRETILDHNDPYKVEWTDVENSNRPEYFIGEKAIHFPVSEDSEYRIFYPWRHGTLNEADYSSLNAVLGDLEAIWANVIQSELEIEKSDFKNYNIVLVVPDLFNRSYLCELVTMLLTHMKFKAVIVQQESACATYGAGLSTAVVVDIGAQRTNIACVEDGVCQVDSRMSIAMGGDDVTKTFASFLRVNKFPYTNINLALPFDWRLAEELKEKWCTMNEAEVSIQVYDFFVRTPFQQTTKYQCKVYEEVFLAPLCLVYTDILQPKTKKTVEWASKNVSDDVTEDSNVSSIVKNLMDPYPIDTAIAESIYAASNGSEEKLKRYFSSIILVGGGGKIVNFSKVLEDRILSTVIAQQSFIERVEVLPAPRELDPEVIVWKGATVMSKLDSAKEMWIGTKEWEEVGARCLKDRALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGW2</accession>
    <name>A0A367JGW2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud neck involved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BNI4_5</name>
        <name evidence="2" type="ORF">CU097_011682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001339">
        <property type="protein sequence ID" value="RCH89157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGW2"/>
    <dbReference type="STRING" id="86630.A0A367JGW2"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="32708" checksum="BB924D647F8B224E" modified="2018-11-07" version="1">MTMNEHDMNQIIHEVQSLSIDHNHHRNDLNAITQPCIWENEDKVDHHAVIQSYLDPQCMLHSSLTSLHEKKRLYKMKSALKRVLGLKQKKHQPLPVISHDASLSSDSGCTSTTVAGQSIKSLTMADNDDDNDDNDYDDDTMSQNTSTTAQHRLSICGLPICSFRNKASMAHPKQSMMTKSILKKPNKSTRWSSVTLRRKTQISNLKKRKSHLESMRLSIQFNQYVTVYETYSRQDYDRTSDPEAICTRLTPVIAQEIKQELNHFKLYEMPVHESSRMYTHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHH9</accession>
    <name>A0A367JHH9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001307">
        <property type="protein sequence ID" value="RCH89335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHH9"/>
    <dbReference type="STRING" id="86630.A0A367JHH9"/>
    <dbReference type="OrthoDB" id="5976950at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027801">
        <property type="entry name" value="CENP-P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13096">
        <property type="entry name" value="CENP-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="37590" checksum="551A902E17EB4E49" modified="2018-11-07" version="1">MRKKIAILQQQVERMEGYVADLEEKLKDRKERRQKEANLTNMTPEQRAQYVMEEEERDISDIPDLDVIFEYMLLLGSSTTTDTNDLSQADFLKPDAQLREEAISNPDVVRQTDYSFVKFTRAKNILETRTDSLDDIRHCELSGSSFNQEFTVSFDVLEATMTMCNLNFEVGIRMKMDIGPLLQKIKDTCNILGFFQVLVHYARLTDQRRVLFEKLKRSFENTDITVEALSDSRLQFQGKREDSMALVLNWKMVMHNMNRDSLDANIRDHVQLQLNMDAITPSSWLQKDQSRALDKVNESYINLIKLQGVFKATETIVNKVLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIH8</accession>
    <name>A0A367JIH8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001240">
        <property type="protein sequence ID" value="RCH89696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIH8"/>
    <dbReference type="STRING" id="86630.A0A367JIH8"/>
    <dbReference type="OrthoDB" id="2284112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="128" mass="14636" checksum="5AFC47B5E7019071" modified="2018-11-07" version="1" fragment="single">ENWKTLQRKVSGTNVVTITSGETTVSEEFYDYSFPPRQDDDDDIEEEGEETMSDDIADGENNEEHHDVLHPDMQQFDVQQQQFQQFRRKSIIPVDETVYNELSRHVSLEEVLNQTPGAGSSATNSPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ66</accession>
    <name>A0A367JJ66_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-binding FH2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_010474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001194">
        <property type="protein sequence ID" value="RCH89994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ66"/>
    <dbReference type="STRING" id="86630.A0A367JJ66"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="639"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126986" checksum="1F3361959401D3F2" modified="2018-11-07" version="1" fragment="single">GQEIVLKGLDKLSEHMGEFGRFDAWLKLLEATLDGRGKMGSLVGASEDVRKFAVGGDNQLSDFALSNMMLVNSLVSVIEDVEIRVHLRNQLNASGLDSIMQKMFDFNNEQLKRHISIYKQMSENDMEEMMDIYNETILNNMNDPRECFERILDKVEGTRSYNFFLSALQHILMIQAQGDTQVRYFQILDRLITQVVMDRKGLKNDDFSSTGWSVAMLIDKFAEQDQINKYIQEAKEARLLYEKTVKEKQELETEINLKGDGLVGQLRDKANSLEDLLRISRHTIATLQKKLKDTQREYEMNITALDQQLREIYSKAAAANDDVAANNENSNDTTGHFVLGREEVTRAYDRLKAQAILEGKPENDDYHNLPRAEGLSEKFKSSLQGQLGSGPVGLVIPGTAPLIGSTRRAPSKKAWQAEDGKSDGVKINADIKDQVEQLLSQHEPASSDDHADKPISAMAAELEQKLRQYNNKPVVETVTTASLPRTSSITIVAATPESNPSERESSLSEDDKSQATDQPSSISIPPPPPPPPMPPVSSSLSSKPETSVVRVSSVPCPPPVSSAYVEVTQQNIPAPPPPPPPPGPQNTQLVSNTPEAPPLPGASAAAPPPPPPPAPPGVPMPPPPPGAPTAPLAPIGPSRKIIRHQPNVKTRAIQWTKLHSNAVNRTVWGSSDVDELALEDELENLGIFDSIESLFAQKVVQPKKRVVKEEKKEIRIIDQKKGYNMNIAILARLKHLSLKQITKAFLAVDDSLLTESLLVNLQQYVPTPEEQGKLSVFVKSASEEELEQLSKPDAFCVEMMKIDRYKERVDNLLFRTMFNERHQRLSKHMASVLDASVALKESTSFKELLKLILVLGNFMNGNTFQGGAFGIRIASINKLVDTKGTEGNVTLLHFLVDSVESKIPRLHGFLNDLQECGDACKVTLQDLVKEYNEIRVGLQKLIQELDNHYEEGYEAPEGDNYAQVMKKFRDDAIEKFEELEVRYTSMDVAYRDVVTYFGENPDQMKPDEFFSIFKTFTSSWERAMSDNLSARKKLESREKARLAEEARREKIKAQKLRGVVTSEAISPGVDEDKNIMDNLLDKLRAGELDTSLKRSKQERSAASREKRMQKSESVAILAEDLLKSIQSDEESPLLRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ97</accession>
    <name>A0A367JJ97_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001191">
        <property type="protein sequence ID" value="RCH90013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ97"/>
    <dbReference type="STRING" id="86630.A0A367JJ97"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="131" mass="14965" checksum="45E5FFC18D32D91D" modified="2018-11-07" version="1">MTNAQDIMDIDGPEFISQVNEQIASLRSLDRKDIVDVTMFDIAHDYVKTTHDLHLFNQSLSISDINHFAQIAIVDTNFLISNLKSLQTLLNLAEENIGSLLILIPWVVIRELDSLKERRGSYFVKEGDEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJX4</accession>
    <name>A0A367JJX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HIS1</name>
        <name evidence="16" type="ORF">CU097_008935</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01001159">
        <property type="protein sequence ID" value="RCH90206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJX4"/>
    <dbReference type="STRING" id="86630.A0A367JJX4"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="221"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH90206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="297" mass="32595" checksum="C121A31F21A02DDC" modified="2018-11-07" version="1">MDFVKDLDNRLLFAIPKKGRLYEQCLQLLHGSDIHFNRRLRQDIALCTNLPIALIFLPAADIPKYVAEGNVDLGISGQDMIVENEVSDKVTEVMELGFGKCRLCIQVPVKGEFQTIEQLAGKRIVTSFDAFARKVFEPVDKAAGTKTTINYVSGSVEAACALGLADGIIDLVESGETMRAAGLHDIHTLLETQAVLMSNKNSHHQDLVDKIASRIRGVITAEKYVLCTYNIERVNLARAVQITPGRQAPTVSALDSHEGWVAVTAMIEKKRKGEVMDLLADVGATDILVMAFTNCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLJ6</accession>
    <name>A0A367JLJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PEP1_1</name>
        <name evidence="15" type="ORF">CU097_005059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001066">
        <property type="protein sequence ID" value="RCH90796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLJ6"/>
    <dbReference type="STRING" id="86630.A0A367JLJ6"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834226" description="rhizopuspepsin" evidence="13">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="84"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH90796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="44057" checksum="0043BBE08373DD01" modified="2018-11-07" version="1">MKFILTSCIALALVTLSAEAAPESKKINIPLEVNENYKPNTKAALEKVIAKYSRFGFTTESNGISPQSTNGTVPVVDDGNDVRYYGIVKVGTPGVDLRLDFDTGSSDSWFASTLCTNCGSSQRRYDPSKSKTYKKDGRKWSIRYGDGSSSNGILGKDTVNLGGLAIKQQTIGIAQRESLKFASGTVDGLLGLGFGSLSTVEGIKTPVENLINQGLISSPIFSVFLGKASKGGGGGMQKAAHSTHKLNCCLLEYIFGGYDSTKFKGKLTTVPVDNSIGFWGINVNGTRVGDKITSDPFKAIIDTGTTLLVLPSDVSTPIFHAYNATDNFDGTYTINCDTSNFKPLTFNIGGADFEVPPDSLIFEKKNDKCMASFTLGNVRGLAILGDTFIKNNYVVFNQKVPEVQIARSINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPT6</accession>
    <name>A0A367JPT6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000899">
        <property type="protein sequence ID" value="RCH91947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPT6"/>
    <dbReference type="STRING" id="86630.A0A367JPT6"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08024">
        <property type="entry name" value="GH16_CCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017017255" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="49"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH91947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="397" mass="44691" checksum="4D34823C5DA47BCA" modified="2018-11-07" version="1">MKITLAHIIFLTSASVFGFELNKAAHLIKKPSVQLRTPIHAASSNMTSTTQKNAIESNACVVFEDHFDTLNFKNWQHEITLSGGGNWEFQYYANNRSNSFVEDGILYIKPTLTSDFLGEDALKEGGRIALYSGSPSEDCTDNSNFGCERISGAPAGGVYINPVQSARLRTINSMSLRYGKVEVRARLPVGDWLWPAVWMLPKYSAYGSWPASGEIDIMESRGNVRYPYGNVSTVLSTLHWGPNPYLNKYSLTQAEVHSANGTFADNFHTFGLEWTKEGLRTYVDKQTVLEVDFDKTAWERGKFDEKTTMNPWKGGDISAPFDQEFYLIINLAVGGVNGFWPDHPSKPWNNNDPHAPNKFYDSRQKWLPTWGKGNKRALAVDWVKVWSMEKDACADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQP4</accession>
    <name>A0A367JQP4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_008760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000852">
        <property type="protein sequence ID" value="RCH92272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQP4"/>
    <dbReference type="STRING" id="86630.A0A367JQP4"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="19165" checksum="7B5BA19F60BD1721" modified="2018-11-07" version="1">MFISISPRISLVDVTTETLPLLIELHKLVFPVSYGAKFFQFVLNSGDLAKLVYYDNQCAGAICCRLEKTRPDDYSARMYMMTLGVLKHYRNLGLGSILIEYIMSVASRITYPLVTSVYLHVQVANEMAIRFYLRNGFQIEAIAHDYYKLNENRDAYVLSRPVIRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQS2</accession>
    <name>A0A367JQS2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CU097_013017</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000849">
        <property type="protein sequence ID" value="RCH92293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQS2"/>
    <dbReference type="STRING" id="86630.A0A367JQS2"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016744154" description="Autophagy-related protein 27" evidence="19">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH92293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="287" mass="32138" checksum="3837BC36675AFE5A" modified="2018-11-07" version="1">MKTVFVLGLLFYSSAFALQNYCNSGYKPIGDKSLTLDLSKLNQEFTLYQNKSTPPSTRSVITQINMCDALSISKESQFQCKKGTYICQKVVYNQDNKDFVAEVLTIAGEFEKSKLDAEFKPVKSEADSTKSGYQYSLTLSGGDNGQSALITLECDTSQSREDKPTEPTIVSFHNNVLTLQWKTVFACATEPQEKKPDDGGHQGGNEEPKKEGMSGIRIFFTIIFVLLAVYFIGGAFYNYRVYNARGLDLIPHREFWLDLPYLIRDLIAHIIDSIMSRRRGGGGYVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQV6</accession>
    <name>A0A367JQV6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-rRNA-processing protein ipi3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IPI3</name>
        <name evidence="6" type="ORF">CU097_011544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000850">
        <property type="protein sequence ID" value="RCH92286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQV6"/>
    <dbReference type="STRING" id="86630.A0A367JQV6"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="493" mass="55533" checksum="660F45198CF2DCAC" modified="2018-11-07" version="1">MVTEVALSASNTDSTIHVWDIRSGSSLFSFKQSQSAKGGLTLVPKPGNTFQVGSVVSAQTDRAILNVYQFHKDQIMHKMITSEKMISVAASHQGQYLAAATATGKVYLWHIPTGHLMRMFEAHYRPVHRLVFSHDDATLLTASEDASVNVWLLTHLIEEDRPAPLYSWSDHTLPVTDLYVGHGQLSGARVCTASLDHTVKLWDMATGHLLTTFLFPKPVSSVVLHPSETMIFAACDDKIFSVDLYRRRQDQTYESVGGMGRVESVGIKDHYQDKPNLGAVFSGHKGTVNSLSLSFDGTLLISGAEDGECIVWDVISRQSLRTFGLHKGPVTHVSCFLRPIELQPNAPQNIVPMPWAPLKRMMVTSEEERRSTSLQMIQNTSTDLLNQYQSIEEGTFYLEPERSKIKQASANMKQLKPSDANESLQSQVETLRSELLKVNAHYQKSKSLQKQMYDTIVDKFMSERRENKKRKLQDDEEEEEEEEEEEENEEQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRL7</accession>
    <name>A0A367JRL7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial amidoxime reducing component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MARC2</name>
        <name evidence="2" type="ORF">CU097_007446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000805">
        <property type="protein sequence ID" value="RCH92600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRL7"/>
    <dbReference type="STRING" id="86630.A0A367JRL7"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="162"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="333" mass="38071" checksum="965EB8790CEA4EB4" modified="2018-11-07" version="1">MPTSTVPAVERIHVYPIKSCHSIELQECEIDNLGIKHDRRFMIIDDESNKFITQRKYASLCLLRPFIDVESNTLTLTAEGQEPLRLPLTQDLSQLPKRKVTLWKDTLTVYDMGDQASEWVTQFLVNHREHDRANNHSIDDPVKDDEPVRMTRLVTLEDPKNKVYSRPSHPKLDGIHSAFADWSPVSFGFTSSLEDVNRGLLETGISKGNQIPMSRFRNNITISGTVPWEEDKWLVAKIGEVTFYIVQPIARCTVPGIDQDSGKKDEWDGKGPTDYLKVYRQFTDEPGQGQFCCDVIPLTSGKIRVGDRVEVLEYIPQEYQQKPIKPNVDKDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRV7</accession>
    <name>A0A367JRV7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">VMA11_1</name>
        <name evidence="14" type="synonym">VMA11_2</name>
        <name evidence="15" type="ORF">CU097_006159</name>
        <name evidence="14" type="ORF">CU097_007420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001690">
        <property type="protein sequence ID" value="RCH87281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000803">
        <property type="protein sequence ID" value="RCH92615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRV7"/>
    <dbReference type="STRING" id="86630.A0A367JRV7"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH87281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH92615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="16891" checksum="613919F890D6F873" modified="2018-11-07" version="1">MSDSAVYCPNYAPFFGFAGVFCAMAFSTIGAAYGTSKAGIGIAGIGSFKPELVMKSLIPVVMSGIIAVYGLVVAVLLAGQLSPTSGYSLYSGFVSLAAGLSVGMGGLAAGYAIGIVGDYCVRGYLRESRLFVGMVLILIFAEVLGLYGLIVALILNAKADNSVCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSW2</accession>
    <name>A0A367JSW2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HRR25_3</name>
        <name evidence="14" type="ORF">CU097_012119</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000757">
        <property type="protein sequence ID" value="RCH92975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSW2"/>
    <dbReference type="STRING" id="86630.A0A367JSW2"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH92975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="379" mass="44303" checksum="189085159D753ED5" modified="2018-11-07" version="1">MDLRVGNKYRIGRKIGAGSFGDIYLGTNIITGEEVAIKLESVKAKHPQLEYEAKVYKALAGGVGIPFVRWFGSECDYYAMVIDLLGPSLEDLFNFCNRKFSLKTVLLLADQMLSRIEYVHSKNFIHRDIKPDNFLMGVGKRGNQVNMIDFGLAKKYRDPRTHLHIPYRENKNLTGTARYASINTHLGVEQSRRDDLESLGYVLMYFCRGSLPWQGLKATTKKQKYDRIMEKKMTTPTELLCRSFPSEFAIYLNYTRSLRFDDKPDYAYLRKLFRDLFVREGYVYDYVFDWTTIRAEQKMNSSRDMPQQDVKIDPETNEPVVLEDYFYSVKKDNNQQQQQQQQQQQQQQQQQQQQPQTGTSSFRRATPANHTKPFNHYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSZ9</accession>
    <name>A0A367JSZ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000756">
        <property type="protein sequence ID" value="RCH92979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSZ9"/>
    <dbReference type="STRING" id="86630.A0A367JSZ9"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="375" mass="42116" checksum="7F9C9C982A6BF18A" modified="2018-11-07" version="1">MRKNSYNSVGLMVQCDECEVWQHCECMGLEEPDIPDHYYCELCKPENHLATRLPNGKTKREYSSIGHDKKTPKKRTTLNSREASMSLEDVLAVRNALELYESGQRSPSPVEKKGNDTEVPHEELPPIKEQDESDSEVIAKITRPKKKQLKTSERRTGGGRGKGSKRGKPRSRTSTPQPRDCSPALMDEGTPTSSQHEEPTTNIGTAIFEYFTPESRALSPPAKPRHPHARMSIYEMNRRAAQILEYISSIQIEMATKEPNHIKSTSSIGASAADAITSTTTAAIEITTETVDIDQNGKIDDDVCSLSSASTIPLERDDDLDFHEPEKDDNRSSLEIMDMLTRKLIKFQKRFGTRHQEDEGRITRSREATSYGHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTD3</accession>
    <name>A0A367JTD3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000724">
        <property type="protein sequence ID" value="RCH93232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTD3"/>
    <dbReference type="STRING" id="86630.A0A367JTD3"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="248" mass="27423" checksum="E062F32FBEBD0BDC" modified="2018-11-07" version="1">MLGQNEEQYDNPFARQNETFDFYQDRTIEPDTDPVRQQTEPLINPFANVSGKIGSTESTSYSEPTYDAAYTGEDTLDEPVSVTILRDVKQVGRKLQQVLNPRGDRGVLKDWDLWGPLILCLTLAITLSASVPSNQSVPIFTGVFVIVWIGAAVVTINAKLLGGAVSFFQSVCVIGYCLFPLVLVAIISIFITTVWFRVPSSLMAFAWSTYAALGFLSESKAHLANRHALAVYPLFLFYLLIAWLVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTV7</accession>
    <name>A0A367JTV7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000712">
        <property type="protein sequence ID" value="RCH93325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTV7"/>
    <dbReference type="STRING" id="86630.A0A367JTV7"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="81"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="200" mass="22334" checksum="14B487A67C4512EA" modified="2018-11-07" version="1">MSDEPTRKLLDGIGATIEGSLERVLAESSSELDNGHSIDDTAKLIEFFAHRHVPLYQPRRSLFTSYPSLQQQQQQQSKTAKTKSFMKKYGYAGIGVYLTLGAIDLAATMAVISVKGAQQVKEAENYVVGKMKNWIGLKHTPTDASHLSDEKPSFTTLFVVAYGIHKTILLPFRLSLTAAITPIVVRRLQTWGWIQRKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU98</accession>
    <name>A0A367JU98_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coq1 putative hexaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ1_3</name>
        <name evidence="8" type="ORF">CU097_012634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000684">
        <property type="protein sequence ID" value="RCH93544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU98"/>
    <dbReference type="STRING" id="86630.A0A367JU98"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="470" mass="51839" checksum="DF6E83532BE40C4A" modified="2018-11-07" version="1">MHKLVVATKSRVRTTHFIRAVGFHSNRQHFVSTKEQPDISPLGKIGSSINSIKNSILETTPLKQLVEEETPFTGHPENWSQAIREAQSLVGETDKERAIDPTKLVGRDLGEIKSNIAKLLYSGHPFLNRVAKHYFSGEGKHVRPLLVLLIAQATSIAEKKPSKQNTDYISIDMPISHGLQNIISNGVFDKHVHYTPSVTDQGCTILPTQRRLAEISEMIHTASLLHDDVIDASMTRRNLPSANASFGNKMAVLGGDFLLARASVALARLRNAECIELMSTCIANLVEGEFMQLRNTKDEQGTDKVKKLSTFDHYMKKTYMKTGSLIALSCKSSAVLGNVTDEVANVAFDFGKNLGLAFQLVDDMLDFTVTAAELGKPAGADLKLGLATAPVLFAWEEYPELEPLIKRKFSEKGDEERARDLVYKSDGLKKTLDLATLHCGYAIDALNKLPSSDARSALIQITEKLLTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUH4</accession>
    <name>A0A367JUH4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_002059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000673">
        <property type="protein sequence ID" value="RCH93632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUH4"/>
    <dbReference type="STRING" id="86630.A0A367JUH4"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="445" mass="48758" checksum="F2C71098FCF26D33" modified="2018-11-07" version="1">MADSVIEDTYSNSENKQDLKRPAEEPIQKEAKIAKLDDDNTSDAITNEENKKEDTSDNVQESSEAASVNEEGQSNPNATMEDSINNNKSSDTNDEKMMNHAGQSKREEQHGDQQLSSEPTPQPQEQQTKEPQEKQPEPLPTAEQDGTQVQTNPSQHPHPHSHPHPHAILNITNTPPVPPGMHLLNESQQHQIIQQYVHAQGHDLANFTAASLAQAMVAPIAVPALASNLLQFQNGAVITALPGPPSQLPQPTAIPHPMPEDAQGSKRQSTRNMTNDERRQRRLLRNRQAAKECRKKKKQHIHDMEEKIVQLEQQNALLQKEVEELKNKLNIAAMQGTEGYRLMKEVEELNAKLSMGNIPNTAATMAASSTTVAHPVTTDSSSASVNSSTNKANDTTDTAMSSQARVSVIKEEEQDATCEGPSVTKSEFDKESSESSLSAAQEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUZ1</accession>
    <name>A0A367JUZ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">WDR55</name>
        <name evidence="8" type="ORF">CU097_009695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000691">
        <property type="protein sequence ID" value="RCH93491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUZ1"/>
    <dbReference type="STRING" id="86630.A0A367JUZ1"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="43573" checksum="B735AAEBD3E5BA50" modified="2018-11-07" version="1">MESGKNKPEPLLFEDNIFHLDLHPSNDIVVTGMINGRIKCYQYGLEGHRHLWTSKTFKKSCRGVSFSLDGKNVFGISRDRSIQILDTETGQAIRTRQNTHESPVNSLLIINENMSATGDDQGVIKIWDSRKDEAVMTYTEHEDYISQMTYSYSNKTLIAVGGDGYLSTWDIRKPNVVAMSDQMEDELLSIALMKNDKKAVVGTQEGVLTLWSWGDWGDYNDRIIGHPNSIDAICKLDEDTICTGSSDGLIRLVGILPNQFHGILGDHGENMPIENLKLSHDKKYLVSSGHDDKLQFWDVAHLFQEDPGEEDKEDDDTTDDTKVKPTAPLLEKTDVKDDGNDDDDDSWGTDSDEETTKQKKRKKTQKKESMKPKKKNTKTAAFFADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVY8</accession>
    <name>A0A367JVY8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000623">
        <property type="protein sequence ID" value="RCH94067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVY8"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="94" mass="10543" checksum="1103EB8C52B3A61E" modified="2018-11-07" version="1">MPNRNTSKVVYKSPDDVEYFVIANTDMIDKYRKDKSIPLIDVVQTFDVHTTVAGGNTGEYVRPSKGALESAFGTHKPEEIAKYIVEHGEEKGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWN9</accession>
    <name>A0A367JWN9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FRS1</name>
        <name evidence="17" type="ORF">CU097_006128</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000587">
        <property type="protein sequence ID" value="RCH94350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWN9"/>
    <dbReference type="STRING" id="86630.A0A367JWN9"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000059">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="302"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH94350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="604" mass="68348" checksum="360774C65E63005C" modified="2018-11-07" version="1">MPTVNVDKLALFEALGRNYTSQEFFELCFRFGIELEEDSSEKEIAEKSGAKDTGNVPERPTLKIDIPANRYDLLCQEGLARALRVFEGKAKPPTYKIVKPADGKLQQLYVQPSTQQIRPYIVAAILRNITFTAENYDSFIDLQDKLHNNICRKRTLASMGTHDLDTIQGPFSYEALPPKDIKFVPLNKTTEVDGHQLMDLYAEDKHLSKFLHIIRDSPVYPVVFDANRVVCSLPPIINSDHSKITLNTKNVFIEITATDEHKASTALNTLVTMFSEYCAEPFTVEPVEVVYPDNTTKVFPELEPRKASAKIDYINSCTGLDLEGEEICRLLNRMSLDASVDPKDSNQILVNVPPTRWDILHACDIMEDVAISYGYDNLTKKMPSVNTFGAPLPLNKLSDSVRRELAMSGFTEVAPLILCSHDENFKFLNRVDDNKTAIKLANPKTAEYQVVRTSLLPGILKTLNSNKKLALPIKIFEVSDVGFKDETRERRSRNERHVCATYTSKTSGFEVIHGLLDRIMAMLSTPRIHKNDKSELGYWIEEAEDSTYFPGRSAYIYLRYIDSESHERKECKLGSFGVLHPTVLENFELTNPTTALEINIEPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWZ4</accession>
    <name>A0A367JWZ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000579">
        <property type="protein sequence ID" value="RCH94428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWZ4"/>
    <dbReference type="STRING" id="86630.A0A367JWZ4"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39617" checksum="FE7CE30FBE003FBA" modified="2018-11-07" version="1">MRDPYRTTRKQNDSSKYEQDEFNSRSPSESSMTRLSAAPKPVYQEDYDYYQQQDPYAPNRQKKKKKKTNMEHYYDSEKRANSYLPYSHHKRDPYDPVEPIYLDEELPSFNSPGHRGPVGSILQDNIAMEMVEQDDLHNSTPHKNINSTIQPLTPTKKKRWWTRLGISGRKLVFIVFAFVVVIVVVWYFVWPRTPTLQYQSAAYDGPKQNTTDNTIVANWKVNFTVLNNDNWIPTNIENFAVTVIDASTGVQFGHGNSGHLMLRPRSIDQVITIPIQINYTSSGPNDNTFQDLYSACVVKVSDPNSTNQSLNIKFRIVYYIAGIVWHTIAIVAPTTNYFQCPNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXE2</accession>
    <name>A0A367JXE2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/potassium exporting P-type ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_010404</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000559">
        <property type="protein sequence ID" value="RCH94606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXE2"/>
    <dbReference type="STRING" id="86630.A0A367JXE2"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140352">
        <property type="term" value="P:export from cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="814"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH94606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="975" mass="107564" checksum="515731F68AD4851A" modified="2018-11-07" version="1">MKRDEVPLQAWHVEAIDDVAKHLDTDLDNGLTSEEASKRHTIYGYNELSADGGPKWIKVLMGQFMDAMNWIFIALAIVCYVLGDYITGSLLLFIAVLNIYLGFSQEYAAEQTLAALRNLSSPMTSVIRDGVEKSIASREIVPGDILLVKEGDSVGADARLVYISNLEVDEALLTGESVPVSKQLIVLEKQDEPLGDRVNMIYSSTIVSKGRGKAIVTATGMHTEIGKVAKKLNDSGDNDRTRLQKSLDKMYLMLLAAAIICVIVVLASVKFKADYDTGMYAMTAALSVLPAGLTTVMTVTLVLGGKEMTRQKAIVRKLKCLETLGSVTNIFSDKTGTLTMAKMVVVRFWTPLEGFFYVTPNGLAPVGDVYQTFEEIPDKIGDDKSAVRVDRDSLSSETLQLVRCAALCNVSSIYRREQDDESEKTTDESADSDDWIASGAPTEVALQVFAHKFGMGKPDLSSNGWELLAEYQFDSTIKRMSTVCVDRNSGVVYVFTKGATERVIELCSNIPIEVDKSRILDTVYTLATKGLRVMAMAYRKLDIPSDITAEELQKMRREDVERDLVFVGLTGIYDPPRDESRQAVREAHQAGISVHMLTGDHEATATAIAKEIDILNRKMSPEETKSLVMTGTAFDALSDEEIDALPKLPLVVARCSPETKVKMIQASARRNNISAMTGDGVNDSPSLRIADVGIAMGKNGSDVAKQASDIILTDDNFATIIRAIAEGRRIYQNMQRFLLYYWICLLGMALVVLVCLAVRDPIGRSAAPLSTLQMIFMYVSITPPAGLLSVLPPSKTVMQEPPRPPTESIFNREIIIDTFVYSIGFCIVCMIAYFVPLYVVGNGIGGVNCDSNYVPGACDSFFRARASLLVTVTFVSMVVMVHCRSYREPQWNLAGLKETFKSLTIIGTFFFNIICLCIFMYIPKVAIEGFRMLGTTWEWGLDVGLVLAMIIYGEVFKLLKRKFMKPLENTLVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXL3</accession>
    <name>A0A367JXL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000582">
        <property type="protein sequence ID" value="RCH94401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXL3"/>
    <dbReference type="STRING" id="86630.A0A367JXL3"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="155" mass="16511" checksum="01ECFBE288BA5B8A" modified="2018-11-07" version="1">MIPSVVLRSPQLVQKVLKSFHAAGGYDALVLPGLKLVDTKDGSVSAEFQVEKKHLNRLESVHGGLLATAVDIGGSLAIASKGLYATGVSTDINISYISGAKLGETITLKARVDKLGKTLAFTTVELYAKDRLVALGRHNKFVALAYKHPENELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXU6</accession>
    <name>A0A367JXU6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_010065</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000545">
        <property type="protein sequence ID" value="RCH94727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXU6"/>
    <dbReference type="STRING" id="86630.A0A367JXU6"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="128"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH94727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="534" mass="60781" checksum="2E3011859CB54834" modified="2018-11-07" version="1">MSNKRARIDDSQIEGKLQKDLFTVESLTRLEKAYKESKPYLHCKIDQLCDNDLLLRVRKEILSSLHFTLKETDIYKVNQTGDLANLDGLPETELKQLSSLFELRNALYSQDFRNFISHVTGCGPLSGSKMDMSINSYQTGCHLLNHDDVIGTRRVSYILYLTDPENPWKPEDGGALELYPVIKKGIPASEPTVTIPPQWNQFVMFTVQPGHSFHSVEEVIGTGNRLSISGWFHIPQEGEIGYKEPSNEGEAKSSLEQLQEDSSDNFTKYPVEEEEKETVGLTEDMLTELAEWINPHYLDLKMIHKLSETFLDESAVQCKKFLNETLLEKLERITQQYDEEDKLATGKDGIAPHGTGVREGWVVQGPPHRSRFMISTGKDELFQYLATKFESEAFRQWLNAIVQIMPVGYRGQIRRFRPGHDYTLATTNTRGQGVLDVTFCHVNKPEFWEDGDIGGYECYMAAHDGEEDPATYKAADEDGELLSLAAGKNELSIVLRDQGVMRFIKYVSAKAPGSRWDAAYEYDLPENFEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYD3</accession>
    <name>A0A367JYD3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000522">
        <property type="protein sequence ID" value="RCH94940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYD3"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="17821" checksum="74A4EAFC8FE8DD8D" modified="2018-11-07" version="1">MQKVYNVGLGNIVGNGLLAGFVGVTAMTIGEKIEQCITGRPSSYVPGHTLERLLGLPRKPDSERFLLNHTMHFGQGMIAGCIRTSMAVYGIQGPISSFIFTFIRLLIDQTLENVTGVGALPWTWPWNEQVIDILHKAVYAFVTGAVSDYLISRNYPHIKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYV6</accession>
    <name>A0A367JYV6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000501">
        <property type="protein sequence ID" value="RCH95098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYV6"/>
    <dbReference type="STRING" id="86630.A0A367JYV6"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15678" checksum="F0286380CF75BC09" modified="2018-11-07" version="1">MSSTIEDNELPKAHVSRILKNALPPGTLLQKDARLAVNKAGTVFINYLSAVSNDVAKAYQKLTIEKKQKKKEKDGSKPKTEEEEEEEELEDTQMEENTPSSPKGQKRTLDDRLEDEDEVMEQKTNEKEQEEMIKEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ36</accession>
    <name>A0A367JZ36_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000495">
        <property type="protein sequence ID" value="RCH95167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ36"/>
    <dbReference type="STRING" id="86630.A0A367JZ36"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38374" checksum="D06598C95B0FD3C5" modified="2018-11-07" version="1">MLVHLKTSSSIILSTALLFILYYVQFKNKEKVIAEIGTSSSDHPCSCPPKINTQFGEHRPVIVPDTMPSIPSSIRDKIQENRLENDDLIITVAGYDMRLDLYNWIEFMKAANEHRFLVFCTDSDLYRHLTIAGYENRAVVVPDDWLWFSNSSSYTPWILERLVHLDINPLMLDIHQLILWPRAREYVSTMMHVRWDTQLIATGRDASHLQGGLIYLMRDSYQVKRLLAQAVQSQMYEPTLSLQEVFHQALSQTHIHVKSGFVLLLDNIHFPNGEVYFEQKRSGTASIEPYMVYVNHKSGKERVDLLKNNSLWHVDEDRVKQIDDQLAAALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZ87</accession>
    <name>A0A367JZ87_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_002678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000479">
        <property type="protein sequence ID" value="RCH95312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZ87"/>
    <dbReference type="STRING" id="86630.A0A367JZ87"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="123" mass="14086" checksum="CD2C61B7F19F1CCF" modified="2018-11-07" version="1" fragment="single">MVFMMTNSAKGFQLNINDMASIQWEFLLSPSPKLHWHRVACTKKEYFGGFHHIDLKEYLLSKQIDTVIVVGMMIHNCINATTYSSTDEGFKLIVVAEAVNTMDQQIFGEMIPAETIWEELLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZL5</accession>
    <name>A0A367JZL5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_002218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000477">
        <property type="protein sequence ID" value="RCH95337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZL5"/>
    <dbReference type="STRING" id="86630.A0A367JZL5"/>
    <dbReference type="OrthoDB" id="3044029at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016570543" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="350" mass="36890" checksum="3637FCF0666C0BE4" modified="2018-11-07" version="1">MVRVLSLICAAVTLLSSTVVAKKADVITQYTVSCKKTYIVKNGDTCSKIDKAFGVSFNQLRRWNPSINSRCTNLYIDQILCLSAPTTHTSQVTVGTPTPTKTKTTTSKTTTTVLTMTNAGPECRTDDDCAGVRCCNLFTNKCVLDPDGTICDIQPTTTIVKTTVSGTKTITTKVTTKNKTPSTPTATATPGLSGLTVQISSSSDFCLFLPPSPGNKDANGGKVDNNAIADSEKTAVAFCTKPNVNAPGAGIFPSGFIKSAKYQTDSAAGFVQVRGTLNITAYQLSSKDDGGQYDNHGSGSPPHSACAGYPYYVSLIEPSSADFCIRCCESYSDCNAGRSAYGCDRVVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K003</accession>
    <name>A0A367K003_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SSO2_3</name>
        <name evidence="10" type="ORF">CU097_014061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000463">
        <property type="protein sequence ID" value="RCH95477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K003"/>
    <dbReference type="STRING" id="86630.A0A367K003"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="253"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="354" mass="40665" checksum="4F3D859FE3B39EF6" modified="2018-11-07" version="1">MASRFTMSRDRLAELRGANSNEKKYDRLSDDDEPVPPMPTGRHDTGYRPPASPSPTYHHGSRGDRHAPESKEQYEMSQRVPSDSALHSTDQFFQAVEEVKELNKKILSNISIIEELHGSALTNITDEQAAENSYRLEKIVKQTTQLNNECKNKIKAIELSNARMPAHSGDLPMRKTQHAALKKKFIETIQRYQDIERTYQQKYRQRVERQIKIVQPNATSDDIDRVLESDEPPQIFAQSLMQANRSGQARAVLSEVQSRHDDIKKIEKTILELHQLFVDMQMMVEQQGETLQQIETHAENTLVDLEQGNKDIDKAIVSAKSTRAKKWMCFVIFIILLIVAGILIWWFAFDHKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0J4</accession>
    <name>A0A367K0J4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000434">
        <property type="protein sequence ID" value="RCH95762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0J4"/>
    <dbReference type="STRING" id="86630.A0A367K0J4"/>
    <dbReference type="OrthoDB" id="2285773at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="378" mass="43633" checksum="5769A6E7896BE6E4" modified="2018-11-07" version="1" fragment="single">MRSFVENRPGMTNVEEWKVIVDKHFDETLESLTSRLDSMMVSSPFSTTIDTVEEKQFCTFTALFDKLIRKDIPLNIKEVIMKKISFSMSGSTDFVVCFSTLIQMLLIQLKNSVLFWKTMKTFFFVKLQGSVWQASFSSLNALHLNAPTLYQLLTQELTKVDQDQSSDQEEKPTSKLVLQIIWLGFAHRVICLPGLKTVRILGTQEKMVNILNEPKKASYKERVLKNPNVILEGQKSKESLSAEIKSLSDVIKQLEGDLKKTLNFQNESDFSRQIHALKNQWGKENNDKLHKDIETLKIARDLSYEKIHQLKDELAQTRQQLYFKQMANRYHVKLTKSKEISLNNRAVRKKNEKGLSNAEARELITPEDFLFADTDNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K154</accession>
    <name>A0A367K154_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane osmosensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SHO1_8</name>
        <name evidence="13" type="ORF">CU097_010580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000448">
        <property type="protein sequence ID" value="RCH95621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K154"/>
    <dbReference type="STRING" id="86630.A0A367K154"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH95621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="277" mass="31189" checksum="818DD17D46045362" modified="2018-11-07" version="1">MEDYNLSLVNPFVATTGALSAVAWLILFIGGCVAQFHGVIWWIIIYELFFVVGYMVVLGLGLLPSYHNMVYLFLAISIVYLTYVCQATLFDVNVSSGNRAAAAGAIILIIMQFLLAFLLTSSEDSWFRSFGTRSMSYGGNLSHRFVNTVRPNRQTRDTGGDMSEKELPRHYNSKNNNNDVSRGDDEEEDIGVSSSPRNRFEPVTALHGYQGSADDPSELSFEKGELLEILDKRGNWWQARKQDGTTGIVPSNYVSYFFYLLYMIFIHFATSFNKATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Y7</accession>
    <name>A0A367K3Y7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000331">
        <property type="protein sequence ID" value="RCH96859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Y7"/>
    <dbReference type="STRING" id="86630.A0A367K3Y7"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000181">
        <property type="entry name" value="CALML5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="170" mass="19791" checksum="256FB86E29DAFC1C" modified="2018-11-07" version="1">MSNRINQQELKSLKEAFNLYDTDHEGAIDVNKFENIVKSLGMIGTDDQRIRELIKENDSNHDGKIDFEEFVNIMNQLVSQSPLASPHETRTNQHYSKRMSRHELDELKMCFDKFDKNGDGQISEEELREVMKGLGEHLTEKEIKDMMNDADTNKDGHIDFEEFKQLMPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3Z5</accession>
    <name>A0A367K3Z5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000326">
        <property type="protein sequence ID" value="RCH96908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3Z5"/>
    <dbReference type="STRING" id="86630.A0A367K3Z5"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10540">
        <property type="entry name" value="SET_SpSet7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="153" mass="17857" checksum="2BEDC233B82D9458" modified="2018-11-07" version="1">MSNEDHVALSQHALNLELRTHPIRGRGVFTKDFIKRNTLVEISPVLFFDAQEYDTHGKYTILDHYTYVWQGGYALALGLGSMFNHDNKPNVGFIRDIPNKLIRYVTLRDIEPEEELCISYGNHLWFETEEDKKEQVSEDEHEPLPFCDDEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K427</accession>
    <name>A0A367K427_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-associated NEDD8-dissociated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CAND1</name>
        <name evidence="8" type="ORF">CU097_005226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000323">
        <property type="protein sequence ID" value="RCH96938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K427"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="7">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="6">
        <location>
            <begin position="1101"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH96938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1293" mass="145262" checksum="F0908380741BD21F" modified="2018-11-07" version="1">MSTTGTNAYIVTNLLEKMNNQDRDFRYMALNDLMNELQKDTFILESSIESKVVKGVLQLLNDKNSEVQNLAVKCLGPLVKQIREEQLFELIDRLDEYTTQTASEELRGIASVSLKTVIAEINQHQGGRVCARIIPKLLRNIQSENATYEMEMDTLDILAEILTRFGTQISLENQAEIQNALLFSLNHQRPAIRKRATVAIGYLVIHTNDSLFHQLVTYLLEGLQSNTQAGDKQRTFVQCAGVLSRYSAVRLGKQLNAFVPIIIACTKKSDDDDELREICLQALESFVYRCPTEASPFVNEIIQLALEYIKYDPNFAGGDDDEDEFEAEDEDMDADEDDEFDDIAGYSDDDDDMSWKVRRSSSKLLCAIIETRLDMLQQMYELVAPVLISRFKEREDTVRIDVLQTFIALLRQTNASEKSGEGYETANKAGSLNLDGISLLPVKCASNDTTETDEIKKTLSFHVPKLCRALAKQAESKSTETRQVCFQLLRELVVVLRGGLETQMELFIPIISSSLSSTLTDQHQMASSSNIKIEALSFLGVFFRKHAPEAIHLYCSKLFSLIMQSFADKYYKITSEAFLVCMEFIKAVRPIYYIPESKQYDIRDIDQDHVPFIKQIYATVLQVLGTSDADQEVKEKSIVCLGVLLVQVGDILQSEQQEAFNVLLERLRNEVTRLISIRTLAVIAQSPIVVGDEFQKCVVTAVDEVTLLLRKNNRSLRIASLECLCVLISRHGECVQEKSLRNLLNEVRPLVSDTDLHLLPLALKTVEAILAKHPESINNVKAYILPTLFQLIQSPLLQGSSLNSLLNLLAALAKASPSDYQYFVKGLVDPLLAAKKSNVQAGSASAVTNKQAASTVAQCVAVLAANTNESNRNETITNFQSYILDPSANESVKYLSLLTLGELGRRINLSEFNNIDQQVIDLFGAQSEEVKFAAAFALGNICVGNIPKYLPMIVSQIKDQPKKRYLLLHALKEIIARYSETSISLKDDADQIWALLLENSQAEQEEGTRTVVAECLGKLALSEPSKFLPQLEENMSSSSVQLRAAVTTAVKYAVVDPSVEYTQYLKPIISKFLQLLEDTDLNVRRLTLLTINSAALRKPYLIRDVLPNLIPLLFQETVVREELIHTVEMGPFKHKVDDGLEIRKAAYECLYTLLSNSLDKIDTHSFLERVTAGLTDQHDIRMLAYLMLIRLSKVAPTTVIQKLDDLVDPLKVTLDFKMRSNAVKQEVEKNQELIRADLRCIYALSPLCDGSVSPRFYQFINEVKTGPLATEFRSIADEAESREYRVSDYMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5A2</accession>
    <name>A0A367K5A2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COG4_2</name>
        <name evidence="11" type="ORF">CU097_014705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000286">
        <property type="protein sequence ID" value="RCH97335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5A2"/>
    <dbReference type="STRING" id="86630.A0A367K5A2"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="179"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH97335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="783" mass="90160" checksum="888823082F6BF711" modified="2018-11-07" version="1">MPTATLPNQSLMQTNILDKDFDSLINIDEIRESLRQLDEEENRIDAFLDDILKQESILDTSLNSLKAITPQLDTLKVKAAAFTDTVSQTAHLAEMISDKVRQLDKEQTRAKLAIKYVEDVQELKFCISSLNEAMQKKEYDRAALLLQRASKIDSSILKGSLAEFTVPTSEYPDHPERTLAETKATLFDIFSRRFDDAVAERNQADITRYFKLFPLINCQTEGLDQYSRFVCNIIKSRCADEMSEGLVTAPTYFADALTRLFENIAVIIDQHQPLVEMHYGKGKMLRVIQRLQEESDKQGVAILDRFLQTRKLETKLVEIQCLMIAMLRNGSTIPNRASPNPSTSTSTQNDDGNNPLVDPRQLDANLYELSLISQRTVLFNSFMSERASDEMDVLASDEKELVMKGKDSRFYGPNGLLVSSGLSKRVHEMMNSYLVIDEYLLKKSITKAIHLDDYDPTTPHASSTCVDDVFFILKTILKRCISTYKPDVISSTVRTLLKALENQYIHYFQQHMSTVFTAHDTTGRNAEKAIENAKISYMVVLNNLDISADYTHRLAKELQPEITRSIWLDEENDVARVTASIDKFEGIADKFNQLLKHGIEQLVNQVLKPRIRPLFQESYREVKYVLEEDEYNEADIEEKFVKRFRQGFNHLIHLYKHTLTENNFNTLMDLMLDIITAQWERIVSQTRFNQYGALRFDKDLRSIILYLSSITEWLSRDKFTRLNQMSTILNFEEVTPSEIHELWGNSSSPINWRLTVNEVKKMLGLRLDFESKLADEQLLLNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5J4</accession>
    <name>A0A367K5J4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000273">
        <property type="protein sequence ID" value="RCH97493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5J4"/>
    <dbReference type="OrthoDB" id="2290844at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="32489" checksum="F0C4394095E1DC96" modified="2018-11-07" version="1">MSFSLLRRSFHSIRPLYQEAWTKTSLKKLKKNELLQLAKQHHVQKVMGTKNDIIDQLLSLQEKKNNQDEFDKDWVSAFESKVAHRIHKKQVAADEPKPSSKPHPLNDNIFRTKPVTATSEEEETVDQPVIDEFKHIDEKSNHGNNHESSQDEIDQKWVEAFELKVNTRTSKRREQRAEPVINRSIDIESTLEDDIKDVVQNEQDSKKETAKNDQVKDTVQNVENKAKDTVQNVENKAKDTVQNVENKTNNTLISSMIGTSLLVWYIGGQEGFIKIWEFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5M7</accession>
    <name>A0A367K5M7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ABCB8</name>
        <name evidence="20" type="ORF">CU097_012491</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000303">
        <property type="protein sequence ID" value="RCH97151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5M7"/>
    <dbReference type="STRING" id="86630.A0A367K5M7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000215">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="19">
        <location>
            <begin position="144"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="463"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH97151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="694" mass="75933" checksum="AAD09288BB6CDF76" modified="2018-11-07" version="1">MPLLVARFAVRPCTHAAKFGYRSLSSKASISSVIAKHVSRNHFFDTSFSSSQEPGTILSILSRTAASVKSRGPSLVSLAIGLRFAHTNKISIAYCEAQPPTFVKSPLVQTKTVHDTLLQKKQNTRSVLYDVWELIKPDLGLLCLIILSAIGAAIVQLQTPMVTGQLINILSSVKELGSLTIRDLNKPAMKLFGLLVSQGFLTFAHIALVSAFGENVAKRLRSKLFSAIIQQDLTFFDTHRSGELVSRLTADVAEFKSTFKQLVTQGLKSVTQTIGSAIQLFRISTSLTLTMLGTMPILYIMLNLYGSYLRNLSKKNKQLDGYAGGVAGEVLSNMRTVRAFASEEREMEHYGKSCNQVATANQYMGLHIGLFQGLTNISIGCMVLTVLYYGGSLVVKNELTGGDLMSYMLSTQTAQQSLVSLGVLFGQSIKAAASASRVFEFIHLQPQVPLRGGLIPDHVHGNIQFRDIDFSYPSRPQHKVLNGFSLDIPQGTTVALCGPSGSGKSTIASLLERFYEPTAGNVYLDGEELRTLDPSWLREHIGFINQEPVLFATSILENIRYGRPDATLEEVKEAARQANAESFIESFPDGYETIVGERGAALSGGQKQRIAIARAILKDPKVLILDEATSALDTQSERMVQEALDKLMRGRTVLIIAHRLSTIRKADTIVVMGKVPGNILEKGKLIVCTNDFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K715</accession>
    <name>A0A367K715_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000237">
        <property type="protein sequence ID" value="RCH97929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K715"/>
    <dbReference type="OrthoDB" id="2261101at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="58" mass="6676" checksum="7AAB17451DF693F6" modified="2018-11-07" version="1">MSDKREPLKIELRNYQPTDEERQVMRSAMFRFITPMLLGAAALGYSTAENQENGDILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K725</accession>
    <name>A0A367K725_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000230">
        <property type="protein sequence ID" value="RCH98024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K725"/>
    <dbReference type="OrthoDB" id="2266783at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22450" checksum="F51AC76B9A06A765" modified="2018-11-07" version="1">MTYPGTPVAKILQKSFKKTTWQELVIMYKRVELLVSEGIYGHISGGGFKSFLGANIKLTKLIDTETPGKIYLLQSMLSAVFCEERLLQNYARPAANYKWGFRSTRFSAKGFKTVNPLYTGNNSMEQAASLMFRLLAYNRFTVEDQERAVPSIHEAAAGYSIDIFRVADDLGFLRMLQRKKKVPFIHRVTWTSTERAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8A1</accession>
    <name>A0A367K8A1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="11">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MTD1</name>
        <name evidence="15" type="ORF">CU097_014229</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="11"/>
    <dbReference type="EMBL" id="PJQL01000200">
        <property type="protein sequence ID" value="RCH98397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8A1"/>
    <dbReference type="STRING" id="86630.A0A367K8A1"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="13">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="14">
        <location>
            <begin position="141"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH98397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="311" mass="34789" checksum="5651B8A20E1233D4" modified="2018-11-07" version="1">MSCKTVLASKVSASFRDQIKKDIKERDIHPKLVGFLANEDPAAMKYAEWTAKTCAETGVDFELRKVSKLELEEKITEANEDASVNGIMVYYPVFGGKQDLYLQSCVSELKDVEGLCHKFVHNVYHNIRYMDKEETMKCIIPCTPLAIVKILEFIGAYNPVIPYGNRLYGRTIAVINRSEIVGRPLAAMLANDGAKVYSVDINGIQLFTRGTGIHLKAHKVEDTDATLEQVIPQCDVVITGVPTPKYKLPTSLLKDGVIAINFSSFANFEDDVKTRASIFVPSVGKVTVAMLERNLLRLYDYQNNLTEKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8L9</accession>
    <name>A0A367K8L9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_001760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000191">
        <property type="protein sequence ID" value="RCH98516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8L9"/>
    <dbReference type="STRING" id="86630.A0A367K8L9"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="413" mass="47522" checksum="591F10C839CDD7C8" modified="2018-11-07" version="1">MNDGRSPSLISLGINTQTIFSGSSVSSNSPLNSPLLSPAGSPFPMDPSWDQLQSQFSQQMSLHPPPPPLSTTVPITNKSGSNNTFVHKLYNMVVDKQYQHLIAWTYTGTSFIVCNITEFSREVLPKHFKHNNFSSFVRQLNMYGFHKVNKSPRGHRTLAENQIWEFSHAKFIRNRPDLLDEIKRKALETDSNKKDPGDINSHMALMQMSQSDMMQQISQLQDGLNQVIHELEETKKKQNLQQQVMKDIMDVMTRQYGTTFNLPLDGSSVELKQDPERPPPPIYITTPEQQDQNLYLNINQHRLSIQRSPSPSPTFTSSIQSPLPPSPCTPHFLSDDEANSIYSPRSPLSYNAHLIEQPQPQQQQQQQQQQQQQLHQQQQQQLQQLQQLHHRQELEQLQLQQQQQQQSYHTFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K909</accession>
    <name>A0A367K909_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_014652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000177">
        <property type="protein sequence ID" value="RCH98704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K909"/>
    <dbReference type="STRING" id="86630.A0A367K909"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="288"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="860" mass="100026" checksum="794AA1D4DC72AD1A" modified="2018-11-07" version="1">MTNKRDFSASFPADEDEDDLIRQSLEFEQDEQEIIRFDDYMNRKEEHHIEPDPFETNPSTFQNSLIDAMDYMDIEDDEPLFALHDEGLSRTTNTAKITLETTEQTDYTKVPLNGSFVTATCPRTGVSLYFPKQVEGFNKNRKNDLYKEIISKTNKKSLLSTPIIRLMQNIEKANQEQLEKIERDIQIDKRQKKKKKKIEKDNSGQLWVDKYRPKTYSDLTGDQRLFREVLRWVKQWDFCVFGKQPPQETQRDKVMRELRDTLNSNSNNNRYYKRDRIQKSNDSLKRPEKKILLLSGPPGFGKTTLAHVIARLAGYNIIEVNASDDRTGDVVKTKIKSALEMQAIIRDSNTEEDGKRTMAMNQKPNLLVIDEIDGVSSSSGSSGTDSFIQQLVQLASVELEEDKKKRTKSKPLLRPIICICNDAYTPALRPLRAIAHSIQFRKVPMMTIAKRLEYICENEGLETDQRTLCMLAEITDGDIRSCLNTLQFIRSKSRVFKREMLNEVGLGKKDMTQSLFSVWESLFCKPSSNQKSSVQTEKDGRYLSRLTESIASNGEIERIMQGCFESYPLMRFHDVAMQKVVRISEWLDFYDQLNQRTSERQEFELYKYLPYPLVNFYRFFAGTTMQEHRVEYPRVDYQVFLAKKQFENLIEIFLSGVDATKRRYLNKTIISKEFVPRLMHVISPDLRPVNKQLIKPEEKKVLARLVDIMIEYGLSFIQERTEDGQFLYKLEPPVEQLLQFELSSPKAILPRQYAVRQMIAQEIETEILKRKENMLALRGGVKKAPIDESPVIKKVQNKPEKVAVDFFGRPIVKQKQKQKQSSNKMDVDDSQDTAKPAVSYKYHEGFSNAVRKPMTVQMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K916</accession>
    <name>A0A367K916_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_013549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000180">
        <property type="protein sequence ID" value="RCH98656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K916"/>
    <dbReference type="STRING" id="86630.A0A367K916"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="271"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="572" mass="63689" checksum="643BE19697942EC5" modified="2018-11-07" version="1">MTIDNKEPSKSLLARSGYLNEGTAMDPKKRQELGLNGLLPAKIETLDIQKKRCLHVLRSKSSMLEKYILLAQLRTSNVRLFYKIVMDELEELAPIIYTPTVGTACLEYSTIYPFLAAPGVPDGLYLTKADFPTLIQTIKNYKSEFDPQIAVISDGSRILGLGDLGSNGIGIPIGKLQLYVAGAGIDPRRTLPIILDLGTNNEKLLNDEFYIGLKQKRPDDEEFYETVDTVIQALYTVYPNLLLQFEDWSSEHAFGLLEKYKNKILCFNDDIQGTGAVILSGIINAIRKVQAEDSVSPNSHRIVFYGAGSAAIGVARQIQDYFQFEHGLSEEEARNLFWIVDSKGLVTKSRGDKLAQHKVYYAREDNDGQEYKQLIDIVNYVKPTILIGLSSTAGAFNEQVLHRMGELNQQPIIFPLSNPATQAECTFEQAMEATEYRVIFASGTAFPAYTIPSTGEIRYPGQGNNMYIFPGLGLGAILSRPRHITDRMIYAAAKSLAESLTVEERQQGWLYPSLKRIRAVSCSVATAVCQEAINENLATVSMINIEDYVTSHMWSPTNDPYGTLYSEIHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9Q6</accession>
    <name>A0A367K9Q6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000165">
        <property type="protein sequence ID" value="RCH98859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9Q6"/>
    <dbReference type="STRING" id="86630.A0A367K9Q6"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53258" checksum="BC149617CA8C243B" modified="2018-11-07" version="1">MLLTRIVNKPQSAHGLIRFTKSKAFILFILASFFLLSHIIIHFRLKLHYSSATATVIGTTIKTNQFQQERYLAYLPHSGLSNQRIELANALLLAYMLKRTLLIPPAFLGNVFGWMPREQLMDHLQWLTTPKPFTKLCQRPTPGKIATYVQRSRCEEYRNFGVLSWSDLHDLSPLSPYIQYRFQDVMSLETIQKQLNLSRDDIYLYEDAQLYDWRLYENTTQAIEILNEHSNYVDSFGGRRYYKVLLPQHFYREEKLLFLGGVFGSTRLNIVDPELKTVYQKITRALHYRLDTPLGMTVQSIVDHLGGKGSFMSVHFRTGDKPFKKELPTNLQNFVKNMTEIVGSHETDSCVDIPLDSDQITVGKKVKVYIATDHKDPKGKSSDLLPWFREFPCTVTLGDLPGHLLSPLDDLRDMVSPSKSLKRFLIPLVDAMVAAHGRDILTTPRSTFSKYIEELHKAWVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA23</accession>
    <name>A0A367KA23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Potassium channel, sub T, member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KCNT1</name>
        <name evidence="17" type="ORF">CU097_011810</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000151">
        <property type="protein sequence ID" value="RCH99038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA23"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005228">
        <property type="term" value="F:intracellular sodium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="348"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="16">
        <location>
            <begin position="439"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="14">
        <location>
            <begin position="574"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="16">
        <location>
            <begin position="875"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="718"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH99038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1168" mass="132734" checksum="7ED37A350F4030F8" modified="2018-11-07" version="1">MGSNFMVLKEIEARDNEESSLISDSHHSTYGSTQGQRSRLSAPSLNQLPDDPYSDHGGSSEEFSSAKLAKRKKKRLQKHHKNRPKLVSKLSHIVRSAAQSEEEDNTDDVIQISPDDLILPELDQNAAEVREYVSSPIKPSDRRISRKHKVNLSTIREKYREARLHERNGTLPHTRLQSIKRYLHYDARIANAKEILFGNTSIILFVYTDLLVDILLCLAYLVEMKEEASITAEPYWLFKWRSYDLWSLCIILSLWNFASFVMRMILTGKPLSVLFSFRSFIEALTTFPFLMSVFIKHGQFLYVPYFLRSWVLLLRIKSVIKIKTNLLMTGKPVDPLNSKLVHLAGTIMVLLYNGLSAFQYCEVTFGSNNYSILDSLYVVMVTLSTVGYGDITPQTEGSRVVMMLLIVISLAVLPSLIADALNTLRKRNDWGGYVSESSKPFILLVGSFRPEQVTEILDGFLNTENTEPHLNVVFLDINRPNEELKYLERNSMWGHRIQFIHGSVLDEQTLKRVQARSASAIFTLSDQHAPDPQKEDERNTVRLWSLYCHTVVHNVDIYTYNLSPSTAIYQKMAKEIICVREFKQYLLAMNCRCRGASTLLTNLLHQRRPMDHYDESWQAQYDDGSCNEIYMDRPPLALVGLSFKEAAWVVYTECQVILFGIKTYLDSPDHREMLLNPENNYIIKSDDLCVYMCESPREVEDINALHINYVREKIAKMTTTRRTDSNKRNPSSETVMYVPSSGASIKNEPRASLPPASESAPTTPGTINEEATMTMSHISRPGSPTMQGNSRTLHHVPSIESNRTISPIRQSFQLSKLPTPRMALLTGSRRLVSRLGQLPTLEHPDTDIEASPVCYLLDKPATLRELTIESAEHLAGHIVVCMHHKVSNIFKFIFNLRSPQLKSNELQDIVFLCTSLPTPKTFESLSRFPKVFFMVGDCQHPEDLIKAGVKRAKQVVVMSERECLDQHQRTSDSPAIMTSHLLDLLLQDRPYDSSRIVNLVEKSNIRFMHLLQGKDVAEEIDVFYTPAYAAGNVVVDSLLSNVLLSQTYYKPDIVSVIKALCGMPGPLYDKDTAHMLMCGTKFHSHLFKSSRHLMLVVLPPLFIGKPFSVLFESLILDHEVVALGLLRAPDENMGNELSFVYTNPVPSLILKRTDKVYVLASPGWSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAJ2</accession>
    <name>A0A367KAJ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_015096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000137">
        <property type="protein sequence ID" value="RCH99234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAJ2"/>
    <dbReference type="STRING" id="86630.A0A367KAJ2"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="781"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="615"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH99234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="923" mass="92660" checksum="419ED623F9391217" modified="2018-11-07" version="1">MFGKSTFGTSTGGFGQPQQTSNVFGQQPQQPQQPSAFGGFGATSTPNAFGAATTGSAFGQPAQQQQQQPAFGTTAPSTGFGAGTSAFGQPKPTGFGGFGSTSTPAFGSTQPATTGFGGFGSTPASNTSAFGSTSTSTGGFFGQRPATGGFGSTPTTTAFGQPQQPQQQQTSAFGGFGTGGTAFNQPATGANQGTAIADFTATQDRDITTGVNNFFQTITAMPQYKDYSLEELRLQDYAQGRKTASAAGGAFGQPAAGGAFGQTTSTMGGGAFGQPSTGGAFGQPAASTGFGQPAQSNMFGATSNTGSIFGQQQQQQPTTAFGQSTGTNAFGSTTNAFGATGTNTTGFGAGTTGSAFGANAAKPFGFGGTSTAPTTGFGATTTGFGQQGTTGGFGQQNTTGGFGQQASQTGGFGGFGAKPATTTTGTTGFGGFGNTGATTSGFGAATSKPATGFSFGQPATSTGTTGFGGFGTSTTPSLGGFGQTGAGTTTSAFGGNKPATSTSFFGNTTGATTGTTGFGGFGTGQTNTTGGFGTGTTGGLLGQKPAGTLGGSFTSGGLGGTGFGSFGQQQQTGAFNLPSQGGLTTFATTGPQNGVQQQPLIATVDKNPYGNNPLFDLSKLSGSNAENNRSGPSAVAVSGSTSKPSTPHFPVSPRVVSKIKLRGFSTAAARPTRKTMGNSSLEGISDDAVLGTGAFAPRDNNKKLVFDNDVDAASIVALVNKKGEKKKAVFDPNLEYVASKEIHKDTTSTAPLSSASLDSIHPGTSNNNITPASTSSALAIKNGYYVSPTLDTLKGMSKESLKSVQNLVVGRTGFGEIRFEKPVDLSQVDLDDFLGNLIVIDDRRVVVYPDEATKKPAGTELNVPAVISIENCFSHDKYTGAPIKDPEHPRFKLFVDKIRQRPGVEFVSYDNSTGTWSFRAQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB27</accession>
    <name>A0A367KB27_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PRP4</name>
        <name evidence="25" type="ORF">CU097_015508</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="21">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000125">
        <property type="protein sequence ID" value="RCH99424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB27"/>
    <dbReference type="STRING" id="86630.A0A367KB27"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000123">
        <property type="entry name" value="serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="25" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="400"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="208"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RCH99424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="720" mass="83461" checksum="23232F9E0480783B" modified="2018-11-07" version="1">MAPAEHTDVEEGEINAYLEASNRKRSNDAHYERHYKKSRGEDPFAEYERLARRHSPKRHHSRSPSPRRRHSRDYESKYSRRSPSRHASREDRYRYERSRYENRGRDEKRRDDHHREDRRRHDHSPEPKRREEYRKESRAQQLKEEIQKKDVKKDQTTTESLKKQVNEEKEEEGIPPNIEIKDEEEKQKEEDRLIEERRKRRLAILNKYKETSTPEASTSSPIQPATPDNNVNNVSDVGITTTTTVEAKPDDNHTTTTLVETKPDEQTVDNTESPNDMSAADYDPSMDHIRDLHHTSSEADLLKMKDHQEKITEGVDSQADMLASDYTEKLEKPSVNNQMTEIDMFSDNLDMFTATTHIKTGQNALLSNVAAAANPSLTDNWDDAEGYYSTRIGEVLDGRYRVLTNLGRGVYSSVVRAKDEKTNEEVAIKLIRSNETMYKSGQKEVTFLKKLMEADPDNKKHVIRLKRHFEHRNHLCLVFETLSMNLRDVLKKYGKNVGINIKAVRVYAQQLFLSLSLLQKCRIIHADIKPDNILVSESRNTLKLCDLGSASDVTDNGITPYLVSRFYRAPEIMLGLTYDYGIDVWSVGCTLYELFTGKILFPGRNNNQMLKHIMELKGRFPNKLLRKAQFASNHFDEDYSFLSHEIDKVSKNEMVKKMTFIKPTRDLKSRIMAASTTNSDEENRLVQAFIDLLDKCLALSPDKRLTPKEALSHPFITGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB34</accession>
    <name>A0A367KB34_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000129">
        <property type="protein sequence ID" value="RCH99350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB34"/>
    <dbReference type="STRING" id="86630.A0A367KB34"/>
    <dbReference type="OrthoDB" id="2213591at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF958">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WNK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="46008" checksum="9E68B2DF7AF580B3" modified="2018-11-07" version="1">MIDVSDYIRTHPSEFLNPIHKGHYSTICWSDVLRLDRSMFMKGWRPRDEQYATLYDELLHHYFNDPLKLQKVLEQCDQPLLWFPYTWFRSIKALPSGIRGQVYLAHCRLPWKCCKINMAIRAVNDITQQCLKHAVGITAIPSKYKKDYLIGLVSIAADASLEQLIPQVDQWSFHKIYRTAFMTASVVRDLHKIDKVHPNLQPKNILIKGTQFSLVDTQPLDKTFYGRYPYFAPEMRVDQASNVYALGIILWQLVSGVIFPTSVAVCPEVYKMEPLKTVDASYQAIFTQCLAKDPRLRPTAQQVCDSLIALLLQHTSISRHLWEHGEEVRQRQARIVKYLLHCHQNVAVPAMNDLMQGASLKKRMMLRITASVGSYYDQKSNCGILDLPEIGMENVYLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBG2</accession>
    <name>A0A367KBG2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000115">
        <property type="protein sequence ID" value="RCH99555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBG2"/>
    <dbReference type="STRING" id="86630.A0A367KBG2"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54565" checksum="D987EA9953103F30" modified="2018-11-07" version="1">MSQHPLDNCTYSTPQGSVDSLPPLTDDDLSGFVRKLSSPHPKDDKIIRAASPHGRRYLKPINGIQTKGFARSALRRSSVLTLGSIERLQNFYAKRELKVNKGGTLGFQKTLTEEPDDFDEQLPTPKAPPPSWIDLDVETDLDVLLNICFDDIQNTLTTWSMVVGPRQSSSSSTSSHPLSSDSADDSSRAATPTEGNFQILPLIQSVTKMLDSVRNYTVHRHDLSDSALAKLRQASLALLEAMKDLENQYREEGNDEEGYLYKASEFNLLERERQAIHNYLRAVETYAFNPPHHIGSPPAVFTPEIQALMGRTSILSLSDDELNENNTKKIANSIPVWLERGSFPNDSLGRYHALLVDSQATNDSNEEISIPDPKEDEDAFLECLADGRALCIAYNNIVKRSKRPFGFINKIHSDTRRTYRAVENLRFFTAACKFRFELTFDEFDPSEIARKTDKGLVMIKNIVAAFCDCVICELREQVDMIQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDY4</accession>
    <name>A0A367KDY4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000067">
        <property type="protein sequence ID" value="RCI00320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDY4"/>
    <dbReference type="OrthoDB" id="2272099at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="13930" checksum="3DD4336104A29352" modified="2018-11-07" version="1">MYLCPSYTNYFESLDLLKSHANTIHEKDDCPEATQSDDQSEPDLDEEELGPEIHLPSDNTMSIISSSIKPCAAVNHSVPSTDAVASICGDDADSAALHDCQQMYVNDTEKSETLYISSTKDYRCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEY2</accession>
    <name>A0A367KEY2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000040">
        <property type="protein sequence ID" value="RCI00784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEY2"/>
    <dbReference type="STRING" id="86630.A0A367KEY2"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="324" mass="36914" checksum="22EE3C384DE3B35C" modified="2018-11-07" version="1">MGSCLSILYKTKSINRRKIKDRNILSNTMAGHQDQTLVANNLTNLNTKREFHNKKQTTYWLPKDDEEQRRLTGQHFAIKNLYEGNVLPSITEALDFEKGINILDAGCGSAAWIMDMVQEYPNCTYHGCDIDDNTYKNIDVKQFIFSIGDITQRLPYEDSTFDFVHMRFFIAALREEDEWPAAINEAIRVTKPGGMIQMTEFNLQLPADPSNLFYKTMSACIDLSKSKGQNPHIGAELEKMLSRYSNIKIVQSDSRSCDMSSGTLTAKMFIWDCLEGIKGVQPVIGPKLGINTMDELDDFIVKYKHDLETKESTFYLNSVAVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEY7</accession>
    <name>A0A367KEY7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bud site selection protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BUD6_3</name>
        <name evidence="5" type="ORF">CU097_015692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000039">
        <property type="protein sequence ID" value="RCI00813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEY7"/>
    <dbReference type="STRING" id="86630.A0A367KEY7"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="346"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="827" mass="94335" checksum="9A5BADA9A0D1B267" modified="2018-11-07" version="1">MKRTSSTSSGMSGEIEQVVTKLLRTTKALLEALTQWSNMRASNAEIFEIHDTLEKQFFLVSQAFEEAGVSMNDLQWIPRQLRESVSIAMMEQPSPAALDQYLPRIREVIVHLLHGLKGKQAQLREKDRESRASVRSSSNSDAWNREVPLAALNRGSSTSSNGSQRMMMYPNNSPPLPPMSSPRMNGTEYDTWSGGMPRPSVPTNDLSARIMPKRPYSPPPPPHGSPLVPLPTRSTSSSRQHIPNPPPPPPAPPSNNVNNQPQTFDENDPNTASALAALKRQENLARRSSVRRASMYRGNSDYYSSISSRMQDTPPVPALPKSQLARTVPEEPEESHEEEEKGLTLFLQIGKQVKKTVYQGEISIPALNMLFVEKFNYTSRQNDFPNIYIRDPSIGVSYELTDISEVKDKSVLSLNIDEQEEQKESHKEWVLKLSAAFEEQLKGVTQSFTQQIEQVKKQLESSNEALIEQITNQILAEKNNRQEEEPAKEEEKKKEEQEEEKKEELPAQKMYDQGQVKKQLIEIESLKRDLAVIRQLDRERKEETSQIIQEIRAKAASLTKANEQDIKVISARSALEEGKKGLLEKSDKITTRLEELQDTIDQLKLDVTQRKCRPSEIQMTHCAKERRELSKDIEEFGTFIAQVKPKWKKTWEHELQTIVKEQQTLKDQEYLLTDIKDDLEALSEVFEQLEKIYAYQVSAKPVVREFRVVPAEDGHEGMSSVLKQVATIDVDHERRLRAMEQADKMRQRELANRIDDFEKELITFVDTKKLKKTGGALEIDRLRKQKDEEILKQMYASKAAGNNTNNNNQEQPPETEPETEQVEASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFW7</accession>
    <name>A0A367KFW7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_015084</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000044">
        <property type="protein sequence ID" value="RCI00722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFW7"/>
    <dbReference type="STRING" id="86630.A0A367KFW7"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016976564" description="rhizopuspepsin" evidence="13">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="84"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI00722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="394" mass="41227" checksum="DD66BB66498C0844" modified="2018-11-07" version="1">MKFTLISSCITLAFVALAVEAAPGGKKINVPLTKNENYKPSAKKSLQKAIAKYTKHKLSTQSPGVSPESGGAVPVTDSGNDVEYYGIVKVGTPGVELRLDFDTGSSDLWFASTLCSDCGSSQTRYNPSKSSTYQKDGRPWSIQYGDGSTSSGILGIDTVELGGLTIKKQTIELAKTESDTFASGEIDGLLGLAFDSITTVQGVKTPVDNLISQGLISSPIFGVFLGKASNGGGGEYIFGGYDSSKIKGELTTIPIDNSQGFWGITVDGSSVGGQSVTDSFSAILDTGTTLLVFPNDVASQIAEAYNAQDNGDGTYTIDCDTSNLQPLTFSIGGAEFEVPSDSIIFEQDGGNCIAGFSYGDLGGLSILGDVFLKNNYVIFNQEVPEVKIAPSINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG06</accession>
    <name>A0A367KG06_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_015761</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000025">
        <property type="protein sequence ID" value="RCI01109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG06"/>
    <dbReference type="STRING" id="86630.A0A367KG06"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016711358" description="rhizopuspepsin" evidence="14">
        <location>
            <begin position="22"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="85"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI01109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="395" mass="41366" checksum="49172CB3B6C34FE8" modified="2018-11-07" version="1">MKFTLISSCVALAFMAFAVEAAPGGKKISIPLEKNQDYKPNAKNSLKKALAKYAKHKISTQSSGDSPNGSGGTVPVTDDGNDVEYYGIVKVGTPPVELKLDFDTGSSDLWFASTLCSSCGSSQTLYDPSKSSTYQKDGRPWSIQYGDGSTSSGVLGTDTVELGGFSIKKQTIELAKEESDTFASGPIDGLLGLGFDSITTVKGVKTPVDNLISQGLISSPIFGVHLGKASKGGGGEYIFGGYDQSKIKGSLTKVPIDNSQGFWGITVDSTKVGDKSATDSFNAILDTGTTLLVLDTQVASKIAEAYNAKDNGDGTYSVDCDTSKLQPLTFSIGGAEFEVPTDSIIFEKDNGNCIAGFSSGDLGGLSILGDVFLKNNYVVFNQQVPEVQIAPSVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH69</accession>
    <name>A0A367KH69_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_015668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01000004">
        <property type="protein sequence ID" value="RCI01575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH69"/>
    <dbReference type="STRING" id="86630.A0A367KH69"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI01575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="269" mass="31320" checksum="061BD9E3BC2EB7DA" modified="2018-11-07" version="1">MVDTQEETPKCPVDHNAYKHFIPQENQQAEEGAKCPVDHNAYKHFTPQREGSVKEPDSCPVDHSARQNFIPASKEGCDSDAIDSSNYMPKVSEQTPQHDQRLPLGKERQISSIPRANSSEKMWIYPSEQMFFNAMRRKNWTPKEEDMSVVVPIHNAVNEMAWQKILEWEKMHETECNQPMLLKFQGRPKDITPKARIRSWFGYSLPFDRHDWTVDRCGEKVTYIIDFYTGKKDPKNPISLSFYLDVRPAPTPAGIWDRIKMSFRKGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJ94</accession>
    <name>A0A367IJ94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005688">
        <property type="protein sequence ID" value="RCH77754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJ94"/>
    <dbReference type="OrthoDB" id="2203053at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="151" mass="17538" checksum="06353C84AABB99AA" modified="2018-11-07" version="1" fragment="single">HTRPIMDALENTDDLFALLFESITYGSDQEPHPNVHKEFMIQVYDQYRDVVKQIIDLKTLKEQITTRFIWHVNEWSHQNLNHPNQDPASIHLYLNTKYNHLKTLLPRYASYRALNKKVKAGDPWVQATQTRDGLSLGGGICNESGVETDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJF9</accession>
    <name>A0A367IJF9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005639">
        <property type="protein sequence ID" value="RCH77812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJF9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="155" mass="17156" checksum="D0989FED2C66C13E" modified="2018-11-07" version="1" fragment="single">MSPGIQHHSTPSQSRPASHTSLRPVISETDNVSEVNSASSHVSVTTTATTTLAPPPPVPPKPTVIRTDRVYEDYQQKSPWQFASNNSSNSNQLHTSNIGQSPVISRPSHFYTTPRTAPYSPGHENPSYSQQMPIAQQPYVQAYFHPQLQQHMNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKU2</accession>
    <name>A0A367IKU2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005270">
        <property type="protein sequence ID" value="RCH78302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKU2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8959" checksum="0F9E424026656ED0" modified="2018-11-07" version="1" fragment="single">ACHDEELVQGFDFILGDLLPYGRNSQKLRRKMMHHHRLCYLTSMIHKFSWYNWCEARHELVRQVKAPNALDVSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILJ7</accession>
    <name>A0A367ILJ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005074">
        <property type="protein sequence ID" value="RCH78550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILJ7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="14638" checksum="5BD486B45FF33F9B" modified="2018-11-07" version="1" fragment="single">TKKSYSVRTYAVLVSIPSKVNTSPRGSSLYQSFDPLNTASQADLSIHRRGITDHSVFYRTSHQLKRLKAPFSIALSERFLFDVRFGITTHDDVQGTAIEVKLILSTAAEIIFISSDCLTADANTQIDKIMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMI8</accession>
    <name>A0A367IMI8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_000670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01004832">
        <property type="protein sequence ID" value="RCH78902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMI8"/>
    <dbReference type="STRING" id="86630.A0A367IMI8"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH78902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="34026" checksum="725A5ABCDA26671B" modified="2018-11-07" version="1" fragment="single">REQNKELQVSSVKVLGECDGTYPLQKKRHSTEFLRSIGHLRMRGNTGSAVLRVRNAAGEGLHSFFRDQEFILTNTPILTAHDCEGAGEVFKVHGSEKFFKRPVYLTVSGQLQAETTASAMSRVYTFGPTFRAEESMTSRHLAEFWMLEAEMAFIDQLDTLLDVAEASIQESTRYVLENCSEDIAFFNQWIDKSLLERLQKSIDKPFVRMSYTEAIEVLQKHQDKFTYPTTWGSSLQSEHEKYLASEYCQQPVFITDYPAEQKPFYMRANDDGKTVGCFDLLVPGIGELIGGSLREERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IML1</accession>
    <name>A0A367IML1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="1">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01004821">
        <property type="protein sequence ID" value="RCH78920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IML1"/>
    <dbReference type="STRING" id="86630.A0A367IML1"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi-associated nuclease 1-like winged-helix" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH78920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="259" mass="30483" checksum="97FAAE06F172A611" modified="2018-11-07" version="1" fragment="single">FDDMVQTVLDGEDYLLDEKELDLCCRFVGLKDDPKHLLVRLLMRRHKWIKQDTLDYPLTDTNKAIQELNEIGFIESDLKDIETALHVLTKPELKNIAKERHIDMQETRKNGYIKEIVKYALSDHISYGNSQTIHESKMKKLWDTVNKYLGPCLRVRSEVYDLFQRLQIVYYRITSLHDTNYITSSILAKINRRSYPQYTWSRSNSIWPCRADLLKFEEALLIEKEFETMVKDIPRTRTAGQKDNGEDVQALLASCWSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQW5</accession>
    <name>A0A367IQW5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004231">
        <property type="protein sequence ID" value="RCH79881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQW5"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="305" mass="34707" checksum="E3F5695CE832433C" modified="2018-11-07" version="1" fragment="single">PEEEDIIDDTFDLPPYQIHSSHSKHSMTPYIGSIQVRNSSIYTGTDDYSSSSAQSDIIENYHDAVEPNLVLLDRPVVEPQNDSTVDLMFQKKLNQTNVDFPKTDSENKRKDDVEISDTASIKSHNFGDKNFAFKWINESFEEVALSHPSLDRMIGLVVSPQTRILLRAVVKMINAFGQGFKITILQLISSLSLLQNFYAEIPREPPAEKITDLKFLDEAYYFLGHAIIAYGWRGISYLGDYAKYLKDVMKTKSNKEAIVRYLKIPPEDLLGYEYGLRKGAVFQPSYFVSYDQAHEAVVLGIRGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISN3</accession>
    <name>A0A367ISN3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HTS1_1</name>
        <name evidence="16" type="ORF">CU097_002296</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01003778">
        <property type="protein sequence ID" value="RCH80705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISN3"/>
    <dbReference type="STRING" id="86630.A0A367ISN3"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00939">
        <property type="entry name" value="MetRS_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="15">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="75"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH80705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="60935" checksum="5D4E3177077438AD" modified="2018-11-07" version="1">MSDTQQQKKLELTQSIESQGQKVRQLKAEKAEKSVIDAEVAALLDLKKQLAVLEGTDGKSGKATKTSFTLKTPKGTKDYNDKDMAIREKVFSTITQVFKKHGAVTIDTPVFELKEILSGKYGEDSKLIYDLADQGGEECSLRYDLTVPFARFLAMNGKEYQNFKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIAGVYDPMIPDAEILRILCEALTNLDIGKFTVKINHRKILDGIFEVCGVPEQSIRPISSAVDKLDKLPWADVKKEMVEEKGLAPECADRIGEYVKLKGSRELLDTLKKDETLMKNANAAAGMKDMELLFDYLDVFEVTEKMSFDLSLARGLDYYTGIIYEAVTEKSAPPKLAEGVVSKKKTNSDELDESTVGVGSIAAGGRYDNLVGMFSGVNKKGVPNLQIPCVGVSLGVERIFSILMSKQKSEEIKSNETQVFVIAVGDGLLKERMQVAKELWDAGIKASYMFKNKPKLDKQFAACDKDMIPFAVIIGKDELDKGQVRIKDMRSKDETQGGGVTIQRADMIQELKSRLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW29</accession>
    <name>A0A367IW29_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003252">
        <property type="protein sequence ID" value="RCH81852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW29"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="30506" checksum="FC649DD6C86852C2" modified="2018-11-07" version="1">MSQSTRPSRFIPQVRSASAAATPVASTSSPAAADTEELQRLRNEVELLRQQTIDAQRRFQQQLDQLAEQQAAPAPIRRKRAKLPGLSYHLREAYQLISSSKGISWDTTTSLYGSDVNIDIHNELLVAGKRYRSDSGQITSASQAQEEIKRIKECIRSQFESFQAKRRKLELSIEKQKEKERKARYGRRMAYKLKKRMVTINALTEAQTMELTRLNTLFKNLDEYYDAKKKPGMCKLRTREVVARVLDYQTMISLPAWGIVDNSSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWV8</accession>
    <name>A0A367IWV8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein memo1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003110">
        <property type="protein sequence ID" value="RCH82195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWV8"/>
    <dbReference type="STRING" id="86630.A0A367IWV8"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36228" checksum="BDAD42FE55581EBB" modified="2018-11-07" version="1">MSRPASHAGSWYQDDERALDQELNNYLNKATEAITMRGQQLPVQNVKAIIAPHAGFRYSGPTSAFAYTCFDTKNIKRVFILGPSHVCATRYCLLSKCKEYETPLGSLKLDISVIEELSKTGLFAAASPSTEIEEHSIEMHLPFVYKAFESKISDIKIVPIIVGSLTPDSKKEYAKALAPYLKDPETLFIVSSDFCHWGRRFRYTYYNKGRDDNEAVELTRSNSKKEIGRPIHESIEELDHRGIEAIESLSFDQFERYLSVTDNTICGRNPIGVLLAALEEIKQEGYSDQSAKCLKYAQSERCQSVEDSSVSYASIYIQVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY33</accession>
    <name>A0A367IY33_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002965">
        <property type="protein sequence ID" value="RCH82587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY33"/>
    <dbReference type="STRING" id="86630.A0A367IY33"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="199"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="35320" checksum="EBD71E4527306975" modified="2018-11-07" version="1" fragment="single">GYSQALEKARKELRFMLVVLQSDDHDDTELFCRQLIDYVKEKNILVWGGNVRETEAHKVSYTLQASTYPFLALIALQKPLGASTPKMTVIERMEGPCRAEELVSQIDAAIDRHGAVVNRLKNEREQREMERRLREDQDRAYRESLKADQEKVRKAQEEKEALVKAEEEEKQRQREKEIQKQKNEEYIRYLYTHLPEEPKEGKMTKLSFRLANGDRVVRSFSEHDTLDTLYRFVEVYPLLKSNEPVEPCESAPEDYVHQYKFTIHSPYPRKEYEADEHQTLSNIPSLWPSATLVVDAVDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ46</accession>
    <name>A0A367IZ46_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NHP2</name>
        <name evidence="11" type="ORF">CU097_006750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002867">
        <property type="protein sequence ID" value="RCH82859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ46"/>
    <dbReference type="STRING" id="86630.A0A367IZ46"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000015">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit NHP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH82859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="156" mass="17374" checksum="25C88E2D6A8F9788" modified="2018-11-07" version="1">MPKESKKEKKSKKSESSEVLRFQSPIAHPLADDKLAKKVFKTVKKASKVKHVRRGVKEVAKALRKGEKGLVVIAGDISPLDVISHMPVLCEDNNVPYIFVPSKEQLGEASSTKRPTSVTMIVLGGKNKDTKAAEDYKELYDECYAQAKDLDEKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZT6</accession>
    <name>A0A367IZT6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein fam72a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM72A_1</name>
        <name evidence="2" type="ORF">CU097_003932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002742">
        <property type="protein sequence ID" value="RCH83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZT6"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="188" mass="21550" checksum="2409CD86BA405586" modified="2018-11-07" version="1">MEYSRIPRSRSAVLLPHHQVTPPSVIQAQRRFQHSQSLQQQQSSGLVTPIKPVYSLTCKHCYMTICARSMKAILLADTRIELFSTDAPSQSMCVLDKDYLTRSCHCRIRDVACLKCGNIVGYHVVSPCAQCLDACNNGHFWMFHSKACDPVERKDERSKTLFWNKLPRAELDVEFLRGCQLPYDQLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0N6</accession>
    <name>A0A367J0N6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TNPO1_1</name>
        <name evidence="1" type="ORF">CU097_000210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002642">
        <property type="protein sequence ID" value="RCH83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0N6"/>
    <dbReference type="STRING" id="86630.A0A367J0N6"/>
    <dbReference type="OrthoDB" id="3005661at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="13956" checksum="550E8C962778A111" modified="2018-11-07" version="1" fragment="single">RTLLENVAITVGRLGLVCPDLVAPHLQVFAKPWLNALTPIRPNDEKLTAFSGLCEMIKINPQGAVQEFPLLCHAIANYQTASPALHESFGNILMGYKSMFGEAQWQQFLASMPPELKAPLHERYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0Y2</accession>
    <name>A0A367J0Y2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002613">
        <property type="protein sequence ID" value="RCH83594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0Y2"/>
    <dbReference type="STRING" id="86630.A0A367J0Y2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH83594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16221" checksum="7C9302BABCCB18CF" modified="2018-11-07" version="1">MSQPLQNTLSFLKTGNNSNISLEVPRSRSGSILRAISLHSNSSRYEDEESTSCNPEDFVIKNPIGYGSSAVVYNAIYKPKNMRVAIKMIDLDLFERNQIDELRRETALMALCKHPNLLKVYGSFVNGSKLYIATPYLSGGSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2W2</accession>
    <name>A0A367J2W2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002440">
        <property type="protein sequence ID" value="RCH84179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2W2"/>
    <dbReference type="STRING" id="86630.A0A367J2W2"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="1">
        <location>
            <begin position="179"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="44148" checksum="1E91F6F387E12500" modified="2018-11-07" version="1">MTNYIEIFTTRGTKGIDVTVIIHATIQKELKLAFNEFVLDTKQSHHLGVTSLVATVPPMPFINSRVAVHICFIEHGTIVDTRFIASFIYEQDTMNSSLIRAHSLKDYQPGLDLSGYVRDTTYPTLRSQPASATQSTPSMCLPYNDFSSGSAHSRITKASSYTDSISVAGYQFCHDLNRQIDLKIIGDINSVMYSWTAEERDMGRRLVQFWRQKEQTNITCVFKPVLTTQLDQPMTTIVSCIYWMERNDFFITSVDLIALIESLLGINFNVDEKNRVRRNLEGFRPVTIGKSKPESANFFKLIMSYPDPKPRNIERDLKVFSWRTLPFALQKIIAKYSTHSLTSKRLSHEQHYVSRLSGNIDLSKHGHEYIKGEHDKDDKMLKASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3U5</accession>
    <name>A0A367J3U5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_002958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002318">
        <property type="protein sequence ID" value="RCH84610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3U5"/>
    <dbReference type="STRING" id="86630.A0A367J3U5"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH84610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="257" mass="30166" checksum="7627A44AE29FEBBE" modified="2018-11-07" version="1">MPSHEEASSIIDRWFRAIEDQSPINLCFMTRPISRSMLGRIETLEGIYNRNIIYRFLIRKIHPVIVFLSLTTSLSYLATRLYRRSTRLVLTLVGVLYPIQRSWNLIRQREGTTEELNSWLTYWMIYGSFQVLDHWVDSDLLPKRKYNLYKLFILYWLQNPHSNGASVIYKHVLLKPSKEEDHNNKDMIIQPVNGSYRYLDGYIPPLPQADNNEDSSTDSSNSSISDDNEHLIQENHNVIPEEKQSFTLLLNSNEAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J588</accession>
    <name>A0A367J588_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002182">
        <property type="protein sequence ID" value="RCH85107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J588"/>
    <dbReference type="OrthoDB" id="10304523at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="310" mass="35673" checksum="3EC9B7FD6D92F0DA" modified="2018-11-07" version="1" fragment="single">TSSEYPHEFCDSCNKTFKDAIQLKNHHKNYHQSSIVISYTNYEGESKTLTLDRDEDDNFICPICSLESKTSPGLRSHFSRQKDIKKPKEHFRSQHFNYDVHIEEVGEKRKIGTPTYDDLFYDRDKDFKRIRAKPIMRAFGLDLINIDLKHNQNLFSTSALINEKTSRLLKRLPQPTEGSLNSSMTFPNNELQYPEKFTVCDLQKNIKISNFPCINDILGPYIKLNDDIEEKIEDLDLNHIVSIFPGSVIASDNFSLLVLTAEIYSRNGFMDAYAERSGDSYPESMIIQTNTRIGKSALLKKVKKVAQSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5G7</accession>
    <name>A0A367J5G7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Blue light receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WC2_4</name>
        <name evidence="7" type="ORF">CU097_008526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002164">
        <property type="protein sequence ID" value="RCH85182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5G7"/>
    <dbReference type="STRING" id="86630.A0A367J5G7"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052138">
        <property type="entry name" value="GATA_ZnFinger_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255:SF4">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="331" mass="37539" checksum="D6AD541872DF9372" modified="2018-11-07" version="1">MDSSQVVEISNLASQALTARSTQTSVPSGPHEFTRRKNWSQNILEELRDIIHVLSLDFNILFCSPASREFLGYQQGELMGRNFKEFIHVDDIDVFTREFRLAHTNGSILRSTLRFLRKDGKHVTLEIRGHFYKNAFFGSARSVPTEMTRTMDAFLNVKMENEILRRKLQLAKAQAAKKTAVTVPQVPQEDEYDDFEEDFEQLFTAVSNPNVYTQGVLNSFGVAESVNLFTGLQFDLGERSRGISMGLEGELFNTTYPPEIGDEATNETNKLKVGKKRRGTDDQPRICTDCGRTDAPEWRRGPKGPKTLCNACGLRWSKANKLQTTENNIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5Q2</accession>
    <name>A0A367J5Q2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002140">
        <property type="protein sequence ID" value="RCH85272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5Q2"/>
    <dbReference type="OrthoDB" id="2218807at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH85272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="446" mass="51542" checksum="DE6E2D472E494ED7" modified="2018-11-07" version="1">MYYSFDFIAKVTRLCIEEIRQRGFQERKIFRKTVPNYGLFIKIFNKRDFTANDLSYVDIHSVATLMQVALWSTPDRIISKKAWRKINYETCTLSNLSSIIPNKSQQLLIEILEFLVELLQHKHVNLMDAYKLGDSLGKVVLGPSDCSQIMEEKSGHFLTRLIIEHAKITSRKSAQLGLSYSRTDSGYDMSSVYSSVNYMEYQPLCKTEGTRARAKCYSRIIAKINRNSSDWIENADGIQKMMDNDYDIVPEPPEKPWISIFVSPDSLRESDKDMRISSSLYRILNEAVKAPAVVPEDPFEASYLFNKTKACFAEHQIHEAFNQFLQLQARTDQLTSNNIEDKANPLRKLNSSLSNLKLNIRRYRSRMDLLEDSAISEDTVVNESNITDSENINMHRHQYPIHYVQQQQQPSHNHHHQHKSGLSNMKGAMRKMAKMAGERKISKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6F3</accession>
    <name>A0A367J6F3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DAL81_1</name>
        <name evidence="8" type="ORF">CU097_000957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002078">
        <property type="protein sequence ID" value="RCH85518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6F3"/>
    <dbReference type="STRING" id="86630.A0A367J6F3"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="224"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="603" mass="68587" checksum="9084685AC3FE9E06" modified="2018-11-07" version="1" fragment="single">EYGILNPKQWLPGVKHDTIQYLGDLSTFQFLGSRLDLSREMKWEGYTIKRFGEDTVLVADRKEADVQQYSRLIPEIRWPKGMDSQGEDIHQYIYAVTGLDKHTAARLLKIYFANVHPILPVVDKTEFIDQYRGRMNAFPSGDLLNAMLGAAARFVEHQKAGYEGQRKLPSDVMLDVPIGWSNSFFDRAEHLLLNWSTTPTLSKIQTILLVLNTRPDRNIKSSESWQMGGFAHLLGLHKSCDHWDIPDREKETRKRVWWTLYITDVFQTAMLGRGVNLRDEDITVGYPDVTADWEEVMDAYEIDKDKILNKQPFPRFPSLSTPFKITVSVGKRAPIYELFLSLVKLSQINSRILLSLHSPRARQFSYEHGSDNIVATLDHELTEWRYSFSRTVRNSRIPDFNHQKGYFAPVVASILLLYFSTLILLHQPFLKKTASKSSTTSQQICTNAAKGGMRIAKGMGIKEFLMCPYAAVTYPLRQFGLIQVINAKNPNPEISVTAKEELKQGMALSQMIEPMSFGAHHTNKFYTVLLNHLEEYEKYKSEDPKLNANMGYTSQAVNAQQQQSIIEHSGTAPMNAGPFLFPTLSPFVTAMNPSMAPVALYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6K8</accession>
    <name>A0A367J6K8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RraA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002063">
        <property type="protein sequence ID" value="RCH85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6K8"/>
    <dbReference type="STRING" id="86630.A0A367J6K8"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16412" checksum="DF198F86C1582395" modified="2018-11-07" version="1" fragment="single">MSLEQLKQFSTCEIADALLKLGQRPWGGYIPDIEMWSPTYCEGDTRIIGPAFTVKMVHKEDKTSPTPTEHFADAAESGSIIVISAPSDVKNAVWGGLMSARAKTKGAKGVVIDGRVRDLNEHRQMQFPVFAKSHSILPQNAFVRPSEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6M1</accession>
    <name>A0A367J6M1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MAP2B</name>
        <name evidence="13" type="ORF">CU097_005811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01002067">
        <property type="protein sequence ID" value="RCH85560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6M1"/>
    <dbReference type="STRING" id="86630.A0A367J6M1"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="109"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH85560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="419" mass="46594" checksum="AAB654F28C15AA2F" modified="2018-11-07" version="1">MVAAEEVKQVTEKLEETHIESAEENHDQATEDTGAGSEAAAKKKKKNKKKKKGPKTQTEPPTVPVSKIYTNKVYPVGECHDYVNDNLWRTTSEEKRAEERLKEEDYNDLRKAAEVHRQVRAYARKMIKPGMTLTEIAELIENGTRALVEENGLEAGIGFPTGLSLNHCAAHFTPNAGDKTVLSYDDVMKVDFGVHVKGRIVDSAFTVNFNPKFDKLVEAAREATYAGIKEAGIDVRLCDIGAAVHEVYDSYEIELDGKTYDIKPIRNLNGHTIEPYKIHAGKSVPIVRDSGDETKLEEGEQLAIETFCSTGRGYVIEDGECSHYAKSTDSGFVPLRLARAKSLLSTITKNFGTLPFCRRYLDRIGEEKYLMGLRNLVDAGVVTAYPPLVDTKGSYTAQLEHTILLRPTCKEIVSKGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6Y8</accession>
    <name>A0A367J6Y8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002057">
        <property type="protein sequence ID" value="RCH85599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6Y8"/>
    <dbReference type="STRING" id="86630.A0A367J6Y8"/>
    <dbReference type="OrthoDB" id="2288451at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017000102" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16373" checksum="FB9AC9FFB28C2054" modified="2018-11-07" version="1">MKLILFNYFFPATLIVLFHTLIVSAQSPDPFPSPNSNGFNTDGNTMEESHESWLKKNDRYIFIIILVLILVAIIIWYITRSLRGMRKRLDEENRQNMMMMQQTTVGRNDITETIPLPSDSFHKLPDYSSQQQQQYAHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8M0</accession>
    <name>A0A367J8M0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001903">
        <property type="protein sequence ID" value="RCH86278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8M0"/>
    <dbReference type="OrthoDB" id="2213741at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="10874" checksum="6C00B1A106A2883C" modified="2018-11-07" version="1">MHGYESKLPLICRSILPIDPVYEYPCHTKNVVAVFNGVLTGCLEIDPSVSLVCSLGRVLSNAPVGITGCAFHYRSEILCRFYLTSFPVNPRISARCADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9I9</accession>
    <name>A0A367J9I9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001853">
        <property type="protein sequence ID" value="RCH86499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9I9"/>
    <dbReference type="STRING" id="86630.A0A367J9I9"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="269" mass="30051" checksum="5D63A664D1B690F7" modified="2018-11-07" version="1">MQSIHVQKAASAIKNKAALPDPKKVDLKFDYSPSQDGIDHNLLILLHGLGDSKTPFTRLGQQLKLPQTAIISIQGPEEVPYLDGCFQWFPSFNLLTGELLPPGHPEKMKGLLNTRSKINKLLEHLVNDCNWNPPNIFLFGFSQGGTVALDTALFGKVRNLGGIISISGYLLEEQSTDSRIDEGYPGYILITQGERDETMNKPIAETKFKQIKKLCSSSAEVSQAFIPNKGHTMPSTEQEWRLIHTFFGKNMPRRNIELENMSGVYLVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA16</accession>
    <name>A0A367JA16_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="17">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HEM1</name>
        <name evidence="20" type="ORF">CU097_003526</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="17"/>
    <dbReference type="EMBL" id="PJQL01001796">
        <property type="protein sequence ID" value="RCH86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA16"/>
    <dbReference type="STRING" id="86630.A0A367JA16"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015118">
        <property type="entry name" value="5aminolev_synth_preseq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09029">
        <property type="entry name" value="Preseq_ALAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="5-aminolevulinate synthase presequence" evidence="19">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="18">
        <location>
            <begin position="136"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF09029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="549" mass="59774" checksum="ECB55D78558EC951" modified="2018-11-07" version="1">MEVALMQAKKSCPFIHLASASSLRRMTSSGVNPLITKAKQCPVMSQAISARALSTSSVVKQTPSKPVKASIATHNNQGPKIVPPVAHQTQKHFDYESFYQEELDKKHRDKSYRYFNNINRLAQKFPRAHTARITDEVTVWCANDYLGMGRSPVLTDAMKRTLDRYGAGAGGTRNIAGNADLHLRLESELADLHHKEGALVFSSCYVANDATLSTLASKLPGCVIFSDSLNHASMIQGIRHSGAAKKIFRHNDMKHLEELLQAVDPSVPKIIAFESVYSMCGSIGPIREIVDLAKKYGAITFLDEVHAVGMYGPRGAGVAEHLDYDLNASRPVMGNGSVLDDIDIITGTLGKAYGVVGGYIAGSATLVDMIRSYAPGFIFTTSLPPAVVSGAMESVKYLKRSSTERQMQQINTRTVKSRLDDIGIPVIPNPSHIVPVLLGDAAAAKLASDELLSEHDIYVQSINYPTVPVGEERLRITPTPGHNDVMIDELVHSLDKIWNRYGFKRVQDWTAEGGRAGVGIENSVQLEPMWTDKQLGLDAANKVEAAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAK1</accession>
    <name>A0A367JAK1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001767">
        <property type="protein sequence ID" value="RCH86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAK1"/>
    <dbReference type="OrthoDB" id="2226573at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="9457" checksum="E83042D47F651D15" modified="2018-11-07" version="1" fragment="single">MQQNEYRALDLAYSMDYWRWLSEKEKDEQRKDTAAGIITKRSNFAEVPKKTRKNKNTYLAEDHLNINGYRESLGTIIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAR9</accession>
    <name>A0A367JAR9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud neck involved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BNI4_3</name>
        <name evidence="2" type="ORF">CU097_010323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001744">
        <property type="protein sequence ID" value="RCH87028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAR9"/>
    <dbReference type="STRING" id="86630.A0A367JAR9"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="32516" checksum="4A8EFA3F027CCA8C" modified="2018-11-07" version="1">MAMNEHDMNQIIHEVQSLSIDYNHHRNDLNAITQSCIWENEDKVDHHAVIQSYLDPQCMLHNSLTSLHEKKRLYKMKSALKRVLGLKQKKHQPLPVISHDASLSSDSGCTSTTVAGQSIKSLTMADNDNDNDGNDDDDDTISQNTSTTAQHRLSICGLPICPFRNKASMAHPKQSVMTKSILKKPNKSTRWSSVTLRRKTQISNLKKRKSHLGSMRLTIQFNQYVTVYETYSRQDYDRTSDPEAICTRLTPVIAQEIKQELNHFKLYEMPVHESSRMYTHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBY3</accession>
    <name>A0A367JBY3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_004815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001657">
        <property type="protein sequence ID" value="RCH87438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBY3"/>
    <dbReference type="STRING" id="86630.A0A367JBY3"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH87438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="348" mass="37931" checksum="C25A0072B36BFFE6" modified="2018-11-07" version="1">MSNNDTLTGWASVGKGKPLEQMQFPMKAWDDNSVEMDITHCGICGSDVHTMDSGWFPTDYPTIVGHEIAGVVTRVGKNVTRVKVGDRAGMGAICGACGQCHCCNKGAENTCLKGAVFTYGARWPTGEKTLGGYADKWRGDETFICKIPDNVSNENAASFLCGGVTTYAPLRRWKVGPGSTLGVLGIGGLGHFAVMFGKALGATVIALSSSNRKRDDAMKLGCDDYVVTSNEEEMAKYANKLTHIICTGVGEDFKWEPYFNLLLSDGIFINVSAPEFQYPSIPIFPQLMKQIVVVGSAVGSVKDLDDMLQLISEKNLKAWYKKYPMSEVNKAIEDFRAGLPRFRFVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCV3</accession>
    <name>A0A367JCV3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001632">
        <property type="protein sequence ID" value="RCH87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCV3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7635" checksum="67A6913CE5CF286C" modified="2018-11-07" version="1">MNLTNNYDLSIGTDLISKLGIGFDCKRSYDDFSELLTEADRELSDYENVLQVLLVNIKKSWMRSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD35</accession>
    <name>A0A367JD35_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001583">
        <property type="protein sequence ID" value="RCH87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD35"/>
    <dbReference type="STRING" id="86630.A0A367JD35"/>
    <dbReference type="OrthoDB" id="2238692at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="405" mass="45488" checksum="66DF6B47A83A867E" modified="2018-11-07" version="1" fragment="single">MYSKLFTRSIKQQRFMQRRNYVVAKNDLRANDSKGLIFAGLAVLGAGSYYYYKKTNEDDNLPSDLKKKVKNTVNDTTTHHKAQDNPMVAEKVSSDKSKPDWESKLEQGSKDTNKDTSRLVGKDTDKVKGVWENKDKDDQVSRTPASVNEQNEGSSFWNNLLSGNNEQTSGAPKTNLEAQDDTTKKGSFSSWVTGSNERRPSTGNPMVDEKLYPGKTKTEKDERMEAYANDVIHDTSNLVEKDTDKIKGVWERRSKPNITDSPNEEKKSFWSSLFGSSKEKEADASWNSAKDKLNDAKEDTASTAYRDAQRLSGAWGDAKHAASAESDRLKQDANATWDRTKDRAYADANSVKNQAESVWDHASAKANNAYDSAQEEGARLKREASDEYNYQKNRLSGSINGLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD64</accession>
    <name>A0A367JD64_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HIS3_1</name>
        <name evidence="10" type="ORF">CU097_008642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="PJQL01001576">
        <property type="protein sequence ID" value="RCH87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD64"/>
    <dbReference type="STRING" id="86630.A0A367JD64"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="21399" checksum="1279DB152410EE8D" modified="2018-11-07" version="1">MEARTAVIERKTNETDIKVSINLDDKMNQEIKIDTGIGFLDHMYHALAKHGGWSLELHCKGDLYIDDHHTAEDTGIALGMAFKQALGTPKGIQRFGSAYCPLDEALSRAVVDISGRPFADINLDLKREKIGELSTEMIPHVLQSFAGAAGITLHVDVLKGQNDHHKAESAFKALAVAIRQAASRTGTDDVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDR1</accession>
    <name>A0A367JDR1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001547">
        <property type="protein sequence ID" value="RCH88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDR1"/>
    <dbReference type="STRING" id="86630.A0A367JDR1"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="188"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="300" mass="33328" checksum="F44CD1C45584A01A" modified="2018-11-07" version="1">MFKQVLTVTSRQYTMLQKRSFASLISVQELKSNLENVKILDGSWHMPNSNRDPYDEFLKKRIAKSQFFHIDGIKDTSTDLPHMLPSPEVFANAVGKLGIDQHDHVVVYDTVGVFSACRVYWTFKAFGHDTVSVLNGGLPAWDGPTESGVPEKVQEKHYKVPTINTQIVRDYPTILANARKAQSNEDYIQVLDARPYARFTGQAPEPREGLSSGHMPGSISVPFNEVVGPDGKLYDDEKLKQIFQGKGVDLSKEIITSCGSGITASILFMALERAGAKNLAVYDGSWTEYAGRNDAIIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFI1</accession>
    <name>A0A367JFI1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell cycle RNA binding protein whi3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">WHI3_1</name>
        <name evidence="6" type="ORF">CU097_000236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001431">
        <property type="protein sequence ID" value="RCH88635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFI1"/>
    <dbReference type="STRING" id="86630.A0A367JFI1"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="330"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="446" mass="49627" checksum="A861AFEB05E2670F" modified="2018-11-07" version="1">MFLFSSGFEAAMLKVPSLKDGDDDLANNIKKQIIGFAKFRTRKEAIEAKDVLNGRKIDPEKGNTLKAEMAKKNLHTKKLNITEQQQEQHTMEQEELQKIQQPTPNRFNTAYEAFYSVPPSSVPKDLMSPITTPSSMTNESYSDFYSDLAFVGSPPPVENFISRSQSVDARSMDLFIRPSLSSSNNGRFQSRLSAVAANRFHNGKELEFDYLSKSTPHDNSNDRSFHPHIIPSSQPQQQHYPHHILSPPLRPMSTVSTGLMNHHDPPHHFSRFPPFVHTSNSTPPKSISPAPHSPSPPPPPGILSPNHSYRSLGGMLVGSTNPADQNPPCNTLYVGNLPPNANEDELKSMFSKCAGYKRLSFKNKSNGPMCFVEFEDAIYAAQALQDLHGNPLSNSVKGGIRLSFSKNPLGVRQSNNNNNNNNFSIMNTLSNRRESITTSHFDPQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFY8</accession>
    <name>A0A367JFY8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Swr1 complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SWR1</name>
        <name evidence="15" type="ORF">CU097_009208</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001399">
        <property type="protein sequence ID" value="RCH88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JFY8"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="126"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="462"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1206"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1242"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1284" mass="149177" checksum="52BAA11900492109" modified="2018-11-07" version="1" fragment="single">NLVNDLIYQKFIQDFNLWDIAYNTSQHKNTVQLLESVFNSTKQATSAAASSNYQTIRSGTGTRRLVKQYKKLNDYLSTFVTATDDEEMTPEAREALIEKERSIRQRLNQLYQAGGFTTQLQAIAHRRPHQFPRQHDLFHDTLLAHVQSSAKLFAANSKYRRNMARKCARAVERYWENIWAQDERAKKEETKRLIRLAKVVAQEVKKKWKIVEKVCEARQKELSKEAQAKEGRRHLELILEHSHHVLGMRREELDKQQEGLDEEYVYTDEENLSDHVIEQNDEESDEDELHELENDQNAQLSVEELMKKYNYAEPTDDHAEFTPGSDQEEDIPLENDGESEDDDAEINALNEDADLPIDQLLQKYNYSAQDNVTQLNDEKEIPLSALMDTEFTGGQPRETKDTTLSPASPSPSDTSSTRTRRSSRKIQPTGNTLLTTKVRTKIPFLLRGTLREYQHVGLDWLASLYNNGLNGILADEMGLGKTIQTIALLAYLACEKRVWGPHLIVVPTSVILNWEMEFKKWLPGFKVLTYYGSPKERKEKRSGWYKPNAFHVCITSYQLVLQDQNVFRRRAWQYLVLDEAHNIKNFRSQRWQVLLNFNANRRLLLTGTPLQNNLMELWSLLYFLMPNGVSQDMPIGFANLKEFQEWFSHPVDRMIEGQQGMDEESRAAIQKLHTVLRPYLLRRVKADVEKQMPEKHEHVVYCKLSKRQRFLYDDFMSRAKTKETLASGNFLNIINCLMQLRKVCNHPDLFEERPILTSFAMDDEVQTEGSYLESLIRRRFNVVQPMERVNFDFLNLILQHPHMNKMSQIVANEIIRLAATEAISKVIANRQRHIAAAEARGIVSKDYHDLKKYAKYREMQMQIQCMKRWESIQYVNSMRCARRPFFGSDLVTLLRSMTSNYRDRLFSSSARIYMSQCDAIREMVQGYKGRIYSNLDILEQYGCVTPKAVVWPKERILPYEGQLQLQQVNSIDNDIFHPIRSRLSIAFPDKWLIQYDCGKLQKLDKLLRELAAGGHRALIFTQMTRVLDILETFLNIHGYRYLRLDGATKVEQRQILTEHFNSDKRILCFILSTRSGGLGINLTGADTVIFYDLDWNPSMDKQCQDRAHRIGQTRDVHIYRFVTEYTIEENIFKKANQKRMLDNVVIQEGDFTADFFNKTDWWRELPEVVGASERSVYTPVDYEQALLEAEGDETDAQAAMVARKEMNMDDNDFNDTPSAVTRQSSEAPSQAPSQTVSQASQTEEDPTMDGDVELNVGHVDQYMLRFWEREMLGIDLGFGGFANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG33</accession>
    <name>A0A367JG33_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_002321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001397">
        <property type="protein sequence ID" value="RCH88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG33"/>
    <dbReference type="STRING" id="86630.A0A367JG33"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="271"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="429"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="613"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="84168" checksum="4A01EFB18AD0C0DF" modified="2018-11-07" version="1">MPNDRLIKSSSPKQRVTPFVVKRKQINFNLLDTTSPQIPSSESRHIYEQLLKDKDEKIKDLKNQVESLHKELQQTRHQCKLLENERNDYESSINEKYAKEKIQVETELRILKETHVEKVQNLSTNLNHLTCTVHSLRKLLEQHNIKEEIKENDILLVNPIYKKDALFIQDAYQQIKQEISNQQHPMWSNIQATAMAIKHEINVFQAWKSACNLPVHELAKAMLKEQKSKKTLFDTLPSPPSQSKASVCTSIGSPMTKDQLRYCAAIIRNLKKHRDAAPFLNPVDYVKLNVPDYPTVIKKPMDLLLVDQKLSRNEYATVDEFVADVRLIFNNCFKYNGPEAMISVLCQNVESAFEKSLRQMPPHTKELSPPISQNNSPYEETAVHEYYESRPKREIHVPSKDYPEPYTAPATSKAMKYCMQTLREMKKQKYKHLSYPFLYPVDPVALNIPDYPTIVKCPMDMSTIEQKLNRNEYKSPDAFAADIKLMFDNCYLYNPSHLPIYQIAKQFEAVFNEKWAQRPKEEPQPPAKKPASRRSSTKQQQQQQQQQQQPAASSDEDKIAELERHIANISQQIESIKSSSKKSTTSRKRSTPSDKTKKETTPKKKRMTKYREISSDEEDEVMFTFEQKKQLSESINNLSGESLNTIVQIIQSSMPNLSSQGEDEIVLDIDSLDIKTLKKLHEFVNSGTASSGKKAVRKERHHSDGGSSSDSDNNNNNNNNDSDSSSDDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGI1</accession>
    <name>A0A367JGI1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_009030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001361">
        <property type="protein sequence ID" value="RCH89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGI1"/>
    <dbReference type="STRING" id="86630.A0A367JGI1"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="4"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="612" mass="69120" checksum="6848495AF8A6955A" modified="2018-11-07" version="1">MFLKERLFLSEAFIALLVGVLAGPLVVNGLNPYTWKDYHEITKQLTRCIIAIQVMAVGIELPQHYLKKEWRTVLMFLIPVMIYMWLVSGTLIWGLIRPLSFLESLVISACICPTDPILANSVVKGRFAEKHVPPHVRNALAAESGANDGMGFPFLFLAIFLISEDSVGKAVGKWIYITCLFQIILSCVIGVVVGYIARKALQWSEKRRLIDKPSFLSFAIALALFLMSVTGFSGSDDLLACFVAGNAFSWDEWFRRETEEAHFQEVIDMMLNLAIFVYIGSIIPWWEFNNHELGLEPWRMVLVAFLVLFFRRLPVVVLLKPAMPAIKTYREAVFSGWFGPIGVGAVFLSTIAKEELETVYEGKEKPLATQIVGPVVLFIVFSSVVIHGTTVPLFKLGRTIRTRTVSVNKPADVAAVSEKADHQDDQERGMRTADEKKDEQTLNGSTILAKSLENNRQVIVDMHASDFEYPEEDFLPDDVSDAIASTKYDLLTNTASRSLSSVRTRASGSKTSVTFASNVGATTKLVEPPKHSTVDKKKKPEEVVSLKTWFFRSNSASRIQKRRRQKEKERKRRIKEDKRILKEKQKEEKRLLKERQRTGITNPTIRVTEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGJ4</accession>
    <name>A0A367JGJ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SUB8_5</name>
        <name evidence="10" type="ORF">CU097_010653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001352">
        <property type="protein sequence ID" value="RCH89082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGJ4"/>
    <dbReference type="STRING" id="86630.A0A367JGJ4"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF13">
        <property type="entry name" value="SUBTILASE-TYPE PROTEINASE RRT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016933806" evidence="8">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="156"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="52580" checksum="3D98444FB08E2D2B" modified="2018-11-07" version="1">MITILFLLCLYFYNVVLASIHNNVAPVVSELKDTDQYIIIFKPEVSSIKIHNQLKNIQLHQTTKHKSHHTSKLHTVNNSYSSIGKFKWYSAQFYSEPFEEYLSTNQTVNDTVHYWVKDTQFSLQEFIQTNPPSWGLDRIDQREGLDNEYRFASSQGTGVTIYLMDTGIREDHNDIAGRVTIGKTIVGDPNDPSDKNGHGTFVAGVCCGTKYGVAKNAQIVSVKTLDDEGNGRLSDVLIGLEWIVQQHKSQPNAKSIVNLSLGALYSQPTNDAITAAMSLGIHFSIAAGNYGDDACKYSPGSTPGAITVGAFDQDDSVSYYSNFGKCVDIFAPGTNIKSIWPTSQDATHVLTGTSMAAPHVAGTMAIFLSQANFTPPELATYLKNISTLRTEDFTINNTGAWYSENKTVIDNAIDVGYQVQNLMNQKTRVNLLYNHPHDGQQFWVYGRTLNSASILSFNFMIPLFTAIITFIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH96</accession>
    <name>A0A367JH96_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001312">
        <property type="protein sequence ID" value="RCH89310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH96"/>
    <dbReference type="STRING" id="86630.A0A367JH96"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="656" mass="74989" checksum="17E91BE4CBC24667" modified="2018-11-07" version="1">MPRVLPEDVKNDIKVALLHRREPSDIAKEPGIHAATVRRYRKRFSLQSPASAGRHSIIPDVGKRYIKLFVIRGQLKTAKKVYRKLTELGGIQIAVNYRIHVYTLDAMSSSFKDPIRTLASPQALNTGGGPESPHIINAIKVGNMLGREILVSVSEWGEVCVWETEDLDKPPIILRNEHKTWGIAIHGEQGLLAVSANNWKIKIYNMAEMTKNDPSYTPRKLPNVLNDATEVILEGHEHNIPCIDFNETGEYLASASIDATTKVWDIRSKQVVTYHRRPAIRNQEQDTWCWSTKFIKPGHFKYITCTDTKINKRFVQRLDQGRSTSLANLSLCHSANAPIYPTMDIGRILDLNADDIEDEILEEEINDDLWDNSLIRQEESVVADYILQQRERLSSASVISSNTVSGDEERDAWNEPVQGVEEIPMGYRPRSQLENSYGQILQSVLRTRLEQGELFESQSPSSSSMISPTEEGWDDTDEEETTTWDATHTEDMEEEIYEEEEEEEVCPSYCIPKIIQNLDNNANRRKANQPNELDEYLMLSTAKDIVLMRTTLPKMTKVRQESDIISKVDVRADRLLYLLDRITMIEWIPELELFVTASQKGTVALTRILQLELEDGRQTCVFNNEYYLPIDVLQTTPLYGKLWMLSSFITNYQLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIG0</accession>
    <name>A0A367JIG0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001237">
        <property type="protein sequence ID" value="RCH89720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIG0"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="137" mass="15995" checksum="3EF3A6B651E78038" modified="2018-11-07" version="1">MDSQFAPEEDLNNTVDSYSVTINGFIFCTRHGLEVCDKCPTDNRSANNMIVEDMLHEKMTEEEYTNKWKGDDREPLSVAHKWTRVEKGKPGCMEHKKVACEECFNWGEKLYRSVHGGRKPRVSRLQRKNRENAERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIM0</accession>
    <name>A0A367JIM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PPH3</name>
        <name evidence="10" type="ORF">CU097_009726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01001229">
        <property type="protein sequence ID" value="RCH89777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIM0"/>
    <dbReference type="STRING" id="86630.A0A367JIM0"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="36391" checksum="B95D09F861108587" modified="2018-11-07" version="1">MTEVIEGDVDSIISRLLEVRGSRPGKQVQLGENEIRYLCQKSREIFMNQPILLDLEAPIKVCGDIHGQYYDLLRLFEYGGFPPDANYLFMGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHESASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAVIDEKIFCMHGGLSPDLQSMEQIRRVMRPTDIPDTGLLCDLLWSDPDKEIVGWSGNDRGISFTFGADVVSGFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPAEKKAKAGSNNKQKNTKGRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIW8</accession>
    <name>A0A367JIW8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001220">
        <property type="protein sequence ID" value="RCH89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIW8"/>
    <dbReference type="OrthoDB" id="10507137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="52" mass="5876" checksum="B9A74498E67D3584" modified="2018-11-07" version="1" fragment="single">YLDDIDRTLPYNNRPGTDLINKTVLTDNQAISMLMKALVPEVAEDHYVVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJB5</accession>
    <name>A0A367JJB5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001227">
        <property type="protein sequence ID" value="RCH89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJB5"/>
    <dbReference type="STRING" id="86630.A0A367JJB5"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="39"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="256"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="73270" checksum="35A6EFD24B826C16" modified="2018-11-07" version="1">MLLFKGYVFVKGFVRNYSTTNTLSTLRHYQKECIETCLKELKEGCYRQVVSLPVGSGKTVIMSNLIPRIPCPTDKANKVLLLAHRQELLNQAYNQIKRYNPNLTVEIEQGKRVAKYETADVIIASVPTLGRSKSNRIDNLDPSLFKAVLIDEAHHAVADSYQNIIRHFSESSNKVLIWGCSATVRRHDGLSLADVFEKVTYHMDFLDLVEQGYLCPMKVTTVQTSIDLSDVRHYGGDFVISQLSNAVNIRARNDVVISSWKNYAAERQSTLVFAVDIQHTQDLCNAFRQQGVEANFITSKTPEMTRQQIIQDFRDRKLPVLVNCAILTEGTDMPSVDCILMARPTRSATLFQQMFGRGLRLHKGKEDCLVIDFADNFERGGTAGIVTIPTLLGLSSKKELTNVDILDLEKQAEKEEQEIEGQEKEVRADDKTTKRGDAQEENLPQADDGIDSDDSKIQIKVTEYGEIKELMADISPRKDVRAASRNAWVEIGDDKCVLLVLTQGSLILERDESSNLWHGFFKYDKRNTFAKRHSIPITSDTLTDAIRAADTWLRKKFSNSYIHNLIDRNARFRFAPCTEAQKDVLDGYNIKPKLKLTKGQAMDLITKVKYGQLKLWKEKHKKSKKEFEERQKLALLRRKPVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKF6</accession>
    <name>A0A367JKF6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001126">
        <property type="protein sequence ID" value="RCH90413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKF6"/>
    <dbReference type="STRING" id="86630.A0A367JKF6"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="96"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH90413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="534" mass="60306" checksum="485F8EBF0A469481" modified="2018-11-07" version="1">MTPRRSSSPSIVVNTSKSSSSYTNNQEIFLLATTRVHTRVRAKTFTDLSSDDVPLIPQPPFDFITQSLQHQQEFSPSFEKLRTLQSINILSILQFHPMMTAYQLTLIESAIFHNVTTTALLNHTPKSPDPCIVASTDFFNYLTRLIEYSILIKLEASDRSQHLNYWIKVADKCHELKNYQTLKAVISALGTPPMQRLKRSWAFVPKKAITLLEELVELMSEASNYEKYRLAMLEDIKLHEPMVPFLGTFIHDMTYLNALNNQQDARITELLSLFTDMQKNPDYSPALPAMYTKEVISYNRPKFSIRATASTRKGVYDDELAKINMDMQQCLVTQYLLTRPWVNEKTVDELCVLREPAKANGGVCLTSSVSLTTTRSSSGSLTSSSTSPSRPLSLDDEEDYFERKSSAGFWLFGRKSVDQSTAFKPVESFATLHRSPRHFSFDEVNADTDENVCIKKRYHGTVTSQSSSSLAIFRKDFWKNNSNTNSSSASNGSNKFSIISFNSEPSISSVTHNTTSPHPLDNSQPDTSSSFVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL59</accession>
    <name>A0A367JL59_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001096">
        <property type="protein sequence ID" value="RCH90609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL59"/>
    <dbReference type="OrthoDB" id="2217162at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="95" mass="10660" checksum="0C1CACB612A6FFD4" modified="2018-11-07" version="1">MNNLFRSSNEEAVSHVSNKAFSMGCITNGSRPDYIVEVYGNENNRYTNVIGEIKIKETRKKGITVDLYRIAIFCKEAMDKHNLGTVIGFQAVGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLG4</accession>
    <name>A0A367JLG4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001107">
        <property type="protein sequence ID" value="RCH90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLG4"/>
    <dbReference type="STRING" id="86630.A0A367JLG4"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="46036" checksum="072426AD5E6E7EC0" modified="2018-11-07" version="1">MCIHIYMRDNGNVLYPFHLHLLQIMDLLNLATEGFQSMAISSALFLFTGYLVYVRYRRYEYLNSMIKKYPDPEVVLENHDIAMEIYSHIFRKEFPLFARSSLEFALFKPFATPSVSKLLVSTREFLDRCPRRAEDTELILSEIIDPYPRIENQRLVTPHISEKEIMKQYERREASIRRLNELHGKYPISNEDYLYTLVLFVAEPLRWINNWEWRKLDIREVNAIFKVWHEIGTKMNIKDIPDTLEEWYVIQKEYVESSVKYHPANWTCADPTIKHLGKKLPGFMLPVVYKMLPCLLEKSECDAFGISTASLLMRIIFNTLICLRAWFIRYLCLPRKVFDLRTPFHANEQGKYVPHYFVYDPPIYKDGYRIEELGPEKFMPKCPVFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLG5</accession>
    <name>A0A367JLG5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SNX3_1</name>
        <name evidence="14" type="ORF">CU097_012821</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001081">
        <property type="protein sequence ID" value="RCH90709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLG5"/>
    <dbReference type="STRING" id="86630.A0A367JLG5"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH90709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="78" mass="9157" checksum="AACEA24A238E81F9" modified="2018-11-07" version="1" fragment="single">DFEWFRDVLERESTRVNIPPLPGKVFTNRFSDEVIEQRREGLERFLQIVAGHPLLQTGSKVLAAFIQDPNFSRDSYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM22</accession>
    <name>A0A367JM22_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001075">
        <property type="protein sequence ID" value="RCH90741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM22"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10211" checksum="01239F2066508481" modified="2018-11-07" version="1">MDCAPELGEDSAELPGITTRHNMIETEKPPLFLFVSDLTNIAPALRKTPQYFPCIAEIAETKYILQGKVYSAELLGVHFYTVSKIAFSGTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMH4</accession>
    <name>A0A367JMH4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TEL2, telomere maintenance protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TELO2_1</name>
        <name evidence="7" type="ORF">CU097_011022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001016">
        <property type="protein sequence ID" value="RCH91127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMH4"/>
    <dbReference type="STRING" id="86630.A0A367JMH4"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057348">
        <property type="entry name" value="TELO2_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25320">
        <property type="entry name" value="TELO2_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TELO2 ARM repeat" evidence="6">
        <location>
            <begin position="250"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="5">
        <location>
            <begin position="500"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="790" mass="90128" checksum="7624AEF20F1D8CA1" modified="2018-11-07" version="1">MTTTQEFITQLDQLTHADSLDKVLECIQIPLGWLNITESPLTASQQLALVQHKAWRRHLWHLFHTILPNWTFSLSPHREKLLSTLWLKDQRPEIGAVMAKTSLTVLLECITQEVPLDTLETYTAGLKHVTLGAYKLYPSQIEHDQVDLFCSLLCSVPGRLVNAFGGHQQSEAWYSDKQFYPKLTKLAAQHASQSVGFTSQLLCKMIRQGYEDSVIASIIPVAIQSSDVFPAIFERMYNTLSSFDTVIKSILHYALTHHIRAHQIACILFTSQEQTRIKDFLVCTLVRLARWSLADQTLARLATATAKHAGLNDWIECTKQVIHAWSDTVFIKHASLREKRYVSTSVLVLLSYLEDDDIRYHIMPDTRLIRSVSFYLDSGDIETAKLGALVAEATSSRIDKENALNMGLLDEDKELQALRQIVFKTEEDDEQDKQVVPAASFEEEQEDTDQEEKEMELDPDAAYHPQDDSDDEFQAYAIEDESDDEGLRRDQESKETSKKPAFVQDLVRYLRHTEDPVSLRNGLNEAEAIIRKSIGVGTALKECGQELAKYLVYFPETYEIEDFRQLQQDALQALIVGAPDVVTGYMIDLMYDRNTNMGQVQTILASIALAVRELAGWVPTDKTKGTEKQIDALADQLGVSLFVSKRIELERNRPKAQKNRLAGLAGPVFFFPLLVGWWEGSQGRLKYWIGNNPNVVERFIMTLNIIMHSSTNTPDKRRIVREYFEFSFSMRYHQATQCQKALLLGIETILNVSYKGQESLLFNDFMSELINTKEWLEGKKKSSFYRNDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMQ4</accession>
    <name>A0A367JMQ4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001013">
        <property type="protein sequence ID" value="RCH91149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMQ4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="55" mass="6438" checksum="C93051914640025D" modified="2018-11-07" version="1">MFIKRDLTKARALSQSAEQQVKEETERVIRDLLQQQALLDELDKSSQLEALVFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN34</accession>
    <name>A0A367JN34_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000981">
        <property type="protein sequence ID" value="RCH91354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN34"/>
    <dbReference type="STRING" id="86630.A0A367JN34"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20802" checksum="7F0C26D19C19C3DF" modified="2018-11-07" version="1">MPDDAVVTERDPLIIPPPTVWTRFNEKYRFGKLILVAAGCLGIIIVMLSVLGGLGVYKNTRYRNQVGISSIGKTRYKGDSWGTAKPGEFTMGGQGDATYYDPGVGYTSCGKLFTASDMVVALDGYDYGSYADPNQSPVCGACIIITGPLGSTKATIQDMCPSTSCGRGSLDLSPAVFAKVGDFFDGRIPVNWTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPK6</accession>
    <name>A0A367JPK6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intersectin 1 (SH3 domain protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ITSN1</name>
        <name evidence="6" type="ORF">CU097_004025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000908">
        <property type="protein sequence ID" value="RCH91873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPK6"/>
    <dbReference type="STRING" id="86630.A0A367JPK6"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="656" mass="72983" checksum="BB476AB373481783" modified="2018-11-07" version="1">MNVESYCKALYDYDTDQTDELSIKEGEIVRILNKDNADWWLAEKIGQSTASGLVPSNFLETVHLGVVVRDYEAHDDRETSLKRGDRVILLENQGEWTIVEVNGKTGRVPSSGGIGSILAGGILKRSSTIKENEEEGPKPPPRPTSDPKNMTTKAMVIHDYSAENNDEIELMRGEHVTVLEQNGEWWKGSNERGQVGIFPANFVQIIDQTPPPRPTRARPATVQKQEESMGAGGPPPVPVGTRPTSLLTNRESPSPSRTLTSPPSRPVTSPPPRPMTAPRPPSINTHKRTPSIPAVSPDLPPLSPVYSTRPVVPRPTSSIDATMTNMAKPPKIPKVPTAASATSTTPAPTAPPRPSSTQESHPPIPKRSMPSPPAPAQPSSDDIQRIIDAEIDKLRQDQFVAWYECLVKPFIKTPHSQPTRCGYATIKRPPKPFEWMEVRKDETVPERDFHPKKRPRIDEEETENINVSCHILDQSEAIEATGLEIDELSSPETIYYDAPARVDTLLNTLEQVFGMTSWVTNQYESVCSALENEDIFTVLPAGKWRNVCYQLPALKSCAATVVLMPQLAYVEYFSIPALFFLNQPTLTVAGTVSADDLLVKIKEARLLYITYMDFHRHKSLFKEISQQGQIVRFVLDDAHFLSQWHEQGHVRYAKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQC6</accession>
    <name>A0A367JQC6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000878">
        <property type="protein sequence ID" value="RCH92085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQC6"/>
    <dbReference type="STRING" id="86630.A0A367JQC6"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="307" mass="34014" checksum="66A9E5AFAC91D817" modified="2018-11-07" version="1">MSPPVTNAESSSQGTPSAHTQRTAIFLRSSRKIILTGSETEEEAKAAENVPIKLPKQITFDDVHTQRVHMKQKLAAGFRLLAKFGWDEGVAGHMTLRDPEYPDLFWVNAFGQYFGHIKASDLVLVDHSGAIVRGNRTVNKAAFVIHEAVHRARSDVICAVHTHSMYGKTFSTFGRKLLPISQDSCAFYNTHGVYDDFGGIVYDKEEGQRLVNAMGPTNKALILKNHGILTVGKTVDEAIWWFVCMERCCQSQLLAEAASPDGYKGLSLISDQVAEQTAKVLGDSLTGYAMFQPMYEMIIKEQPDCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQD3</accession>
    <name>A0A367JQD3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000871">
        <property type="protein sequence ID" value="RCH92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQD3"/>
    <dbReference type="OrthoDB" id="2288994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="191" mass="22060" checksum="5DCBD0B40EAD0EFA" modified="2018-11-07" version="1">MLGSTASEEWILWYDYLSVNGLLRNKRSKSVHGSESILERRHFMSFSEDLWAKLTAKYISRFKALPTVVDVSLVDKWAYIINMYNQLNGVCKAKKHLNHLKNQDNLEDTIEKVFDFFEEILILVESKEFMLNTTNFSKVSEEDYVYQIWLPLFSKLFNINKSIVGIKTAIKISLNVVPNSTLAALDVVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQF0</accession>
    <name>A0A367JQF0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_011829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000867">
        <property type="protein sequence ID" value="RCH92173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQF0"/>
    <dbReference type="STRING" id="86630.A0A367JQF0"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="362"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH92173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="719" mass="82383" checksum="8022338652606C1A" modified="2018-11-07" version="1">MYFNQPQQQSRPFVYIQYPAPSSTKKTIDNHELRTDSSSSSSTTTTNTTTITIEQPKKKKRQHVGYACDNNQALRLDNVSLRQRLGELESKVDWLTSFVTNLEQDYRTTIPKLMSHVQPQEQQQQQQIVNGHSVEEWAIQTGWPVVEHINGMKSIYTNIKSFEDLSEAIKNTMQLIYNLKGAPILCRPSSISTDDDSVTSGSTVSSAKEHSFGFFESLGRLPTHGSKITLRNDDGSISSKMMAQPTISDKHLEVDVMTRLIHQHHKCAFPTLVSPSRFENHYRQGQLKPLVLSSVFSHSVPHTSIYHPHLTQIKDFRELGVKFYNHSHDLLGVDDEPANLSNIHQRTFLITYDLDHGRVRRAFLHIGIAIRMCFMLNLHRPEGYVSCKTPFEREQSKRIFWTVWFYDNMVSQLFHDQVAAMKLSQISIDLPAILPEFNQLERDQTIFTIQLIQIRKLAGSISEDLPRLEPHKLVKKYKCKLRTFYHELPSHLRFGKEANVLPPSTSLWERRTYYCILLDYCQAWITIYRALLPSSSATRTSSLENEAILHTSQAAVAAVKLFQAWFQSSALSSEGFDCFFRPYLYHFLSAKKILCANVAHIGRSPSLVYISRAYLVLLLQLYQTTPTRRSFDESAVENDLLQFLTEHHISMNEVPYQEMVDEALRDDPNADGGWSIFSYVPSPVMDDEDESKSRASSSSTASYGSDHPIIMTELAMDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR80</accession>
    <name>A0A367JR80_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000825">
        <property type="protein sequence ID" value="RCH92453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR80"/>
    <dbReference type="OrthoDB" id="10379398at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="10262" checksum="0C037C7C7EF7D815" modified="2018-11-07" version="1">MTRRHLIHRLSRLFRDDGYLRKKKEKPSEKIEIESCSSCTLSTHHASSTSTSIFEDEPHPKLCLAEQVKAILSGAIELADQELEEEDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS99</accession>
    <name>A0A367JS99_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000775">
        <property type="protein sequence ID" value="RCH92820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS99"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="22068" checksum="AD982CFD78932E11" modified="2018-11-07" version="1">MSSPAEEPLKEQVVKGEIDSLETKARYLGYLGRLRTALVASSRYLAYTSDVGEAFRPIAHPAIVTAAYGISWAYLGLDVGYEGYKAHHAGEDNAAIATTVVKRGVFQSLASMAFPMLTIHSVVKYSAYGFKNVKSPKIKAWGPTVLGLGVIPFLPFIFDEPIEHIVDKVFKPIEDKFARGQVARLGHNKAGDDLPAETKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSN6</accession>
    <name>A0A367JSN6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_011174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000758">
        <property type="protein sequence ID" value="RCH92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSN6"/>
    <dbReference type="STRING" id="86630.A0A367JSN6"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="293" mass="33410" checksum="9FB0B1600FE52D3E" modified="2018-11-07" version="1">MNSTLYPSTNVLSAFSSPDQHQGYFTSLHQLDSSLLDFFPDTKMDSNFYPSPCDSPMGNEMGLLTPTSSEFPTFNVAGGFDSQMLMVPPLEQFKPMEKPMEIKLPDIDYLDQFIAQHEAALYCPELEEDKAWPQVSRCTSPEPLSDEPTEVIILQDKKSNRITKAPGRRGRTKGVKNKPKTVEAKSETEEAKPKPKRGPLEGVLYVCQHDGCGRSFTRPYNLTSHMRTHTSERPYACSHCGRRFARQHDRNRHEKLHWGIRPYACHHCHKSFARMDALNRHLRMENGCTAIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSP7</accession>
    <name>A0A367JSP7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000790">
        <property type="protein sequence ID" value="RCH92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSP7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="71" mass="7731" checksum="C6920D273DAE6AEE" modified="2018-11-07" version="1">MASSPMFSQIPLSTDPAALKGAVDLMTFILKGLPFSQAVNGPSNNVAFMAIKEFIYMMSQNISKLYNLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT06</accession>
    <name>A0A367JT06_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000741">
        <property type="protein sequence ID" value="RCH93102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT06"/>
    <dbReference type="STRING" id="86630.A0A367JT06"/>
    <dbReference type="OrthoDB" id="2289379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH93102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="262" mass="29847" checksum="84EC36275D132F17" modified="2018-11-07" version="1" fragment="single">TQFHFEVVFLKFEKPFKVKSEQIDYGSGTQKLRLQLQRAKKANSQRISSVENAASRKSIKKGESVARLEEWYQQTVSHREQLRNFYYSPTRVRQKRTYELQRRRYIDKLCSNEHRYVKGSDKSQHIMFVGDRGYCVGSTIKGHLKYGGQWKPRKNSLYTLVCITNEHNTSQACLFCFKKPQSPLRITGNTKLKVVNGSFQSVNPDCPSVLAGKATHARDSLSAMAIGLSGIATLLFGATFPQFDPKRSPSKTAEFEHLAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU00</accession>
    <name>A0A367JU00_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, 38 vacuolar alpha mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AMS1_5</name>
        <name evidence="3" type="ORF">CU097_007332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000701">
        <property type="protein sequence ID" value="RCH93407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU00"/>
    <dbReference type="STRING" id="86630.A0A367JU00"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mannosidase Ams1-like N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 N-terminal" evidence="1">
        <location>
            <begin position="273"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="41453" checksum="B31EB08AAB9AFBEF" modified="2018-11-07" version="1">MTIYGHRHCHHASNDLKPPLDNAPSVPTNIAHSRLNNFLAGAGQFYSMGIHNRLWILRHSGAPHVQLKVYSVPDVKDAITQKFQEFTIGQHDFGPSWTTHWFQVTVKIPEALDGHEVTLQWDMGCEGLVWSHDGVPLQGLTGGSDQARHEFIISKKAKANEVYLFYIEAACNGMFGVGASDSMVADPNRYFKLKQADLVVANKPVQDLYHDLTILRGIAFDTDSNSIQARKALWVANEVINNFIGDDETAISECNRLTRDFLTEQNGSEMHRVTAIGNCHIDTAWLWPYDETKRKVARSWSSQLNLMERYPDYVFTASQAQQYEWLQELYPKLFEKIKIAEKNEQWEIIGGSWVEHGKSLKCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV18</accession>
    <name>A0A367JV18_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000660">
        <property type="protein sequence ID" value="RCH93745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JV18"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="9">
        <location>
            <begin position="608"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="8">
        <location>
            <begin position="1494"/>
            <end position="1696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2021" mass="227196" checksum="1ED22EEE9FC6F8A9" modified="2018-11-07" version="1">MVESDRSQKFAGTYRKLFDTIERGVEQCSTDLLQTLLEEKYDQLKLGIDAFTAASAQSRSKLTTGTIVSINGKSITFDQKEKDLVLKISDIINLNELQCAALWHSYKTDNHEYVDQQNSVDIPLHENTELIMNIANFYFEERISLLECIQSLQRISSDSEHPFNNIASSMVEKLFEDSTNNIPFVNKLLLQFSKLIRSQVPTRTYSFPGWSTAWAKQNIKEQKALLEILFLFTITTSLSPDFVVSVVQEFEVNNFGRFQVCSYALDTEGERIREQVSCISILIVVSMIIPPYLTLDVKLDPAAADASLIDSPNAVAKINQIVLHMGNSPEHSAFLLAWSYFLTCLRNAVDAAPSLPSGYDQVKLLLEGKQQVSFSVLADRSFARAAGFDAAEERTISIQQSDHLERTLVGRALKLNVFDTINAILESNLCDEDDVNSVGYRVVIRLLLKSFLATTLPQFLPMESYSSLINCFTLLYRDQPMPCQDFWNEDVDQQNQYPLLTAALGRFPVYFTHLTDMLASLATTNELDTRIDEKPVDKVYEFMCALPTITVVLKDTIFTSAAVENDVPVVQVDQNLQITPSLNYITGISIPRQSRGILLSNTQDSRIVQFAHGCSGWHMLVSILANSMQQTKPAATVDVTDEDYTLVGENPEAIISILNLIYRVLSNSPKLGPTLVDHVQKTAAVPGRVYEVPILISILCDILSFSSGIQQCPISIATLAIKCLTMLLPYYRQYIWPYLQKSPLLPRITPIPGTGSMIKLPFITSRALNIQQIIAKFECTLGSYELLLSFLDLVHGLVHDIQSNWWVREAAVNLSPDAQAQMETLYVCLHYLMLEVFPSYSGWRYRKVSERYLIGIKLLSIFIVICNYFRESNQPSTSGLSLGRIRDGIFSNFLYDGGIYHVSPLLDVVSDGAVMANALYKSSHIKEAQRTEELTALTLVFIKILLQRRLEHINEGTNISESTLERLMLERTASGSCSDFLLRIAKHINYRHNIALPIQATYVLTLLCRTTSAWKTVPSFVQYLGDTAEAHTIIRAYLETAKDDSQNETLLSAIWHLISTLLETQPSLAILFLDCGDFIMPSPKSAVRQLGGQTLTQTTTVSNTESAIRAAISMLEKWSSLSLEKPSVVSNVLRFLSTFWQTAFDHYALVENTRSDSALWDVIGKILLNPSMEVDTSADILESVDFLETDFGENDHFDLSVRQLCCSNLSKAFALRVIAYEIHLTAGNEKSKNGNLSKILEALPGGLKALLIKLSEPTRLSQMRQEYIKNGFDSSLTDSVHHSAGVLLRTIGIENTSALLFKSAVIGTGDDGAPGDIRQYGDSYLYNLRMTVSRVFPLYSDIKEKYNLADRDNMLITPKINAALEVERLSDGLLRKIIEANHNYSVVDSQLILFRSFKSFIETCSHHASVLIWVEKNNIDSFDNLHGFLSELIVQAKSEQRQDGVTLTSYSMLVHLIRNLIEDWIYLSKPTLSGTDDSAKQKYSSQVSQLLISLSDLLTRENLAYKDSVSDKTAVYFHRPLLEAVMLCIFTLRGTMESVNKNFLKSVEMQTCLGDVLSVVCDSFHVLSIKALSYSAEGSTASEEDVNRCIKDITIVTSLLQELVHERYGILQEAWVFKFKAHHTIDNLLKLFYGGIDIMLNEIDSLNITPYAEIALYFLLTLANIPKAAEVLVTYHVFDTLTNNRLTTRLQQGTLDLFIRFGDKTKKEPGYVERNPLHSIWCQILAVVSSLLRTNGKSDIVLKSTVNLLQICGPQIGKAFEKANSSSDSLFALAPLESLSMPLLEELERINSVFFELSKHLERIPNIATNLFTSYKDCSLLLLQRYLYYFTHPSHMKAQLYRTDNTETTDHFMQKTLRSILTITHHMMTSLVVLSSSELVLTAPDIEWPFGNIIIYPNMRASTDAEASFGTLVECINASIVMINQWQDAKDEPLEQALDVIQSCSLMLTSQAALWVAKPDLSDEVRMGIAVDNIMDIVETLSKAATTMEKLVEKKIVGDIRLRIKLIYMLQTFLSERFFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVI9</accession>
    <name>A0A367JVI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000640">
        <property type="protein sequence ID" value="RCH93918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVI9"/>
    <dbReference type="STRING" id="86630.A0A367JVI9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="440" mass="47635" checksum="F78A8DA8DD5A4242" modified="2018-11-07" version="1">MTTANKSDSMQYNKPSVINKTTVGDSQTMTRMHPSMKRPRAPIACYRCHHKKVRCDGIHPNCTRCLSTGILCAYPSSRRSRNTQPTNVDPFINNLSQLEAKIRRIETDLESQRNLVRSICGESNEVDKTSASTLTSRIIKTEKDLQESRSIVAQLRLRGEQRAARGRRAAAAAAAGSVSTSSGHDKNASSCSGRNNKMDHNAVSSTGRTKSSPILSKKKSNQATSNATMPVMTNNFNDSSSFYLASSSPSSSVDFMSPSSNYYFPSYTNDICVPYSNNSFQDWSLLNNLPRTLDSNNNTTNGFVDPMIIAAAENSITPLLSVYVDDPSMMTARARALSHLPPSPEQSRENSILVPGLQPSLSSTSTSSSNSSFGLVNESNNALYDDSYTQFMSNNEIMMMDQMTAAAAAAAIASNTNTNTTTTNTATTTTTATTATTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVK7</accession>
    <name>A0A367JVK7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 14C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM14C_2</name>
        <name evidence="7" type="ORF">CU097_014034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000629">
        <property type="protein sequence ID" value="RCH94014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVK7"/>
    <dbReference type="STRING" id="86630.A0A367JVK7"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1740:FF:000002">
        <property type="entry name" value="Transmembrane protein 14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="100" mass="10495" checksum="2CEC7AA645224845" modified="2018-11-07" version="1">MTDIIGYAYGATVFAGGLVGYLKAGSTASLLAGAIFGALAALGAYQVSQDPRNVTLALIVSLLLFIVMGSRFYKGRKFMPAGLVTLLSILMVIRYASKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWF8</accession>
    <name>A0A367JWF8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000589">
        <property type="protein sequence ID" value="RCH94332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWF8"/>
    <dbReference type="STRING" id="86630.A0A367JWF8"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="195"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="422" mass="46670" checksum="6199C2A91AEAF0D5" modified="2018-11-07" version="1">MIFSKVFKPNPIQTFEVNICSGVENNAIAFGPGSIINGNVKLFLDKPVKAKYIKILFTCQEKKDSVTLFSVESNIWNSKQDEGEGRTDDINKYLYSSMSTVLESGAHLYLFAIQLPSNVNYPPTIRDDSLGHRIEYSLQGFIYLSDQTSKSTNCLPLTYLPLVAVKTNAASENKTVKIERGDEFVLVTATLVNPYLCPGDFCRIKLETQNKSSQAINQVTIQLISTTTSLKNNTAPIASTGPSYHHKRHEILSESQYVSIPKHTQQNNSLTTSICTIQIPSTCVPTTQTHFASKYIDIQYEIIIFIPAFGHYSLNDTKFIATHPNCIRLPLVITTVPSTIPTLQIPFAVDSNNDDSLPTFIPYIESPSPSPTSPIYQQWGPGSPVEPSDEDYLYPSSPIEDASGHLMVPSTSPTRSLSIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXK8</accession>
    <name>A0A367JXK8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000557">
        <property type="protein sequence ID" value="RCH94625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXK8"/>
    <dbReference type="STRING" id="86630.A0A367JXK8"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="659" mass="75947" checksum="3B4E07C083F0E05E" modified="2018-11-07" version="1">MSDTTVPIFHTTNTITDTIGTTDAAAVHYQEFVFAATETMTDDVENTSPLKPWMFQGMNVAELFIKFQQAVIKKTTNQLFFIESSVHELLSLSNILFLCTSQHSPLCMDMFSEDILVELNKEMLVECMDFKQDMCDDACMKLTRFMNNMDSKSQSKDDVEIDLLVLGRSLSPLQGSLLRGITAAQQSLYQQDYNEKDNRTVKDDIIPVAMPDPFELHKPDSTEKFITYLPHSGFHNQRISLENAFLLASYLNRTLLLPPVYLASPAFPWLRFDKMYERILLQTKNGIEYCGQLREGEPLPPECLNYSHWTSVPWTFFYDFEGISKKIRVIFRNDMSLEWIRDELSSDIYFIKDNSPFDYRIYDLPESQTPLQRFVHRLELDALEAIKAKVIHFGSLFGSYRVLAQSEEHKDLLTWVRRNMVFQNPVLLQTASRIINQLGGVKQFVGIHFRVGDGLFKVRASIHVDDIYHQLVNEYTDLTVDEVAQYDTRHDDDRKEDTNYEVKQLRDTPVLEAAQQPIQVTHPPDTILQARLGTSTKHHLKCQSSDGRNNQFAKTTIYIATDCPNPREHPLLQKIFKTFPCVFVLSDFKSDLKELAKIKVAEDNVHLESYLIPMIDAIIAAQGFDFYGTNSSTFSTYIERQLHPMYTNEPIKLFDAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY53</accession>
    <name>A0A367JY53_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000532">
        <property type="protein sequence ID" value="RCH94860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY53"/>
    <dbReference type="STRING" id="86630.A0A367JY53"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="598" mass="65757" checksum="88E94BA1058D0B0F" modified="2018-11-07" version="1">MMSDNESGIKRATEQDEQLEALKKQKLDEPEEKKPVQTDGVVAVNNTDTLGQTQPNSSDDTAITSEQLLFALTSVPAETKVSPNPVIEKTPEEKLSETTTAKTTSNEQKTPPMISVTEADKNASSVTTSKETHDENKPAEPLRPSTSFSPSLSHATSLALNNLPNISAALRRLSNAGVIEQLSSSSSRSTHTGQERKKSIEVTPSEILGNALAVVAASARAANNNSTQTSSIYNNNNSSGGNSNSNNNSNTAAAIGNLAAITANISNFLNSSGFHRGSFSQEDTQKLAAAVASVTNNNNNSNSSSHNTARRNSSIAAVGNAFSNMIDQAMMIRRNKSMSAGTLVQQEPLPKPKLIVKNDQVWKALEGMEEKLLGCQVYSPHRLLPNLENCLNGIMEVRVPARYLTFENVQVKKRAIWGTDIYTDDSDIVAMVIHSGKYEPQYKEPEIEPNDPFALAIAGKPREATEAAKKLALSGKKWIRQDALIPDHDLKVTVRVLPRLQSYTGSIRHRIKSRDWKKHDGMSLYVNKVEKIKKGDARLKGRAAIKSRMFAYEPYRKKALGLDVMNKEQEKKMPEERPLQRGRVKKTHRVMRMFQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY59</accession>
    <name>A0A367JY59_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HRK1_4</name>
        <name evidence="12" type="ORF">CU097_012416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000532">
        <property type="protein sequence ID" value="RCH94858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY59"/>
    <dbReference type="STRING" id="86630.A0A367JY59"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="198"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="523" mass="59801" checksum="1067BED7F4B0084B" modified="2018-11-07" version="1">MLHLVNQRFDIVTPERSRPSSPSLSPAVVTHTVATSQPQRRSWEASSVDLNELSRLLQQNPRPRPRSQLFQSSKPPSPTLSTNSAEPTFCSNTSKNAVVPILSQQQRRPSLIHRPSSTCSTPSQFVFKKPEYDEKYHQTHFHRPCSQERSKDPFLAWSDLKRFFVQQQPTSPTGSSTHSHESETFANQFRQDISGRYGTWGKYIGKGAGGSVRLIRRSSDQKTFAVKQFRKRLPHESEKDYIKKVTAEFCIGSTLHHPNVIETLDIIQEGPNFYEIMEYAPNDLFNIVMSGMMSREEIACCWRQLLNGVDYLQSMGIAHRDIKLDNLVLDHMGILKIIDFGCSTVYKYPFESNMTLTKGIFGSDPYIAPEQYTQPTYDPRLSDIWSCGIVYICMIIRRFPWRVPRQTDPSFRAFATNHNQQQIRLLKLLPREARPVMAGILEIDPNKRLNLQAVLADNWVKEIDVCQVHEPGKHHVHHVLVSSPPNLNRDNLVVITPEPPGVVAEKEKRKRQQSSRPASPIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYL9</accession>
    <name>A0A367JYL9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000516">
        <property type="protein sequence ID" value="RCH94989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYL9"/>
    <dbReference type="STRING" id="86630.A0A367JYL9"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26581" checksum="29C92796717001B2" modified="2018-11-07" version="1">MNIAEYPTNQLIQIVSRLIESLLESNQHLPDKKITYFHSRTIPNITIQSYLSRIHKFAPFDNEALISMLIYFDRVHKLNKGFHINAFNIHRLVIASIVVAVKFTSDVFYSNARYAKVGGLPLKELNQLEVEFLFFADFQLHITLNDLQEYANQLLSHAVHQQSTTVATYQIVPSPTHTPSTSPKTTTTTTTAVSLPLTPPYSNKSSLKRHHPYQRSNHHTSKKLGLISPKDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZL3</accession>
    <name>A0A367JZL3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pseudouridine-5'-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HDHD1_2</name>
        <name evidence="5" type="ORF">CU097_014211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000471">
        <property type="protein sequence ID" value="RCH95404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZL3"/>
    <dbReference type="STRING" id="86630.A0A367JZL3"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="230" mass="25928" checksum="F598A898C8788E12" modified="2018-11-07" version="1">MTRITHCIFDMDGLLLDTERVYTEVTQQILDKYANGVKFTWDVKSKLMGKTGDESAAMVVKTYNLPMTTEEYLKITSIIQEDLFPHAKVLPGVERLIRHLHAHKIPMAVATSSTRSKFELKTSLNKELFEMFDVIICGDDAEIKNGKPAPDLFLAAQRRLGNPPAENCLVFEDAINGVQAAINAKMNVVWIPDENIRKLADDEHGATIVLDSMEDFIPELFFLPAFEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZZ7</accession>
    <name>A0A367JZZ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_010267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000456">
        <property type="protein sequence ID" value="RCH95534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZZ7"/>
    <dbReference type="STRING" id="86630.A0A367JZZ7"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="8">
        <location>
            <begin position="114"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="TRAFD1/XAF1 zinc finger" evidence="7">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="6">
        <location>
            <begin position="538"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH95534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="659" mass="75500" checksum="7448B537BEA050C8" modified="2018-11-07" version="1">MQDQQQQHQQQQQQQDIVWKSYYFVRQAQPELEHGDKIILPATALTQLLSKAGSEQLPSPLTFELRHPHTNATIHCGVKEFSSSDTAELPLWILSALGLKEGDRVLIQLRLLPKGTWTKLKPLSIDYKEITDYRAALEAHLRGHYNTLTTGQVLSCRYGGRTYQFKVVELKPKDAVSITDTDLEVDIEAAEEQQQQEKNWHPTSEPVVIRLNESQSNVEVPYKSYRYWTVKIPQSISVKLVLNIEAGDIDVVVSSQEKKPTVDRFEWASLSSDSERTIRIDNAPSDTLYVGLHGYKEYSIVSWRVEEDDGSMEVDDNVNEKPESTENKVQCKNCHAWILERTVLLHEGFCYRNNVPCPWGCGKVFKKGSEELEKHWHCDQCEHTGTTDDKDKHIEYYHTPKTCVCDTFTSNTYDALAKHKSTDCPEKMIVCRYCHTLTAQGVVSLDARDRLLGLRSHESYCGSRTITCQKCNKPIPIKDIQVHAKIHEVKRQQQTLPPACCNQNCTRPRAKNRLSLCQFCFGPFWISEDDPKNAKLMQKVARKLHSQLTVGCGNSYCRNKYCATCTKDPKDATTAASMLIPLIKNLPKELVKSDPQPELYFCVDESTTRKKFLAEILCDMTEHKFELGWCVKALESEQEDLDRAQTWLDRNAPRKNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0D7</accession>
    <name>A0A367K0D7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000449">
        <property type="protein sequence ID" value="RCH95605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0D7"/>
    <dbReference type="STRING" id="86630.A0A367K0D7"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="187" mass="20832" checksum="7D59E320C405BABA" modified="2018-11-07" version="1">MHSVYTAGIDLKRHHVKNSNRSAPKSDNVYLALLVKLYRFLARRTDAKFNKVVLKRLFMSRVNRPPVSLSRVVRSAKSNSTVVIVGTVTDDSRLLEVPKISVAALHFTKTAKARILKAGGECLTLDQLALRAPTGANTVLIRGAKNAREAAKHFGFGPHKNKKPYVRSEGRKFERARGKRSSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0N9</accession>
    <name>A0A367K0N9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_014069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000439">
        <property type="protein sequence ID" value="RCH95709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0N9"/>
    <dbReference type="STRING" id="86630.A0A367K0N9"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="329" mass="35563" checksum="575AC23F96CFC2F4" modified="2018-11-07" version="1">MPPSSLINRKLSSAPPSTTSAAEIPLSYPAAIRGCEPCKRRKRVCNGQKPCMPCVEGSQECVYSVVSDHPRSVFSTSTARRLSSGSACETCRRRKTKCDGCNPCGFCASSGIECINNNNTVERKKRQAAAAVAAAAQSNPDDNNEAMDRIEDRLRRIERLMTAFTPSPLSKNCTTSGYYRKLSSPLFSAQKPQRPHRHHSIQGISSSEPPKDSFSAGNNLSSSPPPPPPLSPRTLRQSASQLTNQSMYLSPSSSSSTTSTTTPSPNMQSSTSTPTSNNESSWTQPTPIPSLMDQLSKLTFVSTAMDYTAVQYPIYPITPPPIPRPSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K164</accession>
    <name>A0A367K164_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006758</name>
        <name evidence="3" type="ORF">CU097_008717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002722">
        <property type="protein sequence ID" value="RCH83259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000413">
        <property type="protein sequence ID" value="RCH95982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K164"/>
    <dbReference type="STRING" id="86630.A0A367K164"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="246" mass="27618" checksum="160D4F169269CFDE" modified="2018-11-07" version="1">MSSTLATQASERKISRKLSVNVNQHTVNVRPIIKGAFKEAANSLTEAYYGNQIMGWCVRGLDQRKYEEFLYTLFKHMIDVSSLQSRDFALQVEGCKGVLLWTNNPNGNSWPRVLNTLKLARLIGLSAAIRAVTQVSPSCEKMKRKVMANHKQFITIGYVGILPHEQRKGYGSALVQHVLDKADEAKHPVYVEAPDTASVKFFENFGFKVQATAFIADYPVALMVRMPIHLGSPEPLRVRPGRRNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K176</accession>
    <name>A0A367K176_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000446">
        <property type="protein sequence ID" value="RCH95641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K176"/>
    <dbReference type="STRING" id="86630.A0A367K176"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002696">
        <property type="entry name" value="PRK02487.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="18343" checksum="2EB8660687852D4D" modified="2018-11-07" version="1">MTTPLKELLEIILLQEEKCQFDSFTSQDALDLGLLLIENAKPFKRPVVVDITLNGHQLFHYAMQGTNKDNDEWVRRKSNTVNRFNHSSYYVGRHLANQGKTLEEKYFVNEKDYATHGGSFPLTIKNVGVVGTITVSGLAQEDDHNLVANSIQEFLAFREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1I9</accession>
    <name>A0A367K1I9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000407">
        <property type="protein sequence ID" value="RCH96040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1I9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="8868" checksum="C40FA98813C21285" modified="2018-11-07" version="1">MPYRIQLELAYPNSQDLDALEISGITMHDITVDKYTLIFVPSLFIVGDNVRHAEFCLSKVSHAVVPVAIAFGKLILSHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2N6</accession>
    <name>A0A367K2N6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000370">
        <property type="protein sequence ID" value="RCH96427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2N6"/>
    <dbReference type="STRING" id="86630.A0A367K2N6"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="39997" checksum="FEF4F57827F22481" modified="2018-11-07" version="1">MKNLSSDTVIKLNIGGVPYYTYFDTLKRSSYFINLLNGEMEQKTLVNGDEIFIDRSGQLFGHILEFLRTGSLGSVEDDIKMLCKIREEAEYYQLDELIETIDGLTEGISVIEHTMPVGSKGQQENMARVFMDAIGEQATLKLAFATQMRVDLYNTVIECNGRIKGVQRIEGLHKQIGLGSQIQWPLLLRQLAASMPFASLYIVEAMRNKGLDVNILKKDTSSSLPVELQTTEAASLPLGARTRKAHLAFAEKRCRGYFDIEYYRQQMAMAFKFQNNMHIKNILAQIERTIVLNDQEKQATLNPFIPELSQSTIDMLPDFLHNMIRSNNNTTNSTDTNNNNNNTMEDHLCIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2Q8</accession>
    <name>A0A367K2Q8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000368">
        <property type="protein sequence ID" value="RCH96446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2Q8"/>
    <dbReference type="OrthoDB" id="2282120at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13168" checksum="5D202EAFFA5CBFB8" modified="2018-11-07" version="1">MIFSAKLSNGQEYEIGNEEVKAPSVTKSIVNATRVRVPETAKRQLHKRMRISSAPNTLVTFGILIHGFSFEVYIVRHANDYYPYEKITWGELPRFSKVDDVLMHALRSMLTLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2Y3</accession>
    <name>A0A367K2Y3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000360">
        <property type="protein sequence ID" value="RCH96520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2Y3"/>
    <dbReference type="STRING" id="86630.A0A367K2Y3"/>
    <dbReference type="OrthoDB" id="2276119at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="595" mass="67365" checksum="831E86723798EA25" modified="2018-11-07" version="1">MVILSEPLFSTQDNNGPVYPIVSHSKEELQNILDEEAQLKRELSKMTIDISKSLSLIPIMHGMFNIFKEPQEIEIENEGTNEQENDNTLQLISTGSLSILDVSNQLKLTAPVLQVNVPEYRAKRRKVEHILSGLLNPSTEHTSEKEVTPTMTDDGLEEDAQLTTAPSSPIQQTHKPKGNDWYSGTEPETGVQVYEYPARMVPVFATPGQIEKVAEITESAKQNNRFIGTDFRKAIDYLNFTLTDYDASIEDAWNVSGKLIFIKDFLNNLADKDMTIVILTESLGEESSMYELIREYLNFACTRVGNVLDDDWNGEYGVFVKTRKSEEILKASEQQLFTREADLVICLDILVEDNIESLSLVNNINQKKRPHIVWLVTVGSLEERIFRLMDEKKITFSQCNSQLSELSMAANNWPQGSLEDGMTRNMLAALNLTSWLVDYKGECEYQYRSKIELPNSLLRTTPETSAVAGSVVTTTTTTTIVADEEASDMELSSDIDTEEANRQLNAEDTRPVLSSQLLNFLENSIFPTCDFIVNKKTTPEGLDSDDVELATTILHTTGSSYIDELKILKLEFEQKFNTIRKKYLEETKQRFFKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2Z4</accession>
    <name>A0A367K2Z4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000360">
        <property type="protein sequence ID" value="RCH96519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2Z4"/>
    <dbReference type="STRING" id="86630.A0A367K2Z4"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="592" mass="66781" checksum="198FB155CF426346" modified="2018-11-07" version="1">MSNIKVLVTGSTNGQFRELFAKAQQINEKYGPFDMHLCVGNFFAPNTADEVIEDLINNKIEVPLSTYFLMGETPFPPSVQQHIDSTDGEVCSNLYYLGNRGILTTSQGIKIAFLSGVQPKEEQEDNKDNDTHYTKDMVDKLCQTKLPAALPPGVDILMTCEWPKNIKELSAVSVDMDDSKASLYVSQVAAALKPRYHFAASQSVFYEREPYKNIVSGLGGRDERLAKHATKFIGLGDAFNTEKQRWFYAFNLVPMSQAPSEALETVPENTTECPFSSLFTNKRRHEDDHNGAFFWGEEPKRPKMGAEVPKGNYVCRRCNVPGHYIQDCPMSAPKQPPEGYVCNICKEPGHFIAQCPQRQQRPPPGEQPSLDSCWFCLSNPKAEKHLVLSIGDELYAASAKGPLLSSRDNECRVPGTGHVLIIPVTHYPTFGKIPLDSQVEVIAELEKYKSALRRMFEKYGHDMITFEISRESFRGMSHAHVQVIAIPKGKCDLVEQVAREQGQAFGMDFIEQLPDNPTIPYFKLELPDGRVLVHVIKPKERFNLQFGRLVVSHVLGKPEREDWKACQQTEEEEKKESDLFKAAFKPFDFTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3M3</accession>
    <name>A0A367K3M3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000365">
        <property type="protein sequence ID" value="RCH96471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3M3"/>
    <dbReference type="STRING" id="86630.A0A367K3M3"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="476" mass="52543" checksum="6C0A43883489B939" modified="2018-11-07" version="1">MIKETLDNPKFMQLPDELQIKILAELPIQDLLKSTVVCRKWNQLVFDGSLWTKLNVAPFYKTIPIDYLLKLIKASSGFLKTANFRGCIQFNGHALRTLSDHCPNVQVLIIKDCRGLSSASITYFLQRAHQLRVLDVSGLDTVKNSTLAVAGSCLDKLEKLNLSWCRNITGHGILPIITSCSTHLRYLKLNGCPQLDDNTMELLGRHLPNLTYLSLAACTSLTDTGVLSFLSSGKGSSLLTHLNLSSCARLTDATLRHLSQYAVSLTHLELSGCVLMTDQGFCYLAPRLKTLVYLDLEDLQQITGITVRAIANNQPELKRLCLSNCTHISDDAITHLILHGVCHKLQHLELDNCAITDEVLNTIAVYLQQLKKALSESAILNASIDSNISLFSSTSPSRERQMNVEVLDCSNITESGVREAMAKAGSMLTIKSFYTFQNTTAVDSSLNRHSISGRGTRANHHRAATMSQTANNCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4V7</accession>
    <name>A0A367K4V7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000297">
        <property type="protein sequence ID" value="RCH97217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4V7"/>
    <dbReference type="STRING" id="86630.A0A367K4V7"/>
    <dbReference type="OrthoDB" id="10291696at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="510"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="614" mass="70538" checksum="386936CDAEAEED4E" modified="2018-11-07" version="1">MSKENHSKQCFMSVETDDDCHENTNHLFQYASTNNIVALDDEYNSEENDSERKGSYIDDSGVFHCDEDLEEEDCQQAFKSKEELYQKGPDLPPLKSFLKSTIESKNTLSQDKNDASIYTQLMSSLDMTTRKLHNEYPTSCFEDNRSEHKLSSSAPSGYDYLDEQHELQMLEVQKYFQLSASAPASQMANEDIIDEEYESISDMNDFCNDELVTTANESQTCSATIQGQQTVQSDENECDYQETTAVKDDNKELMDDSNLSWKELADRCYGQTDDKLSLSTVDPNNPFLEVYFERVRQREYPFSTSGPSYLYINPYYMPYQSCYTSMSTDYTPMEQPRNHGSFIMEVTNIAGAVKLKHLYDLFFDPSVLYHRDDYTAFVCYQSLDSLTAAVGQYYGRRFMGKKLHCCAYMRENFTTGTSLGTQTTECTMEPSSSTDSYVGNRSDAEKKSSKAHADKQKKHFSVTIHAENSSTTKQELIQDKPESKRKNRRGNKKSLASINVDCFWRPLRSSEYILATSNTTEDLIFAKATGYWSVDDFHVDFINTLFTSCKNVYLIFIPQQADYINGFGKITSKAQPIHSMNLKNTPFAVKKSEFQIVKEGRNWHNILKIRWINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K609</accession>
    <name>A0A367K609_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000266">
        <property type="protein sequence ID" value="RCH97569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K609"/>
    <dbReference type="STRING" id="86630.A0A367K609"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="209" mass="23801" checksum="C0CC85A9FD16F1A9" modified="2018-11-07" version="1">MIIEEADQDGDVFYDSTEYAPGEYEKLIEEATQFKSRGNQHFGQGEYKEAIEQYEHALVVCPLACTKERAVYFANIAACHMKLNEFKDAKDMCTQALKIDPNYTKALLRRAQASERIGTYASMSEALEDYKKLKTLAIDTYIFKECERAEKELPTKINFQMEKEKEEMLNKLKDVGNALLGKFGLSTDNFQFTKDPSGSGGYSVNFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K680</accession>
    <name>A0A367K680_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_004104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="PJQL01000284">
        <property type="protein sequence ID" value="RCH97351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K680"/>
    <dbReference type="STRING" id="86630.A0A367K680"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="444" mass="51129" checksum="F17EF9EB464027BE" modified="2018-11-07" version="1">MAMRKIAAVIGSSGIGKSKLAVELCKALNGQVINADALQVYKGLDIITNKMPVNEREGIKHHLMDFLNPEEEYSVTEFLKDCSQKIESISEQSQLPVVVGGTNYYIQSLIWNNTLIGQRENSPALDDFPELDKLETSELYERLSQVDPVMANKWHPSDRRKILRSLKIYHQTGQPQSEIIKLQKEQNETEGLQPRYRSLIFWIYAEPSKLNPRLDERVDQMIETGLFDEIKDLRNRVVQGSIKAPGQNEEKYQRGLWQAIGYKEFDPYFNALEEGKEESEIVKIKDECTERMKAATRRYAKRQIQWIRNKLLPTVMKSKGDDVLVYLLDANDLSNWNVNVKDTAITVAKAFQEDLPLPSATSLSVTAEAMLTPSEDAQDTQSRVLNWKKYVCDICKTDKGEPLQLNGDKEWEQHKKSRFHRKYVKHLKVEAMRKAYLESKKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6C7</accession>
    <name>A0A367K6C7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Accessory factor associated with RNA polymerase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_013096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000246">
        <property type="protein sequence ID" value="RCH97812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6C7"/>
    <dbReference type="STRING" id="86630.A0A367K6C7"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000002">
        <property type="entry name" value="protein CDC73 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032041">
        <property type="entry name" value="Cdc73_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16050">
        <property type="entry name" value="CDC73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paf1 complex subunit Cdc73 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="7">
        <location>
            <begin position="242"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH97812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45336" checksum="D2A3EAA9BF6CCA14" modified="2018-11-07" version="1">MSKDTLSLLRESTIHNKPVILLDASGNAVSNIIDAKSIKFSNDSVFPRDTPTNFKKIATSADSSTYTLDTLIFLVQTAQLDNSAYFKECQARQIENVAIVDRRKILDFLTGKVSQLPNITRPSSPEKRARDEGSTTETSTKKAKTAPLKSEDSIKAVKQVISREREIVTRSSILKGTKNFTHAINLAKQLVLGKEVPANGRPNTTSKPGASQTSSVNPSKNGTKPTTGVATATKNQKLSSKDKIPLIIVPAAPTAKFTLYNIKQFLEDQTYVDPQELRNEGLKKPDRVIVERKKPNGQSVPYHVVDSVAHFKQNDWDRVCCVFVTGKVWQFKGWKWEKPVDLFSNVKGFYPKWTSETIQPPISEWAVSEINIHRERRYMDRAAVSQFWDALDSYNATHKSYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6Q5</accession>
    <name>A0A367K6Q5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Translation factor guf1 mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GUF1</name>
        <name evidence="11" type="ORF">CU097_014391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000239">
        <property type="protein sequence ID" value="RCH97904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6Q5"/>
    <dbReference type="STRING" id="86630.A0A367K6Q5"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="58"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH97904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="657" mass="74068" checksum="67D2E9C03383DBBE" modified="2018-11-07" version="1">MSTGLLLRRLPSHFPTKVYNKSSILLSCHKRWNSKSTTEKLKSANPSKDIDLTHFPAENIRNFSIIAHIDHGKSTLADRLLEFTNTISKTGSNKQVLDKLKVERERGITVKAQTVSMFYQYKGKEYLLNLIDTPGHVDFSYEVSRSLAACQGTILLVDAAQGIQAQTVANFYLAFGEGLEIIPILNKIDLPGAEPERVKRQIQSAFELDTSSILQISAKSGINIDKVLPNVIEKVPPPIGDIEKPFRALLFDSWYDQYVGVVCMLGVKDGVIRKGDKIISAHSDTKYEVTEVGIMHPEQVPTGYLHAGQVGYVICGMKSASEAHIGDTFYHVGQKVDVLPGFQPAQSMVFAGIFPVDTNDFRKLDDNIRKLTLNDASVSVHKETSHALGQGWRLGFLGTLHMDVFRQRLENEYDANIIVTQPTVPYKVIYKDGTSKLVRNPSDFPDMDERSLRVSKFQEPMVLATLIFPDEYMGKLIELCGSRRGEQLEYTYVDETRVMMKYRLPLAEIVTDFYDELKSRSSGYASFDYEEAGYEDSDLVKMTVLLNSKPVDALSVILHRSQAEFVGRDWVKRLKDVIQKQLFEISIQTALGTRIIARETIPALRKNVTAKCYGGDVSRKMKLLQKQKEGKKRMKMIGNVELPQKAFYDFMDKSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8T9</accession>
    <name>A0A367K8T9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_014631</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000182">
        <property type="protein sequence ID" value="RCH98634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8T9"/>
    <dbReference type="STRING" id="86630.A0A367K8T9"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="423"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="594"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="768"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH98634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="931" mass="104541" checksum="D67F50730AAFF7A5" modified="2018-11-07" version="1">MSGNNIKVVCRFRPQNALEVREGGVPIIEIDEEGTQVTIKGETTSSFAFDKVFGMNTPQQDVFEYSIKSIVDDVTAGYNGTVFAYGQTGSGKTFTMMGADIDNPQTKGIIPRIVEQIFASINDAPSNLEFTVKVSYMEIYMEKVRDLFNPSNDNLAIHEDKTRGVYVKDLYEIYVANKDEVYQAMKNGSANRMVAYTHMNAESSRSHSIVVITITQKNLDTGAAKSGKLYLVDLAGSEKVGKTGASGQTLEEAKKINKSLTALGMVINSLTDGKSSHIPYRDSKLTRILQESLGGNSRTTLIINCSPSSFNEAETVSTLRFGMRAKTIKNKAKVNADLSPAELKALLKKAKTETMTFQTYIAALEGEVNVWRTGNTLPEEKWVSLDKINKGDYSALPPASGFKPSTPVDDASRPTTPSVVLEKDEREELLKRENELMDQIAEKETELANREKLLDSLKEEVNYYKEHEALITKENQQMSNELSELKLQLQKISFESRENAINVDSLKEANQELLNELEELRKNLQEVRMAYKDSADNDKEKKKADLIAQMMNKWDPSGEINQKERQIRESVNKLEAEGSLPLTVEETAALRRDLADSQILLEQHTKAIDTLQDEKQVLEKKKVELDERLKKLEQEYEELLDKTIAEEEATAKKNADIEVAISAVKTKLESQYASKKALQQEEIEKLKKEINSKGDNINNLSQALQSLKEATESLQKTLAEQTPTAPTAYSEREQEIERMRKAMAKDLADFESMKKALMRDLQLRCEKVVELEMSLDETREQYNNVLRASNNKAQQQKMAILERNLEQLKNVQKQLVEQNSSLKKEVGVAERKLIARNDRILSLEQLLQDAQEKLINQNHKFEGQLRAARERLQQASQQKQQAGQIVSSGRVAKPIRGGGAGAVVHQDESVPASPAEKNKRTSWISGIIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8V3</accession>
    <name>A0A367K8V3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CU097_012978</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000210">
        <property type="protein sequence ID" value="RCH98271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8V3"/>
    <dbReference type="STRING" id="86630.A0A367K8V3"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="19">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="18">
        <location>
            <begin position="152"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="20">
        <location>
            <begin position="293"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="17">
        <location>
            <begin position="505"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH98271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="699" mass="79414" checksum="E87E7A798D298F82" modified="2018-11-07" version="1">MSNFNNNIATKFPDLKPRAPSGEALLETERAKTSFDVKALSKFMYTEEWLDRMYKILNIIENDPAFDKTKRYYESRSEKIKSSLWKDRRMTELAREHNWDDQDLQIVNFLFDQSTPFSLHYGMFIPTLRTQTTEEQKKLFLEPALRNEIIGCYAQTELGHGSNVQGIETTATYIPETNEFELHSPTLTASKWWIGGLGKAANHAIVMARLITDGKDYGPHPFCVQIRSMKDHTPLKGVTVGDIGPKFGFNSVDNGFIMFDHYRIPHISFLAKYSQVQPGTGVYNKPPNAKLSYGTMVYVRANIVMGVRYALAKATTIAIRYSTIRQQFVDSVSPKKWDNKVVETPVLDYTMQQYRLLPIVAAAYACFFTGREMLRLYDLNQEAMQKGNFNLLADLHASSSGLKSLTTTMAVESIEDCRRACGGHGYSMFSGLGQFYQDYLPNVTWEGDNYILTQQTARYLLKTFRNVVAGKAEPSEHNHTINYLTQYLQNPNAKCPASKPSDFLNPELILSAFGYRAAYGIAKVAEKIDREGRSWNSMLVEINRISRAHCQYILVRNFIVTLQNDVTLTQPEYKPINNVLKTLAALFSLNTMEKELSEFLLSGYLSSEQCSMLKEQVISLLNAVRPDAVGLVDAFALPDYYLHSALGRYDGRVYETMTKMAELEPLNQTLVVDGYEENIKPFVHQRKAVNKDTAATSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8W1</accession>
    <name>A0A367K8W1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="21">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FAS2</name>
        <name evidence="21" type="ORF">CU097_001287</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000184">
        <property type="protein sequence ID" value="RCH98607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K8W1"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000168">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="1633"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="20">
        <location>
            <begin position="2522"/>
            <end position="3060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH98607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="3292" mass="364475" checksum="1DB26BBD6A40C550" modified="2018-11-07" version="1">MSRLLGKPPLMVAGMTPATVNEKFVSAVMNAGYHIELAGGGHFNETVLRDKVNKIMNLTRAGEGITLNIIFLNVRQWGFQYPLIQVMRKEGLPMEGLCVAAGVPSLELANEIIANLQAAGLRHIAFKPGSVDTIRQVIAIAAANPTMPIIMQWTGGRAGGHHSFEDVHQPILETYAAIRRQPNIVLVAGSGFGGADDTLPYITGDWSTKFDYPPMPFDGILFGSRMMVAKEGLASPAAKQAMVDAAGVDDADWEKTYKGPAGGIITVLSELGEPIHKVATRGVRLWKELDESIFSLPKEKRLPALLAKKDYIIKRLNADFQKVWFGQKKTGEAVDLQDMTYSEVVYRLIQLLYVKHEGRWIDVTLRDLVGHFLRRVEERFTKTEAPSMLQNYSQLDSPYPFVEEFMAQFPDAETQLLTSEDVLHFIALCKNPVMKPVPFIPVMDKDFDIWFKKDSLWQSEDLAAVVDQDVQRTCILHGPVAAKYATRVDQPVGEILGDIYESHIQSLKERYYKDTPIPQIEYLGGSAIQNSQVKETVSGNDRIYELTSSSIDESQWLQAIAGPKYSWLRALLTSSFIVQDKRFIDNPVKRVFRPRDGQRVVVSTDAQGNVTAVKVQDRRPWSATDKTKDYITSVDASISGKLINFNLYEKRGNDLIPFNLQFEYKPELGYAPIHEIMEGRNERIKDFYYKLWFGVDHKDDYLNVPVTEKLIGTGESVKSADVKEFCQVVGNQAEIFIDRGQKVVYAPMDFAIVVGWKAIIKAIFPKVIDGDLLKLVHMSNGYRLLDNSELLKVGDVVDTYAYINGIINTDSGKIVEVKGTIIRDGKPVLEVTSQFLYRGQFNDYEHTFERKSETPMEFKVKDVKDIAVLKSKEWMHWTDALEKHEVTVGCSLIFRLNSEVKYKNKKVYSSVKTWGTVGMQVSTKEFVEIAKVEYESGESHGNPVIEYLKRNAQEIEQAHFFENGGYSVMPSKSTYSSVVRAPSSNEPYASVSGDFNPIHVNPYFADLAQLPGTITHGMWTSASTRKFVEIFAADNVPRRVVAYDVKFVGMVLPSDRLETKLYHTGMKNGRKIIKVETFNQNNEKVVEGTAEVEQPVTAYVFTGQGSQEQGMGMALYDSSPVARKIWDEADKHFMENYGFSILEIVRNNPKEKVVHFGGLRGKKIRQNYMSMTYDTAEADGTIKTLPLFPTINERTAFYTFRSPTGLLFATQFTQPALTLMEKAAFEDMRSKELIQSNCAFAGHSLGEYAALASVGDVLPLTSLVDIVFYRGMTMQSAVKRDEEGRSNYGMAAINPSRVSKTFNDTALRFVVDAIAQRGDVLEIVNFNVENWQYVAAGALQNLDALTNVLNYIKTANIDIQKLMETMSLEDVKKHLDEIIDGVFEKTKAKLAKGRIVLERGYATVPLPGIDVPFHSSFLLSGVTPFRGFLAKKFDPSDIDVGQLTAKYIPNLTAKPFSTDKSYIEDVYKLTSSPRLAEVLENWSPEKYVTPAQQQHLGYILLIELLAYQFASPVRWIETQDQLFKNYQVERLIEVGPSPTLSGMAVRTLNLKYQAYDNALSNRRQNLSIAKDAKEIYYEFESAVEEEPEATPAPAASTPAPAPAAAAAPAPVAAPAPAPAAAAGPAAAVSDAPITATEVLHAVIAQKLKKSLDEVPMSKAIKDLVGGKSTLQNEILGDLQKEFTNAVPEKSEETPLDELGSALNNGFSGALGKHSSTLIAKMIGAKMPGGFTLNSAKSYLSNSYGLGSGRTDGALLVAITMEPASRLGSEAEAKAWLDSVAQAYAKKAGITLSAPGSGSAGAAGAATAVISSEELDALKAKQDALIYQQLNLYAKYLQKDLREGAKKYEQEKTTTAKLQAELDLWLAEHGDIYAEGIKPVFSALKARRYDSHWNWARQDALEMWYDIIFGKLAVVDREITAKCIRVMNRAYPQLLDFMRYNVEKCATDKGETYRLAKEFGQALIENCVDVLAENPVYKDVGFPTGPKTTVTEKGDINYAEVPRPGCRKLADYVRDMVAGSQMTELSERLKAQHGVGRMPFLHLKKKNPSEPSGWEFSNELTSSYLDVLREIAEKGITFVDKCVLLTGAGKDSIGSEVLKGLIAGGAKVIVTTSRFSPQVTKYFQSIYETYGSKGSELVVVPFNQGSKLDVDALVNYIYDPKGLNWDLDFIIPFAAIPENGREIDSIDSKSELAHRIMLTNLLRMLGNVKTHKQKIGSDTRPAQVILPLSPNHGTFGADGLYGESKISLETLFNRWYSESWSQYLLIAGAVIGWTRGTGLMSANNMVAEGIESLGTRTFSTVEMSFNILGLMHPSIVELCQTEPVWADLNGGLQFVHNLQEVNMKLRKEIRETAEIRRAIDAENALDFKVVFGEEAERKHKPHKITPRANMKFDFPKLKPYESLKHLSHLKGMLDLEQVIVVTGFGEVSPWGNARTRWEMEAYGEFSLEGCIEMAWIMGYIKHHNGNLKNGKFYSGWLDAKTGEPVEDKDIKSKYEKKILEHSGIRFIEPEVMHGYNPEKKMLMQEIVVDHDLEPFECSKEEAEHFKHQQGDKADVYETANGDWCVILRKGATLYVPKALRFDRLVAGQIPTGWDATRYGVPKDIVEQVDPVTLFNIVSTVEAFVSAGITDPYEFFKYVHVSEVGNTTGSGVGGQLAQRGLFRDRLLDKPVQKDILQESFINTMPAWVNMLLLSSSGPIKTPVNACATSAVSIELACESLLTGKAKIMIAGATEDITEESSYEFANMKATSNAVDELEHGRTPAEMSRPTTTTRNGFMEAHGSGNHILMSAATAIEIGCPIYGIVALSNTATDKEGRSVPAPGAGILTTARENSGKRASPLLDFNYRARQIKARRAQIKAWVESEYALLREELEELKASGELAPEDEESWIEERTTFIHREAKRQEKEALSTYNHQFYKNDPSIAPLRGALAVYGLTIDDIGVASFHGTSTKANDKNESRVLNTQLKHLGRTKGNALLAITQKYLTGHPKGPAASWMANGMIQCLLSGLIPGNRNADNVDVVMKDFEYILYPSRSIQTDGLKAGLLKSFGFGQAGGEILIIHPDYVLASLEESQYNEYKAKNAQRYAKAYRYLHDSITGVADFVQVKTEAPYSAELESSVYLNPSARTEYSKEKKSWHFTNKSASRATPSIGDATVTKNILSSLTEQQAGKKGVGVDVELTNAFNVENATFIERNFTPAEIEYCNSRPDPQASFTGRWSAKEAVFKAISSYGNIASSGAGAPLNEIEIKSNEVGAPEVVLTGKAKEAAGAAGVKSVSVSISHSGAYSVAVALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9B6</accession>
    <name>A0A367K9B6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000174">
        <property type="protein sequence ID" value="RCH98750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9B6"/>
    <dbReference type="STRING" id="86630.A0A367K9B6"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="174" mass="20074" checksum="31416F1C640FA2B8" modified="2018-11-07" version="1">MGTPDESYDKGVEYRLAGNEALILDSDLFYTLALQNYYNALLHLKALGGTKEKEKYKEASDTQLVMIYNNMTAVFAKQERWDRVLFYAKKASELDPKNTKTKFRMGQAYLRLENVDEAKTLLEQVLAENPGDALVKQELSKVAVANKQREEKEKMIYRAMMTKLAQENERDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA11</accession>
    <name>A0A367KA11_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000150">
        <property type="protein sequence ID" value="RCH99054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA11"/>
    <dbReference type="STRING" id="86630.A0A367KA11"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="138"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="59899" checksum="B47F6E76B551B75E" modified="2018-11-07" version="1">MKINIEKNSPIQPPLLTPSSSITTTYSLFDSHPFNDYPELFRKHSIQGDGADFLDPNTPSTRRASSPTILSQCAKCLLQYQSILSVASCGQHRICHNCQRSKDCPTCTKTMTTPYNVTAKEYVPTFAYVPAVYPCAKVTNIPWDVSQNDVRNFFGNCRLPSSSVYTQSIHILMDRTTGKTLSDAYVEFASVSDLWRAIETRSEKPLKGRIVTVTECSPEELLSVVFPKWRGQFQGNMAIPPTSEVVKTMSTAAGGGAHSACPPFITREEINSLLVVCKNYKLHFSRKCAERPFENIITVITKYPWHQAHLITTIHRDHIYELLKLSIESLKTHLSKDYIQIDPTLLERLVRAGIMCPAFTERQKMTLLQTSRLEKCPVDIVSFMYPMYPFAQSADYYSLPKQQQQQQQQKQQQQQQQRPVMTKRHSDDIFSFHQINVENVLGDDPASISSLIRDIQQQCQIEDRPSKPTENKMASHGIPLLLHPLESKGSPWTSSSSSTSSLPLSNSKSDIWKASSPVLESNKLTSSKALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAR9</accession>
    <name>A0A367KAR9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000139">
        <property type="protein sequence ID" value="RCH99209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAR9"/>
    <dbReference type="OrthoDB" id="2269041at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="189" mass="21679" checksum="5366F140D16A3E1C" modified="2018-11-07" version="1">MTNHPRKVQKVYYSPTILEKPKTSQHMDIDAEDEEAGTILVALAKQANRMNSNIKLSSIMLTEKPTRSHSMSIKNLIDTESTDVTPCSSYSTGHDFYQSSQRQTLVPYQSNAFKQPDIMKEAYKLSTSSSSPTQELKIRRSSIHVHISYKIHAHKIRAQHTHSTYYPNIHHHTASYHPTIPYHYKDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB16</accession>
    <name>A0A367KB16_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000125">
        <property type="protein sequence ID" value="RCH99422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB16"/>
    <dbReference type="STRING" id="86630.A0A367KB16"/>
    <dbReference type="OrthoDB" id="2358153at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="363" mass="41255" checksum="FCE990B6A33B2E7D" modified="2018-11-07" version="1">MTGNNLFQLAQIVTELPLHQQGPISTKNDHSRPLVMRKNACIICAVCFTCSGYYGINCQCIEMQPRRGKNLPQNGLDSRAKKLNKLDRNDYEFTIKWLNENIHQIYRDKENKVIGLNEMTEVSLCKAHSSTLYRAKKKHQRSNQAPPSPADSSGTSEDHPRLFGLAAKVRDLPYLAQPSPPECPTASTSMKRKRGIEPSSSTSTPVLNNMTYISDPRQPPSCSFSSQLLPPLRNTALNSLTYNLQHQLSFIHHQHHQHHQQQQQQQQQQQIETVSLKSITNDSIYYIRNLAITDTYTFRDLLSEIDLSTPPPPGKRIVITDIEKKKFFPLSQPIRSVIPNPDKTHVEFYLGLSDKASIDWSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCA8</accession>
    <name>A0A367KCA8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000122">
        <property type="protein sequence ID" value="RCH99461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCA8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="51" mass="5161" checksum="BAC2730A93933143" modified="2018-11-07" version="1" fragment="single">DPFYPSNIPINMGERTTVTGGRINGGSGGGGIAAAPGACRRQSCLNGREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCM2</accession>
    <name>A0A367KCM2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RBM42</name>
        <name evidence="5" type="ORF">CU097_014813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000089">
        <property type="protein sequence ID" value="RCH99955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCM2"/>
    <dbReference type="STRING" id="86630.A0A367KCM2"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="32536" checksum="675CF4B21493EB5F" modified="2018-11-07" version="1">MPSDKKNKETAQSTADSYAAYSEAGYQAAGSEYDYSNQYYYGYDYSTGTYADTSATAADYNNYNQYYSQYYDSSTYSTKSTSGASSSYKPTGTLAAAGPSPYTPVTTTSNNATSGVKTYYPNQSNPNNPVGPVIITKSGYAGPSNTTATSSSGNSSSDKDKKKKKKAYIRVAGGEVWEDPTLVDWDDQDYRLFAGDLGNEVTEELLYKTFSKYPSLIRTRVVRDSRTMKSKGYGFISFKDPDDFVRAWREMNGKYVGNRPIKLRKSTWKERNIEIKAKKERERMGPYSKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD98</accession>
    <name>A0A367KD98_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_008842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000076">
        <property type="protein sequence ID" value="RCI00168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD98"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="159" mass="18628" checksum="838ACD771E775C41" modified="2018-11-07" version="1">MYNTPKRFPPVCRFYSQGTCRAGQNCNFAHVLPFGDKANGNSSDKDPYSIQKAIRDLEVEQVEKKYKANIKKTTNYQNHTSIELVLPLESDKQIEVHLVIPYNYPDLQCTLQIHNLDLMPEIQSKIQTAFEDDEWHQMKHKTLIQQLDWLTTHFNKFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KES8</accession>
    <name>A0A367KES8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000043">
        <property type="protein sequence ID" value="RCI00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KES8"/>
    <dbReference type="STRING" id="86630.A0A367KES8"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="286" mass="31600" checksum="94E2A800007995A1" modified="2018-11-07" version="1">MSTNPHTEKAHQALSSLKELASTTDGWTFVQEKEGVKLYNKTVEGSPIPLVRGDIVVEGDQYTPQQLLAVCTFPGCRKIWDEKYDTSEIKQLYNRFESLFWTKLKTPWPISPRDIAGTSLREFSENGGYIVLTSVTDSQIPENSGVVRANLILSGWKVEKTSTGISIVYITQIDLAGSIPTSFLKTVQQQVPLCAGKVVKYIKDFGYPPLCLDATATFKKESFDHGKREYTAELDGEGEAKWSYSKQMYPGGVRVHVSGNGSVEVVNHEIILKGVNGPATVTITKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG67</accession>
    <name>A0A367KG67_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide exchange factor lte1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LTE1</name>
        <name evidence="5" type="ORF">CU097_015533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000020">
        <property type="protein sequence ID" value="RCI01215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG67"/>
    <dbReference type="STRING" id="86630.A0A367KG67"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="72"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="269"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="552" mass="65440" checksum="F481BE15B8CE2055" modified="2018-11-07" version="1">MHKNHLEPVPSLPPIPNSKFIKKFGRSHKEQDKLPVNQSNTSYAPKEPIENDPHLFDLLLNDSLHFIHYGKTDSTVTSATVEKLVEKLTREMNYDFLMDFFLTFRQYLTPIKLCKLLISRFRWTLLEETDERQLIRIRTFVVIRHWLTHYWTHDFMNSHTLRFMLCTFLTQLRTHPAILTSPRNERIVSNLRKIMKRQRRFYRHLDTNDQQREPSWTGKLGHTIRRSASFSVYNHSLLCKPFHMDLCHSKLLSLITHQDNYKSVVLKYRSEIIAQQFCLIEKDMLQTVSWDELIELRWRKKGSSTRHSVVQDTNLKGVELLIDFFNKTCQWVTCEIVRSTPLETRVQVIEKFIRIAFKCYQHRNYSTLMQILLGLQSPAVTRLERTWERVNQVQKDLLNQLKELAKPFKNWKNIRDCMTKATEEVTESFAVECVLTQSLKGFEHVNGCIPFLGLYLSDLVFLAELPTFIKANADTNNEDYIEHDKKLYERLCHPLVNYNKFRITASVIKHVLTFQVLSRAYKFKIHQHLFTQLQTVSILDNSQIREASFLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGL4</accession>
    <name>A0A367KGL4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">APN2_2</name>
        <name evidence="16" type="ORF">CU097_013034</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="PJQL01000013">
        <property type="protein sequence ID" value="RCI01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGL4"/>
    <dbReference type="STRING" id="86630.A0A367KGL4"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="329"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="485" mass="54968" checksum="599F0DCAF5D0D652" modified="2018-11-07" version="1">MRILTWNVNGLATTLQYHPWHEKKSYKFLLDTLGADIICLQEVKCQRSKLTRDMAIVSGYNAYHSFSKAKLGYSGTAVYVKDHLPLPVKVSEGITGVLDKTANEEMTQFVNTLATPAETLDAEGRCIILDFDVFILFNIYFPNYASEARGVFIMDYYACVRKRIDMYLEKGKQVILVGDVNAVHEELDHCDPKESMRVNNLEDFKDLPHRRWVDELIDPKGPLIDMARHFHPNRRGMFTCWNTRINARPANYGTRIDYILASKGLKDRFIYADIQPDVMGSDHCPVYADFDIAPDTLPQGNESSALLTTNFSEFSNKQKKLHSYFTAKSNTTSSSSSSLSSNVATTTTATTTTTTTTSSSLSSASGEQSKRRNNSNTETRTTTKKQKGLDSFFIKENKDQDYCYIDKQDFNNNDKAAWSTLFRPPQIPKCRGHNETCVERTVTKKGPNLGRVFYLCPKPVGPQDGPKELYSCNFFAWKQQSSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJ61</accession>
    <name>A0A367IJ61_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005728">
        <property type="protein sequence ID" value="RCH77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJ61"/>
    <dbReference type="STRING" id="86630.A0A367IJ61"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="12779" checksum="848B76BD5A7057E4" modified="2018-11-07" version="1" fragment="single">ASEMVLDIRGGSIASGATICQYTKKTEDAENQKWGLTVEGSIHPESNKGLVLTVKEDEMVRSSLYLAERKTCDNKGQCWNFVLPVFKKKQVTTTVKQSFKTAAYPSGWFFIRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJ87</accession>
    <name>A0A367IJ87_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005709">
        <property type="protein sequence ID" value="RCH77729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJ87"/>
    <dbReference type="STRING" id="86630.A0A367IJ87"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH77729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="120" mass="13781" checksum="160B91DC2A92D954" modified="2018-11-07" version="1" fragment="single">KNPYFDPSLGAPVAPKNRRSRQLKFVQPGKYIDIANQERAKAQLEKLKQEITESVKKAGMQTEFDVSDKAIKRDAPPAVEWWDAPFTKTYEELNDADIDPDKYETLVTMYIHHPVPIKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKX4</accession>
    <name>A0A367IKX4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005249">
        <property type="protein sequence ID" value="RCH78334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKX4"/>
    <dbReference type="STRING" id="86630.A0A367IKX4"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="52" mass="6006" checksum="FC054846A07E19F1" modified="2018-11-07" version="1" fragment="single">MNEKVEPVNRQDERELVHRLDKRLLLFAMFGNLVKSLDNSNLASAFISGMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILT1</accession>
    <name>A0A367ILT1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005011">
        <property type="protein sequence ID" value="RCH78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILT1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="54" mass="6535" checksum="97874821CCFBAC2D" modified="2018-11-07" version="1" fragment="single">TKERFQREASSPRMVRVAKVAKAARVVRTERMATRKTSMKRERRERTTTRRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPI3</accession>
    <name>A0A367IPI3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004427">
        <property type="protein sequence ID" value="RCH79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPI3"/>
    <dbReference type="STRING" id="86630.A0A367IPI3"/>
    <dbReference type="OrthoDB" id="10598960at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="8263" checksum="80B7CBC568F7ECF8" modified="2018-11-07" version="1" fragment="single">MFELVGVHGRITLDNVYLNGLHALRRLHLRNLSNRPISIKMRSNLRNQIAFQLENENISNLSDFSATTNTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRU3</accession>
    <name>A0A367IRU3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone acetyltransferase type B subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HAT2_1</name>
        <name evidence="6" type="ORF">CU097_002473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003960">
        <property type="protein sequence ID" value="RCH80356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRU3"/>
    <dbReference type="STRING" id="86630.A0A367IRU3"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH80356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="325" mass="36911" checksum="DB492E1F9D38F66B" modified="2018-11-07" version="1" fragment="single">DNGWWSQEMLIGTHTNDLEPNFAQHLRLDIPEKKSDKTKFSISQRVFHEGEVNRARYMPLDPSVFATKTATGDVLVFDRKVNHSQEVCDPLLKLKGHRMEGYGLAWCHHESKKNHLLSAGFDQLICHWDIGMAPNQDKELEPLQVYRGHTSCVEDVSWNATNDCIFASVADDKKLMIWDTRSPGQPVQSVQAHTADINSVAFHPKRDWMLATGSSDKTIGLFDIRKIDDKLYSFESHEGEVSQVAWSPHEDPILASAASDRKIIVWDLREIGKEQTPDDAEDGPPEVLFVHSGHTAKINDFSWNPEEPWVISSCAEDNVVQIWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT94</accession>
    <name>A0A367IT94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003672">
        <property type="protein sequence ID" value="RCH80914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT94"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="63" mass="7349" checksum="032279532ECB572C" modified="2018-11-07" version="1">MQAVAAWFAVEKGADERIIEKDEIEIIDDEQVEPDVEEVENEEENEEEKEEEISEEKLILEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV48</accession>
    <name>A0A367IV48_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_000375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003382">
        <property type="protein sequence ID" value="RCH81558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV48"/>
    <dbReference type="STRING" id="86630.A0A367IV48"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="176" mass="19868" checksum="33EE14A840C38FBC" modified="2018-11-07" version="1" fragment="single">MTIDSHMRAPVFFISHGGPNLLDNKEKPGDFYTWFGQYIQQELKPKAIVIISAHWQGEGKNGIFVDTSEKPKLIYDFYNFPKHYYEETWDHQGSPQLANRVIDLLKKAGLSPSGEKYGNDHGVWVPLKRAMKSNPDIPIVEVSTFAHEDMPMHIKMGEALEPLRDEGVVIIGSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX45</accession>
    <name>A0A367IX45_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 49 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_004476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003169">
        <property type="protein sequence ID" value="RCH82051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX45"/>
    <dbReference type="STRING" id="86630.A0A367IX45"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH82051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="55566" checksum="AFC929CC947A8B1F" modified="2018-11-07" version="1">MRLEPTLKVSRLAKYAIFAYVVLSFIYASHHYFSIHSQHRSSLSSSSSASITINTTSDKKTWARKQEILHKLENIERQRERRPMMWSIKGGKSQHTLSHNFMSSKIFSSSMGLDHITPYYFKASKINNQEDITLATLVTRNRFAVLSRLATNYKGPISAAIHINDDQEKTKTIQELNKIYRSNPDMQAYVDIHLIIDKYDRQFNMWRNIAKLFTRTEYLMMLDVDFHLCTDFRKSIWQNAELATMLRSGKVAFVVPAFEYLDQKDGLDWRTFPTKKSQLVDQVNNMKLDSFHSTWVSGHGATNYSHWYTTDQTYPVTQYEYSYEPYIIYKKEGTPWCDERFIGYGANKAACLYEIYISGVDFWVLPNDFLIHQSHKYANHDRTRERVHNKELYANFRKEVCLRYSRKYVIENTWYTPAADNMKKVCTDIPKWKYLSGIPKAQREADKLAEEAAKQEQLLKNQSHYDEEEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXE5</accession>
    <name>A0A367IXE5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003070">
        <property type="protein sequence ID" value="RCH82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXE5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="16432" checksum="01C13653236BDE08" modified="2018-11-07" version="1">MQHEHSEQFETFTNQYISQSFAASLTLGLEQDFAGTIAGLSTALSMQQCQLIVRDKTLYVQSTDQQQLAYLGPIGETPQPTEPQAQELLELIEWSTPETVLEEQPTPVLTVRRRRRRHVLSKRGKERERHKIGITLLKFRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXK6</accession>
    <name>A0A367IXK6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003028">
        <property type="protein sequence ID" value="RCH82397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXK6"/>
    <dbReference type="STRING" id="86630.A0A367IXK6"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="64" mass="7513" checksum="2E48E3BD8E4A6AED" modified="2018-11-07" version="1">MKELEKQIHKCQERANHWEILHNNSQALIEDMKKGCLAHRDENEQLIKLANRLQLELQKGGAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J094</accession>
    <name>A0A367J094_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002698">
        <property type="protein sequence ID" value="RCH83330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J094"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="67" mass="7886" checksum="1CBC9C00412E3ADA" modified="2018-11-07" version="1" fragment="single">FKLDPSNIVHNEVLKPRIYLISLGINNYCQLWKSIKVTNNNIYQYAASEALNYQENRSRPLDYNNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1H7</accession>
    <name>A0A367J1H7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PEX12_2</name>
        <name evidence="19" type="ORF">CU097_006751</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002553">
        <property type="protein sequence ID" value="RCH83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1H7"/>
    <dbReference type="STRING" id="86630.A0A367J1H7"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="377" mass="43324" checksum="68293F72C1E7B3E9" modified="2018-11-07" version="1">MEFMSALGSQEDAYRPSLFELVAQDKLKELLQPAIQYVLAIYAQRYPRLLLRIVNNHEEFYALLMLLIERHYLKEWSGSFAENFYGLKRVSSLSTNNFVSPINSKASKLSAKDINRSLLVLVGLPYIKCKLDLLYQRASGSSDIILDEQVEIENEELADSNTKASRKLLIRLKRLFKKIYPIVNFLYHISNLGYNIGYLFGKTKYYTPWLHLLGIEVKRMSMDDYRAYYEKTANGTSDGISLKNPLRAMSMISGKVIEFLKVLLPMSIFFFKFLEWWYSSEFSRGNALRKGEEGENAIPPPEKIKPHPQGTSVPSRPNTCPLCLTNPINNPTAMPSGYVFCYTCAYHYLQEHGRCPVTWIKVSKDPQSLVKLYADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1P8</accession>
    <name>A0A367J1P8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_003386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002563">
        <property type="protein sequence ID" value="RCH83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1P8"/>
    <dbReference type="STRING" id="86630.A0A367J1P8"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="440" mass="50180" checksum="A432A1D0D734F893" modified="2018-11-07" version="1">MVSKLASLLGDAPPSLEELKHISKSPSTTNVTAQSTKSAPIQNPDQNQTKAPSRQDQPITSAQQVQKDVKADDNDLISSILEQVTTGVKSTFIPPQIPSAPAPSQQQSLMPSKRPSQEVNALTAPTNIQKKKRSRKNKKNKNKVIPEVVHRDTPKEEEDVDFDTEMDRYFQATTNAKKKQEEKREPISLHEQKDTSAQKCSPKKRSMEEVAYEILGKPIKKLKQQQQQKQKQTQPKKAPQPKKEFVPLVPCKYYAQGYCKDGDKCTFKHDNTNDPEVCPLWVKGKCKNDELCRFKHEGPRDIKICQFYKTQSCTKGDACPFSHDLKLEPCRFYHIQKVCEQGDKCPYSHEALTDESLQRLRQLTGPCRFWQFKGYCVTGDQCLFAHDDISEEERKKLESTITPCIYYHIKGECRSGDDCFYLHDEATPEQVAKLKSTQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J333</accession>
    <name>A0A367J333_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002386">
        <property type="protein sequence ID" value="RCH84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J333"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10078" checksum="E35B5B76642A0910" modified="2018-11-07" version="1">MDIPGMSLQKRDSPWMLVWPRVGSISPFESMAKQLKGNGICIDDKSQYKFGGLIKPFCPKKLELLLLETSGHLSNSDKIKVNFDPPYGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J429</accession>
    <name>A0A367J429_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002301">
        <property type="protein sequence ID" value="RCH84666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J429"/>
    <dbReference type="OrthoDB" id="2449831at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016827754" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="156" mass="17342" checksum="1AE75C5B1CB0D850" modified="2018-11-07" version="1">MKFIHWFILAITAAVTTQAVVTAKKEGGEICIQIIVPCPERCKKNCIYPDLPCPFTHPPKCPGDRSFPKDPQCLVACPKDNKPPCPDECTDCYYESANDPCCPKLLKAICPPVQCFAPCPKENKPPCPDECANNCTYKRSHDPCCPHLLKPICYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4F4</accession>
    <name>A0A367J4F4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002263">
        <property type="protein sequence ID" value="RCH84803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4F4"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16731" checksum="1AAA848C746661BA" modified="2018-11-07" version="1">MLHHVKQPLFTIRHYSTQLTGYRKYAQQFKSKPGSYMTAFAVLHELTAIAPFPVIYYALDASSITIPFSNSLVEEGNKFINKVRVHYGYEQLEPDNKVMIHLVTTYCIVKALLPVRLAASAAMTPMVAEKLISPSVQFIRRRVLSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5A0</accession>
    <name>A0A367J5A0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_003538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002189">
        <property type="protein sequence ID" value="RCH85076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5A0"/>
    <dbReference type="STRING" id="86630.A0A367J5A0"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="155" mass="17705" checksum="1390AFDBF9915FA8" modified="2018-11-07" version="1">MSWRKIDIDQYDEDAYTQDEILAEFETGLSPEEVNNATQTRNTDVRNFISRGDLNNALTRALEDPPYGRHLEAAKTESTKMIAEVLNMFRAGDISDIVKSLNHEQQDVLMKYIYAGLSKPELYNSSVLLTWHEKLTEIAGNGCIVRVMTDKRTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J619</accession>
    <name>A0A367J619_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA repair protein rad4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002136">
        <property type="protein sequence ID" value="RCH85289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J619"/>
    <dbReference type="STRING" id="86630.A0A367J619"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="507"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="560"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="629"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH85289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="89727" checksum="4A8CFFD3F2C89051" modified="2018-11-07" version="1">MAATRNLGKRKRGKQSESSSQRTTYMSRNARDQPEDQPESSLNASRKRRTDLSNSETAVKKRSKGKQKEESVIIDLQDDALMTCENEEGGFITMVEDEEKDKQEEDEEDDGDEEDEEDEDEIDWETVHLPPTLPEQMHEELVTDVVYKDVEVVFEAPRAVLKKSKWEMEYQRNLREWIHHGHVVALTAHYILRNRWCSSSKIKSRCSKIVPDHARNLLSKETSESGVITGIKWLLNWWSNYFSVTGPGLVTRPYSDFADINYDVLQEMILKHESNENADWIDSLDDFVNLLSKKEGTSDTCAELFVAVLRFCGCDARLVCSLQPVPHKIPSESTSKKKSGKGQDGAEKDKSNAEETDEKSNILFQFRTPTKSYVNPNVQLRQKNAKPPCVWAEVYCLESKKWICVDPVRGIINKPALMEPATLNRSNQLSYVLAMDDKKRHNITDVTRRYTSNLEKAIRLRDRPLTKREQSSGLKPWSEVFLAMLCHKPKMGEKERLEIQDLEKQEKKERMPTSIGGFKNHPLYALERHLKKFEVLHPKEPVLGSIRGEKIYPRQCIKTVATADSYRKQGREIIEGEQPIKMVKSSATTLEKKRLHEMAKQDGQEVLVPCYGEWQTRKIVPDPVVNGKVPKNAYGNIDLFTPEMLPPGAVHIPINGLGKVAKMLGIDYADAVTGFEFTKMRSVPIIDGIVVAEEYQYVLMEALEEQEKNNALKAIEKQEKEVYLRWRKLIKRLIIKARVDSEYGASKNASRRDHNDDVWAVYSATSNDNSDTYPGGGFLPEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6H1</accession>
    <name>A0A367J6H1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_009344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002077">
        <property type="protein sequence ID" value="RCH85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6H1"/>
    <dbReference type="STRING" id="86630.A0A367J6H1"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="270" mass="30410" checksum="23FE6D4D414E1157" modified="2018-11-07" version="1" fragment="single">KNKENGWDVGIHVDAASGGFVAPFVVPELEWDFRCSRVVSINVSGHKYGMTYAGVGWCIWRSPEYLPKSLIFNINYLGSEQASFTLNFSKGAAHVIAQYYVLIRLGRNGFKKIMSNLTATADHLAARLKATGYFEIMSETGGRGLPLVAFRLKEKHHFNEFDISSKLRERGWIVPAYTMAPKVEHLKMLRVVVREDFSRSRCEILVRDIIAAVRALEAVDEENINKRREHIEKHSLTSLHASHEATYKPKTDDGADVETTEEPKAAKGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6T2</accession>
    <name>A0A367J6T2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 snoRNP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UTP6_2</name>
        <name evidence="8" type="ORF">CU097_008617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002042">
        <property type="protein sequence ID" value="RCH85664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6T2"/>
    <dbReference type="STRING" id="86630.A0A367J6T2"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="7">
        <location>
            <begin position="363"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="478" mass="56658" checksum="6010538871C48208" modified="2018-11-07" version="1">MADQVQYRLERMLPELEALERKKIFTHEEIKSIIKKRTNHEYAMSRRIKQKIDFLRSIEYEINLEELRKKRIKRLGYNFDPKEKNLQYSGIKRIYSLFKRATTRFTGDLKLWLQYIDFAKKNDSNNILSGIFVQAIQYHPMNPSLWIMAASWEHEHNSNIAAARTLMQRAIRLMPENQLLWHEYFRLELIYIEKIKLRRRILGIAEQSDEQKDIEAMEVDAKEEDSIQLPALTGEDVDSWKEDRGESTKFKLSAEEAKSLEEANNPILKGLLSRIIYDNAIQAIPHHLEFREKFIDIYREFSNTEEHIEYIYETIRRDMSQVPTARAYLAKRHLFVPKPEQEKDEQTQYISVSDPAFIPALRQCVEEFEGALNDLTGSDMWELYIDFILGWYSIVSEENLKLYLKKLAQRTFKACEKKDLLSKTLYEKWTQFAMDQQDVEKASNLIKAGLKAYPHSVPLWLNKVQLSKDDKDAQLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7F9</accession>
    <name>A0A367J7F9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FET5_2</name>
        <name evidence="8" type="ORF">CU097_002567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001994">
        <property type="protein sequence ID" value="RCH85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7F9"/>
    <dbReference type="STRING" id="86630.A0A367J7F9"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="336" mass="38826" checksum="CCEA9522C88B0378" modified="2018-11-07" version="1">MNKDKQVGLLQNQKVYFINIFRGRHCQLVMGPAGSGKSTYCATMMTHCQTAGRRVHLVNLDPAAESFEYEPTIDIRDLITLEDVMEELNYGPNGGLIYCLEFLVNNIDWLEEEIGDYEDDYLIFDCPGQIELYTHFPIMKRLCEALGRLNMSICGVYCLESQFIEDKSKYFSGVLSAMSAMVNLEIPHINVMTKMDLIEGDYGNKRASEEEEQNEDDEESAATQKRRRQRRRRRLLEKAMTERELDRYLEPDPLLIAEEAEVVYEGEEQPTARSLKFQALTQAIVQLIDDYSMVKFIPLNITDEDSIEYVLSHVDNSMQYGEDLEPKEPEDVPEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7H5</accession>
    <name>A0A367J7H5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Farnesyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERG20_2</name>
        <name evidence="11" type="ORF">CU097_008973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001987">
        <property type="protein sequence ID" value="RCH85904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7H5"/>
    <dbReference type="SMR" id="A0A367J7H5"/>
    <dbReference type="STRING" id="86630.A0A367J7H5"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH85904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="352" mass="40709" checksum="E30A51BB53AF1281" modified="2018-11-07" version="1">MVAVKLQKEENRKAFLSVFPTLADEVLAELRKYNMPEDAYEWTKKNLFYNVPGGKLNRGISVVDTVRILKGESVTEDDIFKATVLGWLVEFLQAFFLVSDDIMDASITRRGQPCWYKTEGVGMVAINDAFILESCIYIFLKKYFRNTDYYIELVELFHEVTFQTELGQLCDLITAPEDHVDLSKFSVKKHQFIVIYKTAYYSFYLPVALGMYMVGIKDEKAFKSAHDILIPLGEYFQVQDDYLDCYGAPEVIGKIGTDIMDNKCSWLINQALAKANPEQRKILDENYGKKDSEAEAKVKQLYIDLDIEGTYKAYEEKSYRELTALIEQLDESVGLKKQVFIEFMDKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8C9</accession>
    <name>A0A367J8C9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001916">
        <property type="protein sequence ID" value="RCH86214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8C9"/>
    <dbReference type="STRING" id="86630.A0A367J8C9"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="320" mass="35240" checksum="C468BC6813173F0F" modified="2018-11-07" version="1">MPVPLEYNTSLRRMSTLTIPKQDINFDTYDFQRCTPQNDIKDAFESKDLEASYCRDFVCCGLVLNDLHDLLQHYEECHVHLEEEDNFDNESDCWSPIEEKTEYIDMLKKKAVTYLSDENEDDIKKSCGKKRSYSQMTCANSALEILTQSAAKKLALAGGNGVESLITDEEFLAQAGAILACANANLNADKPYKCPVSGCDKAYKNPNGLKYHNQHGHCNLINDDSESLASKPYQCTIGDCGKRYKNLNGLKYHIEHSHMAALNQTLASFGNSLFSLPSSSISSSSSSSSSSASSSTSSSPMLGAAPITFSLDNPSIFPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8I1</accession>
    <name>A0A367J8I1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001910">
        <property type="protein sequence ID" value="RCH86243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8I1"/>
    <dbReference type="STRING" id="86630.A0A367J8I1"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="493"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH86243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="599" mass="68830" checksum="607D4345BD431F30" modified="2018-11-07" version="1">MSAVAEEVETLKSKLKEYEKKEASWKEEHAQLLNFQKKLTQAGSHLKALTQENANLSKKVTEEKKQREELSKEINDLKTKLDDTKKGHQKEIKQLVDILETAIDEEHKNIPDVSTSTLLDSYIKSVQKRIPKKAANAPLSQAAQDDIETSLKNILQDPENGTIEDSSITPSLRLTLEQVRSDLRQLQNTVNSHQSNIDEVQKDLKRQITQLNITNNELSEEKEKLSSEKEELESQIESLERQLSDAKNNLTESENKRDSLHKEHQSLIGKLAHIKETLTPRLEQDKQLREKVSELTNQLDAANLQLEDCQAQLNIKEQEHIEEQEKQQRAIRNLSQQVEELRTKCEEYESMTMEMDVQCSQVQEKLQKTQTELEALKIKLATEQAERESEKTSLTNLQTVLEEFQATKDAEMQAAIEHVQKQLDVAKKSWKEYEQRALTAEAALEKYQQGVEKAERYEKEIKEKNLLIGKLRHEAIILNEHLVEAMRKLKEEASEDSVDRQLISNLLIGFLNTPRGDRKRYDILTIIANVLHLTEEEKEQIGLLRPKQSLGSPPPTAIEQPATESFTDAWISFLLKESSPLRRNRSAVTLSSTENHIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9G4</accession>
    <name>A0A367J9G4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NOP9</name>
        <name evidence="7" type="ORF">CU097_005819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001843">
        <property type="protein sequence ID" value="RCH86550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9G4"/>
    <dbReference type="STRING" id="86630.A0A367J9G4"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="550"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="652" mass="75089" checksum="09EF205CCD6186B2" modified="2018-11-07" version="1">MPRTERQGRHNKKRGKKGSKKNDQVEAMEDVQQLNEQQESHQVEQHFQAAHFGELDEEMLGYFKNVEETLDDPQFETGEDLRLFVENVYNEVDGNEFRLATNYSCSLILEKLLKVSDAKQLRVFMSKIRGNTVELFAHRFASHVCQTLLTLAADVVEQEMEQGGVAETDQPSMEELVLSICEDIKPHVGGLISQQFASHDIRILLFVLVGRRIDETSDTKGQLRSKKSLQYKKENNDTLTKASSHASSKRKVPESFKDMFRALTTALAINMSETEVRSLSVHKVANPVLQLLLEMQEDDKEGQKARNILIDRVLWGIVTDIDSKEENKDRDAWFETLIRDPVGSHLLEVILKCAPDAIYRKVYKTYIKTKLEKFSLHPIANFVVQHLISHVRKSKQLDEMIKELSGSFEKLISKGKYGVIRSLVESSVKYESSQQEIVEQLATALHMPKDSDRKEFVNCCMRMWTIKQWNESSEEDRRNLYKFHLQGSLIVQGIAKMESPANSILVNSFLSQRPDVVYQWCFSPSGSRAVEAILSSSHVEAKMKKKIIRDLLGKYTSLAKDKFGSHIIEKCWLAADIDMKEKIASELVKHEHDLSSHYIGKGILWTCRIDQFKRKRNDWIEREKGAERKREMFKDILGEDVSMPLLKKHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCD0</accession>
    <name>A0A367JCD0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001625">
        <property type="protein sequence ID" value="RCH87594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCD0"/>
    <dbReference type="STRING" id="86630.A0A367JCD0"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="529" mass="60358" checksum="A71DD4182F9805D8" modified="2018-11-07" version="1" fragment="single">MASAKLVQISKDIDAARCNGNWAAIPELARRYKKYNSEGIILEQTILAEASLSQLCQSARQQQQQTIDYQEKTLRMATLEARLDPEQVRSIQQQLRNVIQLPDQDDTFALQKEFAIIVLTRSHFECGEYEQAIELVNKLSFTKDQVSQGYGLVLFLQARIIKAISYELSGDMNHAIETYEGVESLVAEYPNTKYKLWIEWAEMALYRAVLLGLTNKESVDVSSLLGFIRQYQRIANTQANNWRIDKRMVLTRHAIQFVSNSYRTGQYVPPGGSSEDDHEIYRQSFIAELSQLHAIYEKMLYMQVPMPRAGQVNQPVLDFVDQLMADFELMGTTTQDLRGLREVLDRAAQRTFNSPSIARHLYNTLYRLGEYDEAEYALRSYLHLVDLISYDWTETHKNGDALAIDQDGISMTIPTARPDLPEDDAHDESDCIGDIKNVESEQVSDMLQVLITAIRMYCNDLAKSVDAVEMAEIAKELYQKNKTKIPISIAAYLHRAIGVAYGLLGCQTFDPEVRPIYHEKALSYLKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCM0</accession>
    <name>A0A367JCM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="PJQL01001608">
        <property type="protein sequence ID" value="RCH87684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCM0"/>
    <dbReference type="STRING" id="86630.A0A367JCM0"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="464"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH87684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="724" mass="82499" checksum="7702A6E8E99332AA" modified="2018-11-07" version="1">MKILYPGISRHPSKNQWFLVTNNSTYVIGIVENVLLNLHWGPRLVTMQDVELPAELEKERSSQDPAITSAREECPFFGGLRYGPDLLRAIFANGTKELDLIYHSSTLDQHTLKITLVDRVYDYLKIGLEYILDIENDMIIRGAILSGTDDPEKCFYFTKSQTAAWHLGPPAHGTHRELVTLAGAWSSEMQVQIHSMNPGTSHVLSSVRGIPSAQAYPYFAIKDQAKDGEHTDCEVYFGTLGWSGNWSIEISTDIESKTRIIGGWHDREPKIKANRELALPLFVAGFAPDGLSGARKRLTRHIRREREQHLNEENILSPVLYNGWEACGFGVNIKNQMDMASKAAKLGAELFVLDDGWFKGRHLDDAGLGDWYVDQTKFPEGLKPLSDHVHKLGMKFGLWFEPEMVNPDSDLYRQHPEWVYHYTDRPRHLERNQLVLNITRKDVREYILRRMCDIIKRANVDFIKWDMNRPISEANGDGVVSWIMHPRIVHAMMEKLKQEFKHLRIETCASGGGRADLSMLKKTDLCWPSDNTRPDARLKIQYGASFVMPPNMMSCWVTDMPNDDVYCIFPISYRFHVSFMGALGIGSDLTKLTEAELELYRGWIELYKTIRPIQQKGDLEFLVPPDSNRTHTVITQTTVGEGNASVVLAFRESSPFWLSLGPIRLRNLKKLCIYHVQIWEDNPFVPVFTGDMTGSSLMAKGLPLPYLTSKAYSSVVILLQIKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCY7</accession>
    <name>A0A367JCY7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001582">
        <property type="protein sequence ID" value="RCH87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCY7"/>
    <dbReference type="STRING" id="86630.A0A367JCY7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="331" mass="37516" checksum="E5BD8D51800E1846" modified="2018-11-07" version="1">MGNRFSALRKTKRIRSVNTTGQDDISSKTMNTYQEGALVTETTTAANPMALGLSREFHNEESSTYWLPKDDEEQMRLTGQHCAIKNLYGGNVLSSVKNTLDFEKGITILDVGCGSGAWVMDMIHEYPKCTYHGCDISDIRYKKVNVEKFIFTYGNVVKGLPYEDNSFDFVHMRLLILALREEEWPAAISELIRVTKPGGMIQLLEMDLRQQQKDDPSGALYRIGSAVRDICISKGQNPSIGTEFEKMLSKHSNIKIIQSDDRSCDMSTGTNTAKWFIWDSLQVLKSMQPVLTIKLGLKTDEEFDSFSEEFEHHIKTKESVCFYNSIAVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDA0</accession>
    <name>A0A367JDA0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001567">
        <property type="protein sequence ID" value="RCH87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDA0"/>
    <dbReference type="STRING" id="86630.A0A367JDA0"/>
    <dbReference type="OrthoDB" id="2287482at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="267" mass="30692" checksum="F66A42E7DC9E1953" modified="2018-11-07" version="1">MPAIMDVLSPPSTLLNTNDNTFNDSKERSYKELIKQLAAQVNTKPYGNIPPMSNNNKRKKKKKIQQERTIKRRMSHVEDWVVVDSKESIPDEEELNSSTDFSLTHVLPLHMPPPSLSEIQQDTHLLRSLITTQSYAISSSPPQLSNIDQQVWNETIAKLKKSLVVSSPTPKISSRHIIPLPPPPRKLVKRRRSEATTQPRFNPDTNAYTRDTRSNPDHLRMISAELNMIRSRKLLSPLKPRGFLPRRKDIFIRGEHRKVSPLTYEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDC4</accession>
    <name>A0A367JDC4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001555">
        <property type="protein sequence ID" value="RCH87972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDC4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="111" mass="12459" checksum="AC741A39CCC9CB3C" modified="2018-11-07" version="1">MAILCMRGVIGSTLCFSKPNMMNDNQAEISSSIYAVFKDFVVLEFFLHTEIKPETRNKFSNSMLLYLNGWTLHGQALNKHGHILIPRVRGVSRFGHIGLNDHAKALVDAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDH2</accession>
    <name>A0A367JDH2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_003546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001555">
        <property type="protein sequence ID" value="RCH87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDH2"/>
    <dbReference type="STRING" id="86630.A0A367JDH2"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="189"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="301"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="513" mass="57275" checksum="F39BEB1490BC2152" modified="2018-11-07" version="1">MKSVPGSPHPYYDEKASEREARIKSLFESLDCKKRGYLDADDVLGGFLKLTHLPAHTRYVTDLLAKCDTAHDGVIYYQEFRNYVLEKEKELWELFSEINQSSDFKLRPKDLENALKAAGIHVTNDDITNFIQCIDTEGNGYIDFQDWRDFLLLLPRETTLTEVYQYYQTSTQITHDAEVVIPHTDEAAINAYKYLAAGGIAGAVSRTCTAPFDRLKVYLITQTAYNPVHTTTAATGIMKQSAILNGLKNIYHQGGGFRAFFVGNGLNVIKIVPESAIKFYVFETAKSVLAELTNSEDKNDIPVGARFVAGGVAGLCAQFCIYPLETLKTRIMSSNAIHEKRHHHHCSAAYRSKQQSMIINTARSLYKAHGLRGFWPGLAVSLMGVFPYQALDMGIYETLKVTYLQYMNSQKDDQGKSKPPNVLVLWACGMVSGSIGATSVYPLNMIRTRLQAQGTPAHPYRYTSAWDAAKKTFQADGVRGFYKGLGPTLFKVVPSVSISYAVYEFSKRTLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEK3</accession>
    <name>A0A367JEK3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001492">
        <property type="protein sequence ID" value="RCH88299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEK3"/>
    <dbReference type="OrthoDB" id="2283959at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="318" mass="36280" checksum="C83D7D294FA25BEE" modified="2018-11-07" version="1">MYKTKTLAQQRALPKPVTKSVALFNDDSDDEENISMTDTLLLAQFLSTTGPEEYFKEHNKKQLNRASRLLKKLRKRPSTEKYDDFKLPMHSLIQEHNVSSGTLREASSFDQETILRRGNSNKHNPGDSINSNSTLRDSGVYSETSEKEPCMTLHEFHFPIVPHRPAPPPPTPTPSPGTTQNNLPTDIRTVPEAARHRRQVRIRHAQVQTQPSPEQAEDQTACPHCRQQVVKAPRTRRTSCPPALASGPTLEPSAKLLMAMIEQLKNQLAQEKECRQKLEQAMYQKERKEQLELEKTKWANECRALDKRLAMHNIPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEN4</accession>
    <name>A0A367JEN4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001476">
        <property type="protein sequence ID" value="RCH88384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEN4"/>
    <dbReference type="STRING" id="86630.A0A367JEN4"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="373"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="714" mass="82270" checksum="A89D36543FCF92CE" modified="2018-11-07" version="1">MLTKTNDVLSTPPPEQVEDIRKQYENMTYDEMSQRIAESYKQLSELLGNRISLPSTISTSTTLDDTTVDDCYDESIIERTDIDDATKKQKCTKLFLKSASSGDLEKMQKYLETMKPFIDINAKDEDGTTPLIYAACFGKYEIAQALLQAGAKADSQDSHGWTALMWATTNNHEALVKLLVEHGASSQTRSAKGRTAFDFVKSENSNKIADILANNPRDSISSTASSVLGLTAVESVTSAVSKDHYYPYEENYESLLNFDNENRPKLIEEYLTTNEQKHKEDQEEEQEQEEEEEEEEEDLEVKDTEFDWDNCMPDQMFVFAADDLPYILDTVISNLTLPVRNVQEIFLPANVVFLSARFAHYYSSLELAEQLLEGALDRISKIIKSNTDNVHILSYWMTNITRLLFYLKKDTGLVVTTANYQLKLSELISETYNYMVHDTEKRLHEVLELAMLEYDPIKTEEVNFTDDYWQRLFKRRSTTVEMQRNNSSYSNATETNSKVIISPQSITNLLSCTLYVLQSYEIHSAIIIQALAQFFHFISCELFNQMLTQKKYLCRSKAIQVRMNLSVLEEWIRNNNLPSNLLSYLKPSIQLVQLLQCITQLDTLQAMSTFDALNPLQIRRCIMNYRYETNEQKISDEIQLAVGHRKTLEKIRPTTMIEQHQEDEEEEQETKDSKFMLPFFVPTATQLSALYEKISPAIPQDWMEKLDKTSSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF43</accession>
    <name>A0A367JF43_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001458">
        <property type="protein sequence ID" value="RCH88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF43"/>
    <dbReference type="STRING" id="86630.A0A367JF43"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="33253" checksum="6F9A5526FA1DDECB" modified="2018-11-07" version="1">MITQNVNIAAVDPTFFDTKQEFHNDETSGYWLPKGEEEQKRLTAQHFAIKSLYGRNVMPSVTETLDLEGGITILDVGCSSGAWIMVSVQEYPNCIYHGCDIVDVTYKNVDVKQFTFSLGNVTNRLPYEDNTFDFVHMRLFVACLRKNEWPAALSEVIRVTKPGGMIQLGEFDLQPQNDSSSLYYRILSCFKDACKSRGQNPDIGSELETMLSKYSNVKVVESDHRTCDMSSGTPTAKMFIWDNLEAIKSMRRVLGPMLGIHNQKDLISFLKEYKHDLETKESVVGFAAVTVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFG9</accession>
    <name>A0A367JFG9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001459">
        <property type="protein sequence ID" value="RCH88481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFG9"/>
    <dbReference type="OrthoDB" id="2289151at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="8178" checksum="3A843F0E546A7DDF" modified="2018-11-07" version="1" fragment="single">DNPINGHSDALSAACVVLATAYLNHIVENFQRRVLYYLTVRLAIIYPDKPKGLLYKLADDFCWEILINGEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFS4</accession>
    <name>A0A367JFS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001419">
        <property type="protein sequence ID" value="RCH88719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFS4"/>
    <dbReference type="STRING" id="86630.A0A367JFS4"/>
    <dbReference type="OrthoDB" id="2287318at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016885692" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33568" checksum="A578622D0590A487" modified="2018-11-07" version="1">MKTHISLIIILFIPLLQFTLCDVILPTPTPTNNSPNAPPIVTTNEQNNNTPTHAPDADKAHHDDHDHDKKGPEITVETIYKTVTEQTTPSILSVSNSGSGAPLQQQPRNDTANNNNPNPSERNDRLTNNMTQNQQALKRMILILSLVGGLGVIAIVATIVIFTKIRAKNRRHREEATEAVAAATDSASTTSSSSDDSYSHRHSHHYENEQEDIVPSAPPALAMIEPPQRRYVISMISQTTASPSAPTAKELDAIVDDNDEVGSCSRYAAPQPEGPPPAYTPSAPPHYALPMDAVVLENVIPPRRHSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHG3</accession>
    <name>A0A367JHG3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RER2</name>
        <name evidence="5" type="ORF">CU097_010935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001299">
        <property type="protein sequence ID" value="RCH89380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHG3"/>
    <dbReference type="STRING" id="86630.A0A367JHG3"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="30719" checksum="E6C57ADC04DC3F5D" modified="2018-11-07" version="1">MNSLINYCEQFMLAILRKGKIPRHIGFILDGNRRYARKIGATSTKFGHYEGLKQLEKVLDLCMQLGVEVVTAFAFSIDNFNRSKEEVDYLMQLFCEAFDGFCERSSLVHQYGIKIKIIGNLSLLPANVQQVAYKVMEETKHHKGRILNICCPYTSRDEMTTAIKETVQSVKEGRLSIEQIDDETIQSHLFTSDCPPLDILLRTSGEIRLSDFLLWQASDGCQIQFVNCYWPELTLWKLLPVLLEYQIYSDHQQQAKNNSKMPMFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHL0</accession>
    <name>A0A367JHL0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001288">
        <property type="protein sequence ID" value="RCH89438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHL0"/>
    <dbReference type="OrthoDB" id="10329901at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="101" mass="11192" checksum="3F65AED74DF65DC1" modified="2018-11-07" version="1">MTTQNSISTSSSSIVHPCNLCSEQFDGADKLARHKWRKHVNAVQVIHEGITIVYSKTENEYICPIDKCNRTYKSANGFPSHLNAAHNASLSTVSKLTDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHR0</accession>
    <name>A0A367JHR0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001280">
        <property type="protein sequence ID" value="RCH89488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHR0"/>
    <dbReference type="STRING" id="86630.A0A367JHR0"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32631" checksum="4C89091AA9CF1463" modified="2018-11-07" version="1">MSTLVNRMLSQKDKLTMINHWLSSKEEEEQQQQQQQIYYNNTSPRYSIGIPPPPYENVVQQQPPMDRKKYSFSSMIWKRASFSSTVSSEVKIPVTTIDKKQVEHGITLLNIATDMNNNNSQPMAMDLYMMGLDKIMSALPLESDPNAKLALEKKIREIQQVHQLDLNSDMIQEQEEQEDEDKPIRKQLSNLIINAAVLGAVALKKSPIPDAVSGVVNYAVDSIQSIDEKHQIRKRTWDLAATGVNKAIQIDRQYEIHQLVSEAVYTGFAAFIKAGMAYAETPGYGQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHZ1</accession>
    <name>A0A367JHZ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001263">
        <property type="protein sequence ID" value="RCH89582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHZ1"/>
    <dbReference type="STRING" id="86630.A0A367JHZ1"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="1">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="198" mass="22997" checksum="A6CA77E367D97044" modified="2018-11-07" version="1">MSLDHSLESKKNKRIRYPQQSCIELNVTTYSVANKKITATERKRSKLCYSFTAQDLNIKDSPIQKPSFSGAIFYFKKVDSAIDLSSTVDLYAQYSTNHATLSTTRKKKKRSGFSTLFRRKEKRCTDTRFSMDTERAMYRLSYTKLTNPERSLHDQVIISNLMYWYLSVVARPHAPLSKIATCRIEQLNKTRKDVANRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIU3</accession>
    <name>A0A367JIU3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 31, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM31_1</name>
        <name evidence="10" type="ORF">CU097_009296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001216">
        <property type="protein sequence ID" value="RCH89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIU3"/>
    <dbReference type="STRING" id="86630.A0A367JIU3"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="688" mass="79575" checksum="63F3AA00DC118487" modified="2018-11-07" version="1">MPLSFLIRRYVSRSPHRLYLHTKKRKNFIFAPIIAYNFDYNCRHEVAATTPNMSLMSELCKNNNKIWLQHARRFHSSCIRQTQQQQQQRHVTKAELLAQARGFFERLKIRIKYPLMRQIRPWTLNDVTALFSWLFLGHTVWLLVGTTSFVSLILWTANSLQFQEWIAYRIGKYLTSATGATVVFESAIVPNWKDGKIRFNHVRIYRMPRSELEKFERHAALTNIGQAIPEEEQQKKVVVNEEDDPLAGVELADDEKDNEVLKKWMWYNLVIDRVEVSLSLIRWLDGKGLVQSADIQGVRGVVDRRHVRWDPDEPYDPVAARHKYTPGDFELEKFTIEDLLITVYQPNGFRPYPVSIFHAQLDRFRKQWLFYDILCATTITGSFDKCLFSVHSPQLEKSVLEQSGHIDSPTSGFRSHDIYHYYPFKGQDPNGVVVGGETEKFGVLTDDDMKKQGYKRKSRLRIDGVKIDHLNRGVEGPPGWITSGTVDICADIYIPQEAAEADSTELLRQLVYELTDSIDLPQPVILGAGNGELVVGGKQRESRKKPKEEDMNNKKFIMDVDFRFKDTKASVPLKTPELSYLNSAMVRPVVGYISRNKAIVPIKVRVVMDLSNFDGSWTVYDSTLAERLGEKLGQGFVDLTLDQQERNRRLKRIGFWSIKEMSRNLLYIHDMMRGTSRGFWSYLGTGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIW6</accession>
    <name>A0A367JIW6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001214">
        <property type="protein sequence ID" value="RCH89870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIW6"/>
    <dbReference type="STRING" id="86630.A0A367JIW6"/>
    <dbReference type="OrthoDB" id="2288411at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="258" mass="29424" checksum="8BACC3FB4D24065E" modified="2018-11-07" version="1">MKKMIKLQTTIKTNTAPWMDKVRKTTIKERKSAALKSSPSRPLADSASIELKCSDESIAKRVKQCAVADKVVEECEHANSSSEAVWRTEDFGWNIYSRTWTKVDDILQKHPHLNQKIIWQLVISVEDTNLESSAWYQRKFGLDSDFLRKTSSYSHHDLTLRMASPGMDPISEVIASEMSGLIFALPEANHRNSKEDMESYWNAYSARLEALVKQIEEYNPTARFPILICYFPVGEDAAITLQRISLALGLERHNTITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIY1</accession>
    <name>A0A367JIY1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001221">
        <property type="protein sequence ID" value="RCH89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIY1"/>
    <dbReference type="OrthoDB" id="2279666at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="183" mass="21284" checksum="CA8F79D875F64D2E" modified="2018-11-07" version="1">MDRGRTLTSFDKMERKITGRKMDLVFFRQRHEYGCCECSRYDGQTKELYDDGFKMVKVLKDILYNFYMKSLGALRDMTLVGFLLFDAKFTMVLCDTSAGYVCRINHACPVDLPEAARDVGNELLPMLKAVYQARLAMERTNKLVKQKPAEVCIEIEERDDILPSFTSEEYISKRRWSSPLVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLI7</accession>
    <name>A0A367JLI7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_000319</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001065">
        <property type="protein sequence ID" value="RCH90802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLI7"/>
    <dbReference type="STRING" id="86630.A0A367JLI7"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="48"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH90802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="181" mass="20947" checksum="7C9984DC27993195" modified="2018-11-07" version="1" fragment="single">MSHPYYPQDLFIPDYVPNLKSQLELFLIMGGVFVCLATVFYRLGKNSGSPLKFIWFMICGLLHCGFELYYALNVGHIASQNNLLAQLWKEYAKGDSRYVIYDPSLLALEIMTIIIYGPLCFLTAYTIWIKSNKQYFFQLVVSMCHLLSCSLYFLTELPDAAHCHPAYFWGYFLSMNAPWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM26</accession>
    <name>A0A367JM26_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIA large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TOA1</name>
        <name evidence="7" type="ORF">CU097_012241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001039">
        <property type="protein sequence ID" value="RCH90978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM26"/>
    <dbReference type="STRING" id="86630.A0A367JM26"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH90978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="346" mass="38925" checksum="52556991D057BB25" modified="2018-11-07" version="1">MSNAIVANVYRYVIDEVINQVRGDFEDMGIDESVLQELQRSWESKVARSRVANFGFIRDEPFYDDEHSDMPPPSSNGVHANDNVDNNSHPILQYPHNQDYNQNATSAPSVASLANLAASNSRLQQQQQQQQQQQQPNFGLPPPPRMIPDPSTLASPYHVMQPPLNNNNANPQNHQLPELQLPGIARRNLPQNDGACDELTTEEIDKHIEDIIQSSQTHSEEDTITFSATSFSGEPIALDSLPEHVKQLIKDVKGKTKKSNVKILQLDGEDDGEEGRGDDDINSDLDDTDDENEEGEGGEEIEHIILCLYDKVTRTKNKWKCVLKDGIMLVNGRDYLFHRATGDFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMD4</accession>
    <name>A0A367JMD4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CU097_007354</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001020">
        <property type="protein sequence ID" value="RCH91102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMD4"/>
    <dbReference type="STRING" id="86630.A0A367JMD4"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF45">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="16">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="YDG" evidence="18">
        <location>
            <begin position="223"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH91102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="579" mass="66538" checksum="E158AF0E0E6E9F20" modified="2018-11-07" version="1">MQVQILVPRQDKRLTLNVEEDETVSSLRKRIANLIELNKKDFLLISLGKILNDTCTDSQPALITSTYRIRDKTAVIVHINKTPGRVSPPVKRSLPKQEEKENKPRKEDVILDLNIVTAPYENFYCTRCNNKGKKCPECGCRQCLRKTGDPLICDQCDSYWHAQCAGLSKIPTAEYWYCPDCINTDVDLIIDKEKKVANVMSSLDNLIRIKENECNIVPHNHVGKIPGVYCGQTWNSLNLLTSWGVHRCMSFSTRVVGSYITGATSIMLYRNLSGLETFVDKGYEFIIAGRNITAKNEPDMLKKMLIRQDRALALTCDAPLNEKTGGTAYNWRNSRPIRVVRARNAARPPNDFEPEQGFRYDGIYKVVKYWPTILPNPDRVVWKFMLRRDDDELAPWLSKAEEEYKKKGLRMIHEDEKENKKLVKYKIPARIQKMMAEDKKNQRLWEGVKKLEFYSEYEFLNHLFENVVTCCSGACSKPIKNPAVTPCGHVCCIKCLKHTKTEACFVCRAPILRKDIKIDEDLVKILMALNPTYQAQTDKIPCPALGYEKTKRKRTTTTTTTTMKIKKPRKRLRVVIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JME6</accession>
    <name>A0A367JME6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CAPN7_2</name>
        <name evidence="9" type="ORF">CU097_012425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001021">
        <property type="protein sequence ID" value="RCH91097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JME6"/>
    <dbReference type="STRING" id="86630.A0A367JME6"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="264"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="451" mass="51708" checksum="A32B9C0A5C85B0CD" modified="2018-11-07" version="1" fragment="single">MHTLILQKSDNSSSRDLYKEAYIHACKAIQLDTSARYSEAKNAYSIVIKNFSTLLSFDDIDFDRQKLIQKLNEYKHRIEQLERYLGGIKPTRKNTSIYINENSPYQSRRDLFETDIERSIQDEWMEKAKFSFDQAELNEEKGNTEHALDYYSDAAELYLKAFKEYPNDTEEKLYARQEFMKAIDKAEQLKAQQQKATQFLSPRTRSSSSVSSTMDQLSNGSRRRSSSTSIQQQPTDDVMTQKLSASEIEVLKHTSSVNNNTFLPWIDETDLKEQFSYPTKFLDPMGSLALSEKQQEKFGGWKRPCDIMRHPKLICCISSTSIIQDIVTDCSFVASLCVAAAYEQKFKKQLITSCIYPQNKQGLPCYNPNGKYVVKLVYNGIARKVVVDDLLPVSREGTLMCTFSTTKGELWASIIEKAYMKLMGGYDFPGSNSGIDLHCLTGWIPEHIFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMX5</accession>
    <name>A0A367JMX5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000999">
        <property type="protein sequence ID" value="RCH91245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMX5"/>
    <dbReference type="STRING" id="86630.A0A367JMX5"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="194" mass="20638" checksum="E4E15DD62BB3BBCA" modified="2018-11-07" version="1" fragment="single">MVSAILSEGPQFRSEFKYGVEFKKTTTSEEVKENQTVVKLAAAAFNHRDIWILTGNYADIVLNSVLGSDGVGHIIKNGKIGQRVLINPAIGWISDPRKPEKTLHILGLLPAIGTLTEEPVTVDQEDVVPCPEHLSLAEAAALPLAGLTAYRALFTKGQVQKGQHVLITGIGGGVALFALQFAAAVGAHVYVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN03</accession>
    <name>A0A367JN03_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_005171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001023">
        <property type="protein sequence ID" value="RCH91081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN03"/>
    <dbReference type="OrthoDB" id="2282261at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="22096" checksum="D79C27F58CA12118" modified="2018-11-07" version="1">MKRISRAKFENLAYLLLNVVNITLYIMVLSGSILKASGGSLADIIQSIYCILICLLLVVHEIIAPTPYIQLYFGFLSLHRGKGLIMLFLGCLIMCEIVFNIIVAILVFTFGFAYIILSLSTLPPPHGFLIHWQNHKDFWAEGLDLNIPPPVLLSSPDHLTMPPSSHFLHPSAWHPASSKVAAPTTASSTPVCRNNLRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN78</accession>
    <name>A0A367JN78_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000982">
        <property type="protein sequence ID" value="RCH91345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN78"/>
    <dbReference type="STRING" id="86630.A0A367JN78"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77845" checksum="C29D111D9A661349" modified="2018-11-07" version="1">MSGGEPSAEQASPIPSKTTLNSATEQTRLLDSSGTNYNSGNSQTVITMAEQPYENGSNNASLSSGQPIVPVGELTEKIQDILVFNEIKKHQSMNRTANSKNRKAEKDSDSDSDSDSDSDSDDDDAHHLLKKKLSEWSLDRKPGTSKRLRKRDIAFDTLRFATDKWKIMHGWSPSHHESLSEANEVKITSTSVKPVGHGATIQHDRVQEYSQLPSSAESIFNVAKNASVCAILALLHERRQSSGHSTETDIFFQSLALTTLTLGIKAQGTSAKQVVLHEMLTVKWLNGKSALEWAVENNCQLILSDERVQTVIQELWESGPDWRQNQNHPSHIWLKPGSDGTARKSFAWLVITRTTTNFLARWPSPRYQAFVTLFSAFVYVGLHLATVTNLDYTSDTPFAFEYAYYVFVASDLLLELFALLSHPTIYLKKPSSYLSLTAVGLLTASAVTRFVALVIFDNFLDQHALLTTSFFLLIFATPLMFFRLLSSWSADRLSWNVAKANHIVTQCIVNSLWVFALSLLVIFSFWVTLGALQYDDIKPLNMLGLLTLGALHAPEIADTLYYQPATAGALFIAYLFITVIFLGSLLTASFLSTLLNVNKQMDSLKREWNIKRCLGINPTLSMLIPSAIVDLLFGFFLFIARRVFKCQRVTWIEKAHQVIWYIIYSPIILLVGLYELVIVLFKWKSVKIFTNRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNI6</accession>
    <name>A0A367JNI6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000971">
        <property type="protein sequence ID" value="RCH91429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNI6"/>
    <dbReference type="OrthoDB" id="2288255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="98" mass="11115" checksum="E280A8B8E86BEAA3" modified="2018-11-07" version="1">MRYDKLGSCEIGRDQVTEVDDKYLDDGRIKFLKTLRDILACLAKKNPSQVNSFATIGYFMVDIPVGNLICRVSQTDRYEFSQSIDTFALNFIPLLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP04</accession>
    <name>A0A367JP04_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000939">
        <property type="protein sequence ID" value="RCH91656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP04"/>
    <dbReference type="STRING" id="86630.A0A367JP04"/>
    <dbReference type="OrthoDB" id="2272461at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="464" mass="52086" checksum="7C83EF8232167003" modified="2018-11-07" version="1">MDSTSTSSTQPETVYVAPQQPEQPQQQPTVTTTLQEQQPQQQQQQPQQPSPPTSQDQEEECSILSPTLADILSDDRILRFYQCVKDIRTQNSPKQTAAMFFALCHALGDSVSFLKVPNMSKIMFRQEQQIFGVNVAGTQHDIFQSAVPPPPPEHNIPMAIADNTNTSLMHDVDSSHGTSNLFTATADNQHILQAALASVTAAAAAAASNSSVPDTISTKRRGQDLKGTTTKRTKKASPRDKEYVVRRNEIIQDLLKLSDVDLLHQANTIDPEVKLIIQGQERSTKLGALAPLHRFAAFANLPAHYDCDFAPKNAGVYFNYEYFQLYLAYRDLEIERQQQQQLEGSADHRPILVQCRADIEKVLVNTNWEAIRRRLTIGERIYQVCDILGRGFLLLSKQVSGRKLLHNFNAGEWAEFMREFRKPENQALLDNLQARYNPTRFYGQPQSKDAVITVAEVTPTPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP33</accession>
    <name>A0A367JP33_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-protein Rab6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB6_1</name>
        <name evidence="8" type="ORF">CU097_002538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000934">
        <property type="protein sequence ID" value="RCH91693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP33"/>
    <dbReference type="STRING" id="86630.A0A367JP33"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23261" checksum="C3F45692A9883CAB" modified="2018-11-07" version="1">MTSAEFSSPLRKYKLVFLGEQSVGKTSLITRFMYDTFDSTYQATIGIDFLSKTMYLEDKTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIVYDISSRNSFLNTTKWIDDVRAERGDEAIVVLVGNKTDLNEKREVTTEEGEKRAKELNVMFIETSAKAGHNVKLLFRKIAQALPGISGYHNSIGSEKDQMQKVNLNSSNSEASGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP69</accession>
    <name>A0A367JP69_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Surfeit locus protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000927">
        <property type="protein sequence ID" value="RCH91742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP69"/>
    <dbReference type="STRING" id="86630.A0A367JP69"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH91742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15209" checksum="8C2A302FF02F478A" modified="2018-11-07" version="1" fragment="single">RKQMFAALPQISETNRRMYIQLAGRILLIFLFIGSAFHGDWSLIRIVVSLFGLAACVMVAVGFKAKWSAMFLVLFLSVLNVFVNNFWSVQHSYYKRDFLRYDFFQSLSTVGGFLLLVSTGPGGLSYDEKKKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPD8</accession>
    <name>A0A367JPD8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000952">
        <property type="protein sequence ID" value="RCH91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPD8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="111" mass="12961" checksum="D93034BAC917ECC6" modified="2018-11-07" version="1">MPLIGLRIQCTLFQILEDIILASERILERMVGEFDGTEIAQSECKESDDNRTAKRFAWSWHEVTKGMMPAIKSVLGLKDEQDEEKFLVDLWYLLRADNYDYIVYAVLSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPH6</accession>
    <name>A0A367JPH6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000948">
        <property type="protein sequence ID" value="RCH91591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPH6"/>
    <dbReference type="OrthoDB" id="2285112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="36891" checksum="2746DDC1B321F9F2" modified="2018-11-07" version="1" fragment="single">MSLEDVSVSLSRLALAKAIKTPDTDEIEAEPWSKSVIFHQSHITDDMKNSIMNPQSIKKGRKYMPRQPKPSPQYPQQLYPQQQQLQQQPYPQQHHLPAPMNRTRSSDRPQSSSSSSISSNNKSSVIMHSAITKNNRRFVPSDDEEEEEEEDEEESESEGEEQEPKTVINRQPQTPKPDMKPLSTTSTSTGAPKLDINIPPPEIVIGNSNNKEKGKAPKRTIQPSDDEDSEEEEEQDDEEEEEEEEEEEEEEEEKKVEKVEHKEHEQHMYERRMSTLKQLERGPSVHRRARSTGDVIQEVQQQQQQQHPIEQWRMSVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPK2</accession>
    <name>A0A367JPK2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1740-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_003221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000916">
        <property type="protein sequence ID" value="RCH91815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPK2"/>
    <dbReference type="STRING" id="86630.A0A367JPK2"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1060" mass="124314" checksum="FC7B99EB3FF6BC5D" modified="2018-11-07" version="1">MDPSRKIPPPPSFQSAPDLSKSSFNIPSFSSAPDVFNKETNSSKSAHKEHKRRSRRSRSRSPSHRKSRYRSRSPKRSRSRERSYRKESRRSRRSPSKEREPLHSGELKTGFTFIIDKRGDPELSFYGGTHSYSVPAFRRSGYGRVLGFNWNERLIVNQGKLELVDILSSKPARYTDSEYAWKEIDKSLKRIRIKKQENDQDPFSLSSGYVQLSDDHQKKKKADYESLVSTGVDYRSLEGNKVRAVREEDEEEEEGESYNDIIRRRTVEYNQKLDKEPENVDLWLEFIRFQDEAAEGLDASATKSNQSSLNEVKLSIFEKALMYNPKDERLILAYLACGATIWDTLTLLREWDKQLKLYPDSIKLWSEYINTRQTSFSSFSFTECIKVFEDALSILKRQLDRTKHREEREDIECLIVYIILRTCLLMKQSGYIERAYSVLQAIVEYNLFAPAGIQDKLGAFMEFWDNEVPRFGEKEAQGWNAYYNTKADYEHRPEEEENVEIINLQDWARHEIEADQKHRLPVRMTQIDDENVDEDPYRVTLFDDIQPFLFEFTTFAARQTLIYSIFVFLGLNYTPPNIGTNTHFFTDTFTHNDLPLDKFWPENSNKQSCLVWYVSGVPMEPEQAVTENDPFSIPPSYPVGLSELFAQPQHWFCSSKTEYNKVDREFTKCAFEQLLKLERSMHLTLCYLSFESNYEYKAGRKLAKSLLKDDRTNLVLWTAYAQMEKSHNKIDEARKVYMTALSTYRSFSESEQLAAPLMYQMFAKLEMENGRPAEALKILVSMSGDKPYDVNMPLPTATLILRAREYFAQKTLQLSVLSEMESEMQAGINMGVCSALFEYLSSGLENACKVFDRTLDYIKERKAERGYVSELVMTEYANLLYQHAKYHQLEGGFQPRMMRERMEQAIQLFPNNTMFFSFYIWNESRAKVFNRVQALFNTALSKESNVVLWLSAIYNELHRYKPYQANLVRDLFERSIQDINTKSSIILWKCYIKFELLQRNIERAKGLFYRSLRECPWSKELYIIGIEQFEKIMDDKELNELASLMLEKEIRLRTPITDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPM3</accession>
    <name>A0A367JPM3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000906">
        <property type="protein sequence ID" value="RCH91892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPM3"/>
    <dbReference type="STRING" id="86630.A0A367JPM3"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="5">
        <location>
            <begin position="251"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="595" mass="67073" checksum="9CFE8CBA0973C11B" modified="2018-11-07" version="1">MSLARNLVDLYVLTSAVSKVSASALASQASSVCQHVKTSSLLNPTPMIKEVQTENSPERQQQQQQQQQEMIEVPFNNLAVQDNTTSIPTASDTVAQAQTTITNTKQMSEISINKQQHLVEDAKVDLVIKETRVDPLIEKPAEPQIPETRRQLKESRIPTSRLSRLWNYGTLATSMGLGAMNESLKRATGISNQSSGSVLLSESNVNRLVEKLSRMRGAALKMGQMLSIQGIQSASDKSSGLPPQLEQVLLRVHDSANYMPRKQMEQVMTNELGSDWKTYFKDFDPVPIAAASIGQVHAATLASNDQPVVIKIQYPGVAESIDSDLSSLKALVTFSNILPRGLYLDNTIRVTKEELAWECDYEREADNAIKFKKLLEGDNRYKVPTVYKDISTKRVLVSERLFGRVLSKATEESQELRNQLGERLLRLCLREVFSFRFMQTDPNWSNFFYNKNQIELLDFGACREYSKDFLNKYGRILLSAANNDREGVWKYSEELGFVTGYETEVMRNAHIDSVMVLGEPFRKTAPDVFDFSSQTITGRVRETIPVMLRHRLTPPPDETYGLHKKLSGAFLLCTKLGSKFDTKAVWKEEVEGRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSG8</accession>
    <name>A0A367JSG8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BRF1_2</name>
        <name evidence="13" type="ORF">CU097_011867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000764">
        <property type="protein sequence ID" value="RCH92912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSG8"/>
    <dbReference type="STRING" id="86630.A0A367JSG8"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="85"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="179"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH92912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="679" mass="76738" checksum="548BCFDE87E2F2A6" modified="2018-11-07" version="1">MRCSNCGSNRTESDAASGTSYCIDCGTVLEENTIVAEVTFGETSGGRAILQGSFAGDSGRIAGGGLFGRNRGREGQEQALENGRQKIASLAHGLRLPERYREAAQRYYNLAVVNRFTRGRRSEHVAAVCLYAVCRSEKSAHMLIDFSDILQVNVFTLGATFLKLCRVLNLNLPHVDPSFYVSRFAVALDFGDYTQKVAQDAVRIAQRMDRDWIVTGRRPAGICGACLLIAARMNGFRRTLREMIYVVKVAEVTIQKRLNEFNQTESSKLSIRDFRTIWLEKRADPPSFQKNRMKEAALQSISKAEDGKEDKLEIDTETDGDKTVKVVSIDKNSDKYTESQLNITEEDSSTQVDIKDDLPSIPDLIKDSQNLDESQTQIATQISVLDEEAHISTLVDQLGDKDASYVNIKNSPAFNDLPPEEKMKIIKAAREKVAGEMEVMLNPNLAEDAKEISKDLEKWMQDESVNKAAKELEKANNKKEGKDEEEEEEEEEEEEENLSDVDCDEIEAMILTEEEVALKTKIWYNANKEYLEEMAVRRMVEKDRGKDHRKKGGTRKRKPISSASTPAEAAKQLVAAKKVSKKINQAVFDDMFESPESIEKIKQDSLKRKADDVDLDGYEVVEESGELPQAKVRKTDKDEEQDEDEEEDEEEEMVAPYGGYEQDHYDYEDNYYDYGDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSW9</accession>
    <name>A0A367JSW9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000760">
        <property type="protein sequence ID" value="RCH92949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSW9"/>
    <dbReference type="STRING" id="86630.A0A367JSW9"/>
    <dbReference type="OrthoDB" id="2363417at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40892" checksum="1B33EA375EC3EC5D" modified="2018-11-07" version="1" fragment="single">QDFTLNTAINSWQSISSPDFVLEPNSLFSIISLNHSYLIHGGLGYGSSQQYKKNITVLFDTTNLSWTTIADNKTLPSREGSATLDTLGHAWFWGGLSDNTSSPNITTTIYHNELTVLNTQNFTWSFPNNQTNSTSKVPSFVRPRLEHTATLTQSGNSIYFIGGLEVTEDDTIVPAAMDEILEFDLINSTWKMHKTSNKTVPSHRRLHSATEIPNSDLILMYGGSFTDSPKVVSDYIYLLNTTSFEWSMVNITNSDQGAGPRFGHSAVLYKNHSLFIIFGVDTFGLARNDFFLLDVGNWQWVTGFKTNDVYQATVVPSSSSKSVEPKPAATGSTVQQGSATSDGSKRVGHIYSIVIPLLAFFPLFFESFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT11</accession>
    <name>A0A367JT11_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IML1_1</name>
        <name evidence="9" type="ORF">CU097_001032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000742">
        <property type="protein sequence ID" value="RCH93094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JT11"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1560" mass="179781" checksum="DD13F6A2A85B5D44" modified="2018-11-07" version="1">MPPKGFLLSNKPIVLWIHDLGLTHHNDAIVNPEIFPNFRDGQLLRIHCPPEQEKDQQTQEQEATEYVIVKGYAPDKESLTKQLQLSISKDLADRFNLRSRQEVYVELIDPTSVSVDHIELAFKEQYLSRSDMWRLQQSLKSTCAYLEKKILFAGSIKATVKRMFRARQEITSGYITEHTRLIFRSASAKYFLFIQMSKEMWEFDEDGELYFEKAVSNFLPQLFSRWKEEGANHVVSIVLFTRVFYEAHNGDPLLNKAEDGRYYKDFYKVLADWETSDDWMSIIGQLKKEQANFQPTVLLRSEPDGRQVMSGQISMAFEGNVLEAINLALNPFDKHYVDRDLMRTGLSIILITPGVGKFSVNKKLLRLTNERMTDNGIAMDLVCLSPLPLHITPLMYYMDAPLAIDENENRKQFTNFGASPEKSATTTKVLGYMDPLYQDNDDKPTKKYFNVPHWIDCSFYHHETGRFLKQDKFKTRCKMYELQMMGIMEHDLKGISVPYLSEHQKSIRPQKSSSSLTEKMTSSHEETTNYLSRSANISTSVRRSSFLAANSEITSSYSRRAYETYDASLFKSTPEPRFYKKPVSATKMIKTFHNAKSPEDSPEKLENANEFWKNASNRHKSTTTWHYTGEQRRIPSIISQSMGTKGPLDRKEELKGSEPSPTYAKDDRFRSLRRGTVNSTDGKYASVSMNLPFDRGEDDDAVVVSSSTVDPVPIKLRGDMNNRTSTTTNKTNHSPRSLSSIHKQSGNSDLVLRTSVNRSSPSHTLNRTCKYILINPCNPSDNPNLFTSHLRRWQHALPKAASFDGPVVHWRSLVTPACLPLTTDYFPSNEELAARYNHYMYTVSASEDANLYQAGDQNLSEHKKTENLLIEMLSQRLAQGFQIIVDITGSSQGTKPKESAAPISALGGSLLGKDKDVRSSNNTISSGTTAMSNAKLAQTGVISTDQQQQQQQYQQEEGEKMKWKHMVWWLSMGHQVHQLTFDSSGQNVEVRRYVRIIDFDINKINYQCAIWPKNMPMYRSKSVTFNYPSLLYAWNYLDHLVAGYQEELTDNLRFWRARFILIPRETLPTNITFPAALHDHLDEEEKRIALFELWVQNMRKAKWLSPEEREELQKKRKREISDLGIRLTTMDPSAYVASDAVRTNPTSLPESKSHWFTVLTKESKTKDIAAAMQDPRGGLKIMDRRWHFKMYHDVFTGSECVDWLISQLEDITTREQAVQFGNSLMQRKPPLFVSATKRHSFLDGNYFYTLHEEFAVDKKKSKTTTTSRKTHHMNENNQELKQIPSQSSTTTSNKRVDFHMSQSMIIDVDPYKKSDRRETAILHYDIIHNPKNCYHFQINWLGCTAQLIQELVQNWGRQAERCGLKLVEGSVEQAYEDSENDNPFQCPVPIPLAVSPPSVEELMTAAKIDVPTQFYEIALVRHLDFVLDVEADLKFAKAEHVDLQYSYIKDVYKYDQYIHRSGVAFVQIRPNNEGFFWVNNRLHANHTPALSRRQTNAQHPDTLRIKFQEHCSDVQWLTEFWETTRAHFLQGVSEHAAWVYENSSAIVETTEHDFEDNITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTV2</accession>
    <name>A0A367JTV2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_010994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000704">
        <property type="protein sequence ID" value="RCH93394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JTV2"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1259"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="657"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1285" mass="145766" checksum="AAF4D9DADB6157C4" modified="2018-11-07" version="1">MLLVLGRPGSGCSTFLKVIANLRKQYTRIEGDISYGGIDSKTFLKRYRGQVCYNGEEDQHYSMLTTKQTLEFALKTKTPGQRAREQTKSDFVNRILYLLGNMLGLTRQLDTMVGNASLGGLSGGERKRLSIAEQMTTHCTINCWDCSTRGLDAASALDYVRSLRLMTDIFSITTIATLYQASNNIYNLFDKVLVLDKGYCIYYGPVNAAKSYFESLGFYCPPRKSIPEFMTGLCNIAEREVRPGFESIVPRHPSEFQEYYYRSAIYQLMMDDLNDYKETIQKENKASVFEHTVREEHQKYAPKRFPYIASFFQQVKALTIRHHYLLASDKKTLFFRYGMIILQAIVNAGCFFKLPLTPHGAFSRGGALFSCILCNTFISQTELLNFMVGRPVLEKHRQYALYSPSAFYIAQVITDIPYVIFQVFLFECCTYFTIGLSLSFSQISTFFVGLFVLNMSMNGFFRFSSTITSSFFVASQLSSFNLIGNCAYTGYTLAYNKMRPWFTWVYYQDPLSYTYKMLISNEMSGQIFSCEGARESVPYGPGYDDWRYKVCAMKGAKPGIPYVRGDDYLLEAFDYKASDKWFPTFVIIIGIFLFYTLNIIITMELGGKNRSGYLTKLYLPGTAPGRNRKTKCICRFACRCGNSAADSIKQASTDTIFSWQNVNYTLQLGESSLQLLSDVCGIVKPGQLTAIMGSSGAGKTVLLDVLARRKTTGEVKGRVYLNGDILLDDFERITGYCEQIDMHQPKATVREALRFSACLRQPANVSKEEKYDYVEQIIELLELEDIADAQIGEVETGYGISLEERKRLSIGVELVSKPQLLFLDEPTSGLDAQSSYNIIRFIRKLADAGWPVLCSIHQPSLMLFEQFDRMLLLVRGGRTAYFGEIGQDARTMIDYFERHGAPKCLPDTNPAEYILDVVGAGTSVKTAGQDWADIWQRSDEAKALTTELDEVHACANKCPTRKTQKYAISFITQLRLVLGRMSTVYWRSPDYNIGRFINLMATSLACGFTFWKLGNSISDLFYKAFALFITFIMALTLIILAQLKFMGERLYFRREYASGYYGWLPFGISVILVEIPYVLVLVTAYMCGFYWSAGMTNTAESCAYFFAILLVLVCWAITIGFAIAATVELPMTAAMINPVLISILISFCGLMQTAPSMPQVWKSWMYWVNPFHYYVEGLAVNELEKLKVECAEDDLLRFFPPPNQTCGEYTKGFLSLATGYIVNPEATQPELCSYCAYSSGAEYYETNMEWSADNKWRNLSILGFFVVLNIVMFLFAVYLKRKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU14</accession>
    <name>A0A367JU14_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AMS1_1</name>
        <name evidence="10" type="ORF">CU097_001917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000701">
        <property type="protein sequence ID" value="RCH93406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU14"/>
    <dbReference type="STRING" id="86630.A0A367JU14"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH93406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="710" mass="80418" checksum="B0F30D5E83EF6FF0" modified="2018-11-07" version="1" fragment="single">MLLGQRFFEKHFGKRARVFWLPDSFGYSAQLPQVLKQSGCDYFFTQKLSWNNINKFPLTTFWWTGIDETKILAHLTPAETYTASVTPAELYKCTRNNHDLERSNHSLLVYGHGDGGGGPTTGMLERLKRMKSVDGLPKTSPGSAIQFFTDLEKDANRLQAYKGELYLEFHRGTYTTQALVKRGNRKGEVIIHDVELLATMAKIHSNHTNGDYSYPSNEITNLWKLLCLNQFHDCLPGSAIKLAYVDVHKFHREVLSKSLNLRHDAQSFLISQKPKKDQQESQQGIIAFNTLPWPRKEVIVAPQKGTKWSNQQWNKDGYEYLIVDGVPGFGAAGYLASSADFANVSADKAAKAYATKSGYFVLENPILKATFNKNGQLIELIDKRTSRGNLVPNKCRGNVFQLYEDVPTYWDAWDVEIYHLQKYVDLEDHGHIEVLTEGPLKAELLLVHKISDVSSIKQVISLTCIGERLEFDNVVDWHESHQFLKVEFNWDIVSDYATYDIQYGVVRRPTHYNTTIDSARFEVCGHKFTDLSEANYGVALMTDCKYGYATHEKTQRLSLLRSPKGPDEDADMGQHKFKYAIYPHIGNFSVSNVMQSALEFNTPISIRNGDGTEVCSGEMISSLFYLEPSREIIIDTVKLAEDDQGQGNQVILRLYEAYGGKSTAVLKSSLNIKKIQISNVLEDDTGETLEQNLNGDFTVTLKPFQILTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUN1</accession>
    <name>A0A367JUN1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRPS5_1</name>
        <name evidence="11" type="ORF">CU097_012971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000667">
        <property type="protein sequence ID" value="RCH93692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUN1"/>
    <dbReference type="STRING" id="86630.A0A367JUN1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="260" mass="28925" checksum="AC2C4BB3C6C63499" modified="2018-11-07" version="1">MLALGRSFAKLSVIPTARITATRAYATVGDKKLRHPALNKDNVPDLSKIDYILDHPTEKPSTLEQQKTFTPHRPPEVVMNTVTDIIDTPLSASEQARLMKKALVVKRVVNMNGKGKQPSMYALVVVGNGNGLAGYGEGKDEEAARAVRKATNRAIKNMRYFERYDNRTLPMDLTHKFHATTLELRARPPGFGIRTNHYVHEICKCIGFQDISAKVRGSTTPMNVIKAAFEALSNIKQPEDIARMRGKKLADVQHVYFGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV77</accession>
    <name>A0A367JV77_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_013506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000654">
        <property type="protein sequence ID" value="RCH93805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV77"/>
    <dbReference type="STRING" id="86630.A0A367JV77"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="9">
        <location>
            <begin position="207"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="696" mass="77435" checksum="5BEB3CAF9022DC84" modified="2018-11-07" version="1" fragment="single">MTASEETLVELTQQHLDPSNPFAFSPEQLYSIVYHKRLDILESIGGIDGLARGLHSNTNTGLDWREENLCYIRLHDLKQPPTKDEYYMPPDKLLYSDKEEYFVQRIKVFGPNRLPELEPVSLLKIMWEAYQDKTLLLLTASAIISLTVGIYEDLTIVEYDALGNRVPGVKWVEGVAIVIAVSLVVIVSSVNDYQKEKQFRDLNAKKEDRQVTAIRSGEHVLLSVYDVQVGDVLQLEPGDIVCADGVFIQGHNLKCDESPLTGESDAVRKLPWNECHTSFEDEDTTRPLDPFLISGSRILEGICTYMVTAVGPYSFHGRTMMALRTKDENTPLQDKLDILASSIAKFGLSSAAFLFTMLIVRCVIGYATGSLSTVPSDVVAHIMAILITTVTVIVVAVPEGLPLAVTLALAFATQRMLKDNNLVRVLAACETMGSATTICSDKTGTLTENKMSVVAGTLGSSFRFLKDPPKSRPDLFGVHELRTKVPLVIRQYLNQALALNSTVFSHQQTLVGNKTETALLNFSRNHLDSEPFELLRMRWPIEVVFPFSSSRKAMATVIRVSKQKGVIYRMHIKGASEVLLSRCSRIVSMHDTSYDQDASEIVTRVMTDANRERMVKIIQSYATRCLRTLAICYQDMDHWTADQQLEDVLQQGQLTLLGIVGIEDPLREGVTDAVAACQRAGVCVRMVTGDNMMTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVI7</accession>
    <name>A0A367JVI7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_005415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000636">
        <property type="protein sequence ID" value="RCH93953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVI7"/>
    <dbReference type="STRING" id="86630.A0A367JVI7"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="4">
        <location>
            <begin position="319"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="835"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="870"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="954" mass="107010" checksum="DBA9CC7D53F8A044" modified="2018-11-07" version="1">MYGAKATSTIINTVARQGVLTKQLTAPKSAAFLTQLPTRHVSAGKISYTTTSRSTHFSQKSVQHNQENQQQQQQQLDESLILQGQLRTAWKHKRPPLTDPAQVDGRILQAAKENDLHTVISTFTQGKSLSGAPLSSQTYEAVIEAYGKLRRQNQPLTPMMDAYRQMIASGARPSSHTYALLIRSLCTRDSEVQKTVGMLRRQMARTGNAVDNLSDLENEKNMEQALDLFEKAVKEKCTQDFDVDLYNRMLQNLSFKGNTERGIYILKHLEGDGNAKPNGVTFATLLSLFGVAGDLPAVRECFLEYKSLERELPSHDPAYVYNALVSAYVNAGDLDGALNIVQNVMTNDGIKVSIVPYNKIFRRACVDNKLDLVESILAALENDSKLPKPNGSTYAVVLSAYARKKDFDKAAQVYSKLLKCDISKEYGHLADYAYACIGNNKPEIAIQVVQDMVTHGLRLDLTLCQKLFASFVNNGKLEDAISSYQKTMDAYAQTHFVDKSSPIASLGLELALKCTNLKQALEVLEILKKYSVGPNPVVSSTIYNMYKKAKSNSTEWETISKDLSPLSFTVLYDAIFRKQSIPDDFCKTAFELLEDMLSLGISPTPSLYIRVLARMQKYGVPAEYEERWNRLFGPYIPPLPENINSQQDTESSNTSDNMNNSTQESSTNKIEPINKVTVESEMLSGKALSKALEGKYDEAIDILQNQIIQKGHIPSPDVIRDIIQVCTKYKDLGAINKIYSTVIESVQKLEHHTRQRGLHTIYNAMLVSNARLSSIDQAKAFYSKIRDLNMYPTGDAYGCLLQHLQPNDSEDSMDNLAADAMTIYEEAKKNKVEPTVYMYNVILSKLAKAQRLDSVLTLFNEMRQVGIVPNSVTYGSVISACVRCQNEELAVKYFNEMTVSPGYKPRAGPFTLMIQFYMQNQNREMALYYYNLAKQQRLNISDQVHGMFQQEMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVJ3</accession>
    <name>A0A367JVJ3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000629">
        <property type="protein sequence ID" value="RCH94012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVJ3"/>
    <dbReference type="OrthoDB" id="2221171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13743" checksum="7343202EAE08FE9C" modified="2018-11-07" version="1">MEQTPTSQLKNKLRQYARNTIKDKTVAQWNTNSLTAVGIDPDKFTAHSIRAATSTYAVQQGASIQEVKIHANWTTSRLQEVFVGPQVNITPTEFTVDSTKVFFAIRRSVNLQGSVQFLSSIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW16</accession>
    <name>A0A367JW16_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Grainyhead-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GRHL1_4</name>
        <name evidence="3" type="ORF">CU097_010276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000613">
        <property type="protein sequence ID" value="RCH94136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW16"/>
    <dbReference type="STRING" id="86630.A0A367JW16"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="2">
        <location>
            <begin position="255"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="696" mass="78967" checksum="495EFB11EA412EB3" modified="2018-11-07" version="1">MSFGLSHLRQQSQEDFCYDIMPLDIGLNEMERNTTSSYPSIHPDLPAFHNPTYSDWLVNKSRHSFILESNPPLYPSTPTAYPIYSNANTLTSSTSPYHSNFSEPSQSSPTLFWTAPTTNSTLFTTDIASSENTPTSAKISCSSSSEVIFDSAEAEIDERDSDSRNPSFDQQFMNVYRSQPKPTEDAYYNNRISKVHSRFKSANACLSSYGEKPKQEKFQQFLSPPLPSSSLMQSGQPLAESNNTLTVGSKRLSKSPFQFHAVLHSPTAMMKKEDQKPITYLNRGQSYLLELSASNQQRGTLTSTISIAFHESSHRRVAASYWRFWMSQQMNPESARAIGLDENQTTGIYNITYPSFDKVTFDWHGRFGAKVYIRFHCLSTDFSRIKGVKGIPLRAVVKTVTRYDHLPDNASSYSGSFSKIQHKSNDSTEGRYEYIERCYCQIKLFRDKGAERKNKDDSKQINKQMEKAIALTLGHPEQHPLWPIINQPYKPVTVLNEVPTSPDIELHDDFQQDIASPSVLYPCAIIESTSPEQEEPMPSTTSSSSSSSRKKRKQMDALEKVQETTVGLSSPQFIEPSSHLLKKHRAVADTLNFYVWSKRQFPSSGPNRVTLESLTAEELKLKLATILSLHPSRVSEILWKRKKPEILCGKESEKKNNDMLVLVEDNFVAEHISDEEIICVDWEIKSDSYVRLILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWA4</accession>
    <name>A0A367JWA4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THUMP domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">THUMPD3_2</name>
        <name evidence="2" type="ORF">CU097_012195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000608">
        <property type="protein sequence ID" value="RCH94178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWA4"/>
    <dbReference type="STRING" id="86630.A0A367JWA4"/>
    <dbReference type="OrthoDB" id="47730at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF13">
        <property type="entry name" value="TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="1">
        <location>
            <begin position="204"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="44063" checksum="DEA35D8A241F3E18" modified="2018-11-07" version="1">MTSNIHALFHVPEGLEHVAARDIEESIKDKSILQESTYNWEKKTGRVHLFGTVKGVSEFRSYIQEVELRSVYSVMLVAAETIIPIDTFNEADPTCQFISHITQNGNWETLFGKQAERATFRATFKKGALKHKVPSQEIAGYIGAAFGELYDEWKVKMTGFDYEIMGIWFQSDNVEWLKRLSVSDQSIILLLGLNIPIEDQKYRNRLFFGRTSLNPCIAYCLAMIAQPRPGQIVLDMCCGTGTIPIEGASRFPNTFWLGGEVKVKTLAEKGRGNVLHANLQNVDLLLSDGRKMCLRDGTVDTIVSDWPWGLRENSFQQIQGLYPKFMKQMWRVLQPKGKAYIVTQGNKLMHRVLKYDWCQRQWKVDDIVPIGIGGYDVYLFILSKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWI0</accession>
    <name>A0A367JWI0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ELP5_2</name>
        <name evidence="10" type="ORF">CU097_010446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000602">
        <property type="protein sequence ID" value="RCH94219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWI0"/>
    <dbReference type="STRING" id="86630.A0A367JWI0"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH94219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="38079" checksum="9162D749E28C190D" modified="2018-11-07" version="1">MNTLCLEQILKNKSSSFILINDTVRLSSLPILVNIGKRALGDNKSLVVLLTETSPKTWKKQFGETDDMYIIDCYTDPYGWDNTTDSDCSLLVNDITDIENSILLPLIKKVTKSAQCTILVDSLVPLFMISQFKTYQLVKTLETLTTDTTHLAIGHHSDIKLPTLSGISIQESINRLATAIIRLEALKERTHFDTQVALTGFTPQDTFSYLTTTSNALSKGGLAHIEWRKKSGKVTFETNGFIVKNGVLQVVSASQLTGVSATEQKSEDMEIDKQPDPTANLSFNLSLTDEQRRAKESLVLPFMKAQQLEVEEQKKQESVIYYDPDAADDFDDEDPDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWI7</accession>
    <name>A0A367JWI7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000597">
        <property type="protein sequence ID" value="RCH94268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWI7"/>
    <dbReference type="OrthoDB" id="10326991at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="199" mass="23700" checksum="F26855FDA5EE793F" modified="2018-11-07" version="1">MSDKENKNEPVEIPSTLETGRRARSPDLLEERNVVLLNKSDESRTESKRNDATVKKDTYLKELEPLKLKHRPGKEKIKEKEQEEELTDELYKLQEELKSQKEYYQLLDTEYKKLKKELNERSKEEIEASIEKIRSEYEEYKEIVKELDQTLDSLNQEGLSIVDLLDKKDQEIARLEKELLKVESDYFKYKYETSSESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY69</accession>
    <name>A0A367JY69_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000534">
        <property type="protein sequence ID" value="RCH94839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY69"/>
    <dbReference type="STRING" id="86630.A0A367JY69"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38529" checksum="EF4EE9AB7DD440E3" modified="2018-11-07" version="1">MCPALSPRPAPTSAHDLRPDDIKVIGALGDSITAGFGIMGINLSQPPSLAAFNALNEYRGLSYSIGGDEGALTVPNYVKHYQPNLKGYSIDSHIALYCSVHSCPGRYIPEKDRLNAALSGSLSINLQHQLDYLIPEMHNIAGIDFQNDWKMINIQIGSNDMCSSCDSRYMNITTPDQFASHMDAAIERIVTNVPRVLVNVIGAFNVSQLFPVTAGQAYCRPTHNDTSTIGNRRECTCGSTPDGLKHMDYLAVEYNKRLFGIYQKYQQNKNDSFAVVYQHSNLNMTSFPINFFSNIDCFHPGLVGHQWVSKIVWNELFQPQAKKASVFNFNANQTIYCPTDSDRIATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYX7</accession>
    <name>A0A367JYX7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000501">
        <property type="protein sequence ID" value="RCH95107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYX7"/>
    <dbReference type="STRING" id="86630.A0A367JYX7"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="58"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="181" mass="20856" checksum="B9C044FAD70FB665" modified="2018-11-07" version="1">MIQQPPTFNFIITRPHNKPANTCTRKGLPSILIDFTAMTLCDLLPAHPKNASIRRSLPELVFFVQKVTHQADINCRTLLVALIYLQRAKSNLPKRAVGSDDTNHRMFLGALLLASKFLKDSAWTTHTLTNRRLYEICGGLFSMKEIYQLERAFLKLIQYNCWVDDQDLNQFVLKHRQDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0H0</accession>
    <name>A0A367K0H0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000444">
        <property type="protein sequence ID" value="RCH95668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0H0"/>
    <dbReference type="OrthoDB" id="5596610at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10809" checksum="9D744674EC0A9E9C" modified="2018-11-07" version="1">MKKVQFSGNVEFVSTFANEDYDRTAQEVAKLTYRDMLELLTMKSQWKRDMERMLAEREMKEKMNEANNNQSQQQQQEQHQPLYNVPEICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1B0</accession>
    <name>A0A367K1B0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SET domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SETD4_1</name>
        <name evidence="5" type="ORF">CU097_003478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000418">
        <property type="protein sequence ID" value="RCH95929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1B0"/>
    <dbReference type="STRING" id="86630.A0A367K1B0"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="375" mass="43356" checksum="A49C1AE1EB7008A8" modified="2018-11-07" version="1">MATEDIEAGEVIVSVPNNFLITDESLIKLYGPHSLSSHQMLALHLVLLSRDKQSWWKPYVDLLPIHFNTMPAKYPKILFDHLPASLKEEVQQQRENIHADYLTCQKFLKSKFPTQQEMSIKEFEWAWLCVNTRCIHMTRSDHSLNGGSIALAPMLDFLNHTTEAKTESGFNVRTQCFEIRTMTPYKKGEQVFINYGPHDNLAMLREYGFVLKENSYNFVLLDKEVWSLYSELESKRGLAIKKEILEGSGYAGDYSVKKGEVSFRLMAALRLLALNGTTEPGFDRRVMDWHDVVMGQDDMISVDNERRAYIMLQSICKRVAKQAKDELEFLSTISKTHPQEEIHPFALYFSIQIWKESLDIVEQALDYLSDKLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2P4</accession>
    <name>A0A367K2P4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PHD finger protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PHF10</name>
        <name evidence="13" type="ORF">CU097_009919</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000365">
        <property type="protein sequence ID" value="RCH96474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2P4"/>
    <dbReference type="STRING" id="86630.A0A367K2P4"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="507"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="573"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="668"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="671"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH96474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="791" mass="89197" checksum="DDE434089A194AD4" modified="2018-11-07" version="1">MSPKEVKRKRGRPPATSPPASPKRLSSRASSTDYDAKRRREKSPLKLEQENEDELSENDEVGETKIDKNGKLLGGREYKVPTFKLPEYGDQELMLAMDPSKLLGYRDSYLFFQRNPTLKRVRISEEEKNMLVKMGLLVAWFKGREVAVVTARSVFKRFGSKIVKNGKRVVDDYFENRQEMEEDNHQPLDEANEMSAVGHHEYHFNEAALDNRNWIYHAALATRGFNAQLQERRTTRSSFYDIHSDVNQVPLGYQPRSCRFEFIKNKDYNQESVIEYRSVSDDKHAGFRGVGKDILDYNLDEALKTLPEEERNNVSNVLQEKPPIASIKEDADENYPLAIMDGQFQYAFPIHQARFNYPIPKIPEPSIIFDTAQSLSAQQYYLGVVYHTVNQFADPRRQPAPARPTPNVYIPPNAQPHPQQQQQQQQQQRITTAQPAPAMNMQQPIPQQPQQPMQQPAGACSFKISLTQTCGRPVNHPGQFCQLHSNAPKSMAETAKAPPPPAANYLGNTCTDCHQVAAADTLYTTAKKERITDPETLVKCSNCTRKYHPICANLTTPKQVAAVESYAWLCPECKICAVCKTVGDESTLMICDGCDRGWHTGCCTPKVEHIPEGEWLCQLCAKCHGCSEQGMKDECQYTHATAPKDDKHKYPVYLATYCRSCITNFNEDRFCPVCLKTYSEEENDEEDNEMVACDTCDHWVHTRCDESLSPARYQMLCDDESAKYSCPICENRVKPIVDTDAARNALKGVTAPGGTCIGLLGGKVKARGVIHYKNIKVGVPEIDGAGITNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K320</accession>
    <name>A0A367K320_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clock-controlled protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000357">
        <property type="protein sequence ID" value="RCH96560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K320"/>
    <dbReference type="STRING" id="86630.A0A367K320"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49874" checksum="E49643A0DCF8EB55" modified="2018-11-07" version="1">MSQQQQPQSQQQQQQQHSAMSIDQLVNTPDDMDPDVKMAVEALGDMARSKVHMTLPPLSTPSTTPSSPLPTPTSSSIQRLSFSSSTLDEPQQSRFIYRVSNIPIVNSAIRVYEHSKNSSSVVKYGAEMVESFAGPIYDKLGKPVLSNVDEWGCKQLDKLEEKYPYLSKNKETDEDEQDEDDANSTVSALARTSLLDDHETTTSGLRKRRDSKEEFTLKNTNRSRTSSRSTSPHKPYPKPNARHRPIAPRSKWHQIVLHASSAAGTTAAVISEESMKCLRYCLSWLQYASQHIEQQMNLIRKYLVSIAKSSQDKAVVVAQESPLPKIKKEIVDTLRKVVDVISKYAGTGLPEQAKAAVRSFILALPSRWAMLNSKAASPVASPALKPSDVGLHETSIKLLNFSGESLEMIQSVAHVFSDTIERAELWLSRLAVVSGSSQQAKPAVEQMDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5B3</accession>
    <name>A0A367K5B3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">METTL6_2</name>
        <name evidence="7" type="ORF">CU097_014731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000280">
        <property type="protein sequence ID" value="RCH97413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5B3"/>
    <dbReference type="STRING" id="86630.A0A367K5B3"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="96"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="288" mass="33676" checksum="60B846768FA27AFE" modified="2018-11-07" version="1">MTKEDSNKIPTKRDAERVILDKEKLEKLVNRAKEVIESDKTEVPPFWVNKYKKEAAKNWDLFYKRNTTKFFKDRHWTDREFEELQPDQSGNQKYLLEIGCGVGNFVFPALAENSSLFIYACDFSKRAIDMVKSNEQYDESRCKAFVCDLTQDLLTDQMEPNSLDLVSALFVFSAIPPEKMEFAIKNIYNVLKPGGRVLFRDYGLYDEAQVKFSKASDKRLGDNLYVRQDGTMSYFFSTEDVKSRFEAAGFSTVDCQYIYRETTNRQKEMRIDRIFTQAKFEKKNCDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5D4</accession>
    <name>A0A367K5D4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_011739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000282">
        <property type="protein sequence ID" value="RCH97380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5D4"/>
    <dbReference type="STRING" id="86630.A0A367K5D4"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51294" checksum="BC7E19E660D2EBD9" modified="2018-11-07" version="1">MAFKLPFRYSDPNVQVFLVGFICFCCPGMFNALNGMGGAGQADPKVTNDANTALAVTFTVCSLIGAPIFNILGHRVLVPAALTYVLYVGSYLTPNPGFTIATGAILGIGAGLLWTAQAGIMMSYPDEKDKGKAFSIFWMTFNLGATVGAAISLGNNFNNTTSTVSIGTYIGFMCIMGFGAFLSLALLPARKVIRSNGTPVSLHKFSNWRRETIEIFALFRDWRMICLIPLFAGSNWFYTYQFQVYNGGGFFSLPARSLNNLVYWLCQILGAGFFGWLLDFNKLGNRKSRAFFGNTVVLSTLCAAWIGAIFVQKKFTRESVALANFEKVDISSDGYAGYVILYAIFGLVDAIYQGFIYWLLGTMTNDTERAARYGGFYKTIQNAANAIAAQVDATHVPFMTQLIINFAIEGVGLLLAYIVCFQVSDVTVEEVDNLVNDQGTEIMIAGQVESVGESQKNIKVEHVDHIIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5K0</accession>
    <name>A0A367K5K0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-binding cassette, sub-C (CFTR MRP), member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ABCC9_2</name>
        <name evidence="18" type="ORF">CU097_014518</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000277">
        <property type="protein sequence ID" value="RCH97448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K5K0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="920"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="964"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1042"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1154"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="260"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="586"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="924"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1244"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH97448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1484" mass="167025" checksum="53A3B9ACCB919F7F" modified="2018-11-07" version="1" fragment="single">EGWGPFSNQRVPDFTPCFEDSVITFIPYIYVFVAGMTRIWILSKRERLPKNLTNNWLYFSTLLLILLTTTSTFIASILDKGIQWIDDVQIITQGITVIMTIFVTVLHHVEYTRNRVSSAVLLFYWLFVNIVNGVKLRTHWLNHDEDTQFILFGIYAALSVIIFVLENVPKPVGQYILLEEHDSPEEKSNIFSRLTFSWMTPLMRLGYQKPLTMDDLWNLNTEDQSAIIGARFEKDWEKEMKKPNPSLLRVLVRTLGGPFALAAFFKLLQDILQFTQPMLLKQLMRWVTSYNTADPEPSYVGIFIAVGMFLTAVCQTMFLHQYFQRCFATGMRLRAALVTAIYRKTLVLSNSSRQKSTVGEIVNHMSVDAQRLMDLCTYFHIVWSGPLQIVIALFLLYNTMGPSVGAGLAVLILAIPLNTYIARKMRTYQKTQMGNKDARVKLMNELLNGIRVIKLYAWEAPFLEKINFIRNDLELATLKKIGVLSAVQNFTWMSVPFFVSLSTFAVYVSISDVPLSSDIAFVAIALFGLLQFPLNVFPNVITSMIEASVSLYRIEKYLASPELDPHAVTRLDYRLDTTYTSSTPLVEINHGEFKWNEEDPEPVLKDINLTIKKGELTAVVGRVGAGKSSLISALLGDTIKVGGEVILRGSVAYVPQQPWVMNATLRENIVFGHRWDPEFYERVIEACSLKTDISILSAGDQTEIGERGINLSGGQKARVSLARAIYARADIYLLDDPLSAVDAHVGRHIFDHVIGPEGILKNKARVLVTHGISFLSRADQVMMLRDGQVGAIGTYNDLMSQKAELYQLITDFGKKSASSDESSEDLKTIEGHDGDIVQEETASVDLVPREEDASLTRRRRLNSEASIMSAATLRRASLASLSKKKHTAKTDNARLMTVEESAKGSVTWDVYKEYAKSCSFYGVIAVLGLLTLSQLASVGTNLWLKHWSSVNLETGNNDHVWFYLGIYALIGWSSTILSMIQTLILWVYCAIRSARVLHSNMLDTVIRSPMSFFDTTPLGRILNRFSKDQHTIDELLPRTFSGYFRVLFTVISTVLIIAFSTPAFMIMVLPLGAIYIYIQRYYLATSRELKRLDSVGKSPIYSHFQETISGVSTIRAYEQQRRFIFENENRLDDNQRAYYPSISCNRWLAVRLEFLGSIIILCASLFAVLGIVYGGSVIDAGLVGLSVSYALSVTQALNWVIRQYCEIETNIVSVERVKEYIDLPTEKYNAVRSVSPMWPEKGVIEFRDYATRYRPGLDLALRNLSFTVAAKEKIGIVGRTGAGKSSLSLSLFRIVEAAKGSIFIDGVDISSLRLFDLRSRLTIIPQDPVLFAGTVRENLDPFGAHDDAQIWQALQHSHLHEHISKLDGKLNAVVLEGGENFSVGQRQLICLARALLRRTTILILDEATAAIDVETDAIIQETIRRQFSHCTILTIAHRINTVMDSDRILVLDKGSIAEFDAPEKLIQDKQSIFYSMAKEAGLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K649</accession>
    <name>A0A367K649_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_014476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000263">
        <property type="protein sequence ID" value="RCH97609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K649"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1658" mass="187439" checksum="8BD07A1562C8C88A" modified="2018-11-07" version="1">MQPTEAGELRELLNRVCEARRIPPQAAIRLEHILQEYKPKLVKLLDDPPKNSQHRSTIESGKAIINTIEYKINKEFTKEAIFLSDHLNLDEYESSRLLLEGTRWTNKTFAPAVDTAIYLYHTERDYVMTILNTILESINDHQIDKHIRCIFLDFMVDIYLKEADSFVSKILKSLQNMNTAIKTINKDSVSQEVKLCEDTLSFRISQLNEERISLAQVLYHIASLLWLSEADVLSLIDTVRTTTLLDPTAPYLLVALLTVISPKYLEDQSRHGTSFWKSQESMKKMHDAIVGKEWKVDGVKGAVLLQWSIFNTRVRSLGISSPFKLDEQSTTSLLKKGIELDAFGFLNQYLLHFKQENGTSPDMNKVKESSDGESTMVIDGLTVDPSDYSKFYADIAPEFQSIVVHQLEYFAELFILRLSSQLHQLKTEEEDAIYQVGYSNDAHTDYVKDSAKKQNLEAFLTLLASIYRGHLNAGNRYWKREHGLFAFVKWLFDLKVVGTVRAAFDFLASIATGDECASYAYEVLSMGTSQADIGNSHLFSWGKLFATLQFYAAEIYNTLPGEECPSIPETEEQVLCSLLHLCQQVVQYSSTARIAIWEDRLLRPHESIVRMISCPTSVDLRARLYNLLAAFCSSWGGGINGIGRRISLEVWNTLEVSDLILSDKRMIAAPTVTPPSTTATETFLGSLASLNAPEPAPVANNTFSTPVTRYLLPDQSSGFLIEFDSEKNSMSYTRTLSILKLMASLIHKQSEKDALISGYSMAEPSIPPCLGSEHRSPGAAPYLSLVIDHIFLSLNNLQFTNPNNKWQLTDACLKVVENSIMSFDLEPLCDHINRLISQSSGLTVGNEDYMSILGDSSTPQSKPFQSGGAREALIAYITHPGFDVMVRILSGGSLVNELYRIICLNGNRTTEVQGPRTKRNHYFRTSLTRCLRIIHKAMSIQNAFVSVLLPQLNMCSEKLPAGELKLGNYVFPQVTTNLTSVGKTMLFNTQIITQIALLVSDESEEISILSTNILRALALQPNANPDKVQFPNYVNLPMGGIGQQLPGILSSSHEAASIILGISERLDVESMENISYDNYNYDINTIPFWRAEKTLGYDYSNEDEDILGVTHQYPSIRIAILDMLISSLHKDQPSPTLSEFLLGYDVQEIVEKGSQQKSILTSYDQDTRLSCLFSILNILRTYNSQQSNSLNQGQNSVEVHPLVAEKCYHLLHQLCSRESTSTATLHYIRANGDDLLVNQLRFIVPRIDTSLIAIEPHFAGTIKYAAGNGVQTDFFTLKSMLNQRAWLLKLLALELHVRKTTGTASLLESLYGHDTYSSLDVTNSLSDRFGSLHIQMSGDYQQPHWNLLEITSSLEFYWQDHNLGPASVDITKNYFKDFKPKDYETDDTTSHCKLFDIRGIYKYLRQTQKEMLSRGAIPEQEIIAVEEEMGNILQTLMAENRSRQIKSSRLHCLQAWKQLVEVSLLDCFDSLSRPVREKIAYDLLSTIWNKLEEESYQERVILRNMSELIVVLLTRLKADDDKSSTYLGLPNERLRQTFYGIIQFICKRVITIDIRSNLYIALVIFLQYIDLSNYSPGNLQLLETIDNETQERVLDILCNDAVDAWDTHKDAAIVAIQSLYVLFQRSKRTSIHSYLSKKNVLHLLDTSTIQANDTILIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6M7</accession>
    <name>A0A367K6M7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000245">
        <property type="protein sequence ID" value="RCH97827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6M7"/>
    <dbReference type="STRING" id="86630.A0A367K6M7"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH97827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="333" mass="38143" checksum="EDB5F36349D6BF37" modified="2018-11-07" version="1">MYQSPVPEDKYFGYSSTDIFPFSKFTDQHYHVPEKPSHQTSDSSTSSPPTAEPSPCFSDRECLEQPESEMEKSPSNFNSKRRVSLSKAERRAEHNAIERARRECLNSKFQQLADVLPNLQNHRRPSKGQIVEKALDWVKQNLTKEERYQYQIMQLQNENRRLMAHIAMNQHKPNMITPTASVSTPVTSFARNNCFDTPIKQSTSGISSAQQLYTCKTGKPYHASTEQMDMTSYSTASMDNWTQTSFSNTNERALDYIFSLQFTAPQKEERGDSKCPSDQHQGGINDSELTVDGVYHNSELYPSPWIKNQQEASYPYHLNNSSNAVYYHPPYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7M0</accession>
    <name>A0A367K7M0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000218">
        <property type="protein sequence ID" value="RCH98167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7M0"/>
    <dbReference type="OrthoDB" id="10373274at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="123" mass="14382" checksum="CB2253B2317F7EFA" modified="2018-11-07" version="1">MKKGLFEMQQEDTTLREQLESTLANTADPNRPRRTRHDELSQGPFLDNLYPDRSVQHPLGEGTKNKRQLPWGLFRKFMEDVHGSSIDNVRFNAARDHITIFRLPDLIRKVKDKHQIENGEITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8Y8</accession>
    <name>A0A367K8Y8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock 70 kDa protein 12A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HSPA12A_2</name>
        <name evidence="4" type="ORF">CU097_005312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000178">
        <property type="protein sequence ID" value="RCH98684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8Y8"/>
    <dbReference type="STRING" id="86630.A0A367K8Y8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10229">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="596"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH98684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="678" mass="76404" checksum="8150EADE3DAB4077" modified="2018-11-07" version="1">MNSGFNYADYPVIVGIDFGTTYSGCCYAFTQNEEVIDIVKWPKQNNQVYPKTPTLSLYRKGSTQLVDWGHGARRLAMKPNSSDLMLLSKFKLYLDEHLQQTDLGNGLNITDVIADYLRAFHLHVCTELLKGFAGNYDQSRFRYCLTVPAMWSDRAKATMREAAIRAGLINSNDHPDRLMLISEPEAAALYCEKKSEQFNLRHGQRFMICDAGGGTVDLIVFEIHEPPGEKRTLKEVTNGHGGSCGSGFLDLRMREYLKRKFSHYHTINDSAMELIMDTFINVIKPDFDGVEDHFLDLPASMGLGDLSDPDIGLDNGSLCLPAEELRDYVFEPVIRQVLDLIRGQLAQSPNLEAIFLVGGFGQSNYLFRRVEEEFANQVGMIGVPPRGELAVVRGAVYFGLSPQVVTERVSRRTYGVETRMLFQDDLDPPEYSVIGADGKRYCRQRFSVYVQKGQSIKVDECISKNFVISYPNDTDSDLFAFDGEGPPPRLTSHPLVRKVGHFPIRMPHLDGVKPGDKVNMTIKMYFGLTEIKIECIIRDKSFTFTSSFDAADTLTDNYPQQAQQDPYYYQQTPIMNSNQVYGVNDLTNSMSHVSLQQQPSTYSSYPPATSQPYNQSYYPPNNNYDYYAQTTYPQQQQPQQGYSSYYGGANGSQGGYSPNAAHGYPPQQQQPPGYGNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9G3</accession>
    <name>A0A367K9G3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_006669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000169">
        <property type="protein sequence ID" value="RCH98806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9G3"/>
    <dbReference type="STRING" id="86630.A0A367K9G3"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="50365" checksum="625BC2B412294B80" modified="2018-11-07" version="1">MSVTQLPTRQNVEKIIKNFHAKEGYIYLNGQTLQERDDTDVELPFRQESNFFYVTGVTEPNFHVVIDLSTNKITLVSPNLDPDAVMWMGLPDTLDQLKEKYDIDEAIYFDKLNDTLSSAPVVYTLPITKTDALDKSKVKLCDQNESKLLYSAFAEARAIKADWEIEIIRKANQISSDAHMKLMKASELGSNEAQLHALFLYESARQGAFFQAYYPIVGVGKNAATLHYNKNNAPLKDANELILVDAGCEYNCYASDITRVFPVGGKFSPEARVIYSIVLDMQKACFESCKAGVAWETIHRIAMDVACDGLLKAGILVGDKEEIMKHHVVAAFFPHGVGHMLGLDVHDVGGYPEGTERINEPGIRYLRMRRDLQAGFVVTVEPGVYFCDFLIDPVLNDPVTGKYINRDMLAKYKPVGGVRIEDNIVITQDGYINLTTVPKEIDEIEAICAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9X7</accession>
    <name>A0A367K9X7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_015200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000157">
        <property type="protein sequence ID" value="RCH98966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9X7"/>
    <dbReference type="STRING" id="86630.A0A367K9X7"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="570" mass="63739" checksum="59D1570074BA68DF" modified="2018-11-07" version="1">MAGKGVVRSIKNIAKGFSDVQIKVREATSNDPWGPSGTLMNEIAQLTFNESDFIEIMDMIDKRLNDKGKNWRHVFKALLLLDYCLHVGSENVVLYAKENIYVVKTLREFQHIDESGKDVGANVRQKAKDVTNLLMDDNRLREERRQRQGMRERMAHVGDYLNETVRQIDGGQGRYDEDADLQKAIAESKRIAEEEAKNRRQGDDDLEKAIQLSQQEALEKEKKERERLERENTQNLFGLSSFQAFPAQQNAAINNPYQQQQQQQQNPPLQLEWTTSNNAFSGLQNNPYQQTQNPYQSAFSPNTLQAQMTGFPQPTPSPAVDLFSQQPQLTGFPVTQQQQPQMTGFPATQQTTNNFLSTPSFQTSMVTGTNPFSQMNTATPLQPQQPQQQQQQSFDYSGLVFGNPQQQQQQQQQPSFSPKLNNNSNSPFNFASSPVTTNATTSAFTSSMTPTMRQANAFSSPQLGNSQTPFQSEADSKYAKLNSLLANKDDGMDTFGNQGNLRIPYGTGFANSIGLQNTGNNGTNNNANSFGSISRNPFGQAAANNNNNNKPAGQKSLLDLMQEQKQMNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KB68</accession>
    <name>A0A367KB68_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000125">
        <property type="protein sequence ID" value="RCH99416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KB68"/>
    <dbReference type="STRING" id="86630.A0A367KB68"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF2">
        <property type="entry name" value="OS02G0536400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="36001" checksum="C8C1A1E3643DB81E" modified="2018-11-07" version="1">MSHYDRERDYDSSRPRDIDKPNPCRLYVGNVSRYVREKDLRNLFSRYGRIRDLILRNFYAFVEYDDVRDAEDATKELNGYKLEGERIVVHVANVARSRLSRTRDREDRDRDGRRRDDSRERDHDYRSSRKGADSNDPDRCYNCGEFGKENDYMNVNNRLTIKHSGERAMRFQKGVCFECGETGHRARDCPRNGSHRRRRSRSRSVGKRSCSRSDSPARRSRSRSPVRRSRRSRSPRRSPSPRRRSDRSFSRSRSNSGNRAQSSSPKRRRSDSRTASPKRRRSYSSRSRRSNSRESVKEKDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCM4</accession>
    <name>A0A367KCM4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000090">
        <property type="protein sequence ID" value="RCH99928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCM4"/>
    <dbReference type="STRING" id="86630.A0A367KCM4"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25975" checksum="2F3F112572811980" modified="2018-11-07" version="1">MSQVKSDNSRYPLVPIKGSWEIPRKLFHFSIGFLVLYLYMNGIDTDQVYPKLVAFLAIVVTTELLRFNFEWFNIIYCQVCGPLMRTTEIKKVNGVVYYLLGCIIVLYFFPRDLAALSIIYLSWADPIASICGKLWGKYTIQYSGKSLAGSLGAVALGSLVTYVYFGPLSYYPQSYNTESSPVPLTIFSIYGGLVAGISEALGNSVFRFDDNLTIPVISAIMLWIPLVGLGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD81</accession>
    <name>A0A367KD81_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000080">
        <property type="protein sequence ID" value="RCI00111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD81"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="71" mass="8213" checksum="0B3B4DCDA3AD2D3A" modified="2018-11-07" version="1" fragment="single">EPLKNKKERLPDYIFSEVTEEDLESGFTVEVSWAPLPTTSHNSSRHSSDDFKGLMLTDLIDKKRSRDEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEA3</accession>
    <name>A0A367KEA3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_015336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000056">
        <property type="protein sequence ID" value="RCI00518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEA3"/>
    <dbReference type="STRING" id="86630.A0A367KEA3"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016842485" description="Small-subunit processome Utp12 domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="520"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="648"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="693"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="9">
        <location>
            <begin position="922"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI00518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114119" checksum="1B9894A6C3EC5C32" modified="2018-11-07" version="1">MVKFLVLLSTLAIAVSAEVQSSIGLFNVSSPAPNAPFVASRVLPCVYTVASNATSDNLQLSISLNSGNITTVINPSADISQGYSFQKSIGGATVYEHQFNYQIPTNTTAGSYQVIFTDNVSQTNLSIPITISAAPPTSSVQSPSASGSSSPSQSSTSSSIFKPSSAGNTLAIPKALLFMSPLLFSNLLGTVYTGANVLFTPDGNTIISVVGNRVSFFDLVNNTSYTLPIEMRKNIDHIVLSPKGNLLVTIDLDGRALLISVNRRVILHHMNFKGRTKSAKFSPDGKYFAISLEKNVEIWKAPGHTREYAPFVLIKTAVGHHDAVNSINWSPDSRFLITASKDMTARIYTVDKDLEDFVPSTLSGHRDYIINAWFSADMSNIYTVSRDGALFQWKNATYAELHEDSDTEMVEVDEDGNEIVRIDKAKWRILKKNYFNMAGVKVNVAEFFSASNLVVVGFNSGLFGLYEVPHFTAIHTLSISQHKIDTCAINSTGEWLAFGSRALGQLLVWEWQSETYVLKQQGHYYDINAVSYSSDGQYLATGGDDGKVKVWNTNSGFCFVTFSEHKSGVKAVEFAKQGQVVFSASLDGTVRAFDLVRYRNFRTFTSPNPVQFTSLAVDPSGEIVCAGTLDTFEIFVWSVQTGKLLDIMAGHTGPISSLAFSPTGMLLLSGSWDHSARTWDVFGRGKTIEPLVHQTEVLAVAFKPDGKEIAAATLDGQVTFWGVEEGNVLNTIDGRKDIMGGRKKDDRTSAENAASGKCFNSLCYTADGSSIIGSGTSKYICIYDVESTFLVKKFQISQNLSLDGTQEYLNSKYMTEFGSIEEMEEEGSDTEERVDNSLPGTRTGDLSVRKVRPEVKSTAVRFSPTGRAWAAATTDGLLIYSLDEDILFDPFDLEIDITPETVLEALSEKEYLKSICMAFRLNEKPVTHKVFEGIPPDSVSLVCQNMPEKYLFKLLTFIGVHMETSPHIEFHLLWVTSIMTYHGRYLRDHRGEFQPVFRALHKGVNRVRDDIATLCDSNNYTLRYLLTQQSLAAKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEZ2</accession>
    <name>A0A367KEZ2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_015736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000040">
        <property type="protein sequence ID" value="RCI00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEZ2"/>
    <dbReference type="STRING" id="86630.A0A367KEZ2"/>
    <dbReference type="OrthoDB" id="2383663at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="119" mass="13545" checksum="7405AB666005DDF3" modified="2018-11-07" version="1">MKIPGIQLNRLIEIFRIKGDAHTVTPLFGIKAIKNDSQSLRAAVVTGKKNVSKLAVVRARIRRRLTHALMTVSPQYPELKGYDLVIYSKLPVYNEPWPNLIKEVNLSLSKIQRKITVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF85</accession>
    <name>A0A367KF85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000039">
        <property type="protein sequence ID" value="RCI00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF85"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="3">
        <location>
            <begin position="204"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37700" checksum="BD98DAB744B521A1" modified="2018-11-07" version="1">MLLSEINSELLTCIAGHLPLKDLKTFSQVCHRFAIIAHSDAVWKEQLYNTYGVTYKLPEESWKDMYERKSEDPKNYRICPHIGYVNGQILKPYAAKYQQVLNWLPKNLNCTTCGSNCKDSGLCLYIWKGNTRNRCKDCAYSFHKAVEGHGILIRMNVLQLYCFDCNRLLGEMRGDASEAYYVNLLLEALTHDSDKGREAMRNRNRCMQERVLYTEQADRYAVLTKERYYFVDRLWMCSWFLRLCDGKLGEGPVANDSLEDPENPGKLNPHSRPRGSFKGGFSIVTPELWDYLIKTYGLKGGTYTSDDINGPEYKGLRDAIVEWRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFN2</accession>
    <name>A0A367KFN2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000030">
        <property type="protein sequence ID" value="RCI00989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFN2"/>
    <dbReference type="OrthoDB" id="2277268at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="243" mass="28383" checksum="F210C83FE252025F" modified="2018-11-07" version="1">MTICSIKDITIKPFERGQDKHIWFPVQIELDNHDKIEVYKRYSDFIRLYEQLQTIDKGTYLPLKRDNKKMYWIKRHQKYSQRQAELEKFCKYLLALPSAITNSDFYISFFNLDVSSDTSSSDSSSHGDSCTDLLRNDTILEEEEDVIRIKLVYDAHNIIILRVPRSITFNELKSKIIQKFALLNINLSPHLILLALSNHQQQTSSVSSITENVIVISSETHFVDAMQTQWLHDKKITARILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG92</accession>
    <name>A0A367KG92_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Nuclear receptor coactivator 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">PRIP-interacting protein with methyltransferase motif</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TGS1_2</name>
        <name evidence="24" type="ORF">CU097_015867</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000021">
        <property type="protein sequence ID" value="RCI01197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG92"/>
    <dbReference type="STRING" id="86630.A0A367KG92"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000066">
        <property type="entry name" value="Trimethylguanosine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI01197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="338" mass="38126" checksum="221CC9A4A0ECCB6C" modified="2018-11-07" version="1">MIILSNMKKDSKDAVIVIEQLTTSPESISGSDKGSITEPENSIEDVSTSLSEPVIESDQVQQNDDQTHNELDQQDQKENEQDLKRSTIESGHKVNNQPRSDPYAGYDERPTKKRRKQRAKKTTNDRYNGVLVSYTKGWFSVTPEKIAKHIAERCRADIIIDAFCGCGGNTIQFALTCHRVIAIDIDPVKLHCARVNARIYGVEDRIEFIQGNFFELAPFLKADVVFLSPPWGGPSYLNSSVFDLKSMIPGDGFHIFRLANDITPNIAYFVPRNTNPRQLAQLAGPGNTCEIEMNALYGKVKALTAYYGNLVNYEELEQKEQELEETHLMNRISQNFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG97</accession>
    <name>A0A367KG97_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000036">
        <property type="protein sequence ID" value="RCI00872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG97"/>
    <dbReference type="STRING" id="86630.A0A367KG97"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="63" mass="7333" checksum="0DD2EC2E6ED4168C" modified="2018-11-07" version="1">MAVDELEALAEHSISSSEARFKEVCSTFEQAVRLEIMFWEMVSIAIYLLFKSDLNKYFKMPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGH7</accession>
    <name>A0A367KGH7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000032">
        <property type="protein sequence ID" value="RCI00952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGH7"/>
    <dbReference type="STRING" id="86630.A0A367KGH7"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="112"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="25974" checksum="F6CF9C97D152858C" modified="2018-11-07" version="1">MTSAAMNGFYQHSFQQIHHQQQQQQQQQQQQQQQQSYLSAYQQSSQMLLQRYNDSFYATDTTYTTVPNTHQLTEQHKRKIDELEYKKKPKSKKKKNKIVDPNAIPKPKRKTGLNKPLILSPVLSELMDGAKELSRPELVQKLWKYIKENNLQDPADRRFILCDAKLKKIFEQDRVNSFGMNKDLSAHLTKKEEVIDQTQQSSGSVSPLDKDGIPHDDFLLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGL8</accession>
    <name>A0A367KGL8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CU097_015806</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000030">
        <property type="protein sequence ID" value="RCI00992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGL8"/>
    <dbReference type="STRING" id="86630.A0A367KGL8"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="996"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="157"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="243"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI00992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1104" mass="119516" checksum="033E00EAF7149ADE" modified="2018-11-07" version="1">MSVNTTLPIQGMTCQSCVRAITNALSPIVEKVNVDLEHACATVSYDSTQLSLEKIIKTIEDCGFDVPMETKTLSLTVQGMTCMSCVKSITLACKALQGVHSVVVSLEENKATVDYEPLETTPQKIMETIEDCGFDVAEYSKDNQHKQVKNETIGAAKMTQLHVSGMTCASCVSSIERGIGQLSGVQSVQVSLLAESATVHYDPTQLHTNQLVDAIEDLGFEATVLTEETVTPTNDENSPSDVSQLQLQIYGMTCASCVHAIETEVKKLDGVVSVSVNLMTETGIIRHNPTRVGAREIVRAIEDLGFNALVSDRTRRVQLESLSKVREIQQWRRLFFQSLIFSLPVFVIAMIFPDFAFGRDLLNTPTYIIPGLFLFDLVQLVLTIPVQFFIGKRFLVSAYQSMRHGAPTMDVLVAISTLSAFSFSLFSVIRSVLIASPVRPSVFFDTSSTLISFILLGRYLENMAKGQSSTALSKLMSLTPSVALLVEYDKDETIVAEKQIPSELIQIGDYLKVTPGAKVPTDGILVSGQSSVDESMITGEVDPVDKTSGQTVIGGTVNGLGTFVMRATRVGSDTALSQIVKLVEDAQVNKAPIQGFTDRVAGVFVPCVLLLGALTLIAWTLLVGCLGVNRMPSLLQHEIQKEGNGNWFFVCLKMCISVIIVACPCALGLATPTAVMVGTGLAAEHGVIFKGGAVLETGQKVNKVIFDKTGTLTTGKVEVVNYQAWDGAEKTRQYMLVLAALAEAQSEHLLGRAIVNKVKELRGLEPEATLDRLGSVSDFKSETGFGIECYVTLEGQDKKQHVVVGNQRWLEDFHGIAMTDDQISTVSHDAAKGFTSILVAVNGVPSGFVSVSDTVKPEAEMVIQTLHRMGIDTAMVTGDNATTAHCIAKKLGITEVHAGISPNGKTDIVKSMQSQLRPQSRFLLAPKLVPTVVAMVGDGINDSPALVAANLGIALCSGTDIAMEAADVVLMRADLTDVIVALDLSKSIFKRIKLNLLWACIYNIIGIPLAMGILIPFGIHLHPMMAGMAMAASSTSVVFSSLMLRWFWRKPSLDEQDKVKISKFRLLIRKLFQVDGRSKGVYQPLQSSQSDYDLESLAPTSPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGT2</accession>
    <name>A0A367KGT2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_014593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000010">
        <property type="protein sequence ID" value="RCI01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGT2"/>
    <dbReference type="STRING" id="86630.A0A367KGT2"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="264"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="328"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48653" checksum="68274771AC6CAAD7" modified="2018-11-07" version="1">MDHPIHRKKINDKEIKTKVKASFLRRNPDCVLALNKKAIKSRDNLSALVIGLSGLCSLLFQETFPELSAKISHCNTEFINKAASFLNARECWDIGLDANNRGVDQQLCPQDHTLFLAYLNSSSKSITSARPSTVAKWVQDEIEEAGVDTTRFKAHSLSVSLTKRSKEKSYDYFDFVSNFQESETISNLKFCRALRDAGSITTDHQHLKAIDEAKTLLKPMNYYPTIQQPFYTPTQPSLQAFNDEVIPTEPDEFILDLLKKPQERLFLLKLELEFEAFIKDKQRFRLDFPSMNSYQRLMIHKLAPYYKLNHFHDAMRKGVYVCKTFITELPAVRLLDISNGNSEPEKEQTSQGPAPQFKIMRRTTGSGSVSPRSPLSAGEEQAKNMIDRKNMTLEERKTAYEEARARIFQDLEEKQQQQVTKQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHB6</accession>
    <name>A0A367KHB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_015497</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000002">
        <property type="protein sequence ID" value="RCI01625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHB6"/>
    <dbReference type="STRING" id="86630.A0A367KHB6"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041120">
        <property type="entry name" value="RqcH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="9">
        <location>
            <begin position="504"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="10">
        <location>
            <begin position="953"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI01625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119892" checksum="4D61D487468ACF11" modified="2018-11-07" version="1">MKQRFNALDVRSTVMNLRERLIGIRLQNVYDVNAKTFLFKFAKPDDKELVLVESGTRIHTTQFSREKSDMPSPFCAKLRKCLRTRRLTNVRQLGVDRIVDFEFAGGEKSLGYHIICEFYASGNIILTDHEYRILALLRTVQPTETLKMAVGEIYNIKSVLTDFKKVDSNQLKEALSAAGPKDNLKKILNIKFEYGPAMVEHIIMESELDPNMKVASDFDTSENSPMMHALLEGFKKADDMIQSTKNAVPRGYIILMDDKKPSDDKEDAMEIYDEFHPFLYKQFTHRKFKEYPTFDMAVDEFFSSIEAQKLELKTRKQEEAALKKLEAVKQEQEKRVESLLNQQLTNTRKAELIELNLQYVDAAITIIRNAVASQMDWQDLNDLVKEEKRRGNPIALLIDTLKLDTNQITLILTDPDYHEESEDEDEEEKPKEIFKVDVDIGLTAFANARKYYEQKKSTASKHEKTIEASAKALKSAERKIRQDLKETKITATINKIRKPFWFEKFMWFISTEGYLVIAGRDMQQNEMLVKRYLSKDDVYVHADLHGAASVVVKNKPQANGQPIPPSTLYQAGIMSVCQSKAWDSKIVTSAYWVYPDQVSKSAPTGEYLTTGSFMIRGKKNFLPPVQLVYGFGYLFKLDESSIGNHVKPAKENDLSTEYDNDVLEPEQSAKVDSIEETDKSDAAEKSKEAEPNASSGISISNSEKSVNEEDGSSDDDDSDDSNSSSSSDDESAFPDTKLQSLPVSNNENVPDASKYALDEYGHDSDEYQTSSAPDSDKAQAKKRFITAKERRLMKKQNATEITEEIRLKQQKQQQKQQNNGKQKQQAPAKPSVTTPPSSTRGRKGKAKKIKEKYADQDEEERQLRMELLGSNKGPQPKGKKAKREAKAKAEKAALEKERARKEAEEKARLAQSQKEEEAENDGSLEVGEEKDSDVIRQLLKEENITMLEADEIANLSALDSLTGNPLPEDILHFAIPVCAPYPAIQKYKYKVKLTPGSLKRGKAVKQAQSVFLALSDASAREKELIKGVADMENINTMMSKVKVSAPNLETSKRKKGSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJZ2</accession>
    <name>A0A367IJZ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005489">
        <property type="protein sequence ID" value="RCH78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJZ2"/>
    <dbReference type="STRING" id="86630.A0A367IJZ2"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7240" checksum="C09FD13F92B5C1F1" modified="2018-11-07" version="1" fragment="single">MSFTLEAPLAYKILDSYFENVSYVKGVEASDADVAVFNALTEGVSAEAYPHLARWYSHIAAVKGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK96</accession>
    <name>A0A367IK96_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005416">
        <property type="protein sequence ID" value="RCH78107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK96"/>
    <dbReference type="STRING" id="86630.A0A367IK96"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="105" mass="11317" checksum="37CF140A50247AE8" modified="2018-11-07" version="1" fragment="single">AILRQAQQAQNLMQQQQMIANMGLNISSPPNNVNISNGFSPIQQSMDSPSMTSIPLQQPQQMAPTDLLAANGMINPSSILINPNNNLMLGGNNMYVGENGEDFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKR9</accession>
    <name>A0A367IKR9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01005288">
        <property type="protein sequence ID" value="RCH78277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKR9"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH78277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="71" mass="7940" checksum="2C5182AB41F57937" modified="2018-11-07" version="1" fragment="single">IQQDLHDLTLYVQINPAETPAVVKEEEEDSDDEDRIAVPEGKIDPSKFDNFKLTLVVRTDLGMTKGKIAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL53</accession>
    <name>A0A367IL53_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005205">
        <property type="protein sequence ID" value="RCH78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL53"/>
    <dbReference type="STRING" id="86630.A0A367IL53"/>
    <dbReference type="OrthoDB" id="2286212at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="16571" checksum="D873D7B1F2031B2A" modified="2018-11-07" version="1" fragment="single">QAPEGKKQATAALSSAESWPPSLQQYVQDVFANCLPGKRDEAELQLRNLILESHKAGTLLTTDWSEVDLPSACLPSKKKRKNNNNNGSISGRKKVNLQTQKMSSEEEAKKLRRLRRFEEDAAQYKAENMSSTMQQMHLDGPLVSDTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMC3</accession>
    <name>A0A367IMC3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004922">
        <property type="protein sequence ID" value="RCH78776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMC3"/>
    <dbReference type="STRING" id="86630.A0A367IMC3"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH78776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29863" checksum="4CEA013C5164CD32" modified="2018-11-07" version="1" fragment="single">MPTSRISLDDGNADDVPKDGTKHTRMYEITPELRQRIFRKCPPSGCYRDLFSNIPSQHLAYPDFAFPEGTSGLVTHQEILAYLERYATTFNLMELIDFGTSVDIAVKTVDDEWELVLSKYDVYPSGFVKETKWRERFDAVVAASGIHQEPYVPDIKDLTAFNKMWPVKVAHSKQFRRPEDFKDKNVLLIGVRVSGVDIARSLEGFAKSITMALKGNFTTPFPVENIIRAKIPKCVDVKCEVASFSNPEGIVDGSITFQDGTVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMF0</accession>
    <name>A0A367IMF0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004872">
        <property type="protein sequence ID" value="RCH78854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMF0"/>
    <dbReference type="OrthoDB" id="2441396at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="9580" checksum="544059BF7DB51BFF" modified="2018-11-07" version="1" fragment="single">MTSLIKSTAFSPMRVFFRVSTSIPSMKHAREIFRVLGEYGDMIEYRFIRCPSTFRYRQYGFVVYRNSQDAYKAVEEQFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN88</accession>
    <name>A0A367IN88_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein phosphatase PP2A regulatory subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PAB1_3</name>
        <name evidence="12" type="ORF">CU097_000972</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004685">
        <property type="protein sequence ID" value="RCH79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN88"/>
    <dbReference type="STRING" id="86630.A0A367IN88"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000441">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000590">
        <property type="entry name" value="Polyadenylate-binding protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="182"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="334" mass="37672" checksum="4ECB8D01DA04599C" modified="2018-11-07" version="1" fragment="single">ALHDTFSAFGNILSCKIALDENGNSKGYGFVHYETEEAADNAIKHVNGMLLNDKKVYVGRHIPKKERQAKIEQIRANFTNIYVKNLDESVTDEELRNMFGKFGAITSALIQVDEEGKSKGFGFVNFEKHEDAQKAVDALNETEHNGKTLYVARAQKKNEREEELRRQYEQAKLEKLAKYQGVNLYIKNLDDDIDDERLRQEFSVYGVITSAKVMCDEKGTSKGFGFVCFSSPDEATKAVTEMNGRMIGSKPIYVALAQRKEVRRSQLEAQMAQRNQMRMQQGIPMPGAPGYMPSAPMFYGPPGGFMPQGQRPVFPPNGMMPRPRWAPQQGQPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPP7</accession>
    <name>A0A367IPP7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004357">
        <property type="protein sequence ID" value="RCH79674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPP7"/>
    <dbReference type="STRING" id="86630.A0A367IPP7"/>
    <dbReference type="OrthoDB" id="2278877at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="18952" checksum="1C8E55E3AC60A2C0" modified="2018-11-07" version="1" fragment="single">DRLTLDQMMFSRNLSPLQSSKFSFEYLLLPPRSALEAVSPRFTPRASQQFIKTSTPAYSLLLRFYNNGRVWSFAPIPKFDDRFARQNRYEPPPEFPLASPYSGIVHHLSGPIISALSRSIQYKTSAPDDTASLRIRINQFPYAYGFGTQTLALMVDSLVRVSRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR46</accession>
    <name>A0A367IR46_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disheveled-associated activator of morphoproteinsis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DAAM1</name>
        <name evidence="3" type="ORF">CU097_001264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004072">
        <property type="protein sequence ID" value="RCH80148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR46"/>
    <dbReference type="STRING" id="86630.A0A367IR46"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="467" mass="53726" checksum="3CFC4DD627552EA4" modified="2018-11-07" version="1" fragment="single">IHRRQLGNTIWEHLEDDDQDDVIDSNDDPADEPLFNQQSIVSKLSHADVFTLIEKTFAQKPAVSDLTKRKRKAADSIELLDPKKAHAMSIFLTSLPKEFEIKRLTEYVLDISPYIQVELVLENFLKFAPSSEEAEALKKYKESGESIERLSKPDQLVLEMVNISQFKPRISCLLYKTVFWDKVEGVEKALDLILKASESLLHAKRFKKLLQMILVLGNFMNGNTSRGGAFGIKITSINKLIDTKSTSNTSSTLLHFIVETIEKSFPKVLEFLDELKYCEEASKVNKTEVMTDFYEIKDGLKQFDVLSGDDSFTEIMKHFQTEAESKVSQVEQLQVKSDELFQKTVSFYGENVQTVQSNEFFKIFHTFITSWQKCTEDLKLAKKTKERLEAQKRIEAERRNQAKSSKGKGIDMSDYTINTQHDIGIEALYAKLLMSPRREHKTRQRQQKLNPIISNELNALELLESIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISJ6</accession>
    <name>A0A367ISJ6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1, regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPP1R3C_1</name>
        <name evidence="3" type="ORF">CU097_003798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003796">
        <property type="protein sequence ID" value="RCH80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISJ6"/>
    <dbReference type="STRING" id="86630.A0A367ISJ6"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="167"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="42267" checksum="D13B51289CFE0464" modified="2018-11-07" version="1" fragment="single">MSNTLTMHNYANKKRVTLNKKSLLLDYRQPEQERQVEANDYTRQLVTSALHLPSSTDVNIIQSSPINTSDKTVIDLPRILKSSIRAPKSAPCSPTKSVQFDKENLENICYFRKAQTPSTISHRKNIFWADSDDDEEEDEEEDEEEKKEEATLVFPNWSNGRLADIIDKRNKVIRIEKGFFTVKDNILHGKVLVRNLDYQKSVTVRYTFDYWETVQNVHAIYQSNYHSNTLYDVFTFKINIQSSSLYFAIHYKVGTQEFWDNNDCKNYEIQFVHNRPASTSMNKDQQEENQLKKRYDFSQAISKQQQPITIKPTPSIPIDSNSNSPLYCHSPLASSPSFMDLNSQSYLDLVNKYCFYSSSPTRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITR6</accession>
    <name>A0A367ITR6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TUBA3D</name>
        <name evidence="11" type="ORF">CU097_004617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003602">
        <property type="protein sequence ID" value="RCH81052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITR6"/>
    <dbReference type="STRING" id="86630.A0A367ITR6"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000022">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000019">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH81052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="308" mass="34287" checksum="627CE5B1581709FC" modified="2018-11-07" version="1" fragment="single">MREVISIHVGQAGVQIGNACWELYCLEHGIQPDGHIPQNLQADDNSFDTFFSETSSGKHVPRTVMVDLEPTVVDEVRTGAYRQLFHPEQLITGKEDAANNYARGHYTVGKELVDSVLDRIRKLADNCTGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFSVYPAPQVATSVVEPYNSILTTHTTLEHSDVSFMVDNEAIYDICRRNLDIERPSYLNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVTYAPIISAAKAHHEQMSVQEITNACFEPNNQMVKCDPRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUL3</accession>
    <name>A0A367IUL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_003250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003454">
        <property type="protein sequence ID" value="RCH81395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUL3"/>
    <dbReference type="STRING" id="86630.A0A367IUL3"/>
    <dbReference type="OrthoDB" id="2384071at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH81395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11438" checksum="8F273D0E75669787" modified="2018-11-07" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRNVLKSFLENVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW75</accession>
    <name>A0A367IW75_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine desulfurase, mitosomal</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NFS1</name>
        <name evidence="16" type="ORF">CU097_004822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters in mitosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01003243">
        <property type="protein sequence ID" value="RCH81876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW75"/>
    <dbReference type="STRING" id="86630.A0A367IW75"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032047">
        <property type="term" value="C:mitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002806">
        <property type="entry name" value="PRK02948.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1025">Mitosome</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="15">
        <location>
            <begin position="64"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00084113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH81876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="434" mass="48095" checksum="B25A693FC94E8FE4" modified="2018-11-07" version="1" fragment="single">MLGRTLRQSVLRASFYTARKTAIPATYRLFSTGLTTKQEAEAIKPTEDSLGFEQTAVKNEGRPIYLDMQATSPMDPRVLDAMLPYMTELYGNPHSRTHKYGWETEEAVEKAREYVAKLINADPKEIIFTSGATESNNISIKGVARFYKNKKKHIITTQTEHKCILESCRSLQQEGFDVTYLPVQSNGLVDLKKLEEAIRPDTALVSIMTVNNEIGVIQPVEEIGKLCRAKKVFFHTDAAQAAGKVPLDVNSMNIDLMSISGHKLYGPKGVGALYVRRRPRVRLEAVQSGGGQERGIRSGTLPHPLVVGLGEACKIAVEEMEYDHQRISNLSKRLIDGITSKIEHVYRNGDPVHSYPGCINLSFAYVEGESLIMALKDIALSSGSACTSASLEPSYVLRALGADDEMAHSSIRFGIGRFTTDEEIEFVIKKVNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXS7</accession>
    <name>A0A367IXS7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS19_1</name>
        <name evidence="4" type="synonym">RPS19_2</name>
        <name evidence="6" type="synonym">RPS19_3</name>
        <name evidence="5" type="ORF">CU097_003069</name>
        <name evidence="4" type="ORF">CU097_003824</name>
        <name evidence="6" type="ORF">CU097_007445</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003533">
        <property type="protein sequence ID" value="RCH81211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01003006">
        <property type="protein sequence ID" value="RCH82462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01001176">
        <property type="protein sequence ID" value="RCH90101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXS7"/>
    <dbReference type="STRING" id="86630.A0A367IXS7"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH82462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16130" checksum="A9C299CDF9ADE99E" modified="2018-11-07" version="1">MAGITVKDVNAHAFIKAYAAYLKRTGKLEVPKWVDLVKTGTFKELAPYDPDWYYIRAASVARHIYIRKNVGVGALNKVHGGTVNRGSRPSHHVDASGSVNRKVLQSLEKIGVLEKDKKGGRRITQDGQRDLDRIAMTLAEESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXT2</accession>
    <name>A0A367IXT2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002996">
        <property type="protein sequence ID" value="RCH82487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXT2"/>
    <dbReference type="OrthoDB" id="10271205at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="281" mass="32287" checksum="152BEFB7B0B7CEE8" modified="2018-11-07" version="1" fragment="single">MFDTQSNKLKLKTGSVTFPDSINKFLNPFDIYNEFSEALIWDDRITYDHKEVIETKVFKSVGERFVHSILTDTNIKHWLLLTEVDIFLPNKKNIDSCSYDLESTELSKFTIKISKDKNQGRRYSELTVQAGCFQILATGGIYRNQDTLLGGFLGSSIPSNSTHEYNTCYTLRQPKESRCFYRLLRDYSKPDASYFAGFRSAIFTDHGFQGAHPLRYYQDEKPGVANLSVIASKIICNYINKRAGKNDIIEYLRLFLKTKVVKEISNERLKTVATVADMGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXY7</accession>
    <name>A0A367IXY7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_000216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01003045">
        <property type="protein sequence ID" value="RCH82351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXY7"/>
    <dbReference type="STRING" id="86630.A0A367IXY7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH82351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="153" mass="16690" checksum="CB04E6C975321B60" modified="2018-11-07" version="1" fragment="single">MGAKVSIPHSVLHSARKRSSRTISKHASPTEYEQTLTDHSGDSRVSSTTVDLSLLCFNAHQKTASDRMTCNHFALKALFEGNVMPVIKQHIDFSSTSTAVLDIGCGSGSWVMDMATEYPSTQFIGIDQLPLFPHDIRPANVTFKQADVLTGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYH2</accession>
    <name>A0A367IYH2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002921">
        <property type="protein sequence ID" value="RCH82712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYH2"/>
    <dbReference type="OrthoDB" id="2287509at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10228" checksum="2F66CB9FD7FA0B0A" modified="2018-11-07" version="1" fragment="single">LRFFEVKQRKNAKAPNTSKEIFDIGILLEIIRLLTIATMWRPCSDMGNLQFRDMASIIDHEMHTSTGVPLIARQPKEITAKTSKLVATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ50</accession>
    <name>A0A367IZ50_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PCYT2_3</name>
        <name evidence="13" type="ORF">CU097_006652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01002831">
        <property type="protein sequence ID" value="RCH82956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ50"/>
    <dbReference type="STRING" id="86630.A0A367IZ50"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="191"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH82956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="329" mass="37049" checksum="965F00F9890B604A" modified="2018-11-07" version="1">MTERKPVRVWVDGCFDMMHYGHANALRQAKEMGDILVVGVHSDAEIEKNKGPTVMKEQERYAAVAACKWVDEVVPNAPYNTTVEILQKYNIDFCVHGDDITTMADGTDCYQAVKDAGLYKECKRTQGVSTTELVGRMLLMTRNHHRDVDPKEVEPFSAPKSKVSHFLPTSKRIVQFSNKGVEPKPTDRVVYVDGTFDLFHIGHIEFLKRAKEQGDFLVVGIHDDQTVNAIKGINYPLMNLHERALSVLACRYVDEVIIGAPYSVTEDVLDTEYNVAVVVHGTTSSEPDIDGRDPYELPKSRGIYKEISSPNSTLTTQDIIDRIIENRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ61</accession>
    <name>A0A367IZ61_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CCT1_2</name>
        <name evidence="12" type="ORF">CU097_007319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the T-complex protein 1 (TCP1) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002827">
        <property type="protein sequence ID" value="RCH82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ61"/>
    <dbReference type="STRING" id="86630.A0A367IZ61"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="183" mass="19620" checksum="B0F263BC9778485C" modified="2018-11-07" version="1" fragment="single">MFQRDQNNSLFLGGERTTGQDVRSSNVLAVSSIANIVKSSLGPVGLDKMLVDEIGDVTITNDGATILQLLEVEHPAGKVLVELAQQQDREVGDGTTSVVIIAAELLKRANELVKNKIHPTTIITGYRLASKEACRFIANEMSTKVDTLGKECLVNAAKTSMSSKIIGSDDEFFANLAVEAMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZX6</accession>
    <name>A0A367IZX6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATG7_1</name>
        <name evidence="10" type="ORF">CU097_000682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002735">
        <property type="protein sequence ID" value="RCH83220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZX6"/>
    <dbReference type="STRING" id="86630.A0A367IZX6"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="258"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH83220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="578" mass="65142" checksum="ECF4B34723FEB554" modified="2018-11-07" version="1" fragment="single">TDQQGQTVLMPSHFFIPSHGLDNTQDKDGIKGTLINTNTVEAFRTIDKNQLFQEATLKIKEAVESGEALKDPKKLYHYLLLTFADLKKYKFYYWFAFPAIIPDQDGWQLDHQQDLTSEQASVLHAAYQGQYYFLIKKETERMQILSLDAFEKNDQTIWFAFLDPSPVKGSPGWPLRNLLYLIYTVWGLKKVRILCYRQSDPYLIDASLPEHCSYQTTKSVGWERNVQGKLGPRMADLGPLMDPARLADTAIDLNLKLMRWRLMPELDLDKIKQTKCLLLGAGTLGCYVARCLMGWGVRHITFVDSGTVSYSNPVRQPLYRFQDKGKPKAQTAAEQLLEIQPTLVAKGYDLTIPMPGHTHNHLDQDLTTLTELIKEHDVIFLLTDSRESRWLPTLIGTKLNKWIINSALGFDSYLVMRHGTRQNQMGCYFCNDIVAPTDSLTDRTLDQQCTVTRPGLAAIAGALAVELMVSLLQDPKGIHAEASTNASDSSAGSILGLLPHQIRGFLGQFNNLLIVGQSYDKCTACSDKVLEAYSQDPLSFVQKVLDDPIYLEDITGLSALKAESENVLDDWTAEEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0Z1</accession>
    <name>A0A367J0Z1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002608">
        <property type="protein sequence ID" value="RCH83608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0Z1"/>
    <dbReference type="STRING" id="86630.A0A367J0Z1"/>
    <dbReference type="OrthoDB" id="2290810at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="456" mass="51802" checksum="DF53927F83851577" modified="2018-11-07" version="1">MSFLKGRIQLSDNQTTDIRTRNTWLGYLALPCCTYLNLKRIQLPDDSDDEQLVDEQDLEYESQPYMPSHIPTFQTQNSQQILSKNPFARAEEPPEEDGKSIQAELEDSGQTNVQAEGSEELVEFNGTSFATRNYENEPDWTELYHDDDDSDKENESKGKEEQVDTLDDTQKVTEEVDVFDKKQNEKIPQIEKEVLHLLPLPELSEEIPPNMIHKSLSLEKSLYGEEPLTSGSRSSHRQSLSLNRFSQLSFSSYIQSTEDSPEPRQQDRLMDPLSVQIEQIDKTEPILPASNSLVDDKAENTTVDEEVSEDPLIKSNSVINKESNSESNQSGIDFLRRGSSSFIEAAAPAIARFMTHVTGDEQSFAPMSLLSVLAESPPSAEDVIEEEEELFDFSKVVEIGKNMKGFSEELVESSIRMLNDVATRVKTTVEQQQDDDVVNQEEEEEDHDNDWMHTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J305</accession>
    <name>A0A367J305_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein mss51, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MSS51_1</name>
        <name evidence="3" type="ORF">CU097_002687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002458">
        <property type="protein sequence ID" value="RCH84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J305"/>
    <dbReference type="STRING" id="86630.A0A367J305"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="244"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="440" mass="50920" checksum="A4410B11A70AB92F" modified="2018-11-07" version="1">MNRTLITASRRLLLRSVVRQSPVSRHVITRSLTQTAVRPIFKGIFRNTSAQDTDNKRQVILDQDHLFHILSKSPIAEMRDRAAIINKYGTCPVCDNQEAPKQKPTYDCPECGYPTHCCEDHYHQGKEAHKEVCSILREINEDDHDLRSGRPMREFEFPSAQGFDETVNMANWDMFFYTRSFPSMDSDRSMRHVSKLLTYPISIAAVLHESSPYKYGDQITAEGMRSIAALRTILYPKNQLVNDAQAQVRTETINIYLLGARAEATLPSHIWLQLAYLFPSTPFHIHFIGPDALAPNQEPHMKSVNERLFFTFDNAMYHDYHEKIEKFDPYTDFFFLFSPGIGHHSAREGWKPSIQKALETKCAMFITGYDEADMMNDVAAVEQDYQGEFDWVLKPTVNEYRSLKRDVNLMDLRQTIFANYGIWGIRGKRYDVTHNPEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4N2</accession>
    <name>A0A367J4N2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002241">
        <property type="protein sequence ID" value="RCH84883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4N2"/>
    <dbReference type="OrthoDB" id="10626076at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="115" mass="13003" checksum="E820774E572190CA" modified="2018-11-07" version="1" fragment="single">NTTRLPLKFNKSFKTTSLFKISLPFWVWMNCLKKISSLSNVLVRFNVSCLNLSLLPKSSPVTKVVLSSSKIPFAPSRKSWLVSTITCLKTLSTCKVISMMFKSVLKNSPRNWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J644</accession>
    <name>A0A367J644_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEN-1_2</name>
        <name evidence="9" type="ORF">CU097_005164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002102">
        <property type="protein sequence ID" value="RCH85424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J644"/>
    <dbReference type="STRING" id="86630.A0A367J644"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="7">
        <location>
            <begin position="298"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH85424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="605" mass="67820" checksum="2549E3E05B3F2B00" modified="2018-11-07" version="1">MLSATRLVRTLHRRRSPFIRLYRSFHSHTDPRVEKAVYVTNERGSNVIHDPLLSKGTAFTLDERERLAIRGLLPPRHQEMEKQLLRVKRNLDACPTPLSKYIYLAALHDRNETLYYKLLMKHMNELASIVYTPTVGEASQVSHAIYRRPRGMYFSTQDRGQMSAMVYNWPQDEVDVIVVTDGSRILGLGDLGANGMQIPIGKLSLYVAAGGIRPRAVLPVVLDVGTNNKELLNDPLYLGMPHPRLTGNEYYEFVDEWVTAVKSRWPDVLIQFEDFQNPHAYNLLNRYRDSITCTNDDIQSTSAVTLAGILASLKARGKTPDNLTDEKIVCVGAGTSGVGVCEGIVDCMVDQGRVKSREEAYSKIYMLDSSGLLGNPSISSDNRTAQKRDQSISEQQRPYVKRDLPDQLSLEEVVRQVKPTVLLGFTGTRGVFTEKVIREMASYNERPVIFPLSNPDSHSECTAEEAFKWTDGRVIFASGTQFDEVRLPNGRVGKTNQCNNSYTFPGVGLGVVVSKATKVTDRMFLEAGRTLAEMASESQLKQGQLFPHVDHLREVSFKIGTRVCEVAFEDGVANATLKEGELLSELVKNTAYEPQYVPLVYHPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6P8</accession>
    <name>A0A367J6P8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002081">
        <property type="protein sequence ID" value="RCH85509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6P8"/>
    <dbReference type="OrthoDB" id="2441347at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="139" mass="15958" checksum="3474ACF4C69AA7C7" modified="2018-11-07" version="1">MEQHNTTSLVQPLDVGIIRSFEHHYKTLQFRLPGVAYAKDKNKDASDSVALNASDVYSINQLTVINYILQSWERQTLEAEMKRLLSDIYTEINADETDLLNYDAQTHEDTEVSLKEAVGEDRAGEEIPDNEEEEREAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J788</accession>
    <name>A0A367J788_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-histone chromosomal protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NHP6_2</name>
        <name evidence="8" type="synonym">NHP6_3</name>
        <name evidence="7" type="ORF">CU097_006067</name>
        <name evidence="8" type="ORF">CU097_006535</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002012">
        <property type="protein sequence ID" value="RCH85798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000853">
        <property type="protein sequence ID" value="RCH92263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J788"/>
    <dbReference type="STRING" id="86630.A0A367J788"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="10994" checksum="4E7EC7D5C1EB69B3" modified="2018-11-07" version="1">MPKEAPTKVSKRASPDDKKKRGKKDPNAPKRALSAYMFFSQANREKVIKENPGAKFGEIGKILGARWKELSDEEKKPFVEQAEADKKRYEEEKAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8W2</accession>
    <name>A0A367J8W2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DEF1_2</name>
        <name evidence="17" type="ORF">CU097_005523</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001875">
        <property type="protein sequence ID" value="RCH86404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8W2"/>
    <dbReference type="STRING" id="86630.A0A367J8W2"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="16">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="449"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="696"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH86404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="811" mass="88918" checksum="532BE3BB3053B037" modified="2018-11-07" version="1">MTSYETRSSQNTRNKSSSSEQNDLKKLKSKYSAKLPTLKVLFSDWSDDDLLFVLEEANGDLDLAIDRISEGHANQWGEVKTKKSKKEAQKAKAATTASISPHQQSSTMTSYSPKPSTPSRSSNNDRPNRAGKASAPPNRARKINTSSNASSSWDKHHDSSAPAAGSWASIASSKQQNENVDESWNTTNATDNWASTSTQDNSANNNNDTSNEDQPKTWASLLKSKPKPEPETPHVDTEQDTQTTTITDGWNTTSTNVNDSWNTTGAAANDGWNATSNTTNDGWNTATTTTEHPVVDEWSTPVDTNESTTKDTSKELESSHKEPEVNKEEDKSTLNRLHNQEEPVVLPKTSDIASLDVKFGSLNVDDDQPEILKKETNSTAATTNEPAAESKPTTASAVASNTIPSTTSGAAANAATAHDANFAQSSYLKQQEATITTSATSAPMNTTTSAAAATAPAYQQQQQQQQQQVPQQQQLPQQLPHQAVPQQQQQQQPFGMDHLTSAYSSYLPSQPPTGVSGFGMNPMGSLPDYGIYGTEAQRAAAAMGYYDPTAFSHHSPSVTSASPYQARDKYSQDTTGQAGAQSQTLPQQMYPTNLPYYQYYYMHNQYNAYQQSAYGQPFMNKSMYPNMYQHTTAAGKPTTAAAAAAATVQSPYNSPYGQQSQLYNQAMSGYDDLGLSDYQKSMYVQPQLQGFLGHLNHHQQQQPSAQGAQQTQPTQKADMTSAARTAASNAASQQQQTPASQQQQTQLPQQQQQQQLHQQHPYAGTNNFFGQPQMFSYQQYPQYQQHMTQGHPQQQTQSTVTNRQQQQYWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAJ4</accession>
    <name>A0A367JAJ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide exchange factor lte1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_003744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001762">
        <property type="protein sequence ID" value="RCH86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAJ4"/>
    <dbReference type="STRING" id="86630.A0A367JAJ4"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="162"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="595"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="103903" checksum="B21E4BF0F3136833" modified="2018-11-07" version="1">MSTRKRANSIIPVELIKDTADGGMERAALATVFGVKEYTESKIFWSSDSITSVSFKPFESLCSLPTIPKVSEFGDIWIETDKTHSHLQHEQQCHDRGIPPLDLSDYPLILFDIVKSDNSPCIIWRNTSNQSHQHETVARKKHIWSTELFSRKQEPVVTDVPQQREIEAATIEKLIEKMTVSLDYAFMTDFFLIYRIFMTPIQLAKFLISRFMWGLENDDEERCVTRVRTFVTIRHWLLNYYLHDFVPNKELRIILTKFLNEISLHPVIKQSPRDKRIIKTLKRVVRRLKRLYYTSSTDVQVIEPPPPTFEQARVTEMVKDKLSKNTIRQRIHGIYVDRRHRANTAIRDKQTAPVVVIGSTHYNSTATPLYQTSTHSRSASSLPIDESNYMNRRGDDRNEHDSDDSIGSYLTPGTSGIEDEEEDEDDDEEEEQEEQQEQAEEDAALQADLSLQEQQKLENARMHRPFYNAQLAIPSISSPSNDNLTPIADGPAKDYFDPELNASKRQKEKKKDSLYSNRINKPLPPISTGPSPAASVRSYFSHKVDNQSKEQWKFAIKNKHSDKSLRSRITEMDIPPNSTSSRSNNNYQSILLSYPTSVIAQQFCLIERNVLLGISWEELVDVRWTKMPAGLHLPSEFYNDDDSDVSGEQFNQPGIYSRKRRMKQQQEREKDYSERGVEKAIHRFNAVCQWVSSEIVQTVPIETRKCKLYCNFSTLIQILLGLQSSSVLRLEKTWSMVSKREMKVLKELSTFTSPTKNWKNLRDSMTQVAEEYGETPTEIQVENMGKNAITVKLPFGGCIPFLGIYLSDLVFNAELPSYIPSSYNPSAFQSQLEVTVLSQPLIHFRKHRITASIIKKVLIFQALAKRYSFEENLNDKLYLACLQVPCLETDEIQKRSYQIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB23</accession>
    <name>A0A367JB23_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligosaccharyl transferase subunit ost3/OST6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OST3_2</name>
        <name evidence="11" type="ORF">CU097_007650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001723">
        <property type="protein sequence ID" value="RCH87120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB23"/>
    <dbReference type="STRING" id="86630.A0A367JB23"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016859749" evidence="10">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="36081" checksum="4E33C7A98D1E6A77" modified="2018-11-07" version="1">MKRVIPLFCALVIYISLTLAQADPKKDKLTSLINQEGIIKLNSNTYDRFTEGKRNYSMVVLLTALSPQFNCHPCREFDPEFSLVAKSIQSSKHNKDLFFGHLDFADGQAIYQKLQLVSAPNVFYFPPQKAGESKEFIKYDLTRNGFAAEAFADFLSQQTGFKVKVKRPFNYVKFGGQLFLAIGAAAILKLIYRNFGFIVYHKTTWTAVSILTVLIMTSGYMWNRIRAPAYVIPTQSGQINYIAQGFSSQLGIESQIVASIYGSLGLSVLALIKMVPHFEEKSRQRFAVFLWIGCFVFIFSILLALFKIKNGGYPFKLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCY6</accession>
    <name>A0A367JCY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001628">
        <property type="protein sequence ID" value="RCH87581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCY6"/>
    <dbReference type="STRING" id="86630.A0A367JCY6"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="23244" checksum="C170B6A9E654783B" modified="2018-11-07" version="1" fragment="single">WITGPIEDDNKRISAYQDIFKALIRAAASKSRECAVQLNGCKGVMLWSDSESELLSIGHVLGKRTLWGWLGGMATLRATMVHHRQLVKMKKQVMQGRPHLTIYFIGVLPAERGRHVGRHLLEYVIKKADEAQLPIFAEVSEDKTVQWLRNFSFETKASKSLSGKEGITVSYVVREPKLDPTTPTPLTPAIASLSLQPPREDAVANNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD01</accession>
    <name>A0A367JD01_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001599">
        <property type="protein sequence ID" value="RCH87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD01"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18578" checksum="249271707D157CF4" modified="2018-11-07" version="1">MVKLGLYIKADLENVTDLAPFEDKEWYFKIECTSCHEVDDSWISFNRQDTYDMSGSRGSANLVMRCKFCKREGTAQFEPSFKIKNYSIEQNGKFQQIAQFDCRGLELVDFQARDSWSAKGAETETTFNDIDLSEGEWADYDEKAGEPVGISNIEVEFRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE47</accession>
    <name>A0A367JE47_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_005875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="PJQL01001512">
        <property type="protein sequence ID" value="RCH88200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE47"/>
    <dbReference type="STRING" id="86630.A0A367JE47"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="164"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="415"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="536" mass="61618" checksum="2C40F6F10D75B8B3" modified="2018-11-07" version="1">MLLSTDSNLSGVSILASTTDEQNKILSPEALQFISTLHREFNSTRKFLLQRRVMRQKEIDQGKLPDFLPETEHVRNDLSWRAASPGPGLEDRRIEITGPVDRKMIINALNSDAKTFMADFEDSNSPTWENCINGQINLYDAVRRTIAFTNPAGKKYKLKDRTAVLLVRPRGWHMEEKHVLVDGEPISASIFDFGLFFFHNAKEQIKRGYGPYFYLPKMESHLEARLWNDIFNMAQDMLSIPRGTIRATVLIETILAAFEMEEIIYELREHSSGLNCGRWDYIFSFIKTFRHHPEFVLPDRFEVSMTVPFMNAYVRLLIQTCHRRGVHAMGGMAAQIPIKDDPKAHEIAMQKVRTDKLREVKAGHDGTWVAHPGLIPIALEVFNEHMPGPHQIDIHRQPERITQKDLLNVSFEGRITEKGLRDNIQVGLDYMESWLRGVGCVPIHHLMEDAATAEISRSQLWQWARHKCKTAEGHQITGEYCLKILDEEVQAIRQRLGPKYSSTKYELAKMAFATNITGDQYDDFLTTLLYDHILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE70</accession>
    <name>A0A367JE70_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPAP1</name>
        <name evidence="9" type="ORF">CU097_002664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001504">
        <property type="protein sequence ID" value="RCH88243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE70"/>
    <dbReference type="STRING" id="86630.A0A367JE70"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="305"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1137" mass="129435" checksum="54BE37A55F6810B5" modified="2018-11-07" version="1">MSTFTRPTFNADDDDDLERLQQEFFANQQKPAAKVIRKGDSSQQQNKRSVFAERLAKEKDTGMPTLEDVEYEPVMDPHPEPHVPVSKKMIDLTSMLGQVLGDITEHTVDKVTPPSLPEEMPNKPARGQKDGFPKPVHRSEFKRRLEAKRNNTKPPRPEAPPQVAASTPVKASSEPLLGSSMYTDENDRRIQEMSEQELEEARAEIMNTLSPESVAILMKGLKKKHTEPVENKKKVTFQEPESSKDEGQELLEMKSKYFSDVPVENEKLAWIDDRFLTNELKEQLQKEKEEDKSQASEIEKVYRKVRFDLQGNIINDNENIPVHKGLHHHGDEPEKAGYTLAELFYLMRSQVPSQRAIVLSTVSRIITKAKHQQSDETWWKILRVFTGKEHAAPIYLRSALDDRHLIALVGAVKALAALVLDLEDDWEETLIAKAVDFNRFLGHIAHPVLPSGSKALERKGLNDKLSELVDRVRQQSGVADEDEKEDDAALAEQDLARALIKMNILPRIRYLIASENKSELIQGDPASVELLVRILVQLAEAGEDICDSIEEEELIEPVVQWGIVKTQWPMTDDGNVFVYPSLAAVRLLTVLAQGSKHIAEEIVERMTSLLPFLVTNPDIACDSLKRRAYALQLETLKLLRVLASYGFIAPILESSQEPVMDWFRVVLDKKQRDTRLQVIRASAAIELLEVLLHAAADPHKTIPEHAIDWPQPTAYLPAITAILKYTQPGPLYESALGYMGAWATYIDLFKPELETVQQSWKTITQEEDAFIFSNSAASGGYTTHHIYRYIQFISAYASLHDHSLYGDLIKEAKERIVSAWDIVKNNSRKDMYGRYALWLWLKQCKKEDMQLSMAELESGIQSLHTGITETWMAQDFLQLCLSTQVVDESMRPFYFQIQTKDLEISKALFRYDGRPVKTLMYPQIEENKCEDSTLEASAFIMSPIDAMYHLDKSKVAQKSKDDAATVVSKTFEIAARLFQEEVHHELAIVTLMKVFLIGDREGREAGVESEREIFWDDRVSKKISDLLDIHCRIKTSLSALENAWRRSSGYIRQAQVPFFQFYQSFIAQYASVSFGHHGFARLLVYLVTQIDVIDYRHLLFSDYHDILSTLKVGVNEVPQLSSVEIEQLSKAGLVLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF71</accession>
    <name>A0A367JF71_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001439">
        <property type="protein sequence ID" value="RCH88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF71"/>
    <dbReference type="STRING" id="86630.A0A367JF71"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="206" mass="21187" checksum="7EC3AA619B92C87E" modified="2018-11-07" version="1">MAYGEADSYQGGQDFYPKPDVSQVSRLAKQHAQYDDDDDDENGVFSQALHNVIGRDDAKKELDEDTANHAANAHNQIYNENNGQPSQEHSSRDLGSAAAMQAFKMFSGGGSGGGSGELIAMAMGEAQKLFKSQGQGGGGANQAEMLQTAAMVAMQLFMTQQKSSSGGGGGNLGAVMGVLQSLGGGGKKQESGGVSGTISNVLGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFM1</accession>
    <name>A0A367JFM1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_004074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001413">
        <property type="protein sequence ID" value="RCH88753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFM1"/>
    <dbReference type="STRING" id="86630.A0A367JFM1"/>
    <dbReference type="OrthoDB" id="2281547at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="89"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="614" mass="70361" checksum="E651132BBA41228F" modified="2018-11-07" version="1" fragment="single">LHALGPVNLDKTRQEFSQHINSIRNICSQFETEVLGDVMKMGAGADPAFRKHFTHLKEQATLESTVIRLKNILIKSKERLEESLKEKDESKSKIEIQRLEKIAQSMGLITFVDSSKMFETENPITTITLGGTLIVIDIDIDDVGRIHNTKVTFVSESMQAEEGDRVDRILKENLQSCNFELFKRNLQSLALLDQLNVKHKPMDFFSIINNLLKDLKTICSNELQVEPDLLTILLEGHGIPCLHLNYPGISICYWVDKSHNDIDWEQVKEQYIQRDEYHLILSQSSKLLISFEDCIQEMHYLPTTRSNYLLEFDETEEDIDSEQFKVVYENNYPKFMSPLRFVKPLSSTPSVQIRFIATLDPPIPMSDGLCQKIMNLSGMINTDSVISDHVVASTTSTSVTSETLSLEEMLVPDIVPTKQYIHDKQIYKWMSSSKVSAKIVTRIPFQHPVQLYSIIQCLRQQEMFNILFKSIFNTTQIIKNSMDNTVSFSLKGILAESEKEDNLIVEVATVDAPYSIHITLSPPSASSFIMVSLSIDIPANDPTKPIVRLQSSPIHKWNTNVFKQDLMSKELQSTYNLPAFIRWLSNRMGQDSFIKRERQEDDMSLVFKKAIKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFM8</accession>
    <name>A0A367JFM8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HBS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HBS1L_2</name>
        <name evidence="6" type="ORF">CU097_007242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001422">
        <property type="protein sequence ID" value="RCH88696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFM8"/>
    <dbReference type="STRING" id="86630.A0A367JFM8"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HBS1-like protein N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="11148" checksum="BACFBD6DCA75A13F" modified="2018-11-07" version="1">MSRHRAIRNLDINDVLDEDDYESSFEEEEVQDEFDESQLTNEDLDLLYEGLDYIHAAIGKNDVLSDRQIKETLWYYYFNKEDTLDWALGIYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG28</accession>
    <name>A0A367JG28_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001389">
        <property type="protein sequence ID" value="RCH88880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG28"/>
    <dbReference type="STRING" id="86630.A0A367JG28"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="240" mass="28049" checksum="69D97F70AA19684F" modified="2018-11-07" version="1">MSAITEEDLDKYFSQTEKKVEVERVLSCFKLDPFQILELPYAKPDPKAIKMAYRKKSLMIHPDKVDHERAQDAFDLLKKAESELTDESRLKLLLTVIEEARVEVLRENGHKVKTEIQVKPPTLTTDEDGNTKLSASLDSILVVDEKEYPYLQTEQGRTKVKDKIKQILFEMELRKRRQLKKEMEAEGAEKKKAEEAALDRKRKAEDDKKWEESRDTRVNSWRDFQKKGGKKVKKLRKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGZ8</accession>
    <name>A0A367JGZ8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001325">
        <property type="protein sequence ID" value="RCH89232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGZ8"/>
    <dbReference type="STRING" id="86630.A0A367JGZ8"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017059800" description="NodB homology domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="148"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="413" mass="45729" checksum="F61C0B57CA5E9696" modified="2018-11-07" version="1">MWKYQALLLSLTSTMALGAVDLSSFPTKTDPTNVNIPKIPQTTSYDVATECTYYQSNFTYQKDQWPTIWDIATSNGMNTSAEFTQLYNSIDWSKAPNIPVRTLNPQGGLNLAGYDTVNDPACWWSATQCTKPKQEGINADIVNCPEPETWGLTFDDGPNCSHNAFYDYLAQNSQRASMFYIGSNVLNWPYGALRGLKDNHHLCGHTWSHKMMTTLTNQEVLAELYYTAKAIKYVTGVTPLYWRPALGDLDDRVRWIATQLNMTAVLWNLDTFDWAAGTTPGVTADTVNQKYLNYIQMGTNGTFATHGNIVLSHEINNMTMDFFVKHYPDIKKAYKHVTDVATCMNISNPYLEKVITFPSFDASVTKNATPATGSGVVPGASGTPSSATIQAVIPEFKASLLIASLFAALLVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JID2</accession>
    <name>A0A367JID2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homing endonuclease LAGLIDADG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001249">
        <property type="protein sequence ID" value="RCH89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JID2"/>
    <dbReference type="STRING" id="86630.A0A367JID2"/>
    <dbReference type="OrthoDB" id="2307725at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051289">
        <property type="entry name" value="LAGLIDADG_Endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181">
        <property type="entry name" value="INTRON-ENCODED ENDONUCLEASE AI3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181:SF2">
        <property type="entry name" value="INTRON-ENCODED ENDONUCLEASE AI3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016686921" description="Homing endonuclease LAGLIDADG domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="2">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="313" mass="35468" checksum="BD5263D555D6FDC3" modified="2018-11-07" version="1">MLFGLGFVALFTIGGLTGVVLANASMDVAMHDTINFVKNGAVLTLEFHLLSRIKLPNNNLDTSYLGPFTVGLIDGDGSIQVNHWRSKTLQYRIVVKIANRPFNENILQIIAKTYGGNVKLDIKNDFILWIVNDQQTIRQKIIPLFTIYPPLTTRVTLQLAFIIKAINGITIEEYFVTRSSKFSGRQAITSLFTTVPIYFAPWLSGFIEAQGTWVRRISVPFGFSFSITQCHDRYLVEAILAYFGQSHLKVQVPRVRINRMPIYQIEISNRIGVEKVVQHCLDNPLLGYKYYQLASAIEDSKNLSHLRHSSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIG9</accession>
    <name>A0A367JIG9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ergosterol biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ERG28</name>
        <name evidence="14" type="ORF">CU097_011349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001243">
        <property type="protein sequence ID" value="RCH89686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIG9"/>
    <dbReference type="STRING" id="86630.A0A367JIG9"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH89686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="16749" checksum="DC0A80427EF262DA" modified="2018-11-07" version="1">MESFYRQFIDIFSTLPEGYLPKWLLFTSALGIFNSIQNFCTDTLTKRVYANKPHEVTPLSGRLFATWTWSVSMIRIYAAFHLEHRFMYNLAIWTYVIALTHYAGELLVFKGCKLNGPFMSPLFVAVSSLFYLIQVKEEYIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIW0</accession>
    <name>A0A367JIW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SEC31_1</name>
        <name evidence="15" type="ORF">CU097_000338</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001213">
        <property type="protein sequence ID" value="RCH89873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIW0"/>
    <dbReference type="STRING" id="86630.A0A367JIW0"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="14">
        <location>
            <begin position="241"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="465"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH89873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="509" mass="57310" checksum="8D81804CB14E0DC9" modified="2018-11-07" version="1" fragment="single">ATQIVTAAHDGTISLWDLRHAHAPEKVMKSQDSVFDLSWCKQDSNLLLSGGKEILCWNPNLGELYGKLVESEYSLQVAWCPYHPSIIASSSLAESVDTHPIQSLKLRSPPRWLRRTTTASFGHNGKVAVVLKHKVLVTTVEIDPDIIKRSEQLESATSDLGSVDTFIKDRIRESCDKEDWTILKILFADDAREQLIRHLGFKRDQVIMSHQAPSPHSFFGKMVNPLPIRFLSSPLTDRSIAEYVGLGDFESAVDVCLASERFSDALVIAACHSPELFSRVQKTFIERYAHEHTYLHLLGNIVNRDLDSVVITAALDEWKFILATLCTFAQSGDLARLCELLGDRLMKAQKEKQALTCYMAAGHLAKTFNIWIARLEEKEKCQEEYTIRLQELVEKLTIFRKAIHYQESTSITSQGTYELARLYDTYCDYAQLMAAQGKLDIALKYISLVPEGYNKRVSLVPNMQQEHRDVTSTDHSAASTAVVPETVHPSPLAPPTSASYHTAPQQWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJ18</accession>
    <name>A0A367JJ18_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001211">
        <property type="protein sequence ID" value="RCH89885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJ18"/>
    <dbReference type="OrthoDB" id="2220587at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH89885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="209" mass="23909" checksum="8481CB3BB539D134" modified="2018-11-07" version="1">MNNNEEPDNDDIVLFSSGLQETKDGKLITTTEHLYEQMLVFNQKLEELADNDLPRMIKNTKREAIKKDLSEWLPAFFKNVAANVSLVGSKNVDLLEGFEEPFDESLERKKKDLEQQFNSLLEKRIHARRNIYDQMNLILQHASNNVSHTEDTTATTQSSPQLSEGPSLDSTEWDELKVEIGGMMTHLTNLSGDIESLIKEYELVEPIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJC9</accession>
    <name>A0A367JJC9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001192">
        <property type="protein sequence ID" value="RCH90006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJC9"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31956" checksum="13677AED96C91EAC" modified="2018-11-07" version="1">MYSPDQWEILSEVNSVTCITIVSLIFGRKLASIEGPIHYARALLLILYGLSWAFNLIACMLTSTNNGNFISCVMTHFNVALIATGTKIVLYLYFIEKIYILSMPKVSRLRSSLYLVNLGLLLPVFAVIILQIIFRINIVEADYPFHCSIGFELPASVISLSYDALLNILYAGIFIKYYCFPTTEQQTAHHSPSIRVMSKRNAIAAVISLLVLCINYIILICFNGSERGLVASSLVAIALTIICTTIHWVTTHPAESQLSAKNADKSYPLEIKQHQEVVVLTEFNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJP3</accession>
    <name>A0A367JJP3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_009072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001167">
        <property type="protein sequence ID" value="RCH90160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJP3"/>
    <dbReference type="STRING" id="86630.A0A367JJP3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07078">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="477" mass="53030" checksum="B5ED73AE50F20FDD" modified="2018-11-07" version="1">MSKRFEFLFKTSVTPYIHGRFLKSHLGCERVLINPVNEERLCSYYETSIDQLEAALVSSRSVTEEWTSNHRYRRDCLLKLADRIAQHDHDLAVVESKQTGKPIQDALGEMSDVIDCFRHFAGYSDKLFGTTHDILTFTVREPLGTVGLITSFNYPLLLTGWKLAPALAAGNRALVRPAPQTPLSTLALADLATDVLPPGVLNVLPGGDVHVSQAITRRTDKTSFTGSTQVGQEIMRQVSETMTPITLECGGKNAVIICEDADLSRAASEVAAGAFSNAGQNCCAISRVLVHASVHDRFVEELRGHVQKWKPAVCDDYQHDELLYGPLIDKRQYTRVRKYIQEYPQDPIMVGELSEEKGYFVPPTVYANVQDDATLAQEEIFGPVLSILKPFETLDEAIERVNQSPYGLAFGIFSRDYEKTNRAARKVKAGMVWINTYNLTLPSLPFGGTKLSGFGKDLGKASLDEFTFEKTVMMHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKH4</accession>
    <name>A0A367JKH4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_009349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001130">
        <property type="protein sequence ID" value="RCH90385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKH4"/>
    <dbReference type="STRING" id="86630.A0A367JKH4"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="188" mass="21495" checksum="0D087DDE52FA3AAE" modified="2018-11-07" version="1">MSEDYEGGRPRDDGIIRYGDHISLKHILTGRFLTSKNETYNSGSYQQRVFTADYVSDESTWIVLPPVVTEEEPGYEVGWDDPVRLKHVPTRANLHSHEVPSPASGQQEVSCFGNDENTDDNDVWKVQQFDEDDEQYDDFWRVGQPFILRHEVTGKLLHSHDVALEEGGNEVTGYEGTDDNDKWVVSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKZ4</accession>
    <name>A0A367JKZ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CKB2_2</name>
        <name evidence="4" type="ORF">CU097_007887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001096">
        <property type="protein sequence ID" value="RCH90607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKZ4"/>
    <dbReference type="STRING" id="86630.A0A367JKZ4"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="218" mass="25602" checksum="E3675A738D51E349" modified="2018-11-07" version="1">MASSSGSESEYAKYWIDWFLDTKGNEYFCEVDEEYILDRFNLTGLSAEVPQYYTEALNMITDNFDEESVDEKVREEIEKTARHLFGLIHARFLITNRGLFKMLDKYKRAEFGRCPRVLCNMQSLLPVGLSDIPMTKTVKLYCPRCEDIYNPKSSRHAAIDGAYFGTSFPHMLFQVYPNYLPSKSSERYVPRIFGFKVHSIAEQHRWQDQYKEQQFKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLR9</accession>
    <name>A0A367JLR9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001090">
        <property type="protein sequence ID" value="RCH90641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLR9"/>
    <dbReference type="STRING" id="86630.A0A367JLR9"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00538">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="78"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="303"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="83568" checksum="872455CBA286D521" modified="2018-11-07" version="1">MSIQIKSIPQEKLSLSSEGGTSHPIIRHLSKHPAVVSINSVSKLTQPQWFNGSPNYTFPYPNSVSQAYDVHGQLKLTGEGILIGIIDSGSCIDYTHPALGGGLGKGYKVMYGRNLVSAKGDEKLGIKPRGEFDPYDPCTGRKTGHGAHVAGIIAGYDVSKNFIGIAPNATLAVWRVFGCDHRVDDDTVIKALEMAHEAGCQVINLSLGSENGWIESPLAAAVERMSKAGIIVSQETMDGPFSISSPGTAEGVVSVASINSPYYPAKVFEFSTFPGEYFSYLPSSSTQSFPDGDLAYVIVNGSLPYACKSDMQFLTQFPMFGKILLVKRGHCKFNKKLKNAKLLGVKGVLFYDPNTSAHDVVKAETHSGTLPCAGLEYATGSRLVTYMMQRQDVIIKLKTAKEEHIIDGGPDLRISDFSSISPSYELHMKPMITAIGGNVYSTVPSRIDNGWSVKSGTSMASPQVAGALALMLEYYQKTKRGVTGAFLIEQLQNHARILKKESGIPYHPLIQGSGLIQGSIQMLPANTTDYQINKAQIDDGHFHVALQFTPSSTAVIPTLVSVKIDVTVLVNNHMMVCYPFPMYGGFIVVKDVLSKRALSSVPYFGVIGNMKDVPIFDKGYPYMASEKNITEKANFPYLFTLTRSKSWPTTVIRTVTGTARIEIRLLDKYGNPIGIIHNGLHTYKARNGLASKGYTKYIWTGDYKPTCNTGKYVTKYECDNTHEVCAKEGSYYLLLRALKHFGDPDNKDDWEEWKSGEIIVQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLX2</accession>
    <name>A0A367JLX2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ERGIC3_1</name>
        <name evidence="9" type="ORF">CU097_003352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001083">
        <property type="protein sequence ID" value="RCH90691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLX2"/>
    <dbReference type="STRING" id="86630.A0A367JLX2"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="149"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH90691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="391" mass="44722" checksum="3B5AA12899BE9126" modified="2018-11-07" version="1">MVSSSFIKRFRKLDAYAKTLDDFRVRTATGGTVTIICGITILLLMLFETARYLTPVMKPEILVDGGKMEKLPIKFDITFPHLPCYMLSLDIMDESGEHVADYDHDVYKERLDPEGRVILTEKSNDLSNSAAKKARQHSSEVPDNYCGPCYGAKPQEECCNSCEEVQRAYADVGWSTDPDNFEQCIREGWKEKAQAQAKEGCRMHGTISVNKIRGNFHFSAGKAFSQGGSHIHDMSQFLHNDQNQNFMHFIKHLQFGQHEYHSEKQKRTKSNELIHPLENTKWGSANAAMMYQYFLKIVPTEFHFLNKKRIRTFQYSVSKQDHVVNYFGGLPGVFFMLDHSPMRIIYSETKMSLATYLTNICAIIGGIFTVASVIDGILYRAERISKQRKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMK1</accession>
    <name>A0A367JMK1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001011">
        <property type="protein sequence ID" value="RCH91157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMK1"/>
    <dbReference type="STRING" id="86630.A0A367JMK1"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24574" checksum="4B36E5347277EF41" modified="2018-11-07" version="1">MRPKKYHLNIAEYPTELLVKIVADLLISIVKENDKLSNQSVTHFHSRTVPPIGIYAYLSRILKFTSFSNEALLSTLIYFDRIAQHKGPNYAVNSLTVHRLLITSILVASKFTSDVFYSNTRYAKVGGIPLCELNQLELEFLFLCKFDLHVKLENMQAYGDQLLTHALTQQDKNITSFPLSPPLEDNCKRKRPIDDHDTRISNKKLVCPIYYTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMX4</accession>
    <name>A0A367JMX4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000995">
        <property type="protein sequence ID" value="RCH91268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMX4"/>
    <dbReference type="STRING" id="86630.A0A367JMX4"/>
    <dbReference type="OrthoDB" id="2290427at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="268" mass="30958" checksum="E1B419484CC8A741" modified="2018-11-07" version="1">MALSGYLRSYYWTAFTVQLFGAWMECIFGGKALENRFGYWQVMMAKYGGNNPFFLRKQYRDKLSLSILEAKDINPRDCLDGELIDMPYKSGFARAVDIIDFLLYIVPTVYTDALEDQQNAVDMKIARRWQQNQIINPGDYVQREATNNICSALKAISRACRISQKYVLITMTYRTIRSRKLQLEVLMTHIGTKGFTINEHLLLHLHMVARTLGPPRYFSAQPLERMIGKLKQQTNSRPQPGENAANIVRAHNADAYNRMHHPLETIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMY5</accession>
    <name>A0A367JMY5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001001">
        <property type="protein sequence ID" value="RCH91229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMY5"/>
    <dbReference type="STRING" id="86630.A0A367JMY5"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF9">
        <property type="entry name" value="DCD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="374"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="574" mass="65622" checksum="F8931F76138B5AF3" modified="2018-11-07" version="1">MNSPHPNSPHVTIPSRDRTPSSNGALMVEYSQPIRTTGERLGSLVGASLTTVGDSVYVFGGFDQYTDEIFNKLYKLEYKDTCHWTQVIYTKGEPPIKRHDHSATLWNGNKLIIFGGNSEEDRYFNDIVVLDLDTLTWHHPETAGFIPEGRIKHSATIFEDKLYIAGGVYADSTSSFADTLLVLNLQTWEWERPIPFTRRAQHMSFVYNKRLYLYGGLREDMSRSNDFTFIDLYRPDNMTQLDITSTSSPSLLFGQRFAQICGDQLVVLVTIPFREAVITAPATGLWTLDLSCMQWQCRELGERYETCSWHCFSMTENDKYFYLFGTNEDDPEEFYSMTLRVDLEEVGVVPVPPPQLGHDLLRLMKEENKKGQEPNFTICSSVEPDEPGISVHRLILLARWPYFVSLWDSGMSEAVNNKIAIAEPLSTLRGFVKYLYSDSIEDENEFSTELVSDLLVMAHIYMVPRLSALCVRRLFNEIDIETASKIYHSASLSEQKGLQQAALHYIFQHFGAVSHTAAFRSLPRPILFQIWDYMPENASIVGRGQQDMYQQSLPATQIALLENENREDDLEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPF7</accession>
    <name>A0A367JPF7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000915">
        <property type="protein sequence ID" value="RCH91824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPF7"/>
    <dbReference type="OrthoDB" id="2237583at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="11469" checksum="EBA787CEE2F0653A" modified="2018-11-07" version="1">MGKAKRDQQKKTTPYSRPTTIKKKPITKAEKLKNKSITEDLDKNIEELTQQLIPKKKKQIQIRNDDMDNDEKIERQQLEYEKTQNDLDDALSLLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPV1</accession>
    <name>A0A367JPV1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neutral amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AVT3_8</name>
        <name evidence="8" type="ORF">CU097_008514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000905">
        <property type="protein sequence ID" value="RCH91899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPV1"/>
    <dbReference type="STRING" id="86630.A0A367JPV1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="42"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="446" mass="48830" checksum="74478E0446C0097C" modified="2018-11-07" version="1">MSQYIVEAKPGSHPASINNEKQQDNFEASLCEEQIEHVPQGTASPGKALFMLLKAFIGTGVIFLPGSFASGGLVLSIILMVVLGSLCLLAFQLLVQAQQKIGGSYGDVAEHLYGRYLKILINFFLCISQMGFVSSYMIFISENIGIVVNTVNHCNAPFDAKYYIWIILAAIIPICWVRKIARLSYVAIIADTFIAFGLICILYFTSSQIAQHGPGNNIVLVNSQDFALMIGTAVFSFEGIGMVLPVVEGMKEPKKFPLVLTIGIFICIFVFTLIGTIGYVAYGDVIQASIVANIPRVPLSTTVQVLYACAMILSSPFMLYPPLSIIEKAVFRDRSGQKSVTVKWLKNFVRSLIPIVCAVISFSVGSSNLDKFVSLVGSVACLPLCFIFPGLFNFKVTKKKYLRAIDVFLVIFGFGVMVYTMYININSWVHPVPKTGPVFDLDGCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQX4</accession>
    <name>A0A367JQX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rapamycin-insensitive companion of mTOR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_001416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000841">
        <property type="protein sequence ID" value="RCH92347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQX4"/>
    <dbReference type="STRING" id="86630.A0A367JQX4"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="3">
        <location>
            <begin position="186"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="38988" checksum="36C4FCF9A9C5F1D9" modified="2018-11-07" version="1" fragment="single">MCPSPSLSEYLSSTQSRDVVESEPTKNLTAIKQELETLLTRLDKEIKLKAGVENMLEVYVKDKKRTKELETQLEECNEAINKTTKAIENIRRNAGNNIVEIAKILKAHKFVGHGFSITPSSLEQTRSRLKSLSASKQKIPQEHVSFPDDDAWSLDKKLDHIIHTLQIDEWKAGNKSGNTIKDSKMEKLETLIRILKNTTDLSAYCSKGKLIACLRQCIVSPIKEIRIMGLRALRLLVEGSDDIKLMMDYQIDIFSMRALARDQEEHELEREQTLKLIRSFVEYNGVKHVKQGIVRAVVAIAEQQDSKLRNIALETLAELAILDIELTVKAGGLRVIMQALIDGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS29</accession>
    <name>A0A367JS29_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_008056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000789">
        <property type="protein sequence ID" value="RCH92718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS29"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH92718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="44250" checksum="03047E102CEFBD53" modified="2018-11-07" version="1">MADKYAQSPLLDITLPPPVILPYTQLILLYTSVIGIDLVLLRNDKRLPLSPIQLRLVLACIHAILPLIFVSPNRPFNVLYAAMPWFIVSYSAHMSTDQLTPIAWIDTLIKIMVEPNDNHTSRIRCRGAATSCLGILKWSFMHLFIDPLLPHRTLFALYYPWLHPMSLIYVILYGVKAYCLLGIVDIFMGLEQIITGWNMVQLFNSPILATSPRDFWSRRWNRAVRNLLHKQVFLPEKHTPVKRQELQRKSSSGKNSMDEEQEVFVVVERTHRKHGRKSKHVDKHASTGLKSFFSSRYGRGLLVFIISGAFHEVIIMSTCRKLTLENFAFFTIQGIAVSLEAALRQGKLKQEPEGRTRVVCIAAQLCFMALTGRLFLGPFLRYEFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS54</accession>
    <name>A0A367JS54_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000789">
        <property type="protein sequence ID" value="RCH92715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS54"/>
    <dbReference type="STRING" id="86630.A0A367JS54"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="168" mass="18889" checksum="0EC309C27A8E6D77" modified="2018-11-07" version="1">MKQKVALNRALSMTRLGELSSIYVPIYTPTKTSLQKSHLQSDLVFNEHSRYHTSAIIAAAIETNSLPFRLKKNAATLAESVSRLTYVRNTKLATLSVTLPLLKEKKGPLSLLDYESNVDKDDIYSQTTIVRGSEQYAFSDPTNPLVVNYHVETMLPLPESYPRLFPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSK1</accession>
    <name>A0A367JSK1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-dependent kinase 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CDK20_1</name>
        <name evidence="9" type="ORF">CU097_009649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000761">
        <property type="protein sequence ID" value="RCH92934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSK1"/>
    <dbReference type="STRING" id="86630.A0A367JSK1"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="33854" checksum="50F647BF1C29DD36" modified="2018-11-07" version="1">MIGTFASVTKEVTPESTLAIKTYSKQHGKLVLEHYQREVKALKRLDLKDANSAKEHHIVYLFSIHETPSSYQLFLTWYDYNLRLYLKQPQTTTRHALAHSFLQQISQGLLFIHSHGIIHCDISPDNILIDSNGNMCIGDFGCSRMVNEEDQPIQNEVIGTRWYKAPEYLFGYKMYAPSTDIWSLGATFTELLIGRPLFQGNSDLEQIGLYVKTLGVPSKQVQKEMSIYPDANKLNFFDMDDPDSDMDDEEYEESPVKPLEEVLEHANVDMNDRILIQNMLTWSIKDRFTIEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUT8</accession>
    <name>A0A367JUT8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01000665">
        <property type="protein sequence ID" value="RCH93710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUT8"/>
    <dbReference type="STRING" id="86630.A0A367JUT8"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="465" mass="54004" checksum="E20C60FA2DFEED53" modified="2018-11-07" version="1" fragment="single">PLSATVRWTHTDNSNKRYQGLLAPFFAPSAEEAAEDVARRHYPRLTAYDSAKCTSPPTRTQMLVRDFIDDSLYNPNYGYFSKQAVIFSPEHDFDFNNMRDHLEFMNKVGQLYKDMEEDADEVDEVARQVWHTPTELFKPWYGYAVAKYLVSEYKLSLFPQKDLIIYEMGAGNGTLMMNILDYIQQNEPEVYQRTQYNIIEISGKLAERQSERQGMRELRDQHTCVKIINKSIFDWKTQVPEECFFLGMEVIDNFAHDLIRYDLDTLKPYQALVSTDAKGNYTEVYEPVGNDPLISKYLTLRSQTGYRSPVLSNQLWLKFLQSLPLAPNMTSAEFIPTKLFMLLETLKAYFPKHRLVLSDFSSLPDAVEGVDAPVVQTRYRGTMVPCSTYMVQPGWFDIFFPTNFELLRDMYLLVCRGSSAGNDKSVKVLTHREFCERYGDIERTTTKSGENPMLMYYENMKMILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVB7</accession>
    <name>A0A367JVB7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_013063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000645">
        <property type="protein sequence ID" value="RCH93876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVB7"/>
    <dbReference type="STRING" id="86630.A0A367JVB7"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="275"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH93876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="605" mass="70031" checksum="BC55A63BA332490B" modified="2018-11-07" version="1">MNGLTTQFGYQPGNYYELRLPGLQMMSVAHVAQYDMDEPRLRVATLNSWKRELATHDVGVFFEATLTHLDLLSHYIQAEHRRRQRDAMQMASDSLEQDIQTLQKQIEKDEQDMLRMLRETKVNELNDFRRYFGVQSQLILENLAQWQKEKCKEVIDDCGWDKPDYIRDASVHSFPGSAVLVREDEPTSVIAYTLSSNEYVQELMQEGQSSNKSGMVTPNVAFLSTPGAQLPVTGKNSQVLDRYCSSIERKYVSPTASTETSSFRAMIIEICKSNVSEERLEDLKNILPWTKKVTEKSSTDEQTKELMATSSVGNKKGHNGSLHIQHKFVHNDVEFTCIVYYANEFEMLRRQCGVHQIMIESLCRCQSWVASGGKSKSRFYKTQDDRFVVKEMMNVWNVSEKDAFLNFAPKYFNHMKKSRQSALAKIFGFFTIEIKKKESSLYLDVLVMEHLFYNQHITKKFDFKGIVERHVGEYQKEQKDITLWDGDWLNEYKTKLLVQNKSLFDDTIANDAEFLSQCNIMDYSLLVGVNEEKREIMIGIVGAYTWYKKIESKGKSTIKRVVTIVPPGEYKTRFCKEILNNYFVPVQGKFDMSVKTLLSDKLTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWH9</accession>
    <name>A0A367JWH9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_010185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000594">
        <property type="protein sequence ID" value="RCH94290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWH9"/>
    <dbReference type="STRING" id="86630.A0A367JWH9"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH94290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="24268" checksum="09F7291787188946" modified="2018-11-07" version="1">MSLDSHYSPHYSDEDSITTHLSTPTSPMEAPLFGQFTLKTSTEKVYICSECNHTFHRAHNLKSHQITHSNSKPFQCTDCDKQFLRLHDLKRHQKLHTGEKPYQCATCLRSFSRLDALNRHRKTETACLKSNQLKPIVFPSSLPNPGTFLLEPTTQPTSSASLPTNTIKLPSLVIHENIDEIERLKQRIHDLEIENRVLRSLIRNEETVGQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWV1</accession>
    <name>A0A367JWV1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000583">
        <property type="protein sequence ID" value="RCH94387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWV1"/>
    <dbReference type="OrthoDB" id="2208838at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="124" mass="14474" checksum="F0DA6505E1D76399" modified="2018-11-07" version="1">MDIKRPSLYTRLRHASKFISRRTDRRKHQAIEPEIDVDQETLYEEPIEKYKWTCLDEDSDSIDDHYMDDMLESYTNTLDKLSGISNTQSNTRNTAVLIVLSPCALAAGNIARQRRKTHKPCIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYU0</accession>
    <name>A0A367JYU0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000536">
        <property type="protein sequence ID" value="RCH94821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYU0"/>
    <dbReference type="OrthoDB" id="2241755at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37958" checksum="DC58F0AE404406C6" modified="2018-11-07" version="1">MDVVNEKQKHVENFLREAFSNITDQYGQKLSIAPALPNLVQVTLNYESPLAKRFRFLGEGARAMAIRWIISSMFPEANLETLTEHNRKCQDPGRISKSIFGQMQFKRSLGIPTHSNLFDAYIGVLYHFFGMPAVRGFIEPGVKEIFSNPTTVKALTPGFKPVPNQDPKSQIREVLVLTGGNIQIDIQGAENSMWQATVICQLVQSGTIFSHSRIGPSKQKASTAACYDILEYLHNHVDIRTQLMIPNCDTSQVHRLNIPESEWCKVVDNVKTIIDSKVVLDNHPNKANWVHLPATDDQEETIRQLQLLLLGNGNPTNEIQPTRTGHFDTSIFSRPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZU7</accession>
    <name>A0A367JZU7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000466">
        <property type="protein sequence ID" value="RCH95448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZU7"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="451"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="548" mass="62865" checksum="D3F5E6174B8D5465" modified="2018-11-07" version="1">MSQQKSNHSKLNNADDNAISVIKSTDSDNAWKAVGSRRGSTVAVEKSISPHDSPINDTTETIRRSSIASESNWGSFNGFQWEGPSIFEEEGKSTAVTSIAPTTALPEDAIPSSVLSVPMLPGVSLEPIYRQQRSLSFSMGQDPAFFGYDDYEEPYQHVQYKSSLEPMAEEQEEEEFDSLDLSFIRSRSKSSGAAFGLLSQSQHAHLLARRESEHLEDIQQQRRRSSRFFHASEMSLGDKEQLQRRMSQQQQQQQQQQQQQEYAFPDNSNYNLMRRQSLTLNTPPPTNIQQLADQLENTHIYHYPQHPAPVPFRSDLFNPSFMPSSHPHQPTAPMAVPSPPVPHIIEDLDSKSLNELGKGVPISRLDAPLFMVEFKASRTDFFYSPHFYPRIGDLVIVEGDRGKDLGKVVANTLTVDQVTELEQKKQARLESANAHEDQQQQQQPKKEIHIKRIFRLAAPDEIQMFIMKAQDEQKALEICQQRIKQRKLPMKVVDAEYQWDRRKLTFYFEAEHRIDFRELVRELFKIYKTRIWMCVVTVPITLNDLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K093</accession>
    <name>A0A367K093_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000479">
        <property type="protein sequence ID" value="RCH95321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K093"/>
    <dbReference type="STRING" id="86630.A0A367K093"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="31656" checksum="ECD7FFDABB2D70C7" modified="2018-11-07" version="1">MIQNNNIVTAPRVPSSPSVNYYDPRGHPFYTHQQSAPVHNNHYLNTSAPLHSTVNSTTAAAAAAAAAAAAVGVDLNTSLPPLSRLLPPTVNDSRTVRSQGVYKTPPLGHRFDDVYMVHQHMPYNDVFHPPSVRSHQLPSPPTSVIDSVLMSGDALTNHHQKVFSFVPLPGVQQKKRPRRKYHEVERLYKCNYQNCTKAYGTLNHLNAHVSMQKHGPKRLPAEFKELRKMWRKQKRENKREKQRDGKDEEYNSFLPHWSPDKPTTTTTFRTNYGFMPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K098</accession>
    <name>A0A367K098_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000452">
        <property type="protein sequence ID" value="RCH95569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K098"/>
    <dbReference type="STRING" id="86630.A0A367K098"/>
    <dbReference type="OrthoDB" id="2285422at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="45431" checksum="1A176ED33813F129" modified="2018-11-07" version="1" fragment="single">MPFDTIDTPHHHYQIPLDDIWSKLNVSYTEAGINVETNVTSASDLHSLIDAFGKLCNTNPPDPAYSPTTVSGITPLYRNKSHQSKPVNYFICTDKLGKRITPIRQNNGQLQDIADACIHTYFECWIRFTPILSREEFMQWYISHPNPTSTLIVNAICLFVFRHMVTHHCPPELEHYITNQDRIQEQEEYFFEQAREYLAQTFDHPDRFTIIALSYMMSRAEPSRRHQYAGMAVSALHQLDIYPRLIDDDDMSFEKEKDTRLWWFVWAWDFYMSSSGAPKNTPQPRVPGKEIDLPRVMEQDIDNGELGMLVFIHCLQIWKIQSRIITTFYEQAVDMTLEQLHAYDKQLLEVYQQLPCYLKGQSKNHDVLLASIRVHLEYNATRIILHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0L8</accession>
    <name>A0A367K0L8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000438">
        <property type="protein sequence ID" value="RCH95720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0L8"/>
    <dbReference type="STRING" id="86630.A0A367K0L8"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="33388" checksum="7E9D5F39B76F7A9F" modified="2018-11-07" version="1">MRFKASANNPVGLYKIAQTLEKFGPTVIMAMSIETIMFIRHRDHDAGIQAWIKLQPQSLFTNYRIESANNNEINLFFRVSDLLYISKVAQQATNIMINLRLRDGQPYLNWKMTLQDRNGSSMESVQELGVSLISPDRMVYIKEPRTMGIPHTYILLPNVSTLKPVAERLKSLSKYLTLSANMNGVFKVAIETVNCECEAIFEGLENPQLEGQQPNEDVNEFAHVRIASDDFVSFLNCYHLDPQNVVCSITDELQLVFYVYMTIDTYQAHEAPIRPIHSPQTIMTCHVPAYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0W8</accession>
    <name>A0A367K0W8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000455">
        <property type="protein sequence ID" value="RCH95541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0W8"/>
    <dbReference type="STRING" id="86630.A0A367K0W8"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="420"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="802" mass="92848" checksum="C655C8C9262ACDB3" modified="2018-11-07" version="1">MPGATSNKAEMDKIATSFDRMSVNDAELPLAGTDLTFSAALDDTENIEQLGPVIKNIIETGKRTAFLDSLDALIRKKDAEIERMCNIHYQEFVSAVDQLLKVRQGSVELRKKLTDVNQALQIRGTKWAARKKELTNARKIQQNIEDAIEALQSSLVLLESANKVNEQLDQKKYYAALKILNNLQNDRLGQATQYTFAKMLAQGVPIMQNTIKATVTMELKEWLARVREISREIGQLAMQRMQERQDRWRSRTSENPRLKNLQHHQVNSAIEMVVNEGLETSILDEVNIDFEPLYKCIHVYSTLGKPNEFKASYSEDRRAQANLALSTPINLRNGNLTTFETLLQDIVGFFIIEHMILHNTTEFRSQAEVDGLWEMVTGKVILVVSESLKGCKDPELFLRIKFLLLMFIQTLEGFDYSVKPLQETLLTLFQRYSELLINQYSEVMEKIVQEDECMPMTVENEEELKEVMQYTRFRPDREFIKRYGFPLRLPFSKVFPTCCRDVSFFVHQFYQFAEGFSQTHGEMDDILKKAVDSLLIQKVNAILLKKLQSTNLSQIVQIIINIEYFESTCPDFEMLLMETRSFHRSGHIHLKATSTFKETRRKAEKRVFELVNSKLDEFLELFEYDWEAEEMQKQPSPNLQDLVTFLTNVTNAALLNLPETIKSLLYFDALEHLSQSMKGLLLDTDRQHMTEIALSNFDTDVRFVEDFVNSLGDPTLNDTFLELRQLLDLAILSDNPEEYLTPQVRNRKYNRLNSRDVVILFEKLLRTPLQIHSVLSQKERMRRKALENVARVLRSVHISGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K159</accession>
    <name>A0A367K159_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000424">
        <property type="protein sequence ID" value="RCH95879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K159"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016842532" evidence="2">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="10865" checksum="1DDF5E2FA6277C51" modified="2018-11-07" version="1">MQIKLVILTICASLIAVGFAAPSPQMPPMPGGMPKPPSPSPPGMPMPADAPAQPQALDPNADPNADPNADPNADPNADSPAPPSGGPSPQDADLGGLLNHPIYPFLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2H9</accession>
    <name>A0A367K2H9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000366">
        <property type="protein sequence ID" value="RCH96462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2H9"/>
    <dbReference type="STRING" id="86630.A0A367K2H9"/>
    <dbReference type="OrthoDB" id="10381166at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH96462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117459" checksum="E8E9E72E85DAD5DA" modified="2018-11-07" version="1">MSYRNKGNEPPGRPEVFERLGTVSSSDYNDYGYNSSYRNHNYNNSSSDYYRYRRRSPSLYYNDRYDDRYGDRYNGRYDDRYGYRYYNDRCSYRSLDSGLKIAKSYNNNNNNNNNSYHHKQDYYSSLSDKSRINFVKNDKKPISFVPNKSSEDSYDRREPSPTTDRDKVARDLQITVTRDKKSDHQEDKQDDAYNTSSVTSREIAMAPSQRSESSQRKSSSYKTDTKYTGNGAGTDNNTRSNSQADQQKSQVKRNQSPPNKSKLKKKSVDNNKNNSSVEVATPTTPTRKPAPSSLPALRETKSDSTVHLEKPPTEPAAMRNGKIAGLLDPSPVTTKNVNNLSTDSESTKRDSTTASKQTPTKPSSIRTTVNQKDRGNNPIKEKSDSQRKLSNTVNKPSLPTTNDPKSNTSAPSTKSAPSATAKTLNKQDIKTVQSSQLKVVTDNRLVSPNLQEQQKPKQQQQPVQQHQQQQAQKPKQQQQQLQQPALPATTVAHGQQKPIKHTEESTPTNDPVSMHAPSQASVEQQKKELEKKLGERHVEQLQQLLRLQEGEEELARERVNKETEADQNTITTLQELIKSSKEKQSKHEKQMSMFPPESQKWMEARNNIEVTKIFIKDLNDQHTKIMDSITSILNQQLEAIPTKFKELTRKAREEYDSEKKQIDDSFKIKKSDSSSSTKKNATSIKNATEPSATTVNPQVALLTNQRPTQDTMKQQASEQITSNSVEKQNAIPLALPVKATHTQVETGRVTPTPQKQTSPEPTKQTIPTSTASPQTINTAIAPKASKTDTNDTGKQNNVNNSPNNPISRKRRRVFADSAEASVIIDNDVPLTSPDTTTTTTTLAPSPKQQHIEKPIDEERVERAVKRHKCDPFILADHGTITPPLSASASAQSLNETNLPKDGRREPPLPIDERDDVVIDIFTKKGATHRQSPASTNPFTPQISPVEVPISDPMEVDQESIRNSNKTISAQETRIEEMDIEQPVTETPVDKKPVIVDSSTTSVPAKKPRTTTKVPKIWKVRMDDDTGDVYYQHRVTGEIRLDRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2I2</accession>
    <name>A0A367K2I2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dynactin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DCTN1</name>
        <name evidence="8" type="ORF">CU097_002101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000374">
        <property type="protein sequence ID" value="RCH96376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2I2"/>
    <dbReference type="STRING" id="86630.A0A367K2I2"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH96376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="25418" checksum="45960181294B3F9C" modified="2018-11-07" version="1">MPFSLNPLRKTQSTGDIHIIINNPKIPEGILVKKGQPIPSTSKPDPPQRNHEIIQDRLNDITANDMELLLTLETQARMDALEEESKRQRTLRFEIPPHPRSTELVHKRRWSAPDDWISALSATALKNHLSKWMHFQRRSSSEDHEDESSTIQVGSRVKLYKRPMPIIGVVKYKGPVCFDQGEWLGIELDSRVGNTNGSIQGNHYFQTSPNRGLFVKVEDAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2M9</accession>
    <name>A0A367K2M9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000370">
        <property type="protein sequence ID" value="RCH96420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2M9"/>
    <dbReference type="STRING" id="86630.A0A367K2M9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="292" mass="32666" checksum="48227AE1EE60388A" modified="2018-11-07" version="1" fragment="single">DEGKGKSVLVSSPDHYHNLVNESNLLGMNEQMFYHARSAEAISHNIDQLEHNVETLAAQLGINSSLVSDNFADFCSQAQTNHTVINSAYKNNRNLRTDTYESISDFSQQHEQQVMNPTTWFFGDYVKSIEQYPTTSTLMLEQNNNLTPSIRSTSPVANMQTSNPSSPIAINTIPTSLTGATNNTTYEISHKQKLYDQATMLQPHQEPFPQHCYTTVATTATPTAVLTAVKSTNKQFQQSNLPPFLTSHPFVKHSGQPNIHPHYAPHAKCHSPVVDTIEYEQTSEHEDDTIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3K7</accession>
    <name>A0A367K3K7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ran-binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RANBP9_2</name>
        <name evidence="2" type="ORF">CU097_013217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000340">
        <property type="protein sequence ID" value="RCH96750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3K7"/>
    <dbReference type="STRING" id="86630.A0A367K3K7"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="206" mass="23961" checksum="DD7FA68F16FCE875" modified="2018-11-07" version="1">MDLDCNLLVLDYLVHHCYGKTAKAFIENIKTLDQFAYLPSQTKHCKLNGYSIIDLINASIKDSIGQGEIHRALKVIKDHFPALLEHDELQHISFRLRCQHFIEIIRSGSEMEAILYAQKYLKPVRHEFKEQVREVTSLIAYSDPFQSQSKHLMSQQRRDKLAYEVNCAILDLHCLSDESTIEKIQRQYAVVTDELERIDIKEKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4B5</accession>
    <name>A0A367K4B5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000312">
        <property type="protein sequence ID" value="RCH97053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K4B5"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046804">
        <property type="entry name" value="DNA-PKcs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046803">
        <property type="entry name" value="DNAPKcs_CC1-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20500">
        <property type="entry name" value="DNA-PKcs_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20502">
        <property type="entry name" value="DNAPKcs_CC1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-PKcs N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-dependent protein kinase catalytic subunit CC1/2" evidence="3">
        <location>
            <begin position="841"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1686" mass="193832" checksum="4CDD380960078B02" modified="2018-11-07" version="1">MLDTRISHLDTSALNIASIYRRFSDMYTLPPTRLPVSVKAKVIELLGTIARFYPNLLNQNDPQILKRWCLDSLDYILNNTSSDYAFISGAVNCLNTLLSSKNHLIEPESRESDRLFNILLKLLYIPPDINRYIDTIAALELFTSHTHLFTNLILPNCEKLYKFLQICSTHQNRLVFKYGTFAYDKFLIALTEILCKNIDGDRERSVFLFFMNDFMRSLELGNDLEHFYQTSAAIRGIGYFSKVCAHMLSKEEVENLCAELVRKSNWFYSDMNAEQHEYLRHLPSFLRAYSSFAGQLESVPNELIVSLYHMCDIFILNFVRMSGYHRVQGSAAIVGLLGMLYQRGEGLLRKFLNRFIDKALIYTCMDVEMPDGGTRHAYLDLLYFWETLLAKNSVKRLTTNPISLTEDEDSNEQVEQSESDEAAMSLDPEQPQSSSLPFLQVLYDVFFSSFLHMMKSFNLSLMNTEADDAEETNLNIITNTLRPINQKDFLIFQNFIEFWCMLLKKLENERLFDCMYILGTSIIDQSIQHPLVSGFYKMLAEMLAIAKKNHIFDNCRKHYIDSELMDEREEEKQDVYVTYLAFQGYVKEIWYRLQQFTDDLLASCLRLVLIYATAFFSVEELISPLEKALHLGITYNPLAVVAMDTLDELIASKTKYEIDDTFLSRILPCINEYLLIGMVNTSEYEDSTGIDGMKKRPYKILTAAQRRYAAVKTTTRKSELGVATREYTSLQELQLRMMRFLGRLGGKNKQLLINDKDGIQKNDMLAWDPVKRLKIHLPFQNAKVDIYMDEFLPRICELAESSPDRRVKVAACESLHSLIILMLGNSALQIRNTRNSIETNYYKLYVRIFPIMLCLAIDPDQVARDMFRLLNSQIIHWFTNNAYYENPETTALLQALLNASCNSDASLRDYGAECIQEFVKWSIKQTSRATDGAQNIKSLLKRLYNLMSHPSAIQRFGAALVFNRIYRLFREESVLVNEYTLEILGQLFFSLKLSDSDHPSMGTHDQIIEAISHVKRILREKTSIFLESNPMRRPFLDDDKVCDLPSVVTWAFHESGKHQRAYAKACINFFSEFVLKLPGVETGKQWLLKQMNQDPFFLTNIFETNHLEPPSVFILEEKLMTTYSSWISQLNVTVDGYIWLTERNIIDLAELLSQGSSVFLEAVSYFIRNAPEDVLQDKIEQNTIEKTKIRSLYCYISARLVYLFDLLIKSPGNEATCYSLINNNVSDILLHERFADVVANILLFPKKLSEDIEASQRNAVTNSSTSRIFRLAKHFMLTAHEKSYTALVDNIIQSMARIIINSDTSLAISLDDSRGRSSLVAMIGTAEAIEFVQSIGLLDLLCQKANEIEKKHPSTSNGYCSTLFSHYLTYHKINTEPLWTELLGKMISISFAQPELVVEEASIFLDFSGTCDISDAEKLSIFQKYRQHVYDAIAYNFAKVSTLFIENISHPLVADYLILLFGYYKENRISHRKAVASITDFLIEDPALLEAMVFEWNTPEKKLNLITCLELLFGADPGILIRAKRKRIFDFLFESFLKLLQKDNLNEVIRNALDLLPVFITLDGPYLEKITDALQISVVSQFPAVSAELSVGTRIYNEYIAVLDKLLNVMVSFKSVPIFKLLKGTFVQEEHHIHEQKIRDSIAKFSKNLGLFSFLDVTQACFEQKHTDCAQTEHHKPSNINASFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K535</accession>
    <name>A0A367K535_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cleavage and polyadenylation specificity factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CPSF1_2</name>
        <name evidence="10" type="ORF">CU097_009928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000289">
        <property type="protein sequence ID" value="RCH97297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K535"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="94"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="547"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1554" mass="174685" checksum="A889D9E7E203FAEC" modified="2018-11-07" version="1">MSAYTIYEELFPPQTVEQVETCHFTSPDAINLIVAKASLLQIYQFVEYVPNVEEEDETLSDNELAKERLNDTEDRNLTYPKLKPLKKDVVVDSTSGRLELVAQFKLHGIISTMGTVRTNSSRGKEGCDSLLLGFSDAKMSLLEWSSATNSIVTVSIHYYERDEFKKEFLANPNPSSIHIDPQQRCAVLNFYDNKLAVLPFRQTDKLDERPGDADEDEEKWPYQPSFVIDLSTLDSRIKNIIDMSFLSDYYEPTLAILFQPEQTWTGRLANNKDTVSLVVISLDLTAKVYPIIYSIDKLPYDCLKLVPMPKPVTGMLVIAANSLLHISQGSPGVGVAVNGYTKKTTDFPGMLYESELISLGFSLEGAKALTFGGDRCLIFMQNGNWALVQFKMDGSKVVGMDIVEIKHTIPLMVKKPHRFDTPPLLATVPSCITNVKQNEYFFLGSRVGDSLLIKYCPELMNSTSLRNDPQHVFRVCDTLLNTGPIVDMAVGDVQSHEKPQREDNNDSTLPELELVTASGHGKNGALCVFQRHIYPETSFSFHQFDSQAIWSIKCRKEQPYDVQKAAKEEHSRWERTKDNDAFDRLLFISKSKSTLVLSAGDELQELVGTGFYTRGPTVAVSTLFDSTRIVQVYATGVMMLTPEGKRVQTESIRGAKIIEASIRDPYIILTLDNNKILALQGDASTKDIIRIQLPNHIKDIGASLSGIFADTSGLFLSISEKAKVIEAARAAALQAAESKAQQQKKRKAEEEHVSMKKKMSKTAGTYEFDEVDMDLYGEEILDDGDSSTVVNNQVNEEAVDMPEATNEEKIDESNVSLQGVEINEMTRVSFWCFIYTTAGSFNIYSLPDFKECFTCPQFNIAPDLIIDNDQGQKPKMNTGNIQEILMTNIGKERKDPHLVARTDTNDIVIYKTFSYLDESATDNDRLALRFSRVHHEYVSKNTPSTTSSKKSKKRGIIDTFEVPDGDLEEEEEDLKTSRKTERKHLRKLLIPFTDVAGYAGIFLAGPQPAWLMCSFKSFVRVHPMKTEHEIVGFTQFHNVNCKHGFITLDSKSDIRLSRLRTDGVNYDLDWVIQKVPLGQTVHKIQYHPIMRVYAVLVSQAVPVRMKNDDNQYIDGKETDERAPGEFLPELNKFSMVMVSPVTWEIVDTVEFEEFEQCFSLECALLDSKQTSTGRKYYVVVGTGSLKGEDTTMKGSIRIFDIIEVVPEPDNPQTNHKFKRILTEDVKGAVTAMCTVSGHLTASIGSKVIVWSLEDDERLVGVAFIDVQIYVTSMSSIKNFILIGDAQKSIWFLGFQLEPAKLSLLGKDYQSFDVGCVDFIIDDKSLYLVVGDTSENIDLYQYAPFNLQSFGGQKLMRRGDFHVGSQVQTMVRLPQIEKSDKGLAYSRRHFCLCGTFNGSISVISPISEKTFKRLNTLYGQLVNNLQHVAGLNPRAFRLIKGPKQRMSSNRTKAVLDGDLVFSFAGLSIEEQKETTKQIGTTVTRIMEDLDSKTPVKLARVTKVLGRTGSRGGVTQVRVEFMDDTNRSIIRNVKGPVRENDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5B4</accession>
    <name>A0A367K5B4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain and WD repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BRWD3_1</name>
        <name evidence="5" type="ORF">CU097_009970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000286">
        <property type="protein sequence ID" value="RCH97329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5B4"/>
    <dbReference type="STRING" id="86630.A0A367K5B4"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057451">
        <property type="entry name" value="BRWD/PHIP_AD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF17">
        <property type="entry name" value="BRWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25313">
        <property type="entry name" value="BRWD_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="375"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="501" mass="57730" checksum="E2511F1E8D9C0BC8" modified="2018-11-07" version="1">MEVFVNVESPNRIQRENSYPIASSSHSAYDTRGGGSGITTRSSASHTYTDEQEDRKGKRILRSMANDVDNHEDNHGPLSPYSFRSHQNGIGSSSSISTHPPRPKRTRSQQMEPPKPPVQSKTTAKRVGKQRGFPRILSKDEIELFEPIPWIKNVERSVSKYLPQTGDHIVILTEGHRQYLRQSEMKDLFDEKHGVIDRHEPVIFAQVAGMSWQVGPPTYCKLKVSLLRLQNLQQVLSHQAAPNWVSLHREEVIDYSDEDGCPEFIILWERFYASMDVFRNLQVGQAVDAVYDESGTYSGTIASLNQKGLQWRQANLPSPWTYFHVVWDDPNSKPDDMCPWELVPHGENFYDKYDVGPRLTNEEIKRAKDILIWLASSEDFALYVQQVDYYQYPSYLTIVPYPVCLDMVLERLENGFYRSKQGVIDDIELIKKNAMRYNDESSAAHKNAIRMANFFKTRFMNPRMPLSWAKGGGRKKAIVDKSDDEYQEELQREEESEEEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7F8</accession>
    <name>A0A367K7F8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000216">
        <property type="protein sequence ID" value="RCH98192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7F8"/>
    <dbReference type="STRING" id="86630.A0A367K7F8"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="67857" checksum="F14ABB7F0AB387C8" modified="2018-11-07" version="1">MTENNNNYKDEKTMVEEISLKKSRPLPKIPERVSSRDIPTLPLNKIENVIDSFKNQKRLTAQQIFQTINNDDDNDYEEEEECSGVYASKTEIPTSTYILPEPSFFFSKKLMTPVLEVDEEDEEYLTLPPTTTDHYIIPEHADISDQGEPSLESGRTSPSSSIDSTAQAQETREILDDISTLNLGSISSPPFPLQQQQHQQEEPYNKGPLQNSLLMDVQNLSQINHALMTPPFQPTTVKPENTYFMNSPIPTMTSFSLTHDKASIKTFRRMANKTHDPQTQFTYAKYLIQLVLFYSNNNQTNNEAISSVSSETRERLQEEAEYWIERLAKSNHPEALYIKGHWHRFGQQYHLIGSQYKRVNHSKAFKCFQQSAKLGCTEAHYELAEYYVSQKEYRKAITSYKYAASKNHTLALYKLANILLRGLLSQETDVHQGLAFLKQAADAGSNQDCARPAYDLACIYANDLESIDLEKNSILSSWITEQYYPLAIQYFKKADELGMAAAAFRLGKIYEHGQLGQVKSDEEAFKYYTRAAEKKSHEAMLELSRLYKDGIPGYLSPHALMAYKWCLYATENGNEVAEYTLGYVFVIIILILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7P6</accession>
    <name>A0A367K7P6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000211">
        <property type="protein sequence ID" value="RCH98253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7P6"/>
    <dbReference type="STRING" id="86630.A0A367K7P6"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904868">
        <property type="term" value="P:telomerase catalytic core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045537">
        <property type="entry name" value="Lar7_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19977">
        <property type="entry name" value="xRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="5">
        <location>
            <begin position="226"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="334" mass="39286" checksum="E6246A56F934AA19" modified="2018-11-07" version="1">MSKEERQHKIINVLETYFSDASLLWDKIMVSKITADPEGFVSFDTLSKLQKFKAIEATPEEIKECSKIRSLNKLKLSEDETRIARIKPFIPNKKEELDEWSIYVEGLTKPYVDEASISELFTKLVGRVSFVHIPENKRGFKQFQGFCFVEFDNKESVYKAIKLTESTDNLKLKLRIMSKFEWNKYKEDYLKRFEERKQWIQGLWQEYNNKQQENPSKMELDKEETAYKKGVIVFVDHLDPKCSKTTAIELLQTSGVSIAFMTPKKKGLTSVHIRLESPEDAQRICDYFENHPTIQENEQDKVGKASKEHSAETLKLRVLKGREEEIYWENDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8R1</accession>
    <name>A0A367K8R1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TFB2_2</name>
        <name evidence="11" type="ORF">CU097_015058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000184">
        <property type="protein sequence ID" value="RCH98613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8R1"/>
    <dbReference type="STRING" id="86630.A0A367K8R1"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="395"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="468" mass="53766" checksum="B83C52857EC61F7A" modified="2018-11-07" version="1">MSVDNFKTSIYEYLETLPTITFMRLFEKPATCLAIFRLLPSVGRHLVMSLLYVQMPISISDIHSWVNKEGEKKLVEALQKLASLRIIEQKDQVLIMNDTFRRQFQNALTGGGTQQSFGLPCPTPDKHPVDINFLDHYATTQWEAILHYMVGTSLTKKPSRGVLNLLERSKLMQESPDNGGQLQITNKGFQFLLQDVNTQVWAFLLQYLDMAEVLQMDLVEVLNFFFQLGSLELGENYSVDTLTQTQLQMLEDLRDYGIVYQRKKHSKRYYPTRLATTLTSGKSALAAATVKYNHLAQTNVDQTADGGDDQGFIILETNYKLYAYTDSPLQIAVLNLFVQLHARFKNMVTGVITRDSIRNALMKGITAEQIIYYLQSHAHPQMRKRTPVLPLTVVDQIRLWEMERNRLKPTASYLYHEFNMQADFDAAEKYARDLGVLLWSNNQKRTMAISEAGHENVKGFVKRRLQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K997</accession>
    <name>A0A367K997_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MSS4_3</name>
        <name evidence="13" type="ORF">CU097_009991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000177">
        <property type="protein sequence ID" value="RCH98699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K997"/>
    <dbReference type="STRING" id="86630.A0A367K997"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="12">
        <location>
            <begin position="131"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH98699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="553" mass="64489" checksum="2409DE88B1FA9F96" modified="2018-11-07" version="1">MKSIYNSEICPTPTPIPAANQRPIVAPSTNKVEDNNIVQQSILKRHSTITSIHEEPIHTQSTTPPMSRHYSTGYTLKSVRQLLEDKERVDLMKRSEEFQKELNTRRKAFKRLSRLLTDDNDDKVLMGTRISEGHRNYVLMYNMLTGIRIAVSRVTAKIDRALTDEDFDAAHKLAFDVIGDELTPGAKYDFKFKDYAPWVFRHLREKFGVDPADYLISLTSKYILSELGSPGKSGSFFYYSRDYRFIIKTIHYTEHKFMRKILKEYYKHICDNPGTLLCRYYGLHRIKLPHGKKIHFVVMSNVFPPNKDIHETYDLKGSTLGRFLPEEEIRKNPYAVMKDLNWEKRQRKLQLGPLKRKLFISQLVRDVTLLSQLNIMDYSLLVGVHDMLRGNKDNIRDSTLQTFQPNTKSIQRRITQMRRRTSKAQVVREAIAGTNPHKLDVSQLPEETQERRRCIFYTDEGGFQATDENNRPLPVLYSLGIIDILTPYDLKKKSEHVYKSVTTKDKHGISAVKPTQYGQRFLEFMARAVLEHNDDIPHEFKLKSKAKHLFFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9A2</accession>
    <name>A0A367K9A2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HOM3_2</name>
        <name evidence="9" type="ORF">CU097_008244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01000168">
        <property type="protein sequence ID" value="RCH98822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9A2"/>
    <dbReference type="STRING" id="86630.A0A367K9A2"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="434"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="502" mass="54931" checksum="9433E6E60B4E3466" modified="2018-11-07" version="1">MQIELQMNSPQLPWVVQKYGGTSVGKFLNEIADTIIPKYLKTNRVAIVCSARSGVTKEKGTTNRLLRAAKEAITEGSKEHLNIVKEIRDDHINAARSVIKNPEILSVLEDQLEKDCLKLKSFLEAAEIIEEISARSKDIIVGMGEKLSCTIIAAVLKDRGIDSQLVVLSNIINQEFTTLDQSFYDYVAGRLKEIIHDCGNRVPVLTGFFGYVPGSLLNSIGRGYTDLCAALAAVGLQSQELQIWKEVDGIFTADPRKINTARLLPIITPEEAAELTYYGSEVIHPFTMEQVIRAEIPIRIKNVENPSGVGSIIFPDSLKRNGSATPPPSPEVLAQNGYHKDLSRKRPAAVTVKDKICVLNIQSNRKNVSHGFLAKIFTILDEHNIVVDLISTSQINVSMALSIDVTENSLSRALVELERLGTVDVIRDMAIVSLVGKQMKNMIGIAGEMFSSVAEAGVSLEMISQGASEINISCVVKEKHALGALKAIHQKLLDADPNLDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9J0</accession>
    <name>A0A367K9J0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MSM1_1</name>
        <name evidence="13" type="ORF">CU097_004999</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000192">
        <property type="protein sequence ID" value="RCH98501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9J0"/>
    <dbReference type="STRING" id="86630.A0A367K9J0"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="381"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH98501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="515" mass="58581" checksum="A52300D2B2FC838D" modified="2018-11-07" version="1">MGCFICPVPHIGHLYSTVLADTLRRYYILHGKEAILSTGTDEHGLKIQQAAEKNGMEPLDFCNKVSDSFKKLCEAANIQYTSFQRTTSKDHATAVNELWNTLLKNGYIYKGKHEGWYAVSDEAFYASAQVEEVTDEKTGEKIMVSKESGQRVEWTSEENYKFKLSAFEKDLLKWIDDNPKAIVPQNRKNEVLSWIRAGLADLSVSRLRARLNWGIQVPNDPEHTIYVWLDALTNYLTATGYPWKKDTALKDAFPPDVQVVGKDIVRFHAIFWPAFLMAAGLPLPKQILVHGHWTMNKQKMSKSRGNVADPFEVIDRYGVDPVRFYLIHNGGMADDADYSEAMIAQLYSKELAGQFGNLLSRATGKALLPSRIIPTRKDIDIGDETLHHMLLEVADKYHEAFEERQFGRALSLIVDLLSQANKYFTRAEPWNLAKKPEEKDKLDTVLWYSLETCRIAGILLQPVMPTKMNELLTGLGVSPEERYFKDAKKLVEKERPLGEMSGVLFPRIKTSIKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9R3</accession>
    <name>A0A367K9R3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YOS9_2</name>
        <name evidence="11" type="ORF">CU097_008742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000155">
        <property type="protein sequence ID" value="RCH98982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9R3"/>
    <dbReference type="STRING" id="86630.A0A367K9R3"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017066236" description="Protein OS-9 homolog" evidence="9">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="113"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="403" mass="47349" checksum="C1FD6D78C1A6F200" modified="2018-11-07" version="1">MLMKSILIAVTVLIQSTLASYFVSDDVLNLPRYKVSLLTTEKIPQSQLHDATFNDQTMLMRDSYGQPFLCNIPQVDRDEAEHQEQMEAETKDTHEDEQKLIERGLELLQPLENSCLQFYTHQYWAYEYCHKQYVRQFHVESVYDGRVERKKETASHYLGKYPGVTIDQNPIIENALLPTIRRDKTAKRPVTTLKQVGNQRYLLQQWGDGSTCDFTKKPRTVEVQYQCEYQGHDRISYMEEISTCHYLIVISTPRLCEEMKLSRIPKPRIHTISCTPIVSDKLIEAEREQEEQKQEQQPLIEEQKEEEKPMNDETKERVISKDPILKLLNDLNEQIDLLKSQVNGYSSSDDDINIMFIDEDGNYISSNSELKKLLKLEKTFKKKEEKEQKEQPRLKLIDVFQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9S8</accession>
    <name>A0A367K9S8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000160">
        <property type="protein sequence ID" value="RCH98926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9S8"/>
    <dbReference type="STRING" id="86630.A0A367K9S8"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="188"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="358" mass="40578" checksum="F5D4AD9CDF9EE68B" modified="2018-11-07" version="1">MSQENPLKSPETVPLTTEEPVRRTWLKDELENINRCSPEEETEQELELSHEQNKIENIIQPEENQSDGVDMMALLSRQLSDYEDKTEDGYQNVQEPDDKLSDEELIKRTEQNKCISHTPTPPLSNNSSNASLHKQSEKVLQELLMFSENPVAINNVDRITVIRYFGAGKSGILPSKYRLKRRQTKCYLVAFDFSDESDNALNWAMGSILRDGDEIHIATVSNREDNPDVVKASGLDKGSELERISKMLADRARRTMDQMLLFSIKVVTHAIVGRVKEKLKGLIEENKYDMVICGSRGRSSVKRLLMGSVSTYLVHATPVPVVVVRKKQEKPKLIRRPSGSHSLSESMRIGTLKVDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAK8</accession>
    <name>A0A367KAK8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_010366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000142">
        <property type="protein sequence ID" value="RCH99159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAK8"/>
    <dbReference type="STRING" id="86630.A0A367KAK8"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="355" mass="40341" checksum="4D6AF6A211E8FF8B" modified="2018-11-07" version="1">MNIMRINHLQQNRQLNVPFFHTSSKPQTEYTLTVRQQPKKARLCSFKDKVDRRPLDPPPIVQLHQTGSINFNNYWISSNFFVIATLIDSENYSDIHIVNGHQTTAGSIAQSLHKLRDTDNREGAFFVFSDISIRIEGVFRLKFTLFQIKGSEAERICYVISDKFQVYSPKCFPGMSGSTELTRLFSEQGVRLRIRKEARAACASPMKRRREIQQNQNVGQNLESNDTHKNTKLRRTYQSSNILSPQEGYSGTSSSEQKCTNVMSMQNLLITNSERSVNRASISSTSSSTASYKNNLLHQRILPPPLPTASYAYGFFSTSGAQDTTTCPQPIKHHQQILSTAIYSLHSQSYPEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBD3</accession>
    <name>A0A367KBD3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enhancer of rudimentary</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E(R) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000125">
        <property type="protein sequence ID" value="RCH99419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBD3"/>
    <dbReference type="STRING" id="86630.A0A367KBD3"/>
    <dbReference type="OrthoDB" id="7887808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY ERH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373:SF0">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13841" checksum="6BE5AEB40FF99D7D" modified="2018-11-07" version="1">MGNHTLLLIQPSQRPSSRNYHDFETESQAFDRIAEMYENQLAKENPNVGQIQYRAEDLFRFIDSHKEFVALVFDPRTSTYRPHDKDWIKDRLIAHFSRQQASAPPGQPRRNNRRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBR3</accession>
    <name>A0A367KBR3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000116">
        <property type="protein sequence ID" value="RCH99549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBR3"/>
    <dbReference type="STRING" id="86630.A0A367KBR3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="26061" checksum="4CAAF318397367B1" modified="2018-11-07" version="1">MSLYYRYPDYKFCPQKKVKKTRTYKRRPKDEFTAIDFESRRQLIEIYHRPVKSGEDNNSPFVKKEANRDANIVVWEAPNNEDKPKITYSSCSYSHLHPYSSTLGVSPSASPMSLTYSCAHSTMDGFCGSSDCGSPLSGKTLDHLDNRDRSSSPMELFLHNYSESDADHMMVVPGQAIAGDASFLSELMDMCSSHYGQFVDYTTLLYPRWTHITREQPSMVPTYFFTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBX9</accession>
    <name>A0A367KBX9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000102">
        <property type="protein sequence ID" value="RCH99753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBX9"/>
    <dbReference type="STRING" id="86630.A0A367KBX9"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000046">
        <property type="entry name" value="Related to CDC24-GTP/GDP exchange factor for Cdc42p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="172"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="372"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="727"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH99753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="92706" checksum="48C62B09977E0F88" modified="2018-11-07" version="1">MIDSPVAADSITNKQATQEASIYHTCRSVLNALGYVKGFEKYLEETDQEEEFTDTTMASDPLTKLWNVCKPGRSLCFLFNVLKPDTPIIVNPATPNQTKAHIYHFIIACRNQLHFPEESLFTVTELSQNDTNGFVKVVNTVKRILELLIEQGVIPKHALTEVETSNESPKDQRDNVVYELVSTERKYIQDLEALQNYMREVQAQEILSPDTMHFLFGNLNALVDFQRRFLVQVEAHAARPAKEQRFGHLFIQFEEGFTVYEPFCANFQIAQDLVIQEAHKLQKLANIMSPTYELPAMLIKPIQRVCKYPLLLQQLIKSTPDDWPYSEENKEGLEAIQRVTKKVNETKRIQENSLVVEDLKKKIVVEDGSECLLDKYGQLLLHDKLILQKADSDHVKEMVVFLFEKVILLCKEVKDTNKNSISIKKKRKEGTLIVRGKILMSRIEHVKVSSAQTGLYILHISWTEKDVGQTVLLKCRNDELLQQWLNAIVGIKESTSKIDILPNTPQTPLTELNPLQDYYDDDEDDYYNHNTNHPEQHDDHQPMDGSYPYLRNRSYSYQYNRMPHHLPHEHMARKQSLGNLSSSNNLPPRHFMNGIPGMTLPPLPRSPTHPSISNASTSSSSLSSSTTSTDMYVSHSLPYSPPTSHPSSPNNHTPSGALWQRRQQQQQQQQESKDETMYIRSRTSSNTRPRNNSINSSVELLSISSNISTTPSSKRNSNSSQEIPENYIKIKTHYNGSIYVVVVPLTIEFGELKKKIENKLRLCIQESAISVSVLKYEDEDGDLVTMNSTDDVQMGFETKGPNNVVNFHVTAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC30</accession>
    <name>A0A367KC30_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_005744</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000105">
        <property type="protein sequence ID" value="RCH99700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC30"/>
    <dbReference type="STRING" id="86630.A0A367KC30"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="635"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH99700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="719" mass="83043" checksum="6EC1FD8AAC55762D" modified="2018-11-07" version="1">MIDELKVGPHQRAHSVLAVPGEFGQQLKKKHKENKDESWYQAIYKRYGYEPKQKNNPSYFGPYLLLQTLGEGEFAKVKAGVHIETQQDVAIKLMRKEHIQHASLETKLEREISVLKTVHHPFIVSLYEVLEIKNYIGIVLQRAFGGELFDYILKHHYLQENEAKRLFAQLISGVHYMHQKHIVHRDLKLENLLLSKDRNILITDFGFANRFQIEHQDLMATSCGSPCYAAPELVINDDDNNHYVGTAVDIWSCGVILFAMLCGYLPFDDDPNNPQGANIHLLYKYIISTPLELPTSMSEDAKDLLRRMLVPDPRKRCQMNDILDHPWLQDYHDLLHKSMEELEQMASDTRFNLSVSPNTQTNISESREQDVQEHGAICVTNTDDVPSLIVEEKEEEEEEEESHPSTPEEQQKTTLFQSKFFSAISRHVSVKIPQFNNIPTRSQSVQARPRTISDIQPKPQAFDILPSVSEQTTIQKKSKGQKLKDWFKRKNTPSTKSTIERLGLPERPLSTINPIRAMPIGKPLGSYAADFNDSKLRIHRGAVDQDALTSKAPNEVLFTIKEALTFMGISMKRVHDFKIKCIRPSRQQQQLQQLQLQQQQQKRTSLKLFFHHNLHNNINNNNNRHKGETMYGEQGIDNGDQVQFTVELSKIENLPGLYVVDIRRIRGNIWAFKFLYHTLLDLLDLRNGGYMAHRRVSFDEKQNRISYLTTSTHSTNDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCA6</accession>
    <name>A0A367KCA6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000094">
        <property type="protein sequence ID" value="RCH99872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCA6"/>
    <dbReference type="STRING" id="86630.A0A367KCA6"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF72">
        <property type="entry name" value="CAMK PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH99872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="39515" checksum="6E8D298CE729824E" modified="2018-11-07" version="1">MNTAYNQPYHYNKAQPKPSSACLMNYPLHPDFLANYIIGEELGAGGYGFVVSARERKTGIERAVKFIYRHMVPSHSWVKDSTLGHIPMEVYILKNIRHPNIIGYVDSYQDHCFCYLVMELHGTQWTGSPNSSNFPRSPALSETSQSTCSSFLDSPIEEYLPEPPVIKRRTSCDLFECIEKHNYFQEPLAKMIFQQIASCVAYLDILGICHRDIKDENIVIDDQYQVKLIDFGAAVVLPRHYGDHTKYLMTQFHGTVSFASPEILMGRPYKAESAEIWSLGVLLYTILFGEIPFHDTKMAIAGRFAQPKVQVSPTCLNLISWMLQRSPEHRPTIHQVLMHPWFSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCT0</accession>
    <name>A0A367KCT0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000087">
        <property type="protein sequence ID" value="RCH99986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCT0"/>
    <dbReference type="STRING" id="86630.A0A367KCT0"/>
    <dbReference type="OrthoDB" id="2289963at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="467" mass="52402" checksum="5E988A7247FE6E8A" modified="2018-11-07" version="1">MNNTQEIDAVVSQELTIISKNLVRAASKTANERIISSSMKRKHAQKFELKEVQEDDGVLVDGMCQSVGTTIKKEALRLRPSYFQLEYDEKYLVDLGLNSILFLSRSRDAGQARLFSEESWRKLKEVYSQVLENHADPVSKYGEKLSKLEKLGKADLRDARAYAFKNEMKSTRSDQADLFAIYSHYLEVMEYHGYIFDKDIDITEADLTVKMWGSLFEKLFRRTKLRCKWGESVGDSSGAAGSPGFKVDLRVIKDTLSRRNKEADIGNMEMARMGASVVKTCSDKSKLLIESKCVLDCLAREHPEKACNIVVPALQIVGNKAVLFSLRLVAPGLYVAVKEAAASISSSISKLKDFRDVAKLLFKFKEATISVANIRLQGGDNSTSISTSISTSNNSNNSNNSNTTSWLRGTWIPPRGNMKKMVPDVPHVLVSGDLSLWFKEEKDVRARSDPIRSTEWKDHCILILSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCT1</accession>
    <name>A0A367KCT1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-homocysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SAH1</name>
        <name evidence="1" type="ORF">CU097_000514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000084">
        <property type="protein sequence ID" value="RCI00035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCT1"/>
    <dbReference type="STRING" id="86630.A0A367KCT1"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="7951" checksum="48841E57A1C40FC8" modified="2018-11-07" version="1" fragment="single">MPGLMEIARKYGPLQPLKGARIAGCLHMTIQTAVLIRTLIALGAQVTWSSCNIFSTQDHAAAAIAASGVPVYAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD85</accession>
    <name>A0A367KD85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CNOT7</name>
        <name evidence="18" type="ORF">CU097_000006</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000077">
        <property type="protein sequence ID" value="RCI00148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD85"/>
    <dbReference type="STRING" id="86630.A0A367KD85"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI00148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="33393" checksum="6D88F61EC03F4894" modified="2018-11-07" version="1">MPVNDVKYIKEVWAENLEEEMAYLRDLVEDYPYLAMDTEFPGVVARPIGSFKTSSDYHYQTLRCNVDLLKIIQLGVTFADQHGNLPGNVCTWQFNFKFSLTDDMYAQDSIELLTKSGIDFKKHEEYGIDVEHFGELLISSGFVLLDDVKWISFHSGYDFGYLLKILTCSVMPADESEFFDLLRTYFPCIYDIKYLMKSCKNLKGGLQDIADDLQVARIGPQHQAGSDSLLTCTTFFKMRQMFFEDKIDDQKYLGYLYGLKCSPTNNNNTTMKSLTTATQHLSIQNDKPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDR0</accession>
    <name>A0A367KDR0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000069">
        <property type="protein sequence ID" value="RCI00281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDR0"/>
    <dbReference type="OrthoDB" id="2292140at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016744166" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="72" mass="8227" checksum="683D17E71EDC464D" modified="2018-11-07" version="1">MNSKIFAVLFAAIFYFTTVSAMTCKCARGPTVITRQHTDYGTTTCYNMTKDNTTKYFIPQCKKDGGDRWVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEJ3</accession>
    <name>A0A367KEJ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000070">
        <property type="protein sequence ID" value="RCI00262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEJ3"/>
    <dbReference type="OrthoDB" id="2284791at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="25551" checksum="7C546A666E94BFE2" modified="2018-11-07" version="1">MNNVCLWLEKRDESEAIFYRRFASMVDTGVILTDGETSLQPLKVTIAMNKAIFHTSDMSQAYDRKIDMMKCSSSVKVIEKSNLFSFNTKFRMKFTVAMDFIGNFGYLELLRLVDLSLDDYIIVAHLVTDLVIPTTIETLCTVKDTLDHLVSIAWKVRSELYKLEHASVLDDIYPTPSTGSSHSKSPFIFFTPRNNHVQKRKLLKLNDDETNVNSFTDRLQSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KF50</accession>
    <name>A0A367KF50_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000039">
        <property type="protein sequence ID" value="RCI00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KF50"/>
    <dbReference type="STRING" id="86630.A0A367KF50"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712807" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="16196" checksum="3F0E6E9B48E42963" modified="2018-11-07" version="1">MKFLLLWLFTITFVFGIDFKNKQEHSNYGEQKHNKAHIQEHLNALTNNTDQPLPDLKDEDMVYYLFLIHDQNGDGFLDGHELRQAFTDFGHDEDVSKYLSLDEITEMVDHVLEEDDLNGDGLISWSEYLESQIYHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFN7</accession>
    <name>A0A367KFN7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000032">
        <property type="protein sequence ID" value="RCI00940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFN7"/>
    <dbReference type="STRING" id="86630.A0A367KFN7"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10436" checksum="0C8EF5B5DD6421AF" modified="2018-11-07" version="1">MFGQLLTTATLRFSSLTNAVRPTLMGQSMFSNPLSNVLTTQMRFVTRGNTYQPSQLVRKRRHGFLTRLATKNGRHIINRRRMKGRKFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFP5</accession>
    <name>A0A367KFP5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UFD4_2</name>
        <name evidence="9" type="ORF">CU097_014856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000028">
        <property type="protein sequence ID" value="RCI01036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367KFP5"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="903"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1591" mass="179001" checksum="EFD6E33C6D48C37C" modified="2018-11-07" version="1">MSNQQQQNLDETLQDSPYIPSLEYEEKEEEDHVDEESQYDNGHGEEENEDEDDEEVGDEGDEEEMMNELNRVRRALGLQMEGLFGGMPSDSNRFRSILSSLKNQEEPTMQLIALQELAEILSVSNEDNLIGYFSCDSFVKELIRIMSGPEIMADMDDDMMLALAMSEGLSAGNPEIMLLACRCISNLLDALPTAATSIVFHGGIKVLCQKLKSIQYIDLAEQALCALEKISAQVPRAVVHEGGLSASLMYFDFFSVHAQRTALRTASNCLRGIDQESFSQVTEVTPTLMNAMSYSDRTVVELTCLCWVRISESYRSQRESLERVISVDLLKTLFGLIPITGNSNAVRPATFQDILRIFRAVAKASPHLSFELLKMDIIGAFYHILTGSAAATNQPQISHVTLDSKWRESVPTIIKTMADLLPPLPKNSMFSSRRFKENGPVASRTRSSGLPLPSESGSSPVDPRISWFEEHSEFLVRIDSILFPLFLDMYASTVNLRVRQLIIHTMLRLTHYTNPEDLEKVLKNVPLSSFLSGILTRQEQPGLIIDALYHAELLIKKLPSIYHVLFEREGVLHEIESIAKQPIVSESQPTQNDANLDESDATTTDAEKKQEGDEEDESEQEERRDTAIGSSQERSSLPQRRILDRGDLQALLQEHYALLQSSRTGRHSQSAGESEKGLGRGSVRKYIIQLAQNFIANYFHTDEANADGVPSRAPGSTLKEIAIFTEQLMNLQDRESAEKTLVQLSAYLKNSPMGISSFELTNSGLMKAMLAFLTQKDGFNNISREERKHMFETIFMDRPDLDEDGNNSLKKLVVRLHEILSRSETFEVVSPLESSSSDSLRNPTSMLAKQLRLRLTGKGENIPSSYRQLMVSTHAVAMFRVLEEYLLARLRASSELEDHHDDEHEEDENDDDDDNDDDNDDDDDDDDDEEEEHMLISGNGDDDEEEGMDVDDEDEEMVDAVEVQKDNSEDEEAPEGKQSKPCASSSNNKKKDGEWRIRFSLNGTIISNDTTVYAAVHQYEMKEERSQTRSGRSIWSSSYPVTFERVWVPNSDSSDDTKKAAIACQLADVTKPKELSDDSVCVQVILLMKELSLAITKNSVGISAQDFINRKLTAKMNRQLEEPLIVASSCLPTWSYWLMSVAPFLFPFETRYLFIQSTSFGYSRLIARWQSLQMRNNTQNGPRDDGHQSQQPILGRMERQKVRIVRTQMLESAIKIFDLFGSSPGVLEIEYVGEEGTGLGPTLEFYASTSKEFSKHSIDMWRGSNKSLSGYVDAPNGLFPKPLAKPTSSSAKKVIQLFRTLGQFVAKAMLDFRIIDIRFSPAFFKVVLDNVKPSHELLMEIDPVLAKSLNLLQSFIDKKNTIYADQTKSHIQKMKEAENIEIDGVKIEDLYLDFTLPGDSKYELKPNGSEIPVTIKNVEQYVELVLDAVAGSGVAAQIEAFKEGFNGLFSIEDLKLLTHSELVALFGTSEDDWSLATLTDTIKADHGFTMESKSVQYLLEILSEMDAVQRREFLQFTTGSPRLPIGGWKALRPVFTVVRKVPESNLSPDDYLPSVMTCANYLKMPEYSSKEIMRQKLEKSMKEGQNSFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG44</accession>
    <name>A0A367KG44_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000023">
        <property type="protein sequence ID" value="RCI01147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG44"/>
    <dbReference type="STRING" id="86630.A0A367KG44"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="101"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="230"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="870" mass="100727" checksum="E0414E34161F00A0" modified="2018-11-07" version="1">MISSSEEASLVNGMNNVQLQDNNHEAPAFSGGHKDDDDDRPLSFQRAPSYPRPISVRNMAMKNTTRPANFIKPVPQFLQNNVPVPSDMASVQKLYENYSQKVYLEGYVYKKNDLTVDGRPLGENDWTKWYMELCGPVLTLWEDIEGDEIMPQFINITDSKVEIYSEKDNIFSLNSAGQNRFLFNAIEYEMLLKWICSIRLSCFECSKLQEIYTRRLITRSTFSDLLSKPQTKMEGYVQVRLSGTTEWQRYWLNISEKSKKLFNKSKEASISFYESKKSKSPLYAMTQVLQAYVIYPESPQLMEVSTIFKIEGIINNEYSTALVMASSTKELAQWIITIFDSFKIYGRPSQLLNDTTNVQSLNFGESPDSSLFLDLQDVFMHVDVINQKLLDNKAQFSDILLQKLNTRQQQQQQQQQQPMRQFGLIHQIPNQRASTPLLNFNQQLMQQPMQQPMQQPMQQPMQQPMQQPMQQPMQQQIRGNQSHAIYASDEGEEEEEEDEEESDSDDSVFAKKKQSTSKSQEIETTNNTKKETPLSSNTSLPLKETKKVEPFDTDEDSEEDESDADTKPKSQPKKPRPKATQTQISDSEEEEEDEQEEEEGYSDSDDDIPIHQSRQTLYYNQHHPQGEEYYDEMYDTQQYYSNGYPIMTEDGPVIPQLGDNFATQNSLLDTFRPDHPSARDQEGYARATGQPLIQVPNKPPEPRAGLVGMISQIEHEKKQKEANKSRLLDKEGILQRERERYLMEQRAQQQSMQQPQHSMMQPPMMGMMNQPMMNMPQMPMMTGQMPMMGLMGQPMMYPMMNMPMMPMMMDPHMSMMLMQQQYGQYNPMWSQSQMFANSRFTNSVHEDDDEDDDVPLGAKESSAPRQQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGR5</accession>
    <name>A0A367KGR5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KIF24_5</name>
        <name evidence="10" type="ORF">CU097_013913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000013">
        <property type="protein sequence ID" value="RCI01367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGR5"/>
    <dbReference type="STRING" id="86630.A0A367KGR5"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF20">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="158"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="635"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI01367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="793" mass="89319" checksum="7FFE467B74EB5901" modified="2018-11-07" version="1">MMTTSTSTMTSGLRQPQTYSNSSNSRLPQPDSISRTRRQSIIDKPTPPPSIMTANVGERHIRSRTMSDAPRPDLQQLRSPLKDRRLDLRKSLLLDQPDDQDSEEELETKNRKYRSSAPLLDAYGVPLSPAKAAASLRSSTAQQQNTAFNLPQSDLNQKIRVCVRKRPLNRKELEKGDKDVAPTLGTRSLQINEPKLRLDLTKYTEQHTFTFDDVFDSNVSNAVVYERTALPLVNYIFKGGKATCFAYGQTGSGKTYTMLDPRRGLYILAARDIFSMLNRPENQHLTAWIGLYEIYQGQLYDLLNNRKKLFAREDGKNNVIISGLKEYPIDNVDKLIQVFDYGNSVRTTGTTGANDTSSRSHAVLQILLKHKENRKKIHGKLSFIDLAGSERGADRGEADTKTRMEGAEINKSLLALKECIRALDKDKRHTPFRQSKLTQVLKDSFVGHSRTCMVATISPGGSNSEHTLNTLRYADRVKELKGEREKRTSAERNYNSVQEEEVYEDDDEEYIEDDLNDDEYFSNESDILDDDTFNEESLFDVDFPHEQDSLLQSSAANTFTPRSLTDSYTSLSLSQQSQTRSDSSDAYIKSSSQSKPHSMIYRSNTQYDNPSQQRPLSLQAKHQSLNLPRSYSMYSRNSTDTASDTSSTYSSPQRSLLSSNSNNMTATTTTMTTTTTTAAAAAATMTATPVGDGVPSFSNDRIEEFIKFHRGEIREITDCTKRETKLVAHMSLHLSSHQDDDNNSSSSSHSNHTKNTSEFLKYLQDLDEILEHKLAAIEALRDRISDTVGQIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH83</accession>
    <name>A0A367KH83_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_014280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000020">
        <property type="protein sequence ID" value="RCI01212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH83"/>
    <dbReference type="STRING" id="86630.A0A367KH83"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="34"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="12">
        <location>
            <begin position="520"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="13">
        <location>
            <begin position="658"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="11">
        <location>
            <begin position="796"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI01212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1277" mass="141982" checksum="408008385BD13CEC" modified="2018-11-07" version="1">MTPTPIQEYPVHGLMPKQDTQAASFIKKYPQYDGRGTVIAILDTGVDPGAAGMQVTTDGKPKIIDIVDCTGGGDVDTSKKVKPTVEDGVSTIEGLSGRKLILDNSWNNPSGEYRVGVKRAYELFPTELKNRVKSERRQNFVKKQAQLLSEAQYRLADYNKKTEKVDEAEKAELEARIEALKELDKNYEDPGPILDCVVFFDGKDWRAVIDLNESGDLRGQPCLTDYRKELQYHTFGKADLLNFSVNIYSNGDVLSIVTLSGSHGTHVAGITAANFPDEPALNGVAPGAQLISLRIGDARLGSMETGPGLTRAAAHLAMHKVDLANMSYGESSGLPTDGHFIQLLANEAIGKSGCIFVTSAGNDGPCYSSIGAPAGMDESFITVGAYVKHAQMQAEYALLESVNERPFTWSSRGPTTDGYHGVDIYAPGSAITSIPVYVLNKLDLKNGTSMSSPNACGCVALLVSALKAEKLEYTPYRLKNAIRQTAKSVNDPLNVGFIQVEKAWEYLENYKDRQDLDLLYRVTVQKRGVQRGIYLREIEETSNVQYINTKVQPKFMGEFDPENPKYNTAKFNYEARVALIATETWITVPDYLYMHSGGNAFQVKVDPTSLASNKIHYGEVLGYDTAAPDRGPLFRVPVTVIKPLVPKNGSIEFKNTEFEPGYIDRNYIHVPEGATNVELVIKSRAPVETSPARFMLHLLQLVPKQNQKGKHAFSVLLGDGSFGNPASEEQTISRRLSVRPNLTLELCLAQFWSALGKHTVDISLNFHGVQIAGNLANGQGTIRLEPQLTRLEICSPLRKEVGVNPSVSFDKLRKYIRPAEATITPMDAERDLLPTGRVLYQLVLRYNFTVDSSTSVIPRFPPVMNQLYEHFLAGVFGIVYDANRKIVGYLDVFDHKIKLEQKGEYTIMLQLSTEEENVLEKLKGTVCELDLDLKTVNFNTYTNIADVYKKDSSTATKTNLERKDLTVLYIAAPTGQDAFPKEVKPGDALVGKLDFVSKVEGGQYKAIYTVPPSPAESKSDKEKNEKPTEEEIEQQLKDAMRDLEISYLKKFEADSAAYKALLSKIESQYVDDIAFLEFKLSRLWSTSGNSEIESLTTPGKLSSSEAKEIIQVTDAILAKINERELSEFYGLKEPENETDEQKKKRKQNDQKKKQLVNALKHKAMAYAATLDDEANVEPFKATVMALQQWTSDDSSSNLTSLLLKVKQERKAGHPGNALKAVQKYLSEASFTSSSVKDISKVWKVRNELYKELGWNLWSEYDDKWSVIRQPPYGYALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMT1</accession>
    <name>A0A367IMT1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004804">
        <property type="protein sequence ID" value="RCH78943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMT1"/>
    <dbReference type="OrthoDB" id="2240619at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="10964" checksum="2B12205B8858AF0F" modified="2018-11-07" version="1">MFFAYFYKSGELMKLFGLKSIEILLLETLCCFDNKDKIKTNFDHHKGMLDCLVMLKSISDEFEYALIDRFKKMKAFFLNAASKQQIRSKEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INE1</accession>
    <name>A0A367INE1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004654">
        <property type="protein sequence ID" value="RCH79188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INE1"/>
    <dbReference type="STRING" id="86630.A0A367INE1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="218" mass="24305" checksum="15A20CC833791C3C" modified="2018-11-07" version="1" fragment="single">DFGVVSISPAADSSIEEAGVVLFWSPELVQQKIVNYKIDIWALGIVILEVLNGGKAPYEDEGLEEEEIKQRILQVQRPVYPPNLPSQLVDLLDHCLDPDPHTRYSANQILEHPFLSSYEPELLFPATPLQQGKKRKQAPSTPAKCRIPIRAFSVDKTLSASVPVQERILSVHLKRQSLSNANRSQGSRLPMLCVTPIIEEKVKKPKEKKPTSPASKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPE0</accession>
    <name>A0A367IPE0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase HAL4/sat4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SAT4_1</name>
        <name evidence="6" type="ORF">CU097_001025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004420">
        <property type="protein sequence ID" value="RCH79560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPE0"/>
    <dbReference type="STRING" id="86630.A0A367IPE0"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH79560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="32395" checksum="3FDE03BECDB5F636" modified="2018-11-07" version="1" fragment="single">KIIGTGATAKIRLLEPRYGGDKVVAMKIFKKKDKDETEKEYDKRMTSEFCISKTLYHQHVVQVFDLLKDRKGRWCSIMEYCSGGDLLSVIQQVDLNDNEIDCLFKQLLLGLNHIHSSGVAHRDIKPENLIMTNDGILKIGDFGVADVTQSCFDTEPRYCRGRCGSEPYWSPEIYISNEYDGKALDIWSCAIIWHIMLYRHIPFLKANEQDEKYIEFLESKRDWLPLSKCTELEKDVLFGMLDINPMTRWTIDQCLNSNWIQSIELCFNNNKKHNHHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPJ2</accession>
    <name>A0A367IPJ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MVP1_3</name>
        <name evidence="10" type="ORF">CU097_002237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004413">
        <property type="protein sequence ID" value="RCH79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPJ2"/>
    <dbReference type="STRING" id="86630.A0A367IPJ2"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH79573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="266" mass="31477" checksum="80253B9C351E7828" modified="2018-11-07" version="1" fragment="single">RYPFRLIPHLPPKRLTARSLEFEENRRRGLERFINAVVRHPVLGKDDIVHTFLSHTSSLTEWRQQQPPIALDDEFIEHKQNIEELEKMVPIDWDDRVIRMKKRSIQYIKQYQQMLFIMHRIVKFKKALGTDYIRYSMALTNLAEFDKDCTFSHCQGCPQLAKSQSSIAKSMQQAGMSLNREAVEMEDLVIEHLIRQKDLFVSFKELIERKESMPFVSNDILAQQMAKHKQLADHGLSLIKQREIFIKYCIMTELSYLHKMQTNVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPN8</accession>
    <name>A0A367IPN8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004362">
        <property type="protein sequence ID" value="RCH79664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPN8"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="117" mass="13979" checksum="2AD34C0F5E20328E" modified="2018-11-07" version="1" fragment="single">KWVWKWCDTCQKRFDAENHSTTCPICDAAFEYIFQIAFLLENSGLVLLAYAFNQYCKNLFPNYTPKEVYENEAKRRELEIMVNSLCNERQFRIGLKSYRNPREELSFAIVNTKFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR70</accession>
    <name>A0A367IR70_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004070">
        <property type="protein sequence ID" value="RCH80152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR70"/>
    <dbReference type="STRING" id="86630.A0A367IR70"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH80152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="32390" checksum="6315E4B71B91D350" modified="2018-11-07" version="1" fragment="single">MVMSNEISQEIKIICQNNIIKGSARAPDSHPWRSWKIKLVAVDHQRERRGKLSHLLDHVEYVLHPTFDNPIRSFSREPYLLQEKGWGEFDMRVILYFKNDWAEPENIFFDLHFREPSYAILHRITFYNPPMPLLGVLALEFAPSDSEPTTGTAKKRRTSPSLAKAKTLYDDTSDYKSVQDTSISTIVDDVLEEKDVDSIDPIHSAQLDEHTRRAWGVPEHIDMSKLAKRLMTLTSEQTEEVASILKNHILEENDEKFVVDLYSLGPDLITQLWDITEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IR87</accession>
    <name>A0A367IR87_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_000986</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01004050">
        <property type="protein sequence ID" value="RCH80185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IR87"/>
    <dbReference type="STRING" id="86630.A0A367IR87"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="14">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="15">
        <location>
            <begin position="190"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH80185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="457" mass="49789" checksum="21C049A790D58790" modified="2018-11-07" version="1">MASRLLANTLQANVGLTKQFVRPLATAAKQAGATRITNLPNGLTVATDENASSGAATVGVWIEAGSRHESAKANGTANFLEHVALQDQAAKFEKVGGVLNAQTGREQTYYAAKTLGANVKESVQILADLIQNTKIDSTTVDKHRSAVLKQQEDAQNDFEAVVFDHLHATAFQGESLGRPVEGIKETVEQLTADDLSAFYKQYYTADRMVLVGSGAVEHEALVRYAEENFKSLAASASNVATDKPAFTGSEIRLRDDVLPQARIALAVEGAPYLSEEYFHLLVMQAIIGSWDKNLNGAPFLSSKLSNITSENKLANAFASFTKGYKDTGLWGMYVETENRTQIDDFIHFLQKEWNRLSTSVTASEVERAKQQVKGSLLLSLDSTCAVAQDIGSQVLASGKHLSADELKAIINKISVNDIRKSAYKYIWDQEIAVVGHGPCEGLTDYNRVRGNMAYNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRK3</accession>
    <name>A0A367IRK3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003977">
        <property type="protein sequence ID" value="RCH80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRK3"/>
    <dbReference type="STRING" id="86630.A0A367IRK3"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="239" mass="26684" checksum="16A8B53F88C77ADD" modified="2018-11-07" version="1">MTISNLTLIFTPAIFQDLNHAQSSPGEWAKDCVLEDLILNYNDIFANKDLHNNSAITGDIEYGFSESNSNVDSNRYAIAITSPESPTEVDYALISNANENSYILSLDDEEDSFEEQHEKVMLVKEETKLPERKSSIAPEPSMSKPKERRYKTQFQEKGLRLDTSISNKQMITPSAKSATVPSYDWLKRDPENSPVPSTTKLKRSSTTGKKLSSKRKNYTLDPDAAAAFVQLKASSSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISI9</accession>
    <name>A0A367ISI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003830">
        <property type="protein sequence ID" value="RCH80596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISI9"/>
    <dbReference type="STRING" id="86630.A0A367ISI9"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH80596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="13035" checksum="4DA6519B14B3FE5C" modified="2018-11-07" version="1" fragment="single">MAKLAEQAERYDEMVTFTKDVAKMGVDLTIEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKGNHAQVEKIKAYRQKIESELQEVCNDILSVLNDNLIPHAQGGESKVFYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU11</accession>
    <name>A0A367IU11_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-like with PHD and RING finger domains 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UHRF2</name>
        <name evidence="7" type="ORF">CU097_000431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003544">
        <property type="protein sequence ID" value="RCH81184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU11"/>
    <dbReference type="STRING" id="86630.A0A367IU11"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF45">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="YDG" evidence="6">
        <location>
            <begin position="43"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="395" mass="45483" checksum="DBBF63CD5AE37F3D" modified="2018-11-07" version="1" fragment="single">CINTDVDLIIDKEKKVANVMSSLDNLIRIKENECNIAPHNHVGKIPGVYCGQTWNSLKLLTNWGVHRCMSFSTRIVGSYITGATSIMLYRSSSGLETFEDKGYEFIIAGRNITAKNERDMLKKMLIRQDRALALTCDAPLNEEAGGTAYNWRNSRPIRVVRARNAARPPNEFEPEQGFRYDGIYKVVKYWPTILPNPDRVVWKFMLRRDDDELAPWLSKAEEEYKKKGLRMIHEDEKENKKLVKYKIPARIQKMMTEDTKNQRLWEGVKKLEFYSEYEFLNHLFENVVTCCSGACPKPIKNPAVTPCGHVCCISCLKHTKTEACFVCRAPILRKDIKIDEDLVKILMALNPIYQAQTDKIPCPALGYGKAKRKRTTTTMKIKKPRKRLRIVIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUL5</accession>
    <name>A0A367IUL5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003467">
        <property type="protein sequence ID" value="RCH81368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUL5"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="134" mass="15249" checksum="515F82C5C40E1F4E" modified="2018-11-07" version="1">MLLIICYGNPELIDSNTGKMKTKNVIILPGLLNWLVFFPWILGGIGTVGAALVRELLAKNAPVTLFAKGSARPEKYKLYMDTGFFSHLDIYDLLTKRASYDARHPFIPDVIEILLGRKPETLEKFIFKNKHHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV22</accession>
    <name>A0A367IV22_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PDB1</name>
        <name evidence="7" type="ORF">CU097_000496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01003482">
        <property type="protein sequence ID" value="RCH81331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV22"/>
    <dbReference type="STRING" id="86630.A0A367IV22"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="274" mass="29384" checksum="34A9E766AAD4D118" modified="2018-11-07" version="1">MGFAGLAVGSAFSGLKPVCEFMTFNFAMQAIDQIVNSAAKTLYMSGGIVKCPIVFRGPNGAAAGVGAQHSQDFSAWYGSVPGLKVVSPWNSEDAKGLLKAAIRDPNPVVVLENELEYGISYPMSTEALSEDFVLPIGKAKIEREGKDITLVSHSRSVGFCMKAAELLAKDGISAEVINLRSIKPLDTETIFKSIKKTNHIVSVEQGWASFGVGSEICAQVMENEAFWHLDAPMTRVTGADVPTPYAANLEGLAFPDEHVIVKAVRDNLDKKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWR4</accession>
    <name>A0A367IWR4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003141">
        <property type="protein sequence ID" value="RCH82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWR4"/>
    <dbReference type="STRING" id="86630.A0A367IWR4"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="98"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="52"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="429" mass="50463" checksum="3149B27125ABDEC2" modified="2018-11-07" version="1">MRMEKDIIKDDLIEPQISATHSQEITNCVCHSVLSTTDSDRCRSCNQLICIIDNQKQECLTITLKVEKLKSQLKEKQSLNESIKQQLQDLQTAHDKRQQDIKIMIEKIDSIEQDIQAVRLKHQVEVAHTKAIEQSKKIVQIELQDLTQKLFEEANVLVSKEQQEKEQLQKQYDDLERMLAETERQLKLIQTELEQLREKMTHDEEIKTAAINRRSFGIKTTHENYVLRSQLDMSVLFGQRQPIEVRSILQDQLVLDEFAEFIASIRTVPMTKLSNLSFMKACLKSDIKPCLQMVKRISIKRVIDAIISKTCLIEPCSVPEKSNNASISTNGTLWDRLSQKKVDSSFVGCHLCGRTPEEEQERLLLRWKFRLSYFDEWTLMDRHCRDRLVSVMEFYDFIRRIKHGYYDNHPILDIYQECSRLRLRMFISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWW0</accession>
    <name>A0A367IWW0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_001344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003120">
        <property type="protein sequence ID" value="RCH82168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWW0"/>
    <dbReference type="STRING" id="86630.A0A367IWW0"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="103"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH82168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="275" mass="30232" checksum="A20B3A81860251DF" modified="2018-11-07" version="1" fragment="single">MSQQIPINITNLHPEQRPTYLSNSFRSFVSSYSRASMMHMAENVVLSDGGLSDDEEDGLSIYSSRPHSITTAQEAHEQSPLLHKTSTNHSIMTVADSYHTSPKKSTFMQSVFNSINILLGVGILALPLGFKSAGWVIGLGIFVFCFCLTNYTAKVLIKCLDLNPEAKTYGDIGAYTFGMRGRVFISILFLTELITCSIALVVLLTDGIASLFPGYDLVWLRLVSFIILTPTLILPVRYLSYTSLLGILSVFSLLLVILYDGFTKVDAPGSLREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX11</accession>
    <name>A0A367IX11_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003095">
        <property type="protein sequence ID" value="RCH82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX11"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="84" mass="9768" checksum="418F58AEE897DEF4" modified="2018-11-07" version="1" fragment="single">MSSRRILTQAFLRHHRILLQRPVARPAIVINKSCLIPTTGLFKAQCYSTDRVYKVLDFNDIQKLIKEGHQQCVAKNEQDYVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXB6</accession>
    <name>A0A367IXB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003058">
        <property type="protein sequence ID" value="RCH82324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXB6"/>
    <dbReference type="STRING" id="86630.A0A367IXB6"/>
    <dbReference type="OrthoDB" id="5600582at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="46060" checksum="B4B606BEDCE0BD3E" modified="2018-11-07" version="1">MDRYSRGYDDRYRGYYDRSRSDAYRPNENYRSERDYRDPGGRGHSPSPHYPSSRSPGRDSYPKDHRYSYSESRGYPGRYSSSNSPPSRSSSRSPRRPSYGYYHPSSSYSYSSRRSPSPIGMGSRSGSMRRDSYDHRPYQGSPPYSYSSYRYPPYHSRRHYSGPPPSYPPPPPPGYRPSYHSREPSSSSIAGPPPRSSHTTPSSAAPNSPKGIVTTPSISTPADNPIASAASSSLPSTHVTAAKSSTTTTTTVTSTHSIPSTSSRYSPPPAHPYASGSSPYPPNPAPRHHSTPYHYQHSSHYSGYSSGHPSPSGPPKQRISWAPEQEKELERYHIEQEKLHDEENKILAAVRKSRFELEFASWDASKLEHQLELVQKQWEENGMEELINNELTAKLSGKPTPMATRPQLPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXG7</accession>
    <name>A0A367IXG7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003042">
        <property type="protein sequence ID" value="RCH82357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXG7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="10657" checksum="E7672BC7A21E5C44" modified="2018-11-07" version="1">MLTYQRSLLINCAIEAIDEAVTETVIFNTEKQVEILQKATPKVLTNEDEVDDYDKIDAIGHSTSLMFLVRSFGVKLYKKGWKNLNAIERFMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYP7</accession>
    <name>A0A367IYP7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002885">
        <property type="protein sequence ID" value="RCH82808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYP7"/>
    <dbReference type="STRING" id="86630.A0A367IYP7"/>
    <dbReference type="OrthoDB" id="2328895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041646">
        <property type="entry name" value="VC0807_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="289" mass="32151" checksum="5336F86472C34EA1" modified="2018-11-07" version="1">MSEHRSAAETQNITDLSSLQDIFTFQFVQGRPITNIIMAILWSIGLPILLYELLKPRLGQVVAMIIASCPPLVIVISRMLKTRKLDVLGFVAGVSFLISGIISISQPSPQVSSICESIVPLLVGVFCLISLLPIKIGKFELRPLVFEVTSQLMPRTERNEELLAKDKQRLHNPRDAKNKGGLLDWVYGHMAKIRNDLRILTACWGIVLVVGFIVKAIVASTSTDISKAQHFGYIFFTLATLGMMAVSFMFTKLMKRHVKEESEQMVREGCSNVQWGIEAMSIGFNQVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0G8</accession>
    <name>A0A367J0G8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_006030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002665">
        <property type="protein sequence ID" value="RCH83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0G8"/>
    <dbReference type="STRING" id="86630.A0A367J0G8"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016484557" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="19"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="309" mass="35719" checksum="AB3B2F9E714FF69F" modified="2018-11-07" version="1">MKAQLLLILSCLIVLCLASSGDIQPEYNLCVDTCSSRPHLLPAYLRLFGWTVRDDCRYRCMQSITQEAIEQGARIHQYHGKWPFYRLYGIQEPASVLFSILNGLQHYKYFFRLKQQLSNTYYLKPIYMGISICGMNAWIWSTVFHSRDTPWTEKLDYFSAGLYILYGLFVAVLRIFHIRHRLAIAVWACLCAGAFAAHVTYLTRLPRFDYGYNMLACLIIGGIQTSLWLIWSIWNVKKRSYAWMAGVSVVLVSLAMCLEIFDFPPWLGTLDAHSLWHAATIPLAPLFYRFLLRDAYAETNQTSVDKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0X1</accession>
    <name>A0A367J0X1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002613">
        <property type="protein sequence ID" value="RCH83592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0X1"/>
    <dbReference type="STRING" id="86630.A0A367J0X1"/>
    <dbReference type="OrthoDB" id="5592473at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="56" mass="6626" checksum="2335C2981C5C2C64" modified="2018-11-07" version="1" fragment="single">MVWEYSMRHTSISVMDTEDGWMDGRGPKKHMKRLAAPKHWMLDKLLGKLKIVNEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J229</accession>
    <name>A0A367J229_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002491">
        <property type="protein sequence ID" value="RCH83993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J229"/>
    <dbReference type="STRING" id="86630.A0A367J229"/>
    <dbReference type="OrthoDB" id="2279974at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="19209" checksum="49C9F67844EE575B" modified="2018-11-07" version="1">MQTLSCQNFDKAQVHLQRDNDLKHKSKLNQQYRKLYTSDYTFRKVFERFLSAAAAATQLGIHVRTAQKWAKQYEKDPDSIFEKRRKTGRPRILHDEHKKAILECIDENPSIVLDEVMKKLKQMFTELKVSKTTLFDFVKQHCNLSLKKARLQPKDRNSEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2B5</accession>
    <name>A0A367J2B5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002496">
        <property type="protein sequence ID" value="RCH83979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2B5"/>
    <dbReference type="STRING" id="86630.A0A367J2B5"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="235" mass="27035" checksum="250B534AE5B31444" modified="2018-11-07" version="1">MTVVKEYYRILEISNNADEQEIKRAYKKLALKYHPDKNPSTEAEEKFKDISEAYEVLSDPQKRYIYDNRQNNINDDRDNAYSLDDLFGGFTFHRPEEVFAHFFGGMGTPFFDDFHHFGPPMHDPFHSMMSPFSYPSPFDMMYNMRAPSPFMHPGSSSMRSSIFDTHSQMGQGGYSKSVTTTTRNVNGRIETVTITKITDENGTRVTEEYGNGAHQQDRITSGTNLSSLSGQEQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3M3</accession>
    <name>A0A367J3M3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_002950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002335">
        <property type="protein sequence ID" value="RCH84554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3M3"/>
    <dbReference type="STRING" id="86630.A0A367J3M3"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="4">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="382"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH84554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="79296" checksum="7ACF63844BDF9837" modified="2018-11-07" version="1">MPQEHPFQTSFWSPTATIDNYPNFRYGFDILHKKLAQSVTENEAIANYIQERIEAERHHGTQLSKLPHPELDELTTLSRCFQVVWAESEASATEHWTRAENLHTTALDPLKRLASRYSRIVSNAKQTLEQQMSQFETLVKQLEQAKSVYHAKCRSLLTIQPNYRPTVIQLGTLLFYERFQVEDWMRPLNETGLTRREIVHWLQSEHQSPSVMHDLIGLHFLRQTGQDQYEKVVRQPVSKGLYGFFKWQQQQQQQQQQQPMEPYVRDMLQADKAYRELVTKVDKMRMQTEEALFMHYEEMESLELERIQTIKQVFISVAASLSNTIPRYKETVDNMMLYQETLKPDKDVQVIVEQHRTGQFCPRPVLYENYFYGAAHHQLFGVALDEVTRTEGTLIPNFMSKGMSVIESGKHETNVRPYTDILHIHKYNKLGLANLEAEEKHLVWITSLPLDRVHAARDQINQQYPVISQELLESYDVLLIASLIRLYLMELPECLLTFELYEPCKIIYSNQQDTETRLVSVSKLLTTLPTPNYHMCKVLFSHLNKLCDDQTLSRRFAHSFGYVLLRPQVESKVSTFERHPYRLIQDLIEHYDSIFTTESIKAQEENSSRTSIVVSKTSLDSLDSSRRRIRGHLIPSSSTLFEDPDELTSESTMNSTPPNYVGKEDTLELASLDSFFLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J414</accession>
    <name>A0A367J414_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="15">2.3.1.23</ecNumber>
            <ecNumber evidence="16">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CU097_005858</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01002328">
        <property type="protein sequence ID" value="RCH84579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J414"/>
    <dbReference type="STRING" id="86630.A0A367J414"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH84579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="506" mass="57888" checksum="7B7498693682F490" modified="2018-11-07" version="1">MNIITALLSRVIGLPEPTLRLLSTILLAYPSAFYYKKLYLSQDSLKSTREDRNQYILFAGLALSFFFNGFHIYHSLVTTAVSYGLCFILGEQMNDRKLALMTVWGFNALYLLVGYYYMQTDDYDITWTMSQCILCLRMMGFGFDYYDGRKKFTVAGAPTEKQADKNEDHTQAAIRSTEKAKPPVVLPLSFRADTPLTDLPDLKEVFAYAHFPAAFLVGPQFSFSLYRKWLNDDERQLNAEEHEEKERAQVAYIIRCVLLAAVYLGLQQTIGARYNTSYLLTDEYRSLCLLKRAFVFIVAGKFAYNKYIGIWLLTEGAIAAFGISYEGFDMAGLAQFRGLANTLPGTFETATSIDHIIGSFNINTNLWSKYYVFKRLKFLGSKLASQFGTLAFLAIWHGFHWMYFLTFLLEFLFVLCESILRRRLLPHVQPYTKQNEIYFYLWKLVAWATCQATCAYGIVGFELLKVGRAWTAYKSVGFIGHIAIVAIITADKYLPKNLGAPKMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4F1</accession>
    <name>A0A367J4F1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002262">
        <property type="protein sequence ID" value="RCH84808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4F1"/>
    <dbReference type="OrthoDB" id="2210431at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="19325" checksum="09868C1DDB8196B6" modified="2018-11-07" version="1">MSFLLEKLHVLPVRKLKFSTKVYYDQNDETLVRNLKKKFGLDAILVLGNWSAPNAKFHEPTRNKGLIRMLKKNGLTVHLIDEFKTFSKCSNCEDDLETFKTVINPHPYRRVDMLTVKCHGLLRYMIVVIVTIEFVMTITTELLGVKTPNVLPINLEENYGTETLPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J517</accession>
    <name>A0A367J517_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorbin and SH3 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SORBS2</name>
        <name evidence="5" type="ORF">CU097_004265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002210">
        <property type="protein sequence ID" value="RCH84996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J517"/>
    <dbReference type="STRING" id="86630.A0A367J517"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH84996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="294" mass="32961" checksum="01219E7B539E14F0" modified="2018-11-07" version="1">MGEESNIQAANYILESIIRDLGFLKDNHFLPHQTYQEVIALLPNHISAVDDTVPRPPLPLRKSNSNTTTHQLTPPQPRDVSSGPKLPVRRTNDWSPQPIAMPLPVVNARQPEPEKVHTTPPPPAYAEQNNSNVIATAEALYDYHGDDPTTDLSFKQGDIIEVIEYVNDDWWKGTTHGKTGIFPQNHVKKLPPPVKAKRPWTPQPPAKPSNDHLYNNNALANNNYNNNVPSYPATPGAPYAYPPPSTTIYQPQSYGPPVVAVAHEEEKEKCCHLGLWCRTWQQGRRCNLLMAFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5C7</accession>
    <name>A0A367J5C7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TPS2_2</name>
        <name evidence="4" type="ORF">CU097_004049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002172">
        <property type="protein sequence ID" value="RCH85147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5C7"/>
    <dbReference type="STRING" id="86630.A0A367J5C7"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH85147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="268" mass="30038" checksum="219B1A5BE56D97C2" modified="2018-11-07" version="1">MNKYTKPLNTTSLVNTYKAARKRLFLFDYDGTLTPIVNNPADAQPTSALLHCLQLLCKDPANTTWVISGRDQLFLDTYLGSKIPRLGLSAEHGSFMKKADIYDWTDMLKDADMSWKEKALAIFEKYTQSNPGTVIEQKKSSITWHYRNASDIQKATQQSQLCFDELKSIVGVDILIGKMNVEARSILVNKGEVVKRIKENEDYDFIFCAGDDQTDEDMFKALEGDQQAFCVSVGPLTKKTKAKYSVESSEDIVGTLGQLVSFSKNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J641</accession>
    <name>A0A367J641_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002103">
        <property type="protein sequence ID" value="RCH85417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J641"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="231" mass="26480" checksum="BD1E21FA4F25CBA7" modified="2018-11-07" version="1">MRPDTLPPDFYAFMIQAARCPKEALMLNNLNVRGISVSPKLALDSIQHLHPTSHAIKVISQLDPNPAAIPCYLPVYGTLHFVPMLLLRTQHLRKDPTGMLSKTTKATLKSGAFLATFVTVYQYQICMHRQLLKTGLIGRWNSKYLYGLAGFICSYLSIFIEDKKRRSELALYVLPKAVHSLYQIAYSHHWIFKMKYFEVLMASTAMGIIMEEPDVLSSFVRKIMFQFFQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J681</accession>
    <name>A0A367J681_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KIN1_4</name>
        <name evidence="15" type="ORF">CU097_005470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002091">
        <property type="protein sequence ID" value="RCH85464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J681"/>
    <dbReference type="STRING" id="86630.A0A367J681"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="428"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH85464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="716" mass="82692" checksum="EE6EA42A6E10F183" modified="2018-11-07" version="1">MSISTEETIVNESQDIKRSLSRRQSERHQVMKVQNYVIYRKTIGAGSMGKVKLAECLTDPTKQKYAVKIMPKIDLQTIKSTSHTDPKDTPQEREQRTIREMAIMRLLRHPHICQLKEYITEGDKYYMFLEYVDGGQLLDYIIKHGKLKEKQARKFARQIVSALDYCHRNSIVHRDLKIENILITKSEQIKIIDFGLSNVYHPTQQLNTFCGSLYFAAPELLKAKEYTGPEVDIWSFGVVLYVLVCGKVPFDDTNLPALHEKIKSGIVDDYPDHLGKDCLDLLTKIFVVNPRQRITLSAIRSHPWMNKGYDEPINNYLPHRQPLETIDMTVVEGMQGFGLGTPDEIRSKLEMIISSSEYQSAATKIDENYQRKVTEDQVFASRPRWRRRLSSSSRIKHQAKDDFRTLPAMYDPLVSVYYLVKERKEAEERKRQLLDAPQTSLTRSTSTHETKPSSSSSPALARRQTIGAMKRSTSTSTVRQKSEASKKISSQTIDTPTTPAEIKPQQKPHWLKLEFNQKSYTSKQQSRTSFTSTASTIRRPSWKRLSFNHKSGSNDNSSPDVSPPPSKTLSPSSSFREPALTNSKSESTKSLFDFLSRGHFYRLTQAEIKARLLDILDQLSIDVTRCTDHALDCVFEYPVWSRFVYRETQENSERSKQIRMPLRFTILVYSARWSSHKTGFRIQKDDEQMSVTSFYTKEVFKNLYRTLVDRMDKLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7W5</accession>
    <name>A0A367J7W5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001965">
        <property type="protein sequence ID" value="RCH85995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7W5"/>
    <dbReference type="OrthoDB" id="10272545at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="157" mass="18073" checksum="F57696E447E56201" modified="2018-11-07" version="1">MRKFVWENKVNNRGEGFWGDCNEVLETFLNDLSPSARSFCDIGLFYAFKLCSRNQSHFGYISNNMPYLHYSYSLMQALHKSKESQCMDCTRELGEDSAEVPGITTRHNLIETEKPPLFLSDLTNIAPTAIKKIPQQFLYVVEIAETKYILHGKVYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J810</accession>
    <name>A0A367J810_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DYNLL1</name>
        <name evidence="10" type="ORF">CU097_010141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001946">
        <property type="protein sequence ID" value="RCH86077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J810"/>
    <dbReference type="STRING" id="86630.A0A367J810"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH86077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10401" checksum="68B8A68848C1A279" modified="2018-11-07" version="1">MSDAKAVIKSVDMSEEMQQEAIECATQALEKYNIEKDIAAHIKREFDRKYGLTWHCIAGRNFGSFVTHESKHFIYFYHGQIAILLFKSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8X1</accession>
    <name>A0A367J8X1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001881">
        <property type="protein sequence ID" value="RCH86377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8X1"/>
    <dbReference type="STRING" id="86630.A0A367J8X1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH86377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="762" mass="85533" checksum="39BAE9B7A71FCE41" modified="2018-11-07" version="1">MSVIVTRSCDIIRHDANHEAIVDIKRKKIPRLGPFLLLKTLGVGEFGKVKMGKHIETDQKVAVKLVRKDHIDSSSQLEKIRMEIEILRTLNHPYIVKLLTVNETDACIGIVLEYAEGGELFEYIYRQKYLQEAEACRLFAQLISSIYYMHEKNIVHRDLKLENILLDAQGNLIVTDFGFANQFSPITGDLMSTSCGSPCYAAPELVMTGNLYSGRATDIWSSGVILYAMLCGYLPFDDDIKNPNDNVGRLYRYIMVNKPKYPHRLSDDAKDIIGKMLVPDPSKRSKIEEIMAHPWLYEYADLFSKSIEELEMEAQLVKQILLRHTLSPEPSHGNSEYCSSCCESRVSDISSSSSSLASSSYSYKAKNEIGIGTIQEPTEKVNIEDPIKDDLQEEEQLSQQQKDQVIDSSDDGHVISQTSSKKESEPIEIVEEYQIKQEDEIEDEIIPIAPIRHDNNSVHAIQVLPTNDQTGVTTPYVESENLNVQKQSPLNKTSNTNVKSSVQVEQTNNKPNPGNTSLRAKFFSSVRIRPQKQSKTTKQDKKNDVNKEKTIKPKNKRNSWQALMHHDHSIEVPAPTPQQTKSTGFISWLKNKAHHKNKHCDTSRDVSSSLIPNYSGSFSSKSVTPSTFTDLRVYTGALNQSALTSKSPMEALLEITKILVILGIDVENDGGYKLMCTRRASSSAAIYGHSEIDSGEQVQFVIEICSLKDVFGLFCIDIQPLNSDNVYQFIGQKLLDLLHLGGTMKGAGYHEAILQYNASNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J963</accession>
    <name>A0A367J963_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NOB1_2</name>
        <name evidence="12" type="ORF">CU097_005411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001867">
        <property type="protein sequence ID" value="RCH86435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J963"/>
    <dbReference type="STRING" id="86630.A0A367J963"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="308"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH86435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="50998" checksum="3711ACC43B68E5FF" modified="2018-11-07" version="1">MSESTIATTSSHKETLKCLVVDTNAIINGTTLGNLAEEYYTCPEVLNEVRSAHSREFLTRLPFELKLLNPSEESMKAVIEFSKKTGDYGVLSVPDLKVLALTYTLEKRENGDANIRKEPLVTRPTGTLPSAPPPRSYIKNPAPAKVVDEDGWEVSIPKKKSKKKYNVGQITKTVQQLNINDKETVKQDEAMAKKEETKKEETKTEEKVEDESKKAREETTEVKQESDHAEQPELSADIPLTEEEDEDDGEWITPENVDQYKAAEIGVTPEELKQAETMKVGCMTADFAMQNVLLQMNLNLVSPGGYRVKKIRNSVMRCHACFTVTSDMEKKFCPKCGNATLQRVTCSTNSKGEIQYHLKKNYQYNLRGTKYDIPRPKGGRKVNNIVLREDQREYVKANQFKKKKALVDMFDPDFIPLYGKTNTREVTNNMFGTDVIGFGRRNPNAYKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9G5</accession>
    <name>A0A367J9G5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CU097_002987</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="PJQL01001838">
        <property type="protein sequence ID" value="RCH86578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9G5"/>
    <dbReference type="STRING" id="86630.A0A367J9G5"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016569936" description="chitin deacetylase" evidence="22">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="23">
        <location>
            <begin position="156"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCH86578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="419" mass="46040" checksum="8C9D312292C3F41B" modified="2018-11-07" version="1">MQLKSIAISVALAKLATIVSADASNYWQSFTSQVNPQNISIPSITQTTSVDPTAECQYYQPDSSLFVFNQSEWPTSWQTATSNGMSQSAEFQALYNSIDWTKAPNIQPRKLTASGGLDMSNYSATEDPDCWWSASTCTKPKLPDVNEDISNCPEPETWGLTYDDGPNCSHNAFYNYLQDNKLKATMFYIGSNVIDWPYGAMRGLKDGHHIAAHTWSHNYTTTLTNEEVLAELYYTQKAIKLATGVTPRYWRPPYGDIDDRVRWIATQLNLTAVIWNLDTDDWAAGLTTTEEAVEQNYQDFITMGTNGTFANSGNIVLTHEINNNTMQLAVDYLPKIVSAYKQVLDVATCYNITYPYFENIQWTNTLNGTSASNNSASSSGSTASSSTSSKIGSAAASSSGSSIVPSLGLAAVLMFTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA92</accession>
    <name>A0A367JA92_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glycoside hydrolase 2 (Mannanase, beta-galactosidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BMS1</name>
        <name evidence="14" type="ORF">CU097_002317</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001777">
        <property type="protein sequence ID" value="RCH86872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA92"/>
    <dbReference type="STRING" id="86630.A0A367JA92"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="74"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1098"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="700"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="436"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH86872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1146" mass="131958" checksum="4F5D18D4D1484D21" modified="2018-11-07" version="1">MEDQTHKTHHKQKAGKKVERKKENKFANAKKSSNPKAFTFQSAGRAEKTARRNFDLGEKKLHVPLVDRTPIEAPPVVIAVVGPPGTGKSTLIRSLVKRYTKHNLNEIKGPITVVSGKKRRLTFVECNNDLNSMIDIAKVVDLVLLMIDASFGFEMETFEFLNILQSHGFPKVMGILTHLDKFRSNKALKATKKRLKDRFWTEIYQGAKLFYLSGIINGRYPNMEIQNLSRFISVMKFRPLVWRNTHPYVIADRIEDLTDPELVHRKPTCDRTVTLYGYLRGTNLKSGMRVHIPGAGDHTLADVSVLPDPCPLPDKERKRLDEKHKLIYAPMSDVGGVMYDKDAVYINVPGHFTKKSAYAPSEKQQDGEEGEEEVVPKGTGEKLVMSLQDAQDTLSAQLQESELRIFSGSAPVKASDIKESLEEDESGRTRRRAVFGDEDEINDEEGDEDDEDEDDEEDDDEDMDEDDMMSEDEDHIPRRGKALTKFDTRNIPKKGDEDNDAKDEPAFEFADSDSDLGDEDEDNEDMVLVDGRIRRDTSDDEDLSGELRWKANLKEKASAMHKGNRRTNLMSLIYNNLDLSPEDILAGNYDNEKDDDIEEDDDEENFFKLKRETAENGAQAIDSSRDPIDLEELEEWDDEETLDSIRNRFITGDIDAVNEESAFPPEEDEEEFGDFEDLENDDSNENDKEDMIRDPVAVEREKIAKRKEQLRKKFEEEYDDSEDGPKMDFYEQKKQEIEQQLQTNRAEFENDDPVTRAMVEGYRPGSYVRILIKDMPCEFVQNFDPTYPIVVGGLLTSENQFGWVQVRIKRHRWYPKTLKTNDPLIFSVGWRRFQTIPIYSLNDGTRNRMLKYTPEHMHCLATFYGPVHTPNTGFCAVQNVSDNKASAFRISATGVVVDISQSTEIVKKLKLTGYPAKVYRNTAFVKDMFTSALEVAKFEGANIRTVSGIRGQVKKALSSPEGQFRATFEDKILMSDIVFLRAWYPVKPRKFYNPVTSLLLSSKDSWQGMRPTGQVRKELSLHAPQNADSIYKPIERKERRFNPLKIPKTLQAELPFANKPKQQTKAKKKSYLSKRAVVLEPEEKKVYTLMQQLNTLRNEKTRKRKLKDNERRENLEKKKAKLEKANELKEKERRKEYFRKEQQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAW9</accession>
    <name>A0A367JAW9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CYR1_1</name>
        <name evidence="17" type="ORF">CU097_002398</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001730">
        <property type="protein sequence ID" value="RCH87094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JAW9"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="130"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="883"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1204"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="620"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH87094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1570" mass="177626" checksum="BBDDF330A66CF515" modified="2018-11-07" version="1">MPLPKSTKQLDRSKNDNNTASKEKKRHLFRFGRKKSRSEILVPNEKKEDGMSISNQNMGTMEGIVNSEYQTYERAPTLYQIADPSSEHWAPPDSWAVQPPDEEDAHSINMQTTTDYFSVVEHETWNVQSKNYCIRVFRPDGTFGTLIAPLDATANDLIQKLAGKFFLQDWNRYRLTLVRHSLERVLQPNERPLQIQKLLLEQMGYMEEDRIEDVGREDNSYLYRFIFGISNSNNVQEEEDTGLYSRTDLHGRNLLNIPTFLYKYAARIASLDLSKNIHIEIPVDFLQLCKNLKQFWLNDNEYKLLPQSVRYIPNLEHLNISGNQIEDLQHARLDELSALKTLRAYNNRLNSLPDGFAKFQCLTILYISNNSFTKFPDVICELRSLVHLDISFNKITSFPEQIGNLTQLTYLFATANRLSGSLPQGFSKLENLQELDIRQNQITDIEILHDLPKLERISIDYNAVTVFDYGFKHLKRLRMSKNQLTQFSIKSHAWMLVELSLANCKLSSLADHLFLNTTNLECLILDGNTLTVIPSSIGVLTKLQRLSIQNNNLEVLPPEISKLKELKILDAQNNNLKTLPREIWLCTSLQTLNCSSNLLETFPEPFPMMSNVSMPSVSVAPTSQAGQGIAPPTPVSEQLPAHPFDNSSSDNSIPNTLLSNGFQPPPNFNPPSFFASPRNHPPPLSLSLRYLFLGDNRFTDDVWSPLSLFLELRTLNLSFNDLYEIPPDGLCHQHLYELYLSGNHLASLPADDIEKLSYLRVLAVNGNKLQTLPAEIGKLRKLLVLDVGNNVLKYNISNWPYDWNWNWNLGLKYLNLSGNKRLEIKKTHPELHNPNDRNLSDFNALVKLRMLGLMDVTILGVMTPEEDCNRRVRTSPSEVNSMGYGVADWLGPSDNLTTWDLVMPRFRNRDDECLFGLFDGLKHSKTGCRLTYFLNDHINQFFTNELQKTKNSDTIVSALRRTFLALEKEYGSLVAEDKEIGASGLVCYIVGTKLYVANVGDSLAVLSRNNGQAHEITQKHIPLNPSEISRIRAAGGYVSNSGLLNDELHVSRSFGYYHFIPVVNANPFVSTIDLEENDEFVIMASRGLWDKMNYQTAVDIARTEKDDLMIAAQKLRDFALTYGADSNIMVMIIGVGDLFNKRNKRRNYRGGPSRTGTSEVLIDEGIGTPSIMAKNKRRIKDEIPSDSTLARLDKEVPPPTNQVTLVFTDIKGSTQLWDTQPENMRSAIKIHDAVMRRTLRSIGGYEVKTEGDAFMVCFQDPVAALLWCFTVQLQLLEADWPTGILETEEGREIQKDNKVIYRGLSVRMGIHLGTPVYERNPITKRMDYFGPVVNKASRICNAADGGQICVSSDVIAALREMPGVFKDDKTGLSADRASARLHPLSRDVQQLKRLGFHIVELGEHRLKGLETPEMLSLIFPKQLAGRMEMDKSDTATLISTTTVTPQAEVNESPFRRASSALSLARPINRQIDPNLVASLNNLTVRLECLTAGRMEEVASDEEIIFLIENAITRIENAVSTLYLQKVGKFANVLEKLGEAIELDSSHILRALQIYSEVEGLLEKPTGLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBD9</accession>
    <name>A0A367JBD9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RPA2</name>
        <name evidence="21" type="ORF">CU097_008153</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01001697">
        <property type="protein sequence ID" value="RCH87250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBD9"/>
    <dbReference type="STRING" id="86630.A0A367JBD9"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="29"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="198"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="472"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="578"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="684"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1049"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH87250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1150" mass="129886" checksum="9860ACBFFDB900C2" modified="2018-11-07" version="1">MPPFNTLERENLFRNPSNEKFGAPALQEAVAPHIEAFNSITEFGEGQPGLLDYAVQDLGTMSVFDNADSSINVDPSGAPLGNKLTYWVEDPKLHQPMVSERDTTTLKRRTYPSECRERLCTYRGRLQVKLCWRVNNGPVQSDIRDLGQVPIMVRSNRCNLKNMYPKELIAHHEESEEMGGYFIVNGIEKLIRLLIVPRRNHVTAIIRPSFQNRGPSYTTFGCSIRCARRDQTTLTNTIHYLSDGNVMFRFAWRKQEYLLPAMLVFKSLIDCSDKEIFDALCQGDTSNTFLTDRIELLLRSFKIYNLYTREQCLSYLGEKFRVIMGLDEDLTNLEVGEELMKKLVLVHLDNNRDKFNLLVFMIRKLYALVSGECVADNPDAPQHQEVLLGGHLYTMIIKEKIHDWLQSIKAQVRTDLRLNPARVDFFNNTYFQNSYRKVNSDIGGKLAYFLATGNLVSKTGLDLQQFSGFTIVAEKLNFFRYLAHFRCIHRGAFFAELKTTSVRKLLPEAWGFLCPVHTPDGSPCGLLNHLAHKCKVINQPLDVKAVPRLLASLGVSQSFLHTINRPGDVAVMLDGKIVGWCTPKTAEKVAQSLKVWRVNNEKGVPLDIEIAYVPSTYGGEYPGLYLFSSPARMMRPVKFLGNGKTDMIGTFEQVYMDIACMDDEIVPGVTTHQEFTPTNILSIIANQTPFSDFNQSPRNMYQCQMGKQTMGTPSTVFNHRTDNKMYRIQTAQTPVVRTELYNHYGLDGWPQGTNAIVAVISYTGYDMEDAMILNKSAHERGFGYGTVYKSEIVDLNQYRARGEAITYRFGLDPIKGKKYKNILGSDGLPHIGAHLVADDPLCCYIDESTGKDVVKKYKGPEDAYVEEVRVLGDDAGTGELQKVHIKLRITRSPVIGDKFSSRHGQKGVCSQKYPAIDMPFTESGMQPDVIINPHAFPSRMTIGMFVESMAGKAGALHGIAQDSTPFKFNEQNTAADYFGEQLIKAGYNYYGNEPMYSGITGEEMKMDIYIGVVYYQRLRHMVNDKFQVRTTGPVHNLTMQPVKGRKRHGGIRFGEMERDSLLAHGTSFLLQDRLMNCSDYSQAYVCRLCGSLASPICTKIVSSLGNRRTYECRTCNTSKGIDLIAIPYVFRYLTTELMSMGIKLNLGIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JC68</accession>
    <name>A0A367JC68_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001638">
        <property type="protein sequence ID" value="RCH87528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JC68"/>
    <dbReference type="STRING" id="86630.A0A367JC68"/>
    <dbReference type="OrthoDB" id="2435739at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="134" mass="15008" checksum="DCE47AF0977EB8FD" modified="2018-11-07" version="1">MLSNELCNLANHDWRFHPQAKYYVARLFAEAILFRTDNHQAIIINTIEAYGRGKTVDIYKEIFGMWKGTAVETSLPPAFSISDGKKLLIGTQSCNLLVTSSLRLDKVDDPCVGATTVNFDLQNNSYPLACGKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCC2</accession>
    <name>A0A367JCC2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001627">
        <property type="protein sequence ID" value="RCH87584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCC2"/>
    <dbReference type="STRING" id="86630.A0A367JCC2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="19300" checksum="F08E2F06F0CCE51A" modified="2018-11-07" version="1">MYFLFQVYDRESLDRWVSWFNRDPSTERGISPNVVRNNNDNNNDPDDSPISPDRAAVKMPKNESATFGNMQSEMLYNSSTPSLQQNSSIPQSYPTSFSLSRSAKQGPVGTCSINSPYASYVSNSNFEVSGAPHVTSPYTSFTTSNPNFGRGNLPSNQQNSFGVINENAWQRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCK2</accession>
    <name>A0A367JCK2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001612">
        <property type="protein sequence ID" value="RCH87663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCK2"/>
    <dbReference type="OrthoDB" id="2221257at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48978" checksum="FE92918D75DE4C92" modified="2018-11-07" version="1">MSLVVTKNYHYALLVAIDEGQYFGTKPNLELYISARLDIKLPPTVDDLIPPKTRISTQTTSFTQTPRWRTALIYFISKKFLHTLMRTQSDIKLEIMTVSEDMHRESLGLVELPIDQAKLVRLNREGREMTQVQQFVINKGDWLNVKGAGRAQIKAGLFIVEMNHNTTPATMNKDVATPLQLPVKTNNQPANESDPGMEITDMSNLFDGQGDATFFSDEGENDMLFSKSDYIQNDDEVIEEVESLNQLQDKSEYLIQEEYEDEPCIRVDEKPERYCFLFRLIEAKYMSSIMENYSNVEKAFLRYVLADREYEVKANLSKDKWEVVEYQKGIPFQGSLQKVQEWLSSHEKITVYLMVEYTNGEQDYIAYSDIYLKGRNVDIVEQTTIIYDKDKMWHINQDKIFTILHSKLGLVKGWEALEEDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD69</accession>
    <name>A0A367JD69_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Williams-Beuren syndrome chromosome region 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">WBSCR16</name>
        <name evidence="2" type="ORF">CU097_003175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001586">
        <property type="protein sequence ID" value="RCH87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD69"/>
    <dbReference type="STRING" id="86630.A0A367JD69"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="120"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="375" mass="40829" checksum="096E3B7252958044" modified="2018-11-07" version="1">MQRLNRTVLYGWGQTQALPLLKGSMDRVLNKPQLLKQLDDYALPKDETVTHLATGWGHSLLGTDMNSVYSFGLNKSGQLGNGNISNQGGSKIYSDKENKIKFLACGREHSHVVTEKDKKTQLYSFGNNMYGQLGIGKNKNTVPGELAAESTLQNVKLDGVIEHIVCGLDNTVLATDHHVYAMGWGADGQLGQGCDDKDIPSQVSIDCSIKKLSSSTDFTLLLTNKHTLWTWGNSEYGQGMQGKKIDRILEPLKVNMGRVMDVAAGGPFSIVLTEDGHVYSCGYGALGLGPEMIESLELKEIKGLEKVVKVYASTDYAAALTEDGQLYTWGLNGPSGRLGLGHHEHAFVPNHVNVDRKVLDVSLGVNHAMILCEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDE3</accession>
    <name>A0A367JDE3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TIM22</name>
        <name evidence="10" type="ORF">CU097_009269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001569">
        <property type="protein sequence ID" value="RCH87905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDE3"/>
    <dbReference type="STRING" id="86630.A0A367JDE3"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="16986" checksum="C9ED7E188B72B359" modified="2018-11-07" version="1">MNSQLGGQNSNLSLQEQQTIRMMQAAMESCVVKTAMSGAAGFAMGGAFGLFMSSFEYAGPVMNEDLVKQTTKQQIKHAFKDMGTRSLSMAKNFGLVGMIYSGTECCIESYRAKNDLYNSVAAGAFTGGLLAAKAGPQAMALGAGGFAAFSLAIDWYMHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDJ7</accession>
    <name>A0A367JDJ7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001546">
        <property type="protein sequence ID" value="RCH88013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDJ7"/>
    <dbReference type="STRING" id="86630.A0A367JDJ7"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="196" mass="21246" checksum="7F6DD6E8B2FADF10" modified="2018-11-07" version="1">MNPSHPAPQLPPGWIALWDEGSQRYYYLEQATGRTQWELPTQPSSSLNPVNSGEANSYHSNFPGNSSPATSPYPPQQQSYPPQFPSTNSPQVATSYPGQQQQAYPYPGSSNHQSPYPPTGMEGEQQDRGLGKILKGPGGAIAAGLIGFAAGKLINNHHGGHHQQQQSYYPPPPPGYGGYPQGYGGHYGNHHKPHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF29</accession>
    <name>A0A367JF29_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001452">
        <property type="protein sequence ID" value="RCH88520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF29"/>
    <dbReference type="OrthoDB" id="2288096at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="222" mass="25374" checksum="316B950E6F9EB7BC" modified="2018-11-07" version="1">MTYIYFTCNIQKLPPTPVNVKNTSETALWSTYFDPILSTLLSDPDRNMHLQWSNSAPTERGSARPDAAIYHKQQGSFVGSRGYGEAKPEGTSTHDISVDFLRLAMFCKNSIDVSLLDSTLAFQINNFTITFYLQQLTARGIYASFEIARITFPRSLEDIPAFFNLRNIRLLLAVNKVFWHKCVASDKPATIAHRYCQTIPNWQKNIRTQQDSQRTPSLRIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFU9</accession>
    <name>A0A367JFU9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PEX1</name>
        <name evidence="20" type="ORF">CU097_006014</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001405">
        <property type="protein sequence ID" value="RCH88800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFU9"/>
    <dbReference type="STRING" id="86630.A0A367JFU9"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="492"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="774"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH88800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120350" checksum="EF9B17FFE288ACD7" modified="2018-11-07" version="1">MPKTLIVQFTPIRSCLVHLPGKWVNALLDQKKLPQNVILEISPVDQKTTKKVYCGWSGESSKPLPPNSVFTLGPNGKLDVLEMDPQLGTAIGLQEGQKVNVDFCRNVPECSTVHVEPLTEDDWEILELHAGYVEDNLLSQVRTVYNNQIMCVWIHGKTLVKLVVGGIEPKHEYAKLTNQSEVIVAPKVRKTTQSSPSEESALTSSTPKKMQPSVTVRAAPCDESVGDLCVHVHPDCITSLRNENGQAPQRVRLAKLIPFFLTSSSSRREEEQQQETEEIPIAKALFATLVLSTQVPLRHVMIGSVLKKSLEIKDFDMIKISTIGIKKSSAGSLVLRRFVAPTGPVSTIKLGLESSQQQVQQKLQFEADCTTATKEWLSAQKGEYVISQGMVIDLKVKDKMEQFLIQLATGQSLFSSSTLLQDEEQFVVLSPNQKISIEFGEDISKAPSVDSKKDKSESIKVGGVDKLLNRIEQYTLANLAEKELKASLGVPGSGGILLTGAHGSGKTSIVHQVMRSVRKSLIYTLPVNCSELSDERIPVIKETLQKWLDEAAWHSPSLIFFDNLDRLIPAELEHADSTRSRHIAELFVRMVSRACQRHAIMVIATSQQQQSIHPALITHHVLSELCHLQPPNREERKLIMESIMSQGSDVLKKSLPSIDLVSVASETEGFLAADIKAFIERTVHEGAVRSIKKKMDALKQGVAVDNADLVLTQADFSKARQGFVPSSLRGVKLQSSGVNWSDIGGLNETRKALLETLEWPTKYAAVFSQCPLRLRSGLLLYGYPGCGKTLLASAVAKECGLNFISVKGPEILNKYIGASEKSVRDLFERAQAAKPCVLFFDEFDSIAPRRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDPALLRPGRLDKALLCGMPSVEERLEILQALSSKMKLAANVDLRVYAERTEGFSGADLQGFLYNAHLEAIHGSIQIETFKESNDNKRQEKQNEFVMNDNNKVGLTLAEKGQISQRLAMIKKEIQNVKKETPVKSEVVQPQHEAEITIDYLESSLRSTRPSITIEEYYRLKAIYDEFVTGRTGELPSGEAAKGIGKRSTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHV1</accession>
    <name>A0A367JHV1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001283">
        <property type="protein sequence ID" value="RCH89466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHV1"/>
    <dbReference type="OrthoDB" id="2231703at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="252" mass="29834" checksum="DCE65123777DF5F8" modified="2018-11-07" version="1">MCVKEYPQKEYDEVIAILDLVRSLKDMPCISLPLKESPRMARETEELKNQVELLKEQITDLQYRNSKLAAKHSASLNALEEFSKIRKTEMQREELLQSLRTISMEEELRKTKIGLVNSVAAANIKEFQRQDLEHECKRLKLDILSNTHITEEYGYKIQQYETQLDDYKLQLDTYKSQIEKYKLQLRNCKEQIGDYEDKVEKLQKANIQVSKDLVRLQREHDMETKTLIESFKQKAKAYEEKVRKKLEESQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI90</accession>
    <name>A0A367JI90_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_010629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001289">
        <property type="protein sequence ID" value="RCH89431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI90"/>
    <dbReference type="STRING" id="86630.A0A367JI90"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="520" mass="58198" checksum="261CDD605E8B477E" modified="2018-11-07" version="1">MKTFTIDQVAKHSSENDCWIIIHNKVYDITNFLKRHPGGMKVLLKVAGTDATKQFDTFHNSSILQKLGKELEIGEVSELQEKAEEEETVNPLVVGKPFGDMVPFGDPMWYQDWYSPYYNDSHRALRKFMREFINKEIMPYCYEWDEAKKIPKEVFVKAAKAGLFSSIGHVPTELLPYPLPVGISPEEWDAFHSFIATDELSRCGSGGVLWGLCGGLGIGLPPVLHFGSDYLKKKVVKDCLAGEKFICLAITEPSGGSDVANLQTEAKDKGDHYLLNGEKKWITNGVFADYFTVACRTGGPGVNGISFLLVERGMPGVSTRQMQCSGVWPSGTAYVTFEDVKVPKENLIGKENKGFKYIMWNFNNERMSIAIQANRFARVCVEESIKYANKRETFGKKLIEHAVIRNKLANMIRKVEATHAWIESLVYQSVKMPIHLLPLRLGAPVALCKAQSTRTFEFCAREAAQIFGGLAYTRGGQGEKVERLYREVRAFAIPGGSEEIMLDLGIRQAVKVGTFMGAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JII9</accession>
    <name>A0A367JII9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Xaa-Pro aminopeptidase P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_010494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001239">
        <property type="protein sequence ID" value="RCH89706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JII9"/>
    <dbReference type="STRING" id="86630.A0A367JII9"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="314"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="542"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="67654" checksum="74347BE8F1C6948D" modified="2018-11-07" version="1">MVTNTTDRLTRLREQMKTYGIDVFLVPSEDAHQSEYIAECDQRRHWISGFTGSAGFAIVTMTNASLFTDGRYFLQASQQLDDNWTLMKQGLPGVPTWQEYLVKNISAGSRIGLDPTLISGADAHQISAQLEPTGSTLVPIQENLVDVVWGNERPEAPKNKVFVQPVKYAGKSVQDKLKELRDHIVDQNAYGTVVSALDEIAWLYNLRGSDIKCNPVFFSYSIITEHEAILYIDLDKLTDDVKEHLNAAQVTVEPYSKFFDNLAQLKPKLGEKKLLVNNKTSLAVEVAVGEENVIEKRSFITDAKAIKTKEELDGMRACHLRDGAALVQYFAWLEQKLHAGERIDEVEAADRLEQFRAVQEHYVGLSFDTISSTGPNGAIIHYKPEKETCKVIDPNLIYLCDSGGQYLDGTTDVTRTYHFGVPTDYEKRCFTRVLQGHIAIDQAVFPKGTTGYLLDPFARQFLWQDGLNFLHGTGHGVGSFLNVHEGPHGIGIRIAYNDTPLAAGMTVTDEPGYYEDGKFGIRIENVIIVKDVETPNNFGGRGYLGFEHVTIVPIGRNLIDVDLLSPSERKWVNDYHQECLAKLSPLVAHDELAMEWLKKETLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIL3</accession>
    <name>A0A367JIL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_011026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001228">
        <property type="protein sequence ID" value="RCH89784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIL3"/>
    <dbReference type="STRING" id="86630.A0A367JIL3"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH89784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="104" mass="11862" checksum="9346CE9840EED868" modified="2018-11-07" version="1">MGLSEFFASFVPTVFADEEPQEEQPVEEQEEVVEEEEEEEEEPEDPKPEIMEACAEQCAALKKHLDECNERVENGSSENCVEEFFHFMHCADECAAPKIFAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIN4</accession>
    <name>A0A367JIN4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001227">
        <property type="protein sequence ID" value="RCH89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIN4"/>
    <dbReference type="OrthoDB" id="10319217at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="277" mass="33039" checksum="16129DF04C1309A4" modified="2018-11-07" version="1">MSNYEPLDYLPPSYSAVMAEKEMGQWNMNIHQSMYEAQKMIKLVQLQCDVLQWKNSCYLKQLEELTARSTEEYDISHRLVEMNQLIEQLTKEAEATLYIKPRKRKQKKKKQKKRPCISSLKYIENQRQIDTSINQIMQAIQDLEDDRSSTIRVIHNHHHHYHYYSSHLSSFIQYALYTLTKKSSVSSSSSIRYLSNSIKTKLMLFTTLLISQTFNPHCSPRWARYAQNILSIWKCRSGTQYQFWLDRAQLTLFITQIICKYRPRKKEKRIYACVNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJR8</accession>
    <name>A0A367JJR8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_011806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001174">
        <property type="protein sequence ID" value="RCH90119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJR8"/>
    <dbReference type="STRING" id="86630.A0A367JJR8"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="310"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49860" checksum="0D1B8A99F6A5A2F2" modified="2018-11-07" version="1" fragment="single">MSTGTTTCSHLSRAKSAASLIDKMKQEQSKLEEQLAIDYINKTLNLSIQPGELQKELKDGVVLCNLVNQLRPGTIKTMDNITRFLQGVRQLGMKDSQLFETTDLFSAKDMSSVVHTILSLAELSLKWNSDDGDPSLMLTIENDKDGDSKEGSNHRDVRGIFKETKGTRKKSLTVNVHSDENNKDEKNQSPSPTASNCARPPKSPLRNAKSANSVGSLKVASSSSRFKDQKRRPSVPTLSSSPFIRDDESKRDFFTKPSDLQKKRQESAKSAIFTEPTQSPSTDSRRESTMAEAEGKLVLTNDQDETITQYQLGNCIGKGQFGAVYRALDLATGEVVAVKRVKLEEEELYQEIMKEVNILKTLSHTNVIKYIGFIRSEEYINIVLEYAENGSLMSTLKAFGAFPEKLVASFCIKILKGLEYLHANDVVHCDLKAANILTTKTGDVKLTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLE6</accession>
    <name>A0A367JLE6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ERAD-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HRD3_3</name>
        <name evidence="3" type="ORF">CU097_009083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001072">
        <property type="protein sequence ID" value="RCH90758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLE6"/>
    <dbReference type="STRING" id="86630.A0A367JLE6"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016613432" evidence="2">
        <location>
            <begin position="27"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="691" mass="79260" checksum="2FD8B3F0631AD28A" modified="2018-11-07" version="1">MVRLGRKHIIPLFTLCCSCLIVNTLANQIVVTSVEKNTDNNGQQLYNLAIEQLQEIEKRHSHTQTYNNKPTGYLQYLFSLFEQTTEITTTTFNKESHQDSRVSKEYHDAITLLQEAATTFQNNDALLLLAELNFFSKYAHPRNYQQAFRYYNELAGKGNATAQYMLGFMHTTGIGVQQKDEAKGSIYYTFAAEGGDTLAEMTLGYRHLYGIHTDESCEDSLRYYRNVAEKAIRHYLSGPPLGRHLPFAKVRLPDEQGGIYGFTASPIADKKRAQRSETNMKELMQYWKYLAESEDDKEALLMLGKVYYFGTRDIPRDYTEAIKYFKQIADKKLLTSANRKKEESKILGQAAGYLGLMHWRGEGVPASVKHAYEWFKFGLTFDDPASQNAIGLMYKNGIGIDKDQRYALHYFKAAASQNHPDAMVNLALEYAQDDITLPTAIDLLTKAAEKEHLLAYWYLGQLNDQGYSSSRSCRVAVHYYKAISEIGDWLHPTVEQGYSAYKQGDHESALLFYTLAAERGYEVSQSNVAYLLDPGKKKEKDKPTQFFSNENITDKRVWDFRSLFTKQEKPRDIEGERTAFTYWSRAAHQSNIDARVKMCDYYYKGIGTKADPEKAAACYRNAAENGRSSLAYWNLGWMYENGIGVKQDFPLAKRAYDNALATWPDAYLPVKLSLLSCLRKWWWHRMTSKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMG8</accession>
    <name>A0A367JMG8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_007881</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01001016">
        <property type="protein sequence ID" value="RCH91126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMG8"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="15">
        <location>
            <begin position="353"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH91126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="622" mass="69717" checksum="3D19B5863F93EE25" modified="2018-11-07" version="1">MATNKNNESSVISYHEPSLLPQNVASMVTTVSLATRVSLKCSSLLVDTIFGAAKYGTSMSLCLSRNAITHAISTAKHLHSNDQDNLFIKTLEKYTNAGLDWVSHTFSLAELLAISGIQFTSRTIQSTLKAAEESVRIFDNIFGSNETSRAIAYIITRLNKEFLHDPDFDLAKAGRIAVLTGLTKALTAFAVLQNVTYKRRTIPSTLLWEANVGEDPEERQRHVLQFKLNEDAPPPYYSTYHTQRRFSIPVQFYCDETKKCNSMPMLYPIAHFIRYASAAYGESFMRILGIGDIPATLPNDHHPNHHAFAHHTNNSVQDILLSTYTDPSPFLKNPALNALVHYVTVDHTAKAIVLTCRGTLGLSDLLTDLSFDYSEFTVPATDQVFMAHSGMLKAAQLLAKQKGKVFQKIRQGMTMYPDYGLVLCGHSLGGGVASLLTVLWSQKRGAKFTTSSQSGLPPGRSIHCYAYGPPGVMSLGLSHYCQGLVTTVVHGYDFVSSLSLGLLQDFKNVARNLHAEENVTEEIISRVMQRMKKRQEEEQDDDEDQWFWAMIKTMRADMNAEKMYPPGTVYLITTENGKVRLSRCDDVHARFSEIVFSRTMFMDHSPYLYEQAIQKLYQIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMX9</accession>
    <name>A0A367JMX9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000990">
        <property type="protein sequence ID" value="RCH91292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMX9"/>
    <dbReference type="OrthoDB" id="2290994at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="693" mass="78115" checksum="86BDEBEB0022AB43" modified="2018-11-07" version="1">MGQSTSVETAKNTDDEEEQIQDKRARSKKFDLKNINDHTQDDVTQSPTDSFFPIMNTAEAPSDETVAMSSSVVETTSSLKENSFKSNRNANNSVGIASKIIPKRPWSSYHLFQLANTTTNNSISDSKARMIRSPRIRPRETKGTDTKSKTRIKFAEPPKPIFNNNRHQLEKLAKQNAEIDEIITMLHHHKISEDEPIINQTNDYVPSSEFQFSFPTANNNGTHIPRQQYLVPPPPPVIINDEEDEDEDEDDLQHDNNNNNNNNQFKYDVIKNRKILPLPKRKLRRNLDSTSGVSSNGSSALSSPIPSLPSSPFTFSSDKPMPKVSFLTDASRNLLQQQQQQQQQQQQYQGQDQHTQQQSQQQQQDSSNVSSVVDSTHNRKDRPNMSKKIKSMERVHTTPLNDEVTMIGKRKEITSNNPVFKSPPKMEVFTKYNPPKVFDFTNFNFQFNPDLNNNNNNNNNNNNNSSSSSSNETKKMIQNTHKPTQIPFIAPDQPISTATSNDPSTNTTTSITIPAFGQHATPGKPIKGLESKKILSAKAPSVAIKRPSISQPTNTATNNSTSTATTKTKVKQEGESKKKTATSNSKSNKKNKKSKSKKPEEASPGGFLSSDITLFENPLSDDWICFFCQFDIFCRGFEDAKKKNGYYKRKKERLRRANEARRIAAGGGGGVESSEEQLEEEHRHYHHHHHHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPR8</accession>
    <name>A0A367JPR8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000899">
        <property type="protein sequence ID" value="RCH91944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPR8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="25383" checksum="13D3BD94CCB0E107" modified="2018-11-07" version="1">MFGWIIGTSVGYKCLTYTCPEQSNSDLSSSTAAGTTDQDKQSFLITRLPKAMIHQWKQISSFRQHSVKSRLSSNDIKDQKRIHSYYHDPNISPCSTAVADEEKGHFHVHAAQKIKKTPRGRIAALVMILFGFLIVIVFIIMGLGKATESNEDSIDSMQNSTISASFIDANKLMMMPTTHLPSQTHSQTELMPTPIHDTVTRFILIEDASVLSQIITQAGVTPSYLPIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPS7</accession>
    <name>A0A367JPS7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_011645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000900">
        <property type="protein sequence ID" value="RCH91938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPS7"/>
    <dbReference type="STRING" id="86630.A0A367JPS7"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="123" mass="14104" checksum="C74BEC86DB451E80" modified="2018-11-07" version="1">MEKFKEKLNILREQAESATAAGDEYANLIKQLEAEDIQKSHEINSLQSKIKSLEDQLEKTENKLQAISLKSQEADIKAESLEKTVSELENQLENAESRYDELQALNKATMEEMAEYERQLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ28</accession>
    <name>A0A367JQ28_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CU097_004323</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000918">
        <property type="protein sequence ID" value="RCH91801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JQ28"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="139"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="733"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1058"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH91801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1511" mass="171921" checksum="41B49A4BD79A5BDD" modified="2018-11-07" version="1">MVFIQDPIAQSLPRLYVLTLDDDGSPKDKSYIRIPLFKGEVILRFVLEPGTLAAGGHPRLITNYPIKGQFERHKFHPVQFTTHPHLLHAYCDIKIDIPGAYQYQVEYRCEGQNKASQAGYVIAEPRISLPQKEKKESLLPLDGLVVLSVVPKWMGPITEWANLLETVDYSGYNMIHFVPLQKRGVSNSPYSISDQLAFDDDVFDAKDQKKSNKERLAIVKKAIGDIYSKHGILSLSDVVWNHTSNSTDFLLHHPEAGYNLHNSPHLVPAYELDTALIELSGQLEQLGLPVDIRSEQDADVIIDYIRENTFKQLKLYEYKVIDVAKQADVIRKALKDRSEQSSHPTVYHDVYNMDIKKRIALFGQDVIVNGHLGTRFHKTVHVSAALSFLLAFNKIKSLDEVSDDQVNGLVESFKNLLNDYNLPLYEEYDEECKVALENIKGRLLFTRLAENGPKLGRISKNNPLIESYFTRLEDLKEKHPKGSMMLANNGWIWNADPLKDFAGPDSSAYLRREVIVWGDCVKLRYGQSPKDNPWLWQHMREYTEQVASMFHGIRIDNCHSTPIHVAEHLLDAARRVRPDLYVLAELFTGSAERDNDFVSRLGIHALIREAMQAWDTHELSRLAHRHGGKPVGSMDEDMIWKVVPYECDEKKKVLSIPITSGSMPRALFMDCTHDNETPFQKRTAEDALPNAAIVAFSDCAIGSVKGYDEIYPRLLDIVNEKRRYNPNPKHETGIIEAKRKLNLLHQKMCLEGYHEVHVHQENDFLLVHRQHPGSQNGYLLISRTAFPGQGTGHSPIRLRRSTVDFEFAYSLKVDSKTLPEKEDFLQGFPAHLEKLEPPQVVQNEDEKGPFAEIILSDRFTPGSICVVRTSIGDKYAEIHELVTKMDDDVFKNMNLTDCNVVLYRCSSEEIAATSGDSVYVVPNYGELVYAGLQGFMSVLKPIMANNDLGHPLCDNLRAGLWAVDYIIHRLRVHLKHYPNLASLINWFESRATLLHSLPDFLVPKYFALTVQTAYDKIYAHALSLMSPLVQQGDKFIKQLAMTSVQLYGIVPNAGLSPTESTASLAAGLPHFTVQHMRVWGRDVFISLRGLLIVTGQYEAAKDHIISFAGSLRHGLIPNLLDSVRYPRYNSRDSVWFFLQAVQDYYRLAPDGKSILQAKVPRRFPKDDQFVEVEEGYKYSVTVAELVQEIMERHARGIHFREHNAGPSIDSQMTDEGFNIDIEVDWSSGVLVGGNVWNCGTWMDKMGESPKAGNKGHPGTPRDGAPVEITGLLKSTLRWINELVARKEFKWTGIDHIGQENKTITYKHWNDLLQKNFERVYYVPLDASKDSNYDLITKIVNRRGIYKDVYKATHAYTEYQFRPNFAIAMAVAPELFDKEHAKEAIRLAKNVLVGPLGMRTLDPADQQYRPYYNNSEDSEDFQTAKGRNYHQGPEWLWPLGYFLRAATYFDAISQQDIARIMRQHRKYIEENVWCGLPELTNKDGAFCGDSCTTQAWSAATLLDLLHDLIEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQP0</accession>
    <name>A0A367JQP0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000866">
        <property type="protein sequence ID" value="RCH92179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQP0"/>
    <dbReference type="STRING" id="86630.A0A367JQP0"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="448" mass="52032" checksum="F6DA1F64ECEFCF7C" modified="2018-11-07" version="1">MVYPHNNSLYNYLNNNDNYGIPIAAPHGRDVEMTEASLVNERPNKLRSKRILHYRSMEPEIIEWNMKKEKRLDFTSILPFELCLQIISLLDFNTLLSVPLVSRRWASLFYQDELWKIKMVENNWRLKIPTNVTLTEEEQSWYYWYKQRHQLEARWNTGKVASHYLMGHKDGVYCIQFDDDKIITGSRDKMIKIWDPQLYQCIYTLEGHAGSVLCLRYDDEIIVSGSSDTTVIVWDMRTKRIRARLHGHTAGVSDVAFDDRYIISSSKDTSIRVWDRKTFQPIRMIVGHRGAVNSIQIHGNYLVSASNDTLIKLWEISSGKMIREFVGHHHGLACVQFDGRRIVSGSSDHTIRVWDVETGLCTMIFAGHSGLVRNLRLLGNRVVSASYDQTVRVWDINSGACLLNFQSGHSSWIFDVHFDRKKIISTSQDRKILIMDFAHELNTKCLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQR6</accession>
    <name>A0A367JQR6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VPS51</name>
        <name evidence="4" type="ORF">CU097_008563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000856">
        <property type="protein sequence ID" value="RCH92246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQR6"/>
    <dbReference type="STRING" id="86630.A0A367JQR6"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="705" mass="81695" checksum="C4C6CE92E6C6F783" modified="2018-11-07" version="1">MESNAASVRRQERNSILKKYYGINGKVVNNQAVVEERPFDLDADTFNSSKYFANLLKEKTLRELMEADNSLVAEIREIDGDMKTLVYENYNKFISATDTIRKMRSNVENMESEMSKLKENITTISNQSKRINETLRPNRTKIQQLSTAHNSLKRLQFLFDLPSQLQHYLNRGKYLQAIQYYAKAKRLLNNTAAFKGIEEECNVIMEKVKQDIWSQLQEREASLETVAENTRLLVLLGENKSRLCREQTTALQRKQSKQAESSTVNDMLSNFIIPLEDIVNHFDHLFLTKDDLDSAEKEEAKQSLLDAIQPFIDAFFALVKTFMQLPNEIPDDLPKQIDYLCQLKDAISSRAVSLDSITGISKRMDVFGANWKNELINKIFRTAIDGVRDRIQEFIKEIKMMDKDTDRMVKFIQDTQAWLTDHVTKSCLLPLKTYFAKESPDRVRHGLRLVWEDITKVFQSVAKNVILDRHLLQIVMLAISRLCYDLADNSVYQTYTIFSYEFYIKTQEVGYRAPSLDPTVIPDMNAVIEQCLNIGQSLLNQQIVHDGYRLSTRVQEAYLFREPSSVVNQVSPIWITIFQQLKQIEVLMSALFPQQQQQQQQEKDKDVEDEASATLSTATEGVIERFGIDMMMNYSIDKLFAERIEVYRKLEPTPASVYHGLVIILLKAFLEVTRQIQMDTIMFQQIQVDVEYIGRMVWSFAGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRF3</accession>
    <name>A0A367JRF3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000819">
        <property type="protein sequence ID" value="RCH92498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRF3"/>
    <dbReference type="OrthoDB" id="6363407at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH92498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="202" mass="22646" checksum="5B5B33B48E757BB3" modified="2018-11-07" version="1">MSSFIFRKSLLQSRQVVRAPTLKRTYATHPEQNRASNSNGVYLALAAAGGVAYYLYSRSGKAKDNKVEVVQDKVNQVKEKYQETKDEAMEAAYGAKDRYEQAKHDAKEKYDDMKDGAMQAAYGAKDRYDQAKHDVKETVGSKADEAKSKYEQSKDDAMQKAGEVKKEGEKRLGDAKEKGQELQEKTGEKVKETGESIKQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRT7</accession>
    <name>A0A367JRT7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_010978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000832">
        <property type="protein sequence ID" value="RCH92411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRT7"/>
    <dbReference type="STRING" id="86630.A0A367JRT7"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH92411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="99677" checksum="0ED803A41D9E7F2C" modified="2018-11-07" version="1">MTQSPLNEETNSINDQLSTSSTSYHTETGVHNEALSNDDEQHTQPLTAELLAEQNELNKVLPTPNAIRAWAADLPEVPDSVQPVLTSSHVFEVDMNQTNTGTIHETKDVFTETQKIAYIGLCYLTSLEVVHDYQGKEFAMARMSADNWQRKLMRMLYAHMDISGEEIKMIESLSKHSILPTDLVHQFTSQGDTAEVKLDDFVKNNNAIDDDKVIIDLRWTVMCDLFLICLSNENYDARSRVFVARIASYLSLDWFQVIGFEKRIAEHLLQDVSWETETVNSVATTMTSMTMTNAEGDGSIKSDAERYGRNKQRKKRRYVMVGLATIGGGLILGLSAGLMAPVIAGGLGVILSTVGVTGTASFLGGTAGIALITGGATVAGGRLGGRSMSRRMKSINTFDFLPIHSEDNVSCIVTINGWLSNKEKEEASLPFSTLDAIMGDHYTLYWEPEMLEELGSAFKILATEAVTFSIQQALAHTIMGALLSGLAWPLALTKIGYMVDNPWANALDRSKVAGLVLADVLMNRNLGSRPITLVGYSLGARVIFYCLLELARMKAYGLVENVVLFGTPVSASKAQWKECTTVVSGRFVNGYATNDWLLGFLFRTSTAGLGNIAGLRPLCHIEGNRVQNLDCTDLVTGHLSYRTSMPKLLKRAGFMVSSEELPTPKEKSTGGIVSFIKPKKGNLEGEMPETETKNKQIDSVKITTSLSSLSSGKASIQIAPKATSSEPSDCDRNSSSSDLIPTPSTTSTIPSISSNEKKETTDYEIIADIIANATAAASSKSGTYSSLSSGKASIATETTQQHRRSTLTNLFSSNRPRSNSAAKASITTNSHHKRQSTGSSTSSSNSHRSSLIFGASLFGIKKKTEEEDPAKRELRDAGVEVKEIKSTLGCLVVPKEVSNPMPQVKLELPQHARLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS31</accession>
    <name>A0A367JS31_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000819">
        <property type="protein sequence ID" value="RCH92501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS31"/>
    <dbReference type="OrthoDB" id="2288006at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH92501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="13777" checksum="031FAF236264262E" modified="2018-11-07" version="1">MKTSNPEKSDAYTISWHLVKPHTEKKFNAFENKSELSEGDVVVKIWRPILEVLFSNASVVLHCGDTLSQLAQEGKMAHRRMDLRLFFSSGSSNDVGDVEFGKMACVTKLYYDNEKSMTNGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUA4</accession>
    <name>A0A367JUA4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000687">
        <property type="protein sequence ID" value="RCH93520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUA4"/>
    <dbReference type="STRING" id="86630.A0A367JUA4"/>
    <dbReference type="OrthoDB" id="2277655at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="315" mass="35467" checksum="E29106B095D7E6D7" modified="2018-11-07" version="1">MLSTSDSVTKYMPQSTRVLVKNELNRLYSAAPVPSTNLLVWTNTLRTLRVGWMEMKKKCNEIITDTIKIKDTNDLIASFILFELVPRLTKEVDADETATCEVKPPSKVGRGDISDFVKLGIEMRHMLDEILSIGVDDASVLDILVEDNFFIKKSGNRKRVSTYAMNTKSGIFRMIQLGEYNVIEKLSELGHFPALFTGLMQVKNIALDIARAIEKTERENSRGKKRERVDKRKSAGSIPTLKKLRPNASLEDEDGRGRSSQINDDELKELVESNSSQTIHELAKQMGVSKGAISRHIEIIGKIKKLDQWVLPYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUI3</accession>
    <name>A0A367JUI3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET8_2</name>
        <name evidence="9" type="ORF">CU097_003114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000672">
        <property type="protein sequence ID" value="RCH93642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUI3"/>
    <dbReference type="STRING" id="86630.A0A367JUI3"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="247" mass="27754" checksum="CA51F04AAEC3EA15" modified="2018-11-07" version="1">MAYSKKYEPIQGGGSLIVAYQIANKKVIIVGGGNVAAQRIVSLKMADAHVTVVCPESGLVEEVRYRIENKEVDWINRKFIDQDLDHVDMCLTALDDHEESLRIGQLCRERRIPVNVADVPPLCDFYFMSQHRDGPLQLAVSTNGQGPKLANMIRVEAAKSLPPNMGSVIERMGRLRAKVKEWEPSMKNSGKRMTWITLLCEKWGLDGMAKLNEVDEEHEAAVFEELRKHFLIGSVPSVEDILSRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV99</accession>
    <name>A0A367JV99_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GLK1_9</name>
        <name evidence="16" type="ORF">CU097_012398</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000648">
        <property type="protein sequence ID" value="RCH93860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV99"/>
    <dbReference type="STRING" id="86630.A0A367JV99"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24018">
        <property type="entry name" value="ASKHA_NBD_HK_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="14">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="15">
        <location>
            <begin position="226"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH93860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="486" mass="53815" checksum="47C3201030454A26" modified="2018-11-07" version="1">MPSNTKAPEAHEVQEIGGTPEQEAYMQNIIEQFTIDTEHLVKIRDHFISEMERGLSQEGATVAMIPSYVEGRLTGKEQGRFLALDLGGTNLRVVLVTLEGEGKFKTVSSKAKVSEALKVGPMRKLCDYIAECVDTFLTEQGLEDQEMELHLGYTFSFPVLQSRINRGILSTWTKGFACSGAVNKDPVLLLQDALLRKHVPVKVSALVNDTVGTLLSNAYNKPGTLAGLILGTGSNGAYIEKMEKIKKWKEGKTTSDEMIINMEFGAFDNERKVLPLTRFDNKLDRQSINPHAQIYEKMISGMYLGEITRNVLTDMIDRELLLKRGPHQSVAWAKDISRHWSFETAFMSNIEADDSPDLSHTKEILDTNLNMRDVSTVEARIIKKVCELVGKRAARLAAVAISAIVKHCGIGPEGHDIGIDGSLYEFYPSFESRMYEALQEMMPEVEDIPNTIRLGLARDGSGVGAALTACVAARMEGQRMAESPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVW5</accession>
    <name>A0A367JVW5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF647 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000625">
        <property type="protein sequence ID" value="RCH94045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVW5"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="102"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="7">
        <location>
            <begin position="367"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55426" checksum="387389D925F761C2" modified="2018-11-07" version="1">MFRCIHQLPKHSYRHVFRPIRLYTTDHGQPILTELVHGRKRIYTSLPTIAKTKSATASKSRIASPVTSSPLSWEWIHPSEEKEGNYYATSKQKNNGLGVVSAVKQNLTEMFLPVGYPDSVHSCYKKFHAWLFLETYVGSAIGVLCSQAMLASLGLGTEAATGGAVAIQWVLKDGFGEIGKLFFIKKYASSFDSHPKTWKFVCEIFSTVGSFLQLCTSVVGPKLFLPLAAVGNMFELIHESIWIASHMTFTKHFSPNGNIGDIVAKDDAQMSTAHLLGMLSGVGLISISHSPAFLFGAFALLSPINIWSTIKMLHAAEFEILNQAKLTLLAKEYIDTGKVATYEKLRSREIGFGEWIKPSLRNKQGSVSVKIKMGSSAAQAYSSSHEVQDVVQVLMHENYLLNYHKNTMWILFHQDAGSPDFVKSILHSLKFHDIISTENIDKDMHWDNYIDALKSSHAWTQEHYERFSLELDEKNWQRDTVYWNDRQVLNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW28</accession>
    <name>A0A367JW28_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DDX42</name>
        <name evidence="14" type="ORF">CU097_013314</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000648">
        <property type="protein sequence ID" value="RCH93861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW28"/>
    <dbReference type="STRING" id="86630.A0A367JW28"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="265"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="470"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="617"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH93861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="698" mass="77971" checksum="E5CD75F634B4368F" modified="2018-11-07" version="1">MNQPKSKTFNFGFPSKKNKATQEEQSVSEGKRKITESIESSNKKLKTIDDEDELLASAGLGPSISSVTEQQQQQEEEEEDPLDAFMADMNEKAKSEKSEPKIRRDDIEEEDELESYVRHMKEKGITIGANNQPLPEIDENANSDDEVYAAAAAVDRLEKQFYDDDDDVTTATPTKKEIEPLARVDHSTIEYIPIEKNFYEEHPDIAALDNERVKALHQEMGITVSGYNVPKPCISFAHFGFDEDLMNAIVKAGYTEPSAIQRQAIPAALSGRDIIGIAKTGSGKTAAFVLPMLVHIMDQEELVKGDGPIGLILAPTRELAVQIYQESRKFAKAYGLKVGAVYGGASKLDQFKDLRSGTIEILVATPGRLIDMIKMKATNLKRVSYLVLDEADRMFDLGFEPQVRSICDNVRPDRQTLLFSATFQKRIERLARNVTSDPVRINVGTTGQANEDITQIVEVFDDDTWKWDWLMRRLAGFCIEGSVIIFVSRKDSVDSLASSIQQNGYQCVALHGDLQQYEREKVLREFKQNKAQVLVATDVAARGLDIKSVKIVINYEVAHDIDSHTHRVGRTGRAGEKGTAYTLITQKEDRFAGELVRHLETSGQAVPSELLNLAMKNSRFRDARSGRRGRGGRGRRGRGRGNANHTPIMPRSTAGVGYHSGQHTSSGMIHFQKSSTGDLHTISQQQQQQQQRKPSRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW71</accession>
    <name>A0A367JW71_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000608">
        <property type="protein sequence ID" value="RCH94180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW71"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="86" mass="9762" checksum="978FFC466EFBA222" modified="2018-11-07" version="1">MSRSKDSYYHRHERHVARNGLTEARYGLKKMGAGAANWGVLGDEIPDVQEIARSDLDLPMNNRTSTKLHLVDSDTFNNMRLEQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW95</accession>
    <name>A0A367JW95_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_012467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000603">
        <property type="protein sequence ID" value="RCH94213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JW95"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="6">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="8">
        <location>
            <begin position="453"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="7">
        <location>
            <begin position="960"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1525" mass="176289" checksum="A51CB42F8BC92D59" modified="2018-11-07" version="1" fragment="single">MIDRIIDQVVDELALKGENGCNFDQLWIHVKTIVEEITRELPNKIPININDQYKAYLWTYLKSNKDVLFFQNGNRLDIDSLTWTDIIAIKDNIIVKTTDEIQDAVIYGKAKHIKKSLSVMHKAVISEIAKRKDKGITQYALGTLLNQDAKKIFHYLKKFEQEGIIVKRDAYAKGMNTNILYLKRFAPQSGQIEPDKEDIGFSDVICTYDEFKLRLLNELNNAKNNMMSLSDIVDTLGFKTEYQKRWARIRISYLHDHGEVEKFHAFDGKKLRAAVRLCKKEAKSADTSHEVKNASSPKLYRDVICEYQLYQAIAEAGEKGISRQELADRFPYLSTDYLSYVLTNITTAPKDPKLADYRVYKTEVVEGRQRLYRYFALNGWLRHNKMLKTQFAEPGTLKDLAANGSQHDMTLVNTIPQKRKSTVDAPIVHTMIEDKTQTMTPEPVKKRKRASHSSTKLRRVGILLDMLEKEHVRELNARMVNEFNELETATEGGQPIAKVTLGKLAKQLHEENKLKMHVTSIRRSSGIVEIKTLLLHASLSPESEQVKRFIENYEIEQSAMTLSVKQNRQILKKVPVPELPPISSNLTFMGENSTPGKDNTTVPSGTLYEGSISRNAPVDYGWVQSKILRAKEMHRDILKQYFATHSPLEHEERLLEMNQLVPSLTIGTLVKLCARLPFENQDFLSYISIHENRSTQLRSLPYAIRTLILKTPHKIRKPILRILDVLVTLELIEVCKSPLGRTMYKLSKYGKVKDYCSPNHPILTTLPINNMNDVDTYWKELRFYCVELRHGEKIHRKECIERNSPIANITSRRSWATSILLSKKQKEMLDTHIDFQSLTVPVEDANLRAYLSKKLDIPATRIRTYFMAIAKLFQRKKMKHNKQRRKSTIIRPSPAIHELMKASAEKRKVDTADPQIRQTPPFVQRTFIGSRKFRKLRVRVQPKEDMSEGGYSMNYDPLPEVEKDVLLYSYCIMRSRAKRSLFYWSPITKVLPHREPEKCRRTICTMALMDHTLVHTIQRLTTQWEHIYKQGIEKGDICDDSPWDSIHFDLRGYLEYFLLKLQEGYESTDNTAFDAGIEMYALPKNCDTLYRQFYILKEEFKDKSNVDRVPSQSLQIPEARVGPQYRPYLDKHQQYEHEVLVELVKTLIKTLLVIPLESYTPKDAYLLMKQYPESAIEEAFNQLKKNGLVVYDRSAYGRIPGRLINVSEKFMTLASSVLPHDLFQEARSHYLNLANHNSVILTKDINSGQVAATLDLLSQNKICLDMADRANYIQSKQSVIYPKLSAVPLCELYVYKGLDITVRCTKDLQLPTPTLKWKHTRVIPMDHINHYLTMIKITNPLSHHIYMALKEYGALGASFDCTSTKIRDSNPHIQNVDIVTAFDTLIKHDPPLIYLVGFNHLRYTVAEHVHHWLLKGTKKDTYLDPIIWCDISGSIVHPVLDGCCEVVMSHITKRPGIQYAQLRDVLIGFLSEYELYTILKYLVDKNKVISKKVCQSTNRRSIFGKKKLCLSKNELHTGEQIHYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWI4</accession>
    <name>A0A367JWI4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000629">
        <property type="protein sequence ID" value="RCH94011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWI4"/>
    <dbReference type="STRING" id="86630.A0A367JWI4"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="297" mass="33356" checksum="7427B9B56F56CBB0" modified="2018-11-07" version="1">MANSSERVFILGGTGNVGSKTTRDLIAKGIPVTLYARQPEKAKALFENNSLVNTIQGDYKDLAPLKEGLKGHTRLFLLIADMYNMIHLKKTIAAWAYEAGVKQIVDISSFTVSCPLRTTFIGVNHYESEQAIYHLPNRGAYVALRPGRFMSNILMFDGFQFSKDTIFDTIDADKPQGWVSPNDIGAVAAVVLSEDIEKHGDSVYELNSDVATPAQRAAYLSRILGREIKYKKIDSLEKYDMLMSTRHLSHPFAYCLSANLASYDMQNPTITDGIHILLRRKPETLEKYLEDNKHLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX46</accession>
    <name>A0A367JX46_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000578">
        <property type="protein sequence ID" value="RCH94439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX46"/>
    <dbReference type="STRING" id="86630.A0A367JX46"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017083661" description="Histidine kinase/HSP90-like ATPase domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="61"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="156"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH94439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="738" mass="85219" checksum="99407D0D597D0650" modified="2018-11-07" version="1">MRINFVFLFLALLLSSFVFAAQEKEDDIVQKIQDAGDHETYTFQTEVSRMMNLIINSLYKSREIFLREIISNASDALDKIRFLSLTHPEALESSPDLHIQIKADPVHKTLTIRDTGIGMTKTQLKENLGTIAKSGTSEFLAKMQDNNKDALNQIGQFGVGFYSVFLVADKVTVASKSNDEEEQYVWMSEAVNDFTIAKDPRGNTLGRGTEITLYLKKDAERFLNEKTLKELVRKYSQFITFPIQVWSAHEVEEQQDDKDELDEGETKTEPKKMTVYDWDRVNTQKPIWTRDAKEVTDKEYNEFYQSLTLDRDEPLGWSHSKGEGELEFRSLLYIPRYMSEKFYQTMQDIKPIKLFVKRVFISDEFDLLPRWLSFLRGVVDADDMPLNVSRETLQKHRNLRIITRHLVKKALDMFSQLSQSNPDKYNAFLTQYGAMLKFGAIEDTAYRKKLTSLLRFASSHNTTAYSTSLDDYISRAKANQKSIYFMTGSSVSEIEQSPFIESLLARGYEILYFTDPIDETFVEHIPGYNGKMFVNIAKGDLELEDSMDTKEQEEKYKPLADWLKDILFDHIDKVTISQRLTTSPFAIVAPKHGLSGHAQRVLDAQGHNVKNPQMEMVLESLKLQKKILEINPNHPVIEKLLSYVEEDNMPEDMTNLVQLMYETTSIRSGFPLKDINQFTSRVEGLLRKNIGVAMSEEAKVEVKKAKEKTEQERLEDEEMKKTNVVYDDLNEPIEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY90</accession>
    <name>A0A367JY90_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha 1,2-mannosyltransferase 2.4.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KRE2_1</name>
        <name evidence="4" type="ORF">CU097_000665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000524">
        <property type="protein sequence ID" value="RCH94924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY90"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="216" mass="25524" checksum="5FE51E621E842A29" modified="2018-11-07" version="1" fragment="single">MLLRRYSYFLLQVGLASYLLGSLFYYFGRKTSVYKNAITSIANATYWELKNTEPAESYTVGPPYVSNGITVTLPPASNTTERQKAAFIVLVRNSELQGMLDSMKDVEDRFNHKFNYPWIFLNEEQFTEEFIKSTTKIASSKTHYGFVNESMWSYPDWIDQKKAAMCREELSYVPYGTSESYRHMCRFQSGFFWRHPLVLSLDLEYYWRVEPDVRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZC1</accession>
    <name>A0A367JZC1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRPL43_1</name>
        <name evidence="8" type="ORF">CU097_014248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000482">
        <property type="protein sequence ID" value="RCH95286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZC1"/>
    <dbReference type="STRING" id="86630.A0A367JZC1"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="138" mass="15677" checksum="527362C8F395084A" modified="2018-11-07" version="1">MSAFASRLLPKTNNGTGAFVLQCRKMVFNYCEKWGSNKGMIEYIKKDLIKFATENPQIEIVVEPRPAHHPVIRGYYLNGRDKVICTRNLSPSEISKKVQLLRDSSGEKMKDLTKKPVISTTESVRGIWSPFHSNPHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0A4</accession>
    <name>A0A367K0A4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CPSF2_3</name>
        <name evidence="8" type="ORF">CU097_013601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01000450">
        <property type="protein sequence ID" value="RCH95598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0A4"/>
    <dbReference type="STRING" id="86630.A0A367K0A4"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH95598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="497" mass="53966" checksum="04F1C4A96A842F15" modified="2018-11-07" version="1">MTHQYKTVIIIGSGLAGLSAAIEAHNQGNTRVILIEKEDKIGGNSMKATSGINAIEPLTGDNRDAFVQDTLKSGGGLSDESLVAKLVDESRPALDWLIKQSEFETDMPSLDLSVVSRCGGHSFGRTHRCPPQNGRPVPVGWKLVDTLKKRFMSLSDTKVLTNTRVTRLLTEQDKITGVEILNEEEKREISANAVVLATGGYGGQTGTRLSDGHATLLSEFAPQLVHTATTNGPWANGDGIRLALAVKAGLRDMDQVQLHPTGFIDPNQPTLPTKFLAPEALRAYGGILLNGDGKRFVDELNLRDHVTDKIIHQASTVYHRPESWMHKILPKKYPAAYLVLTDEAVEKFGKSTLGFYASKGFFAQVEGIDNLAKDVLGVDREEVEQTFKEHDSHIESASPDDFGKTVFPCRLLPENSTTYWVALVTPVVHYTMGGLNMNTDAAILHQDKQTVIPGLYGAGEVTGGVHGRNRLAGNSLLECVVFGRTAGRNAAIYSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0M5</accession>
    <name>A0A367K0M5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000440">
        <property type="protein sequence ID" value="RCH95695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0M5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="8822" checksum="39DCE8CB92D2D95E" modified="2018-11-07" version="1">MFGAQNCEVKTWKGGCAYTKQFCQGTEWSLGGGVFGLEASLGASSKVCFGYEHSCSEDGKQTWTKLYSNMLREKVTGKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0S0</accession>
    <name>A0A367K0S0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000430">
        <property type="protein sequence ID" value="RCH95803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0S0"/>
    <dbReference type="OrthoDB" id="2219121at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016654918" evidence="2">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="181" mass="20041" checksum="F592C56524D65E97" modified="2018-11-07" version="1">MLLLVLFFFCFQGLLALSTFNVTLPEPNAPFVAGQMLPISYTLPDDPNLSRTLHLSILFTTTDPSLNHTEAVITSNADTSQSFTFRRVYNTTVYYEHQLSYSIPNNTHPGQYSIVFVDSITGTKESVPITVRPYAQPAPPARPSGKPFFVISEAPAYVVVTLSSMTTYCSLVVFIITYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1E3</accession>
    <name>A0A367K1E3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_002972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000405">
        <property type="protein sequence ID" value="RCH96062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1E3"/>
    <dbReference type="STRING" id="86630.A0A367K1E3"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH96062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="47730" checksum="6272697B97B93C97" modified="2018-11-07" version="1">MIQSWTIQSRLLITRSFSSATRKVHPPVHSGVIEPLHIKPLMKKPEKAADRLLSAIRRGNGPAAWKAYMNLKNAGHISQLPELYHSMTVQTFQLKDNGTYSPNYLKFYRKCVSDILETAIANGYILNSRDYNLLLKLYGRSRDWKAVTDCWNEIPATAVTEETFNIYMRAAIQCRKPEEVFNVYSKMMKMGVRPDVNTYGLLIEANGRMGNINEADKVFLDHFVPKRTDTNKMSFISRLLVKEPKNQFHTASAAPLLLHTIPPHSALTPTVNTFEALMDAHGRNNNIPGLHHIYKTMMPQYHIQPNLKIYDTLIKWYCRHGDTDAAQNVFIDMEQRGIKPTVTLFNHLFRYEALKKNRPKVAEALIDYMKTKYGIKPMPSMYTTLIKIHNKHNRENEASRLHEIYKQLKSNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2B3</accession>
    <name>A0A367K2B3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_011510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000373">
        <property type="protein sequence ID" value="RCH96392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2B3"/>
    <dbReference type="STRING" id="86630.A0A367K2B3"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000002">
        <property type="entry name" value="DNA polymerase delta small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="70"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="225"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH96392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="491" mass="55516" checksum="EBB3DD7850074DAF" modified="2018-11-07" version="1">MVALIFISEVQQLCSTEFKLSNQYHCPDNNFHSAPESSNDHIIERSISQFNKLERLNNQFLINKQTFDQQYASIYYLRLSKLRKAILNAAKERWSGLSEVPRYVAKVLDTQPHELCYMIGTVYIHMVKKPNILNDLEDEEAIIRPMVPTKYKSEEDVFSIEDETGRVEIIGACLNKEFLVTGMIIGILGKEAATGTFEVIDVCLPGIPDQSPLNSLQVSEKPKYVAILSGLNIGSDTCSEIQTQLLQEFLVGELESDLSPFITRVILAGNSISKPKQTKGADRFKRYVHDSSTFDASAVTQLDEFLEEVCSAVDLDIMPGQTDPAQVHLPQQRMHPAMFRQSHKLSTFHSVSNPYWCEIDNVKLLGTSGQNVDDIYRYVDSEDRMKMAESCLYWRHMAPSCPDTLWSYPFQDIDPFIIEECPHVYFIGNQPEYEDNLLLGPNGQKIRVVLIPSFSETGIVVLVNLSTLECHTVNISNHGKAKSSDPMDQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2C0</accession>
    <name>A0A367K2C0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_009336</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000380">
        <property type="protein sequence ID" value="RCH96310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2C0"/>
    <dbReference type="STRING" id="86630.A0A367K2C0"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="932"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1071"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1118"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1159"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH96310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1204" mass="139055" checksum="161E5D80B9C12CD4" modified="2018-11-07" version="1">MDEDQEICRVCRSESTPDHPLYHPCKCSGSIRFVHEDCLIEWLSHRAYKDTKTEKLTFSPCLNRYCELCEYPFQFSPIYRADMPEKVPLYVLCSQLIQRLMYLLKTLFRSIIVIFVWLVILPNFTLWTWRFYFWSGEHIGFNTIKTSNMTITSEDKVTSSVLKNFLSDCFEGQIITAFVVIIFVAAYLFREWVMQNLPADRNNNNFEPVVVQEQQQQNRDEQQLVQEQVAIDTLLNVVQVMNPPTPERRHDPENEYIQHLEHQLGGIRNEIENELNHRHHRHSTESAVHWLNHPEEEEEGENDRLNALFAGSSSRPSFMLDSDQHEPQEEGAPETGHDEFLPPFYQHRPEVLAGRDLNLDELDVRRDEEFHYRRHFQQMDNAIFERPRAPHNPIVPPPLPPPPPPAEDNEEPFEVADDINGVLEAIGMRGNPWMLVQNSVLMSLMISLCLGLAVWIPYVVGRLVIMIRPISFIETPIYILRFITDPLVDFVLDTCLPYAWSVIEVYWKQFVPEPIQVTVSSVYDELSKESPVLHAANGTSSQGLFDLTFIHTQLEETSKRALERWYQFALGQTVLDRSMCILVGYFVFICLGSWYLAHGRRRGSSRTAVQDVIRQQGIFLKVLFFIVIELVVFPTVCGFLLDLATLPLFVNASIESRYMFHLKSPYSSYFLHWFLGTGVLFYFAIFITVCREIIRPGVMWFIRDPNDPQFHPVQEMVERPLPNLLHKISQSALIYSVMLVFGVGTVTYSLAYTGVVFPLRLPFNKPLSTLAVDLLITQFLVPPLVQFMNPRENSKRALDLWWHFASRQLRLTSFMFNVRMPDEEGRHVRKTLKAWILREKATIPTDEFSDVGIDSDDNVVFKRDGMLMRVPKYDSVPVDPKRRMLVPVDPVTLEAIDEEERRRGHPAAADTGDESQSTIVVYVPPHFKLRTIIFLLFMWFSISLFVCSVTVVPLLVGRLLFKVYLAPQADVVNDLYSFALGLYLMMCIGYLAHWLYQSYVAYSARGNAQTEQCLAYIKEKGIKASRYIYLISTLAVIIPLLLGVSVDLFVFMPIRIHNSSGPIVINLSQDWAFGIVCMSIIYHTVLLLPTTNAVRQYMDQIFGNNMIQADLNLITRKVIAPVIITTLLAIITPGVISFCILYIMGTSRDPSYQLLVTRYTYPSIFCLMITTLLCLIFKKLFSIWIQTVRDDTYLIGKKLHNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2M7</accession>
    <name>A0A367K2M7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">STT4_3</name>
        <name evidence="10" type="ORF">CU097_013469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000371">
        <property type="protein sequence ID" value="RCH96416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K2M7"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1553"/>
            <end position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH96416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1864" mass="212127" checksum="E9F510102CD426F1" modified="2018-11-07" version="1">MITYYLVAGLLEIGSKCPQLYEEITSTLWAYAEFIIKLLPENVEFTVTFILPSLAGLTRALQLSPFLYRPAQLLNLCTNVQAMLQDDVLDMIRISITTCLRNADKSAYSRRVLAQYMNDGAPLSSNRIVHDLLVIFRNTLARILANAVPESSCTTPIVLTPKQCSKLYITKDIERIWTTLMQYSSKNHEVIDKGSEIDAQLKKCVKHLYVTSLGYHDDARKFAEKSDQEGAEWAPDAYMQEILGTSLQVAALSSVYLHEVDNSLTEQISECLFDTLKVPDSWVHIASLDAAVLLAMNFIHLNATMTDMLCRFLATPSSVFDLHKEKLKGSTSVQQHAITRLAQCVQTKFETHGIQTAISTVYALLNEITRYTQTNGEATYRAKESIISGAPAVEQLNEKQKQQVCANVLSAIVGIAVYIKDAEIISQAFSMLALRRKMLSPYAAASLTMKLVDLALVSSEKVFAEIISLLATINEEAIYVENNLLHTSIISAQLSLAERLKERPEYYQIYLHNILTLFIDIGNSIQRTMLKNKKEHEFPLESKLGSLLPVISALLEHADFNPHLSPTGETVALFRNLWFHCILFGFVTESIWIREWHNHMLKIARKTPVLVLESNTNYLESDLEHNSVLRNSSAAEHGLGPLRQKLNNFLPSLAYDIKNFSFAQIVFALSVYHVEMMRSRMGDCSHILHYFTNDGINTSTLANALETIAERVSQAFIKDASGKAQGQSLDDNLRSQVAALLKLCCHKRQKVHVMAIKTVERIVLSFTQVFTDGYLIQLLLELVQLTWLSCEAEYRDEYSPVFHFTSHRVKVTIELGDSYAYRKEVCTRLYQNARKWIQLALVRAPNEVSAHLQDYLSDFNKYATSGYSDVVHMGRSLALELGKTSSKSELAVDFVPNVPSVMPDESSNFLHEFRHKNFYLGQIRGMEYLISLREQAAHAENNQGLTSQVPIILEELESVLNDAVNKKSIPIERLHTIMHRSAAYAIAIPELNANIIRYLVRIPVYMFTPESIEIATSIWSWMLVERPEMESKLMIEVVNMWSWSQCYRKGMFSPLLNVKHPFASKMTYAPSDKAIRDTNHRVAAFLFTPHVTWIKFLSNRFYVFRHNSKHLVSLLISLLQSSFENAHLMCTHPLARYARFSLLQLGLKVLQSTRLEALAEYKFRTSLYHAAFDWFHQAPQWHYGARKSLALQEYRLLTDFYNTAMGDTPSLSFMITCASIIGGNNTKLATGHLTFLKDKSKDEVIKQHKNIHKLLLLFIESELTKLSVWSNPLNTVDPGNPVNFIGNTEKSMVSDDAWKEIIRVAWGISPKLAIQMDARFVQPIVRRELHRLVANNTLDVVDIPEALIILLGEKLSSNAKLDLRYLQYWAPVPAITAANYFLPAYGNHPLILQYAMRTLEYYPVDTVFFYVPQIVQALRYDALGYVEKYILKTGQSSQLFAHQIIWNMQANFYVDADKGCQKPDPLKPTLERIIEKLVASFTGEDRAFYEREFKFFGEVTAISGYLKEYIKHGQNEKKPLQKKRLDEELAKIKVDIGVYLPSNPDGHVLDIDRSSGRPLQSHAKAPFMATFLIEKEQEDAHHLALVKHQQQQQNELEIHRRTKQIWQAAIFKVGDDCRQDVLALQLIAVFKNIFTSVGLDLYVYPYRVVATAPGRGVIDVIPRSISRDQLGREKVNSLYDYFVAKYGGPDSIAFQRARLNFVQSVAAYSVISYLLQFKDRHNGNIMLDDDGHIIHIDFGFIFDIAPGGITFESSPFKLTAEMIQVMGGGSEEQAFRQFSELVIKAYLASRPYAELIMQLVTLMLQSGLPCFKGETIKRMRTRFQTDKNDRAAADFMLMRIKDSFANQRTVLYDYFQKLTNGIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3P8</accession>
    <name>A0A367K3P8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000338">
        <property type="protein sequence ID" value="RCH96769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3P8"/>
    <dbReference type="STRING" id="86630.A0A367K3P8"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="312" mass="36162" checksum="0722A9D2AE092A9A" modified="2018-11-07" version="1">MKTSTRSRSDASKIPRPMNSFMIYRLEKQREIVKECPGANHRDISKIIAKWWKEMSDEEKQPYRTKALMARHEHSQRYPDYKFCPQKKVKKTRTYKRRPKNEFTAIDFESRRQLIEIYHRPVKSGEDNSSPFVKKEADHDTNIVVWEAPNDEDKPKTTYSSCNYSHLHPYSSILDVSPSASPMSLTYSCAHSTMDGFCGNSDCGSPLSGKTLDHLDNRDRSSSPMELFLHNYSESDADHMMVVPGQAIAGDASFLSEPIDMCSPHYGQLVDYTTLMYPRWTHVTREQPLMVPTYFFTTSQPVYPLCFDQTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K441</accession>
    <name>A0A367K441_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000324">
        <property type="protein sequence ID" value="RCH96930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K441"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="80" mass="9212" checksum="053BC010B65F19FB" modified="2018-11-07" version="1">MVVTKPYPCYLFSLLTTNPPTLHHDNFINKPNIFYLHSPVAQSFMESSFDQTIRLHHNNELSSAVSCNYHRKITDHPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4C7</accession>
    <name>A0A367K4C7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000317">
        <property type="protein sequence ID" value="RCH96996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4C7"/>
    <dbReference type="STRING" id="86630.A0A367K4C7"/>
    <dbReference type="OrthoDB" id="2354504at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="60862" checksum="EB9AB7F0AB755194" modified="2018-11-07" version="1">MNYSDIFLIQSPKSPNENIWYYTPEQLRNRQCEFIERPSPIDTVYNSPTAEADYMDLIKNRIVIEFSTFSELKLALIDSEDTNTSNVVKQTEEEEMRIQTTSTTIPSSVRTDVESSHLLDVLMDQATQHWCCIGFKIAPIKLEMIKNWRQAPWPIVYCVASISLVSFLNRQHLSDFNRHVAMAFYQQARAKMDDILEDSMSPQIIQSYFCLSYTSNLLRLYEHQRTWGGLASISLQHLVKSNSAQIDPATLSLWIRWYYIDAWLCLTAGRDCLLPDRLPWLDLKTIEQLSISQVVQADDNQQFGFACIGYYMRKYIRAIQAGKLYNTHPYEPSTYYYQITDSLTRWYSQLPTYSSNSPASRLHLHICYHSMRLVVLYHFLQQPQQPSPESILIDCLTTNLELLQTLEHLKQRGCDQSTYHHMFLAIHNTSKRIFQYKQLHALRSFAEEQLKINLALLKGTQAYTHDAFKMKIYAEMIQNQLDKMNISMEKKQNVMPQILVFKKDASISTKKALKNKRIKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K572</accession>
    <name>A0A367K572_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000289">
        <property type="protein sequence ID" value="RCH97295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K572"/>
    <dbReference type="STRING" id="86630.A0A367K572"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="82592" checksum="4397976ED8C35A4D" modified="2018-11-07" version="1">MFLFDASENNPYQPGSSRSKKAKSKAKSAEAKAVAKAKKMQQDDMESLQITFYEIESWIEKTSPVLARMTKELDRVSKHFNKDKKKNEQQKIPIDLSSMQWTLTFQPNNSMRLETNIKSVEQLIDAVQKIKLITDSDSSIQQPDEEDFDPTFSSSASLSSSSTAVTDSSSEYWTLALCRTPGVCFDKYQSRLLELDRLSEQVSSDVLAFACQTYWDCLFPKFSTDWSTFWDRSGDPQRNQICIDAGLAMVFTHIVRHSKEICPDGYAISYYYYERARQSLMDYFDSPDAATIEALLNLAMFCMLFKHYSNTRIYLDLAFRMTVQLGYHRRSGLPTCKLMRKQWIRLFLTLCYNDMALSTYSNGSFLVDDTVHDIDFYELITLNNELPHLDERTKIKDTYFVHLMELMKIHKRIQQMTKEYQDQHTQYHYSGTLPPRWIKKVQALEIALATWLDRLPLEYHLDPRPDDQLRSDTTDIEKLKEQSALLLMLHYQMQWIALHKVFLSTNLIPIDLKEDPTTYRTHRSYAICTDAASRILVMAEIFTNRFHWCVCQLFISCIYQASTVFCKSVLTKDHRADESKAMIRRVISILAANNLNYGGLPEDLRACLNEFLQENTNDLQVIDQTLSQESISQPITYNDAFYNSPHMYKQCINQRLHYQSSSSPSPRTLYQVPTLLPLGMQTPTVHVEDLDIKSTNWRCKFSSSNYAQNHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6U0</accession>
    <name>A0A367K6U0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Stress-responsive transcription factor hsf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HSF1_4</name>
        <name evidence="10" type="ORF">CU097_014837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000234">
        <property type="protein sequence ID" value="RCH97972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6U0"/>
    <dbReference type="STRING" id="86630.A0A367K6U0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="106"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="649" mass="72417" checksum="F9521901C7AFB44A" modified="2018-11-07" version="1">MKKPQPQPIQKLRPNEQQPLTRKRSHSASSSASSDSPGAFSNTFSDSGSSSMTSNASGHMKRTRSVHNVDPSSSGDSSNISSSSSAPQTGRNSSSSNNQRLTAQRSVPAFLNKLYNMVSDASTDSLIRWSTDGNSFIVERHEEFAKKVLPRFYKHNTFASFVRQLNMYDFHKIPHLQQGVLISDSNSHEIWEFSNPHFQRGRPDLLILVTRKKNKDRDNMDGDAPSIASLADDLALIKKHQETIGNQLKELHRDNEILWQETLNSREKYHRHQEAIEKILLFLTAVFTNNDQLALPMGSNGTDVLLKGLIEEAASLAGITIDQDKVNDIKLSSTSLGPATLTNILSSVLKLYSINQSDQPPQQIKPDIDFTPTVAPSSIEELKPPSLADFSQTLNTATRSAQSITQDISMLQMNIESLANNLGIDPNQFDEDMETDQVPTNYAWNPESYDIANDSIIIQKEPEEIITPPVMTAAIPPKLNLQFPDAGHPEEQQRNKQSQQIFQTQASKSHLKPQEKYIPQRTPYSIPADNHTSSVTDIKSMNIGYQQFISSMNALNSHHSNTNDIPGYISAPTTSAAGTSTRVSPIINDPHRTVNTRYFANDVNTIDQQTTTPIQPQPQQHRQLDAYGFVNLQNNYASNIPEQPFYNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8D2</accession>
    <name>A0A367K8D2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_007371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000196">
        <property type="protein sequence ID" value="RCH98445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8D2"/>
    <dbReference type="STRING" id="86630.A0A367K8D2"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH98445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="554" mass="63097" checksum="2F5CA373EC0C2A1A" modified="2018-11-07" version="1">METNFIFSNHHSASLEMPLVAQLQSEVPFEMAPTYNSNNSVPPIETVAYGQPYVPHITTTPVVKSHNIMYQQQHQQQDQNLTFIDNNMTTSTTMDVDYFDHVTAVTSNHGNMVAMDPTFNNMQSIYSPSMNSVTTNSSVMMMDTLSPISPINMMSPTAHLMSHGNNPMDTFVAPVNVSYMMTGDNISNNNGYFHHVVAQPATVESQNYLDRKAKRSLPRRHTVSTPYDTNTSTIEKSNEAKATVTAASKKSSLKAKRHRSMGKLDIYAQQQDNIPPVPNIKELSNKLEHWTHQELLQRVIELEKEKKVAASVAQIANEGGVMMNSNTHVSQKGLDKVRSNSQTDNEEEDDEEDIEEEEEGGSTEEEQEEQPQKCQWEDCDEEFNKLEELTNHVKADHIGSGKTQYYCLWKECPRQQKPFTKRHKMHNHLRTHTGERPFICTHPDCGKKFSRPDSLTTHVKIHSNIRPYLCKQPNCDKAYYHLRSLRKHEKTHMNNNDNNNDSNNNSNNNKHQVVQSATSQLDNMSTAMVEQDIYSDWALSTQAAVFDVMETYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8I4</accession>
    <name>A0A367K8I4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000197">
        <property type="protein sequence ID" value="RCH98439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8I4"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="109" mass="11926" checksum="F74CF297808C9560" modified="2018-11-07" version="1">MSAGDYRPNRSTLCSTKSLGSLQEMVSFKGIPENYIALKIIMATQYWDFLVLGQCMTPLNGTPCNHTSCYLFKGPSAPPLWIPPVGVNLTDLSKLLPLSALSSKLPIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9T6</accession>
    <name>A0A367K9T6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar transporter chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VTC4_16</name>
        <name evidence="9" type="ORF">CU097_014300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000161">
        <property type="protein sequence ID" value="RCH98910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9T6"/>
    <dbReference type="STRING" id="86630.A0A367K9T6"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH98910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="741" mass="86248" checksum="F020D1ABE59A2CA8" modified="2018-11-07" version="1">MKFGDNLKGKIHVPWESFYIEYNELKHEMKRRQMEHGWNATDEAEYRQKIENELIKVHRFIDNSLGDLNKRILHTEVMIRELMMSAEAKQRYDDIADTLTEILFDCNDLSKFLCLNATGFDKLNKKHDKHTRIEFSGVFRKELLSRYSLDRLSLQVDILIVKISELIDICRLHGNPRNTQDKNLDDQTAFERATAKFWIHPDYITEVKSVILFHLPVHVFNQKKQYEEGDMAVSSVYFDNKQFDLYLGRVEREAGAEAIRLRWYGDNEDDVYVERKTHKAAWLDGKSVKDRFKLKQTLINDYLAGRYTADDLVEDLRTKANGKARSEAILEENHFVASGIQESVKTKELEPMCRVFYNRTAFQLPGDQRLRISIDSNLTFIREDGSERRQLIGPKQLHWKRKDVGIDYPFNHVAENDISRFPYAILETKLQTHLGQECPAWLTALLDSHLVFEAPRFSKYIHGAATLFKDSVPIQPFWMQEFDKDIRRKPTGNYGLSRSQSFKPLVNGHHRASLLLLYEREMQRSARKKNRSLINLFSINGSFKKRNAKQDQPQQDPSSKPGQPVSPTHMTIDVSDVTMSKTYKDFVNRFQNLSTPILTGSFLKRGRSNKRASPLLPRARSSQLVKKAEPKTFFANERTFISWLQFCALLLTVALNLLNYGDLISRGIGATFIIIGAALCIYALVRYQIRSWQLRTNQNLIRYDDIWGPTVLCILLVVALIVNFYLRFETLSPSYHQKPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA12</accession>
    <name>A0A367KA12_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000152">
        <property type="protein sequence ID" value="RCH99028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA12"/>
    <dbReference type="STRING" id="86630.A0A367KA12"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="306"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="396"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH99028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="502" mass="54946" checksum="974DC330E4DE92B9" modified="2018-11-07" version="1">MKRSQDTQEANDTKKPRLNQANYNNNSDPYAQYSLLSQYGTAFAQNGVTVGGYGQPASMYGLGYGNASMVAPYGYPPAFFNPAAAAAAAYSGVLGEGNRTIYLGGVPPNTPPGDILKQIKSGAIEQYKALPEKACVFITFVDASAAHMFYQELMLKKLTVNGQELKYGWGNSTSMSLSLKLQIQSGATRSVYIGRYDEQQVPKEQLASEVTKFGQIEDIKVVPDKHCAFIHFLSISSAIKCVSELPNQPNFHNKRINYAKDHCASNYSPDVLASNPSPSFGFDAYGNPVMNPINLNTSPTANNILRTLYIGNIQSEAKVEDICNSIRGGNVLQVRYFPEKHIAFVSFMDAATAIAVFNYANSQGIAIKGRKVKVGWGKPSAIPTQLMHAIQQGATRNVYIGGIEDVSEEKLRQDFESFGEIELVNIFNEKKCAFVNFTSVQSAVMAVTTVKQKNPFYQSLKINYGKDRCANPPRIRSNKGDAEPKLGIAAEPANQPEQQQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA14</accession>
    <name>A0A367KA14_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease 3'-5' domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EXD2_2</name>
        <name evidence="2" type="ORF">CU097_009482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000156">
        <property type="protein sequence ID" value="RCH98969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA14"/>
    <dbReference type="STRING" id="86630.A0A367KA14"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="282" mass="33301" checksum="E9C5AA6DDD4A4343" modified="2018-11-07" version="1">MPREKKEIVMPSKKSNIFYENWKVYSRQHKLMFRCNEKKAQWYLKRNLANIIDNEPKAIALNFEAKGSGHREGDYMVQDRSNVCVGCGQNEHLTVHHVVPEMYRHWMPLVIKSKSSRDLLLLCKQCHTKYEADATLLKKQYAKRFDIPLEGKGWVNLPEHRKARKAASALIHAADKIPQERQAVLETIVRDFWKKHHDESVNRETMLKRCSELEDFYKGPDFIEHGQGVIGQLMERHIVEGGLSFWPDLENFIKEWRQHFIDHLKPTHLSELWTVDGDIYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC06</accession>
    <name>A0A367KC06_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000105">
        <property type="protein sequence ID" value="RCH99708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC06"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016644813" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11479" checksum="888EE7A298B29115" modified="2018-11-07" version="1">MQIKLVILTICAFLAATGFALPAPQMQPASNPVPGGEIAHSAFDANGAPEDINESVGAISLDDFTDMQDEESNPDTEETLLQRSPLFSLAYIARKRIRPRPTKPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCR4</accession>
    <name>A0A367KCR4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_002624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000086">
        <property type="protein sequence ID" value="RCH99995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCR4"/>
    <dbReference type="STRING" id="86630.A0A367KCR4"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH99995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="337" mass="35871" checksum="F67B2AB3063A4791" modified="2018-11-07" version="1" fragment="single">NMGKKRKTKQIRPWCWYCEKDFEDDKVLVTHQRAKHFKCEVCSKKLTTAGGMVVHAQQVHKIEIYKVPNALPGRDNLDIEIFGMEGIPEEDLVAHELKVAGLNNSKKAKTSTGGSGQYSELTLEEIQAQMAAHKATANPNLTTTTTSNTTTSAAPTSATITAAPAKPATATVAAAPPQYYYGQPYGDYYSQYYANYYGAPGGYPYGYPQAPYPTTEYPAYGTMPVPGAPPMPPTGMAPPVPNTSALSDATQANTTSTATPTSSSPPPQPQAAAVPSTTTATTTTTTTTTTTTVETSPPSGKETQNTTTDSTTGLTTTKKKATKVVLIFNNQDYSAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDA9</accession>
    <name>A0A367KDA9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000079">
        <property type="protein sequence ID" value="RCI00131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDA9"/>
    <dbReference type="STRING" id="86630.A0A367KDA9"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="170" mass="19576" checksum="1C912A0338E1FEB3" modified="2018-11-07" version="1">MDVKNLLNDTVELYEKRDFDYGYASPSMSWSSASSISSSDTVPSSPIAFPGKPKEQQQQTRIPWTVAEDYLLQKGYLQGLSWAMISAKYLPHRSRGCCWGRFKTLRAKSSQRKGWSVNEDRILLSSIKKNTHLFKQAWRSVALDLNNRDWKECELRSACINLINHQVEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDR6</accession>
    <name>A0A367KDR6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000064">
        <property type="protein sequence ID" value="RCI00373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDR6"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="225" mass="25796" checksum="308B25BD3044F582" modified="2018-11-07" version="1">MGAQTSKVARKLPTKARPETLQSAPKESPATLKAQTEAAAEIKTDFIEQDGRDPHLHEHLKSIGPVTIAPTVTKMRTSDPMLGILRERKKADEKELERQDGTISIDAVFSLLEERKHLNPGEEDLSETRQRWTEKYNVDQNTLSTLLKYYNTMAITPVLADEKEGRRLGLWVKDRVDWEAKVRQVEERNAAIEKAKQEAIKDNKKQNVDISEEEKKLRDLFDEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE34</accession>
    <name>A0A367KE34_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_001059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000080">
        <property type="protein sequence ID" value="RCI00102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE34"/>
    <dbReference type="STRING" id="86630.A0A367KE34"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI00102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="408" mass="45833" checksum="779D9683DDDD7DE8" modified="2018-11-07" version="1" fragment="single">MLNSPRNSVAHNQQAKLAVDYNELLKELSSHEITSVGCYTIGETIGEGTFGKVKKGYHKLTGKVVAIKKISKQHAPMMAREIHHHKQIKHPNVVMLYEMITTESAIHIISEYCPNGDLLDALTLSGGRCSEARVHKWFHQLTDAINYCHMHHIVHRDLKLENILLDADDNVKICDFGFARYIQKNQYLETFCGSLSYSAPEVILRKKYTGPETDIWSLGVILYTLLAGEFPFDDDSEVVTQRKIVQVDYQMPYYFSSKLSSLINGMLQLEPSNRFSLDTIINHPWMTEIEDDMIDQGLTPSSSTTSNNSTSTDIDLIVENVPTSPQFIFSPQIKSSLGLTEKSPRFSAPTLNNNRYSSTSPSSFRTSLPSSFAQQKPQGMTPVEQRLFAALTAAGFDRDALIKMQTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEF6</accession>
    <name>A0A367KEF6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LAP1_2</name>
        <name evidence="11" type="ORF">CU097_015524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01000053">
        <property type="protein sequence ID" value="RCI00568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEF6"/>
    <dbReference type="STRING" id="86630.A0A367KEF6"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016484210" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="164"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI00568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="378" mass="42468" checksum="9924662CFEE442E6" modified="2018-11-07" version="1">MKLISLSFLSLSALAALVNASPLIDQIRIFDVPEPQRRLIQYSDDVPPKWMTESDKSALLRAGIKFMDITDHPNTPVTSFAAEIPAIPTKAIYQQEAEPFIGNLTTDTMETVLTHFTSFRNRYYKSKYGAESCRWLIQQIRDIASGNDHVSVKEFKHSWDQFSIIARFEGSSKDLENEVVIVGAHQDSVNMWLPSFGRSPGADDDGSGTVTILEAFRSLVHNGFKPERPVEFHWYSGEEAGLLGSQDVADKYYQDGKRVVAMLQNDMTGFIGKNKDKEVIGIVTDHVDEKLTDFLKALVDTYAAIPYSLTECGYACSDHASWRKLGFPSAFTIESEFDNSNPYIHTTRDVIENLSFDHMKEFAKVAVGFAVELSHVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGN5</accession>
    <name>A0A367KGN5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGN5"/>
    <dbReference type="STRING" id="86630.A0A367KGN5"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF58">
        <property type="entry name" value="METHYLESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016570999" description="pectinesterase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI01384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="332" mass="36117" checksum="B4EE2E093FF4733D" modified="2018-11-07" version="1">MQLFLGYLTLALLCIQLVSAGTISVCNSCQYKSISKAIASLPNNAESYTVLIAPGTYTEQFTIARSNLVLKPASGTVTIQYASGHDTSSKTGSTADSAVLTITGKNVMLQDIVIANTLKQTHVANVALHVNAPQAYFKNVKIYGFQDTLLINRSGSAYFKNCWIEGSVDFIWGFGTGYFDKCVIASNQKGTSVTAHGRDTPSGPGGFYFNHCVFKATVPSGPLSKTYNPSMAFTSPAQFPDTCFFARPWGKYSRVIIMNSDIGNHIKPAGWSGWSDANPNTANVVYGEYKSFGARPWTNARARFAKNLSDSQVAQYSAKKIFNGDVTWFKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH38</accession>
    <name>A0A367KH38_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prostaglandin E synthase 3 (Cytosolic)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PTGES3</name>
        <name evidence="4" type="ORF">CU097_013499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000009">
        <property type="protein sequence ID" value="RCI01450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH38"/>
    <dbReference type="STRING" id="86630.A0A367KH38"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI01450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="166" mass="19287" checksum="D3D80EC543FCE8C7" modified="2018-11-07" version="1">MSLHPTVLWAERNDLLYLTVDLSDIKDQKVDLTETKLSFKAKGGVEQKEYAFDIEFLKPVKVEDAKQHLTPRNLFLVIYKKEEGYWNKISKDRLRFVQTDFQRWKDEDDEEEDMGDPMGGLDFQSLMAQAGSSGGLPNMDDLPEGDDSDDEFEEDEQKEVQEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHA0</accession>
    <name>A0A367KHA0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UAP1_2</name>
        <name evidence="7" type="ORF">CU097_014927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000005">
        <property type="protein sequence ID" value="RCI01548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHA0"/>
    <dbReference type="STRING" id="86630.A0A367KHA0"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="500" mass="55280" checksum="32D8C433BC83E0C8" modified="2018-11-07" version="1">MTISSLLPVNEIELQALKERYDSAGQGHVFQFFDTLEVEQQAKLIQQLLELDVERLNNIYRKAIEGAEAALLSQAAALEPLPEAIFDSVVKATPEQLREWETIGLTQIAQGKVAVILMAGGQGTRLGSSDPKGCYNINLPSQKSLFQLQAERILRLQEIARQYTKPGAECIIPWYIMTSGPTHQPTVDFFEQHNYFGLKKENVIFFQQGTLPCLTMDGKIILEAKDKVAIAPDGNGGIYAAVVNRGVINSLKERGILYSHCYCVDNCLARVADPVFIGYSVSKGTDCGVKVVSKAAPEEPVGVVCVRDGKYGVVEYSEISQEISEKRREDGSLAFGAANIANHFFSTEFLERVPTFADQLEYHIAKKKIKYVDLETGEVVVPKSNSGMKLECFVFDVFPYAQHFSVLEVDRKEEFSPLKNAPGSGADCPETSRRDIVAQHVRFIESAGGKVVHDGDFEKLQFEISPWVSYSGEGLAEYVAGKTISTPAIIETKADLIRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHY6</accession>
    <name>A0A367KHY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_015948</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01000009">
        <property type="protein sequence ID" value="RCI01462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHY6"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI01462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="792" mass="89574" checksum="9EDC2E32DBB49A4A" modified="2018-11-07" version="1">MSTSPSLQRKNTPPLLPGILRITVNSCFLNIPVKRPYVVITLGDQIHRTSISEYPQGYWNEGFELKVTYHNQLFDTIQLDLYDSNVFFLDKHIGRAEIRLRNLEGMPESFTSYYEVFEKRLAIGAMSQVSRKTLMTSGVGAIQAQIAYLYHRSPEELYHTSIDVNEMNYLIDKQQKELEYENKFSDRELIEEFNRRLKTQRESNDEIKFNKYEQGQDSVDDGQDFPDDSGTEEEQQKQQYQPERPLSLSRSRASTISNVAQEIEPATSNNGSFLNSITSLFGFSSNTEKTSTQTTNNRSTTTTTKTTTTTVSHYEDLEKNILKDEDDGLKSFPLLNTIGSWAMAKETNQVLRAIAKLLVAFGQGFELSNLQILAGFTVVEKFYTDLPRDRTWDTVQDASEIEMASYMWRYAMASYGWKGLNFIGKGNGIFSDAVRAQSDALSICEHLNLNKEDLLAYELRTGAAFRPSYFIARDRKLNAIVLSIRGTMSTFDTMTDLVCEYEPWKGGLVHKGMKSSAAWFFRNVAPKLIAYVNKHSTTSLYIVGHSLGAATGAILTIMLSDYLNEFRKGKDRDFNIQCFGYAPACGLSLDLANRYKDRITSIVFADDFVSKLSYGSMMDVKELILAGAEAAKNIGIGQLFWASETNSEVWRDAFKRISECRKRCLESMSNPRLYVAGTVYQFWLDPIPNNESRIVIERTTPEKVSTELIIKKSILLDHLPTNFDVAFTRALDSLNVKPTDQLTMDQQQEREDMRQQKSAQDKLFGSIAEAGIKGTTGRGGGEGNVVGQGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJ90</accession>
    <name>A0A367IJ90_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005702">
        <property type="protein sequence ID" value="RCH77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJ90"/>
    <dbReference type="STRING" id="86630.A0A367IJ90"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="93" mass="10424" checksum="3FF0E9FD5A4EC81D" modified="2018-11-07" version="1" fragment="single">KYSSLANGSLLETTTVNGLTSTRWELTYPCPSYLICFAVGDFISVDDEEVNGIPIKVSISYFTSTKYKAEDLKRTFDKTPSMIKWIQKKVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN94</accession>
    <name>A0A367IN94_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004787">
        <property type="protein sequence ID" value="RCH78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN94"/>
    <dbReference type="OrthoDB" id="10043543at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10463" checksum="A146C258A347E4C5" modified="2018-11-07" version="1">MFANAPPITWVDQSGQEQSSPRLIFVWEHVKMFRTYCYILTFAWSVILMGEFAAKVIMIKSTLDVDHIVLYGNIIIITMSIGGTCSRMDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPZ8</accession>
    <name>A0A367IPZ8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004414">
        <property type="protein sequence ID" value="RCH79571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPZ8"/>
    <dbReference type="STRING" id="86630.A0A367IPZ8"/>
    <dbReference type="OrthoDB" id="2236709at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="82" mass="9394" checksum="E68FD81F7CB5A5E1" modified="2018-11-07" version="1" fragment="single">MSDKGNAVNDLQDATKKMLPKHFKSIYEATRIALDLKTIETKLNNLSQIRERLSRESKAPESLKSMDDAMKDIENEINSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRS2</accession>
    <name>A0A367IRS2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003962">
        <property type="protein sequence ID" value="RCH80352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRS2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH80352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="94" mass="10351" checksum="E2308D9C1A2540C5" modified="2018-11-07" version="1" fragment="single">IFISKGTIKVDDAPGTLLSDVLDIDQHYDSAGPFKQHHLDSTKAQAQSNLLGHSEVTRFKFKTMSGDVDLDIDLGDIEKPSVQAKVLKPVKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUB1</accession>
    <name>A0A367IUB1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SUB8_1</name>
        <name evidence="10" type="ORF">CU097_002789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003500">
        <property type="protein sequence ID" value="RCH81295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUB1"/>
    <dbReference type="STRING" id="86630.A0A367IUB1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016769381" evidence="7">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="47"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="168"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH81295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="432" mass="46242" checksum="D3D01787CE963BB6" modified="2018-11-07" version="1">MKLTFLTAALVLAGYATAVPMVKTSSFDDGYVAPLYTPVEAEAVRGSYIVVLKDHLSMEQLQDHAEWISSMVAAKAYNNGEFLDSSFQMGIKHVYETPNFKGYAGRFDKNMLEAIRRSEEVDFVEEDSIVYASELQRGAPWGLARISSRKALTLRNFSKYNYDANTAGDGIKVYVIDTGINVSHNDFGGRATWGKTIPAGDDDRDGNGHGSHCAGTIAGTKYGVAKKARPVAVKVLASNGSGSMSDVMGGVDWAILDFRKDKEQAQTEGKPFKGAVANMSLGGGKSVGLDKIVNAAVDAGMVFAVAAGNDNRDACDYSPARAEKAITVGASTIADERAYFSNYGKCVDVFAPGLDIQSIWIGSNTATNTISGTSMASPHVAGLAAYFLSQSEPGVTPKEIKERILAVATPNELKKIPKDTPNLLIYNDYEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVB6</accession>
    <name>A0A367IVB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003357">
        <property type="protein sequence ID" value="RCH81617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVB6"/>
    <dbReference type="OrthoDB" id="2234771at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="341" mass="38302" checksum="2B1CAF5BF58B9F70" modified="2018-11-07" version="1">MQVDSYEQYADELLSRVFENAKQNQSLSSPISDWSASPLLCKSIDQTPILSPSLSNRSIENAFSPVIKSPQSDLVSGRHVDVSSMDSKSIILPPAPTSPIPPSLPSSPIKQQKNFLHDTLSRKLSRKKKEFKSVKKPLKAPLVKSNPSQEPLEPSQEQQERPQIQRQPSFWKPREDRPNEWWKSKKGQGEQSLKQHKVASIRAKKPKRPMAFKTPKRKPVAHTEKKKASTQSHRPGTVIIKRVPQKQAISTDASISSNETIAVAPVSATMPQPVYMVQQPYAMIPPVNHAGYYLVPSMMMPAQPQQPQIVSDKPKPQQVKRKKVTTLHNPREASNDKCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVS0</accession>
    <name>A0A367IVS0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003313">
        <property type="protein sequence ID" value="RCH81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVS0"/>
    <dbReference type="STRING" id="86630.A0A367IVS0"/>
    <dbReference type="OrthoDB" id="3514033at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.210">
        <property type="entry name" value="Stc1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043069">
        <property type="entry name" value="Stc1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="14208" checksum="C6F889A43F707301" modified="2018-11-07" version="1" fragment="single">PHSATNANNNQRLQKLRCVFCNTDKPLDAFSQTQISKATFNPYAPHSYNKKPKQVTCKTCTSRQNTHLTCMMCNKRQPLDKFAKSQRRNAEKARCRKCIEKREKEDVWASDPDTDSDDEYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IW26</accession>
    <name>A0A367IW26_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_000228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003233">
        <property type="protein sequence ID" value="RCH81900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IW26"/>
    <dbReference type="STRING" id="86630.A0A367IW26"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="32"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH81900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="277" mass="30889" checksum="C884E958F98B49A5" modified="2018-11-07" version="1" fragment="single">MSYSTKIQPAKRVSTFSRDVWSIFTPLAVETKAINLGQGFMNFSPAHVVQTACKQAIDKVESNQYSHPKGLLRLRNALAASYKSQFNGRELDPETNIIVTAGANEGIFATLAGFLDEGDEVVVIEPFFDQYIPNITMNGGVPVYVPLRPPTDADQRVVSSHEWTLDIKELESKITNKTKIIIINTPHNPVGKVFSEQELNAIGQVAEKHNLLIISDEVYDRLYYPPYERIPRIGNQFWNRTITVGSGGKSFAATGWRVGWLIGPAELIQHAYAAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXH1</accession>
    <name>A0A367IXH1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rax2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003039">
        <property type="protein sequence ID" value="RCH82367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXH1"/>
    <dbReference type="STRING" id="86630.A0A367IXH1"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="50571" checksum="99A3DE808153E7D3" modified="2018-11-07" version="1" fragment="single">WRGVEGSDWKGTIYSMVAHQDILYVGGESLGQAGKAFVAFGLTNGSLILSPNITTSDGSNASVSIVRSVPAQNAIIVGGHFSLVGELGCSTVCALSTRNHQWLPLGSGLAGQVTDIEYIDGKLVATGNMTLNNSPITIAEYDFEKQVWGPFATANLPGPSVAMTYDNVTKHTFISGKDSTNGSTYLRVWNGQQFNPIDQGLGSGSIISRMYSLPVKNTTQNTLLATGLINLGSLGNVSAAFFDGQQWTPYLVTSSASTDGFLRSLFYFDIPSIPSTIRRFLPAPLVILVSIAISLGIVFLIVLATMCIIFFKRKAESKIDPQNAPEAYYSKPPRSADSVLAALKDENNNNPNYSAEKLDTLEPEAQIYSMSRSISTDYLHEQPPTPAMMKPTALSPAPPKVPYNMSTNSFYQGLTPSPRPDSFVRPMSDIRRDSQPSSMTVREMSEVDDDRRGSYNPFRRPSSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYH5</accession>
    <name>A0A367IYH5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_004210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002912">
        <property type="protein sequence ID" value="RCH82740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYH5"/>
    <dbReference type="STRING" id="86630.A0A367IYH5"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH82740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="348" mass="37932" checksum="F9527FE6A20D4E31" modified="2018-11-07" version="1">MSNNDTLTGWACAGKGKPLEQMQFPMKTWDENTVEMDITHCGVCGSDIHTIDSGWGPTDYPVVVGHEITGVVTRVGKNVTRVKVGDRAGMGALCGACGQCHRCNQGAENTCLKGGVATYNSHWPTGEKTFGGYADKWRGDELLVCKIPDNVSNENAASFLCGGVTTYAPLRRWKVGPGSTLGVLGIGGLGHFAVMFGKALGANVIALSSSNRKREDAIKLGCDDYVVTSNDEEMAKYANKLTHIICTGVGEDFKWETYFNLLLPDGVFINVNAPEFQYPPVPIFPQLMKQIVVTGSLVGGTKDLDDMLQLISEKNLKAWYKKYPMSEVNKAIEDFRAGLPRFRFVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0K5</accession>
    <name>A0A367J0K5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="9">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UTP25</name>
        <name evidence="13" type="ORF">CU097_004065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
            <location evidence="2 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002653">
        <property type="protein sequence ID" value="RCH83464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0K5"/>
    <dbReference type="STRING" id="86630.A0A367J0K5"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="12">
        <location>
            <begin position="333"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="11">
        <location>
            <begin position="605"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH83464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="795" mass="92890" checksum="3642F6A9EFC3DF57" modified="2018-11-07" version="1">MAKERSAISKSMKKRVSGTHVSGLSTSKSTKKKESGLKFGQLSRKQKQDLQDYGELVPKDFEEEEEEEGKTVKRRRVVTEEELDRELEEEKKIRETQFESEEEESADEEEEGYKKPSAYSLLIGSLKKTSKQKDFYKKIQLEEEGFDNEKEQLALQEEEMDEDDMLDEEAVDDEDIDDEDIADEEDEDEEENDVKEEEEVDADAPDAYEEEEIIYAGSGEEEEEEDDDALAQDIYEAKYADQQSGLLDEKIAAVEQKKWVPHAFKDEQLSEVVALMTDNEKISMNAPKIEKLQDIRVKKRVADAWPKTNKSVKKGRALFTPLQNSLFYQMNQYRDILYCNRTLDNAKEIRNTYVLHALNHITKTRDRVLKNNAKLVKAQKEGNDVGECRDQGFTRPKVLILLPFRNTVVDVVDSFIKLSATEQQENKNRFYEQYNLREEEDLDPTKPIDFLQNFQGNIDDHFRLGIKFAKKSMKLYADFYNADVIIASPLGLRTLIGAEGDKKRDFDYLSSIEVVILDQTNHFLMQNWEHIEHIFQHMNLIPKESHGCDISRIKSWYLDGKAKYFRQTMLFADFLTPEFNALFNKHFKNVSGKLKIKRTYEEGSILDIIPQIQQTFTRIESPSLSSIHDARYKYFIEKTLPALRKSAIMQSHTLIFIPSYFDFVRVRNYFEDNRYSYEACSEYASGPQITRARAQFFHGRCDFLLYTERLHFFRRYNIRGTFHIVFYGLPEDPLYYTEVVNFLALKFNEASAAEEATFSCTALFSKYDFLKLERIVGTERAKKMCTAQKNVFMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J197</accession>
    <name>A0A367J197_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_000425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01002577">
        <property type="protein sequence ID" value="RCH83714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J197"/>
    <dbReference type="STRING" id="86630.A0A367J197"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="5"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="23599" checksum="4AABFC16647E1EA4" modified="2018-11-07" version="1" fragment="single">RITLIRGNHESRNVTRVYGFYDECMAKYQNSKVWEWCCMVFDYLPLAAIIDGSVFCVHGGLSPELPSIDSIRTLFRMQELPQSGGHCDLLWSDPEVQVETWTISPRGGGYLFGPLPTTAFCHNNKIDLIVRSHQLVDEGYNYPFLEKNLVTLWSAPNYCYRCGNKAAILEVPEENRKIMPSDYKIFLENDIQGENTLTAGPGSQYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1H5</accession>
    <name>A0A367J1H5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZTA1_1</name>
        <name evidence="6" type="ORF">CU097_003501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002555">
        <property type="protein sequence ID" value="RCH83785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1H5"/>
    <dbReference type="STRING" id="86630.A0A367J1H5"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="42"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="382" mass="41734" checksum="4D10880C77D1B5C5" modified="2018-11-07" version="1">MLLRSITPTFFFTARSTRSLLILRSMSSIPSTMKSVFIKEHGGVEKLIYDDIPVPKVSEDSILVKNHFAGINFIDTYQRSGLYQVPLPHILGKEGAGEVVQVGSGVKDYKVGDRVVYLGDSTYAEYTNVSTSMAQKLTDDVSFEEAAAVSLQGLTALTLVRVAYQVQKGDIVLVHAAAGGVGLLLCQMLRHLGATVIGTVSTEEKAKLARENGADHIIIYTKEDVVERVNALTDGQGCHVVFDSVGKDTWEASLAVTRRLGSLISFGNASGPVPPISVLCLMPKNLRLMRTQLFPFIATKEEANKWWGELMDLLSKKIIKIHIHKHYDLKDAHQAHTDIQSRKTTGKLLLKINATADEAANYDRAYSYSASAIPLTTSVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2N9</accession>
    <name>A0A367J2N9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002442">
        <property type="protein sequence ID" value="RCH84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2N9"/>
    <dbReference type="STRING" id="86630.A0A367J2N9"/>
    <dbReference type="OrthoDB" id="2282220at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="241" mass="28041" checksum="D0ACD58CC16DAB7A" modified="2018-11-07" version="1" fragment="single">IISTLRQAEPLVIPETLLPDNTQLIPRLTEFINESITPIRNRLPVIHLDKATLSVNPQDIILVFRIQELAALANEEGRMFLNSIYTAGYTCRVSFAKRKNENRLEAVKFQLHDLNNEEIDNHFRACTVGPGRRDAFNSYHGGDDFRRLTTVEYYNASDSPGRMCKEDNRKIRNGLKEIETDVPTVKTANVEQFTRHIQYIFTNLDAFFNFYDFTVAEITWKNHRGIQKIAGCLFKYFDQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3I1</accession>
    <name>A0A367J3I1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002349">
        <property type="protein sequence ID" value="RCH84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3I1"/>
    <dbReference type="OrthoDB" id="2440573at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="55" mass="6316" checksum="1115DFF44EBC033F" modified="2018-11-07" version="1" fragment="single">MEDFVEMNEKLIKLLNDDWSMFPHVRFSCAALLSGTVITNHNKATIVNCNEVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J492</accession>
    <name>A0A367J492_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002278">
        <property type="protein sequence ID" value="RCH84748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J492"/>
    <dbReference type="STRING" id="86630.A0A367J492"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="69" mass="7827" checksum="EC5E9A9F5B7549C0" modified="2018-11-07" version="1" fragment="single">SNEYVSGLELPDMTNGKTLELLREWDGDKNSMSRIKTIRVRKPLSEESKAVTPATKEKSDKVNDLMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J513</accession>
    <name>A0A367J513_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002195">
        <property type="protein sequence ID" value="RCH85054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J513"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="77" mass="8593" checksum="A223542BD69B3782" modified="2018-11-07" version="1" fragment="single">MPYLALLVDKLIELYNEITIAIDVYPKGNTLNTILIFEAYDIFVYREASGFLGHSCAFACSMCKAKINMADGCLNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5B3</accession>
    <name>A0A367J5B3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002177">
        <property type="protein sequence ID" value="RCH85128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5B3"/>
    <dbReference type="STRING" id="86630.A0A367J5B3"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="34055" checksum="7102270AE88A9CCA" modified="2018-11-07" version="1" fragment="single">GKRRSKKSVSQEEVSLSPSYEFLEEIRQRDPLNKACADCSAENPEWCSINLGVVICIECSGVHRSLGTHISKVRSLTLDLFSPQVSQLILLIGNQNANSIWEASKPENKPEWNTDKETRHQFIYAKYVQKRFMKPSEGAPSMQLLEALESKNVLKALEAIAHGADVNDPYPVDMLPNPVSLVPSSNVFLRLPVLDVQGNPYPDKVIDISIPSRSAPKTKKEYYVIRYPIHLALYHHDFTMAELLFQYGSDTHKLDEVTGCSLADLIGYGHHVLQDDIFEYLNNKNRSRGQALISKLNHIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5I9</accession>
    <name>A0A367J5I9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002167">
        <property type="protein sequence ID" value="RCH85166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5I9"/>
    <dbReference type="STRING" id="86630.A0A367J5I9"/>
    <dbReference type="OrthoDB" id="5597279at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="82" mass="9252" checksum="498364E084083C2D" modified="2018-11-07" version="1">MNNLRQKLSIQHGTLPKRLRYSFQLEPRHISTIKRYNSTMVKPLEGIRVLELGQLIAGPFCGSILGYYGAGKAECDQECGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6N9</accession>
    <name>A0A367J6N9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002059">
        <property type="protein sequence ID" value="RCH85593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6N9"/>
    <dbReference type="STRING" id="86630.A0A367J6N9"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="127" mass="13961" checksum="317E2C2D2B395D29" modified="2018-11-07" version="1">MMRFAKPFVRHASTASAASKPEKFLQTIVLSNGATYTVRTTSPTRSQIRLTKDTRNHPLWNPAMLKEGVTDESEQLTKFQQRFGDLDLSDISWIESDEVVSTTLKKAAASGGYNKKAAAAAAKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7Q3</accession>
    <name>A0A367J7Q3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_008908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002020">
        <property type="protein sequence ID" value="RCH85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7Q3"/>
    <dbReference type="OrthoDB" id="2338553at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41725" checksum="B8736C95232A1416" modified="2018-11-07" version="1">MSPCHSFHECPLRSYSLLIINKEKQTIVTGTDELFDILGYKEPHQLIGKSIHLLNPQKKKDHYVLHHTSSRHIPFEICIHHDPLTNAKDLDYWLIRPLDNRHSNTLGPVTILRLSPFGTIENAYPSVDFPQKHTELQHQPIMSFIHESDLITVCQRLSKTRYKSHHTLRIRWLNHHPRQSTHQTADAFQWVMLTVMNAPRRLSCSSLDDPQSRPICIVRVLYDSPEEAPPPVSINDCLRLACFEAIHLLTSQLSQGTLQLHNWIDSIHAALDQGKAYLLEFIAHLLSYALDFTNELGILYHPPIQECSTKEDDLDMEDMINKKKYKVYSNTTTPMIKVYDNNKQLWSIPLFRKNCYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7S5</accession>
    <name>A0A367J7S5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001969">
        <property type="protein sequence ID" value="RCH85978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7S5"/>
    <dbReference type="STRING" id="86630.A0A367J7S5"/>
    <dbReference type="OrthoDB" id="2250876at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="16110" checksum="2FB8833A8D5D6ED0" modified="2018-11-07" version="1">MFNALVTSSLRLDALFDPEIGPGTASFDLRDSPQAKNTAIFIKESAWKAAVEIAQNNNAASIIPYDLIYQLRQLRTRFHQQSTYFLCRASNETVDNLAARLYTIYTLAEWNNVNDNADYRTTSKLFRTIAINVICGNPRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J887</accession>
    <name>A0A367J887_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_008064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001928">
        <property type="protein sequence ID" value="RCH86153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J887"/>
    <dbReference type="STRING" id="86630.A0A367J887"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000079">
        <property type="entry name" value="Ubiquitin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="415"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00071717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="461" mass="51281" checksum="2DD0B48EFA6E6B10" modified="2018-11-07" version="1">MAPISINVRPSTGRTFKVQVDTEETTVLRLKDIIATSMGDVSSNDLKLVFSGRILKNEDKCSDYKIAEGNTVHVVRSGTNRAPAKPKTTASQEQEQQQSQQQPQQQQQQQQQPQQSTPTAPSLFNLPGLSGNMNPFGGDMGMPNMDPELIRQMMDSPFMQSLLDNPEFIRSMIMNNPQIKAIAEQNPEVGHLISDPSFLRQSIEMMRNPELMREMQRNNDRALSNIEAIPGGFNHLRRMYSTIQEPMESAMSPAGLRSSEEANERLARQLNVSSVPENSLNTQALPNPWAATSQQSPQQQPQQNNSSSTAQQQPFAQNPFASLFGAPMFPLGQQQQQQQQQQPSQSADNQPSSTMPFWADPNFMQAAMRLQQSLLAAQPRNNESTSQPNLFQQMMGIPFNNNIFGAQSQTQTPTEPPEVRFRDQLAQLEEMGFSEKTANVRALLATGGNVEAAIEYLLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8V3</accession>
    <name>A0A367J8V3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001877">
        <property type="protein sequence ID" value="RCH86394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8V3"/>
    <dbReference type="STRING" id="86630.A0A367J8V3"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="279" mass="31978" checksum="CB9D4B9B8C0090F0" modified="2018-11-07" version="1">MSDALLDDTNQFLVSHIKSTNDLEIAKLKSLLEAQKAEQKELDAKLNKIAHASKKALIDSEENLNTQQKALQQLLGNLEETKQHVEKYEADHSTPTTSQHELLIHLKQLEEKLKRVDNARNYIKTLLVACELSSQALDYVETDPGKAIKPYEQLVKFERYISNQPMANEQYSELCDYLKKRQTQLWEELNAVLIKSFKSALGALSWPTPIKPPYGPQIKEKLEKFESTFRHLIILQQSSAKGQQVSELSPVSIMLEDLSLRFKYHFETSKPTNRLDKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J945</accession>
    <name>A0A367J945_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001871">
        <property type="protein sequence ID" value="RCH86415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367J945"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="396"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="697"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="902"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1074"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH86415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1294" mass="147653" checksum="6D2F2D5115995621" modified="2018-11-07" version="1">MRSLELLGHKLFKVANQEIKGRSFIAIDPESNTVYTAHVDSNSHVIVSANNSVPGEPNTFVQIGSCPTQGIVNFTYVTDLQAACLSTYDGDIILFNKERFEKGEEAMEVVGSVDSGIHALCWSPDQDLVVLVTGEKNVLEMTQDFDTITEFQLHVEEQGEGVHHSVGWGKKETQFHGSAGKAAAQQKVDTSKFTISEDDDMKPRVAWRGDGSFFTISDVDPNKNARVIRVYNREGVLQNTSEPVDKLEQALDWRPSGNLIVSTQQLPHRHDVVFFERNGLRHGEFTLRETEQNKQRVLETLWNADSTILAIWIETKIAGKLQKTVQLWTTKNYHWYMKQHIVLSEGRDIVGFAWDVENAMVAHLFSSAGEYHRLNYTLEVFTSTSIDHLNSGYVAVIDGSNLLATPFVYQNVPPPMSSLTFTAKSDIQQVTFGYDDAGLKVAVVTNDSIQLVELPAKGLGDVTVLGEYDLPAITESNRSYGRNIIHQLRWINENQLVYCQYDNELETDMLCVMTLKTNEHDVPTVKAIPMTSQIGRIYFNATYKDLLIEDVEGSVYEVSELDQETPAVTKIHSFPDFCSWIASSRATFTNEQDKRVIIGLTDRSKLYVENNLVSSEATSLFVRGNWVVFSTTSNKARFLSFENVNIEDLKLHDSTADPYDETSRRLERGSKIVIATQQKPNLVLQMPRGNLETISPRAFVLAAIREDLKALDYRSAFIACRRNRIDLNILYDDNPERFMENIGTFVQQVADVDYLNLFLSNLRNEDTSVTMYRRGGKSAEDLTVAKGVENKVNTICEAIRNVLVQLGREHYIQSIISTYVRSSPPDIESALSLLSELRESDLSAAEEALKYTIFLCKAEHLYKVALGMYNFPLVLMVAQQAQMDPKEYLPFLQELKSLEKYYQRYRIDDHLKRYEKALRNLSQAGDEHFEELMNYMKKHDLYLIAIEEYANRPSQKIAILNVYGDHLSFKTNYEEAGIVYMMADNKTKAMESYRMAGCWREAFSIAKQLEYTNEEIHALAYDMIEYLKEKRRYQEAATVAKDYAMDIEEAVDCFLKGGFWKEAERVSYTFNRPDLIETHVKSGLVEGLTQTEEDIDEMLAQFHKQTTRLTELRTKKVEQKIENPMANDESLDNIDMFSDTTSMYSQFTRYTNASSRVSSVTSQGSGRSRKTSKLRRKEERKRARGKKGTVFEEEYLVGSLKKLYEKASNMQNDIGNLLRALVPFGYVDEARSIQEKFEKFLDELKGSMETIFVPLQLAVSLYASPEEYEEARKEPLKPVEKPVMAKVEWKLQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J973</accession>
    <name>A0A367J973_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PYK1_4</name>
        <name evidence="18" type="ORF">CU097_008915</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="PJQL01001858">
        <property type="protein sequence ID" value="RCH86477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J973"/>
    <dbReference type="STRING" id="86630.A0A367J973"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="27"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="387"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH86477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="528" mass="58176" checksum="1BE9D10F0CE518D7" modified="2018-11-07" version="1">MKLNNVTSSELEWISQMDVDVECSHTRKTSIIGTIGPKTNSVEMITQLRNAGLNVVRMNFSHGSYEYHQSVIDNTRKSFQLYPGRATAIALDTKGPEIRTGLMRDNIDIPIKAGHEFILSTDEQYKENCDDKVMYIDYKNLPQVIQVDKLVYVDDGILSLQVKEVLPDGVRVVALNNGTLSSRKGVNLPGTDVDLPALSEKDKADLRFGVQNKVDMIFASFIRRGQDIKDIRQVLGDEGKAIKIIAKIENHQGVANFDEILEQTDGVMIARGDMGIEIPLERVFIAQKMMIAKCNLAGKPVICATQMLESMTYNPRPTRAEVSDVANAVLDGADCVMLSGETAKGSYPIEAVQMMHQTCLLAESFICYPRLFNEIRSLTPLPTSTTETIACAAVNAAHEQGAKAIIVLTTSGKSAGLISKYRPSVPIIVVTRNPQTARQVHLHRGCFPFHYPKASSKEASALSASYSTDYLSPLNLAPWQDDVDARIKWGMEQAIKYGLVGHNESVVAIQGWRGGLGNTNTLRMLMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAN3</accession>
    <name>A0A367JAN3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001760">
        <property type="protein sequence ID" value="RCH86955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAN3"/>
    <dbReference type="OrthoDB" id="2117820at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="296" mass="34253" checksum="342BA6B41507B67F" modified="2018-11-07" version="1">MTLLTSAYKRAIRHTPGLFWRSISSSPKTIKDFPWLLSKDKPRITNYPYETTDPVMGMIPISLQRMATNWVATRILQLNTGMNYFPDQFLVGASLATRKALQLLSDQLQHPEESREEIEHIFGPALLHRYIESAPSDANISIQLPQIYDVNVDDIWVTMGNPAAYSDENDKYDIFRWATLQFGVNKGKNEEQESFQEYKQRIRESIIEGIQVSVDVVVDADIVYQATHKETDEILLHDEGRRDLRIRFATPYFQPASKMVRSRDSETGEPVISWSWRIVDIDQLIEKEAMDSHEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB55</accession>
    <name>A0A367JB55_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001731">
        <property type="protein sequence ID" value="RCH87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB55"/>
    <dbReference type="STRING" id="86630.A0A367JB55"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="504" mass="58149" checksum="E329B2CDFB5751AE" modified="2018-11-07" version="1">MRSIELLDSDDKDTYFTEEENEDKRVLSYDSGVNSSINDDDDDDKSTLEEMMDLLPPKRVPADRKKVQRIKRGLLKRIIIDIQAIISMTLSLPILIVLVLLAIYKTTKTHVLDVLYHKTERSQDILENALPDEDITQDETYYAEKWGYISEKHEVVTEDGYIIIIYRLYRKGCKPSGRKPVLIGHGLFQCSGAFVLNEEKSIAFTLADAGYDVWVGNNRAIAGYDHISLSYKDPEYWDWGLKELGIYDFKAMLDHVREYSGYSKVAYIGHSQGNAQAFIGLSLCPEIASKLSCFVALAPAIFSGSLVNTYPLRLLINLNDWLYSMLFGTAAFLPVMTVVQTIMHPRLFCFLAYCMFSYLFSWWDSHWVRRRKVKYFQFTPRPVSARLIADWIAGWGKTGKCLYVGEHKHDNTQMDKVPLIVFYGTADYLVDGEQFVRSFDDCEHRLTDTKEASSKNNTTMFPMLDLVHVERIDGYEHMDTIWGHNNHKTTYPILLKQLKQAKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBC6</accession>
    <name>A0A367JBC6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_008805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01001696">
        <property type="protein sequence ID" value="RCH87253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBC6"/>
    <dbReference type="STRING" id="86630.A0A367JBC6"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041429">
        <property type="entry name" value="ITPK1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17927">
        <property type="entry name" value="Ins134_P3_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol-tetrakisphosphate 1-kinase N-terminal" evidence="8">
        <location>
            <begin position="462"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="7">
        <location>
            <begin position="575"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH87253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="767" mass="87454" checksum="B1F4AD309BD91267" modified="2018-11-07" version="1">MSSNDWTPTSWKTKPIAQDVVYEDQERFNKVINKLNRLPPLVSATEIENLKSQLKEAALGNMFLLQGGDCAELFDYCSQDPIEAKLKVLLQMSLVLTWGARTPVVRIARMAGQYAKPRSKPMEMYEGKEIHSFRGDNVNGYDPQDRTPDPERLLGAYFHSTATLNYVRTLLDSGFADLHEPSKWNLSHVRSDSVRREYQNIVSQLTDSLDFMRTVGADNGGAPSALTSIDFFVSHESLLLEYETSLTRLMTSPTKEKKWYNAGAHFLWIGDRTRQPENAHVEYIRGIANPIGIKVGPSTVPEDLVRLLNTVNPDKEIGKVTLITRFGADNVEKHLPQHIEAVRQSGHIPVWVCDPMHGNTKTAASGKLKTRHFVDIIQELSQTFRVHKECGSKLNGVHFELTGDSVTECIGGSMDLTDEDLPGNYQTYCDPRLNYEQSLDVAFLIAKYYENERRAKDFPNLKKIERSGFIGLEDYAIKRNIRIIHIDLSIPIEDQGNLDLIVHKMTDVVAKVERGDQEAKRLYERFITYCQRHPYVRVIDSWSNIEKVLDRMVLYHHTELCALTNMIDGKPLFYVPKSVELSSIKDWKKNMGVRFPAMCKRRTACSSTEAHQMILIPSPEKMSQLEKYIENEPVMLQEFIQHDGVIVKVYVADGQITASTRPSFKNLDTTGDVVHFDSQTLPKSFETKIELSDDLDKIFLRTNPGDILVQKESLLDNDRLKQIADGLYRQLGLTFFGFDVLLQSKTNDYYVVDVNYFPSMCDRVCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBJ8</accession>
    <name>A0A367JBJ8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPS28A_1</name>
        <name evidence="4" type="ORF">CU097_003766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001683">
        <property type="protein sequence ID" value="RCH87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBJ8"/>
    <dbReference type="STRING" id="86630.A0A367JBJ8"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH87310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7494" checksum="AC0066A09BBF50F9" modified="2018-11-07" version="1" fragment="single">DSKTPVKLARVTKVLGRTGSRGGVTQVRVEFMDDTNRSIIRNVKGPVRENDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCD3</accession>
    <name>A0A367JCD3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001634">
        <property type="protein sequence ID" value="RCH87545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCD3"/>
    <dbReference type="STRING" id="86630.A0A367JCD3"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH87545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="236" mass="27865" checksum="3CD8ABCC06AC1C07" modified="2018-11-07" version="1" fragment="single">MNSIQSVYHSSFDHPSLANDEWINHYQQKELERLRQVQHQAALQQQRALMHQQMLYYHQQQQQQQQQQQQQPQPQQQPAYIHDYYYYPQQHYISSPPFGLEGSPNMAEKAQKRAEHNAIERQRREVLNTKFQQLALSLPNLQHDRRPSKGTIIERTLEYVKQTVQKEQEFKYQIDQLRKANRTLFLQMASLSDDDLEDDDEQISNTPEGDCDDTFSCKSSITSSPTLSDLPILMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCT1</accession>
    <name>A0A367JCT1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001598">
        <property type="protein sequence ID" value="RCH87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCT1"/>
    <dbReference type="STRING" id="86630.A0A367JCT1"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="131"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="307" mass="35488" checksum="D7BD11C310EA5991" modified="2018-11-07" version="1">MVHSSLLEAVQFCDKYPYVFEKTEKQPVAFKHDDALLGQILPNVISALTEYNNSVSPSPFKIEPDLVTFANWVDTFDKRTEVMKVLADTWRERKLFPVLEGWRNELYPIYGHHDLVFVMERAATPLFGVSTFGCHLNAYVTDNEGKIHMWVARRAKTKPTWPGMLDNCVAGGISYQYRIKDTIVKECDEEASIPAELASKARSTNVISYYTFTDGGLQPETEYIFDLELPQDFKPTPKDGEVDCFYLWPLEKVKESILNQEWKSNSALVAIDFMIRHSYITPDEEPDYIKISYHLHRKLEFPTPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDN9</accession>
    <name>A0A367JDN9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-protein Rab-11A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001531">
        <property type="protein sequence ID" value="RCH88092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDN9"/>
    <dbReference type="STRING" id="86630.A0A367JDN9"/>
    <dbReference type="OrthoDB" id="2225549at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24421" checksum="AB806D8824CBBA51" modified="2018-11-07" version="1">MTEESSYDYLFKIVVIGDSGVGKTNLLSRFIHNTFDFASKSTIGLDLSMKNIIIKDKRVRVQIWDTAGQERYRSITKRYYRGAVGALLVYDITKRESFMNIPRWLNEIKSNEAHPESILMLVGNKSDLEKDRQVTLEEALEYAKVNDLVFMETSALESINVENAFDSLIHTIFDKLSSKLTTMDDKKTKFLRGQTVQLNNTIHHSKHNNSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDZ7</accession>
    <name>A0A367JDZ7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001517">
        <property type="protein sequence ID" value="RCH88173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDZ7"/>
    <dbReference type="STRING" id="86630.A0A367JDZ7"/>
    <dbReference type="OrthoDB" id="2288643at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="200"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="402" mass="45110" checksum="F84F5959A691F92E" modified="2018-11-07" version="1">MTKPSTFAASFISQHQANTTMTSTTVPATNPVSLDSIMSADDILSESAPFEATSLSNVLAVGSVPIAMILTDLCYKLRALILQLFALIASLTHRLHTVTISSDLEQTLTKELQAHKEHLQMFKNTIDVFSAYDVTATTTIMHTALSHPCVVPDNLPMMQWRGSVFDRRSPVASDIRARLKRFEDALSSHGLDYDSNWRRLIPVYLSCEQRPWLDAYWETKPNSTWKFFKYAFVTRFGMSPPVEISNSCDELLTITMGPNESVEQYVYRFKVLRYLSGVKEPIALFVCFMAGLSADLHERFAKKINNKASSSSCSVKKRRSIPCVARSRSQPYKKSSNNRYCSFHKNHSHSSAQCRTLKKSKIAGDKLPSPSSGMTRSSWDPSDTGALYSRYVNNTRAAKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE44</accession>
    <name>A0A367JE44_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001510">
        <property type="protein sequence ID" value="RCH88208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE44"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="131" mass="15155" checksum="411390A30613456A" modified="2018-11-07" version="1" fragment="single">IRKVAEPYHLHCKQKAHKRRAIHMQYSESITQTVLQYVGNYTDEDNETVYYKSRLHSDPSEKKLDQMMDRLVTEKEYNFNSPRHSSDTCSISSTNTSYCSTPGNSTSGGQMNPVLKSNHHDSILDIRQCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEF7</accession>
    <name>A0A367JEF7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_003045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01001499">
        <property type="protein sequence ID" value="RCH88265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEF7"/>
    <dbReference type="STRING" id="86630.A0A367JEF7"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="150"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH88265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="445" mass="51458" checksum="6289F51FB0DF1B75" modified="2018-11-07" version="1">MATVIPPVKLVYYTSCSSLQLKRPFDKDTDKDIGRDCPIPDGYVFNLTGQTTWCTLTSSTDHWQKASGLIFHAADIHYDAFPPRIDNQPRILETLESPITAPFRTNPEQMKNYDYLATYNFKSTFFFTYFSPSIMDVVNRPLPHDFMETKTKKAPILWIARNCRATSGREYYISELMKHIQVDSYGECLNNQEFPEDKSREELMAEYKFYLAIENANCEDYVTEKLYDTFMMSAVPIVDGPSSYEGYLPTNRSVIYMDAYPDPKDLADYINYLDKNDTAYLEYLSFRRDALKIAANDRLEPAFISNWSDTIAHKKRSDYCSICRGVLPWWKNRHTAGSDVYKDESERFLVDDSCQPGGKWNYISLGRPYKPHWKPRPLDEFTRPRAMLDEPAQDDEKMIELIGNDTHAMAITANIVFICILLSFIIVLSRVSRTTNKQSSTSVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEP6</accession>
    <name>A0A367JEP6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001512">
        <property type="protein sequence ID" value="RCH88201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEP6"/>
    <dbReference type="STRING" id="86630.A0A367JEP6"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000008">
        <property type="entry name" value="GAF domain-containing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="180" mass="19882" checksum="A5D9EC274ED6E24E" modified="2018-11-07" version="1">MKEIPAITDQSASKKDFYEILLAQVESICEGQTFWVTNLSNVSSIIYHGLMSLSHFQNKPINWCGFYLTDPKNDQQLILGPFQGKVACTLIPFGKGVCGTAAKTRETQVVKDVHQFAGHIACDSASNSEIVVPLVKDNRVLGVLDIDCEKTEGFDEEDRKGLEVIVEAIIKSCEWPETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF91</accession>
    <name>A0A367JF91_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001442">
        <property type="protein sequence ID" value="RCH88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF91"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8615" checksum="1CE50E6D82E75A2D" modified="2018-11-07" version="1" fragment="single">MSSQEVDDEKEILLKHLETLSWEEMSKRIADSRHEVSHLLGVSIDNINNNEPEDSSILFNRAVHSGNILKLKEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JF99</accession>
    <name>A0A367JF99_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA ATPase midasin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MDN1_2</name>
        <name evidence="4" type="ORF">CU097_009830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001440">
        <property type="protein sequence ID" value="RCH88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JF99"/>
    <dbReference type="STRING" id="86630.A0A367JF99"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="337"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="681"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113902" checksum="35A98647C27E8DF6" modified="2018-11-07" version="1" fragment="single">MVEATEDNIFDPLSFDFLAAVQQLSAYVIEQEESALDAIIDHEVLKNPNSISRSDLLDLVSRAMINPSWTLTVVRLFRPIVIDLIGRWTMPGFTTLIETALSKTHTTVHTTELIAKAFSVILPIAPQVKNLAVLYFTHSTSLFERLDHYSNVDSMDISTSSSSIDNLHDLLLTTYRLLSFSAVTFSPIWNWGPVVQLLKYPDTCVRYITTLCLCKVYNLSDSQQNSLLSSIVGKPLDESDEPIYITIEGSRVDIRFLDLWEQQRLADNQIAYLANNFDVQQRQLEDSDLCPSTCNLCGVLLTKRVEKESDRSSYNPELVLTKTTSKNLHAISLALSIGAPTLLEGVTGAGKTCLVEELAWRTGRGAELVKIHLGDQTDPKVLLGTYVSTSTPGSFRWQAGVLTTAVLEGRWVLIEDIDLAPAEVLSVLLPLLETGHLFIPSRGEKIKAKEGFQMFGTRSFLPSRSGKGVTSRGASMMTGANLWTRVHVEPLSHEELEQVIRQKFAHINDFASHAMNLFQTVVDLYEDTSLSLSSSSMGRFLSTRDLMKWCHRVDLLLGEKLNDSSEVGMDLTLRQDLFNEANDCFCGMIPDYNIWMTVLQTIGKPLQISQELVRNYVDQYKPVLDVNDTHVRIGRVNLSSIAASGKQKKKAGLIKREKQRPFATTGHALRLMEKIAVSIHLNEPVLLVGETGTGKTTVVQHLADMIHQNLIVVNLSQQSDSSDLLGGFKPVDGKVLAIPLNDEFERLFEKTFSVKKNIKFLDMVRKMFIHQKWTNFVALLKQAIKMSQQKFEAEQNVENKKTSSPQLRNAWKTFAKHVEEFEVQQVQSQNKFVFSFMEGSLVKAVRQGDWILLDEINLATTETLECLSGLLQDVNGSLLLTEKGDVEPIKRHPNFRLFACMNPATDVGKRDLPPGLRNRFTEFYVHPPDNRYDDLLQIVKQYLYGIAAGDERCYEDVADFYTSAKKLANEHKLVDGANQRPHFSMRTLARALTYVVQISPTYGLRRSLYEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFF2</accession>
    <name>A0A367JFF2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DAL2_5</name>
        <name evidence="3" type="ORF">CU097_011736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001429">
        <property type="protein sequence ID" value="RCH88654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFF2"/>
    <dbReference type="STRING" id="86630.A0A367JFF2"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="14505" checksum="CF88A6A0369E4098" modified="2018-11-07" version="1">MGDGWETKRSRTPGHTDHVTVKLGAKGHLLKAVIDTSHYRGNYPNKVILKAIHSDEFVPSQPDSEWVTLIEPTSVGPHGLFYFDLPQTDKVFTHAKIIIVPDGGIKRLRLYGVREGGKVPPTPIDIGDAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG39</accession>
    <name>A0A367JG39_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase I subunit rpa49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPA49_1</name>
        <name evidence="7" type="ORF">CU097_006873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001394">
        <property type="protein sequence ID" value="RCH88845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG39"/>
    <dbReference type="STRING" id="86630.A0A367JG39"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH88845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="410" mass="45707" checksum="760E0FA8799FE5F2" modified="2018-11-07" version="1">MGKRKHSDEQSSRHVKIVVAEKQTDVEPPYLVAFPGTKPPSDLIYTPHRHEQEDKKAEQRVISGETEKVIYTGSNFGRDAIDTHCKYLVGVFSKKENTLSITNAPIMRMNRTVKALQSESSVQGSTARGMAARAALGLAFGTVKAKKQLNSDERNLVTGEQLADEMDNLHSEIGKSTANIPKKDELKKSMETALPVPKHNIEAESPEEAYDLSSIVTDEELNSINPKELLKETSLEGVKSHLAYRDSKFINDRLMAIIAASGKKDRKRVRTLMYINILMAYYVRVRASDLKDRRKVETALKNPSSIILDGLAERYTESNTRTPVMADKLLLYMFTLILSVSGYSVVIDQLGKDLLLKPIKITSLFKTLGCKIDKASTEECRELGTKSAKKAQLIVPLKFPEVRTGGGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG67</accession>
    <name>A0A367JG67_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001384">
        <property type="protein sequence ID" value="RCH88907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG67"/>
    <dbReference type="STRING" id="86630.A0A367JG67"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="201"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="53631" checksum="150AF363A385B6F4" modified="2018-11-07" version="1">MQRLLPKAALRRSICFSCYYRQTNKLNNKRAFHSSRPTHVPLVPFPAFLLGAFKTGKLVSVISLSSKTSLTLLPHTFRRGKGSKLQLVAKILAGIPLFGVGLLFAVGLDQAPNTSRLRLIYLSEEEEEDIVKDEINTLLDAQRGLVAPRDSEAVIWLQTIVDNLAAVAVDDIRDPVRQYSIQKKETVNDSDSTEVLVVPSNDIETIVSSTADEIRANIPKRNFEVDFICDSTTVNAMCVGSHIVVYDLLTQYMEYDSSKMAVILSHEIAHSIQRHFVEQHGFAALMFMLGDITRGVFWMVTESLGPYVNQKINDYISMFITLETQTTYNRRLEKEADLVGLMILAKAGYDPRVAIEVWERMAELENYIDDKAEQVVAGSQNKAIDTVEELQQVNIVEFFSTLISNWFGSSHPPSEERIEYMKEHLDEAIKVYEQSIQLNGYPKEYIFQMDDVGNNNSLFTNVKNWLSSIIITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG89</accession>
    <name>A0A367JG89_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001367">
        <property type="protein sequence ID" value="RCH88992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG89"/>
    <dbReference type="STRING" id="86630.A0A367JG89"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33107" checksum="08B86121D1E6679F" modified="2018-11-07" version="1">MATCCARLSKVYMIITNTLFACLGLAFIAFGLIGFKSGFYGSSLFPADIFRWLAILGAIICVAAIFGAIGAFIKKSFIIYIYMIIIIAALVLQVIIGIKLYQAAANAPAYMSKLWTSSSMSQRASLENEFHCCGYQTSIDNYAPTDQCQPTKSAMTPLPICADLLIGYAKTTFNKAYLVVFAALALEILAMSNAITLICTSFGADEESERRKRRKSGIRLDDMSVETPTTLVGSAYTITDEQKKYYAGSPGAGSYNAYSADTMHSPARSNGYDAYGHQDANAYHAEHYGYPQYNSQSRGNAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHL2</accession>
    <name>A0A367JHL2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_008880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001290">
        <property type="protein sequence ID" value="RCH89423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHL2"/>
    <dbReference type="STRING" id="86630.A0A367JHL2"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH89423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="15759" checksum="F07F2B6DA63ADD72" modified="2018-11-07" version="1">MSDHEEVIDSQEVEVAVETTSGQMSVEDALQEVLRRALVHDGLARGLKEAVKALDRRQAHLAVLVESCTESEYIKLVEALCAEHNINLIKVADAKKLGEWAGLCKIDREGNARKVVGCSCVAVTDFGEESEAMNVLLDYFKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHQ0</accession>
    <name>A0A367JHQ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001281">
        <property type="protein sequence ID" value="RCH89478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHQ0"/>
    <dbReference type="STRING" id="86630.A0A367JHQ0"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40953" checksum="17287BE6232A0D1B" modified="2018-11-07" version="1">MTSLVTSILNNKMTNILGSNKQKSKTNTNHSSRLAMYANNNSNSLYRQPQMSYSAEYIPAPPPYDSPIPTPSTSWTSEMSAFAEKIKEDVTNTFKSSKHTAADRHSISQGMKLISIAADEYDQGNESIALDIYLTGVDKLIMALPNKSDTNTKRILHEKLTSVEERVGIIQLPRKKNQENSDNSSNSENDDNGQGSMLLSRIVSTLSSVSSRAYAAAVNSNSVPDNSSSDTTTTTTATGTTCNSATRTTFTSNTTNTTQPLDDPIIRFKKFGQYLTEWTVTLAVLIKQSPIPDIFTFLFGYMIQLCLWIDKQYCITEKAQDLGIQCLKIGLEADQHYRLHEFITEGIYMFITAGLKAIIAFKETSNYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHU9</accession>
    <name>A0A367JHU9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LMBR1 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LMBRD2_2</name>
        <name evidence="8" type="ORF">CU097_008625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001273">
        <property type="protein sequence ID" value="RCH89528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHU9"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="674"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH89528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="780" mass="90084" checksum="7B808060CD551A5B" modified="2018-11-07" version="1">MQQLMAETSSWLPLVIVTILLFITVIVNLFRYGNIKTQPWFVSLTCIVGWFFPFWIIILLPLDLASTIHDKLDGRLPFAYVSRSFLFVAWRVIYWTSFCLTWFMIPMMQAYMNTGDFTISRRLRSALHINLRFYSIYVVVGFFGLVYLIFGNGYTTRDKIQSYVMAAANSWGLFLVIIFMGYGLVSVPRHFWHHGDFMRHLLQHYANAAKLKEEYMDSELELNEVAKIMNAISKRTHREIPRIRECIHIMIGRFPFVTQECYSGISTSGRIPSQLTEDYLVKLSRRMILAIRMRNRKKALWNNLLEEAFYLQDIIKNKDTSERRFTSTLRVKKDDTKWNIFQSAVEWWWAIRIAPLLYRILAILFSVISVFIIWSELTFNVKSPTLSIVSWALKACGTNYAAVEFMAFLTITYMFVCVYSSLFKIRFFNLYLLIPNHHTDENSLLWFTGYMCKMMAPLCYNFINLAGDAPFKEAPASDSVFSTFMGKADLFEFLGAFVDWFPVVILIPSLLLFFNLQDRFLSVFGIKNVYKSNDEDVGANESGRLLDADYEEGKYLVLEERTAREKEINPELRVSSRRRPQSPPHIQAFAAKYSRLGQAESSRDERNRKINELLEGRLTAKRYRDNSAASSTLSLPSESAYSDTVKLKTKSFGDTMKQKIDDIYNAFKSNTDLPSQNQSSSAAFAQSPPMSPRSSSSSNNNSRGRVFGRRSTESNNRGTGYNNEYHSTPSEVNSEHFSHNPSALGIHQARNHSSSPFIRHDDPYTNDANEPRPNNMFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHV5</accession>
    <name>A0A367JHV5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001274">
        <property type="protein sequence ID" value="RCH89520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHV5"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="211" mass="25016" checksum="7E969EC844D9E79B" modified="2018-11-07" version="1">MAYNIGTIQRQLSSLIEDFKHTRNTWDEINSHAFPTANKLSNSIIQSRYTDESEYWHPLLTLEFQNIIQQYEYKMQTIIKKQHDQLVDLVQKMEKQHSKMQSQFKDLCSICLQVKKVHGDEFLKTKSIYKTCPLDTYRKRMKELVEMYSKELETKKRLVSDQGFASIQSKDEAMVLLSIWINQPSIVMSIIEEWDDLCTVEMDTGNRAKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKB8</accession>
    <name>A0A367JKB8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1764 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001170">
        <property type="protein sequence ID" value="RCH90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKB8"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18860" checksum="CD23B5F31856680E" modified="2018-11-07" version="1">MAKNTKKGKNETKESTKPEKKNKVLDTSEIDDIFNTKKITSTSSSTSTEQATKKRKADSDTLSKPKKKAKETEIEEEEQDSKKVEEVVFAELAAVKSEKKTQKKPVVPPSDDDFGDSRGLKKPTRTTEEGYPLYDIKDLNIGLGKDTPECPFDCQCCKYIILYYNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLR0</accession>
    <name>A0A367JLR0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001064">
        <property type="protein sequence ID" value="RCH90809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLR0"/>
    <dbReference type="STRING" id="86630.A0A367JLR0"/>
    <dbReference type="OrthoDB" id="10534471at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794896" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12040" checksum="53CFBA81AED9FA5D" modified="2018-11-07" version="1">MRSTLISLALVATLALVSALPSNLNVDIVKRDTTLAKKSTAGAIYRRALNREASRVVRRDENEDENEEEEDDKGDDGEEESSSHDRRDFLGLDDILDLDELLEGISDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM58</accession>
    <name>A0A367JM58_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TYW1</name>
        <name evidence="20" type="ORF">CU097_000940</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001042">
        <property type="protein sequence ID" value="RCH90949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM58"/>
    <dbReference type="STRING" id="86630.A0A367JM58"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="68"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="354"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH90949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="686" mass="77939" checksum="CC6E04E0F8CA5A39" modified="2018-11-07" version="1">MSNFFNSLIYNFSNILSIGPEPPREGEEQCGTGCCKEQQSNNEGCCQGSGNSNGCCKDNNQILEIESVKILYSSLTGTAKTFANEVEEKLKSTKFVKIQKLETMDITDYDNDNLLNETSVCIFILATYNVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAANIDKWLGRLGATRIYPLGECDKNADQKAQFDVWSNGFISELQDKHTLEFAPTNIAYQSDDDDEEAEEAEATGLEDEMVDLEDMGKMATKIKAAKAKRAEEEEDFEDSKAKAKRAIGEDAKKQEKPQAREMVSPMILKNLTKQGYKVVGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIKQLKGVPGVKAERFQEAFTIRHCALSLVGEPIFYPHINDFVNMLHERNISSFLVTNAQFPDKIAEMVPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKGHNTEEIDGYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCRKLVSKLDGEYEISAEHAHSCSLLIAHKSFKVNGEWYTHIDYPKFFELVKSGKPFTSLDYMAKTPEWAVFGHEAAGFDPDETRFYRKNRKNVEPPVIKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JML2</accession>
    <name>A0A367JML2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001010">
        <property type="protein sequence ID" value="RCH91167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JML2"/>
    <dbReference type="STRING" id="86630.A0A367JML2"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH91167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7766" checksum="F5E7743BB1C15363" modified="2018-11-07" version="1">MGGYYTIAGKQVPNHKIAMAFIGSYAAIGSYYIMKPKAPQPATPPIQASSADEEAFIREFLQKAEAEEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPJ7</accession>
    <name>A0A367JPJ7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000906">
        <property type="protein sequence ID" value="RCH91890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPJ7"/>
    <dbReference type="STRING" id="86630.A0A367JPJ7"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23722" checksum="C6B35599425EC200" modified="2018-11-07" version="1" fragment="single">MTNILGSNKQKSKTNTNHSSRLAMYANNNSNSLYRQPQMSYSAEYIPAPPPYDSPIPTPSTSWTSEMSAFAEKIKEDVTNTFKSSKHTAVDRHSISQGMKLISIAADEYDQGNESIALDIYLTGVDKLIMALPNKSDTNTKRILHEKLTSVEERVGILQLPRKKNQENNDNSSNSENDDNGQGNMLLSRIVSTLSSVSSKAYAAAINSNSVPDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPK9</accession>
    <name>A0A367JPK9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000907">
        <property type="protein sequence ID" value="RCH91884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPK9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8210" checksum="522F10148B06E124" modified="2018-11-07" version="1">MYLKAPMAAKKLLQRAYFVSNLFPERNVPAVRVGVDLVEIDNDAYDICRGNVSSKIMSAAADNTKTQFSLDGTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ13</accession>
    <name>A0A367JQ13_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DDB1A_2</name>
        <name evidence="8" type="ORF">CU097_012312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000891">
        <property type="protein sequence ID" value="RCH91996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ13"/>
    <dbReference type="STRING" id="86630.A0A367JQ13"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="6">
        <location>
            <begin position="4"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="359"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="5">
        <location>
            <begin position="716"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="784" mass="88168" checksum="C4115DCB34D35093" modified="2018-11-07" version="1" fragment="single">MLDGIKSFMEFNIYGTIRNMQVIQLSVNYNTLNNVDIHQCYTILTYSSKTQSIVTEFSGMLDITSARETDQPIVVTVDTSSETLFVSAFTGYLIAIPYGKPDSSIKMTTKNRDSKALRFMPVPIRTNEFDFLSVAALQQASYASVLVGELEDLKTIKTFKYCEGPKELVEKKNMAMKVEATTHTLVTVPAPLGGMLAIGEYVITYYDPFSNTVRELSIEPVLVTAWEYLSDGSNRFLLGDSEGYLYMFILETGHNKVVNLSSTLIGQVVRPNCIIDLGNYMFYIGSTHGDSCLIQLVNAATPSKYSIRVLANYSCLGPIVDFCLFDYNEQGKQTMACCSGVDNDASIRIVENGIGFIKQAVLDFPLVYNMWPLKLEEQSDSLLITTALETILLKPLRDADNQFMEYASYSGLCTNETTLASGLWNDHIVQITPSSARLMTKDEHGTLLAEWKPPRNKRISMAKLKESYCLVCDEDDTIVYLEIILNTFIERSTTQVRNTSCMSISTCKENGTDNNYVVIGTFGSGSNIRLLQLPELQMIYEHVNAPITASPKDVLIVFMEGLLYLMVMLGDGQILSYCIKHLGSEHIMLYDERQMMVSTYCTGMYPYQYQGEQRIFVAGQKPSVISSFNQTLFVYSVNLTNIYTLTAYNDILALMTDHQLLFGKTDVVSKLQHTKYDIPGEMPLRVEYLSRTKALAVGSSTYVRDTNKNVMERTGKVRILDAQTFQVLDTYELGNNEIVESMCVARFKEYPDKEYLFIGTLIENQLDPNNNSGRILAFTIDGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQB5</accession>
    <name>A0A367JQB5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_011029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000877">
        <property type="protein sequence ID" value="RCH92096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQB5"/>
    <dbReference type="STRING" id="86630.A0A367JQB5"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016967468" evidence="9">
        <location>
            <begin position="22"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="182"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH92096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="555" mass="63102" checksum="B99E66FBB6D5040D" modified="2018-11-07" version="1">MTRKLSFILLCLACLFSLATAVEVYVTSDEYSPTSCSGVWSKESIPGGTQPYIKVSIGPKSQGTVSLLVYEWKDFDKLGAYDDEVGETAYVCNRQAVSRKLCKSSQLGQFIMSIPSDQKNTTSIYTETLELKGNQTEAALYKVDKTGYYCVALAAVNQTNSFVEAWVEWRFPYGELPATDYPKLLLYGVFAFVYLAVGIFWFVQSFRYWRDILPVQHFLSAAIFYLVVEMAFNFGYWEAYNQTGKASYGLLALVALLNAGRTSMSFFMLLIVCMGYSVVKPSLGSTMRYCIILACTHFACGVVYTLGTMLLSPETAGYLILLVIFPLSITMTIFYVWTLNSITGTIRDLEIRKQHVKVLMYKRLYRLLVFSVFAVVVIFILNMFAYSTNVDFEWAAKSWKYRWFMLDGLLNILYFVVFFVIVVLWRPTSNNARYGLMQISQDEEEALDLEERLRRAEEEGYGNSTGHARGERHMVDESAVFELGEELTDEEEDNHPIHKVELSDINKNNRYNNNRGGKGADQSALLHVDQDDDDDDDHLDDSEHARLTGNARKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQK8</accession>
    <name>A0A367JQK8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000859">
        <property type="protein sequence ID" value="RCH92227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQK8"/>
    <dbReference type="STRING" id="86630.A0A367JQK8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44208" checksum="51CAA3EE3770F48E" modified="2018-11-07" version="1">MSQRCGLLTLPVEVQTSIFIYAQNPALVLTCRHFWQMGQSCLLRAKYLVFRYGREAALSERSMKRRIVCLPVIEHLIKHLHCDTTADEFWLYRHACETQEVDICRWIIAAVVAGNLANTSTLLSMAAACGAVDVVDILVDEFHVDLGQPYAHGSALRMATVYNHLDLVKHFDQKYKLDLHFDDELLLRCASYTGFPELVNYLLERGADVHANTDASLASAVHEGHASVAESLLKAGASATIHDNFCARYAAIRLQDISILRNLIVLGGVDPRFDHDWLLIEACKRGYIQIVRFLLKEILSDDIDNIINMREGILLKKAIIYEQEAVVHLLLDMGANVNSGGCAAGIYRLLNAQDRSMTAKNIIKYIVQNGFDIDQQTQVMQRAIRELLESKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQM0</accession>
    <name>A0A367JQM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BOS1</name>
        <name evidence="15" type="ORF">CU097_010797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000869">
        <property type="protein sequence ID" value="RCH92159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQM0"/>
    <dbReference type="STRING" id="86630.A0A367JQM0"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH92159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="216" mass="25301" checksum="2400C8A8BD7FAA8E" modified="2018-11-07" version="1">MNSLYNHALKQTHALQRDLEKFKSGDDTSIGLQGQISASFNTLQRSIDDYENLAKREMVPLKKETALTRVSKFRQDLQEMRTQFEFTKKQQENLKNEQNRDSLLRRPNRGSSNAPEHPYQPLSRDEFALREQAFVNNTDSQLDDFIEQAQNLLENLTDQHNILKKTQKKVLDVANYLGLSQNVIRYIERRSAQDKWIFYGGMILTVLIIWAIIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRB1</accession>
    <name>A0A367JRB1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000821">
        <property type="protein sequence ID" value="RCH92490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRB1"/>
    <dbReference type="STRING" id="86630.A0A367JRB1"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="305" mass="34280" checksum="0624E605DCCDADFE" modified="2018-11-07" version="1" fragment="single">MLRSILHKSQPFVAYRFYSTSRSAKQITSSQLTEWMNQKKLYSDMIIVDVRERSEIEEKGKIKGALNIPFSLSAELFKGALGEFNKEMPIIFHCRGGRRSDEAALMAEKLGYKDCYSLVGGIEAWQGPVQAFMNNHSPWVHTILEKETETAQYIVTDFATKEAYIIDPVLDYDPFASKVHTATADNLLRFIEGYELNVTKIIETHVHADHLSSAFYLKQKLPSKPEVCIGANVTKVQKAFGERYNLGLDELSPTGEQFDVLTSDGMQWTLGKDIHCSVISTPGHTPACMSYRLGDAAFVGDTLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JSS4</accession>
    <name>A0A367JSS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000751">
        <property type="protein sequence ID" value="RCH93022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JSS4"/>
    <dbReference type="STRING" id="86630.A0A367JSS4"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15607" checksum="DA3A47868E3EF58B" modified="2018-11-07" version="1">MDNNDTKNLKPDEYTKGLNREHVIRLTEESCKHFVEYTKAELKVTVEDCKLLENMNHITKEKYSQMNQMSQRIMGEISKLQNTYDQFDQFITQVDDIHQQSIKMENTIKALDEYSKHLENKLLANFSVNTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV72</accession>
    <name>A0A367JV72_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_001101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000653">
        <property type="protein sequence ID" value="RCH93807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV72"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="179" mass="20168" checksum="68F205C9796B8460" modified="2018-11-07" version="1" fragment="single">IFFNVIIDTSRSVAVLCALTGALMSATAYVTVRKIGQETHVLVHIVYFGFVASMISLLVYFVRLQQFVIPDYHQFNNALWMLGAIGPIAFLGQFLLSQGLKMAPTGLASVIQASDVVLAFIFGIALFKEYPGFSTILGSMIVVLMTTWVNVNRWRIYMTKNAAIRRRRSKDRLQQQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVA6</accession>
    <name>A0A367JVA6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_013869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000650">
        <property type="protein sequence ID" value="RCH93838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVA6"/>
    <dbReference type="STRING" id="86630.A0A367JVA6"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="261" mass="30652" checksum="048B2ED60A5718F0" modified="2018-11-07" version="1">MRLYAIPIVKDRWAYYCHSTIPVQSRLVKAVNWSSKKWEQLGKADPQTWKRKLYDRGSHVMNQLDYQEWFLKSVPAKNEIPEPIKSVAIHYPRMLEEKMLHHDLEKLLKERVPYHKKYMYYSAYWVPLSCTFVIVPLIPNIPLAYNLFRLYSHYKAYKGADHLNDLMNNGLVIYEQDKQLDAILDNKRFVTAADIKFPEQAKDEFKAKKPNLKLLEQDLEGVLSEADIKLIGEALDMPGIELELNRARTQILKGIALDKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWD0</accession>
    <name>A0A367JWD0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="15">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CU097_003878</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="15"/>
    <dbReference type="EMBL" id="PJQL01000602">
        <property type="protein sequence ID" value="RCH94217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWD0"/>
    <dbReference type="STRING" id="86630.A0A367JWD0"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000004">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCH94217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="146" mass="15761" checksum="570E85E281B796FE" modified="2018-11-07" version="1">MGALIVPSEYGYVLGVAAFSALHLMFLGAKVGKARRAAKVPYPYAYAEKSEAEKDPLKNIFNCAQRAHQNTLEVFPVYSTLLLIGGLKYPEISAAAGLVHCLGRQVYASGYSTGNPDKRTRGAFGYLGLITLLGTSSLTIYHLLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWD1</accession>
    <name>A0A367JWD1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000600">
        <property type="protein sequence ID" value="RCH94240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWD1"/>
    <dbReference type="STRING" id="86630.A0A367JWD1"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="15352" checksum="C85AD5AF71081152" modified="2018-11-07" version="1">MLDERQVRLYKTEMCRNWQEIGSCRYGHKCRFAHGEQERRHVQRSPKYKTQICKTFHLTGTCLYGVRCVFIHDEHQDSTNRLNALATPFVFHNEKMNMPSDFMWFTPLPFDRRYSFSSSSSSSSSAVTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX03</accession>
    <name>A0A367JX03_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF431-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000578">
        <property type="protein sequence ID" value="RCH94437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX03"/>
    <dbReference type="STRING" id="86630.A0A367JX03"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24757" checksum="5DA5EC41B15E350F" modified="2018-11-07" version="1">MSNKRSYIIEHMEDAMHEWCALEYKHMLQNIGPDHLYFTSLTDKCLNEGMPEELRSAQCYQLDVLNLPGVKKEEICLLDPGAKSELKPEDGEKFKYFLFGGILGDHPPRDRTGELRKLGFEGRRLGPLQMTTDTAVNVTKMIVEDKVPFEEIPFIDYPEIRFSRTESVTMPFRYIAELKTITTKEGEEKTIKKPLMPPGMMELLKKDNEMSLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXE3</accession>
    <name>A0A367JXE3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000589">
        <property type="protein sequence ID" value="RCH94331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXE3"/>
    <dbReference type="OrthoDB" id="2210039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="12926" checksum="A1BED8D2BEFB39FB" modified="2018-11-07" version="1">MAKDNNKKTTKSHLNNLQNDYEFKVYNKNVYDFDTFDYGPCTTVVMSRHQGFQWNDELFVNEYQRSAGYECHKSDSLEQRERRISQQYSVNQDVIDINLTEADRDVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXJ0</accession>
    <name>A0A367JXJ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PAN6_2</name>
        <name evidence="12" type="ORF">CU097_002498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000553">
        <property type="protein sequence ID" value="RCH94653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXJ0"/>
    <dbReference type="STRING" id="86630.A0A367JXJ0"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH94653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="35745" checksum="7BC8C343AE3DB43D" modified="2018-11-07" version="1">MNAIRVPSGIRVFNKIADFRQWRRSLLLEEKTLGYVPTMGALHQGHLALVTDAKRHCDHVALTIFVNPAQFAPTEDLATYPRTLQSDLDKLAGLGEGMASAVLVPQVDEMYPTGIELDVTKQKGTFVEVLGLSKQLEGVTRPHFFRGVATVVSKFLNIVQPDHVFFGQKDIQQCFVIRNMIRDLHFPTKMHICPTVRDEGGLALSSRNAYLTPKQKEYALTLYKSLKHMESMYQSGVLDAPTILQQGIQIIQDASDQVKREGHDWDMKLDYVSINSAKDLSEVSGEINRQDGCVISMAVFVGKTRLIDNICLDVELDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXK9</accession>
    <name>A0A367JXK9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_014155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000558">
        <property type="protein sequence ID" value="RCH94619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXK9"/>
    <dbReference type="STRING" id="86630.A0A367JXK9"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH94619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="32648" checksum="5DBDED01EABD09FF" modified="2018-11-07" version="1" fragment="single">INAILVFAPQIFKAAGLSGKGVALMANALSGSINLLATIPAMIFIDKWGRRPTMIIGAIVCCICMGIMAILAGRHGYGHDAITTESDTVDSMSMIDQKNPLVLLFDTNAPTIGFLVVMYVYVAAYSCTWGTLGWVYPAELYSQGVRAKALGISTAFNWITTYAVLQLTPIMLRNIEWRTYVLFCVMCLIIAIIVHLYFPETSVCGKSLEEVDLIFSCRFNYYDVNVHHPQTAAEALAQMEKVQQRDKNLYRFPFTPERSFSTNSQHKRSTLLPQYHQPSYVVKFPQDAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYQ3</accession>
    <name>A0A367JYQ3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CAT2_3</name>
        <name evidence="21" type="ORF">CU097_009060</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01000505">
        <property type="protein sequence ID" value="RCH95063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYQ3"/>
    <dbReference type="STRING" id="86630.A0A367JYQ3"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="27"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH95063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="613" mass="69691" checksum="679871A7432C7B39" modified="2018-11-07" version="1">MPHTPKTPVDPNAPGPMLRFQSNLPKLPVPDLNETLPKYLKSIRPLLSDEEYKRSEQAVKEFLAPGSIGHELQKRLVARANDPSIVNWMEDWWLDQAYMGYRDPVVVYVSYFFAYKDDKLRRVPAQRAAAITTAALEFKKLIVTKTLEPEYAKGEPMCMDSYKYMFNNCRIAHKPSDLKATFDPIKNTHIIAIRKNKFYFIDTVYNGQQLSTKEFEQQFQRVIDDAGDIKGIPVGVLTSENRDKWCDYRDDLLAANPNNKKIMDKIESASFVVCLDDLTPFTRDELVRACWHGDGRNRFFDKPLQFIVFDNGKAGFMGEHSCMDGTATCRLNEYVCDGLARNLINHGSDHVRTDIPQPEQLQFVLNDKVEKAIETAEKDFDELIGNHEMTVLAYNAFGKNFIKKMKCSPDAFAQMAIQLAYYKMFGTSRPTYESAQTRKFQRGRTETCRSVSAESIAFVKTMEDPNASNQEKVAKLRAALKAHGQYMGQAVNAHGVDRHLFGLKNSLREGEQKPALFTDPAFAYSSHWYLSTSQLTSEHFDGYGWGQVVNDGFGVAYMIKNNALQFNVASVKDLEVHGKKYINGTHRFKQALEEACDDMRDALLAEVPAQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZH3</accession>
    <name>A0A367JZH3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000505">
        <property type="protein sequence ID" value="RCH95061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZH3"/>
    <dbReference type="STRING" id="86630.A0A367JZH3"/>
    <dbReference type="OrthoDB" id="10309462at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="142" mass="16442" checksum="50F2EB3DEC9AF70B" modified="2018-11-07" version="1" fragment="single">PNSDEYLNGIYKNVQTLVDNREFESALGILDRIQEQIQKRDNASGLDTLLVMKAETYIQMGYHNGAIPILQKAMTQSKLAYNTRNFYIAVIKLVRIYIRSKNAELKRKAIIMLERVFPKVLLMKSKDLELDLRRTYAEATSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZY0</accession>
    <name>A0A367JZY0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-aminobutyrate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_009215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000465">
        <property type="protein sequence ID" value="RCH95457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZY0"/>
    <dbReference type="STRING" id="86630.A0A367JZY0"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF58">
        <property type="entry name" value="LEUCINE_METHIONINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47994" checksum="1BFC0302CA032526" modified="2018-11-07" version="1">MSTISKLAQFGKKHIAKGIGRSTELVIEKAKGSYVYAVDGKKYLDLSTGIGVTNTGHCHPTVVKAVQEQAANLSHGQVNIFFQKPMLDLIEGLLPKMPSPKLDTFFFWNSGSEAVEAAVKLARHATKRQNIIVFQGSYHGRTFGTMALTTSKTVYSAGFGPLMPGVHVAPFPYFQQWAAYKADPKKFTPEWCGEEALHQLELVLKQRSDPKDTAAILIEPIQGEGGYVVPPDNFMKGLRKICDKYDILLICDEVQSGFGRTGKMFAVEHFGIVPDIMVMAKGIASGYPLSAIVSRKELMDQQPPGSMGGTYSGNAIACAAAKATLQVFEQEKLLENCNARSEQFFKGLRERIPALLPEGVTCDIRGKGLMIGIEFMGVPYGFASSVANEALKQDTILLTTSIYETLRLIPPLTITKEETDLALDRVVKSVAAAVKNVKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZZ6</accession>
    <name>A0A367JZZ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_006406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000461">
        <property type="protein sequence ID" value="RCH95490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZZ6"/>
    <dbReference type="STRING" id="86630.A0A367JZZ6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="861"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="882"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH95490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="901" mass="101142" checksum="08B7B24517281543" modified="2018-11-07" version="1">MSLSNDEGSQSKRQRVSRACDICRKKKIKCDGTLPICNNCQQLDTECTYKDTTKKRGPPKGYIEAIENRLQKLESYLQTIAENKDNKEDPKLKEILQELQSPLETSFGEQIKSRPQRRRQRNKLQQQQQQQQHQHQHQQSVSPPLIQSPTLSHSDIPETPTEEDDAAGQLTMDETGQVRYLGKSSGFYLLSNSRTYQNGAFHFSGYQHKVTKESAKKKYPVDPFELPPQDLSEHLIQLYFFHFYPVLPMFYKKRLTCPSCPSEPLSPLLLNAIYAVASRISPDVRVRSDLASPDTAGDVFFERARCLLDDYYDRPKISTVQALLLLASHQMGAMKPARAWLYSGMAFRMAQDLGLNRNCDHWNISPEDRERRKRVFWCCFIVDRLISAVYGRSSNFEEKDCDAPFPSVDDDEAITSSKEPSRPPASLLETFIQSIKICDILGHVLKNIYYAKAKLHTSSQYADQILTTLSRQLTRWHQNLPMSLQYKLPNTQIGEKGPDPPAPICQLHLIYYTTVILLHRSFIPGPAQSKSLVSQPCYKICLSAALSILDIVNIMLEENHLRYLYNFAVYFVFTAGIIFIKTASFGDPYDAFEAKININKIMKALDELEMTWMNAARCSNILGELAGLRDIRLESNEYVPKKEAKQPTPPPAIAVPNSPENGTESESKIDKEWNGSKDMDLPLFNSTSQIPISSVRDRRSQSPPSSDLNDRQSSSPERSSLLDITPAMDPFAAPGIMANPAQQQQQQQQSQSPFDPLSSAFWGMPTSLDTDAWNTYFGYLTGQNNNNNNNSNAPIASLLLSSTDDISSPITSSSPFMAGTPKTESRARSSMLSNSISLDLPSSPSKSVLLGFLDNGNNTNSSSTPVFVSSPTSLDPRASFESSSNNNQASKASPSNDILYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K125</accession>
    <name>A0A367K125_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000417">
        <property type="protein sequence ID" value="RCH95942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K125"/>
    <dbReference type="OrthoDB" id="2286168at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="278" mass="32045" checksum="C3C01CB93C71D3EF" modified="2018-11-07" version="1">MDNDQQNSEEASSCIFFNISREAFPVLICSCTACLASLSEQASTASATVSLFSGSEESITSVYPQSSTTDHFDTQSESFFSDYTQDSLCEYTQADNVFTAQNEMIKPFELTTRANEILLCGVKTKDLQIAIVEIWCRSGLNNNSRRLLYMAWYNWVMLDIARRLNELYRRNNGYRLVNELKQDLSRRIHFDSDLDQHPLFNVNRRTRLVYLANNFGDSICALSEFTDFMQVMEMSDLEFDRLYVDLLKRRDELSDRLNTVSGFFISNRPMGYSSPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1S5</accession>
    <name>A0A367K1S5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000401">
        <property type="protein sequence ID" value="RCH96105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1S5"/>
    <dbReference type="STRING" id="86630.A0A367K1S5"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="133" mass="15079" checksum="FBD36D787186A4ED" modified="2018-11-07" version="1">MFSSHSAPRGVLTVNLIEARNLHKEDTAGHNDPYVELWIDENYKQRSEVVKNTENPVWNQTFTFNIDEGSSKHKLYFKVIDKDVVDSDKIGSTHLDLTDIFKGTPTDTWVNLPAKLGLSSHGELHVSVQFTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2I8</accession>
    <name>A0A367K2I8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_012925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000375">
        <property type="protein sequence ID" value="RCH96369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2I8"/>
    <dbReference type="STRING" id="86630.A0A367K2I8"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH96369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="616" mass="69101" checksum="0E4819890662836F" modified="2018-11-07" version="1">MSSVIDSLKQQLQEIPEINSAEVLNSVLCLKELSGQTQLEGKWIQLTNVCKILGDAARTETVRTPLGNARVIEDLATLLQRVPSEETDFHIQALRVLGNMCFDHEDNRKHVKDSGVISTISPFFQCQKKELLPFICGFYLNSSMDYAPIQSQLSECGAAKSLIELMDPDTGITDDNCVTMCMKILDGIASNEEARKMVADTFAVKILVKRLVYELKHLEHLDMLDSLACSLLEIIMDDDILQNEIIDLGVLDELLDFLENTSIETGLAKEEKETLGEIKKAVMRLVVYALSTDSKMDELFNDQHLLTRLMKMMINPVDVVHQCAVYALGNLARSDEHCIELVEKYKLSKHLLDLFQRTENATFQYAILGCLKHLCLPKTNKPLIGNENCIQIVSSTLDQSKDMLKRNQFLSIGIIKLLCTGNYKNAVKVIDGGVLSLIVSFIKRVDDPAAKSEATRVITNVIKTIWVEEDSKDLRSKLLESDAIKPIVELVCTTQFDVLKNDGIMALNLVFSDKHYLSFMAPLFPLLTTDDYDVNGQKMSFVTSMSNDICESKLPVQIRCNICVLLCQIIEAASLVEQRDVIELIKTCCLNRLKLMKPDDVLQTYVSTLANALESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3B0</accession>
    <name>A0A367K3B0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPZ2</name>
        <name evidence="11" type="ORF">CU097_014586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000341">
        <property type="protein sequence ID" value="RCH96742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3B0"/>
    <dbReference type="STRING" id="86630.A0A367K3B0"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="211"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH96742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="407" mass="46881" checksum="D76FB3A2010EAFB1" modified="2018-11-07" version="1">MGNHQSKHKYKSRQMNKGGAVFNPPTSKFSDEYKQGSQPHPHYLQQQQQQQQQQQYRQEQRTKAYQQERYYHQQNKDEEVIEEVEQTQRGPIVLDIDACIQKLLQVGSNKNRPIGKSVCLNQNEIIAICRSAYDVFMSQPTLLELSPGVKVAGDIHGQYFDLIRLFDLCGFPPTSNYLFLGDYVDRGMYSLETILLLLCFKVKYPENFFLLRGNHESADVTRIYGFYDECKRRTSVKIWKIFCDVFNTMPIAAIVGNRIFCVHGGLSPFMQSMDQIASLPRPTEVPEYGLLNDLLWSDPSDASPDWSENDRGVSVCFGKKNVNDFLKRFDLDLICRAHMVVEDGYEFFNDRTLVTVFSAPNYCGEFDNYGAIMTISNDLLCSFELLAPEDKLNNKRVDKNSSTFQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4L0</accession>
    <name>A0A367K4L0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 28">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="28">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">CU097_013175</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36 37">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity.</text>
    </comment>
    <comment type="function">
        <text evidence="28">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="28">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="28">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="28">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="28">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="28">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="28">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 28">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 28">Mitochondrion inner membrane</location>
            <topology evidence="2 28">Peripheral membrane protein</topology>
            <orientation evidence="2 28">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 28">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="28"/>
    <dbReference type="EMBL" id="PJQL01000310">
        <property type="protein sequence ID" value="RCH97075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367K4L0"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009365">
        <property type="term" value="C:protein histidine kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF3">
        <property type="entry name" value="HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 28" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="24 28" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="9 28" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="21 28" id="KW-0408">Iron</keyword>
    <keyword evidence="23 28" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="28" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="28" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 27" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="22" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="32">
        <location>
            <begin position="615"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="33">
        <location>
            <begin position="689"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="32">
        <location>
            <begin position="748"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="30">
        <location>
            <begin position="894"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="31">
        <location>
            <begin position="1496"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="34">
        <location>
            <begin position="1645"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="35">
        <location>
            <begin position="1778"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="499"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1445"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="29">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="29">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="1447"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="27">
        <location>
            <position position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00054109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="RCH97075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1875" mass="211164" checksum="719A0887D339F2D2" modified="2018-11-07" version="1">MKAPEILLHQNIMHSTSFHATRVALSIPQDSNDPYSGPWGLKAVYNKTGSISQESESGTTESSTEDNKDDETAFDYFLHSHRVHETGPHHVPWCFERLQPFESEPEPLINNPSVQKILKRNTVVVLSREYRRKSPSSTRKKYGNDECNIDLFKKALLDQKGEKGSPYPATRRRSAWSLPVITTPCLSHKDEILVDGSSCVDVDDDNMTSNSMASSSTFLQDYDEYEQQQPSPWSQSPAPSPAIMDSEVNPFFQSPPDIDDDAFNPVSPEACYDKSSVPFPPPISNVHSIVHVPLFHPLDVIQSQVPSAKHHMNPSPIGILSFLAPIVPYPQVLLASLTSLAPFIAASLTNALQNYHMKKQSEIYRRYSSNDGNPQSADSNELPRRSSTTSTNREDDEEDEDDDDDEQSLIDLANVTPTLEKRPDHLGSMSNFTRSSLETVTEQKLTPMNEVPMNMELDDKKVLSPSSAAVIEGWGAISPTTGLPISASIPPHTLCSDKSCIKHHSSSSNKPFRERTPPCLSSNTVTDGAAASNNNTPSTDEEDRIISKTDTDYLSSSVEVKHAKRPSHHSKRARRRGRSKRHKKHAYRYYEDDGFHYHSSKNTKESLDKFFVAPKSSLLRLIIDGIPIHVFTCSPISGQVTWVNNRMLQYTGDSLKDHLGPRWLSHMHPDDQPECRKAWEVAFEQGNGFAGEYRLRRFDGVYRCFLWRIVPLRDMKGKIIHWFGTCTDVHDQHLAKESNIRQMEIESNERKYRLLAEAIPQIVFTFSPGAGLTYTNGKWNSYSGKSFDQTMGLGFMSCVHPEDRAKLQLPDLPTLQQSKAGIMWQTEIRLLSYKEEYRWFLVKCVSVDELDTGDVRWFGTCTDINDHKLLEQKLKEAHDAAQRSTESKTRFLSNMSHEIRTPLIGITGMLNFLLDTELTAEQTDYVHTIQQSAESLLVVINDILDLSKVEAGMMKLEWEPFSLVTMIEDANELMSTLAIQKNLELSFWIDDDIPDVIVGDRVRLRQVLLNLIGNAIKFTTEGEVYTKCAVDKWNREENELILLFEVIDTGTGFDADDESVMFKPFSQVDSSSTRKHGGSGLGLVISRQLIELHGGKMSCKSEKGKGSVFYFTVKFKIPTSKTRPQPHTPSNETNYDPFFRTHGYGNASMLKHHQENDDSPVTFINTKQLANDDSSRFIPSPMAHSKKHSQLSESPVSNPAEILQDVLMSKTSAMQLKPPPIRNPIAAAAAAAAANSSSKPITEAIMKASPSKQELMTPAIKPDKASSELRIPTIGTGSSLNSPKNVVILPPRTPTIASPLRALIVSQWKLSGQSMMKHVSSILSSIVSRPDGSKDHHYQIDMVYSQIEAMEKLTDPSTPPYDYIMINLASEQQILLLTKAIRGSLNQQQANALVVTTPIQRSQITESAKGREDEVIPKKCGFVFKPLKRSKLQWYFGVRQQNEMKQSNSNTTTSDTSTTLTITSNISTPDTPYKRAATQKEIFKRMNDDVGSKGYKVLLVEDNLVNQKVLTRYLTRVGLSVDIAVHGQECIDLFLKHPKSHYDLILCDLFMPVKDGYETTKEIREWEKQHLKKDEEPIPIIALSANVMSDVADKCLQCGFSTYISKPVNFAVLSDVIRTSNPAAIANPSPPPYEPHKKTPKYKSFEVYRWNPDRPTEKPILKTFKVDLNACGPMVLDALIKIKNEQDSTLTFRRSCREGICGSCAMNIGGINTLACIARIDPDISKPLKIYPLPHMNIIKDLVPDLTHFYKQYKSIEPYLKQRTSPPPDRENLQSIEDRDKLNGLYECILCACCSTSCPSYWWNQEEYLGPAVLLHSYRWMVDSRDQYGKERRERLQDKMSLYRCHTILNCSKTCPKGLQPGKAIQRIKMLMATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4V1</accession>
    <name>A0A367K4V1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000294">
        <property type="protein sequence ID" value="RCH97244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4V1"/>
    <dbReference type="STRING" id="86630.A0A367K4V1"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="254" mass="29614" checksum="266EB6BF12024BD7" modified="2018-11-07" version="1">MSNINYNTLNQSIQRHDSSYYQPILLPDPLERYGSAHLDQDIFGISVSRSTKDQQMVYPLFQWLKDSAYVWWIPLLPAAIVAAIMLWQLWTQYFQLSPRSRTVMLSIYSVSMSIAASHMISKLIYKEGILVVMMSTFGLFCLLFYTLQKKLPFSGAFPFVCSLGSICLSSLWFRHLYEMDPLEIIFPIAVSSLTCIYVILELYFIMRNVMSEDYILANIYLFVDFVYPIRFIHHFCELTDNMNVFPEILYPGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5D2</accession>
    <name>A0A367K5D2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NSUN3_1</name>
        <name evidence="14" type="ORF">CU097_005873</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000283">
        <property type="protein sequence ID" value="RCH97365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5D2"/>
    <dbReference type="STRING" id="86630.A0A367K5D2"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="58"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="150"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH97365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="354" mass="40354" checksum="A011FB209A474496" modified="2018-11-07" version="1">MSEEKGKRKGNKKEDKKKGGSKKKEKALLRETGKRNAVMTAFSKYYEAEWGSERWPILLETLKRPVRHCIMINKYAQIDQVKAKLKDTLHDLIMLDFLSIPCYASKTCSRFPPPSKDSHEITDYYILDAGSVLATEALDIQPEDHVLDLCAAPGGKTLSILQRLDKQYGRLTSNEIASDRRRRLRQVIESYLPPDVLADVSTVVGRDGTRYYGEPEQYDKVLLDAPCSSERHLLHDEKEFELWTPKRTQMNAKRQFSLLKAAVHAARVDGLILYGTCSISSLENDKVIEKMIKKGKIPVEPVKMKWAIGERTKYGWIILPDKTDGWGPLYFALLKRTGVSKEDDENSESSDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5J0</accession>
    <name>A0A367K5J0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron hydrogenase small subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_014189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000278">
        <property type="protein sequence ID" value="RCH97438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5J0"/>
    <dbReference type="STRING" id="86630.A0A367K5J0"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase small subunit" evidence="4">
        <location>
            <begin position="448"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="514" mass="57100" checksum="71E3C7134B43FF02" modified="2018-11-07" version="1">MAFSSAIVLTDLNDYIAPSQACIKPVEIQKADKDAQGPTEIKVDKEGAYYEISQDDGQEKKLEKASITLNDCLACSGCVTSAESVLISMQSLEEFTKVLEQNKHQRIIISISPQSRASLAAKYQLTPIQVQYRLVHFFKNILGVHHVFDIAFTQDLSLVETAREFVDRFREYMANGGEAVEKAIYEQQQQEESEGGRPARARGARGQSRKTGESNSMPMLASSCPGWVCYAEKTHGDVLPHISTAKSPQQMMGSLVKNYFAQKLGQAPSQIYHVSVMPCYDKKLEASRPDFEVDGIRDVDCVLTTSEIDQMLQSHHFLEMPEAPIDDMFNKVGIDPQTGQQTLLGVPGSSSGGSLEYVLAAAARELFGLPTIEGRVTVKAGKNADVCEYSLMSDDGRPVLRFASAYGFRNIQNLVRKIKQGKCTYHYVEVMACPGGCANGGGQIVPVDVNPKEWLSQVESIYRSVRGVWPEENETIKEIYNEWIGTDDIKRKTILHTQYHAVTQSFQNPLATKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5K6</accession>
    <name>A0A367K5K6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine/serine/threonine protein phosphatase pps1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPS1</name>
        <name evidence="5" type="ORF">CU097_003680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000304">
        <property type="protein sequence ID" value="RCH97131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5K6"/>
    <dbReference type="STRING" id="86630.A0A367K5K6"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="473"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="534"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH97131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="644" mass="73968" checksum="42104286D4FE97AC" modified="2018-11-07" version="1">MSELFEIPEHLLTLTADNIFTCTPHNYAKIQDQYRRFPLPNDILFPWLHGVDGRSHQQNLFFRVRRSLVPKYRGIMLIHCNPLVHAKRLIDSVTPLEVLDEQGQFLNKSTMDTSINLRNFENQVRRFATLCDIFLYGERAHEVAPLVAMAQNEFYQERLDQADQITRTAGKRAAAEANLIKYKTIIIQDEFQVFEKEYPELIMYDSDGVAKRTLDFFELEGARMREMSAASQVTPGVWAGNTQDAPISTNDITPEDTAATFDSNPHQFSICIECHDLGEIPAPSVLMLARETLNELKDGAMPSEIVHLDMYGTGMPATKTDFDTFYARLVQLLMFMEDQVNRNRQILIHCSDGYTESSTLVLSWIMYRLKLSLPEAYLYLQERRSFFVYAADLPVLRRIEQLLKDEPAEPVPKRRRSEAYENMRHLSIEDSSSHSTPCTVVTGQCVQKTQLSPTPEELQEHPWMFSPRFEGSFPSRILPFLYLGNLNHATNAEMLKALHITHVVSVGENAGLQTKGFELLLLDNLYDDGIDTIRERLDTVIQFIDDARQKGTCCLIHCRVGVSRSAAVTICYVMRHLKYTLVQAYLFVRARRLNVIIQPNLKFVYEMLQLEQKETGTISITWPILCKEIHQLNLTYKESSSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5M6</accession>
    <name>A0A367K5M6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARC19_2</name>
        <name evidence="7" type="ORF">CU097_014967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000275">
        <property type="protein sequence ID" value="RCH97465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5M6"/>
    <dbReference type="STRING" id="86630.A0A367K5M6"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH97465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="169" mass="19673" checksum="80D09AD8A2641575" modified="2018-11-07" version="1">MSNTLRPYLTAVRSTLTAALCLENFSSQVAERHNYPEVESSKSKEVLLNPLIISRNENEKVLVEPSVNSVRVSIKIKQADDLERILCHKFSRFLMMRAEHFVILRRKPIDGYDISFLITNNHTEQMYKHKLVDFIVHFMEEVDKEISEMKLSVNTRARIVAESYLVQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5S8</accession>
    <name>A0A367K5S8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CU097_014831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000271">
        <property type="protein sequence ID" value="RCH97518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5S8"/>
    <dbReference type="STRING" id="86630.A0A367K5S8"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000276">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH97518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="301" mass="34840" checksum="D9327D3A7779FC27" modified="2018-11-07" version="1">MKKKEKVLLMGKSGSGKTSMRSIIFSNYIARDTRRLGATIDVEHSNVKFLGNLVLNLWDCGGQEAFMENYFASQRDRIFKNVEVLIYVFDVESRDWEKDLHYYQSCLEAILANSKEARIFCLIHKMDLVPEHQRDQIFEQRVTELQKRSEPLSIQAFRTSIWDETLYAAWSKIVHCLIPNIRILESHLNNFCRICDADEVVLFERTTFLVIATAATIIHQDHHRFEKISNIIKQFNLGCSRSQTRFKSMEIRGSSFTAFIDVLTNNTYVMIVMSDPNIQSAATLLNIAAAKKHFEKIEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5Z0</accession>
    <name>A0A367K5Z0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_014507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000267">
        <property type="protein sequence ID" value="RCH97559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5Z0"/>
    <dbReference type="STRING" id="86630.A0A367K5Z0"/>
    <dbReference type="OrthoDB" id="538249at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048641">
        <property type="entry name" value="RlmN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="23S RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544:SF5">
        <property type="entry name" value="RADICAL SAM CORE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21016">
        <property type="entry name" value="RlmN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="126"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="809"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="588"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="883" mass="93846" checksum="013FCBBAF14DECB3" modified="2018-11-07" version="1">MHNLSRQFIRQFKRHYAAIQQQATDHKINLLGLTLDELQEEIATVPNVKPYTALQLWQQIYQQGHTQFDEMTNLSKELQNSLSDKYKVYYGDIKLDKIARDKTRKFLIGFKKNQPRAMVETVIIPEPTRSTLCVSSQIGCSLNCSFCHTGTQKLERSLTAAEVLGQCMIAAKQSGDFPIKNKRTVSNMVFMGQGEPLYNWKQVSKAIKILTDQRGLNWTKSKITVSTSGVVPLIPKIATELGVSLAISLHATNNDLRDVLVPLNKTFPLEMVLDACKEYAQNMGNKGRRITFEYVMLKNTNDSLSEAKAMVNLLRQLPSHVNLIPFNPWPGSGYESTSMDHIEKFANLISNSGIHCTIRRPRGQDQPATSTPAFGFGTQQANTNAGAFGQQSGNTFGFGTSQPATAFGNANTQQPQQSTGFGFGNQQNNATGFGSGGIGSTTTNTGFGGFGNTQQSNTTGFGMQQPNTTTTGFGSTQNTAFGGSGTNPPAFGSTQNTAFGGSGTNPSAFGAVSQPASNTAFGATSQPSNSFTFGSQTNANPTASSTTGFGFGASQPSSTSSGFSLAAPTTSNTPFGTATSQPAAGTASFGFGTSQPSTSTTSFGFGTSQPATSSTGFGFGTSQPSTSSTSFGFGTSQPSTSSTSFGFGTSQPATSTSSFGFGTSQPATSTSSFGLVTSQPTATTTSFGLGTTQPSTGTTGFSFGASQPANTTNTFGSFGTSAQVNTQQQQQQQQQGQLLDLRNCFPDTNAPHFVIRPDGITRSTIAPNLFFGATPKERVLPGGYTSISAIPSSVSAPKPKELPRYLTSGLISPAGASGVNKRNKTDELMSKQESTEKKPEESKQNIQLYVTDTNNQQKGLFNQKKTDPYQGFYRNLRNDTAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K752</accession>
    <name>A0A367K752_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000232">
        <property type="protein sequence ID" value="RCH97998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K752"/>
    <dbReference type="STRING" id="86630.A0A367K752"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005089">
        <property type="entry name" value="CBM19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03427">
        <property type="entry name" value="CBM_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="207" mass="21948" checksum="779350990A6D2DA5" modified="2018-11-07" version="1">MYITYDDPQSLNIKVQHAMCEDLAGVMVWDIHQDNGELLDVVNKVHEPVDRATCQSHLAAPKSGNPLFTPASSSASTPSPTSVAAVSPEQPDEDEYSDLDEWTVEASPEIATPVATASISTKATPTEEILSIQTVDSPLMTVVSTAPSQAVPTSFGSLSGGQGCSVPGQQKCVHSGHSPTWVTCNFGQWLERECSAGLVCVDDQGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7B9</accession>
    <name>A0A367K7B9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcriptional regulator ATRX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_013460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000223">
        <property type="protein sequence ID" value="RCH98104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7B9"/>
    <dbReference type="STRING" id="86630.A0A367K7B9"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="113"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="501"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH98104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="85948" checksum="9B9E86BC480486B0" modified="2018-11-07" version="1">METIDVDNTWSSYKKLDLTLDSIQLLNPLDLPIDTSKDNANLFTINNKKRPNSSSIACLEELQTRSKRIKRFEESASEEKKAQLLTRLEIPLNDYFKSRLKYHQLEGVEFMWKRVYKKKAGCLLSHAMGLGKTIQTIALLTTLYEHLHRHPEVAYPTGKRVLILAPLITLSNWVNEFRKWNVDGFSANLGQIFNFGEMTPESRNKRIVYLKYWYTNGGVMLMNYDQLRYLLMRSSRVDDEYYRYLINPGPDVVVLDEGHRIRNAGSQLYKIVSEFRTLARICLTGYPLQNHLLEYYHMLEFVAPGILGPQETFKAYFTFYIERSYANSPPSIKQKAAIRLYTLQLLTEEVTHRRDALTLQEALPFKTEFAITFKMTDIQYEGYVNALKSIERESSVISNLLLLRTICNHPKILQKLLSNRESKRREQFYINNNDNSDTTYMDEQSVEETVDEVVTPAVPGEVEEEELIGLDINMFDWATDYFKNDGIENWNCSNKMSFIVDLATECSVIKEKIIIVSHSLACHDYLQHLFSVLGIGTLRIDGNTPLKLRQVILDDFESDESKLIMLLSAKAAAIGINVTSANRIVLIDQDWNPLYDEQSIGRIYRYGQLKPVTVYRLVTASTIEERIFAQSVHKKSIARRLIDNKTSMTISKEELKEYYIQPSLDLPAIDINKVRKELNPDFITYSALLKIKDHITDFKLHDMDNVEEYDPYVKLSAPQRREAVSEASRLLKEWKRQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7H1</accession>
    <name>A0A367K7H1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HDHD3</name>
        <name evidence="2" type="ORF">CU097_011582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000222">
        <property type="protein sequence ID" value="RCH98117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7H1"/>
    <dbReference type="STRING" id="86630.A0A367K7H1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="509" mass="58190" checksum="973C3DD268601DFC" modified="2018-11-07" version="1">MFKHIIQKKKEQTINKRKSIENIDDAFKDMVCKDCQETGHANKSYYKCKYYKEASADDVGTSAGRKRKQSSGVKQEKQKAKRQKTAASSSSVICTSCKQTGHKSSRSPDCSNHMLSKNEVFSRNLGQQFKTFTRKLPFDQCVHSSYQSALKSRIVSACEDTRQVVFRAQLFINQYTLNLKVHSNHIFKQNFWYSICQLVMDKRATNSAALPEGLLENWNLFRQSHRSIIYTKNLASETSRCLSEACVQLATVYTNCIVENFEARLLKYLSYLIQNTFVSMTYQDVKKIAYDYCYQSVCKGEPKWPQGATFTQETKTTVDEACLPLQQLITKQVEEAARYGIKVTKNEITDHFGQAYRKQQLKAPFYGIKQGMTPQEWWKELVYATFSSAGVHPKELDPNFDQLYNALYNRFTTAAAYSIFPDVVSTLEELKTRGFKMGVITNSDERVAKVVENLKLDKYFDFVLASADVGYEKPDKVIFDRALKIAGDVSAENALHVGDDLNKDYFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K990</accession>
    <name>A0A367K990_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_014533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000174">
        <property type="protein sequence ID" value="RCH98748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K990"/>
    <dbReference type="STRING" id="86630.A0A367K990"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH98748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="592" mass="66921" checksum="5C30366909AA8699" modified="2018-11-07" version="1">MSNIKVLVTGSTNSQFRELFAKAQQINEKYGPFDMHLCVGNFFAPNTANEIIEDLISNKIEVPLSTYFLMGETPFPPSVQQRIDSADGEVCSNLYYLGNRGILTTSQGIKIAFLSGVQPKEEQEENKDNDTHYTKDMVDKLCQTKLPATLPPGVDILMTCEWPKNIKELSAVSVDMDDSKASLYVSQVAAALKPRYHFAASQNVFYEREPYKNILSGLGGRDERLAKHATRFIGLGDAFNTEKQRWFYAFNLVPMSQAPSEALETVPENTTECPFSSLFTNKRRHEDDHNGAFFWGEEPKRPKMGAEVPKGNYVCRRCNVPGHYIQDCPMSAPKQPPEGYVCNICKEPGHFIAQCPQRQQRPPPGEQPSLDSCWFCLSNPKAEKHLVLSIGDELYAASAKGPLFSSRDNECRVPGTGHVLIIPVTHYPTFGKIPLDSQVEVIAELEKYKSALRRMFEKYDHDMITFEISRESFRGMSHAHVQVIAIPKGKCDLVEQVAREQGQAFGMDFIEQLPDNPAIPYFKLELPDGRTLVHVIKPKERFNLQFGRLVVSHVLGKPEREDWKACQQTEEEEKKEADSFKAAFKPFDFTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9I7</accession>
    <name>A0A367K9I7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PGA5_1</name>
        <name evidence="5" type="ORF">CU097_003280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000168">
        <property type="protein sequence ID" value="RCH98820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9I7"/>
    <dbReference type="STRING" id="86630.A0A367K9I7"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016669724" evidence="3">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="49"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH98820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="427" mass="47402" checksum="4AB95D96700734DD" modified="2018-11-07" version="1">MRSAFLFYLGALALSTTVEAIHKIPLYQKRTNQPEFISAPAQPVQNGMMGAVIEVGNPPQELTLALDTSTGFSWIRGTQCVNENCLDRKSYDASRSTTVVTVGKKFTMDYGRGIAYTTLCLDTFRYAGLTVENMPFGNAYRMERFDKGFDGFLGLGRNIDLNSVQEHYAKRDIPDSGFVPNAYQQSYGMGSSQFAMYTTSSQSGFSQTTASNSTPSTGVASGGWGTISKRHTNDDTPAGYLVLGGVDTDAIQGKLYYVKAAENDGSGNWAVPVRHAKFLHNLCFKVSKHAKAVLSSSTDVIGLPNKQADEFEKHWYAVYDEPDNTYKIPCCLMDRLTSFQIQLGNITATVPPHYWSYPRETDTCCDMCRTHIGRSGSDSDYVLGFSFTNAFYTQFDIEKDRIGLAIKKHHKHDGLELQCNLDYFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9K4</accession>
    <name>A0A367K9K4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">POX1_3</name>
        <name evidence="21" type="ORF">CU097_010893</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heteropentamer composed of five different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000160">
        <property type="protein sequence ID" value="RCH98922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9K4"/>
    <dbReference type="STRING" id="86630.A0A367K9K4"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000018">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="19">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="18">
        <location>
            <begin position="163"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="20">
        <location>
            <begin position="303"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="17">
        <location>
            <begin position="514"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCH98922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="714" mass="80711" checksum="1AE857BD97612793" modified="2018-11-07" version="1">MSNIQNRLEAVKQQLSPEQEYQNAVDPIRSMNEERAKAAFDIRSLTYLLDGGEKNTFLKEKIMQELERDPLFKMDDIFDLTTSEVRERTMAKFRSMLHHLQNEPVDQFKKRMEIVSLVDPGFWTRFGVHYGLFVGALQSNATPGQLGYWFERGALSLNNFVGCFAMTELGHGSNVPGLETTATFDEASDQFIIHTPTLTATKWWIGGAAHSATHAAVFAQLIVKEKRYGTKCFVVPLRDPKTYNLLPGINIGDIGKKMGRDGIDNGWIQFTHVRIPRGYMLQKHTKVSRTGQVKEPKLQQLTYGALLQGRVTMVADSGHVSKKALSIAIRYAAVRRQFAPSGANGIETKLLDYPIHQRRLMPLLAQTFAMLFTGTEMTEMYNSMMARLDGAREGDQDLDEVMEMLKETHSTSAGLKAFCTWNCLSTIEACRQSCGGHGYSAYTGLASMYQDFAVQCTWEGDNTILTLQLGRYLISSYREALNGKKLSPGVGYLNNLNKLIGKRCNAKTLEDVLDLDTISEGWQVVCAHVVKNAATEFEECLKRGLNADDAYEQCSQARLYAAKLHSFSYLFNRFADAVKKTTGSLHTILRKICLLYGLYTIEENAGAFLQFEYFTPAQIEFVRASVNNLCKEVREQAIPLVDSFNLTDYIINSPLGRKDGNVYVHYFEQVKRSNPQSEHPYFDRLIKPLIQRSTEENDYEEELAGLEDDDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA04</accession>
    <name>A0A367KA04_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000151">
        <property type="protein sequence ID" value="RCH99044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA04"/>
    <dbReference type="STRING" id="86630.A0A367KA04"/>
    <dbReference type="OrthoDB" id="2290856at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="353" mass="41683" checksum="65C0B041C914BD83" modified="2018-11-07" version="1">MSTKENNGQKEDTTQEDPNRFQSVDDQKLREYNDNSHTPLLSKSLSAQTNSSASSNSRRMRPDNDFAPKKGKRPYPMLRVDQLSVQDIQAILMENYSLRQEIEIMSHQFHVERMNLQRRLRHIMARNQYLEEMRWSSKKRHRQKQESLAEDLRKHLPERRKSFSDVDGSGPVYRDDHPYLVYRDMRPFDDGYYNDDEDEHPESMIDQDEELDDNDLDDDNVRYYKPLKHHPFPLSHPPPPPPHPNFGPMPPPPPHHIGYPPPHHQHPPPQPWMMNDMPYDLPPLYRKRSKSKGRFIPNEDEHHENEESILHMMHQMALGPPPPIPMPPPQSPLVPPMVSIHNNNRRRKSSSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA27</accession>
    <name>A0A367KA27_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000153">
        <property type="protein sequence ID" value="RCH99016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA27"/>
    <dbReference type="OrthoDB" id="2279273at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="182" mass="21062" checksum="F597AA4683EE3B78" modified="2018-11-07" version="1">MPMINPAPLADIPSSIVKSRSSCICNPVLSFADDAAIGAVAARYLDDTICLWSLRYEHEERLYELWLERRLLLEPGFEKLTEELLNLINFYWSMKVNLQQKNSANEEYMINDFIPYKNLLEEAVDAILELQEEHKKKLGLYRFTTPTKETLDIVVNPSILKLTEEYDKAGMHHLGPFFTSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAV4</accession>
    <name>A0A367KAV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_011973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000129">
        <property type="protein sequence ID" value="RCH99345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAV4"/>
    <dbReference type="STRING" id="86630.A0A367KAV4"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="204"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH99345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="42095" checksum="887674F797E8D3B9" modified="2018-11-07" version="1">MHRIFYSKYLNEIAAQHSPSAIAQHRENAQTIGWIHSRLSPPAEIKTLQDVKHLIFNHEFYRLLMVLAWLLLGGLIEIFLAQLGDMRYFAMPATSKHPLIDLLHDVFPRVENFQIVNYLLTCCVAYTVIGFAIQSPDWSTRFTLIRRYTFILGCLYIFRGITLLVTTLPSSLVDECKPPETELTGSVGERFGFIYKVVAGSAFGCTDNIFSGHTSVMMSCVLLWRAHSRLRRPFSWLLYLIAFIGMLMIIVSRFHYTIDVLLAIFITYTTWNIYLQYIREASIRYIFGFTKHAAFDVFNTMMVDGAQTYQYLAWQPHALGQDWLMHLCMYVDGLDIKLRTMGVLDEEGEWRPMMNQSSLTKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCI6</accession>
    <name>A0A367KCI6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000116">
        <property type="protein sequence ID" value="RCH99541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCI6"/>
    <dbReference type="STRING" id="86630.A0A367KCI6"/>
    <dbReference type="OrthoDB" id="2285740at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="690" mass="77505" checksum="3784029AB20E7C23" modified="2018-11-07" version="1">MRNLFDIGKERKSLKLVKKLQEEAEIEWEKELARRREQELNDEAIAKALQDELEREETTNRDASNPFTPSINPPPLPTKPREYNPHPLDSSDHTTSSQSISGKSRSSVSISPLYGISNRNSSLPSKSYLHYKPGLTMQVTSPVVSSNVFNTPAQKPSTLPTSSTLSSTATNNSKSQPRPTSSSSLNNVQPAQNPPNNNKTNTPVFHTPMQASSSLPTVHSPPPPLSSQKKKQQPTASINQFHVPPTNNNSTNQHHMPQPHPTQTHPSAIDNTAQIQRPPVTPISYPKKEPYHIKTNNPTTQSVPLALSMPEPYAHSIRTQSEPIALPLSQPQYIKSVEPVQTHAQNMTTPYQPKQASVHPVMTLNASSPYYKTSDSFLSLKPNQEEKFEQGVPLAPKKTIIDDHGDDESSASSKYDFSDMVYVKNSKKMMAESSDNPFDDTNAVKEIQIVDPTLHIYPLATEEKVEQKNEAVVVTSKEKTEQTWTRGYVEKESTERPYAEKESTERLYAEKESADRSYAEKESKEIEPVRPLVRPDDDDDDKPPKQVFPTNILRAGAPVPSNEYGYYSVDKDLPTVPQSANKEDRHITVASVNPGQRVWIRIHPTDTGKTLAERIHIVATYQTRKVTKITTKNGRNIPLDNTPLFADWNEILSFEEGEPWTVEWTYMDHPYLEKLAGGKEWVKHLKSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD86</accession>
    <name>A0A367KD86_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000100">
        <property type="protein sequence ID" value="RCH99791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD86"/>
    <dbReference type="OrthoDB" id="10286628at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22908" checksum="1AB1FDFB9136436C" modified="2018-11-07" version="1">MQSITSYNPSRGITDDRRWSSISVVARRRHSINKRNSWKTRQKRRTFPPAIQNKESDCLKQKRKKRNNGLSLYWLDGNPIFQLPPTMSSQSSSLPVAVKPPVPDRFSAICVDLEGNTVKTVYRSSRLDEVTLVYVEAGLFLFGFLFFPCWWIGALLFFKHRHIFTYLNIAFTFISLCLIVVLVVLLVWLSKEPVFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDK6</accession>
    <name>A0A367KDK6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000069">
        <property type="protein sequence ID" value="RCI00278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDK6"/>
    <dbReference type="OrthoDB" id="10319195at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="186" mass="21014" checksum="5821267D0047C99C" modified="2018-11-07" version="1" fragment="single">QMKEKIKEYDNLLQQKPTTHVTALSTQDAFLGLKARFDKLVSEHSQVEAPGKDSLIEQIRYVVEQLRQTIGKLNTAEHVNHRLQNFKSNSAHLNEEEFKQAFTLNESIEVFKNDSVLLAAIIRRLLETKQETVSDLTEYTKAFAEERQITTKASQSIYLLVAAGLLESDRSQGESVIKITAALNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDP0</accession>
    <name>A0A367KDP0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TatD DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TATDN1_1</name>
        <name evidence="6" type="ORF">CU097_006928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000070">
        <property type="protein sequence ID" value="RCI00261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDP0"/>
    <dbReference type="STRING" id="86630.A0A367KDP0"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000040">
        <property type="entry name" value="Putative tatD related deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI00261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="303" mass="34856" checksum="F0DCFFBEF66D62BD" modified="2018-11-07" version="1">MRFIDIGANLTDPMFRGIYRGKQAHADDFLQVIHRAKQAGVQKLFITGTNLSESKEAIEYIEKGFLYTTVGCHPTRSNEFEEHPGGPDDYYNKLAELTQHKSVIAIGECGLDYDRLFFCPKDVQKKYFERQFDLAEKTRLPMFLHNRNTGNDFFDLVKANRHRFTTGIVHSFTGSMEEMKKLVELDLYIGVNGCSLKTEENLQVVKEIPEDKLVIETDAPWCDIRPTHASFKYLQNVPKEEMALYSPPSKKKERFEMGCMVKSRNEPCTVGLVLHIVAAIRNANPNELSEKVWENTYKAFNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KES4</accession>
    <name>A0A367KES4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000047">
        <property type="protein sequence ID" value="RCI00667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KES4"/>
    <dbReference type="STRING" id="86630.A0A367KES4"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="73"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="659"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="687" mass="77706" checksum="B102F2318A10B371" modified="2018-11-07" version="1">MSATLSRLPLIPLSPLVQTSIDSAKYLAAITQNLSEHPDDTRLQKHLSSTREKLDQITKHTQTIQVSFLTQFSTQEIAQEIAYINSQLFQLVVLDSTWIANYDKRVNVIPMLDFHRYLSHAFAHEVICSSSRSDVNIVAHLIQIATTLLFVYRDFSGCTAILKCLQMPEIQRIENVWSQCPPKMIKMFKELLPLISPDNQYEVYRQALWSLTHTFLDIPPMQSRMVAIPFMHAHFQVIQTIPSTVQVLEFCQQLTKIDPSLLGPTTSSVKFTQDLKRPSVDLEKLHTNPAVYHWLVSRAYLTYAQLRCESLHVIPLTAGERLPEIEEEHDMYWKFFRLEEEEEEENDEALKGVEMKLIKTQEDITDQVQVPSSSGSNNKVDDSHSHTAAADDDDDAMEIVDTESLVIESNKFESTNEIDKVDESNTRTQQDNQIIATKEMAIPDTASQNNTEEIETTSDKAQQESLPIKENTVTKEEEEEEIALKDDASSISSNKKPGDREDAYHSEESINNTSKLSSEEFECIDQSASSTNGISTESDIVAFDKDDTNDQNLTASHTTPDPAPTTTTTTTGISPEEDENDEEWTGYPYDDSAKEQDDEDEEWTGYPVSTPDEEEDEEEIWKGYPAPEQHIIEECNPSFVPWDKRGQLQAIGKAAARRMQHSLSSTAMTETARKRLPSSFGQSSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFT1</accession>
    <name>A0A367KFT1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Karyogamy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">KAR5_1</name>
        <name evidence="13" type="ORF">CU097_003009</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000025">
        <property type="protein sequence ID" value="RCI01093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFT1"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016969230" evidence="12">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI01093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="483" mass="56608" checksum="9EC59829CC4284EE" modified="2018-11-07" version="1">MSPALILIIFLLLIEPSLLIKEKLFKALQNNENDCYKKATLELTKGCQSLEGDNPVDNMKYAVMLTLCELLSAKINIPSECNIINTHQQVVQCTQQLSLSPQTWTTYSGYFRDIVLICFAIKYPMEKEILERLHENITLNQVKNFNILSSQQRYLIQWREEEFKRLDKLKESQLNIFEHVEKTSMYYQRMAHQVELLFETLVLLQNQTELSILQYNDMVSRHVEQVQMLLQDSFLYQAMKIDETLDSLLTKSNTLNQHVERILLLQEQTVQSWNLLTKNLERELTDVWNQSIYRMSTGFHLIMNQSLSEAKLLKHDLTLIHRQVKDTMEPFHRLSNLISGVYFQGVHTMKRLIVFVVSCALLCLRIQALLKQMNVHRNQLLTFVLLIVTSITCQQAHLNTIFTAVLLAITSIILEGIILYHEHKKVSAEVLDRPEIKPLDYTQSKTDIEIRLQKVPNLDELSPPPPYQAKDTYYYHRYYYHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGI4</accession>
    <name>A0A367KGI4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000017">
        <property type="protein sequence ID" value="RCI01287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGI4"/>
    <dbReference type="OrthoDB" id="2238774at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="147" mass="17354" checksum="4ABD757ECF8E451B" modified="2018-11-07" version="1">MEEEEHELTRIEKIEHEHKLVQRKFHKRNEPEKGGYATLSDYWKEFGHVVQHTMHLKSSSSIQLLLNLTGEFHDVCDAYERDAEIYEYKECFDALDFAWQTVIEDHQPISQTDKVRILNVLRDGQDRASLFGLNQVYHHATELLDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHD0</accession>
    <name>A0A367KHD0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_015872</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase C19 family. UBP8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="15"/>
    <dbReference type="EMBL" id="PJQL01000004">
        <property type="protein sequence ID" value="RCI01578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHD0"/>
    <dbReference type="STRING" id="86630.A0A367KHD0"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="81"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="217"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI01578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="547" mass="63327" checksum="7DD4B65EAEAF9A2F" modified="2018-11-07" version="1">MTHIPDSSLSPLSPPSPFQHPDQKTVYDVIYADSNPSHFYGESHLIQTGACPHLTRIKQKYKQEGEDENSILENYRSLIQYSISWHKSKQEIEKKRKHRKELPFPKCSVCSDPLSRLHACLHCVFMGCWRKGHMREHQMEKEHCFAVDFDRHTIFCYECNDYVYDVEINEKITKAEIVSSRSRRKKQRVQYALWEPTEKDISTIVNNSVIASCQGLRGLCNMGNTCFMNVILQSLVHNPILKAYFLSDKHNSKRCKRQHCMCCEMDDLFIQLYSGNKQPYGPCRFLQTMWMSLKELAGYAQQDAHEFFISALNNIHAGCEESKLSNCECIIHKTFSGLLQSTVTCLRCKNTTTTYDPMLDISLGLKAPEKKKKHLGNGRRHSHEDRRHGNTLADCLERYTQPERLGTNVYSCSKCGNTFQEATKQLSIKRIPPVLSIQLKRFEHSTSISKIETKIKFPVDLDLTPYTASKNKNSGNVYTLFAVVSHHGKVDTGHYTMFAKHRNEWFKFDDHSVTFAYQKDVLDSKAYMCFYIKKSLEFSDNSLQSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IK31</accession>
    <name>A0A367IK31_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005470">
        <property type="protein sequence ID" value="RCH78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IK31"/>
    <dbReference type="OrthoDB" id="2278008at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="21130" checksum="4E8268F70D29B915" modified="2018-11-07" version="1" fragment="single">VSDDEALDRFVRELKDDVRIHVMTKDPRSLEEAIRFAIAYDSAKQTGMFIPTNRQDQIPNDPMDLSVLMQQFNAMNITNNGHHQRERVPIRNNRNIICHWCKKPGHVIAECRTRLHEIKEFEQNRMRQNRGNSRQQFNRQRDYRQYNNNKVYNADLIEIEPSNDNTNKTRSNFASIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKG3</accession>
    <name>A0A367IKG3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_000696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005370">
        <property type="protein sequence ID" value="RCH78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKG3"/>
    <dbReference type="STRING" id="86630.A0A367IKG3"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="62"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="144" mass="15605" checksum="5F18F0FE02FBDC1B" modified="2018-11-07" version="1" fragment="single">AKILLSSDSSNDINNERAITLLGDDAAIQHAKHLIEELVYGSPNLSTPRFASYGLGHTTNPNDQRIYVPIPSTVVGLIIGRGGETIRYFQEQSGARVKVDLSGDPNAEERNVCITGEPQALAVAKRLVEEKVAEANPEYAARYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKS8</accession>
    <name>A0A367IKS8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005280">
        <property type="protein sequence ID" value="RCH78287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKS8"/>
    <dbReference type="STRING" id="86630.A0A367IKS8"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="130" mass="15050" checksum="D5857610416DF47B" modified="2018-11-07" version="1">MIAMDNIGYYGLVIDGRYVQATFGNPDSFIPVYGQSEYAIPVNSIEGFKAYWEKSSYASQYSPAIEAEKKRREEELRQAKEEERKRQEQYKASLENDLTAFFNDMSDFATNSENADIFSVPKNETEKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMK9</accession>
    <name>A0A367IMK9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004820">
        <property type="protein sequence ID" value="RCH78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMK9"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="10848" checksum="DD5562E97F7CE5BA" modified="2018-11-07" version="1">MDDSIRNKLLPDIRLTACQNLVNNSATSTSLKIHGVNGDIFSMSSAKGSAATSVVAVSASVSDATSVVLMVTFAVELMVSDDMAVVGVGVMATVVVMVEEGVLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN33</accession>
    <name>A0A367IN33_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004704">
        <property type="protein sequence ID" value="RCH79100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN33"/>
    <dbReference type="STRING" id="86630.A0A367IN33"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="210" mass="23848" checksum="461526957FFC3B66" modified="2018-11-07" version="1" fragment="single">MFDKSEKFPDGWFFIKNHSNGYVLMVDNESQEVGSPIVLSSLRTKDYSAQLWRYDPSGYLVNKKSGQVMDVAKGNAKAGVDIVQQIQSKDVKEENNYQKFGLSPHGHIYLINKSNLVLGIKESFFARREGLHVHLQLIDKRHLDKKEQRWDFVLPVIKEKTEPVKRSISTFSNTSNSKLSAVAQIKEDDARSVRSSTGSVTSIDQDEANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IN49</accession>
    <name>A0A367IN49_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_001676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004727">
        <property type="protein sequence ID" value="RCH79063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IN49"/>
    <dbReference type="STRING" id="86630.A0A367IN49"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH79063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="228" mass="26069" checksum="D39555C865F500F1" modified="2018-11-07" version="1" fragment="single">PFKCREEGCGKSFIQRSALTVHMRTHSGERPHVCEHPHCSKSFSDSSSLARHRRTHTGKRPYKCPFDGCSKSFVRKTVLTKHMKTDHVLTGRKPSVQWQPFIEERRKLMLEQQQMQMQQQSMQQPCACTGCTYSPQQSTAPLHWSPPTPALSGYESPYSTQDDTSNPSSPITTSWPYAAPFQHFPSNMQPNWSLPDIYDQHVVLPSLSSIIPSKDDWFLRRDSGVSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INH3</accession>
    <name>A0A367INH3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004626">
        <property type="protein sequence ID" value="RCH79232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INH3"/>
    <dbReference type="STRING" id="86630.A0A367INH3"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="31873" checksum="B743B775DA56A40A" modified="2018-11-07" version="1" fragment="single">MAYDNHDALDTLSSTLQSSSINDHCLAAKPIEPAELGNKLNHIPPPLMIDMRPLVHFEKSHIRHSINLDLPTLLIKRYQRRGNVAQNFNLENFITTHEGINYFKQWIDQFSGDYVLLPKEATVVVYDDHMVDSSTCWTLMSVILNSGSSKNVYWLHHGFSAFRDWDTQGKYLSDSPSPAFSKSTPTKESGTPMQRRASLFSLDTRCHSNSRRAQQDKTKEEVTMADDAFIITEVVSNFLYLGSEITSPEQLDILKSRSIRRILNMAEECDDDIPGLKESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INS4</accession>
    <name>A0A367INS4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CoA transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004550">
        <property type="protein sequence ID" value="RCH79360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INS4"/>
    <dbReference type="STRING" id="86630.A0A367INS4"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF6">
        <property type="entry name" value="L-CARNITINE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18118" checksum="67DAB5D27D340942" modified="2018-11-07" version="1" fragment="single">LLPAPFVDPFLDIMAQSDVLIENFKPGTMEKWGLGPDHIYPENPSLIYTRISGYGQTGPYSKKPGFASVCEGVGGFRYVNGNPGQPPVRPNISLGDSLAGMHAALGVLLGLIARNKVKNQSRTGQVVDVSIYESVLNMMEGIIPEYDRFQQVRQRKKRVREEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP88</accession>
    <name>A0A367IP88_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_001660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004492">
        <property type="protein sequence ID" value="RCH79449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP88"/>
    <dbReference type="STRING" id="86630.A0A367IP88"/>
    <dbReference type="OrthoDB" id="2202626at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="2">
        <location>
            <begin position="201"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH79449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35804" checksum="D8FB179DB7152BC1" modified="2018-11-07" version="1" fragment="single">MFTDKKKIEKFNAEIIARVTTFLDLPSILQLTLTSKSFCHLMKDEFVFKRLVERDFGITDKKPEESWVKIYKQLKTGNDQTTTMNGNDCPHHLDYPEATSALIIEIKRVLYKSYQQNPSLCDICQTQNATYLNMHPGCHSEACRTCLDNFVDDEEHYPIQLELDTGNLYCFQCTQGQPYKIDGSSKTSAILSSLNAPESDQELDLRRKAEHLLYIQELRREEMSLKHYFVEKQWGRLWMLFRTREGSPLPGRVTNNKLARSNGTLDPNIRLPMDKYRPSPETHADIVSVKLWRYLEKAYGVQGKAYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPC1</accession>
    <name>A0A367IPC1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_000758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004456">
        <property type="protein sequence ID" value="RCH79503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPC1"/>
    <dbReference type="STRING" id="86630.A0A367IPC1"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF127">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="6">
        <location>
            <begin position="79"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin carboxylation" evidence="5">
        <location>
            <begin position="160"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH79503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="299" mass="32755" checksum="172E5748D8A85521" modified="2018-11-07" version="1" fragment="single">MAQDVSVGFYEDSLSLAAKLPSGSTYSIELDPLAHKIIPEESTYKVLSTKIEVKLKKKVSGIMWGALEGENDLGTPVPAVTNNKKQTKDWNKLIKEVDDEKLEGEAAVNALFQQIYRDADPDARRAMMKSFIESNGTCLSTNWSEVGSKKVETKPPEGTMVKKVLIANRGEIACRVIQTCKRLGIPTVAVYSDSDQNAPFVRLADEAYHIGHSIASESYLNAEKIIQVAKRSGADAIHPGYGFLSENPDFADMVNQAGINFIGPRAESIRTIGDKMAAKVFIREHLSSIPLIPGYHGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRM7</accession>
    <name>A0A367IRM7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RFT1</name>
        <name evidence="11" type="ORF">CU097_000037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003961">
        <property type="protein sequence ID" value="RCH80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRM7"/>
    <dbReference type="STRING" id="86630.A0A367IRM7"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH80354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="526" mass="60062" checksum="1C8CF4B41C94E3DE" modified="2018-11-07" version="1">MKNKRESTPTSEEGDLLSNTAKGASYLILLQFISRMLTFSLNQVVLRYTTPDAFGIASVNLELLASTILFISREGFRAVLTRSTKNQQQIVNLAYIPACLGFMTTTLCCGYYLSTISSKEADIYPYYRTSVVLYGLASLFELIVEPLFIVALNKLYFQLRVTVEGTAVILRCLVTFALTLYGYSILSFAIAQLVYGLVMMLGYLGYFLYKEKSWSSLLPRKIKDDERREYWFEKTLLHLGITMTKQSLLKHVLTEGDKMLISVLSTDRDKGVYGFTVNYGSLVARILFQPLEETGRTFFSKMLADKQDTSARQTAYHVLMTFLQFHILLGLLFFCFATNYTRTLVDLLAGSTWSIQSDAPKVLAIYCMYVPFMGVNGITEAFVQAIANKQDLNRLSYFMVFFSACFLISGIVFMHWLPLGAIGLVLANMVNLSVRIVYSWFFICRYFEKPKSIWSWFPHPMTTLSFVTAWFITHWSENYVGWYTLRQKAAHIGVGIICFGLVVIITLWKERAFISNIKQLSKSKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IS68</accession>
    <name>A0A367IS68_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003875">
        <property type="protein sequence ID" value="RCH80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IS68"/>
    <dbReference type="STRING" id="86630.A0A367IS68"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="462"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62786" checksum="BA230F2E645BDDF2" modified="2018-11-07" version="1">MTVGASNGKELRVYKGNQPNMDPNGEIALFDFLFKQDGRLPLDHKIYIDSNDPTRYLTYGGLAEKSLQCAAAYKHRFGLQRGDVIAICSPNDIRCPIFFFGAIAAGCIITLLDHSATSTPKNILDELTTAKPKLFIMHQSQKDFAFDAAKKVGLTEENILLLQDNEAPQDNTHSHLLTADDTLLSHDATTKPYAYNKDDLLNTPFCLYFTSGSTGNRKACMIKQNSLVCLLRYLSKNLPIGCLSTVATSSFCFGSSLVIHFMFAVYFGISVYIYRGGKNALEDVCSITDKYKINMLMLSPHLATVFVKKSEIRRKYDLSSLKKIFVGGSHTDMTLLRISKQEFGFPYTNVFGMTECVGVFEQTEEWALIGSVGKLSYGMSARIVDQDGNDVLLGEPGELRLKGPMTTIGYYNNEKETAKLFDEHGYLRTGDMFRMDQDGLFYYITRYKDLIKYHRFHIYPIEIEEVLYKHPSVMECAVVGVYSEQEAAELPRAYVILAEQEQNKENVLQDILDYVHSQVHDSRKLRGGIYQLASFPRTASGKIKRRELVAMANQENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISC0</accession>
    <name>A0A367ISC0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Restriction of telomere capping protein 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003852">
        <property type="protein sequence ID" value="RCH80552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISC0"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="177" mass="20181" checksum="21813EF14DF0599B" modified="2018-11-07" version="1">MLAQVYRHDYREIQKLVTFTSREIVIIESEDFQGMINSRHGKFKGTAQRVFDDLEEMGYQTIFAQMVFASSCAGLYIPGYYGDDGAEAIFNVGVRKLDMKKLAKTPWAENASTMANHVNLLRYTMVPNIALHLIQEDISAISEGDDCSFDYVILERILTITAHSNYKLIHVELDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUQ3</accession>
    <name>A0A367IUQ3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_003519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003443">
        <property type="protein sequence ID" value="RCH81423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUQ3"/>
    <dbReference type="STRING" id="86630.A0A367IUQ3"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH81423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="46196" checksum="51C291CA14759B00" modified="2018-11-07" version="1">MPRKPEIEYISLSTCRKGEGRNAPVHLKKSFEFLQKLANNALKAGPFSIVTDKQFPHVAPSGDVHDFLSYAPYWWPENTGDKNTKYVRKDGKRNPGLLKNKTRVKKPTKHYKDIQIVKDQQQLELFAENFMYLCLGYFFFEMESYAVYAVELLQIFFLNETTRMNPNLNYAQLVRGSQNCTKMGRGEGVVSGRALCRIANMLSYLDNFYLYRPIDQHIKAWFNQYFQWLIGSPVAKQAARAKNNIHTWYIAHVVSTVRFLDPSSAELTRHIVDFFEKTLPEQIDMATGDQPLESKRAQPLHYLAFNMYAILYIAELAKSIELDMYLTKKEILHTAALYMIKVSKAKQKIDITEAARCVEIIWKRVCGDDCCKEFIDLCHNCEFAERISGPKNAVCKCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWB6</accession>
    <name>A0A367IWB6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL28_2</name>
        <name evidence="6" type="ORF">CU097_003587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003225">
        <property type="protein sequence ID" value="RCH81916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWB6"/>
    <dbReference type="STRING" id="86630.A0A367IWB6"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="139" mass="15274" checksum="1F7427D21C7A5FA6" modified="2018-11-07" version="1">MSSELVWAIVKNNNSFLVKRDNAQFSAEPTNLMNLNSFKYSGIANYKNVAIQPAARGVRVTLHKAKKEQLPAKSTNTVVIAKTRRQTAKSVANLIARATKYRPDLRAAALARASAIISSQKPVKVQKKREAKGVRANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWF2</accession>
    <name>A0A367IWF2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinetochore-associated Ndc80 complex subunit nuf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NUF2</name>
        <name evidence="11" type="ORF">CU097_001254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003186">
        <property type="protein sequence ID" value="RCH82007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWF2"/>
    <dbReference type="STRING" id="86630.A0A367IWF2"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="333"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH82007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="418" mass="49062" checksum="D262FA2291DB1A85" modified="2018-11-07" version="1">MSQTSRRTSQEVYISPSKPPILTVSQIIETLVPCGLQISEEFLNNPQPDKVQALYWVFIDILVGWRIRHIEERINALSKKLTEDSARSIELYKAMKKLLQSIGYTDFTMLDVVTPTKPRLVSVLSVLVHYMAFRHKAWNIVNKPLKQSMQKMQNAVVVCQEEAMIKERFIEAKAIRNQHASEIKEIEKDNQALLEELQQVEKKSKELNVEHQMIKSEQAPMIERLHSYKETLGLSRERLVEYKSKAEINIDHLMDSTRTFKLKTEQSREMILDYDSKLQRVETAFPRHKAILKALSTTLKLLRDVYGENAELNKAKSTNTALLEEIFNRKVQLESEEKSSEAVMKEMRKYEHNLNKVNIKFENSRERHKTRQKEFEESRKDLEEKLHGAYEELNQLMREITTHEEEVGEIYIYHLDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWW2</accession>
    <name>A0A367IWW2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003152">
        <property type="protein sequence ID" value="RCH82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWW2"/>
    <dbReference type="STRING" id="86630.A0A367IWW2"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="19537" checksum="9A4DD939E62DEAE1" modified="2018-11-07" version="1">MQKLVARVGTFKQPYSRLFYTSSVLFKSEPIRYDDLGQRSIEDYPELIIGWSSSTDTLNTRTFVENGKFVDFLTKTLKENIHKVNDTNLKAMADWQKEGWMHIGDERDPPAWGRINFPEDIVGSVQLVNGIIQEGTYQPMPAHRLISGKGIFQLSEPLTRCVISAAKAKVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWX4</accession>
    <name>A0A367IWX4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003113">
        <property type="protein sequence ID" value="RCH82184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWX4"/>
    <dbReference type="STRING" id="86630.A0A367IWX4"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52487" checksum="47CEC52505C840B8" modified="2018-11-07" version="1">MTALPSSNSHSNDSNQSSPYTSEISLTTNTSSSSGPPIPPPHLENVQFYTPAPTIKQNQMANKDFDYLPSSSIDMATEASKRRSERIDSVNQEFPPVSVENIRKLRDESEQSKDPSRRLFFARYLLQAASHLAPNPEYPERTEQLKNNLQGEAVKIIKKLASYKTGYAEAQLFLGNCYGNGDHGLKPDVDKAFALYLQGSKQNHPECTYRVAVCYEHGLGTKRNYRHAMQFYKKAANLSDPSGMYKLGLILLDGLVGQQKNPREAISWFLRAAQIADENHPEALHQLGLIHEKESDIPSVIPDVDYARELFSQAAVLGYAPSQYKLGWAYENACLNCPTDPRRSIAWYSCAAEQNDGEAELALSGWCFTGADGILPQNDTEAYLWAKKAAEKELPKAEYAMGYYTEMGIGVSKDLDKAKRWYTKAASHGDEKAIQRLKVLEQSESTPLKRRPTRNKNGKPTAKSLDCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZ91</accession>
    <name>A0A367IZ91_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM32A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_002494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002811">
        <property type="protein sequence ID" value="RCH83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZ91"/>
    <dbReference type="STRING" id="86630.A0A367IZ91"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12137" checksum="C81EDDB37B68CD9F" modified="2018-11-07" version="1">MSAYDEVKKGSLKFKGGGSCSVKKKKKKSKSDKEKIERALRESSAEVFQEVEKTEAELKFEEIQRKRQMERVSKAATKSHKDRVSEFNQKLEKLSEHHDIPKVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZK5</accession>
    <name>A0A367IZK5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002765">
        <property type="protein sequence ID" value="RCH83128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZK5"/>
    <dbReference type="STRING" id="86630.A0A367IZK5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="349" mass="39937" checksum="3BF14E6D968341FE" modified="2018-11-07" version="1">MNIKYSANRSKELVQVCRLMFATTKEVTLRGYRILERLYQQAFWDKAIITTFQEDMGSSRTAVNHNVIGTEREFHNEETSTYWLPKDDEEQKRLAGQHFAFKDLYEGNVLPSVTKALDFQKGITILDVGCGSGVWVMDMITEYPNCTYHGCDIVDTTNKKLPLKQFTYAYGNVTKRLPYEDNTFDFVHMRFFVLALNEEHEWPAAISEVIRVTKPGGMIQVADCDLRLPKDHTAVFHKVMHAIRTVCISRGQNPNIGVELEKMLSKHDNVKIVQSDYRACDMSSGTSAAKKFIWDCLEGVKSIQPMVGPMLGIKTQEDMANFLTEYKHSLETQQCHFCFNSVAAQKLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0T5</accession>
    <name>A0A367J0T5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_007545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002626">
        <property type="protein sequence ID" value="RCH83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0T5"/>
    <dbReference type="STRING" id="86630.A0A367J0T5"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH83547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="30402" checksum="E97B37082F9E3F3A" modified="2018-11-07" version="1" fragment="single">MSQQQQQQQQQSLTNTNTINSTNTTTNNTDYQTNFNMSCPVTKLDLPDQSVAYTGATFYVSPLATTTTAAQTTPSYFYDSASVQQPFTPANNRVTISPSSIMIQEPPMLVASSSSTTTASTMSSSSVEFLNEAFAKATSLPESFYPEFLQYSKETYEQSTGGGPHRKKQKSHHSTKGKKEDDHSDEDVNPNGLSSSELRRQIHIQSEQKRRAQIKDGFEELRNELPACLNKKMSKVALLHRTVQHIQHLKDTQMSILSELERLVHENEQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1D5</accession>
    <name>A0A367J1D5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002568">
        <property type="protein sequence ID" value="RCH83747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1D5"/>
    <dbReference type="STRING" id="86630.A0A367J1D5"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="5">
        <location>
            <begin position="462"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH83747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="692" mass="79358" checksum="D80498A0651D5BFB" modified="2018-11-07" version="1" fragment="single">AKKTISLSFDQEEEGGEGVEEFQVKKTNKGYKLQIREDLNPLADLTDTTTHTTTTSYDIATLNELRAATPSLSAKSTMSSEDALLHEKFPSTANPTTEISGIPDASAILAAKKKREQMRKGFTIRDQDDGFIALDSKDETELSSGRLIREEDDIGDDGEAEFDKYVGGSFTINQGKAKAMEKERRDDLREMIDEAEQDEEQSEDIGRWEEDMIKFGGAKTQRKSNDPFAAPLNYRPAQVPESAALPTLADVMSSLNLAANDMAFSMEQHKNNLAEAQKSMDSLKTTERDIEREIERGSGRYTYFQELSQFANDLGEFLDAKFPELEDLEEKAHSMFASDAEVIISRQWQNTIDDLSLFAQVQYTGNETEEDGDLDEFGRMKDLKNSDTARRRRREERIQRIARQADLAELSGEEATREQGLWTDDELQEEHIIQRDDKLQDIEMAQVNNMMNDVNNEFKSLAAVKSKFEAWKTMYYDDYQKAYGSLSLPTAFEFYVRLELVTWNPFCDSLEFDSMEWHRTLSEYGLSSEHEDPDTEMLNKIVEKVIIKKVKSYLETLNARSSRQMRHASQVMEQVSYYVDPNEKAYKDLAIELVHTLEKQISRIADVVETSTLKSNLDQEAIEAKHRFFWSQCKYLKTLAFLRRQISRDQLDRLVNIVSTRLITPILQPQLDPLDAQLHNEMLSLLSVLQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1H2</accession>
    <name>A0A367J1H2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein rad50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RAD50_1</name>
        <name evidence="9" type="ORF">CU097_001855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002622">
        <property type="protein sequence ID" value="RCH83561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1H2"/>
    <dbReference type="STRING" id="86630.A0A367J1H2"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="8">
        <location>
            <begin position="207"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="282"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="415"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="542"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH83561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="835" mass="96944" checksum="AAECF8FBACBED485" modified="2018-11-07" version="1" fragment="single">KTAALTKQNMLSDELQLLRSRHLSIIESKKRLTKLIEDDKAQIQAHKNRLLEFEVSTSEIEDAKARVEREQKKLKELEATIDHSVKEKLQNKENELKELDNRASELNDEMNRLSKQSDSSAKLYEECIESVQSIIGKKPTKKDLERELLTFKREREKNIHDLKALRNQANNEASAADGKIGVARHHISVRKREIEKHQATIRAACGDTEFMEALAQNEKAIEDIKEQLANIRGAELIYGKFFERAQNSKCCPLCTRSFNEDVENDAFQGKLQTIMQRIPEQRERLNNKLKTNEDKRIRLRAAQGSYIKLETLNKDIANLEKNLGEFEKEKENASNRADVASAELIEIENYTSKIDNMLKTAEEITRLLKECNALQRDISELENELNFMGSTRTMADCQKDMEEISMKSQAVRRDIKRLHDDIDLSRRQIQAVENNIRDFRENLLNCQHKLDFKVGVEMQLKEYEENLKEHIEELKKIEKDIFPLEAQVEETAAAHENAMGEWRIAEENIVAEQNIFMRYIERLDELNRRISRDEATSGSAKLESAMEQCTELQKLIDRLKSQITETTDRINALEKDESERRGIERDLQDQIKYREMQAELATCENELRELEEKQGSTDVSALTEQLQKAQDEETNLIDKRGSIRGELVQMRDQIRRYETELSNDYADVDGRYGQLFLDVKTKELAVSDLDKYNIDYIEIRADNEGSAANRTFNYRVVMFQNGSELNMRGRCSAGQKVLASIIIRLALAETFCINCGIFTLDEPTTNLDRENIESLAESLARLISRKRTQRNFQFVIITHDEEFVEYLSRYDITGQQYRIKKDAYQHSTIIAESNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2V4</accession>
    <name>A0A367J2V4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01002418">
        <property type="protein sequence ID" value="RCH84250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2V4"/>
    <dbReference type="STRING" id="86630.A0A367J2V4"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH84250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="77" mass="8535" checksum="B90CE0709D758565" modified="2018-11-07" version="1" fragment="single">MVFLSNAVSDARIEEVNSKGELHHDSVGTTVYGTRWASEDIPRFDLPQDEMPSNVAYRLIKDDLALDGNPALNLATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3R0</accession>
    <name>A0A367J3R0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002331">
        <property type="protein sequence ID" value="RCH84568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3R0"/>
    <dbReference type="OrthoDB" id="2290890at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="326" mass="36790" checksum="8F51ACFABA787E13" modified="2018-11-07" version="1">MEERCPNQHKDQKQTYESPVTSSSGSSPMNNMIHPFNLPAGHWRHPYSSEPFQLYDQHDLYTKAYNSYPQSYLHGESFYSGYHTASHSPWAEAAEPSSSTSYFDRNVSSYSSAEIYSSTQIQRVSSIYPDIVSGVNNENRSQPTHQGTSKQQGPSDTKNNSAQGHKMPEVEQLQEEISFLNDEITTILIVLDSLRNAFLTDNASTATPSLNNRPMLKTLNFTKNDRISLNQTTYITGIDSNIKGNALDIVDNPEVEKEIRIAYDDIVMQVKQLERKIDTLEQKSRIIMAENRKRSLGTSQADASILHHQLHGNIHQAHMPTLCTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3Y0</accession>
    <name>A0A367J3Y0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MPK1_1</name>
        <name evidence="11" type="ORF">CU097_003618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="PJQL01002301">
        <property type="protein sequence ID" value="RCH84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3Y0"/>
    <dbReference type="STRING" id="86630.A0A367J3Y0"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="410" mass="46892" checksum="63D1E7E3281851E6" modified="2018-11-07" version="1">MKYHNLPCYGQSFEVYEKYAFEREIGKGAYGIVCAAVNTKTGVSCAIKKINKLFERPILTKRALREVKLLEHFNGHKNIIGLYDIDIVDYNNFNEIYLYQELMEADLHQIIQSRQPLTDEHFQSFIYQACCGLKYIHSANVLHRDLKPSNLLVNTRCELKICDFGLARGYIDPSSGQTDAGFMTEYVATRWYRAPEIMLGFKSYTKAIDMWSVGCVFAELLGGKPLFKGRHFVDQLNQILYVLGTPDDATLCRVGSERAQIYIKSLEKFQKIPLSQLYPNASPTALDLLEKLLTFDPSSRITVEEALEHPYFELFHDPNDEPSHSTLFDFSFESLDTIEDMKETIIEEVKHFKARKHSLKIDMKGLRRQHSITTPTKANGPDCTFGYANELIASPVEVDPHLERDLSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3Y1</accession>
    <name>A0A367J3Y1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002310">
        <property type="protein sequence ID" value="RCH84637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3Y1"/>
    <dbReference type="STRING" id="86630.A0A367J3Y1"/>
    <dbReference type="OrthoDB" id="2300048at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="368" mass="42160" checksum="F30B3E5F556E1CD3" modified="2018-11-07" version="1">MKKVDQELTEEINSNVSSICSDKNLQLEEDKRRIKSVPILKTIFLDGEELHERYTPKDTLSPLERKKMTIGLSGIVNLIAEDREEQSSLFTEEEWDKIKAKYAKYKLKISTISSNLKEKWSYIAANCLNDGGLRGARKYLDRLCAMKEVNDVDYNTYKLLVTVSDTQQNQQHILNPKCPEKLVEGYFTYLICLALFQKLSSVNGNVIQLKPADSISDNSTKEKERVYGGDHSNLKGFKVDIRFIYTFNDQEFDLCNFECCLSNFPKEKVQHDRGELIREGRISTANLFNAINSADSAQTWIIQVSGLLYNSHTIEAKLKRARTKNQNKNIRRNHVRTPSQSPPRHLVSPATVGWFTPPRGQVTYSIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4A1</accession>
    <name>A0A367J4A1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EAF1</name>
        <name evidence="12" type="ORF">CU097_000081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002265">
        <property type="protein sequence ID" value="RCH84794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4A1"/>
    <dbReference type="STRING" id="86630.A0A367J4A1"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="558"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="733"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH84794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="761" mass="86521" checksum="F87C165E679B32FE" modified="2018-11-07" version="1" fragment="single">MDTTDTQKTIQRLRNNAEEERKKKIRTIISHREMLLKELFTMTGEHTDESEGFMAFLKGADVTQIDQDKWNAYLDKYKLSNIKLFKEELIPSPSEQPQQPLSPSVSPSRRVVSPPARMVTRGVSGAVRPKSVDEILSSLDQKDLMLSSPTKEKPSSPSSRHSQPTTPSTDRLLPSTSTVDQQPSSPAIPISSTIDPKTASSLVYNGIKLADANTSSKTSSIDLYAWQLKATHFPLYKQLQTARKTLTTHDWMLARDELKAVKTIQRIEALKKKNGWSLRQLKRHKAPPRAKTHWDSVLDEMKWMQTDFKEERKWKIAVAYMLSKAVMEWHWTDDKSTVCIKTRIPEPKAPVDDIPSLTDMDVDQQRPELVPDEAMTSDEPLKSDTMMGTDDMKQSEPMDMADDAMPTTPPLASHVIQEYRFILKEMDPDIPVITLSFETSVNFNPDALFPDLLLYEPPNPEFNDVYFNEIEFNRVTPISKWMTKPIALKSHRQMTRKRRANGEEIFFAEEEKPEVERLPRFERYDTTPLISPLFAAPTKKQKDSTGVSPSQPQPPSNREYLPSPQWTEEDDVCLITCILQYSFNWDLVADAFNSVRLPVTGERKTAFDCYERWKRQGLTSSQGHVNAAYASRIKKELNPTQAQPPTIVRFDSPQKRQRQHNLFEAIKKTQRKREELVKNAASTTAPPPRPTIETHGLSSTGQRLPSAMEMSLHKAQRERQMAQAVLEQRQLSAAITLGSQTPNGAPRPSPVAAPQARPTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4A2</accession>
    <name>A0A367J4A2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_002524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002338">
        <property type="protein sequence ID" value="RCH84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4A2"/>
    <dbReference type="STRING" id="86630.A0A367J4A2"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.900:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="253" mass="29073" checksum="F6C174BB18C2F673" modified="2018-11-07" version="1">MVIQQPSSQIKLTNVSVVRLRKGGKRFELACYKNKVMEWRSNVETDLDEVLQIHNVFTNVSKGQLASKEDLKKCFKTEEVDKVIQEILKKGELQVAEKERSNQLETLWKDIANIVTDNCVNPQTKRPYTVTMIEKAMQDLHLSVNPKRSAKSQALDVIKQLQEKQILPIQRAQMRIRITLQQSKESKKLRESILPLLTSVEDEDAGSSEIELVALVDPGKYRTINDLLQNESKGKGQLEIMNLREKEEGDERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5C5</accession>
    <name>A0A367J5C5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002173">
        <property type="protein sequence ID" value="RCH85142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5C5"/>
    <dbReference type="OrthoDB" id="2212653at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016736033" evidence="1">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="171" mass="19109" checksum="96C29A46A44C420A" modified="2018-11-07" version="1">MRFITLAAVVALLSNPVLSAMTDPNDPRIEQWNRMKIAMPDGISPEENLIARVDEDQGSPLTRPMHRHQLNQGQGYKQMAMSQNFKHVVPLPPRAAQVVSSRVSKQAASPTSRPFRKLIALDDKGNRQTLSTEENSVRDLLKKGLIQEKQVVGMDSEGNVEILDIPAYNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5R9</accession>
    <name>A0A367J5R9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002138">
        <property type="protein sequence ID" value="RCH85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5R9"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="594" mass="66594" checksum="298AD6B6B154CA43" modified="2018-11-07" version="1">MTETFYGYIETTQDVLLIFEGCRRGLLPRICRRLQEKERRMIRSGSVFVFDERESGIKRWTDGLVWSPSRILGNFLIYRELDKRIPGDKKLTSITNESRQRSFSADQTAGILGVSTDRNRERRLVGSLLDSYRFRKDGLIKKTMSIIVNGVTQHLVSYYHPQDIISNKLRTPSSVPELASLEISPDLLVKQNFRVPPMVEPSFDHSENAFINSSSYDERRAHSFRSMSLGSLHNTNSNSSNNMLGTPGNPSTPSLLYTPSLATNVAAGRMSVNSSNNKLPNNALPSSYYTNPLYSNTAGFSPLPSPSSITSSPMLSPVHQSFPHPRHYSISSASSGSIQRFAARNSFDLMSGIQTDRQQQPSPSQQQQQQQHHPHPTSQQQQQQQQQQQQQQQQPSSSQQQSIHPHMLPDMFLSGDTHIKTENDTSVNTGSEAVGISTPVTGASGFSSSPNIGQLLNPIHPLNTTIKQNDPSMTNAQLFQSMNISSPSKYQDFSLPSTTTATPSGTPHFDSFSNNNNNHYYEQQQQQQQQQQQQQQTVTDSDHHYHHHQEQQDTHSTNNLVPLFRNGMVLPNTNSSSMYDENASDLGIEPLMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6M8</accession>
    <name>A0A367J6M8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MAP kinase kinase (MEK)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STE7_4</name>
        <name evidence="11" type="ORF">CU097_004966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002085">
        <property type="protein sequence ID" value="RCH85489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6M8"/>
    <dbReference type="STRING" id="86630.A0A367J6M8"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH85489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="428" mass="47900" checksum="CC9C492F36454422" modified="2018-11-07" version="1">MLKPIVRKKRNYKNLALPASSAATAAPVPALKSAKQEEYDKLYKDLSDLEIGLELRLDLREEDIQNIEELGAGNGGTVYKVLHIPSKRIMAKKTIYPQSLLDSPAFARRSGIFGSSPKENDNQEDDGEIEDVVKDLSIHEIKKRPEKSMSYQIPTSTNKQPSTNSTDYSIANMRPLLPVHTKRKKPEDPRVTVRKQVMREMQFLHDCNSEHIVSFYGAFLSGGDISMCMEYMDVGSLDKIYKKSGPIPMDILRHIGYAIVDGLIYLYDSHRIIHRDLKPSNVLVNSAGQIKICDFGVSGQLIDSVANTFVGTSSYMSPERILGSPYSVKSDVWSIGITLMELGLGKFPFTSSDGRSLAIFELLQYIVNEPVPTLPAGKYPQDYEQFLSLCLVKDVQTRATPNDLLNTAFIKNTTATKEDIMNWAKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7L8</accession>
    <name>A0A367J7L8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ca(2+)-dependent cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCA1_1</name>
        <name evidence="6" type="ORF">CU097_002942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001986">
        <property type="protein sequence ID" value="RCH85906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7L8"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="124"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="422" mass="47564" checksum="8A398F6C6DDA5970" modified="2018-11-07" version="1">MDRYGYPEPEEVTSSYEHHYSSHTYSYTSSENRHSSSSHRISSDDSNDPTFTEQDYAYPNPNYPQPPESKHNPGPEPVPYGGMVSHQDDNDDDDREDGKFYLHVDPTVDQDKLSDFELSNCQGKKRALLIGINYVGTKNELNGCINDVQNIKNFLTSLYGFQEEDMVILTDNQEDPKLKPTRANILAAMQWLVHDAEPNDSFFFHYSGHGGRIEDSHTDEDDGFDETIYPLDFEQFEGTSGQIRDDDMHDIMVRPLPKGCRLTAIFDSCHSGTVLDLPYVYSTRGEIKQTNLFKHAGMGLLSAGVLYAKGDKDGALSSIMSLGKQLLEARMISSEARKRNTTLADVIMFSGCKDDQTSADAQEAGRATGAMSYALTTTLRQNPNQSYHQLLNNLRRILRDKYSQRPQMSSSHPIDVNLEFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7N1</accession>
    <name>A0A367J7N1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_005433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002003">
        <property type="protein sequence ID" value="RCH85839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7N1"/>
    <dbReference type="STRING" id="86630.A0A367J7N1"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="162"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH85839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="906" mass="103317" checksum="15AD5327F4551A6B" modified="2018-11-07" version="1">MDQSSTQGILIHLNQGNYQAALDLATELSLDKTAIYKAQWSQLSRQKGTHIQESDLELLTLVKDDDAWVAVQCLNTVVDEPNVQKKIIKLGKECAMKQTEAIIAKLDPQYTPTTQELTWLRTRHYFLQYSDRLETIIKIWPSLTDKGSFAEAYSQFRDCNLIALAIESAREENNIMLDALFMHHGKQLLPYRLFILSQIPETADPSSFDLPHVTNDHEDPWLQEPWRSELDVVEQDWVQDLIRLDVPEKAAYLKTLHDSIQSTDYPTSLKVIADWYMERADAADAIGLSTHALEISRYAQVMGVTGIESKLAEYEWLCKYVYSSNDNRFINLSKFRELSNYEVLEGLLHNTSSKTIIDDMLRLALPWIEVCKSRKIQEYEDEEKAEFLLHRWLLGTQATPDHLDRCCLICEHSKPTLSTEDRVIKDNFDLSRLVLSIIYSSDGSHMEYLVRLFECLPIFSDTPQQDKEVTDMATILPYASTPLGIFTALQEAGPFGLTKMMDTLQGHLSSAEMLARYHTYVPLRWYLEDQPVSSQRQLCIRIASQAAGGVESGGARFDQDDDWRELLDDMLRLQDGGKGVFGKLDSEEVLEVFFSSLLRCGRFKLAKELILGRNKLIDITKAEKLVIDAEREFFDNATSGDMYSGDLKQAWDCLKILPPTTQIKKEMGLIEAAHTLIAEYRVQHQPGISLMPIQIRQSSNRLEFISKLLNIKRDIYNHHEKVLQLVTRLGYNEDDTLAKVKAISMLASAALVEEDYLQSYKLCQIAVEMALNKSTKHPKAYNDQVDHTVWQICFNLGKLKSFDDVSRRLNVLSMAMSLSPAEHLRDVLAAWRELDATKPSQIDLAQLDADRYETNTESASNWQGLLQNATKQWSLGDLLAGTSGEQTEGGKRKRDIVRNVVGSWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8A8</accession>
    <name>A0A367J8A8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA wybutosine-synthesizing protein 3</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_007538</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001932">
        <property type="protein sequence ID" value="RCH86135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8A8"/>
    <dbReference type="STRING" id="86630.A0A367J8A8"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1960.10:FF:000003">
        <property type="entry name" value="tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="12">
        <location>
            <begin position="12"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH86135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="277" mass="32327" checksum="8FE0B6D425592ABA" modified="2018-11-07" version="1">MTTHHNTDFLSRKEQVIASLVEHLDPERRDKSPKGFIDAPILDLMHVINKHPDYYTTSSCSGRVAIYCPALENDKVATKGGTWLYVSHDPIPVPEKEKDSWILQLLFGNRNVVFDYERPADLVHKQLIYFKFEPLILHIEASSYESAMHLLNIANQAGYQNSGITVSRRHMLAIRSTLKIDAPIAYIENDTVYCLVDIAYLMLLVNMSNEKFQQNIERMSIFEEKMRRELENNQSQVKEETKEERRERKRREGLQKKNQVVKEKVEQQDLEDMDGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8W6</accession>
    <name>A0A367J8W6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_001825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001879">
        <property type="protein sequence ID" value="RCH86383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8W6"/>
    <dbReference type="STRING" id="86630.A0A367J8W6"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH86383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41434" checksum="E26EE65100ADE607" modified="2018-11-07" version="1">MGNFKSSLKGDKQNGLSISRSIDRQIKADQKRMKREVKLLLLGAGESGKSTVIKQMRLIHASGFKASEREGFRVIVFLNVFTTMQTLLEALEILNLPLDDPVLREYTKLFKQTPSLEENQPFPEIYLQPLKSLWKNESIQTAYQKGNMFALHDNISYFYDQIDNLWSPGYKPSDQDIIRCRAKTTGIVETTFHLGNLTYRMFDVGGQRSERKKWIHCFDNVTAILFVVAISGYDQCLAEDRASNQMHEALMLFDTTCNSHWFIKTSMILLLNKIDIFKKKINYSPIEHYFPDYQGHVHNLDTAKNYFKQRFQRLNRNPDKRIYVHFTDATDTHLLQNVMVAVSDIIINENLNSIMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAZ2</accession>
    <name>A0A367JAZ2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GNPNAT1_1</name>
        <name evidence="10" type="ORF">CU097_006790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01001731">
        <property type="protein sequence ID" value="RCH87090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAZ2"/>
    <dbReference type="STRING" id="86630.A0A367JAZ2"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="20149" checksum="A600D376D05AFBFB" modified="2018-11-07" version="1">MSEVTLFDSKYLSPEVQAALPKGHTLRALRSNDYERGFLKVLEVLTEVGNHTKEEFTEQFNYLKKHNHEYFTITITDDAQDKVVAVGTIFIERKFIRKNGLVGHIEDIAVDKNQQGKKLGLRIIQALKYIGAKNGCYKVILDCSEKNVPFYEKCGFNRKEVEMAWYVPSTEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JB63</accession>
    <name>A0A367JB63_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001714">
        <property type="protein sequence ID" value="RCH87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JB63"/>
    <dbReference type="OrthoDB" id="2289567at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016868518" evidence="2">
        <location>
            <begin position="25"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="680" mass="76417" checksum="06268C162832DF0C" modified="2018-11-07" version="1">MKSNKASITFAVTLVLGTCQLALATPLFNIPSANHLNDASIEDICQDFRITYPAKEGVVFDDNSKHIVAWQAADSIKQVNLTLVSNQNPSSTAYIGTYDATLGATDEVLFSLQGRQDGDYHVHIAGQGDNSQFCEADSATFKINALPANATVIPSTNSTVTNAPTSSGDTQPTSTSSTDSTGTTTIDLSATTTTPAATTSAPSDTSSSTAANSSIDQTQLDNLLEQIHKSTASSNPSHEDDTNWTSALDEVSDLTKGDKPHSNDPAIDDILEQIHSNRIHNNAVNTEQESSDPSFRQYIDSLDQDYKKYIHKNKETETEAVTHKNDADPYFTNEDLSTHENAADYKQWHSNDANPYFTNTDLRTNHNNGEWEEEEEENHVNYKQWHSDDANPYFTNTDLRTNHNNGEWEEVNDEHDNEATPSNGWSSTDPYQEPPSHDNLAEWEEEGNEHTNEWQSDDPIVHSPSHDNYAEWVEEDNTHNNSWESTDPYVEPSSHDNDAEWIEENDGHTNGWQSEDAYVESSSHDNDAEWVEEDNNHNNGWESEDLHVEPSHDDYAEWQSEEDTHNNHVDGWETEEADVEASHDNDAEWQDASDDVHNNGWESEDLHVEPSHDDYAEWQSEEDTHSNHVDGWETEEADVEASHDNDAEWQDASDDIHNNGWESEDSHVEPVHDNYAEWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBC7</accession>
    <name>A0A367JBC7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001699">
        <property type="protein sequence ID" value="RCH87237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBC7"/>
    <dbReference type="STRING" id="86630.A0A367JBC7"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="134" mass="15302" checksum="CCC8DFEC3D0A6D28" modified="2018-11-07" version="1" fragment="single">MQPLVPIETSKSSETLGQGDWLALERIEFIDKQGTKRNWERCIRRKSHSNKVDAVDIHAIILTPEPELLLVIQYRPAIKRYCLEFPSGLIDANDDDPLISAQRELKEETGYVVPKEEMRLAKLPLAYEPGLTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE15</accession>
    <name>A0A367JE15_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SHE9_2</name>
        <name evidence="12" type="ORF">CU097_003356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001518">
        <property type="protein sequence ID" value="RCH88166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE15"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="42817" checksum="B745EACB3840A292" modified="2018-11-07" version="1">MSFRAIASKRILVTQRCLCRQSSSFTGSKNSLEKIQTDLKSQLDQYINKLHKASDKFKQLTSEVNNSKEALQKASRVLNELTGYNHIETVKEKVTRQAALFESTRDEVQVAKREYEQAIETRSSTQRSINELLQRKHLWTADDVTKFTELYRLEHAHTQAEMTAKERYQTCEKQMDREYMELARSIMERYHEEQLWSDKIRSASTYGTWALMGVNLLLFVAVQTVFEPKKRKRLTDRFEELLVAKVNEEEEKFKHVFESLDEKDRLLVQQQIALMEAVNGLTEHPLFDQATLDALKQTNNSANNPIESSETNKVTPHQTPLLDDDNLIKAILLPIENQVEDKDHSYLWQSVQSAIAGGLVTAIAIYFLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE65</accession>
    <name>A0A367JE65_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_011183</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01001509">
        <property type="protein sequence ID" value="RCH88216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE65"/>
    <dbReference type="STRING" id="86630.A0A367JE65"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH88216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="246" mass="28797" checksum="2CCE88AF7234797A" modified="2018-11-07" version="1" fragment="single">RYTWGGMGDSFYEYLIKQLVVVKGKDQTKFKLVKEIIDGLEAQLLVDSAVDPNLSFLVEINDGQPSYRMDELACFAPAALILAARHFPDDFGHIESAANRLLNGCYSAWDSTMTGLAPEVFTWDMKPRFFYEHKPSVVPVVKSYILRPETLESLYYFYVYTKNPMYQDMAWDIFNSLYTYCKANSGYTGLYNVDDIEYPWDDREESFFFAETLKYLYLIFDDPHHPRFPFDQWVFNTEAHPLKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEF4</accession>
    <name>A0A367JEF4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001491">
        <property type="protein sequence ID" value="RCH88304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEF4"/>
    <dbReference type="STRING" id="86630.A0A367JEF4"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01682">
        <property type="entry name" value="moaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9741" checksum="615B59E8F1E04754" modified="2018-11-07" version="1">MKILYFAAVKDITGKEMEEVEIRKEDYTLQMLSEDLCMRYGEKLKTLLESCLFAVDMEYIQKEDELETLLTDVSEVAIIPPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEK6</accession>
    <name>A0A367JEK6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_006909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001483">
        <property type="protein sequence ID" value="RCH88350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEK6"/>
    <dbReference type="STRING" id="86630.A0A367JEK6"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="684"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH88350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="850" mass="96352" checksum="65E35B37EBD71786" modified="2018-11-07" version="1">MSNNKDKRRLTGYSGNTIGHQSVYDDYHDDTFEEYDEDSDSHEEEEEEEEEEHEVAHEDDTGSELSIPDADIDFDLVYALHTFSASVEGQATVVRGDALTLLDDSNSYWWLVKVLKTAEVGYIPAENIETPHERLARLNSHRNIEITRKDNFDAFPIPPSTNPTKTRKRVTLAKGVQYQSQIIFGSSDSEDDDFEAEFQEWDEKMRSSDESDLDSSTSGDDDEDDDPYHYYDEPQPIYPNQPHRSILSEEEDEKIIPNLDSHLSADSDIINDPRDFICYQGPQEMEQKKENDSDYDDNDGDFKDETIKISLTPSIARGSEDSRRDSDTSIQTKLKKAAKLERLLVSSSSPSSSTLPDKKEKKASGIRKFFSRSKKPGSNSSSNSNNNIDTAQVTINDTSSHNSSQPATVNETTRLKIQPGNPTMKFKESYIDVYPNTTACEVIQQILDKEKELEQESESSYNDYYLIVKTLSGDECTLIPSDKPLEIFYSLTAHLNTPMPSLKKARRISQMMGSDNHVGGPVRDETHDEVQFFLFSKTKRIEDGEIQIKVSLLPSDQMLEDSKRVDKLVKIPCSFLIKDVVTLLLEKFHILNGIVAGDDDKKSLRLTDENEIAKYQLAMSVIGQERLLPLNEKLLAVFGDDIPQIHYRRNSNPDRSSITVNITPPEKNETYFLLRCVERPKKKEIEKQTTGGPRHRPHHHLVRQDTPMPRKEPTPDNGFQPPTPTILSTSPKDELLTQIDEAIQDTLSHSSPSIISSSSITEKPTNTIPQRHIRPSSTESILFYTSDFGVNDLMVIIRGAAALHEVNPTSTTTTTLRSEISDVFKDTHSRLDQLEKELDRIMTEAVEVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEN8</accession>
    <name>A0A367JEN8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_007156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001484">
        <property type="protein sequence ID" value="RCH88345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JEN8"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="160"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH88345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1312" mass="148879" checksum="CB049BC8295EA272" modified="2018-11-07" version="1">MASYYHHKNQTQMSFSNNNNISRRVDSTVTSLSSSSSSSAHSRGSNKNNTRLLSTGDYDSLYRVPSSPTAESYYSSYPRREASLSSSSQYNNNSQYDSRSVHIDSLPPVPVASSSNRSRQRLEQCPEEEETQRYPIFPPTEEMLQKARSKMSEAESRPLKVIYAGDAIYKPDRGILSKTKRAHFVLTPKYLLVYKSAQKARGEIDFFENQAISTKSSKQNTIDKDRIFLCLSDIYAVHSVVTAVHTFRIDYLHPQSQQPFSHTLTADTSKECQQWIQALRAAVSVYHPSMSTVTTSERYAVIDRVSKHADVFSNTDDMNMFKVVFKEKRYKTAADAPREFFLPIILAFGKFSFYLLPVTVTDDEYRKAVERDRFGYLSIQSIRYDNVDDTVCIEVRQVNKKSRQLVFASTFCEDILRYFYRAINSIVPTNPLSLYQFLVPDHIKKAHIMPFRIAPDIDDEMTGHDDEEMQSFNIILRAYTAALNLNKSRFRYTITGPLRSKQFVLLPPNEINGSPSTYQKHELLALFKTIQANTFFQEVCFANHSLDILENWKVESNDGWTINIDHPLKDESVLCNELYSLLTSTKVLRKLDLTNCSIGRSLPEGTAKKSSAIATIGTIMQAGNTNLSRLSLGRNIISEVDFQSLIEGIKKHKKSIKELYLHECGLTKTMIEKVLWTLMEKNPEQVICLDISTETKNMMIDPEIVSKIVSHFRRLEILRMRGHDLIGLKYRFDLENSHLRELDISGSPMNTDTVSRLCRWMQTPAFNGIEALHLSGCGLNGRHVYELLCSISQSGNRQMHLNLSNNPIMKEVMHLPKLHSAILQGEGPCSISFAGIEWDDSTLREFIDCLRDNQTISHIILSDIKLKDTDKISEDTVRMLTSLFERNTCIKEIELNFKENKVTRSHYSQTCIKPLFTGALVQALYGLRHNYTLQYLDISGLGMEDAGAMALARVLRTNRTLQSIIIDDNNITIEGYRQLTKVIQDIATQVIDIPMPRNDLRFQLQYLTYRIEELLISINEAQFFLIHTVASDKKRAKTRELEILIQERKSCELALKNIEGVVQNLMITIQKNMRNYEEQHSRNMELQLQAQAAAQELAIAQVRIQSGRANSVNSFNLSAVGGRHGSSSSASSTTSSVRGGTVGRKNSTGGAYPRLGTYHPLTRASTILNSDYYPRSVSSPISPSFPTSTSIDSRMFSARNRDDDMFNKPHSYGSQPPVTPSTDQYYRQDYLDSSSGLISPPLGMSFGTRHVDDPGFISDFGYVDDFELGVEAAYSDVQKPSASVTDLDSIWDEDRVVDHFSRKLYLPPDARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEV0</accession>
    <name>A0A367JEV0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DPH1_2</name>
        <name evidence="17" type="ORF">CU097_005154</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001464">
        <property type="protein sequence ID" value="RCH88454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEV0"/>
    <dbReference type="STRING" id="86630.A0A367JEV0"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH88454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="731" mass="81565" checksum="B07AAFB84BA629D0" modified="2018-11-07" version="1">MSVEEKSTTVKPRKRFVGKAKRNQATNDAEAIEEGAVGFAKAPRARSNRVANQVPDEILQDPLLNKAIEQIPSNYNFEIHKTVWRVRKANAKRVALQLPEGLMMFACLISDILETFCNAETLIMGDVTYGACCIDDYTARALGCDFLVHYGHSCLVPVDITTIETLYVFVDIGIDTQHFIDTVKRNFEKGKRLCLVGTIQFAAALQASKTSLEQDFTVTIPQSKPLSPGEILGCTSPKLTDTDAIVCIGDGRFHLESILIHNPDLPAFQYNPYAKTFTRERYDHQEMHSLRKHAITTAKTAKKYGLILGTLGRQGKPQILEYLEQLIKDQGKDSVNVLLSEIFPGKLEQFDDVDAWIQIACPRLSIDWGYAFPKPLLTPYEASVALAWDHGHQIMDEGYKEEEGGNLLSLLSEFVDLILASIVVQAHRGDTTNIGTTFSTSVLNKIYLVEIKQSMTGRSIRYGVYNSCLYYKDMDQPHSCTSKTPAYSFDAGQFVAANGVDDANTMTTLSNYSNAVSNKNMTLFKCIVLIMPAVILSFVAFFCTLVIRKHRQNNLIPFIGSFASLLSFFTGAAGLAITIAAFWIGLADTEKQVQAISHQWGPAIYMVGVGIACNILTFICFLVGLFTHKNRQRDSTYDYTSATKANDTFVKHESYNNYGQAVSPPSPHYPSYHNQPDSNAAYQPYYQAKVDYQPQTPNAYDAYHSSYDNYSPTPQVYHQGGYSQKPQPYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEV6</accession>
    <name>A0A367JEV6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1_2</name>
        <name evidence="8" type="ORF">CU097_008293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01001460">
        <property type="protein sequence ID" value="RCH88478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEV6"/>
    <dbReference type="STRING" id="86630.A0A367JEV6"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="759" mass="87909" checksum="778ED3000679D667" modified="2018-11-07" version="1">MSKLPIIEVEHDVHAPASTYYTTGDNARHRTRTHTRSHQVGGTTTNTLEGTRRRRASHDEKNKSRRFLIDVEETQRKILEQEDTDGDFQITINDLGPKTMSLGTADSGGYRKIDIRGTYMLSNLLQELALAHDYGRKHIVLDEARLNENPVDRLSRMIRFNFWDGLTRRIDADSLEVICPDPKNRSTNRNPRIYVPCDDHEAYAFYKQMAEVRKHLHLEVEYLPREITAEYVKSINDRPGLLTLAMRKVKDENGNDTYVGEPFVVPGGRFNEMYGWDSYFSALGLLEDGRIDLVRSMVENFAYQIKHYGKILNANRSYYLARSQPPFLTDMAIKVYERLSPDKEQENKAWLRRILKSAIKEYWEVWMSEPRLDKKTMLSRYRPDGSGIPPETEASHFVHILEPYAKKHNITLDEFIEKYNAGTIKEPELDEYFLHDRAVRESGHDTTYRFDKVCANLATVDLNTLLYKYEMDIADVIRDYLDDDLEDFNGVKQNPDDWLERAKQRRERIDKYLWNEKESLYFDYDTVKEEQTTYESVTSFWALWAGCASHEQAQSMVKNSLSKFEVMGGLVSGTESSRGAISLERPNRQWDFPFGWAPHQMMAWVGLDKYGMLETARRLAYRWLYTITKGFVDFNGVVPEKFDVVSLSHKVEVEYGNVGIDFKCVPREGFGWMNASYQVGLSYLTTNMRRALGTCTLPDLLFEKAMIREHRMLGMTPEEEETVALRRRASTIAARAITRNGSINAAVTRISLSDAPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFN9</accession>
    <name>A0A367JFN9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPD3_1</name>
        <name evidence="12" type="ORF">CU097_000249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001415">
        <property type="protein sequence ID" value="RCH88740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFN9"/>
    <dbReference type="STRING" id="86630.A0A367JFN9"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH88740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="570" mass="64850" checksum="D41CB4CE5382D4B2" modified="2018-11-07" version="1">MCVANVGNYHYGPGHPMRPHRIRMCHGLVMNYGLYKKMEIYRAKPANKWEMTQFHTDDYIDFLSRVTPENMDQFQKEQAKFNVGDDSPVFEGLFEYCGLSAGGSMEGAARLNRGLCDIAINWAGGLHHAKKSEASGFCYVNDIVLGILELLRYYARVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEFFPGTGELKDVGVQKGKYYSVNVPLRDGIDDESYRTTFEPVIEKVMEWYRPAAVVLQCGGDSLSGDKLGCFNLSMKGHANCVRFVKKFNLPTLVLGGGGYTMRNVARAWAYETGVVVGQEIGPEMPYNDYYEYFGPDYKLDVRPSNMENLNTPDYLEKIKTQVFENLSRTLFAPSVQMQEVPRDMDMSEDEDEQDADDRYSQNFWDRRIVPDNEYYDSDEGEAQGTTENLKSRHERNYRDDSQVEKSGTTSPEAVNNVKISQEEEEELAEALREEEKEADIKTEQDINTEALLNSDTKPDTDVEMTDAFTNPVDDQPHIPKSATESEEEGEVKSTHSQSPRSRSPHIQSEMHMSVDDFSKENDVHPSPYEDALEDGEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFX1</accession>
    <name>A0A367JFX1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001407">
        <property type="protein sequence ID" value="RCH88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFX1"/>
    <dbReference type="STRING" id="86630.A0A367JFX1"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="223" mass="24479" checksum="1EA8D803CB6C93E5" modified="2018-11-07" version="1">MAFVQQQRRPVQRHQPYSDDSVLQQQSSAISDSDNDWHVISSTLSPSTTSSIGILSETESCCSSSFKPTFSDTDSEDIDHILEATLNIPSHDGTGTFGRTASTTSNSSTSENEDSAVMPPFLPTTSGIRSQELIEKGTYHEKKSSSPLYMSKNLDSIPIHHPAGTAAILSIVWNSLRRITNHIIENETNTMDTLSSLMSEAMLEGYLPFGSHLHMDKSLLEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFY2</accession>
    <name>A0A367JFY2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_006127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01001388">
        <property type="protein sequence ID" value="RCH88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFY2"/>
    <dbReference type="STRING" id="86630.A0A367JFY2"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="558" mass="64091" checksum="18A57C34A88B8070" modified="2018-11-07" version="1">MNSQQPFNHSHGSIVDNEPCYTILFVTCYSEGIDSIKNTLDSLADTTYSTEHKLLFIVVDGIITGEGNDKPTSDICLSLLTPLNDNHMHHDGKECEYEAVADGWKQKNKARVYMGYYRSLPTLVVIKSGTEHEKGQTKAGNRGKRDSQMILMSFFKKVLFYDRFTELEYEIFWKMSRLMKKGVTPDKFELVLMVDADTKVAPDCITYMVSAMKNDITVMGACGETKIANKSESWVTAIQVFEYFVSHHYAKAFESVFGGVTCLPGCFSMYRIKAPKQGRWVPILSSPEIIEQFNVSSVDTLHAKNLLLLGEDRFLSTLMLRTFPRRQMIFVPQAKSKTVVPNSFKVLLSQRRRWINSTIHNLMELVFVSELCGIACLSMQFVVVLDLLSSVVLPAATLLIFFFFMDLIFTHSAQYQTLVILLAAVGTPALLVIFTAKRMTYIGWMVVYIFAFPIWNFVMPIYSFWHFDDFSWGETRRVVGEKEENSNSDPMYVLYNEKAQKKHWHVWEAERLSQLKHRTHSMDAKGTTSKKQVNPYLPTVTRPQRKRVTSYSYHLGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG31</accession>
    <name>A0A367JG31_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RMT1_1</name>
        <name evidence="9" type="ORF">CU097_009317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01001394">
        <property type="protein sequence ID" value="RCH88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG31"/>
    <dbReference type="STRING" id="86630.A0A367JG31"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="160"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="337" mass="38280" checksum="0561BCEF1050DE34" modified="2018-11-07" version="1">MAASTPSHNVETMTSKDYYFDSYAHFGIHEEMLKDEVRTLAYRNSIYNNKHLFKDKIVLDVGCGTGILSMFAAKAGAKHVYGIDMSNIIHQARVIVKDNHLDDKITLIQGKMEEVVLPVDKVDIIISEWMGYFLLYESMLDTVLVARDKYLAPGGMIFPDKATMYIAAIEDGDYKEEKIHYWDNVYGFDYSSIKNLALKEPLVDVVDARNVISTACPFKEIDIATVTKADLTFKAPFKITATRDDYAHAFLAWFDIGFTHCHKPVNFSTGPHAKYTHWKQTVFYTPETLTLKEGESIEGEVSCAPNQSNPRDLDIIIDFKLDGQHGSIQDKCEYKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGM8</accession>
    <name>A0A367JGM8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001361">
        <property type="protein sequence ID" value="RCH89029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGM8"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="210" mass="24234" checksum="5390F588BB877FC9" modified="2018-11-07" version="1" fragment="single">MREPNFSFPSQSRAAVCITSALYDRRALDCTATLPLVNSLTHLAYLTSTSPRIREILCLDGGLERLVRILFNTSNRADRLTSWKWTLAFQTVVNVGVRGTEQIRTKVVDAGVIPFILTILSNTNKGLEQRIDHSKTSSIHNNTLRRSTFPYVKINAAQRRHRRIHKDDKKHIEDHVFHREEDILLSLQLLAYLSKYPHIRDLFHTAYDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGT4</accession>
    <name>A0A367JGT4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001350">
        <property type="protein sequence ID" value="RCH89095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGT4"/>
    <dbReference type="OrthoDB" id="2255066at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="117" mass="13373" checksum="6B78F1E36624DE5A" modified="2018-11-07" version="1">MQKRTLKRTKTNFGIATESQSSSSQPPVALSKEVRDKLFLADFFDLEPPCDWNVIHYLNKLVQKNPAISARPGNKALYDDADLMLKHVVPGTVAETMLRQMTRSQMCYLYRPQQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH90</accession>
    <name>A0A367JH90_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NME5</name>
        <name evidence="10" type="ORF">CU097_007712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001323">
        <property type="protein sequence ID" value="RCH89245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH90"/>
    <dbReference type="STRING" id="86630.A0A367JH90"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH89245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="60807" checksum="40EB583DF4006942" modified="2018-11-07" version="1">MISDIQNAYKIFDEEHKEDDLNNGAYDRQVQTQRTVAIIKPDGLSSKQKIIERIQSKEFKVLQERTLQLAKDQAKELFENQKTYEDFDKLVTWISSSEICALLLEKENAIDEFKFFLGPRNPKKAKKKKHATLHALFGTDSVHNAVDGSDSVEHAEKTIKLLFDGCQQPLKQNMSDASEEIKHEDMSDPLPSPIPSAVLKTDLALQADEEDVYVACTPQKPSEKYAVSVEENKPFHSNSDAYASDKTERHGLEESKFTQAASIENIMQHEASGTVAQVSISATVDNAVKKDNVSQNQIVAETAVEASPHNANDMVSKEAGNTNDRYIREVESINDKKGELSNVKKEISKEETQSTKGDKSKEKATVAIRVQQRASTTKSLLRQPSIRVGNVVDTTQKPVRRIECKPVPVTPPKNVKSTSKIAKLSPIMHKQESATRKPLTENAQKKKPTKVSKHLPRVALLASQKPKQEPKDEPIVEAKEVKTIKKKISTKEFISRLTAPTVASNNKKLAANQISVAQKITPQTKVNATGKSSKVEFLEQAKILKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHL3</accession>
    <name>A0A367JHL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TIF34_1</name>
        <name evidence="7" type="synonym">TIF34</name>
        <name evidence="9" type="ORF">CU097_009178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001289">
        <property type="protein sequence ID" value="RCH89430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHL3"/>
    <dbReference type="STRING" id="86630.A0A367JHL3"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="328" mass="36627" checksum="C5133CA34E1A2F25" modified="2018-11-07" version="1">MRPILLQGHTRALTQIKYNREGDLLFTVSKDKIANVWYSHNGERLGTYTGHQGSIWTIDVNADSTLLVTGSADNSCKLWQVQTGRCLKTWEFKTAVKRVEFSEDGSMVLCVTEERMGYSGTVTVYPINNDINGTQSDTPIVTITNNGGAKAVVAGWTYLDKYIITGHEDGTICQWDWKAKEKVKSIKAHDSVLSDMQFSIDRTYFITSSKDKSAKIIDSISLDIKKTYTADTPLNSASIIPKHQEFVIIGGGQDAMSVTTTSARQGKFESRFYHKILEEEIGRVRGHFGPINTIAVHPEGTGYSSGGEDGYVRVHHFDPDYYTFKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHR9</accession>
    <name>A0A367JHR9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_011508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001281">
        <property type="protein sequence ID" value="RCH89480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHR9"/>
    <dbReference type="STRING" id="86630.A0A367JHR9"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016959374" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH89480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="126" mass="13728" checksum="443A3A3E9F95BD77" modified="2018-11-07" version="1">MHFSLIVIALFVFVTVIQAASLEARGAKKSGHATFYSVNKSGKPSCGGDADNDDMVVALSKHRMGKGHKKPCGEKIKVHGERGFVTVKVVDTCPECDKNDIDLSPAAFKKIAHKKDGRVKVKWSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIB2</accession>
    <name>A0A367JIB2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LCHN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001257">
        <property type="protein sequence ID" value="RCH89609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIB2"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="63484" checksum="7027651718B4B7C6" modified="2018-11-07" version="1">MNDEQSNNVKKDQESHQESNVVAMFVVQFDVHKGNVLEWQYPPEFDLQGIEYQAICSGLHRIESDVVYFSRSSYYGISVFQNMSIDTSRGAYMKAVGLVVKPTKSTGACGNVWKHKNFLMQELSHFMTPSQSAEPTQYEGLIEYYNRHKYQERQVESDPIYMSWLHDKSLLYAAEHSVNFNLAHNIVSVNHDLMEASDLPEFVKLFGPDIFVLWKAALLRKRIMFIDVPPMETSCRYVYSMHLMGHIPDKFKSVKPIIPKFTVGVNDIPELEKSSDCYIACTPDTIFQIKSDLYDLMITFPTLPFSHPVTQTASAQQIALSDLRTKTGLEIKSSIPSVPSNHNPADVRRYRILQRLVENQSFDLGSKSSSSSLCVADFYYWLYEEQDELQNEQGELFCRSSGQGTARASSPSSRRESRELLADEEQDALEINPNEILEVVAARASSEMLRTSTEYQQQQSINNTLINFFQQLTFFLLLTLQDIISTNERDDITILWPKDMVELGLDPLKDTEFVIELARLYFNKEIQVRGIPDWHACCSACCLQGRDRQYIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIT6</accession>
    <name>A0A367JIT6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001216">
        <property type="protein sequence ID" value="RCH89858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIT6"/>
    <dbReference type="STRING" id="86630.A0A367JIT6"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="234"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH89858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="725" mass="81432" checksum="82D54466BA74A8DC" modified="2018-11-07" version="1">MAGPSEENEFRHQVQQFDFCGESIDTSLRKLLAKVQLPKEAQQIDRAMEDFATRYYECNPTLVDKPDVAYAVAFSILLLHTDAHNKNVKQKMDKDTFIRRTKIIEGGEGVPAEILDIMYDNIVISEFTYAKDITTRPERSNSWFSKLISDSTTVTSTNSTSNHTNAQPTTFADLAPKLEQLMPAENTFNYKRNILKPIPIMDIHFSLLTAKSLCLAGVRSKHGNNSNNNTFTIRVTKAGMLDRKHDLMHGGKRATARSWRPFGVILSGSQLIFFSDLSSYQQWLEEEEHTSKKPPRRNSSVPHSVSSMTESASNLSINNATVTSMTSLYSNSNMSTIPPLTTPTLSTPNTYLRPVQIISLSYAVCIHDEAYTKYPHVFRLITGDGQHFLLRASSDEDMDDWMLKINYASALKTTGARIRPFKRRSNDSTGSVDVKYSLEQQKREEEAKEKVQELSDRIEEQIRILDRELQLRRNLMVLAPVQKSTKDRLVAFAEMVGKRIRTKRIELQRLECYRDYLEAELVWCASSQQQSRKVSLATSSYKTTNGRTESFRKLSNLVFTPPSASTSTTSSSSTSTHISHPVSMHSHTPSSSKSDEDDAAGNNSNSSRSNSTSTSTSTTSSSDNNSINQASDTQDIQISFPKLRISINDAPERSAEMDRVMRRRSQSNPILPNKQKLSLLQPPNRNQRERSGSEASHVRAEDDDSMSVVIINDTEGTDSSLPSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJZ3</accession>
    <name>A0A367JJZ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">U3 small nucleolar RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">UTP4_1</name>
        <name evidence="1" type="ORF">CU097_000179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001151">
        <property type="protein sequence ID" value="RCH90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJZ3"/>
    <dbReference type="STRING" id="86630.A0A367JJZ3"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="313" mass="35780" checksum="A44DD44DE9918C16" modified="2018-11-07" version="1" fragment="single">ALSENAQWIAVADVEQVRLFRVETDEETGKLEVKKQRAFEKELNMYLNEHGAAAGAHHVRFTPGSDKLIIVTAESRILLVDLTSWTIEKYPVLVEFEHHRGLDSDGNSADDHAVATVISIDISSDGQWLVTGDDNNRIHVFNLDNFKHHLQLPQGNIPHTALSFNQFRPNELFVALATNAFYIYDVEHKKLTNWSNIHKDMSHCRLLEQRDRIRGVAYNPAHENKMIIYGSTYMCLADIEYKPVSSKLGKRKQEEMPSIKKEDALAFPISHQYQQILYCGFIAKDQMVMIERPKFSVLENLPPSFYKAHFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKG3</accession>
    <name>A0A367JKG3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001127">
        <property type="protein sequence ID" value="RCH90406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKG3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="65" mass="7700" checksum="DE15384321D2CBF8" modified="2018-11-07" version="1" fragment="single">MSKQDLKDIIDRLDHFERNRQPTIPISDVRHACVAAIIRWRPFIDLNSNHDPLPSTVSEFFNEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLJ0</accession>
    <name>A0A367JLJ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001071">
        <property type="protein sequence ID" value="RCH90765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLJ0"/>
    <dbReference type="OrthoDB" id="2282637at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="148" mass="16919" checksum="D0AD32A9C700B05D" modified="2018-11-07" version="1">MDAIVAETFSKWYIYLYDSFGVQFHAPPPAQVFQCVSNLFNILYIHSPPIVRTYYNILNNIPVQSDIIPIALAMLILYALFATVVMTIRGIVRLVYGFIRFSMIISIIAAMICVVLPYINQLERNSLFSFESFVFSASPTHTLERQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLJ1</accession>
    <name>A0A367JLJ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACU9</name>
        <name evidence="12" type="ORF">CU097_010607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="PJQL01001103">
        <property type="protein sequence ID" value="RCH90561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLJ1"/>
    <dbReference type="STRING" id="86630.A0A367JLJ1"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="172"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="423"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="550" mass="62039" checksum="5088C0728221D11D" modified="2018-11-07" version="1">MSVAARSASLLKSTVPGVAILAPVTAAETEILSPQALQFVATLHRIFNPTRKTLLQKRALRQQELDRGVLPDFLPETAYIRNDPNWRAAPPAPGLQDRRVEITGPVDRKMIINALNSGAYTFMADFEDSSAPTWENMISGQVNLRDAVRESISFSNPNGKKYELRKDGKLATLIVRPRGWHMVEKHVIIDGEPCSASIFDFALYFFHNAKELIKRGKGPYFYLPKMESHLEARLWNDIFNVAQDMINIPRGTIRGTVLIETILAAFEMDEIIYELREHSSGLNCGRWDYIFSFIKKLRQHPEYVLPDRSAVTMTVPFMDAYVRLLIQTCHKRGVHAMGGMAAQIPIKDDAKANEAAMNKVRTDKLREVTAGHDGTWVAHPALVQIALDIFNEHMPQPNQIHVRREDVQVSSLDLLNVNFKGAITEKGIRENIQVGLAYMESWLRGTGCVPIMNLMEDAATAEISRSQLWQWARHKARTSDGKVITGDYLLKILDEETDKIKKNLGPKYASSKYEAAKRIFATNVTGERYDDFLTTMLYDDIVTIAPSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLM9</accession>
    <name>A0A367JLM9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001058">
        <property type="protein sequence ID" value="RCH90850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLM9"/>
    <dbReference type="OrthoDB" id="2231406at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="193" mass="22854" checksum="E070C86DC4F5016A" modified="2018-11-07" version="1">MSEEEDKRFEDLPQVEQLLEDFKALKILKEIEETQRNIDHEMQEYEQRHVEQFQSSQSELERLRTKEASVIEEYKTMLERDKQTRLENESMEENIQQLDVQITELQREKELLMKQVQALREEEFSPTNIPSTELTLALFEGLGVKPVMEDGQVKKLILETQDKSNSCIFDVTERSASYNTSFIWKFLAKGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNF4</accession>
    <name>A0A367JNF4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">CU097_012252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000968">
        <property type="protein sequence ID" value="RCH91456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNF4"/>
    <dbReference type="STRING" id="86630.A0A367JNF4"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH91456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="206" mass="23355" checksum="3C9E25C1B29401F8" modified="2018-11-07" version="1">MLRILRPLHKPFVAHTRCLSTVTERQLTKEEKELITPMIRVDQAGEVGAYYIYKGQIAVLGQDKNLKPILQEMWDQEKLHLERFNQLVGEHRVRPSLLRPLWEVAGYAVGYGTALLGKEAAMACTEAVETVIGGHYDDQLRELVTIKEPNQQLVDLGKTIAKFRDEELEHHDIAVAHDAQLAPMHSVMKNVIMQGCKVAIWVASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNQ5</accession>
    <name>A0A367JNQ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_011910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000983">
        <property type="protein sequence ID" value="RCH91341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNQ5"/>
    <dbReference type="STRING" id="86630.A0A367JNQ5"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="316" mass="35726" checksum="43DA1E67C6F20B1A" modified="2018-11-07" version="1">MYSPTQQDFNLEPDHFSSSGMMGTPHTTVGAVPVARNSRLFNASYQLHQRQNSFGTVASITMSPPHRAGGLPYDANNSQNWFGTSLDSNASSFGQSPIFTGIVSPSASTGHLDNYTNDDEEIQQKNLQEIFEKRRRRRESHNAVERRRRDNINERIQELCTLLPERLIEAAPTSSNVMSVSNGQGGTNGRAINKGTILKLSVDHIKELREEVTRYQERIRELEQMIEAAKRGEMIKDDKLQQSTNCLYHNSQIPPNNINTANNNNNNNNNNNNNNNNHNHNNNNQPPPSHHHQRMGSLQFRQQFNNLQIGSNNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JP08</accession>
    <name>A0A367JP08_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SCS7_4</name>
        <name evidence="23" type="ORF">CU097_011581</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="PJQL01000933">
        <property type="protein sequence ID" value="RCH91700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JP08"/>
    <dbReference type="STRING" id="86630.A0A367JP08"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCH91700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="343" mass="40318" checksum="11BD50346DCD5072" modified="2018-11-07" version="1">MSITFKRDEVKKHSTSDSCWVIVNNKVYDVTSFLQDHPGGSEYILEFAGKDITSIMKDSVYHTHSDAAYDVLTEYYIGEVVKDDHVQERNVIKQAVNANKIGSQRDQEFLDLRKPLFSQLWNATYSKEYYLEQVHRPRYTPYTVPYFDNPYLDMLSKTNWFIVPVLWLPFVVFQLWKSLNCAYGSIQVTSQGFSIGILFWTLLEYVLHRFLFHLDKLLPDHPIALLVHFTLHGIHHHMPMDRLRLVMPPILTIILSIPVFQLAHGLFHPPLAYSFVAGAFFGYVCYDMIHYYLHHANVLKIYFRELKRYHIAHHYKNFDSGFGITSKLWDYVFGTVLYLDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPY1</accession>
    <name>A0A367JPY1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_010480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000899">
        <property type="protein sequence ID" value="RCH91945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPY1"/>
    <dbReference type="STRING" id="86630.A0A367JPY1"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="236" mass="27869" checksum="53FEA6B6D3E5032F" modified="2018-11-07" version="1">MDKDTSTVKLHDQDDKVIKKREISNQPNMSQPNGRDQSKQKVYNGLAQKTVQELASYQKRMVEKGSKRIFFRRQKRSNRPPPPVPDHEKSSEQLEMERVQKQKDVLDYEDKITYSSRYFDDIYEYRHVILPLEIARWLPHHGLMTEEECRALGVSQSVGWQHYMVHAPEPHILLFRRERGFLEKYPELAEKMKEEQEAKKKEKEEELINARARDESMTALSESSNAKPDAFVPEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQJ6</accession>
    <name>A0A367JQJ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_003937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000869">
        <property type="protein sequence ID" value="RCH92155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQJ6"/>
    <dbReference type="STRING" id="86630.A0A367JQJ6"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH92155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60907" checksum="AAD35B4DB24C0E76" modified="2018-11-07" version="1">MTSERVVSFQELVDLIHNDAQVALDHPFIFKKPIKNVAVIGAGPYGLCSARHLRDAGLNVKVFERNSSVGGIWKYSDTAPPKPKMPTSRISLDDGNTDDVPKDGTKRTRMYEITPELRQRIFRKCPPSGCYRDLFTNIPSQHLAYPDFAFPEGTSGLVTHQEMLAYFERYATTFNLMKLIDFGTSVDIAAKTTDDEWELVLSKYDVYPSGFVKETKWREKFDAVVAASGVHQEPYVPDIKNLTAFNKMWPVKVAHSKQFRRPEDFKDKNVLLIGVRVSGVDIARSLEGFAKSITMALKGNFTTPFPVENIIRAKIPKCVDVKCEVASFSNPEGEVDGSITFQDGTVLKDVDQVIFCTGYTHSLSYLDGLIIREEEYQSSAKPKFIDVPPSHIVLGRKYPLNAYHEVFLMSDPTLCFVGMPRMFSITPYFDTQAQVVARVWSGNACIPTAELMCQLADSFNPGLPLDDLYACDRRRREIYVGWLNYQAEKLGKTDLPKIKNFEESYEEEGAQLANAWGDLSEANFQNAKQRVLNELEGMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JS22</accession>
    <name>A0A367JS22_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000799">
        <property type="protein sequence ID" value="RCH92649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JS22"/>
    <dbReference type="OrthoDB" id="2398733at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="99" mass="11442" checksum="075576D5F64AA580" modified="2018-11-07" version="1">MISTPTGYLFQQQQQQPQMPYYQQYNTNSQQSSMSNMHIPPNFGLSTTTNQTYQPRHPPVDASTLLKGTQIRRVECPVCQKMLEGDDMAINHHVNEHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT56</accession>
    <name>A0A367JT56_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_007468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000734">
        <property type="protein sequence ID" value="RCH93152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT56"/>
    <dbReference type="STRING" id="86630.A0A367JT56"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38600" checksum="750438D7F54C6F77" modified="2018-11-07" version="1">MAILSENRRRSISGASALLTRRFSRQTTTNNSKPDIVRRRATIAIKPPKVHVRIVPSIDNPGRSLIFDIVDRNLEYGTIIKIGRYSERNPNNSDCMSFKSKVVSRCHCEIFVEQDGKLYIRDTKSSSGTFLNHIRLSPAGQESQSVEIHDGDLVQLGVDYQGGREEIYRSVRMKFEINHRHRPRPVSFSLTAFQNLRSLTTSSSTDLDECCICLYSLAPFQALFVAPCSHTFHFKCIRPLFQSYPGFQCPMCRTYSDLEASVDHQVIEENDGHDTMHHQNNNNNDDEFNLQSSPIFIQSDDGVPLETNNINRISTAVMDSPSHQGELYILLLPSLSDLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTJ4</accession>
    <name>A0A367JTJ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000720">
        <property type="protein sequence ID" value="RCH93257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTJ4"/>
    <dbReference type="STRING" id="86630.A0A367JTJ4"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12344">
        <property type="entry name" value="RRM1_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000405">
        <property type="entry name" value="polyadenylate-binding protein RBP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="211"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH93257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="315" mass="36052" checksum="2BF212D5BF7F7B1F" modified="2018-11-07" version="1">MSLPIEFSSEPKTTLWMGDLESWMDEEYIQQLWFNYLGIHVPVKLIRDKKTTAGYAFIDFSSCDIAQMILDRFNGVLLPNSNKSFKLSWASGGLVDKRQDNQKEYSLFIGDLDYNATEDDILFIFKSRYPTCKSVRVMTNYDTGFSRGYGFVRFTDPSEQQRALVEMQGQVIGSRAIRISFATPKKSISQDSSLITTPTDSPLLQHQDTNTTVFIGGLSVPITEDQLRQYFTPFGVIVYVKIPQGKGCGFVQYTTRSSAELAIQQMNGYQIGNSNIRLSWGTRNHQKQADPSYFSLQQQQKKAYNYWMDDQIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUI8</accession>
    <name>A0A367JUI8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_007408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000709">
        <property type="protein sequence ID" value="RCH93351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUI8"/>
    <dbReference type="STRING" id="86630.A0A367JUI8"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="2">
        <location>
            <begin position="110"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="586" mass="68239" checksum="A22DCBD4505CA9D1" modified="2018-11-07" version="1">MSSLIPPSPSRRRRYEALKQISWTLDNAENRVAQFDAPETDEIASEDDMIVEYELVDEQNYIAYQELEEDEDMQMTQEIKDDDVDMQLTQEITYNKPVKDAVIQEETTTTKDKPSLEDSEQTTLADFLEMAGITFPRQIPLNDIMPISIVDVDYESPTIAEQAAAAAFTLPQIDMYDSISKQMHSLIDTSQDVIQKVEDRVNRTSTEFFSDYLRANASTRITMEPEYRLTKQYAELKSLERWYEWCVNIFVEHLGTLKGHINALTQDRQTLASLEDELRGQLPKIVEYQQGISQLLAEAHEIEKEYRRFDHKKLSRMRDEIEHQRQTIELFNKDLENLGAEEAELFERIDMLEHRKSRLIKDTVDAREITSMNHIITENDLNLVRQLYERSCNVGGLKLLKDNEDDDTLEILVAKCLVLTIHRNDLKERKENAVLFHIKNNKINGYEYITHFRRGLSAIVKSNQDTNQIIQEITIYWNRVQMLVDVLKETELRFATTIHPIETNEDIESGISCSIDVASKKRRQKIAIKFDIRVRNILQFPFIDDSSIQAKVCFNSLMANEIEERFKEYLNENGILDLVDGITSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV07</accession>
    <name>A0A367JV07_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SWIRM-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_009985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMARCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000667">
        <property type="protein sequence ID" value="RCH93689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV07"/>
    <dbReference type="STRING" id="86630.A0A367JV07"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="280"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH93689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="63580" checksum="143F659202477730" modified="2018-11-07" version="1">MSTSKKPRLDKDNTTRPFIPVQQYEVIIPSYAAWFDLSTIHINEIRGLPEFFNNKNKSKTPSIYKEYRDFMVNTYRLNPLEYLTVTACRRNMTGDVCAIIRIHGFLEQWGLINYQMDPTAKPTAIGPPFSGQIKIIAEIPKDLQPALSENQQSTDEATADATIETNMATDKGAPEETVKTPEPEKEIKTEGPGHIKTEEASSIKQEISLNLDLREDIFNTAQKRHLQKKTIKTCECCKKSQNIYEGYRHESMFVCSECFEANKLPEGTKKEDFDKEMKHEEESLEDTWTEQEDLLLLEGLEMFPMDWNKIAEHVSSKTREACILRYLKLPTADPRIDPDIKHRGLLDFDAKDKVDNPIMSVVAFLASNVKPEVASSTIHERQDNDAEMKEKEEEDNQQLRADLLHSKVSLFSARLRQFREKEKLIDLERREVEYERWRAQEDLCFLKNRIDSIYARMFHASQAKIAAQQQQQEEQMPENAIVYLLDDPTLTEEQRKEQLELKQRYPKQYESRQILLQQQQQQQQQLQQQQQQQQLQQQSNGIQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV16</accession>
    <name>A0A367JV16_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000666">
        <property type="protein sequence ID" value="RCH93699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV16"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017025714" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="53" mass="6202" checksum="D1E560A543D0180A" modified="2018-11-07" version="1">MNKFYLALYIAILLNALLVFARENPQNDKRIIAQRRKRGLSRRATTICPYFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV81</accession>
    <name>A0A367JV81_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000681">
        <property type="protein sequence ID" value="RCH93571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV81"/>
    <dbReference type="STRING" id="86630.A0A367JV81"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11107" checksum="C1FE913FAC7489E0" modified="2018-11-07" version="1" fragment="single">VARLLAAKTALALRVDALGETESNEIGADGRSKVEARIDLLEGRFAAKANKDTSIQNQSKFKLNKVQAYNDSADVAMTEAAPEAETSAKKRKADEVEEDEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JV89</accession>
    <name>A0A367JV89_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000642">
        <property type="protein sequence ID" value="RCH93902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JV89"/>
    <dbReference type="STRING" id="86630.A0A367JV89"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.890.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016089">
        <property type="entry name" value="Chalcone_isomerase_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="276" mass="31381" checksum="27078D32A4D1C9BB" modified="2018-11-07" version="1">MFRFSRSLLNAAKGTTFRTFQRQYVTTFPKKFQASNSKLLLGATVGIGFVGTCLALQEPVSAEAPGYAGTVEDPASKLSFPIFLNTGNSEWKKLIGLGVRTVTFLQMHVYVLGLYMKTDDIESLKNLNGFKEFDRQKFLKNEEMANNLVDQPYDISIRLVPVRATNTQHLRDGFVRLFMQRLKTQSLTEDEEREVLKAIQDFKSKFVNMNVKKHTEFIFTKTKEGGLKIVYEGKEWGTVDNKWVAKNFIMGYLSPISPSSEAALKDITDGFERLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVX8</accession>
    <name>A0A367JVX8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">High-affinity Zn(2+) transporter zrt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000611">
        <property type="protein sequence ID" value="RCH94152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVX8"/>
    <dbReference type="STRING" id="86630.A0A367JVX8"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH94152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37587" checksum="C6FF4620AC7ED748" modified="2018-11-07" version="1">MSFQAAAFAFLFPGNAMTNSILATAYISIFPNLLLYFVPPDIDTGALNVLVSFAVGGLLGDVFLHLLPHAFLGEHTEENAVITIDNQKNVLIGTGLFVGLFFFFFMDKMMRVVNGGSGHSHGHDHSHSHDVKEVGTSSSVKNDDNEKKGLRQRKTTDKKEEEQDKMTAKNQQGIKLSAYLNLLADFTHNMTDGLAMAASFYASPAVGATTAVAVFFHEIPHEVGDYAILVQSGFSKKKAMMAQFTTAVGAFLGTFIGIMIEESSLSSGVQEKASAITSTGLLGTDLRVGDLVIPFAAGGFLYIATVGVIPELLDVTGNLKKDRKQAFTEFAAMLVGLGLMFVIAWNDIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX38</accession>
    <name>A0A367JX38_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000579">
        <property type="protein sequence ID" value="RCH94429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX38"/>
    <dbReference type="STRING" id="86630.A0A367JX38"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="171"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="481" mass="54236" checksum="83C5230C1C77BB6C" modified="2018-11-07" version="1">MHGFGKSLELKINVLSDEVVLLGQPQEAAGKMLQGTLSLNVNEPIKVKSINLSFIGKMKVSWSEGVGHQQHFHKQERTIISHHWEFVGNEQKKSQVLNAGKYNWVFELMLPGDLPQTLDSDVGSVSYRLKATVERTAFVQNTVKKKVIKVLRSVLPSEFELIQSLEIHNTWAEKMVYDISVPSKLYAFNDKIPITFKILPIASQLKVHALMASIKEYCTYTANDHTKTDTRIIRLIRQDSPFVEPISVERPTWEKTLSLEVPSKSPMVFADADSDMIRIRHRLKFVISLVNADGHISELRCAVQIIVVESFVAAQEMTTLPAYDEMWRSVPYDPSVVERLRARSISEAGNNEPPLLLPESDREPVTISGWSRLLSVSQSSVPTAVSCDQVPHSQPVAIPGSNSGSRHHSRRPSVDEQDLADVPLNELHREDQVEEEHHWWDEVDLGKVPSYRTVGTNLFPYSLPPAYDSVSNRFDHSPANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYG3</accession>
    <name>A0A367JYG3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Suppressor of glycerol defect</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SGD1_1</name>
        <name evidence="6" type="ORF">CU097_012673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000549">
        <property type="protein sequence ID" value="RCH94691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYG3"/>
    <dbReference type="STRING" id="86630.A0A367JYG3"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="655"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="874" mass="100754" checksum="113EFB6694E673A0" modified="2018-11-07" version="1">MPHKRGPTPGSVLPKAMKEEVDAAEKDDRKFGKKFVNKIANRKELRKQKRAEKGKRKAIHQQTRDQQNKKRLLSEKQPQPNKRQKKEDLPKDQSKDQPKKQVTNSEEAEKRLSKKNPALYKMLAADNLVGKNSTTDEDFEEDDKEIAYWEKKLGLNKKKKKKLGKEFENDGLLDVLGNVDNVNNEMDDIEYLKQKRSKQAQLKEQKSLEENAERAVDQLFEDFPSDEDDDDMDASVDEDMSDILNDEQESGEEEEVSDALEDEQDDDDDDDDEEEEEEEEEEEEEEEEEEEEEENDEENDEENKKEEQVVVKEPPKSSVLTKYVPPHLRKPVSTGKSEQQLRLQKQLQGQLNRLSELNIESILVEIEKCYGTYPRHDVTSTITELIINSISQRSNLLDSFVITYATIVASLYRLVGVEFAAHFVQTVIEMFETEHKKYKKAKQQTIDDEQEGYKETRNLLTLILELYNFQVISCILVYDIVRMLINELDEGNVELLLRIIRTAGAELRNDDPTSLKHIIDEIQKETAKRDPSTISLRHKFMLETIANVKNNKIKNKQTAAGHGDKELVQKMKKFIQGLSKKRSTRSTEALRVSLDDIHNVHTKGKWWLVGASWKDNLVGTESKYKTTNVPEDLKKDQSMQEALLKLARKQGMNTDIRRTIFITIMSAEDYLDAFEKLMKLGLNEVQQREICRVMLQCTGNEKTFNPYYMLVSRRLCEIDHSFKVTFQYCLWDFLRECGESEVGGLERSASESFSGSKEVRLSKIVNMAKFYASLITEGALTLAVLKSINFMNLQKNGRIFLELLFVNILLQLHAGGAQAIANVFGKIRDQRILAQGCIFFIVGTVTHCKHSGLEEDDIEKVQWGCKIAKEVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYJ1</accession>
    <name>A0A367JYJ1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NTH1_1</name>
        <name evidence="7" type="ORF">CU097_008029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="PJQL01000511">
        <property type="protein sequence ID" value="RCH95024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JYJ1"/>
    <dbReference type="STRING" id="86630.A0A367JYJ1"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="778" mass="89553" checksum="C69D6B2D8A80C09F" modified="2018-11-07" version="1">MQQLDSVNLDLIDIHAPAKTYYTTGNNAGNAINRLRTFSGHQSVSKFSETNAQRKRRASHDAKNKARKFLLDVKETQRILVEQEDTDGDFQITVNDLGPKSLAVGSADSGGYRKIEIRGTYMLSNLLQELALAEDCGRKYIVLDEARLSENPVDRLSRMIRYNFWDGLTRHMDAEGLEKICMDPKNRSANHNPRIYVPFDEDQVFDYYQHVAQTKPHLGLEVERLPKDITPEYVQSINDRPGILALALKTSTDEEGNTVFRGVPFVVPGGRFNEMYGWDSYFEALGLLVDERIDLAQGMVDNFTYEIKHYGKILNANRSYYLSRSQPPFLTDMAKQVYMRLPKTEENKKWLRSALQAAIKEYDTVWMAEPRLDPKTQLSRFRPDGKGIPPETEASHFDHVILPYAKKTGLSIVEYMRQYNEGVIQEPELDEYFLHDRAVRESGHDTTYRYEGRCANLATIDLNALLYKYETDIADMIEQDLGGYLVDYQGSPQDPQVWRQRAEQRKTRINKYLWNEEAGMYFDYDTIAEEQSNYESVTTFWAMWAKCASQEQAEKMVRMALPKFEVTGGLVSGTAESRGEISLDRPNRQWDFPFGWAPHQILAWRAFENYNMQPIALRLAYRWLYIITKSFVDFNGVVPEKYDVVSLTHKVQVEYGNVGVDFKYVPREGFGWMNASYQIGLSMLTKQMRRALGTCTPPAVLFEKYHERSMEDTAKAITQNGQTTTAITVIDPDTIITTNKMKPLEIIDTTLFLSPEESNNDEDTFYDALSTSYNEEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZR8</accession>
    <name>A0A367JZR8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_008669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000469">
        <property type="protein sequence ID" value="RCH95418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZR8"/>
    <dbReference type="STRING" id="86630.A0A367JZR8"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH95418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="320" mass="35594" checksum="343220BA83B72E85" modified="2018-11-07" version="1">MKLDTGQPPPPSSIPASPHKGCNSSTCCSPARLWRTLQNLIKQNDRKGLLAFFKDPRLEHIVRVALTSRVSNDGSLLPASQRHTLVRFASPQLATEALPLLGKRLTDLNALQLALLESSESTVMALLTQLKLHASTEEMKSFVQHVWGQGNTSLHLAVFLNRPRVVKALLDLGASVDCLNAKQKSVIDCCRDQSMLDILLPPQKKKVIQHELPNMEPMVVKDEPVVAKDEPMVEPMVVIEERVQNTISYNNDNNNNESATLALDPYLLLLKHHVQQQQQFNTSTATIHHSCAQTVISQFMKQSVYLSQEKKPPDILLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZS4</accession>
    <name>A0A367JZS4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000464">
        <property type="protein sequence ID" value="RCH95464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZS4"/>
    <dbReference type="STRING" id="86630.A0A367JZS4"/>
    <dbReference type="OrthoDB" id="18145at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH95464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="831" mass="95892" checksum="20FBDF6F6A1A7108" modified="2018-11-07" version="1">MSNELSSSHSSPEQKVLIKAEQYTDLKADINIGNYDRALQTFVSLQSNDYRNPAFQAFAAEVAENLDPQMETDLSKFFASLPFVLQSNIIDFAKEHFQGNGDYIKIFNILFQYIKSYPLHAYKYLIEAINTLILSAQKMEGEEKQRLIKTLVTELFPRLCDYKLLLVRRDIVPSVRNTNEPLICLPYNLFEQFLLLGQRFYIKQHKWKEATQFTCSMLAACGYKGLDDENYISHHDLRLQYLKEHRNTVRVDREELEVDALSVDDFVVLVTVMCEYMAASCQFVQFGYDYYRAVCGMNGENTDDEKSCLIPICIFQPNNNNKPGTGNDKTTIDFSEDTQMTARRKRPRLDYAEDNEEEKIEQERNQGLNSYCVKGVDDTLHILSQAGDCLRHIVELWQWASDRIPENELVDHFGNWEQELCRVIESYKLPFDMHNAVLLVRSDLALSSPSVPGNLAKALELSQSICDRIDAQRREEKTHGESVDADIPLMFTFRVLYNIGIIYLLVGSLQQSTLEIAIILSVFPIPDELEEKDFLMDEIDCCTVANIFHGREFGLMRVTQEGLVVRCIKHLVVGLDNESEQKGGMASIDSALRWDEKAGNMIVMMQYGWPYWYKRTNLWQKIISKISEKRIFKNREFLEYLYVSDVLNAILQLHLTAKVTMDIIPPEFALRGSYKHLVTSENSSRNTTNTNDTPSDQSNEAQNEEDHEIATRRHLPLYQPTFANTILPSTSMSPSWYSASTQKNSFAQWMSPSFYYSRPATSVILPDAEERGPNDDGQTAETKGTYVPREMVTRCLEYRIRKYPPKITPQRMRHVLQRFLKNMVLKANEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZV5</accession>
    <name>A0A367JZV5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TEF1_1</name>
        <name evidence="11" type="ORF">CU097_013742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000461">
        <property type="protein sequence ID" value="RCH95494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZV5"/>
    <dbReference type="STRING" id="86630.A0A367JZV5"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH95494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="458" mass="49875" checksum="0A65BFD917E7164E" modified="2018-11-07" version="1">MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYNVTVIDAPGHRDFIKNMITGTSQADCGILIIAAGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAINKMDTTKWSEARYNEIVKEVSSFIKKIGYNPKSVPFVPISGWHGDNMLEESTNMPWFKGWTKETKAGNKTGKTLLEAIDNIDPPTRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVTFAPANVTTEVKSVEMHHETLAEGLPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAKESGSFTAQVIILNHPGQIGAGYAPVLDCHTAHIACKFAELIEKIDRRSGKKLEDAPKFVKSGDSAIVKMVPSKPMCVEAYTDYPPLGRFAVRDMRQTVAVGVIKSVEKVDKAGKTTKSAAKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZZ5</accession>
    <name>A0A367JZZ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rhizopuspepsin</fullName>
            <ecNumber evidence="3">3.4.23.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_007082</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000453">
        <property type="protein sequence ID" value="RCH95562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JZZ5"/>
    <dbReference type="STRING" id="86630.A0A367JZZ5"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016958664" description="rhizopuspepsin" evidence="13">
        <location>
            <begin position="22"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="81"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH95562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="388" mass="40424" checksum="478F9A951F0C6E37" modified="2018-11-07" version="1">MKFTLISSCVAIATMALAVEAAPNGKKLSIPLAKNNDFKPNAKRSLLKALAKYNKTPKGDEISPQSTGSVPVVDVGSDLEYYGVVTVGTPGVQLKLDFDTGSSDLWFASTLCSTCSNSHTKYNPNKSSTYKADGRPWSISYGDGSSASGILAKDTVNLGGLAIKDQTIGLAKRESSAFAEDVIDGLLGLAFNSITTVRGVKTPMDNLISQGLISRPIFGVYLGKASNGGGGEYIFGGYDSTKFKGSLTTVPIDNSEGFWGVTVKGTKIGSKSIGGSFSAILDTGTTLLLLPDSVAASVARTYGASDNGDGTYTITCDSSKLQPLVFTLGSSTFQVPADSLIYEKSGSKCIAGFAAGGDLAILGDVFLKNNYVVFNQQVPEVQIAPIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1I4</accession>
    <name>A0A367K1I4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial acidic protein mam33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000401">
        <property type="protein sequence ID" value="RCH96102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1I4"/>
    <dbReference type="STRING" id="86630.A0A367K1I4"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29422" checksum="4DCA93B27750F568" modified="2018-11-07" version="1">MVTFIKGLFPVVSRVTRVPAVRYQLNPLRALTLSIPRLSSGEVDSDLAHQLHEEIQFEESDKNEPPAFVKEFLDANIFQIEDKEGSDKVALRRSFGNEKVSVIFSISDINKIVEEEKGEVIPEEDEYVELKKPEDKSFPVRTTVMVEKEDKGSLVLNTIAQDGYFHIQGIRYFRKGEIDHHDIFRHDIGEQRQDLYMGPLFEELSQDLQATFTGFLEERGINAALATFLPDYIDYKEQKEYVRWLKDVNEFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K369</accession>
    <name>A0A367K369_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_010033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000349">
        <property type="protein sequence ID" value="RCH96653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K369"/>
    <dbReference type="STRING" id="86630.A0A367K369"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="561"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1046" mass="117947" checksum="34B102B6232D7431" modified="2018-11-07" version="1">MSSAVELSSEQSANNHYKAFIDLFRIKCKLNSDRIFVRYYFNNAYKALTYAECDRITTNLACKWAAKGKGVECISLIGDHSVDYLIVMLALLKLRSTLLAVSPRNSEPAIINLLEKTNSKLFLATAKHESTAQSAAAKMGDVEVITIEPLNIEELLLEPLVPEHDKLLDSEFTDADLEKAALIIHSSGTTNFPKPIYLSNRGLLYITGFPDIYKEKYNIQMGDVNDVHLYCLPLFHLFGVFGLAHTVVTGASIVLLERLPPSQKEIDFALRENKVTVMAAPPVILEQMIPFLKESNDFSAVRRLKYVFFGGAPLKREAGHWLYSHGINIRNLYGSTEMGVALASNLNPSSDNWYSLGPYLNDSDGNPYFVFEDAGDGLKHLYLRHDSPTMALGVSNRPGGGFDSNDLFKEDPDHPGFYIYVGRRDDTLIMENGEKTNPVPMEATIRSSPMVKQVAVIGHGRQCTAALVEVDLEYAMNYEPGEIISSVHEAVEDANKECPSHSTILPQMVKILPFSKHLPSTDKGTVMRKKAEAVYKDLVDQMYQEFLDGPRSNGTLNGDNATPEQIESFLVKASSEVLRLPESAFNDYSRSLFDIGLNSLTAIQLRNLISKQFGNVPQNFLFQNPSIYAIRDALSSNKQVDAAELVETRYQETQELAKRYIERAKSDFPVAEEHYDEAQDKVVLLTGATGSLGSFMLRDLLKDFSVKKIYCLVRGKQEDLYQRLVSSFKSRCLDVSLLNSDRVEALPMRMNEPYLGLTKEKYEQLRNEVTIVQHCAWLLDFNMTIGHYDKECISPFYNLLKFAYREVNPMHVYFVSSISASAASGAVVEEKPLQFDSHVAMPMGYAQSKFVCEMLLNYLTKEKNFPCYVERLGQACGDAENGVWNTSEQFPLMFIAGGSLMHKMPRFNTNIDWIPVDYAATAMVDIMLRTSCLPSRLDDSIYHIVNPRNIKWPDILEAMSSCGMKFETVEPVEWIETLSKDDTNPAYRLMSFYEDMFKSGLRMPLWETSKTCQTTPVLGKSPVLDAELFNKYLKHWQSVGFYNPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K393</accession>
    <name>A0A367K393_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000351">
        <property type="protein sequence ID" value="RCH96630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K393"/>
    <dbReference type="STRING" id="86630.A0A367K393"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="493" mass="56360" checksum="34D9C16679604F3F" modified="2018-11-07" version="1">MYDDDEEELELLRQYEEENIVGDGQDTYSSEEMDSDLEEKILSVTHYDVGVDKKKKKTESAAIERSTLTAPASAPDARGRVLPSKSARRTVSTVHAPIDLDRKRADFSAASELKLNSSDEEGEYRSEEEKEKEMADVVASDSSSEEEELREAPPPVTRHINLDDKQYMDDVETSEEERELGAELRVLIDDSIQARGGQSRLGRPPNARVIICYRCKQPGHQQQYCLMCTECGLKHRGPCMWPRYCKLCKMDDHYKEDCRGKRETHDCELCGDKYHNTEICTKMLHIYDGEKPASKNMTIFCYNCGDYDHFGDQCRRYAYNSIIPSVFSEQSINYSELNKNRKKSNKRKRREHYYFESDDDDVSRKKSKSSRDYRHPSSSNNNNNNSSSSSHRMYNKGSPSSSSTTSSVYSRDEGKKRKKGKKVLDDFFGKQKGNKSPGSNQPITGNSNWKAINNYMNSLPQPSRSGTVQLNKNKNNRERADLPKPSKSGVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K3E6</accession>
    <name>A0A367K3E6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_006036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000372">
        <property type="protein sequence ID" value="RCH96401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K3E6"/>
    <dbReference type="OrthoDB" id="2219121at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016735833" evidence="1">
        <location>
            <begin position="17"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="249" mass="27478" checksum="DBED521C66BA0D96" modified="2018-11-07" version="1">MLLLVLFFFCFQGLLALSTFNVTLPEPNAPYVAGQMLPISYTLPDDPNLSRTLHLSILFTTNDPSLNHTELVITSNADTSQSFTFRRVYNTTVYYEHQLSYSIPNNTHPGQYSIVFVDSITGAKESVPITVRPYASPAPPARPSGKPFFVISEAPAYAVKLGNLNCLKKATSIDRQQPRKEEFLNENVHDADSRIQLESASSSDSKLPDCNLSTVSSVKTTKFSGNFVNGGGPISVTYHENVMNLQLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4E3</accession>
    <name>A0A367K4E3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000309">
        <property type="protein sequence ID" value="RCH97084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4E3"/>
    <dbReference type="STRING" id="86630.A0A367K4E3"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="161" mass="18594" checksum="B646AB9A8A2122FE" modified="2018-11-07" version="1">MPTYNNIRILHATTPKYFEKCLEVRQEVFINEQKHSIAIERDGLDDICQHWVAVCDKVNEDGTIDADYPIGNVRLMPKPDGVAKLGRLGVLSSARGLHVGQMLVKAFIEYCKKNEYTTIVLHAQNDKRGFYERVGFKVEEGDDEIFMESHTPHVRMWMRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4I0</accession>
    <name>A0A367K4I0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_012430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000313">
        <property type="protein sequence ID" value="RCH97045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4I0"/>
    <dbReference type="STRING" id="86630.A0A367K4I0"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH97045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="564" mass="65697" checksum="5EB4969C9CC317AA" modified="2018-11-07" version="1">MQTKECRISDVEDTDEESEWDYESSSENEEDYSEEYNYFDPTKITTSLPLLPFKNQVGGHASFFRFSKRAICKPVSAREQEFYEHIDSQHHELLPFTSQYMGVLNVTYRHNNSNDMLVPEVLFEKNKHLLRDWRACAYNKKNRDIKRRHSGSWDDGCRKRFQEQVLREVFSPKALKERLVQAEDWRRKVNANQPALMHSFSEHFPSKQQQHYSLVEGGRSMPNISGFKQDSSIDQMTIEPRRPSMINSTGSSPRLQHKKNLSEDENIFVMDDILVEKKKAVESPKAPPPILQVDSSCLQQIQVDQTTDNPWSLQIYNRDLQRIKSRKQSSEQKYILIEDLTDGVKYPCVLDLKMGTRQYGVYASREKMKSQTIKCEKSTSKVLGVRVCGMQVYKTDTNEFIYQDKYYGRTLTPYTFRDTLQAYLDNGQGCQIQHIPVIIRKLRRLARIVKTMADYRFYASSLLMIYDGDPTSSRKVDVRIIDFANCVTVDEVKYHYKEFTYPPRNKGPDNGYLLGLKTLALCFEWIYKVQGGSPDDLYVEGDDVFCDIFEPANDEILATLLPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4J7</accession>
    <name>A0A367K4J7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 14">Lon protease homolog</fullName>
            <ecNumber evidence="9 14">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_014301</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9 14"/>
    <dbReference type="EMBL" id="PJQL01000311">
        <property type="protein sequence ID" value="RCH97066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4J7"/>
    <dbReference type="STRING" id="86630.A0A367K4J7"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000019">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000382">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="625"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="717"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="760"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH97066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="827" mass="92400" checksum="B684ADE83891DC8F" modified="2018-11-07" version="1">MTLVLPDNLLVIPLENKVLLPSVVLKISMRGKDAVTLTRKHLRASEQRKPTYIACIPLTSTTSVGDEPEIEGFIRPEDKDKLFDYGCAARILRVQRAGLGAFTMFIEGVARFKVKDIVAQDNTLYAKVNYIDQQDLADDDDNIIRFKALVREFLIKMKELRMPENLIQQLTKLLDSVPPPVLADLLVTVIETSFDEKLTMLATSDVKERLEKASEWMTRQLHVLKISEQVHSSVENKLSKKQREFYLRQQASFILEAIKKELGESDGSNGGKEEDDIELLGRRLEEAELPEEAAIVAQRELKRLKKLQPASSEYSVARNYLELLADLPWSKKTQDTIDIKKSKQKLEEDHFGLDHVKKRIIEYLSVIKIKGDLKAPIICFVGPPGVGKTSLGKSIAASMSREFHRISLGGVRDEADIRGHRRTYVGAMPGLIVQGLRKCKVNNPLFLLDEIDKLVHSTHYGDPAAALLEVLDPEQNNSFSDHYLNVPFDLSNVLFIATANSLDTIPEPLLDRMEVITLNGYTFEEKLHIAKSHLLPKQITLHGLQPGQVKMSDEVLLKIAENYTRESGVRSLERMIASVVRAKCVELADLRESNKENEYKPVVTLTNVEEILGMAYYEKEVAEREALPGVVTGLAYSGSGNGGILFVESTKMPGHGDLGLTGSLGDVIKESARIALTWVKAHAYELKIVPTKETNLVENYDIHIHVPGGAIPKDGPSAGVTLVTSLVSLFSGYHVPTTTAMTGEISLRGQVLPVGGIKEKVVSAHRAGIRKIILPLRNRKDVEQDVPEKVKEDIEFIYAKNIWDVLEAALVMSNSEKWHTRVYESHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K748</accession>
    <name>A0A367K748_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Swi SNF matrix associated, actin dependent regulator of chromatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZRANB3</name>
        <name evidence="9" type="ORF">CU097_014949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000232">
        <property type="protein sequence ID" value="RCH97997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K748"/>
    <dbReference type="STRING" id="86630.A0A367K748"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH97997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="677" mass="78637" checksum="C631E69C0046BA6E" modified="2018-11-07" version="1">MPQTCRCGQEAIILEARAPGPNQGRWYWRCAFNACRFFCWDESPHQFIRHPVEAYSSGNTLSGKRWDLGKGYTPATLSTVNNVESDFNPLNRSKTKVVFSLVSDSYITVEYSESPTILPVIKNIDHISWNEQLSKWVIPATLYAYKKAIKALPVNTPNLQIEIEPIPQPIIHTLLVNPIQIKNTYKEETESFGDDDMIDMDVMDRWSKFVESDIYSQLKEFQREGVKRAIERKGRLLIANEKGVGKVDEALAIAAVYRNEWPILVVCPEVLCLTWKYAIQQFFDLDDDEVQHLQEVKANTFNPSTVVKRKKQTTIRRTKKQRQINSQNVENDEEYIVNEEEKEEEEEEVIYKNSKPAQFYVVNHEVATRRRNLLKNVRFKMVICDGTQFVKARGNIHTKAFVTFLGDHPRLIMLSDTASHCLPAELFTGIQAVAPQLVSTFDKFAKRYCDPKQYIFGWIYDGKRNTEELDYILEKIIWHSPKMIDIASQLPRTIYETITAHIKREEKVNTDIDTTLSVMEQTRIYMDMYEKTWQAKKKFIKSYFEYISQSFKESKIAIVLYHNEGLTEFKEYFNSKEIKFADVCNFDTIDQECQNFNTTVRIALIDMKLSGLDPGCLCAADIVICCEAPLQRSKAKQIESYFESEDRIGPLFIKYLMAPNTLDDIQWPIPDNTNDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9A0</accession>
    <name>A0A367K9A0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_010388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000173">
        <property type="protein sequence ID" value="RCH98758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9A0"/>
    <dbReference type="STRING" id="86630.A0A367K9A0"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="47"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="319"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39508" checksum="8B5717FC6F7B62C6" modified="2018-11-07" version="1">MFTITDDIIDHATKILIEESKAITKTAERLKSNADTKEGYYQAIYLMFKALDAGGKIVVTGVGKSGKIGEKIVATMLSTGTSATFLHPVEALHGDLGVVQPNDVVLALSFSGNTEELLILLPSLKHRSIPVIGLGGNPNSKLAKECAAWIDGYVQSEAGGSLPAPTCSTTVALALGDAIALTLAKLCGFTTDGFALNHPGGSLGRRLLLKVSDVCIDPVKVACVTPESSLNIVIMEMTKYPQSSGVIVLAEDEEEEERLSEEMSDSFYPSPPLSAASSVIEDSRPSKIAGIVTHDDIHRILKSKESRNDIFDICAADIMTPNPFVFNEDALASEAYTYMLKHNIPLLPIVSKSNGWTGIVTLKDLQELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K9W5</accession>
    <name>A0A367K9W5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_014350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000159">
        <property type="protein sequence ID" value="RCH98940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K9W5"/>
    <dbReference type="STRING" id="86630.A0A367K9W5"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="324" mass="37566" checksum="7D63633CA95A8409" modified="2018-11-07" version="1">MSTDQSLTWDKNLCEFFKEVGLIETSECLRSELVILSRSHLEKLPDELEKLVTRLIECLERHVQAKEDIIEKPEKEHKDLLIRKRKHSETNEEEEQERIKRMESEQVQIRATAKEVDQRVNTFIQGKRNELDESNRTEFLNRINPSAEDVTCARTDAREINRNIQMKFDIVNNEDGPLARSTITVGNKHTENHTATAADPIERINNMEQHLNIRLDHNAKPPFSIFERVKILENTLMEIEREHPRWAAVHFNQPNRTFPPPPPITYITRPPSEDGYTSTKINTAPPQPRMLKATGRANSSLTRAVVEQLSRQQQLSDAMSDSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KA54</accession>
    <name>A0A367KA54_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CU097_015332</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000145">
        <property type="protein sequence ID" value="RCH99123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KA54"/>
    <dbReference type="STRING" id="86630.A0A367KA54"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="495"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH99123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="734" mass="84809" checksum="856F891382DF8470" modified="2018-11-07" version="1">MDNIDQLVKQVLIVDDSKDPASIRRDLEYTQNVEATLNRIFDGEFLKGIKDNKPNDTLIILDSDEEDTYQVESRNNAAAKDVNADIFDINTVFSDPVVETLNKPSKRKFMDPFGDFDDIPVPSSSKKKPTRISDSTSSFLKKAGQSSKGPFDLFNSQEDKGETDRKKKGKERGSTDNFFLEEELQPVSEDEELFFLKEIDSTITSSIKKSTELIAFNDDEDDILVKKTTERPPKDKSKEDASLLKEIDDEGSFTFAEHEGIGSVNEEKDNTLSREDVSKRSTSTSIFDIEEEEDILHVPTQDEFFDELLSLKKDKVVIDIDSFEEDESNKKRKRRQYDDQHIESNDDRYALLSLEELSSSQDRSALTVKEKKKLEAEERKRKRQEAAEEKKRLKEFKQKEKERQALFEKENRNKTDRTAILKEMILDIHPDFLLTDAGKLLEASLIPKMAEIRPLSEHSELRYTISWKRKCQAEWHSESQTFIPLGNMKIIQEPCVLIYMPVDKLNEHIQSETIFDHMEQAQSSAKDRQILLIIEGLEAYYKKRALIQRRHFQNQVRQSIERPSNDSPSSRKRKSGQENLESLPSRETVEQYLNELQIVKNIMVVPTKNSEDTVVWIENLTIDLGLGRYKTKNLNSTYKGGKSGANEVDTYFKMLQEIQLCTPAIAKSIMKAYPTLQSLHQSYRELDKPSGEMMLADLEVERSAIRARDRNVNRVMSKKIYTIFNSDDPDLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCV4</accession>
    <name>A0A367KCV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron hydrogenase small subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_013230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000085">
        <property type="protein sequence ID" value="RCI00018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCV4"/>
    <dbReference type="STRING" id="86630.A0A367KCV4"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase small subunit" evidence="4">
        <location>
            <begin position="448"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="514" mass="56874" checksum="B950AC899FA3A670" modified="2018-11-07" version="1">MAFSSAIVLTDLNDYIAPSQACIKPVEIQKADKDVQGPTEIKVDKEGAYYEISQDDGQEKKLEKASITLNDCLACSGCVTSAESVLISMQSLEEFTKVLEQNKHQRIIISISPQSRASLAAKYQLTPIQVQYRLVHFFKNILGVHHVFDIAFTQDLSLVETAREFVDRFREYMANGGEAAEKAIYEQQQQEESAGGRPARARGARGQSRKTGESGSMPMLASSCPGWVCYAEKTHGDVLPHISTAKSPQQMMGSLVKNYFAQKLGQAPSQIYHVSVMPCYDKKLEASRPDFEVDGIRDVDCVLTTSEIDQMLQSHHFLEMPEAPIDDMFNKVGTDPQTGQQTLLGVPGSSSGGSLEYVLAAAARELFGLPTIEGRVTVKAGKNADVCEYSLMSDDGRPMLRFASAYGFRNIQNLVRKIKQGKCTYHYVEVMACPGGCANGGGQIVPVDANPKEWLSQVESIYRSVRGVWPEENETIKGIYNEWIGADDIKRKTILHTQYHAVTQSFQNPLATKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFC8</accession>
    <name>A0A367KFC8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000035">
        <property type="protein sequence ID" value="RCI00889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFC8"/>
    <dbReference type="STRING" id="86630.A0A367KFC8"/>
    <dbReference type="OrthoDB" id="2265977at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="308" mass="35439" checksum="6BC8D6BEA30ADDA7" modified="2018-11-07" version="1">MVEVSIVEAQKLTHLFMPEDGATFIVTGTNPVQIIGNLVEISQEESDEDMEDQDYYRYMKLLQPDDFISNRQLSMDDEDESSEDEDYVPEEEESSEDEESIQEDKENQLPSHFQLMTELDEDEDSSDDEDYSPNDGYSDSSEDERITLEELDNSDNELEQANSSTTRVQFVNLPPISDSDDEDDEDDAIVEDYDDNNSDDEELTVTGEPRYANYLSDLLGPDLPDEDEDDDFSSYEQNADAYGTLAFRDPRDNQFLGGFELRHFNLAPNFPGFEKVNLREQEETEEDTYLQVSNKERKRADEEAKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFH3</accession>
    <name>A0A367KFH3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_015876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000030">
        <property type="protein sequence ID" value="RCI00993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFH3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI00993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8549" checksum="B3B47EE4CA1273E8" modified="2018-11-07" version="1">MLTHSTPSLVFFYHHASMRKIGNGGNDYDNPLVLLGSSKEKGEEEVWDIYKVKAMVVAKDDIVVCSIYHHISVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFY4</accession>
    <name>A0A367KFY4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_013855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000026">
        <property type="protein sequence ID" value="RCI01078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFY4"/>
    <dbReference type="OrthoDB" id="2288692at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI01078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="164" mass="18644" checksum="89466E8013A48B0E" modified="2018-11-07" version="1">MFSMPHLRQLRAGFNKSLIYKSWRRSLKEFDTLLLIPEALFTLYSLISDQGFGFGSSSLAAVSSRVLQEFAVVVIINDGALKKEEYRGLLMEISPIIAKKKDVKEWLPLKYMMQNLEECLTKDEQVDVIQFSLDHNVAAVAKELSSSISTVSDSIKKKFISLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGB1</accession>
    <name>A0A367KGB1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositide phosphatase SAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000018">
        <property type="protein sequence ID" value="RCI01263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGB1"/>
    <dbReference type="STRING" id="86630.A0A367KGB1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="213"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="2">
        <location>
            <begin position="620"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI01263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="97724" checksum="0F18CBEE0538A4A7" modified="2018-11-07" version="1">MHKEETIRLYVTTGSFVLVKEEQALEIEFDGLKMTKRDAYEPVNVVQSFEIFGILGFIEGFREKYMVVITAAQLRGYILEHPVYVIEKVACLSFDEHKACHRLSMQRTERQEEDHADPMKRPVKLTQSNSFITKIKKTFAKKKEEEILESITQEPALENDKVIIDNLEIPTTTTTLPLSSSVSSSSAVSTLEDEVDEEDEEEALLDARIVRQIVELFSKSMFIFSNTFDITNSFQRVHKNKANSDIPLWKLVDKRFWWNEYLSRSLIEHDLDEWIIPVMQGTVQIEPCIIDGYNFEFILISRRSKERAGMRYQRRGINEDGQVANFVETEQIVIFKRDEVNHIASFVQTRGSIPLFWSQSPYSLHPVPVLERTEKENSSAFEKHFKTQEELYGRQIVVNLAEVTGREAVIGSEYRKHVEDLGDPNIKYVEFDFHKETRGMKFENISRLSNSLYEDMTKLQYFWTAVDGSEHTYCEQGGVFRTNCMDCLDRTNVVQSAFGRSVLNLQLMRFGITEYPDQGIKYYNSFEKIFNNVWANNGDMISRMYAGTSALKGDFTRTGKRNFTGMMNDASNSLTRMYFNTVKDFWKQATIDFVLGYHKCEIFRYVPQSVKMSAEPGIERRWAKIRSDAIETSSQIVVADDETKITGWTLLSPSEPLKIRPKEFEEKVVILTEKALYVCSYNYDLEKVIQFKRLELDMITSIQVGVYILSSLTPASRNEEQNYGFIINHLTNGELVRWNTGSILNQNLGDLNIGNDKEEEENTEESDTSFIAFKAVRYNVLGELDGKVDSCKKQIENIVQAICTASGHTPDDTDFIIHEPIISLKEAEKTDGLFKKMGHKIKQAIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHE6</accession>
    <name>A0A367KHE6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000001">
        <property type="protein sequence ID" value="RCI01644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHE6"/>
    <dbReference type="STRING" id="86630.A0A367KHE6"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="271" mass="31151" checksum="A2123278EDA05C45" modified="2018-11-07" version="1">MERVLQLEQLPVDILIQIFNYLDQPSRLQICLVSKFMLKTCICIMWYVPKCTTAFALNALMATINNGSNNLYPYSSYMSGLNLSFDQAVHIDVCCNTILSLRTLWIENVESLSPTFLNQIARDIAELGLSRCSKETINSISVILARYKQRSKLEQIDIYDCYMSDQMVHQMVVSTPMLKRFNYCRSGFLSDSSIFAIVEHCQLIESLIMTLPRHIVQANTVTFAALEVLAQLPRLKIFVCRGQVRIATKQNEEWMYKHCPSLIHCDFSFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ILR0</accession>
    <name>A0A367ILR0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA ATPase AAA+ lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005023">
        <property type="protein sequence ID" value="RCH78624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ILR0"/>
    <dbReference type="STRING" id="86630.A0A367ILR0"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055278">
        <property type="entry name" value="CDC48c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48470">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 C ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48470:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 48 C ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="4">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH78624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21848" checksum="4BC818621C88DEA8" modified="2018-11-07" version="1" fragment="single">RETAQREMERRIVAQLLTCMDDLSWEKLNNKPVMIIGATNRPDSLDPALRRAGRFDREISMGVPDEKSRKKILQVLSSKLRLSGEFDFDELAKATPGYVGADLQALITAAGVIAVKRIFKHLRSVGILNSDKKEIDGKPSMENMTTDNDNQEDGNQGEDGASMDIDDTAVEEQPIPTTTVEEFESQTPLEQIRNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IM44</accession>
    <name>A0A367IM44_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004948">
        <property type="protein sequence ID" value="RCH78738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IM44"/>
    <dbReference type="OrthoDB" id="2289328at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="10920" checksum="F1F10C81F8151D9A" modified="2018-11-07" version="1" fragment="single">MKNIQDLNDVPDFVKMEARRLLTLSESPETKPQIIRYNITGDNSNIINILGTVSINSNQQPQSSPKRKSDDDNSDKIPSDFDAILCGGSYKMKHLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INL0</accession>
    <name>A0A367INL0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_000464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004608">
        <property type="protein sequence ID" value="RCH79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INL0"/>
    <dbReference type="STRING" id="86630.A0A367INL0"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="262" mass="29673" checksum="C79BD02C024E4B77" modified="2018-11-07" version="1">MIAALICIHTDEELPTILQPDGINLTAFSNKRATGHFKRRITRFLKYGYLMDMKVLQECVRANVGDLTFEEAYARSKRVLNISVSSSRTQEVPQLLNYLTAPNVLIWSAACCSTASAGLFGSCDLMAKDKNGNIVKWISSNVKWNHWSEASLAESETPLYRLSELFNVNHFIVSQASIYAIPFIAKAQNLHHETLIHKLAYIVASEFKHRLYQLDQLHLLPRAFRGVIEEKMSGNVNVVPDLNFSDLNILFSNPSHQSLAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IP57</accession>
    <name>A0A367IP57_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004495">
        <property type="protein sequence ID" value="RCH79445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IP57"/>
    <dbReference type="OrthoDB" id="2289841at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="94" mass="10290" checksum="FEE9CABB2AE24686" modified="2018-11-07" version="1" fragment="single">MKMRTYLVVIDALLSFKLPPDQLPGTDQLSKSILKTSTAIDIITSNLLDVPKGTYTIAGTEWANGSRSDILYVPYLGIQNSLPPILIEVQSIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQN9</accession>
    <name>A0A367IQN9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_000062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004192">
        <property type="protein sequence ID" value="RCH79939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQN9"/>
    <dbReference type="OrthoDB" id="2448606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="204" mass="23209" checksum="3D5450C14D714E03" modified="2018-11-07" version="1" fragment="single">IPFQLKEREGHSLNYSAAKIEFTIERILSRVILKTWRESLIASEYTNKRPDGIISSHGNKTIGFIEVKPLSDAAVKCKINLDVYRLGVFCKNAIDAHNLKCAMAVQAVGTNITFFLVERHGKIFTMTELHHLRFPTLITELASFIGYFDKLLEVVKIFYSRCVENNTSSDGFTSPSTLKSPLLRSIVNQSANRKRKSHSQYSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IRF2</accession>
    <name>A0A367IRF2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EPL1_1</name>
        <name evidence="9" type="ORF">CU097_000588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004015">
        <property type="protein sequence ID" value="RCH80253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IRF2"/>
    <dbReference type="STRING" id="86630.A0A367IRF2"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH80253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="433" mass="50625" checksum="5664BA264ECBE344" modified="2018-11-07" version="1" fragment="single">VPQIETGVEKEEEEEHDLQAAISAAQAAVTTGVTIEKYIPTPDASRLISDNEYNALYKKKYKESTTLIKFSSTVEDCIGCPYVMDEEDDAFLQSYNKQYPGEPLSEDTFESIMNECESITNQNWPHLYLDPEQTPDFKTFKEHVPDYSKLNSCPSLPVVFEHWRKRRLERRGKSIVPQLKLEETVKNELDPYICFRRRETKPVRKTRRTDQQSLERLRKLRSEMEMARNLLEMVLRREKIRKESLVLEHAVFDKKILLQDYQRKLGIKEDEDLIHLSSKKKRKVSIGGSSGATIKIPLHKLRRDIRIEKSPAQLAIEAELARRKEADFPYEDVTEDPYQPFPLSTPHHFFQSLSNKPSRTRYRKRMGRGGRIFIDRCGYSARYRPTGGKTRPGELQETTYDRFRFDSDNSDTDDEDGNELVVDEMSSLYLKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT86</accession>
    <name>A0A367IT86_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003706">
        <property type="protein sequence ID" value="RCH80849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT86"/>
    <dbReference type="STRING" id="86630.A0A367IT86"/>
    <dbReference type="OrthoDB" id="5564519at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016817635" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="96" mass="9802" checksum="C96A6834D1AF3685" modified="2018-11-07" version="1" fragment="single">MKSAFLTAAAVVAAASQAAASITVVTPWASSTWSAGGHGEISWNATAPENALNCDIQLMNGEAKNANLVAQITNPATPIACSAGKYDMYPLNDFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITP3</accession>
    <name>A0A367ITP3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003598">
        <property type="protein sequence ID" value="RCH81065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITP3"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="27245" checksum="C452503AF4494B82" modified="2018-11-07" version="1">MVNVEYVAQHVAKYILAKISKHVDIDADYQRRITEKAVTSACDLYRVCKGVTLKGSRCSRHVAGDADYCFQHRGMEEESSGSSEEETEDDASASEEESEGESSGESSDEEVPPPKKSKNSTKAKKTKKSKTTVETSPAHSPQQGGTPLVQEFQDEKDRLACAFLEAVRDVSREINRNPDIPEGDKFFYTWLTVDAISAIKHIHNTGEIMHDTVDRISNSLSNGKYELIDLDRLAQQISRNLGMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITS8</accession>
    <name>A0A367ITS8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FUN14 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003597">
        <property type="protein sequence ID" value="RCH81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITS8"/>
    <dbReference type="STRING" id="86630.A0A367ITS8"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23438" checksum="DF5AC156CA53B8FD" modified="2018-11-07" version="1">MLRLSTRVCSSSSNVFKTSSRVSRPIYRAQAIRQYTTPKQPVFNKTFSTPAATFGASKIIPLTAFSIATTPLLVKKPVMCEAVYANDISQPKIITTSKQKPILNKGELTFGTFLGFCTGFLIKKVGKIFAMFVGTGFVFLQYLAQEGYVTIHWDRLEGKYNKTLDVDKDGRVTAKDLRSKWQKFVDLLTNNIQFKSTFLIGLYAGIRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IU63</accession>
    <name>A0A367IU63_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Copper amine oxidase N2-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_002849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003522">
        <property type="protein sequence ID" value="RCH81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IU63"/>
    <dbReference type="STRING" id="86630.A0A367IU63"/>
    <dbReference type="OrthoDB" id="2212155at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="124" mass="13770" checksum="6D16A83FBDDC7A7E" modified="2018-11-07" version="1">MSAVKEMKTVTAATTSSKVHPLDQLSGDEIIQVATIARQAKPEIDFVFNTITLKEPKKEVMLSYLGWDNSRPRVTQVEREALVVALEKKTMKCFEGLVSLSCIDSVIQSNQIHSVSCFNDIRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUD6</accession>
    <name>A0A367IUD6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_001220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003502">
        <property type="protein sequence ID" value="RCH81288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUD6"/>
    <dbReference type="STRING" id="86630.A0A367IUD6"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH81288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="173" mass="19601" checksum="3E3F3479242655E6" modified="2018-11-07" version="1">MSITQQEQPKYINALLIPEDTEEDNKYIQPSSSSSLSIVQPNNSSNNNKKRSLDNTEIKLEESSPTPKKERKPRKAPHELLTDAEKKANHIASEKKRRQNIKLGFDQLIDIVPSLTQGNRSEAFILQKSVDHIRHLISVKNDLKSQIKDLQNLLGESAFDDDVGSPPNLNYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUY6</accession>
    <name>A0A367IUY6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003408">
        <property type="protein sequence ID" value="RCH81494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUY6"/>
    <dbReference type="OrthoDB" id="2279471at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="155" mass="17904" checksum="0C4B29865AF2252A" modified="2018-11-07" version="1" fragment="single">GESAGDSQDASDSPGFEVDLRVVKDTMSRRRKEADKAKVEIARFNPSMIKITNDRTKLLIESKTTLVKLIKEVPEKNKDYCYPWSTDHSKATLFSLKLGANGLYVEVKEGVTVPHNHIARIKEFREVIMLLFKLKARIKELYSIIKRFNEFKRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVT6</accession>
    <name>A0A367IVT6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003268">
        <property type="protein sequence ID" value="RCH81813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVT6"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH81813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="97" mass="11308" checksum="F4E17BF09366F28A" modified="2018-11-07" version="1" fragment="single">MLRARLPLRFTCRNRNCNPYLFKHLERSQFNAFPTISMLNSQFRSMNIQTNEQAATDKQGTAPSATAAFRDLLGIQRQPEEDLKNTFYQRELPKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWP6</accession>
    <name>A0A367IWP6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003150">
        <property type="protein sequence ID" value="RCH82104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWP6"/>
    <dbReference type="OrthoDB" id="10319608at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="319" mass="35980" checksum="A1094D1D2506D727" modified="2018-11-07" version="1">MKIFDIEEFDNINNATLDGSTSYFSSTSNQLVQTSGLKTTTTGSFSGFKSGINVTPMIKLRGISHLTEEERRERYRTRLTDKLIINPMIKLPGPASRKSYLTPLGSSSFADQGQQRITSEGSSACSKIDQTEQKVTFSTFGDPFIMQIRKDESSSTSDTTSKISVSNTEFQKLLNTAKAIIACFKSVFKETHQKTIDRLSGSIMPLVLFKETYAMRLRDKIESLVIQLENDEASSELNKSEQNNFNEKLKDFISKTEEYSLATRSLEDAVSTLVDECEHLVQGLREDLSIKKRARLEWDDINSQLSEQGNQVWKKQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWY5</accession>
    <name>A0A367IWY5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003193">
        <property type="protein sequence ID" value="RCH81991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWY5"/>
    <dbReference type="STRING" id="86630.A0A367IWY5"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH81991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="122" mass="13948" checksum="CF75BC8F4B583FD4" modified="2018-11-07" version="1">MGLTYRTYLEGSSTIYGCLKCKTHLSTSDAIISRQFHGQHGQAYLFESVVNVKYGKAEDRDMTTGLHRVKDIYCIQCATLLGWTYVKAYSSENKYKEGKFILEKKLLTDLSARIYIESRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXI8</accession>
    <name>A0A367IXI8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CU097_003811</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003033">
        <property type="protein sequence ID" value="RCH82382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXI8"/>
    <dbReference type="STRING" id="86630.A0A367IXI8"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="17">
        <location>
            <begin position="146"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="352"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCH82382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="489" mass="56846" checksum="C45EA07DCDE9A9A8" modified="2018-11-07" version="1">MFRTTIRTRLVQSYQPFMVRQRFLTQQRVFLQRSEKEMSAPEKKKTLMQKIKEEAVHYWHGAKLLGLEIKISSRLTYKMLQGTKLTRRENRQLRRTTSDILRLVPFAVFIIVPFMELLLPVALKLFPNMLPSTFEDKKRAEEKKKKLLKVRLDMARFLQETIAETGSIAGTDPEAAKEFANFFRKVRMTGEQASTDDLLNLASKFEDELTLDNLSRPQLVSICRYMNINAFGTDNFLRFQIRNRMRQIKNDDVEIKREGIENLTLQELSAACAARGIRTIGTSPGRMRDELSQWLELHLEHKVPSTLLILSRAFTFTDPRVTPEDALRATFQSLPDNLVNEAELQVLETVGASTYKQKLDVLEQQEELIEDESEQEEKEEKARLQEQDISQLKELPSIDEVPSNDEDLQAALAKLKTKVEYLEQRAQLNEIMFHHEDYKELIEELKAAKHGETNKSTERLSQRLEKMLTAIDKELDALEKNDNDDNKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IY97</accession>
    <name>A0A367IY97_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ACSL5_1</name>
        <name evidence="4" type="ORF">CU097_004163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002938">
        <property type="protein sequence ID" value="RCH82660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IY97"/>
    <dbReference type="STRING" id="86630.A0A367IY97"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH82660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="546" mass="61262" checksum="AB16BDE360CACD9A" modified="2018-11-07" version="1">MTFELDTLSYTLLASIVGAAALLSARNSKSSDIHPLLLNTQSDVSRLRHPGESAIYRSRMYPMNSPLCSTFERSIRTLADFYKEGGFKKHGNADFLEQEGGYASYETIRSKVERVYQGLRSVAKLVPQSKDENSFVGIYANNSYHTVLTEIACHMHGLVTVPILASYLSHILEKTKLRVLVTVESHLREVLIHVSDIPTLKHIVVVGNISEADKDKAVKAGIELVTFNELEQRGADKSYDDVQVVPNDIASIYFSPANEKSKHGVVLTHKNLLSSISSYLSIVPPAQRFTSKDRLMVNLSIDNVLRYVLTAVISFTGGSIVFGSQSADSNEVDILSYLSMIPQHKPTIFVSNSWLLGQLRHLIESRYGKSFLYKRGYDAKKEYLEESRLVNDCKYDMLVFRNIRQTMFGGNLRLIYIDNDDNSDPTLATFLRIVLSTQVIQTFNLPETSSSITASMFFDYNALPEARGAPLPCNEIKLVDQPERALTAEDKPNPRGEIWVRGNNVFAEYYKDEQATSDVIDSDGWFMTGYLGEMLPNGTLKVLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IZH4</accession>
    <name>A0A367IZH4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_004304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002866">
        <property type="protein sequence ID" value="RCH82861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IZH4"/>
    <dbReference type="OrthoDB" id="2284738at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18902" checksum="449BA75977C360BC" modified="2018-11-07" version="1">MRRSYGWCEVRTPCKIKVETRESNVSILGAIFKDGQITLSRKEIITTPAAGKRQRADDTPAVKRKEFIEQVLTTIDVAGMNYNYVVLENASIHKANLVRDWFSMIINAISLITDRIEKSNTYHDQQDMADLRMSSLQSYIEQQLVAFNSKSSAIHSFKLKSPLSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J006</accession>
    <name>A0A367J006_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002717">
        <property type="protein sequence ID" value="RCH83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J006"/>
    <dbReference type="STRING" id="86630.A0A367J006"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20429" checksum="4795BBC015D06E20" modified="2018-11-07" version="1" fragment="single">MLQESDISPQQLWEAFKHKRTSIDLYTQDATVLFVPTLVGARGNAEIRKFFLHPHFSDKSNPVKETVFNTLMSNDRLMEESIWSVHFHTGECNWLVPGIEARYLLNATVKFPVSTSVVFVNNKIQSIRYHWDQASILKQLKVITEKLQWPVIGEQQVDALYTINTVPLKHLHEQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J054</accession>
    <name>A0A367J054_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002742">
        <property type="protein sequence ID" value="RCH83199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J054"/>
    <dbReference type="STRING" id="86630.A0A367J054"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="537" mass="62224" checksum="BE6EE8560691B6EF" modified="2018-11-07" version="1" fragment="single">MSYIQLQRTRLRMMNKTSSVSSSSDLIVPSIEESLQDWLSRDNSCTYLLDICRCCNKSNCDNLQTLILGIQKLEEDARLAAEIGQSLLNKHEQYVIESNEAISGLESQVQESQEKIHELEQLLIQSDTVKYDLEQEKNKLNWEWQKTQKMLDDTLLDVESYHQRINQLTSELDSKTREIDKLKKLMAHQADAREDHLRFALEDMKQELANSKKAELCLESKYKKLKEKYDQLCEEKKQLTNDQEPSERLHKDPNKDLLSESRTEAVGLIAKIERDYIDDDDTTMTDQQEIWPQNNITCDTVSSSAVVHHHYHYHMRNNKGKPSSLSSNQTPCQPTENSTETMSPYRHLHRQLCVLLERLQQTDTRALNRKLRRAFDIFDLSSMSNSIIENILTAEINELAHVFPCHSKEQDFSLLVKVTQDMLKEIGQLRTNINDLQVEYVKKVEEIDNRLEQELIKRNVFQKSTASSNNIIQQHEIIIHSPAIIIPSPSPNKMEEYRNGPPSSYPIRSSLPSAKRRNNYALHASQSAILPVQKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J055</accession>
    <name>A0A367J055_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ORC3_1</name>
        <name evidence="14" type="ORF">CU097_000021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002701">
        <property type="protein sequence ID" value="RCH83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J055"/>
    <dbReference type="STRING" id="86630.A0A367J055"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="13">
        <location>
            <begin position="423"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="680"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH83324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="756" mass="88505" checksum="9250F1A58C714109" modified="2018-11-07" version="1">MSNTTAFVRDHFDSISEGCFLVMPNKKRKLNEDKLTKKKSKIKEIKLRHRTETDSSGISHNGFQQLFNGREPEDTLLYRQRAFYRAWNKINTIINDTLVDMNQTAYSQIRQFVDKAHDVKEELISLPFHEIPTALVFAGINTPDHAKQFEHIALDLKQPPSETNGRQKRNFVSLLQAKDCPTLKHMMKLMIERTLENTEDKTDNQLEKEEEEEEEDDDDIIRTVQPSTAPSYQFGRILAKESKALSYDMQLLEGWYKHRSKYEKHKPNLVVILQDFEAFEPNVLQDFLSICSKYQTQLPIVCIIGVATSTEFVHQSLTKLSINMLRIERFKLENSDVWFNKVIEKLFLESIDTLRFGPRPYKFLLDHFYLYDFSITKASASIKYAYMHHFYGNPLSIFLPLLKFDKQKMRERLKEWRSKDMLNTHHVVHIRMLSSFRAYIEKLATTKPRKALRLLEDDEELLIQEVPELLANIKQYYVEFVLGIDLVQVLQSQFSSFSYVKKSRRMILLEALEAKEGYATQSELIQKLISLLRKMDADQIESLLKELQNLYQRKEYSRVSNEALKKLNEWHERLMRLMDLDDDAAAKADKKAKKIEGMVMTNIEDKHGRHTATAQKAQNESIEFIRRLGTESTKIAIDIADWINDVLGHYLEPFTKKPLYEITYYTNVRLLEKSFASQPRATVQTALTQPSHYLNCTCCGDSKERHLAPSEPDACVLYKLYLECGRMINLYDWFVAFSSVIEKEKRDKPLEENEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0P9</accession>
    <name>A0A367J0P9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002675">
        <property type="protein sequence ID" value="RCH83399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0P9"/>
    <dbReference type="STRING" id="86630.A0A367J0P9"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="179"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="386" mass="44312" checksum="3E3F9085DEA550DE" modified="2018-11-07" version="1">MTNYIEIFTTRGTKGIDVTVTIHANIQKELKLALNEFVLDTKQSHHLGVTSLVATVPSMPFINSRVAVHICFIEHGTIVDTRCIASFIYEQDTMNTSLIRAHSLKGYQPNFDLSGYVRDTTYPTLRPQPASATQSTSSMSLSYNDFFSDSAHSYITKAFSYTDSISVAGYQSCHDLNHQIDFKIIGDTNSVMYSWTAEERVKSRRLVQFWRQKEQTDITCAFKPVLTTQLDQPMTTIVSCIYWMERNDFFITSVDLIALIESLLGISFNVDEKNRVRRNLEGFRPVTIGKSKPESANFFKLIMSYPDPKPRNIERDLKVFSWRTLPFALQKIIAKYSTHPLTSKRLRHEQHNAFRLSGNIDLSKRGHEHIKGEHDEDDKRLKTSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0Q0</accession>
    <name>A0A367J0Q0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002711">
        <property type="protein sequence ID" value="RCH83291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0Q0"/>
    <dbReference type="OrthoDB" id="2289803at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="272" mass="31122" checksum="5BDE607C56C28A70" modified="2018-11-07" version="1" fragment="single">MSCGQDNSLSDLVQQLPLERDRKRYSKLIEMSESLQSRLDCLYSQSTIPCPRDRHLRKQYSLASFGSDITARTDDIEGAKDTSNANDTPYFYFMDDDSWPRSSIQEGHVYRKLDRATSMQFTPKSTYFDRYPSSDKVLLHVRNKSDRIRPCTVHVKPSTLRRSRQIHQPLSQEQIKTESDSHGSHLCHNEKASFETLAKEDTSLVDKVTNNDSCEPISSVDTELTKREHDMTAPSVLTTKHNESTDLPTPPSTPFGQDTSFPDLPPLRHIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1D0</accession>
    <name>A0A367J1D0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002576">
        <property type="protein sequence ID" value="RCH83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1D0"/>
    <dbReference type="OrthoDB" id="5563272at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="67" mass="7756" checksum="871FA908A3537FDC" modified="2018-11-07" version="1">MFQKIVNFWFSSFITERLLASPLFNRMAAKTHHHVSTITEKGAKTGGEFVKAFRENLEKEARNSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J465</accession>
    <name>A0A367J465_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_005418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01002276">
        <property type="protein sequence ID" value="RCH84754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J465"/>
    <dbReference type="STRING" id="86630.A0A367J465"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="108"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH84754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="447" mass="51163" checksum="6514F79A12AF4053" modified="2018-11-07" version="1">MGFFQAIFHGKKGDLNKQLEHDVITPTQSHDYSRFQLFDDGTHAHHLSLPPPNRIIHGLMGIAHKSLRLTTQWADRKPTIDEIKKERAALDQCLHRQSDDRSLSDKWGICQETIGKGTSGVVKIAHKLDDSGEHLYAVKELRKKTNESSKDYIKRLTSEYLISSTVQHINVIQTYDLLPLNDISPIFCQVMEFSGGGDLFDILVDSPDGLEAPEANCFFKQLMRGVDYLHDIGIAHRDLKPENLLLTVTGCLKISDFGSAVCFRGTTIDSDGEEKKDDCEKIHMVRGLVGSEPYIAPEEFTQSIYDARAVDVWSCGIIYLALRKATHPWQLAKSGEDEAYDKYLKFRQLLDEERENARKESAIRKQNMSEEEKEQERLRREQDLLKAKETIRRKAKEAKIDTLEGLDIQAKKIIYRMLDPQPKKRITAIDVLNSDWCEKIYCCQPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J545</accession>
    <name>A0A367J545_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002193">
        <property type="protein sequence ID" value="RCH85062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J545"/>
    <dbReference type="OrthoDB" id="2263584at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="104" mass="11801" checksum="6E73680BB87391C7" modified="2018-11-07" version="1" fragment="single">MPKKKSTIRSDIALSIDQQKLFKPSQPKKTLRHRKEENASEVLQEMIANSDYDNALKLFKALLESSRFSISSLWETGVELIGTVEPTKLTDYLHGVYICSQGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5J5</accession>
    <name>A0A367J5J5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muskelin 1, intracellular mediator containing kelch motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MKLN1_3</name>
        <name evidence="4" type="ORF">CU097_002645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002211">
        <property type="protein sequence ID" value="RCH84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5J5"/>
    <dbReference type="STRING" id="86630.A0A367J5J5"/>
    <dbReference type="OrthoDB" id="10052615at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Muskelin N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="772" mass="89198" checksum="63C52DFDE4EC101F" modified="2018-11-07" version="1">MKKERDLQSIIKEASYEPIQYSIHDYSSHSGTYYPQNITVNNPTEQSSRWSSGSHDQSQYITLKLEKPVIACEILFGKFHRSHVCNLKEFKIFGGMDLDNLNELLHDGLTNDNEAEVFPLRYTYDDLVFPVQYIKISPIATFGRSFNYSIWYVEIRGIKKNSILSQVFDAYMKYKELETIKLCLKHFRQKNMMDLYHLLKEKTGVEFEHPLISNLHQALVIDGNFDEAERIIHNAEASSIFDHYVQTAKYSLLWQEIYASNSDGDTPCPRGGHQMCIDVDSGKIYLFGGWDGSKDLSDFWCYNIEKQRWKLLSSDTLADGGPSARSCHQICFDPTKKSIFVLGRYIEPSTNTTIADLTGNTYGSDFYQYFIELDQWIKISDNTQIDGGPPLLYDLQMCVDPVDRILYVSGGRIAAPGSTSYAYGGLYAYDMISSSWETLRHDEITQGARSPHSPDEAYLARWAPGNRSPLPIQTIKGRAGHSMAIHAEKRGIYIFSGQRERSHLSDLYYYSIDEKKINNAVENFFKGDGSDIGYTQRATIDEDMKELYVFTAYVNGMPSNTVKNLIWVYSIEKNHWEKLYENESQDPCSSKCTKGIEPTPRFAHQVVYNSKTKIHYIFGGNPGDHRNEHRRLNDFWELKLTKPTSTQIVRKCIYLIRSRKLYEMCDKKLHINGGRLELNLNMRKDTMSALNYLRDYILPLVDHENREEVAQFKQLCAHLCIPTYGKNDVNREMQTEDFIFASRTKVFQHLLEYFPRHMKEPDGSVMDSVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5L0</accession>
    <name>A0A367J5L0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002144">
        <property type="protein sequence ID" value="RCH85254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5L0"/>
    <dbReference type="STRING" id="86630.A0A367J5L0"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="316" mass="36089" checksum="8AA80CFE6BFC9F9B" modified="2018-11-07" version="1">MVVQSIPIVDFAKFEENPNKVAQQVFDACKSIGFFYIINHNIPQGDIDKAFELSKEFFNLPQEERHKYLIGKDNHGYSELYSERLDPEHQKQGDHKEGFNFRNFINGEPFAPLPSVFDKEKDFLCHFSQMCYKTALQILLAFGIALEIPEDKGGKDFFVKAHSYENSGDILRFLKYPRGGETDVKDPVRAGAHSDYGSITLLFQKDIPGLEVQASRTEWISAPLIEGAILVNVGDQMELWTNGLFKSTLHRVVFLPEHKHLDRYSMPFFVHPDDNIPLSPVPSKHVDQSSKTDGHILTAGEHLRNRLDATYTYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5U6</accession>
    <name>A0A367J5U6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_008650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002136">
        <property type="protein sequence ID" value="RCH85290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5U6"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="66" mass="7400" checksum="92BE5228936FB89D" modified="2018-11-07" version="1">MDIGELENPYSYDKCGSKHSQTGTSGPLQIGDYDEKQNGCSKQQAKATEEHCDNKLREEPKEVPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J5U8</accession>
    <name>A0A367J5U8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002153">
        <property type="protein sequence ID" value="RCH85219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J5U8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH85219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="90" mass="10517" checksum="AB55D0506BE6C33F" modified="2018-11-07" version="1">MLHMLLQRQRQWILTYLCFDRKLEVVEALGNVHIHEYESVISGWWWKFEGINRTKSHGVGGDIRICECICVRVNKGIRDAVGRSTGALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6C7</accession>
    <name>A0A367J6C7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002091">
        <property type="protein sequence ID" value="RCH85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6C7"/>
    <dbReference type="STRING" id="86630.A0A367J6C7"/>
    <dbReference type="OrthoDB" id="10358330at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="18580" checksum="70D10F3375E02A9A" modified="2018-11-07" version="1" fragment="single">SLKTHLSKDYIQIDPTLLERLVRAGIMCPAFTERQKMTLLQTFRLEKCPVDIVSFMYPIHSDDIFSFHQINVENVLGDDPASISSLIRDIQQQCQVEDRPSKPTENKMVSHGIPLLLHPLESKGSPWTSSSSSTSSLPLSNSKSDIWKASSPVLESNKLTSSKVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J778</accession>
    <name>A0A367J778_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRE3</name>
        <name evidence="11" type="ORF">CU097_005339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002014">
        <property type="protein sequence ID" value="RCH85788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J778"/>
    <dbReference type="STRING" id="86630.A0A367J778"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH85788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="211" mass="22813" checksum="1CE8C17F04ED9F6A" modified="2018-11-07" version="1">MSLKKGEVNLGTSIMAVAYKDGVILGADSRTTTGAYIANRVTDKLTKVHDKIYCCRSGSAADTQAVADIVHYYLQMYSVSEDQAPSVRTAAALFQELCYQNKDNLMAGIIVAGWDDKDGPSVYNIPLGGSLHKAPFAIGGSGSTYIYGYCDAKYKDNMTREECEEFVKNSLALAMSRDGSSGGVIRMAVITKDGVERLFVPGNELPVHWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J802</accession>
    <name>A0A367J802_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KES1_2</name>
        <name evidence="4" type="ORF">CU097_003574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001952">
        <property type="protein sequence ID" value="RCH86046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J802"/>
    <dbReference type="STRING" id="86630.A0A367J802"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH86046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="412" mass="47207" checksum="E2E70ACA7B6CAA49" modified="2018-11-07" version="1">MAIGFGSKDKKNNSKALDEEPPSENDVDKLSVKNLEEKSQFKEFKEFLKVVISFTGDLSSLTCPAFFLNGLSLLEYGTYWGDHPALFQAVSQAQSPEDRMLSICRWFISTLWGSYASRCTGGKFEKKPYNPILGEQFFCTMGDAKCICEQVCHHPPISAFYLEDEKAGVSLNGHTGQKSKFKGTSIRVEQVGRAVLYLKQYDEQYMLDFPDILIRGVLTGGAFIELGGVCTIVGSNNTKATIEFVPKPWFGGEYNHIKGWIYHDDKVQYQLSGRWSHQSFYSKGKDSKKELLFDAEAEPMAKRVTPPIEEQSEIESHRVWGPVTEALKQKNYKVANKEKTRIEEWQRGVRKEREEKKEVWEPKLFKFEKDDDASNGTDYQKKNHALRTKMDLHHHLDSGAWTYVHSLHTRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8M7</accession>
    <name>A0A367J8M7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001895">
        <property type="protein sequence ID" value="RCH86314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8M7"/>
    <dbReference type="OrthoDB" id="2289268at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="290" mass="33043" checksum="DDBF32B7F7B63F6A" modified="2018-11-07" version="1" fragment="single">KRRRPNEQREDELMEALQQQFEETLSLRIQTCLEKGDDLEQLKESCLNEKRLPRGVVTGSEKRINAKAAELENYDELTEVVRLRSESLASTVSMAKPSEETELMRTCSASLASLIRKDLPEGIRTAFLDTIERTLISATDYVVEYSMQRAAKDVRMPHSPTPATDDEDEAEMRLEIAVDTNRITDEVATVVDEVTSDSTDTTRRRLKILGGVIKSMLFEKRDKVINEGEVSNALPGSEQKELQVCVRTINFLKPYIPEKNNYYTMSHQLPFFLMANDILHATGYSKFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J900</accession>
    <name>A0A367J900_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001914">
        <property type="protein sequence ID" value="RCH86221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J900"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="94" mass="10582" checksum="827E133231F8EFDF" modified="2018-11-07" version="1" fragment="single">MSHFKGEKLEDKQKKELSSLKLNSIEPSVPENCKLNPKDTKNDFQESLKKLTSTKTKVSFVSFDGSNNHLCISTTKSAKRALFVSYLNAKAMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9T3</accession>
    <name>A0A367J9T3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MIS3</name>
        <name evidence="14" type="ORF">CU097_009470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001809">
        <property type="protein sequence ID" value="RCH86714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9T3"/>
    <dbReference type="STRING" id="86630.A0A367J9T3"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="131"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH86714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="291" mass="34126" checksum="791723126CC48731" modified="2018-11-07" version="1">MAETDQPEQQKNNKRFRKDKPWDTDDIDHWKIEEYKPEYTSQPFTEESSFATLFPKYREAYLKECWPLVTKALEKWGIACVLDLVEGSMTVKTTRKSWDPYSIIKARDLIKLLARSVPFPQAIKIMEDGIACDIIKIGNITRNKERFVKRRQRLIGPNGSTLKAIELLTKCYMMVQGNTVAAMGPYKGLKDLRRIVIDCMKNIHPIYHIKELMIKRELAKDPKLANESWDRFLPKFKKKNVKSKKKVIEKPKKEYTPFPPAPVKSKIDLQLESGEYFLNKEKNSKKRKLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9U2</accession>
    <name>A0A367J9U2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001815">
        <property type="protein sequence ID" value="RCH86680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9U2"/>
    <dbReference type="STRING" id="86630.A0A367J9U2"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="410" mass="46539" checksum="CA7AA3EDD3647F46" modified="2018-11-07" version="1">MPTVSLYNNDTPISHRLTNLIRQSSLPNLSYRANKNTKTYGYSEDIQRILSGAHTLGIEDLKYILYTNKSSLTSSLSDQPGYSRRKTSEVDDYYHQYKRKPSSGSVGTTDSGIDISSIKKAGHTKSILPKDESEIDRMVSQHYILRTAFDSDFSAPVSSLINHKKKVKKTPVVVLDVGCGAGTWTMEMAVQFPHATFIGIEKAPLFPRDIKPRNCNFMIFDTSDNNYRLPFEDNSVDYIFQRDANWELTGSAWVPLVQEFYRILKPGGWIELVEQDIETQSSSSDEGFLIDKIIDILSSHQHDPFISKRLSSILAVVGFRSIKSDFQSIPLGWGYSKCSRNKAQSICSEYARASAMQHLLLLKSLRPWFTQDGQKSKSKFDSCINKLLADWHQARSYVNWHKSIGQKPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JA91</accession>
    <name>A0A367JA91_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001802">
        <property type="protein sequence ID" value="RCH86749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JA91"/>
    <dbReference type="STRING" id="86630.A0A367JA91"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51494" checksum="8CFF91B64695945B" modified="2018-11-07" version="1" fragment="single">MSKLFGNSSSNGYKPLLSPGEKPYRKQKTRLLLTASALALFGTSCVYLSRHLPTGVMLSSYAEINQQSLWNNDNGKVVSPGISFDSFEYGLSKCQFNIERSRVSTNTTRPRHRNPRVAPEAERVLIRNGHIWLKDHYLEGGDVYLENGLIAAVGKNLQVPSDTRIVNAGGRVVTPGIIDMHSHMTVDALDGLSASDDTNEMTDPTTPYVRVIDALNPTDPGIKIVASGGITTSLILPGSGNLMGGEAAVIKLRPVSTLSAQDMLVTSGVSDEDQEVIWRYMKMACGENPKTFYGSSNRMPSTRLGENYLFRRKFEEAQRLKRKQDDWCDAAKRIKKMKDDDDKQDLIRLSESYPEDLSLDSLVALLRHQVNLNVHCYLPQDFEAMIHHSLEFDFEIAAFHHALSAWQVPDIIKRAKTNITVATFGDMWGYKAEALNQNVHAPKILDKAGIPVAFKSDHPVMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAX8</accession>
    <name>A0A367JAX8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANAPC4</name>
        <name evidence="8" type="ORF">CU097_000630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001740">
        <property type="protein sequence ID" value="RCH87045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAX8"/>
    <dbReference type="STRING" id="86630.A0A367JAX8"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="242"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="406" mass="45937" checksum="BDC865AA9C2C0599" modified="2018-11-07" version="1" fragment="single">MSNNDFTHFAKRILTDPAKFISWCPVSDLLLIVSPDNALSLYRVAIKQLTLLWSSETAFDSTITSVTWRPDGKELAIGCENGVVYKVDTRYESLCISQCWPPEKSNRPLSAIRSLFWTQYEPETKDEIIEGFDPTAFDPELSLPMLSRLPLIEPTIKVNIRHKKKTLPERPFDNAETQTILFVGTDNGDMIVILNGVYQIGTFNTSQEKTAKDISILDIAATNTISFIKVFGCTKSTNEHCLLTIDTSFLESKKEEISKVAEIKTRLDYLFQYATHVIETLKDHHSSYTKLTKNVVVSASDAIISNNGELQKPIPEVEFIAILATGNLSQAIRELITDELTPQFIKQWETTNNHGYQSSLRIICEHALPVFERILLQLSDSLGHSLWKERYEPFLDVASVESCIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JBC8</accession>
    <name>A0A367JBC8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001694">
        <property type="protein sequence ID" value="RCH87262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JBC8"/>
    <dbReference type="STRING" id="86630.A0A367JBC8"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="265"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="392"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="750"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH87262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114652" checksum="ADE031ABCB11E5D0" modified="2018-11-07" version="1">MSLTYGQDEVSHLRSQNDQLWKIIEKQRVMIQNLQKENARLSADRDGLLDKVNSLEKEMIRKQRVTSLLISPQTLKEIAEADDASVSTPSETSPVELPPLSPMPPPRSPYRPLKERVDAAFLQNEPEDIIHGRSSPGSPAPGPHSPTQVIRKDSAPLPSNNKIVVPTPSKSSSSLDRRQHQRESMMPPARAALEHDPTMRAASPPPATPSIRTTRSKRESAVLHRANSDIQQSMKNMSTPNLPTYEKPDDEPKQDNASFMGNMANIHIKLVGSNIKPNDKGKEVISFIIAIGSLGHQDEFEEKWRVEKLYSDFLTLDSKLKAQRSNRSATARIGKLPDKALFSNNAPSKVDQRKIALEQYLQHIVALPLENTSHLCEFLSTNIVDTVKHQIPGHKEGYLTKRGKNFGGWKTRYFVLNDNVLEYYESKEGNQLGSIRLTNAQIGRQMPGTTPAAEEYNNIYRHAFLIVEQRKTGSSHFVRHILCANSDDDRDEWVQALTQNIQLEDNFKPHKKKSSEKPRKLSKGEIRTVSAQPMSQVKLDNAADMEKFNAVVPAVNVHPEENGGLNIPNQPTPSISSESSDSLPTTWGSMTDMSRPSLDHSRTLHAPRPPIVRRSSMGNLITEGKKQEHHSSRPQRAASPTIITTVASDDADNEKKARNKAHRMTFWGKKMFSSSSNSSADQQQLLRSSSSTTTNNGEPDMKLSQSNSSSTSNSSSGFRGFLSRSSHEQAERQKSKQQEEAKSAKQVFGVPLDVAVRISRINEGYELPAIVYRCIEYLDAMNAVMEEGLYRLSGSNSTMKALKERFNQEGDVNLLASKNEYDVHVVAGLLKMWLRELPTSVLTREHRTEFLHVIDLLDRKDRVNELGRLVSLLPLSNYTLLRALTAHLIRVVQHSDVNKMTMRNVSIVFSPTLGIPPTIFNLFMSEFEYIFWTTENGDAAPRMIEDEEEETKKPAPALSRKTTLRLVREEHGRSNRNSVNYMDGAPNAIVDLEKNMDGPPVLDEDEEVDDLTIYDTSDQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCF8</accession>
    <name>A0A367JCF8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001620">
        <property type="protein sequence ID" value="RCH87623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCF8"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="108" mass="11924" checksum="B96D2509F2AACD53" modified="2018-11-07" version="1">MHSSLASNVPIRDSDTETSVSTIKNIYDQVLDSSAQLSSDMVGHLGLIDFSSSRLRNELDEEELNEITQIGVLPPISITTHVQELIKDIKNIRPASACIREILHKIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCK7</accession>
    <name>A0A367JCK7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_004334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001621">
        <property type="protein sequence ID" value="RCH87615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCK7"/>
    <dbReference type="STRING" id="86630.A0A367JCK7"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="666"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="799"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH87615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="937" mass="105842" checksum="339806B34542D073" modified="2018-11-07" version="1">MVKAYLRYEPLATFGVIASTQSNIVYDHTGKVAITPALEEVILWDLKKGTEIARWKEPGNKSEVTSIAKSPNNKDYAVGYNDGSIRLWNISSSTSTVTLSGHRAAVTALTFDHDGTRLASGSKDTDLIIWDIISESGLYRLKGHKDQITCLTFLTSKGTDAEKAVGTSTEGYLLSSSKDTLIKLWDLSSQYCRETLVGHRSEVWTFAVSKDQKVIISGGAEPQLKAWKIDWNILGLSLEELGEQANNKDEKDATAAASLQKAINPYGNIPRQSRDRLVTIKFHPSGKFVGVQANEKSVEIYRVRDHEYIRKKIQRRKKRAREKGKDDSQVSEEITPEDEFASEYLIRTPAKVRSFDFSPATNVEKAGQLQIVVSLSNNALEAYTIPIAEKKSEESNEPSKLYSLDVPGHRSDIRTLTLSSDDELLASASNNLLKVWNLKTRTCIRTMECGFALCSAFLPGNKHILVGTKTGELELYDIGSSAMIESVKAHDGAVYSLQVRPDKRGFVTGSADKDVKFWDFDMVQDKNSSVKRLTFIHMRTLKMSDEVLCVRYSPNQNLIAVSLLDSTVKVFYHDTLKFFLSLYGHKLPVLSMDISSDNTLIATCSADKNVKLWGLDFGDCHKSIFAHQESIMSVQFVWGTHYFFTVSKDKTVKYWDGDKFENIMKLEGHHGEVWALVVAKHGSLVVTGSHDRSIRIWEKTDEQLFLEEEHERELEEMYENTLVSQMEKANVNGDDMEIDSAGKQTMETLKAGERLMEAMDIGDEEKNGWLAYEAGKAKGLDVPPPKRHPLLLAMGDIEPDRYVLNVLQKIKANELEEALLVLPFSKVMSLFSYIESWAKKNWNIILVSRVLFYIVKAHHNQIVANRMMRPMLDSIRFHLRTQLQRQKDIMGYNRAALTYLQQDWKSRNTAEFIDETTAANGKLGDEDKKRKFVKLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JCR2</accession>
    <name>A0A367JCR2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_009143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001615">
        <property type="protein sequence ID" value="RCH87649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JCR2"/>
    <dbReference type="STRING" id="86630.A0A367JCR2"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH87649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="19085" checksum="FF4F5F5E8F3D94D0" modified="2018-11-07" version="1">MITYSIIVPILPFTIDAIERGRSPNNPGYDPYHSELHNPGDVSKQSGALLALFSVGLIAGSLGFGYLGDRLKHRQGLMLVGILGLIGSTLLFMFSEYYWELLIARFLQGISDACVWTLGMCLISDTFPIEELGTQMGRVMMFHSVGMVAGAPIGGTFLSKQRHDSSTTKPRTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDJ0</accession>
    <name>A0A367JDJ0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001551">
        <property type="protein sequence ID" value="RCH87994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDJ0"/>
    <dbReference type="STRING" id="86630.A0A367JDJ0"/>
    <dbReference type="OrthoDB" id="2239391at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH87994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="217" mass="24690" checksum="254A7A8C77D801A2" modified="2018-11-07" version="1">MENVQYQPLDTIPDAAHRMKPSQTKQDMALKRLQYLISGIFRPLDILGHEISLDNENANIQRYLTILADCRTLLLNLSSQVNDMRNTLGFQTINPTFKSTAAPTQKFYDASCRFSSSPSNSPDTLFLYSYAPLKLLSVLQFNVGSAKLLEYPQQNHVFLSDDVVTMGNWSSSAVFENHYCREHLSQFDFSNTLIDIDDASDEDDDQFFDAEDNMTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDJ9</accession>
    <name>A0A367JDJ9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BSDC1</name>
        <name evidence="3" type="ORF">CU097_001114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001538">
        <property type="protein sequence ID" value="RCH88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDJ9"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="201" mass="24056" checksum="E2820443390CF97C" modified="2018-11-07" version="1" fragment="single">PEEEQQEQQQQQQANRRIYATRKETLIAKMQANPDTYLKDPENEEETKVLKTFNDTFKIDEYTEEIAQLLNDNPELRDMMNTLVPMQVSYPLFWQRYFYQAWKIDQDEQKRQLIVQSVKEEDENDFKWDSDDEEMTIKDNVKRSSEDTDFSQISNPSSTPQLQSTEDEWVKTETQKKETIKSKNDNNSNNNNDDDDDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JDT9</accession>
    <name>A0A367JDT9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_005617</name>
        <name evidence="10" type="ORF">CU097_009185</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001571">
        <property type="protein sequence ID" value="RCH87891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01001570">
        <property type="protein sequence ID" value="RCH87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JDT9"/>
    <dbReference type="STRING" id="86630.A0A367JDT9"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH87891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="82" mass="8991" checksum="F62B97799731A3D0" modified="2018-11-07" version="1">MSIADAFECTIDFDGQRLVDKLMHILLIVTGIISFVSGYSTQSLQVLLIAFASGLGVTALAVIPPWPIYNKHPQPFIQNDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JE96</accession>
    <name>A0A367JE96_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAB-dependent poly(A)-specific ribonuclease subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN3_3</name>
        <name evidence="9" type="ORF">CU097_010449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001496">
        <property type="protein sequence ID" value="RCH88282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JE96"/>
    <dbReference type="STRING" id="86630.A0A367JE96"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="188"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH88282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="528" mass="60067" checksum="573B0B85110EB41A" modified="2018-11-07" version="1" fragment="single">NATTSQVDNMKPKTPTTSTISNVNAPEFVPRFTSEGNTPTFAEALTSTNVTSTHEPSTLQLNDSFSQLNISPHDQVDQQPAVAHDQLLEAGHDYIQQHPFMLPAADPYMFMNHSTNFLRQPLQHHFYSSSLSHTKVPLLPHQRLINSFFIPDKLREELTQRNEAQWMTSNDQSLPAEVHVYHSLYPLEQEKLGNYNGYPATVYKATCSIDRRSYALVRIEGYSNVNESAVSIAEVWRNVRHCNIVSFREGFTTKAFGDDSIVFVYDYHPCAKTLLQHYFRSVNQMFKPAVSTQSKGAPLLVSEKTLWSYIVQITSAIKAIHSSGLACRNIQLNRILITGEGRVRLTGVGILDVLQGEADQQLIEYQQQDFISLGTLIIQLACNLSTPSQNITQSLEYLSRMYSEDLKILVSVLMDENTPKSIDDILTLIAPRILEKINRNHFHNDDLEQCLGQELENGRLVRLISKMGFINERPEFDMDPSWSETGDRYLIKLFRDYVFHQVDEHGQPVIDMVHVLTCLKKALMKRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEU6</accession>
    <name>A0A367JEU6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADK2</name>
        <name evidence="10" type="ORF">CU097_010182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01001467">
        <property type="protein sequence ID" value="RCH88440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEU6"/>
    <dbReference type="STRING" id="86630.A0A367JEU6"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="36"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH88440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="272" mass="30927" checksum="5A3FEC6A6F72189A" modified="2018-11-07" version="1">MLLLRNSFIRIHKRSFHDCPINSIQPLRLLLIGSPGSGKGTQSSRLVKNFGVTHLSSGDLLRKNIREGTWVGQQAKQYVTDGKLVPDGLLISLVNKELLHIGATNWLLDGFPRTIEQAKQLDASLRQLMQPLNLVIHLQVPEEVILQRIMDRWVHIPSGRVYNLSYNPPRVPGLDDITGEPLSKRSDDNPEVFKVRLDQHHRMSRPLLDHYKDIVVNVKGNTSDEIYPQIEREIVNRLGILPGHIPDVSPISALKKEKVYKQEKKEHQASNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFG3</accession>
    <name>A0A367JFG3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001435">
        <property type="protein sequence ID" value="RCH88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFG3"/>
    <dbReference type="STRING" id="86630.A0A367JFG3"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="237" mass="27369" checksum="1B8BB60D471FF0CE" modified="2018-11-07" version="1">MSTLPLPPRIIARVRAVYPYYSEEKSSLSFKKGDYIDVLAKLDSGWWDGVCNGERGWFPSNYVELVREDMGMLSRPPDKGLPPRPINGNRASSIYSSSAGSEVSRNNANLPDGWTIQMTEDGRAWYYYNEHTGKITHQHPLLEQDSEPIIEKKDQRIDHRDSIFYPSQPIEEDIDEHANDYDTGPSAQELMDSWVERKTPQGRVYFCNLLTQETTWDYDEIDPETGRLNLYTHIPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JG83</accession>
    <name>A0A367JG83_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_009645</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01001389">
        <property type="protein sequence ID" value="RCH88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JG83"/>
    <dbReference type="STRING" id="86630.A0A367JG83"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="125"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="450" mass="49542" checksum="A057D630FD616931" modified="2018-11-07" version="1">MSEKKILLLGSGFVAAPCVEYLARRPENKITIASRRIENAQALSAKFPGTIAVSCDINDDKAIEDLVAQNDVAISLIPYIYHAKVIKAAVKHKKHVVTTSYVSPAMMEYDQAAKEAGITVMNEIGLDPGIDHLYAVKTIEEVHKEGGKLKEFISFCGGLPAPEDSNNPFGYKFSWSARGVLLALKNTARYLERGKVVEVSGTALMDSAKKLNTGYPGFAFVGYGNRDSTPYDKRYNIPEAETIIRGTIRYDGFCQFVKALVILGFLSEEEEAHLSANAEDITWSQVLAKTLSVNDTSDEALQASVIAKCDLDNNEYKAQILDGMRWLGLFSSTKVHRRGSLLDTLCATLEEKMQYGPNERDLVFLQHRFEIELKDGTHQTRTSTLLEYGKVGGYSAMATTVGVPCGIATQLVLDRKLTQTGVLAPMTNEINEPIIELLEKEGIGMVEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHV4</accession>
    <name>A0A367JHV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001314">
        <property type="protein sequence ID" value="RCH89301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHV4"/>
    <dbReference type="STRING" id="86630.A0A367JHV4"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29442" checksum="2031FD400D0BB9DF" modified="2018-11-07" version="1">MDRLRKAFSIRHDHHMSTVQHKKSATDISLNNPTSSSPSAATRPRSLHIDHDVSGIHIAPLKKSIQKENISIPADDDKEEYLQLGLKCHERGELEKATHYWRLSAERGSSLGSFFYGIALRHGWGCKKNPIKAVKYLQNAAESAVYELQTNISQSAIVAKSELVLAIYELGICFRHGWGVPKNLETAAYYFQIASNLGDPDAQNDLGFCYTHGIGVKKDLYAAAKYYRLAEKQGQGIIGNSWIWKEKYNKVEEPGWAVKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI76</accession>
    <name>A0A367JI76_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cytochrome-c oxidase</fullName>
            <ecNumber evidence="4">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome c oxidase polypeptide II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">COX2_1</name>
        <name evidence="17" type="ORF">CU097_010457</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01001249">
        <property type="protein sequence ID" value="RCH89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI76"/>
    <dbReference type="STRING" id="86630.A0A367JI76"/>
    <dbReference type="OrthoDB" id="539285at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13912">
        <property type="entry name" value="CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034210">
        <property type="entry name" value="CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="16">
        <location>
            <begin position="65"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="205" mass="22965" checksum="7AB1950D004DFD0D" modified="2018-11-07" version="1">MTFSLWSTFVQCDAAEPWQIGFQDGASPTFEGSIVFNYSSTSNPISHKYSNHGTLIELRIKDVISPAMTIKAVGHQWYWSYEYSDFVNEDGESIEFDSYMIPDSDLEDGQLRLLDVDNRVVLPVDTHVRFVVTGADVIHDFAVPSLGLKIDATPGRLNQVSVITEREGVYYGQCSELCGVYHGFMPIAVEAVSLDKYLSWLDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JIF7</accession>
    <name>A0A367JIF7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NPT1_2</name>
        <name evidence="9" type="ORF">CU097_012229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01001237">
        <property type="protein sequence ID" value="RCH89724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JIF7"/>
    <dbReference type="STRING" id="86630.A0A367JIF7"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="198" mass="23953" checksum="56FB76DBE05DAC60" modified="2018-11-07" version="1" fragment="single">MTHQVFPSILDNDLYKFTMQNAVFTYYKRDIPVVYQFTNREKQLQLNAEAVDWLQKQIDDLENLHLTDAEREYLSGYPYFQQDYIDFLYQFRYKPKEQVKLKFDKTTNDLELEVVGNWHETILYEVPLLALISEAYFRFVDKDWNYDGQYEHAAEKARVLLEHGCAFAEFGTRRRRDFKTQDMVIRALKETFETYKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJV4</accession>
    <name>A0A367JJV4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_007547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001157">
        <property type="protein sequence ID" value="RCH90217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJV4"/>
    <dbReference type="STRING" id="86630.A0A367JJV4"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH90217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="39439" checksum="D3E7A1F617B161A7" modified="2018-11-07" version="1">MASLETEPLQTIQLDGLVVLKIIKHCRESYPNDVTGQLLGLDDKGVLEVTNCFPFPSDGDEDTSAQYQLDMMRCLRAVNVDNNTVGWYRSAHLGSFVDLSLIETQYNYQNSLSAQSVVLIHDVSKSAAQGNLSIRAFRLTDAFMKAYEAKKFTTESLAQAKLSFSTIFEELPVQIRNSHYVTLMLHNIEMPKLNADRLGYLSTFTSSKKTQSELEEARPLAPNFDVLDLELDPFMQKNLQYLLDCAELQQQEQYNHQYWKKAVAREQGKMQAWLTKRKQENAERIEKGQQPLPEDEVNTLFKLPPEPSRLDSMILSAQMHNFTKQLNQFAGPSLTRLYSIQELQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JK97</accession>
    <name>A0A367JK97_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HHF1</name>
        <name evidence="13" type="ORF">CU097_006770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001138">
        <property type="protein sequence ID" value="RCH90336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JK97"/>
    <dbReference type="STRING" id="86630.A0A367JK97"/>
    <dbReference type="OrthoDB" id="2384071at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH90336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11452" checksum="8F273BB8AE0D9787" modified="2018-11-07" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRNVLKTFLENVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKM5</accession>
    <name>A0A367JKM5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylmalonic aciduria and homocystinuria type D protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001111">
        <property type="protein sequence ID" value="RCH90504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKM5"/>
    <dbReference type="STRING" id="86630.A0A367JKM5"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20773" checksum="6DE64E649E766E16" modified="2018-11-07" version="1">MTSTNSKERLTNKTSSCVIQPTILEYNGSIFEYSAYKPTMRFLRDFDSIFPQLSSRQKAQLLVVPVIQKCEHDMVGLSKEVNDERDIKLELFISWGRRVVDRIKSVGMWADMMDPASGFPVFSHPGSSPYPDVQGTIMLDSRFDVQNVGCCHILLHPSWGSHIYPSTLFTTAPADILEKILLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKX5</accession>
    <name>A0A367JKX5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inhibitor of growth protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ING4</name>
        <name evidence="4" type="ORF">CU097_006204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001099">
        <property type="protein sequence ID" value="RCH90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKX5"/>
    <dbReference type="STRING" id="86630.A0A367JKX5"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="212" mass="24786" checksum="3A6536D90BD67580" modified="2018-11-07" version="1">MTKTTKESPLTAAFLGEYSDTVEDLPLELRRNYTLIRQLDDNAEELMYQVEKETMLLTTSGKDLSPEERKKKLEHISNLLKEVINKGEEKYALAKSTYDSVDRHCTKLDNDLERIEAEQQLLEPTHRMYEHAQYESIKPSQGESRRGRKKKTNEEDYSSDNLQKEISFSNMPIDPNEPRYCYCQRVSFGEMVACDNPGCEIEWFHYECVGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JKY9</accession>
    <name>A0A367JKY9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001101">
        <property type="protein sequence ID" value="RCH90576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JKY9"/>
    <dbReference type="OrthoDB" id="2288755at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="107" mass="12234" checksum="97A76DE2962168C6" modified="2018-11-07" version="1">MEKHPCDNTNIKVWASNGRHSSPKSFVKSISPGRNECCHYSNKDCTPRGVDYDEMTFDVMFWWPRYASGRFSLLCVAGGGLAFYGTETNHWAECTQLDGQTRRIDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL32</accession>
    <name>A0A367JL32_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_000379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001087">
        <property type="protein sequence ID" value="RCH90660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL32"/>
    <dbReference type="STRING" id="86630.A0A367JL32"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH90660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="19756" checksum="49D82DC4D26CDF3A" modified="2018-11-07" version="1" fragment="single">GKQDVKVNITPIHGSFLEADPNDPQYSQVEYLLLDPSCSGSGIISRLDHLVDDEDENEGSSDKNGSTQEERLKNLSEFQISVIEHALKFPNAKRVVYSTCSVHAEENEHVVKTVLKNNPEFELASRDTVLPTWHRRGMPKEMDGDEDKVETVQEAKPNKKKKKNNKKKKTALTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JL33</accession>
    <name>A0A367JL33_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_011732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001090">
        <property type="protein sequence ID" value="RCH90643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JL33"/>
    <dbReference type="OrthoDB" id="10354280at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="28998" checksum="84FC1C8D48656F14" modified="2018-11-07" version="1">MTLKGCRRPIDDSTQMEFIRTLAKCTIEAFKLQTRTVNSMEFTKVDYEPDALSGGDVPHRFHKLTFQRSRITLTPFRDDGSPTQIQDLTFTYIKLRSFQTYYYNSFQTLSLSIIFVDTRFFRTLGRICSKLKALELGMGPIRVHGNEGVIDIQDLMLQRLDLAILPRDFSEYPWLVVVKTHKEYAYIKIHKNRRYNVLTYEEAMEEERQTQFSERYHIYCYDIQEVFRSNKKITLYRNSTSSNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLP5</accession>
    <name>A0A367JLP5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001058">
        <property type="protein sequence ID" value="RCH90853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLP5"/>
    <dbReference type="STRING" id="86630.A0A367JLP5"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="2">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="2">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH90853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="563" mass="64180" checksum="118055DF3083FD6D" modified="2018-11-07" version="1">MSTEMQSVFEAFDNYSWDSDPVFQAGYQSIMASMPADNTRLLKAKHFYFSKFQQSFDLDAYLQYEKEKKHALYERVEDYDYENDETFVKGLPEIIKGYVEQQKKGLWDKDKLEFELRKAKAFYYHAKVEQFDIPDYFNYITKKQDSKKPACPFANLWQNKGTVQTQEQINGASFVVAEEPKFTGAIKITLSSPTSKNILSIDRLDELQRTLERANDDHVTCMFLTATVYDSPTLPKEIIETNDTKMICCGLPYEETSRLVSGSDLRQTSLFKISSAYYDLVRTFLTSSKPTVCFLNGQIPLNAAHLFLLPKHIRLITEHALLNLGLDLSHSPIPPLTILKSCSKASVIFYLAMAPPVKLRGPELLYLGLADFFVPELKLSDAFDTARTMAICTVPDQAVRLALGTRHTYAGPNRITVWQDQIEQVFESAESFESLKSQLESIHNKWADTILDHWNSLPPTLLKVVFRAVKQMDTMEPIDVLELEQKLNAKWRQTEDYKEWLRSGKNWSDEEDVEFYFTDLALPSLSDGVVYQAPVEQESQALVCPVTGQTASSCPVAGVMNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM69</accession>
    <name>A0A367JM69_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001067">
        <property type="protein sequence ID" value="RCH90791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM69"/>
    <dbReference type="STRING" id="86630.A0A367JM69"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="315" mass="36629" checksum="B4FAA89BCB7EEF9D" modified="2018-11-07" version="1">MGNQSSKINIQNKKKQDAVIKPSMPISTNIGSIASSRRSSITEFFAKRKQSIASIMKREEDIKEHDREQRQHYLLKNVRKGNTRTLLDSPKRIVESGIGNGIWVLEMATQYPDAQVIGLDLKLPDIQLSNQTFYRANIIETWPIEPDSVDFLFQRNMVTCLQKDHWIHVFSEMFRVLKPGGSLELIEQDLLHHNPGPVLQALHAFYKEQFDQTKIDWELSTLRDALSQIGFIDIELMTIDIPIGEWPTESDQKQFGFMNKDIQKAFLKNKKNEYMQRWSMSSVDYDVAVGEVCDEFEEYQSFTRVNCWMAKKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMB2</accession>
    <name>A0A367JMB2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_002506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001030">
        <property type="protein sequence ID" value="RCH91035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMB2"/>
    <dbReference type="STRING" id="86630.A0A367JMB2"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="11">
        <location>
            <begin position="405"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH91035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="603" mass="67209" checksum="534E67385143FB87" modified="2018-11-07" version="1">MAEGGHNGQQQQHQQQQPQNLGPEDLNFSINDILNGNSVVNDSSFQTIVQTFSDTSNNQDMMPSFAHLPAELQDFFSSSETDDLLSTQNASIPHDLLFNADHTQPFVQQPLKIQTNPTGSPQPQQTAIPRAPPQQQQLHQQPPQQQLATHSPQPHVLPPGPLPQALAQPIQPSQPAVPSLPQQASSTTLLDNITSQLPPDRKEKFMQLFRDLQTSTISAAEFMAQAKAILGQQQYQQLEDLKTRPMINQHQMQPQQQQMMEEDQRKRKLNPASNISSPQIKKPKSEHIPMNAINQQMTYPMMTPPRVPTSQPPSILPQQQQQQYPIQPNIVTPSIVKPPTPVGPQQPQQQSPFKAMDAAVLQIPTKSNIAVPSTSKLPGAAAPTPTSTGGGGGGGGGDRVDYEALTDVMGYAGVDLKEEAEHFMKEDAPGTVLPDGIDRSKFQDFMNPTMLRDRILKYAKSVNIKKIDGDFISYLALATQDRIRTVMENMVRASRHRTENPFKKPPEQDNHPLYKIHVKQKVKDQLKAIERAEESKAKMDEEMDDVLNSEKGWYSKKSRVPLKAESIERKITVQDAIFVMERDVQGGRGTNRRTLLKAYNILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNJ4</accession>
    <name>A0A367JNJ4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_006879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000959">
        <property type="protein sequence ID" value="RCH91512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNJ4"/>
    <dbReference type="STRING" id="86630.A0A367JNJ4"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="331"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="434" mass="48414" checksum="FFD6885FD9B50C0B" modified="2018-11-07" version="1">MFRANDDNKPFKVLIVGGGLAGLALANGLKNKGISCEVYERDVDPDSRTQGWSLSMHMALQTLYDCIPKHRFEYFGREVGVNHEKNEGGMTFTNFNGLTGEIESSLTAPPYKAYRVNRKRFRKWLLQDVQDLVHWNKKVSHYEEHADGVKVFFADGTHAEGDLLVATDGSMSTVARQLLGEEKFQSMTRIHNVRGYGCSRWISEEEWNALAPEGTISGIIHGRMPADVPDDGFSKPALIFYSLNKVDRSRGNTPYDVLWFLSRYTENPSPPTPDGSNNAEIMKILKSCATNAFPGVTAHQQFVVNTPDDTPLVGITIRERVPVYDAYMANTQRVVLAGDAAHPMSMFRGEGGNHAILDVGVLVNEINNVVSNSKPLKEAISDYYKEIIPRTEQAVEASSKAATIMHTNPEAIRQMMEERTALVRKSLEEEEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNZ7</accession>
    <name>A0A367JNZ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000946">
        <property type="protein sequence ID" value="RCH91605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNZ7"/>
    <dbReference type="STRING" id="86630.A0A367JNZ7"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="63" mass="7046" checksum="998C9EC7D3A935FD" modified="2018-11-07" version="1">MSTKLSPAGRRLATIIVSAPFVVVTTWILYKRVVLGEKPRVSDGHAIRPMGVRERDEKDSKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPY5</accession>
    <name>A0A367JPY5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000889">
        <property type="protein sequence ID" value="RCH92010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPY5"/>
    <dbReference type="STRING" id="86630.A0A367JPY5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016694222" description="Fungal lipase-type domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH92010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="287" mass="32910" checksum="AD363CF7797B2A1F" modified="2018-11-07" version="1">MLVKKLFIYVPFITSLIQVGQCHRTAQRNRDNRWPVVYTNDQAKTITYDPTQPVDIYIDLIKDGIFMAPNETSLLPSSDVVYTYDETSPIAKELMFVSALCKTTNCRESLDVWDCPTCSEVLPDAVVVRTFKTFPNDITGQILRSDNMTTFFIQVRGANSNSNRILWSKQNLVDHPFIPDVRVQEGYLESALDIREIIRNTMKDQLTIYPNYKVAVVGHSFGAGVCSLVATHLQYDFPQLNRNNFKTYLLAKPRVGDYNYAKYIADKDIEIVRLVNALDGKYIYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQ19</accession>
    <name>A0A367JQ19_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_012840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000920">
        <property type="protein sequence ID" value="RCH91791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQ19"/>
    <dbReference type="OrthoDB" id="2279327at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH91791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="227" mass="25857" checksum="9B0389D4E9916DDA" modified="2018-11-07" version="1">MFDIPNQFIVSSRLSTLDSQDILAILQIAQSKWDERILLERMRKHPKTPLICIGISNPQELERVIGHDIPVIHIQPDCKALQRVQERHDRYQGCINQLLWIGTNSLWGLLGYSIQIIVGPSPDTVATAIQLNPNVYSVGYQIYGFGQTIWNKLAVKKIMQRVPPKWLGILCGSGVCLSLWTQLGLLTEFSSFDSFEDYLIVNSIDLFMQKTAIKPQRRDLEPVLLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JQB4</accession>
    <name>A0A367JQB4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin type-2 heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MYO2_5</name>
        <name evidence="2" type="ORF">CU097_001652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000879">
        <property type="protein sequence ID" value="RCH92075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JQB4"/>
    <dbReference type="STRING" id="86630.A0A367JQB4"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH92075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16664" checksum="81FAE71426D66505" modified="2018-11-07" version="1" fragment="single">LEEWCKAHDVSEATNKLEHLTQATKLLQLKKSTIDDIKNIYEVCWCLAPTQVQKLIQNYSVADYEDPISNEILRAVASRVSSSNTEDILLLDNTSLEESDYDQPEPHHVDINSYIPDYLNIQHVQRLVALANLSEQRKPQRMDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRI4</accession>
    <name>A0A367JRI4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_008906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000811">
        <property type="protein sequence ID" value="RCH92560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRI4"/>
    <dbReference type="STRING" id="86630.A0A367JRI4"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH92560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="565" mass="61521" checksum="6D43166952E646BA" modified="2018-11-07" version="1">MTTTEVEPTERSPLLKHQNEIRNSKYPILEDDTGDRVTVVTSPNSPLQKSPSAEEILERRLNGAPRWTIFLGLWVGVALASLDASIVATIYPQVGTEFKRSNEVVWIATAYMLSYTALQPLYGRISDAFGRRTSLLFATAVFFIGSAMCGASSTLWMLVVSRGIAGIGGGGMNTISAVITSDLVSLRERGKYQGYANIAYGLGSVVGAPLGGLITDKLSWRYCFYINLPLLVVSLYVAIYLLTDYNLEEQEEKSFIKKLKNIDYMGASAVVSSVVCFLLATSMGGNSRPWSDPLVYGLLIASVVLGVIFCLVEKYIARNPLMPWQIISSRTPLACALSNFFVIMGSFATTYTAPLFFQGVLGYTPSQAGLFFLPKVTAMSIGSLSSGFWMARTGEYRKFIIVTSFIAALSMIGTSTWTHDTSFSFIIICLILDGFSSGAIITSTLVAMLSCVGSGEMATITSVSYLFRSTGGVVGVSVTSAIFQGLVKKILTERIKGPDAEKIIDIARKSMTEVRDLLSPEALAIVLDTFEIAVQYSFYFCVVVSIFTVIASLFIQQFTLHARIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JRK0</accession>
    <name>A0A367JRK0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">37S ribosomal protein S16, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_012926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000821">
        <property type="protein sequence ID" value="RCH92489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JRK0"/>
    <dbReference type="STRING" id="86630.A0A367JRK0"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11573" checksum="244E140332BBCF10" modified="2018-11-07" version="1">MVVRIRLARHGRRNLPFYNIVVANARTARNSKPIEKIGTYNPIPDREGNKMITLNFERAKYWLTVGAQPSEPVEKLLVKADLLPQAPKPWMETAAKKFKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTG9</accession>
    <name>A0A367JTG9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000734">
        <property type="protein sequence ID" value="RCH93149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTG9"/>
    <dbReference type="STRING" id="86630.A0A367JTG9"/>
    <dbReference type="OrthoDB" id="2367755at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="203" mass="22808" checksum="A78E47625FC924CB" modified="2018-11-07" version="1" fragment="single">MDSIRFIQIHEKEESYKQDVTIRAVLPAKQAFALVGVRGQHVQQIEKDCSVTLRVYPVIGRLVSISGQPENVSKAWTMCLGYLSNRYPAQYTTDVAINFLLTRDLVTLLRDPLETNFSFEYIARTTGTRIYLKEGTLPESTEQIVRVSIPTMEQVNLFKGAVCLLADNICAYPQLAMSPETTYFIPKGHQDDIAVSLMNDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW00</accession>
    <name>A0A367JW00_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_012846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000626">
        <property type="protein sequence ID" value="RCH94039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW00"/>
    <dbReference type="STRING" id="86630.A0A367JW00"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="504" mass="56811" checksum="0A40D433D552081C" modified="2018-11-07" version="1">MRYLYQLNRSFKLNRAILPNLLSVKYIHTKNNAVKSQHYPVASCPSNPPMDFPCIDKLNTRTAELDNGPEPSYDKIVTGYEKFEYPHPFLLDHGGILPNFEIAYETWGQLNEKRDNAILIHTGLSASSHAKSHPKNTSPGWWENFIGPGSYIDTNKFFVICTNVIGGCYGSTGPSAIDPADGERYATRFPIITIFDMVRAQFKLLDHLGIDKLHASVGSSMGGMQSIAAAKLFPDRVNRLVSISACARSHPYSIALRHTQRQVLMADPNWNKGFYYKGIPPHVGMKLAREIATISYRSGPEWELRFGRKRANEHQTPALCPDFLIETYLDHQGEKFCLQYDPNSLLYISKAMDIFDMSQSQFKKLQNQRRENTPKFEQVLQRSGGGDSRQLAEACRSVVGSDYTALEGQKRESADPHPDPIRTDLVEGMKDIHMPALVLGVQSDILFPVWQQKEIAECLREGGNKHVTYYELDAMYGHDTFLIDRVSVGGAIKGHLELLDRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWZ3</accession>
    <name>A0A367JWZ3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000579">
        <property type="protein sequence ID" value="RCH94427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JWZ3"/>
    <dbReference type="STRING" id="86630.A0A367JWZ3"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="140" mass="15618" checksum="E542F558DBD49E4E" modified="2018-11-07" version="1">MLAACRNDQDEMLEDILKEGDFDINYTDGLGDTACHYAAKFGAKNCLELLVHIPSIDLNRKNKEGKTPLHLAVQYDDDPDIALDMVDLLLNSGADPRVKDNQGSTILDHVVNEDMRDLIEQSLAGYNMGMSDNDDEDEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JYZ0</accession>
    <name>A0A367JYZ0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin-binding FH2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_010951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000490">
        <property type="protein sequence ID" value="RCH95212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JYZ0"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001265">
        <property type="entry name" value="Formin_Cappuccino_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00828">
        <property type="entry name" value="FORMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="65"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="844"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1273"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="732"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="796"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1296"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH95212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1368" mass="155271" checksum="8E84F9CA8F200B32" modified="2018-11-07" version="1">MDLFSRGKSKGKKKTEIVINTHQPYSSSPHSPKSPDDYLSHKTEGSIRSSQSSSIPSNDSDFTHVDMMTDAEVEECFERMLTRRGIHDANARLKMSSFSVDKKRIMVAQDIQSESNATQPTSRRGGTDKKIEEGKGPDYYVKKLSDTSKGVNANIVSHLAVGLRTMPLSWVRQFIDMQGLQVITDLLTTLNKTKHRQIGAREALRHPQCVQEIVNCITSPSIQSRRLVCEVLVFMCYYEIPVGQDLVLKAMDKLRDKERGFGRFDAWLAEVEVTLGGRGRMGSMVGASEDFKKMAAYGSPDNQLIEYVLYNMILVNAIINVVEDVEIRIHLRNQMNASGLERIMDKMKELADEHVDRQIREFKLLAENDQDELMDVYHENVLNDKDDPREVFEYLLSTVEGTRAYDFFLSCLQHLLLINNEEANLKSRYFQVIDNLVAQVVLDHKGLSDDFSADYNTTVQHLIDRFADQDQLKTTLEDLKELQTNYEELERERDLLRQQLFHEGDALEVVQLREKTASLEDLLRMSRHTISTLQQKLRDLQNEYDANLEQAGKQLEDFYKLIDEDGASLEGNIMISRKDLATAFGRIRAQASLEGHHKKESDIVAKKIPSEKDETKYKSLAMGLSEEFKMQLARQFGSSSGLGEFVLPGTMPLMGSAVRRSNNRRRQAHVSEIQEVVEPEIADTNTLTLRKSKRISSKEHDNKVDRANLEEKIETELAIASTEQEIEKTITTATNDTVEAETPIKQVSLDHKHIPSSTADSNVTSNNIPPPPSPPSSLLPSGQPNNTSPTPVSLPSAPPAPPAPPAPPGPPGPPAPPAPPAPPSAPAPPLPPGTPNAVAAALRKQMKHLPTVKTRQLQWQKLNANYINSTIWKTSDLEEKEEALEELFDSEGIFKRMEEIFAQRVIAPKREVTKEKRQEIYIIDTRKAHNINIAILAKNKNVSFQDFKKKLLAVDERFCTEVLLRNLLVNAPTHDEMGKLSVFLKTASEEDLQCLSKSDAFCAEIMTIDRFKERLNHMLFYTTFNERITQLGKSMANVMDASTSLKESEAVKDLLNIVLMVGNFLNGTNFQGGAFGIRIGSINKLVDTRASTNNTTLLHFLCTMVEEKFPNISTRLVKDLELCGEACRVTIQDLIKDYNELRVGLQSLIHELECHYGPDYEAEEGDNFASVMYKFRDRAIEKFDQVEVRYTSMDIAYKDVVSYFGEDPSEMKPDEFFGIFQTFLSSWTRAKADIELQRKKKEQAEKARQYQEQRKARLKNRLDIKDGPAENQDDKDIMDNLLEKLRSGEMGTTQQRRSRRISMRERRRTRAESMVVRAEDLLRHIQNEEEAPPLPRSRRGSRRITSSDRMKKLASLAEQENRSSIIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JZH6</accession>
    <name>A0A367JZH6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CU097_011861</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01000477">
        <property type="protein sequence ID" value="RCH95343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JZH6"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1548"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1575"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1602"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="7"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="913"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="746"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1706"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1706"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1725"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCH95343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1743" mass="199144" checksum="03B9FF7D613D9FCE" modified="2018-11-07" version="1">MYHHPTPVITDLCSLPDVDDATITDRLRTRYMNYQSYTAIGYCNIIAVNPFRRLAQNDTQTSEEYVAFYKNPSINSCFKLDPHVFGLANASYFRMRRTGNGQVILLLGESGSGKTEIQDLIIPHLIRLGSNKKKQKMQEYIIGGHKVLNIFGSATTSPIARYSSRFGVYSEIHFNERGKVVGGNIATYLLEKSRLCGGFSKARSNEGNFTVFYLLLAGTTPDEKQVLQLTDDPKSFHYLAPYSRSISSSDAEQYNELKSVMRTAGYKKDYFNFIIQLLSAILHLGNLILMPSDGAEETVSIKNMDCLELIAGFLGLQPETLKSSLAFKTVTIRKDTTTLILDANQAIAQRDDLAQTLYSLLFTWLVSYINRRISCDNYNSYAGILNLPGIQLTAMNTADFYQFCINYANEKIHDFMMDRMFVADAFELESEEIKASKVHMRENKRCLELLERPHHSICALYNKVTEKMLSGKKMVSNESAVEAISKFNAGYEEVSIHKSDTGARLFAIRHFVGDVTYDPKDFVSSNNNQLSQDFVSLFRGSADSPGSLNNFVVQLFSDENIAADTHMHPEVQQKDISNASLSVKQRDEKDEGYFQWSSNKRTVLAQTKKSMDDLISTFQEANLWTVFCIRPNNTGSSTDFDSYLIKSQVEMYGLRHITHKMNEFYTISFLHQDFLKRYSSLLYIPDEDEGAKPHELCKMLKQSSSWTDNDIAIGITKVFLGYSLWYSLEERLRILEKEEKRNSKTLLEEQVGANTKVHSSSPQEDQQTSWPDRMNYMRQPQSAPNDIGRAMLNARSSSLVGSPSSNPSFVPEEDRTPGTYSPPNFPDTYEQDTNATEEKPSTMTPGRKRWLALVYALTFFIPSFLLTKIGGMKRRDVRIAWREKLALCFIIAFMCCFVIWFLVFFGELICPHQSVFSMKELQGHQAPDNAYVAIRGEVFNLGEFASHHYPSMVPTKSILTYAGTDASELFPIQVSDLCENVSPYVSLDYQRNYSDPNAEYHDYTYSSGNYKQNWYYDQMTMLRKNYKVGHIGWEMKAINDQAKGAYKMNGQSMNRYWAVINNAVYDLTPYILGGRYVSAPPNEEAPANISTDFLDISVVNLFWQGSGTDITEKFNELPISNDKRYREIACIRNLYFVGMVDSRNSIKCQFSTYFLLVITICLCIVIFFKFLAALRIGSPRMPEDLEKFVICQVTCYTEDEDSLRKTIDSLATLNYNDKRKLIVVICDGMIVGSGNDRPTPRIVLDIFGVDPQVDPEPHSFLSVGEGTKKHNRAKVFSGLYQVRGHVVPYLVIVKVGAPNERQKPGNRGKRDSQLITMQFLNRVYYDAPMNPLQLELYHQIRNVIGVPPEFYEYVLMVDADTEVMPDGLSYLVSSMAHDAQIIGICGETALANEKDTWVTMIQVYEYFISHHMIKAFESLFSTVSCLPGCFTMYRVRTVDGKRPLFVSNEVIEDYSVNTVDTLHKKNLLYLGEDRYLTTLLLKHFPNFKTKFNPDAHCQTNAPDTWNVLISQRRRWINSTVHNLGELVFLPHLCGFCCFSMRFVVMLDLISTLVQPALLGYLGFLCYKLATAHNQIPYITIMTLGCTYGIQMILFIMNRRWEYVAWFIVSILALPVFSFYIPIYAYWHFDDFSWGNTRIVVGEKGQKVIINDEGEFDPKSIPLITWREHEKMMTPDIDQVSQRSSYLLHTGSAYGLPEYTPNPTYYRQQSPSYQMNASQSIPGSLFERESRTSERSRRYPNSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K028</accession>
    <name>A0A367K028_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACO2_2</name>
        <name evidence="12" type="ORF">CU097_007309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PJQL01000460">
        <property type="protein sequence ID" value="RCH95499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K028"/>
    <dbReference type="STRING" id="86630.A0A367K028"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="64"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="583"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH95499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="781" mass="84586" checksum="7F01DD86A608B707" modified="2018-11-07" version="1">MISAYLARSRVPTFRHAIKRTLATQHNPVAEKDCSSITPPYAKLNKNLDLVKRILDQRPLTLAEKIVYSHLTNPEETIPVRGETYLKLSPDRVAMQDASAQMALLQFMLSGMSTTAVPTSIHCDHLIAAHEGADKDVAQSIVTNKEIFDFLESGAKKYGIAFWKPGSGIIHQIVLENYAAPGGLMLGTDSHTPNAGGLGMVAIGVGGADAVDAMASIPWELKAPNVIGVKLTGQLGPWASPKDVILKLAGLLTVRGGTGHIIEYFGEGVDSLSCTGMATICNMGAEVGATTSVFPYTSSMRSYLQSTGRSAVSQAADSNAHFLRADSGAHYDQLIEINLSEVEPHINGPFTPDLSTPLSKFKDVVSQNGWKDELSASLIGSCTNSSYQDMSRAASIVKQATSAGVPLKVPFLVTPGSEQIRATIERDGQQQVFEEAGGQVLANACGPCIGQWKRSEKKGEENAILTSFNRNFRSRNDGNPKTMNFLAAPEIVTAMAFAGKLSFNPMTDTLLDKNGQKFQFNPPSGDDLPRQGFEAGRATYEPPSPTPTPDPSVEINIDPKSNRLQALEAFEPWHGDEFRNIRVLLKVKGKCTTDHISAAGPWLKYKGHLENIAENTLIGALNADTGKVNSAIDITNNKEDTIPEVAKSYKRQKIDWMVIADHNYGEGSAREHAALQVRYLGCPLIISRSFARIHETNLKKQGVLPLTFVNEDDYEKISSGDVIETVGVKDIAPGKPVQLIVTKPDGSKVTIDAKHTMSQDQIGWFKKGSALNLIKSMNHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0N0</accession>
    <name>A0A367K0N0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000440">
        <property type="protein sequence ID" value="RCH95699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0N0"/>
    <dbReference type="OrthoDB" id="2279077at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="116" mass="13001" checksum="9087C807F3F07E3C" modified="2018-11-07" version="1">MIPGVWNNTTERLFADGVGCGDGFEVIIMESSGPLFTEDIDHFIEDTWKLITMTTNSLRNEILEYQDASIEAVKGLAVFRIQYICGKITSATIPVTWDSRTGMMSVFELLTTLQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K1S7</accession>
    <name>A0A367K1S7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_011398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000426">
        <property type="protein sequence ID" value="RCH95851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K1S7"/>
    <dbReference type="STRING" id="86630.A0A367K1S7"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="39"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="256"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH95851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="80725" checksum="CF0AA2ADB1530E31" modified="2018-11-07" version="1">MLLFKGYVFVKGFVRNYSTTNTLSTLRHYQKECIEACLKELKEGCYRQVVSLPVGSGKTVIMSNLIPRIPCPTDRATKVLLLAHRQELLNQAYNQIKRYNPNLTVEIEQGRRVAKYESADVIVASVPTLGRSKSNRIDNLDPSLFKAVLIDEAHHAVADSYQNIIHHFSESNNKVLIWGCSATVRRHDGLSLADVFEKVTYHMDFLDLVEQGYLCPMKVTTVQTSIDLSDVRHYGGDFVISQLSNAVNIRARNDVVISSWKNYAAGRQSTLVFAVDIQHTQDLCNAFRQQGIEANFITSKTPEMTRQQIIQDFRDRKLPVLVNCAILTEGTDMPSVDCILMARPTRSATLFQQMFGRGLRLHKGKKDCLVIDFADNFERGGTAGIVTIPTLLGLSSKKELTNVDILDLEKQAEKEEQEIEGQEKEVRADDRTTKREDVQEKNLPQADDGIDSDDSKIQIKVTEYGEIKELMADISPRKDIRAASRNAWVEIGDDKCVLLVLTQGSLILERDESSNLWHGFFKYDKRDTFAKRYSIPITSDTLTDAIRAADTWLRKKFPNSYIHNLIDRNARFRFAPCTEAQKDVLDGYNIKPKLKLTKGQAMDLITKVKYGQLKLWKEKHKKLKKEFEERQKFALLRRKPVNNEKQQQNTISCSSCHAPLPVDSRYRTCKAWRERLAGSHRRRRAEGQQEEAGVTTRPRGRPNANPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K240</accession>
    <name>A0A367K240_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_012817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000380">
        <property type="protein sequence ID" value="RCH96312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K240"/>
    <dbReference type="STRING" id="86630.A0A367K240"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="249" mass="28789" checksum="CE6E2BD514ECC409" modified="2018-11-07" version="1">MNTNFTQNDTTSKNNNNKPIEKPKRKQVKNACVNCQKACKKCDDGRPCKRCIKLGLTATCRDSDRKERKKGVKRGPYKKRQTLSKDKPVYPKLILEEQEYPPQVMVPSQTNATNWPNEFIGYNQPILSLSPTSSFASSDETLHYAYGYADNTLQPIIQDDFIPFEQQYCFSTQPTSFEKLLSVQEYELNLFEEPSYWYPVHHTTTSSSFTASPSSSSFFTAFPQTQPQQQEAYFDYNHTFQQPQLFSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K278</accession>
    <name>A0A367K278_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bleomycin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LAP3_4</name>
        <name evidence="9" type="ORF">CU097_013791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000381">
        <property type="protein sequence ID" value="RCH96303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K278"/>
    <dbReference type="STRING" id="86630.A0A367K278"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M17 leucyl aminopeptidase N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="7">
        <location>
            <begin position="168"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="487" mass="52814" checksum="E86015F5C696DABA" modified="2018-11-07" version="1">MHRLTCVRQTTRLFSTAKRFDAVIVGASVQNKKPTIETLDISQETRQLIEHQLLASNFKKKDDVRVLYDIKGLKQVAIVGIEQEKKNEPETARRATALGLHALKPLGAKKIGVDLSCMHAQGAGEGAVLAQFSFDKLKTKEKEDAIEVEPLKSSPDWEKGQIMAASQNVARMLMTSPSNLMTPKLFAEEVAYLLAGLENVEVIVRDEEWAIKQNMNAFLAVAKGSREPLRFLEIHYKGGKEGDKAHGLVGKGVTFDSGGISLKPSNNMALMKGDMGGAATVAGALYGIAKLKLPVNVIAVTPLCENMPSGQATKPGDVIKAMNGKSIEILDTDAEGRLILADALHYISSKYPLASLIDLATLTGAMDVALGNVFAGVFTNSDTLWTRLEAAGKTANDPFWRMPLHDEYLKEMQESLVADLNNLGKGRSGGACSAAAFLKEFVANNVDWAHIDIAGVMDSQATDGYHIKGMSGRPTRSLIEYIRKNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4M2</accession>
    <name>A0A367K4M2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GID complex subunit 4, VID24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GID4_3</name>
        <name evidence="2" type="ORF">CU097_012187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000302">
        <property type="protein sequence ID" value="RCH97164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4M2"/>
    <dbReference type="STRING" id="86630.A0A367K4M2"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="216" mass="25210" checksum="08BB639BF0AF392D" modified="2018-11-07" version="1">MPIVSVIPNANSVEKTTKDDAWVDISAKRLRSSRLGALYDGSRFKGMQKCGANTYNVIVDIQHVDLAASKISGYLNIEGLTTECPELTTFFEGEIIGPHYSFLTRKWQAQQSIDILHWGRFPSFEPYISVFNNDDFVYDPYDNDFVYMRWKEHFLVPDHCVSNIDGASFAGFYYICYQRSTNEIKGFYFYFNNHEWYQQLTLEHVEKNAFGNFEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4Q9</accession>
    <name>A0A367K4Q9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000302">
        <property type="protein sequence ID" value="RCH97167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4Q9"/>
    <dbReference type="STRING" id="86630.A0A367K4Q9"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH97167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="741" mass="83273" checksum="F60B811323167586" modified="2018-11-07" version="1">MSRKQPLTQRLTYDAALWLFNLMLDIFFREVRPRGAHKIPKDGPVIFVAAPHANQFVDPIVLMRECQRRVSFLIAEKSMHQKGIGTFARMVNAIPVIRPQDLAKPGEGFIQLLDRKRDPLRITGINTKFTQQLKPRDLIALPKSYGQSEVVEVISDTELLIKKEFKELKAMELLTRPEGTSYKCVPHVDQDAVYKCVHEELYRGGCITIFPEGGSHDRAEMLPLKAGVTVMALGAMAKYPGLDVKIVPCGLNYFHAHKFRSRAVIEFGNPLTIPAELVEKFKAGGTEKREACSTLLDSICNALKTVTVNAGSYETLMLIQAARRLYKPAHRKLHLSQVVDLNRRFLIGYNFFKDDPKVIELQQKVLAYNQLLKYHGIKDHQVLKTRNNGARMLWLLVKRIFVLAILSLLAFPGGILNLPVVIVAKVISEKKADAALKGSTVKIAGRDVLATWKLLVGLVLLPTLYALYSLIVFIIVLQMDMELKWKLLLPLITWNLLPFVSYASLRFGEIGNDILRSIKPTWVALLDPSGAETLRQNREKLSKDITELINEYGPKVFPDFDANYISRTTTTTSTAPSRSTSAANLSWTPSKLPKIASGFFQQATIMNWLDDKTIFNWSRADDSEVADDVFFYLDKSGISGRSRSGSASESDTRPHSRNRSRNNSFSSSSTISSVTEGFKLEGLTPTNNTLTVPDDNNKKRKATARRIFRIDDVDEDDQEVKLGNLAVSEHIIVTDETKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4X1</accession>
    <name>A0A367K4X1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000300">
        <property type="protein sequence ID" value="RCH97185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4X1"/>
    <dbReference type="STRING" id="86630.A0A367K4X1"/>
    <dbReference type="OrthoDB" id="2260962at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH97185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="804" mass="88699" checksum="837FAA6C4C79D30C" modified="2018-11-07" version="1">MDPQGQFNGAIVSAAPVWTVVVISILAIMLIVFITIFVRRFIRRSRMSNRNFNKKPSVESLETLVTAHQQKQQSKQLAKIDTHDTEKPTRSSSPMQPTNSATLARPEPQEEELEDGPPEPLQEIKISLPLPPPSTSFFADKMELDGSNCDLYDLYVHGKTDGMKRQSMHSVFISIDLDSISNAASNIQRKASTIRRSLYQSIRKPTSASGIKAVPAQKMFTDGTKEYSRQSIVAVNNERTQIGMPKASKIPQIEDVQQDEEPTAAAKRVIRSASKKAKSRSMVIHPDLPDDVVTPPKQETSKYATVRSIRSPDANEHVTISSGSVRRFMRQNSLFQGEDLPPESDPLPGTLSKNDRKPVANALDISKWWEGGESSNGVPEIRTNGMKNSESSLSVSQYRASLNDSVFALNGTISKGTGALFVPEPDKSKSDGAVSRNNSAKRGTLGRNTLKTLTANATQGVNKSIRGLFDQSSSLTNINKVSPSDSQKMEIDVEHGLSQQPIAPVESQNSRRKSYSHRLVPESPSKSRLTNTRHSIDESSQKVEADDIILKQSRSFSSKQGVEPAAQGVSYHKETIHSTQVSNTDHETDVAYIQQLGANKFISPRQTLLTKSLLAQQAKRSSSTSRPQDEPLQAPDPVVSFSSSTVRTVIPDDEMDHIQIRQNPMNQQQRLSIGMNGSNKVLASSFGDESSFLADRFSSMNAEQSRDHSRQSSGGTSVTTAVRISGGYPSSTWNGRAQKNGASRLSVIQTMDTEKESDIVEDKRGFFSTMRKDKKNRGVIPWMASEKMMTPAEMERDRYLNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K797</accession>
    <name>A0A367K797_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000228">
        <property type="protein sequence ID" value="RCH98045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K797"/>
    <dbReference type="OrthoDB" id="2239299at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH98045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11358" checksum="B5B3DD9FC91E47E8" modified="2018-11-07" version="1">MPSTTYKRSSSSASESELILKQDALPLFSKDKQAFILPPPSSLPGYHLPLPPLLKQQQQQQHYDDVSTAAATLASFAYEDEMCSESQVIEAAKILMNISRCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K820</accession>
    <name>A0A367K820_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000207">
        <property type="protein sequence ID" value="RCH98310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K820"/>
    <dbReference type="OrthoDB" id="2201970at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016969227" evidence="1">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="139" mass="15503" checksum="FE6B8006611C7724" modified="2018-11-07" version="1">MKFLQALLFTLAVYTASAYARVCCTIFDADQGHILNGTKDIASIFIQTDGRDHADCQVAMVINADIKYKGKCTFRESDNLVTADIRVNNADYHVSWNRSKDTCGAHSISVRASDWSNGKWELRQSSRSWSNCAPAWAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8I1</accession>
    <name>A0A367K8I1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_013437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000194">
        <property type="protein sequence ID" value="RCH98477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8I1"/>
    <dbReference type="STRING" id="86630.A0A367K8I1"/>
    <dbReference type="OrthoDB" id="2289276at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017074567" evidence="2">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="245" mass="27421" checksum="00A48AB42D596557" modified="2018-11-07" version="1">MRAIFTISTAIAFFTAAVFAADNADFDPVDFSAEDIATTLDSSFATFRWKGDSTMAQESFNLVAEEPTRIQVTDFKNLGDVFEVFDNGISLGTTSEVEEIAGEEVFAATPEEALEDERFSKGVFTLEKGEHKITIKATGPYEAGGKHWGKKNKGWFEHDSYKGHDNHKEHKDLELSPPYYDLDYSHTVTVTKTVWVEGTIPTPAAGDPITPVTPPTKDDDDKDLKIHDHPAFHDRDHDKDRLHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8M5</accession>
    <name>A0A367K8M5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000192">
        <property type="protein sequence ID" value="RCH98510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8M5"/>
    <dbReference type="OrthoDB" id="10533032at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016885700" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH98510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="110" mass="10327" checksum="D4E2E8D878326707" modified="2018-11-07" version="1">MKSQTFALVLVLLTIMTRDVAFAQSNVSSSVSATAEPAGSTSIDLAVSGASATADAAKATPTSAASISAPASASVSSPNSLASSISAASSAISSAATSISAASSLASSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8T7</accession>
    <name>A0A367K8T7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000181">
        <property type="protein sequence ID" value="RCH98643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8T7"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="327" mass="35515" checksum="F94A939C22EE68C0" modified="2018-11-07" version="1">MADTGSGHAGTPNLTWVNVAIASTFILVNGAISVALGLKLEKTLIIAAIRCLVQLTIMGFILEDVFKTRSPALVMLMACVLILLGAYETVYNKSKQSYRGMFISVLLSSGISTLVIGIIGSRWAMKQNPFWIPEVFIPTMGMLLGNAMSGMAVALSSCLSSVSNQKEQIETYLAFGASRWEAGQSIAVEAVRLSMLPTINQMSVIGLIAIPGMMTGQILGGAPVSNAVKYQQIIMFLISASTALGVLSAVIACVRVLIDSRHRLRPERIINGRASLLQDIKQTIISLWRGFIYVFCCLAKAKKKQTIDVDDDDEQQDEQRKPLLNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K908</accession>
    <name>A0A367K908_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_008019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000179">
        <property type="protein sequence ID" value="RCH98668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K908"/>
    <dbReference type="STRING" id="86630.A0A367K908"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="178"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH98668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32829" checksum="2BFE222DA29B7405" modified="2018-11-07" version="1">MSSNLQCSFIGLGAMGKNMAGHIAKHVESLGYPSLLVFNRTQAKAEELKKTHPVKVATSLEEVAKKSDIIFSCLLNDTAVEETVNDLVPHLKSGALFVEQSTISPKMAEKLAEKVSQVGATYLACPVMGPPAKAAAAELIVLVAGGDSNSRSKALSILIPAIGKKKIELGDAVGQSLRLKLCGNFVVTSTVEMLAEYMTLAEASGVGQDKAQELLDGFLPGTMVATYGSRMSQQTFTHEIHFPISSAKKDVNHIINLAKESNASVPITHKFLEHCNTAQEKHGDFDLTSVVGVLREEAGLPFIIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBE8</accession>
    <name>A0A367KBE8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_013939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="PJQL01000119">
        <property type="protein sequence ID" value="RCH99498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBE8"/>
    <dbReference type="STRING" id="86630.A0A367KBE8"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016476629" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="168"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="399"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="474" mass="53210" checksum="76221A45EF866E45" modified="2018-11-07" version="1">MKYLITLILAFAALVQCSTIVARAQEEDVANGSPGAVCYADAYNDLGNNWNHTYAPTEPQQIHMSLADDSKFARVQFATLDSIDSSVLAYWPKKQGNHAQKNTTITGKDWVFVDGGSAQRQLYLHNIQTKTLKPDTIYVYQVGAKKGKTIKWSKTYEFHTASLKKDFSFIATGDIGACNAVAVSHMMKYGKTHKYDFVTIAGDQAYNMADFNGTKGDEYLNFMQELFANVPYLGAVGNHESAYNFSHYKNRFNIVPYAESKFSNSMMYSINYKSLHLVSFSTEIYFEGSEQEIQTGINWLEADLKEANKHRDKRPWIIVMTHHPMYCSANNTDCTTKAATIRNGPGQNNQTWGGIEDILLKYNVDIFLSGHVHNYERTYPVAHGKITSKSYHNAPSFFQLIIGNAGQPEGPALFGNGPFPDFSAVRYEGYGFSTFKVSPTSLEMIHRKANIDGTLGGIIDHFTVTKDIHRHRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KC79</accession>
    <name>A0A367KC79_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_012078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000098">
        <property type="protein sequence ID" value="RCH99815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KC79"/>
    <dbReference type="STRING" id="86630.A0A367KC79"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH99815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="31817" checksum="C1712AF0C3FA668E" modified="2018-11-07" version="1">MCAGNDRFPVTKIDFSKFTNIHYAFAIMTNRSVPAWEDPQKANAQLTKLVTMAHKHKVKVLPSIDWEYPGRQGEGRNEVDEERDVKNFLRLLRELRQAIDGEFGVSKKEISAAVYIRPFNSSVPEMAKVLDRANIMTYDMNGPWNLQAGANAPLYAPCSQDSIDLSVNAWIEAGMPRHKITVGLGFYGRSAIAKVNMLKTKKINRSQVQGQTPQGDKTDVFFQSPFCPLSPGGLSGTWRFHNLLSQHALKSPLEANKPWVRVLDAVTSAPWLFQPKDKGIRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCH8</accession>
    <name>A0A367KCH8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000096">
        <property type="protein sequence ID" value="RCH99840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCH8"/>
    <dbReference type="STRING" id="86630.A0A367KCH8"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="10"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH99840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="814" mass="91493" checksum="D7032DDB3B74F59E" modified="2018-11-07" version="1">MDLSEATQYFDGGIIFVSYIISVIGAQTTLELLTRRTHIHGLYNWFLLASASFTMGAVGIWSMHFIGNNSMTLWADDVSYQLSYEAGCTFASLVVVIVCMFISFTFVGVTEKAQLIRIIPSGIFTGCGIACMHYLGQFAVEYFVIGYRRAYVIGAIIIACIAVTIAIYIFFKLRENWTDTWYKRLGCAMLMAVAVCGMHYTALVGTIFYVPYGHIPPPQPKLRPAALIGIIAAIVVVACATLFYISFKTGLKEFKKVTSKRLILDLVIFDKSGRILVKVDGTLPAKEIVHDLDANEATQHFNSSHPLFILLFEAIIQRVSIQTPFLDNRRHSGVSDTSQPLFDSIKNQFLDAVQDLQQELHFMYPSDLGIMSDIVVTTDTIAKPAFSKVNPFAQKSFKPRQSFQYGNQPLAEIIDETVVDLNVKGKRMSRLVNLMSINKQSEDEELGGNPGRNKRLSSSTALASVDTLRLSVEDSDGEDKHIFLTQRLNNKDTQRLLSQGYRFAEPMFIAKTMAAKLRVPPEYMRQCFLDMDQLINSTYTLTRTPSETKNAVCMGTFVLIEENGLSILVDKVKRYAFPFVDLMLDNEGELDRQELDYINTTLQGRTLLEISQSPKDSWPSPRLAKALEHAANQLFDISAYSKALYQSSVLHSTVIDLPAFALTPCPCQLILFTTLITTPGTETAINHTFYEPFKCIPLSIFKPLCGYLTDQAGYIYQLENRPRPYSMQQQLYLQAGLSEHTQSSDQVEESIESSHRNNFSLPPPPRSKRKRLSTTVVSSQTPLSVLKTPLTVLPTKDRFWWIDLIVENIIHNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KD30</accession>
    <name>A0A367KD30_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000081">
        <property type="protein sequence ID" value="RCI00087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KD30"/>
    <dbReference type="STRING" id="86630.A0A367KD30"/>
    <dbReference type="OrthoDB" id="2277387at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="312" mass="36114" checksum="1F8C18D34DBB631F" modified="2018-11-07" version="1">MKHYMDLEKNGEQMLYDGNSDSIYYNHWAINDYQHIIDNYPVKLCTSYSTPLSRSSSSTTKASSQSMEDSREKNQLLRELYQIKKDIIKFKNELNGLARQMDGMEVDLNVSKNRVQEIEEDITATQEVNVNLQVLLERAVNKQKETDVYATREMKNIHSNLANVVYETGQLRWRLTSIANYQRQQQGNVIDVAERIREYSEMLEEAIQSLQRKPRKSITADTKKSSESHATTPTKTNKPINTVNATTTTTKTTTVTNTTTTTTTTVEKRKKTFVDNNELYKHRIIRKRISNPEMNQAWLPQKGLRILLSDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDD6</accession>
    <name>A0A367KDD6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_015695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000075">
        <property type="protein sequence ID" value="RCI00199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDD6"/>
    <dbReference type="STRING" id="86630.A0A367KDD6"/>
    <dbReference type="OrthoDB" id="63589at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI00199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="791" mass="89436" checksum="CD54C51EA6EE4A5E" modified="2018-11-07" version="1" fragment="single">PILPPSLLPTDFLSTLVTLSQTKLNMYTHLAQFQSCCWKYWDISVPYALFEKKEFDRISPSFLGWWGPAKGVPMLVFVASDVLLPEATPATIKKMQEALQQRIKNIFRATHLIPSRQEPGNSSHAPVDVKSLFLLPSTSQPIIHIIPSIPKPSIETEYTLDEPLPISSYLEQLSVNEPGNLNDEYGDKLLRNFVTIWTKTAVNRHPLHRKMNDAKYVPLPTPIQFASSVVPLLHFLFNQPMRENNENFRDIIIAHYSSTKGMIQQIEVILRKKIKDNIEIERVFSKNYCYNVMQHCQEAYLQDSPPFYPEKYHVWKRDHALRLYASLARGPCKEEYASRLERECDLVWKENRQSCEHLSLTGRSCRLKTGHESISSQSQKRDDRAIMTDSGKHSSGVTFFHACNCGRTQKLRDDPFDIMDANVKFYQRFTCCLGKDRAALDMKASVFGDNQHLELRYDDVPADDSALLLLGPASVYKNNVGLDNVEGFLNNTNYLIPWSITTVNDLKLHQQEQVEKKAKEAITTVLQPVPNQEEWPVLGKAPVAASKTTKAIPAPTAASLEAFPALGTNPPPAPTPVITPEIPVKQLFEAKENSNSRGSSRRRRYNRMRDRLQGLIRGYIGAEYECAQGHRFLSCGEGRVCKIGHAGHPKEHGNYFVHQDLNVFILCPCCYTPSGNGSNAAISSSSEVTAQLMRLYVVTPDEDITISIEPKIKINIPGSDKSIHVNLGIRDPLYLGPGGTYVLRLPFIYRDENGLPIPIETDIERRMTSAVLQKDYIKFHYKKASKWALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDN0</accession>
    <name>A0A367KDN0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HOM3_3</name>
        <name evidence="9" type="ORF">CU097_015573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="PJQL01000067">
        <property type="protein sequence ID" value="RCI00325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDN0"/>
    <dbReference type="STRING" id="86630.A0A367KDN0"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="434"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI00325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="502" mass="55033" checksum="39F84E51E741C4AE" modified="2018-11-07" version="1">MQIELQMNSPQLPWIVQKYGGTSVGKFLNEIADTIIPKYLKTNRVAIVCSARSGVTKEKGTTNRLLRAAKEAITEGSKEHLNIVKEIRNDHINAARSVIKNPEILSVLEDQLEKDCLKLKSFLEAAEIIEEISARSKDIIVGMGEKLSCTIIAAVLKDRGIDSQLVVLSNIINQEFTTLDQSFYDYVADRLKEIIHDCGNRVPVLTGFFGYVPGSLLNSIGRGYTDLCAALAAVGLQSQELQIWKEVDGIFTADPRKINTARLLPIITPEEAAELTYYGSEVIHPFTMEQVIRAEIPIRIKNVENPSGVGSIIFPDSLKRNGSATPPPSPEVLAQNGYHKDLSRKRPAAVTVKDKICVLNIQSNRKNVSHGFLAKIFTILDEHNIVVDLISTSQINVSMALSIDVTENSLSRALVELERLGTVDVIRDMAIVSLVGKQMKNMIGIAGEMFSSVAEAGVSLEMISQGASEINISCVVKEKHALSALKAIHQKLLDADPNLDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDW8</accession>
    <name>A0A367KDW8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000062">
        <property type="protein sequence ID" value="RCI00414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDW8"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI00414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="749" mass="85897" checksum="5C78991146127D04" modified="2018-11-07" version="1">MTYKKKTCEECRNQKRKCNGQSPCERCYKLSLHCAYIVNYSPTDEEFIELAKQGKLLEEVESLKDELAHMEATMSNLRDPNIGNSPAQTLPSLIEDSDRSVSSTDDGCISPLTETDISYSKHPNKRTKRLISFGGDSYVDVSKCNEAKGRPSWTLTVKNGGFCIDTHVNTYSDLYNNLYRVLQVVNSGSRLPPVVTNCVREDTLVGALNEMFRKKYGKVHCKNVARSIQIFITPSIPDVDTMVVVRSPENIKLTTSKLIQAYLRCQHLQQLAIHVPTFFRLFIDAGSSSAVMAFCATVCTLRCKHIVSCLPSVSLVEYGKFYFERARDALSDMFDQCNLETFTTYVFLAVYTSAVGQIEDSKLYTEMAERVATILKPSYSTAYNTKSKSLIHLQKKSEAIHFKRLLNYLHRVETFVEISEAQIAALNSGETRLPFCTLVHSNEGEWQAADDDSVQEKWFIKMHSYILLLQRAVHKASRCAYSSDIYHLVGLIGHQVEMAIFHWYTKVLPREFRLSLPLFDSNVGCEKFYATLERECAHSAVPALTTLAAYEEWVVFCQSYLPKRLPQPENEWKLLKTCWDGGEVKDESRVNKKWIKRIEKLLELRRRINFEGSDQEYLATIEAVIGSSEYHVQKRIVMLGIHASFNTVRLARYLRSRSGDCYFDMRILINAWQLLLTISKVQIMMPPEIIELIPRVHKYLRMCLAIVYDEVKLQPYQGQVSDYVRMMEEEFRSQTVKDDDCDCVSCPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEX5</accession>
    <name>A0A367KEX5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of G-protein signaling</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RGS-4_2</name>
        <name evidence="2" type="ORF">CU097_015652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000041">
        <property type="protein sequence ID" value="RCI00775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEX5"/>
    <dbReference type="STRING" id="86630.A0A367KEX5"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI00775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="205" mass="23488" checksum="A86CE34160FD1A6B" modified="2018-11-07" version="1">MLCSPEPPSLTLEVVLNDPSSDLFKKFANYLRQSYCIENLDFWIAVQEYKECTNDKSLALRCEDMINEYIRPNSPQEINIPCDMREAILDFYQQGNYHPKLFGAAAEAVLELMRVNSFIPWLMLNANSEHWETSTGGIKHSASSTSLSDKLGVKLKQISRKSWSSFDYPSGDSRFLFSVTSYSNNSVCRSMLKKLKRSFSGHQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFS7</accession>
    <name>A0A367KFS7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_015772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000026">
        <property type="protein sequence ID" value="RCI01084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFS7"/>
    <dbReference type="STRING" id="86630.A0A367KFS7"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="30"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI01084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="399" mass="44161" checksum="2087283D2E1144E6" modified="2018-11-07" version="1">MTLQDQLQATLAKRRHISKLRQLVVNPAHAIDFSSNDFLGLSHSLVFREKYLSELSSLPTILGSTGSRLLDGNSAYVEDLEKRIAQFHNSETALIFNSGFDANASLFSTLPQPGDIILYDQLIHASVHEGMRLSRAAKKIPFLHSNVEDFERTLVDVIKQYPGKNVFIALETVYSMDGDVAPLKEIVDILRQYWPNRENGYIIVDEAHGTGVYGTLGRGVVHQLGLEDEIFARLHTFGKALASHGAVVLGSGILREYLINYARPLIYSTFMPFNCLASIKCAYDMLESGQTAPIQAHLHHITQRFRETIKLPIGTLLPSSSPIQGVVLNGNAPVRALAAYLNGKGFIVKPICSPTVPKGQERVRICLHGHNTTEEVDNLVAEIHAFFQISPSQPEEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGG3</accession>
    <name>A0A367KGG3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="9">K(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KHA1_2</name>
        <name evidence="9" type="ORF">CU097_015193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000018">
        <property type="protein sequence ID" value="RCI01259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGG3"/>
    <dbReference type="STRING" id="86630.A0A367KGG3"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="36"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="776" mass="85219" checksum="19C2270DDA368C6A" modified="2018-11-07" version="1">MVGKATPQAGVFTGLNPASFNSSDPIVLFIIQATIILIFCRLISIPLGYIRQPRVISEVIAGIILGPTVMGRIPHFQETIFPSASLPFLNLIATIGLVFFLFQVGLEVDLRVIKRDWHKSVSIAVVSMALPFGLGCAVSVGLYKLQDDPSIPFGSFLLFLGVALSITAFPVLARILAELKLLRTKVGAITMAAGLINDCTAWVLLALVVALLNSSGGLEALYIFLTAVGFSLFLILLIGPLYRKLCVATHSFEQGPSPLLMTVTLLIVLVSAFVTDIIGIHPIFGGFLAGVIIPHEHDLPIKITEKIEDIVNIIFLPLYFTLSGLKTQIGLLNTGAVWGYVVLVIFLACFGKIVGCTLTAKICGMAPRESLTIGFLMNCKGLVELIVLNIGHDAGVLNDQVFVIMVVMALITTFMTTPVVIYLYPEWYQKQTSATIDGNEKVTPLDTMDDEKNSSYISTLTDRYCIVTMLNRIETVPSMMALMQLFNRDKAMSAIEIHTLRLLELTQRTSDVMKFKEIEETARHDPVLNVLKTFASLVGLRSLHTHLDFAQDYIKSIHAYAADVDADIVLLPWAQQRLSLHHEEYAAVDLEFISQALNTISQQCTTGVFVDKGFGLIQEDGDGFMPQIIVVYEMNDEQEKEDSNNCLEFALKIQSSHKANLTVIGTFMKDGMYATRESIKSYKGEIDRLFTSEMKSNIESKHVKELTANNILTAVDRPLSKHDLVLIARHSKQTPSSPLSSSSSQGHSLEISTFGKLGADLLRQGSASLIITQARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KGV0</accession>
    <name>A0A367KGV0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_015909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KGV0"/>
    <dbReference type="STRING" id="86630.A0A367KGV0"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI01398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="444" mass="50515" checksum="6EB165417F31153C" modified="2018-11-07" version="1">MSVFPKDTIKNIGESLGINNLKDEIATALAQDVEYRIHELIQEASKFMRHSKRVKLTVDDVNAALRVKNVEPLYGYTHGETPKFRKATLNSTEIYFDEDEEIDFDSVLNKPLPKIPLDVTFTAHWLAIEGVQPAIPQNPTPNDAKAELLSKRTKTHTSSNGITTDQVNVKPLVKHVLSKELQMYFERITEAILSDNERLQSQAFESLRLDPGLHQLVPYFVQHIHKKVAQNHKNLEILEAMLSMSHALLNNKHLFIEPYLHQLIPPILSCLVGKTICDNPQQQDHWSTRRRAASLVAYICHQYGKSYHTLQPRITKTLLRAFLDPGRPLTTQFGAIIGLDKIGTEVTRVLIVPNIKFYTENILQHALNSTNPLRVEEADRCKQALADVLRHIADQESNENSMEGDISERDKQTFIDFIGSIVGEAYLSAEDRESRIRPILELIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJY6</accession>
    <name>A0A367IJY6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005503">
        <property type="protein sequence ID" value="RCH77980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJY6"/>
    <dbReference type="STRING" id="86630.A0A367IJY6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH77980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="134" mass="15375" checksum="954AFA6DE87B1167" modified="2018-11-07" version="1" fragment="single">VPMVGQKRSMNYNLGLVDYYEPDKRQQFQHSSSSDGSTSHTSRAREIGFLDNTEDAALMYDIFMVDNPPFYEDKKDELLYQTKLPLPQPTKQASVLKTSWAAPSAPTQRPWSKFFLESEVQTLHYQTSSLVNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IKC0</accession>
    <name>A0A367IKC0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ACBP1</name>
        <name evidence="4" type="ORF">CU097_000688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005406">
        <property type="protein sequence ID" value="RCH78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IKC0"/>
    <dbReference type="STRING" id="86630.A0A367IKC0"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="51" mass="5636" checksum="0DF2F06CB455EDE3" modified="2018-11-07" version="1" fragment="single">MPSKEFETAAEEVKQLSKSPSNDKLLELYGLYKQATVGDNTTSKPTFDLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMI3</accession>
    <name>A0A367IMI3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004855">
        <property type="protein sequence ID" value="RCH78879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMI3"/>
    <dbReference type="OrthoDB" id="10489856at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH78879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="54" mass="6285" checksum="61F066C27C4B3CC0" modified="2018-11-07" version="1" fragment="single">NTDKSNRLQSMVHFHVERAKSLIFRNNKSPSESVIIVNGLLRFISRLTKHHLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMU8</accession>
    <name>A0A367IMU8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_000225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004760">
        <property type="protein sequence ID" value="RCH79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMU8"/>
    <dbReference type="STRING" id="86630.A0A367IMU8"/>
    <dbReference type="OrthoDB" id="2290219at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="342" mass="37597" checksum="A98D867D4319EDDD" modified="2018-11-07" version="1" fragment="single">ITDMSAGDALDRFVRGLKPDLRVMVRSRFPHSLESAESMALAIEAARNDGEPVSVPIVANPNPFARGGNSASHVRDDPMDLDAIRQALNVISSAFNNGRNGRSGDRRNGNRRQVRCYACQGMGHVKAECPTWKRSAGPKKSFGGNNGGPRQRSLNSIQHVASASTGGSFAVEEDGNDIDVDSNFLDQDHAHLLNLNNKETDLPLYEFVLCYDDNKCRKVKVLLDTGASANYISPRLLDGKMKVLPLRSCREVETAGGHITKIDQKVDFKLCAQQLSYRVQAYVFDMKFDIILGQQWFQQAKPIPQWSTSSWVLPVGTRGTVTLSPCDNSLNQDSINGAQDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367INF7</accession>
    <name>A0A367INF7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004637">
        <property type="protein sequence ID" value="RCH79214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367INF7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH79214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="70" mass="7795" checksum="F8F7C2099C22B928" modified="2018-11-07" version="1">MAAAFGQTQGLMNAAALQQFQMNLQFQKQQAAAAANAVQQRNSLLHFQQQQQQQQQQQPPNNNNSVDNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IT19</accession>
    <name>A0A367IT19_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lanosterol synthase (Oxidosqualene--lanosterol cyclase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ERG7_1</name>
        <name evidence="5" type="ORF">CU097_003784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003740">
        <property type="protein sequence ID" value="RCH80779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IT19"/>
    <dbReference type="STRING" id="86630.A0A367IT19"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH80779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="350" mass="40335" checksum="CBECCE6D54CBAB9A" modified="2018-11-07" version="1" fragment="single">MGILPEDFPSAKLNLTTNPQFTDLTHWRLNVDEGSQIWQYLETEQERQARPQSICEKYHLGLPIVNRKQHHDVPELEKAKSPLEAARNGFEFYRRLQTEDGHWAGEYGGPMFLLPGLIIAHYVTRTPVHEPTRLEIIRYLLNKASKEDGGWGIHIEGVSTVFGTALNYVTLRILGLGPDHPAMVKARNTLHRHGGAAAIPAWGKFWLAVLGVYDWNGVNPIPPELWALPKFVPLYPGNWWVHCRYVYLSMGYIYGHRVTAPLTTFTQSLREELYVQPYDTINWDKQRNNVAEVDLYMPHTKIMDVVNYALTYYESFAKKFTALRDYGLKEAVEQIRMEDENTYYMGIGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITI3</accession>
    <name>A0A367ITI3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_003914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="PJQL01003657">
        <property type="protein sequence ID" value="RCH80946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITI3"/>
    <dbReference type="STRING" id="86630.A0A367ITI3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16667">
        <property type="entry name" value="RING-H2_RNF126-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH80946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="354" mass="39268" checksum="5167245CF4B69483" modified="2018-11-07" version="1" fragment="single">LQADDDPREFLSGDNHQHNHESDADHTSTRTFRRQIFLPDGGSAQLFSISHGNRGEAGDDIYQFFTPRNEASNEQQEQPEPSINNIVQALLANLMNQAHTESNNTNNNNNNNESSQESTTDNPQTATGNNESGSGSGNRPFVFYGNMVNGSIRFQPFSPINSNNQEQQQQSQQGDEQNNNNNDTRGNVASSILQFITAMTGGALGEEIVGNPNDYVFSRTAFDNIITQLMEQAGGGSAPPPAPEQVIETLPKRGLTEKEKSQEADCAVCKDAFEATEQVIQLPCEHIFHDDCIKPWLKLNSTCPVCRHSVLPDQQEHSQQSDLNNREQGQQGNNEEHLREQQHSSQHPDDIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUC0</accession>
    <name>A0A367IUC0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_001785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003529">
        <property type="protein sequence ID" value="RCH81219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUC0"/>
    <dbReference type="STRING" id="86630.A0A367IUC0"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH81219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="57" mass="6290" checksum="19C9E3B2E0FDED04" modified="2018-11-07" version="1" fragment="single">QKLHNAPRPKTLKPHNARKESKDDEGSQLVCSNCSTTTTPLWRRDDEGAPLCNACGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IUQ6</accession>
    <name>A0A367IUQ6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_003062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003449">
        <property type="protein sequence ID" value="RCH81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IUQ6"/>
    <dbReference type="STRING" id="86630.A0A367IUQ6"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="82"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="431" mass="48446" checksum="FA77AFC92DE28F8E" modified="2018-11-07" version="1">MVYPSRKVEPYIKTVCKECSVQLEFLPEPGIKNLKVKVECWSCHKTSNYDIDASGTKVNNNKTNPRWSTKKRGTDENPASTEYYDVLGVSPSATDAEIKKAYRKMAVKYHPDKNPNNPSAEDTFKKISEAYQVLSDPVLRKRYNEYGEENGVKPDGGFADPEEFFKQAFGGERFVDLVGEISIGRQMKEVMELHDDTKKTPEQKAEMEEKKKKLEEARAAERKARVDKLVTRLISKLSLYTELNDISEEARSAAFSNIVQIEAEGLKHEGHGVELLHTIGNTYLTKATQYLNKSVAFGLGGVFHSMKEKGYIISETVDTLRTVINLQSTFAELQKAEQNESLTEDEIHRLTAETTTKGLEALWKGSKLEIESVLREVCDKVLSDPTVSKETLKNRALGLRIMGSIYSKVKADVTPEDIPIPIDPSPTKSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IVM9</accession>
    <name>A0A367IVM9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003306">
        <property type="protein sequence ID" value="RCH81734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IVM9"/>
    <dbReference type="STRING" id="86630.A0A367IVM9"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="175"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="573" mass="66013" checksum="1FE5CBBEE7D47265" modified="2018-11-07" version="1" fragment="single">MKENGSFISFSTFGSDQNNVQVYAENYINVERTLRSLNYLASHVFQVSIQFSVPQSKEAIGHLLKDLTSHAIYHNNRLIMTGSKEQIQSCIQYISKLSFLQEHHESTTFYIELAVDQREFISGKKNGKINKIMKTCDTQIDFDSFNQFNFLITIASNDFSKAQNGFDSLQEELPAEISFYVPESCHRRIIGVAGKNIQRVMKQYGVYVKFSSHEELATFGGYFENEHNVIARTPQKNKDSLQLLKSAIMNFITLQKDRDHTAEKEFVPYYAQRYLLHFSGKYLREKGRLYNIKVVWPERNGTDHVLIVGPKAHINDMRLRIQSLLPQQIQIRVPASVALERILESEEIEELDSKIFKKTGIYLILPEHIVPLKETTSSFLIIEGGQGQLSALDSRVLTFKFCFDYNTKHQLQQARAMFDAFMGSRFVPLDDTLHNVLNGSPDPEDMRHISPSVMHLIDHPESYEHTRRKIVNENHKLFQPWGNAQKSNNGFHMNDYTPFTMNHYSRQRSTSLLPTSSSNGNKYYPSGDYYVPLLGKIPSSSLSTPIPHHHHNNQANPLLLNMHQQQQQGRFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IWR3</accession>
    <name>A0A367IWR3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA carboxyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_004701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003143">
        <property type="protein sequence ID" value="RCH82117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IWR3"/>
    <dbReference type="STRING" id="86630.A0A367IWR3"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="294"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="552" mass="60913" checksum="A63ECAA35EE4A866" modified="2018-11-07" version="1">MTNKVKNRIEQITQHLNSKKDEALEKSEWKDTILEIKKRQYLNQIADPDDRGYIRQKTTGKLWVRERIDLFLDKGSFREIGSIAGNARYSKDGSLQSYTGANFVAGKGTVAGRDVIVGADDFAIRGGHADGAVWGKSLFAEQLARKLKIPMVRLIDGSSGGGSVTLVLDKGATYLPPLFGMHDMIASLSEIPVVAAALGPAVGLGAARATLTHFSVVSKDIGSLFAAGPPIVENATFENVSKESLGGALIHTANGTFDNLAESEQDCYNQIHQFLSYLPSNTGQLPPVETAHDPVDRRDDELLSIIPKRRQRVYQVREILMRVLDKSSWFEIGSRWGDGAVCGLGRLGGYVVGIITFDCTLKGSVISAASCQKFRRHIDLCDTFGIPIINFADYAGFAVGTKAEKEATIRHGSTLTAALYQCDVPYFSVVLRKVFGVAGAAFVDNRVPNMRIAWPSGDWGSLPLEGGIYAAYRHELEAAGDKRHELYEKIMAQFESVRSPIRTAEIFDMPEIIDPRDTRPILCEWVKLVYDHILPQRLERIKIQGPRILYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXI9</accession>
    <name>A0A367IXI9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003028">
        <property type="protein sequence ID" value="RCH82398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXI9"/>
    <dbReference type="STRING" id="86630.A0A367IXI9"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="142"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="315" mass="36522" checksum="0A7A5FBA7E7A956C" modified="2018-11-07" version="1">MNLFKFNNNNNNTKSSAASTKSSVTATTVDLGPMTQEPILTPPTDYQPVLNNPLDEEQKKKVDALMEYVESIMLPKEHEYYPNERGFLTEATAKRYLRARKWDLEAAKTMLENSIKWRREFRPDQLDPEMIRPEAETGKMYYNGYDKTGKPLWIMKPRNENSKDSDRQIRHVVFNLERGIRLMPPQVEKVSIVVDFKGSSITSNPSASTCKKFIDILANHYPERLGVAFFVNSPWFFLTTFKMVAPFMDPVTRNKIKFIDEDTNKNSQDVICMEDCISSEQIEASLGGKFNFNFDIDTYWDALLKRTDKEVIEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXJ1</accession>
    <name>A0A367IXJ1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003015">
        <property type="protein sequence ID" value="RCH82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXJ1"/>
    <dbReference type="STRING" id="86630.A0A367IXJ1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="322" mass="36701" checksum="1DC71E48CBDDEEF4" modified="2018-11-07" version="1">MRGLGRLSFSFFATFVMEDSKSHIRSLYTICLEYIVNHNESLTALDHVPFHPFASDIIHGIFQSKKQLEKTTLSIFGKTYGQYLLRHTPPEWTSIQFSYFKLAGSSTIVLGFISQHFPMFVTRLDMSYTDIQDKHISLLNGFKHLSVLNLRGARLLSDSAVSDLSAMVIHKGLPALEEISLSDIPSITDKSLKHIGKMESLCYIDLTSTSVTGQVADMYLIKLGFTKTDEKRHLQQPSPCIKLHQDILDMVLASTDFVRGTNMPIKPSTSLSRNLCYKRAQAHVKQVQKRKLSYDDNKRKKVRNELNLDIYFDSIVNEFLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXN1</accession>
    <name>A0A367IXN1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003003">
        <property type="protein sequence ID" value="RCH82473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXN1"/>
    <dbReference type="OrthoDB" id="2402731at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="112" mass="13212" checksum="487F936D11B373EA" modified="2018-11-07" version="1" fragment="single">MKSNYRQISINDKAFVDVCRCLYQAKAIVRDLQSFSNTVCPALTQYSKLLNNEKLNDRTNSDILLKQVKEYLNTTFRKFTRLCKMLLYILTQMEENSAGQVKRERIDSFRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IYT7</accession>
    <name>A0A367IYT7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002868">
        <property type="protein sequence ID" value="RCH82855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IYT7"/>
    <dbReference type="OrthoDB" id="2258775at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH82855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8495" checksum="3AC76AF6514631F5" modified="2018-11-07" version="1">MSEPTTSANTMSEIPMTPLAAPAPVYPASENMMTTQQNQACSGEQEQQDQRSILRLRGGGCITDCLAAIGCCCICEECCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J0P4</accession>
    <name>A0A367J0P4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GABA-specific high-affinity permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002635">
        <property type="protein sequence ID" value="RCH83512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J0P4"/>
    <dbReference type="STRING" id="86630.A0A367J0P4"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH83512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53257" checksum="950328DB2D4EFB51" modified="2018-11-07" version="1">MNEFNKASYGAVNDPKMVLQHGKKQELQRTLSAFATFGLAFSNIGILSNTSATFQTVLQRGGPVTMLLCWNIAAVFMICVALSLAETCSMYPESGGLYYWVFELVHNRSNSKTKAATSAFVTGWSYYFGNIIATSANNVTVGKDMVGVTLKSNNIKIALSIGSILNLLTGVHLDKVLIMMIALVVTGLHAYLNIRSLHCLSIINQWNVFWSIAGLTIIIAALSIFAPHQNSMWVFTHYENGTGFDNTFYVFVLAMIGPAYSLFGCECAASVNEETQDADISSPIAIVGSIATAWAVGLVFLIVLLFSIQNMDSILNTSFDMPVAQLFQDAIGTWGTLGFLMMVVICQFCTGATTMTVASRQVYALARDNAAPMSPCLKYINAYRLPENAVALTFALICLITLPFPLSAHLFETIVSATTITIHFSYAMVLGCRLLDSGKKKGRFHLGKWSYFINVLAFTWTAFAVCAFMLPTSWPITCKYKSKRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J103</accession>
    <name>A0A367J103_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone deacetylase complex subunit sap18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002614">
        <property type="protein sequence ID" value="RCH83590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J103"/>
    <dbReference type="STRING" id="86630.A0A367J103"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH83590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20144" checksum="096DB8C09149C2EB" modified="2018-11-07" version="1">MSNVDREKVCPFLLRIFTRKGAHNQLSAYTVNEVPQDELAIYTWKNATLEEIAQLIEQVVPDARDPDARISFRLVYLDQHRGKYFARDIGRVVSAKPTKEQKKTLEECKFVIGDYLDVAVFIGPPPSVMRDQRSRGRDFGRFSSGRPPRRSFDRGYSNNNNNNSRFGGRPRRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1J3</accession>
    <name>A0A367J1J3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ESCRT-0 subunit protein hse1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HSE1_1</name>
        <name evidence="10" type="ORF">CU097_000130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002616">
        <property type="protein sequence ID" value="RCH83581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1J3"/>
    <dbReference type="STRING" id="86630.A0A367J1J3"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH83581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="437" mass="49529" checksum="7DCC58DF92312939" modified="2018-11-07" version="1" fragment="single">YHSLRAEGVPFPSPQKPKKEFTQSELDKQKEEEELQLALALSLSESENNKRAGFKSSTTVATATTTTTTSTTNNTQSANTNKNDNQPQISRVRALYDFQPTEQGELGFEKGDIIRVIESVYRDWWKGELRGRTGIFPVNYVEKIIDPSPSDIQKEASIENEVLNQTSNIDRLLELLTNPDPRLRDSFSDNDELQSLYNNALSIRPKLVKLIEKYSLKKDELVALNEKFIQARRMYDTMLSNSLARYSNVQSSYGYPPTGQPFSYEPQYYNYQSFAPPSQPQSFNYQSSAPQPPTPVQSNATPVQAPAGYYNEPVHQSPTTIVPPSQQLLQQPQQQSIGENQYQSAYDQNKQPPSQQQHSEFSALYQNIPEQTSSQAPPLQQQQPSQSPLQQQQQQQQPQQPFAPYPPYQSPMSFPNANPAAPIYPGQQQQQAYTNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2A9</accession>
    <name>A0A367J2A9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PAP1_2</name>
        <name evidence="20" type="ORF">CU097_006808</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01002470">
        <property type="protein sequence ID" value="RCH84073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2A9"/>
    <dbReference type="STRING" id="86630.A0A367J2A9"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="19">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="18">
        <location>
            <begin position="208"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="17">
        <location>
            <begin position="355"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCH84073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="559" mass="63455" checksum="2EE49753C386059A" modified="2018-11-07" version="1" fragment="single">MSQEKPIQYGVTAPISTDPPTEHELKLTEDLLETLKSYGLFESEQEAQKRVVVLGKLNKLVKEFVYKVSKMKGFPDSLAREAGGKIFTYGSYRLGVHGAGADIDTLCVFPKHVQREDFFTIMYDMLKERPEVTEISAVPDAYVPVIKMHFSGIPIDFICARLAVARVPDNLELADNNILKNLDERCVRSLNGSRVTDDILRLVPNVNTFRIALRTIKLWAKSKAIYSNVMGFLGGVAWAMLTARICQLYPNACAASIVNRFFLIMYQWKWPQPVLLRPLEDGPLQVRVWNPKLYPADRSHRMPIITPAYPSMCATHNVTESTRKIMIQEFKNGIDIASNIIFGTGKWSDLFVKSDFFHQYKHYLQITSASHSSEAQLMWSGLVEAKLRQLVLKLEVVDMIELAHPYVKGFDKVHYCLTEKEVEDAMKGVLLKDRSISVEEGSLETDHTELLKEKKVITEDDVKNIKKVYTTTFYIGLEISKPKVGGENNDNSETAAADSGRKLNLVWPAQEFQKVVKAWDKYDEEQMKISITTIKRSKLPSELTTQDDSKKTTISSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2J5</accession>
    <name>A0A367J2J5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exosome component 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EXOSC5_1</name>
        <name evidence="8" type="ORF">CU097_007070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002446">
        <property type="protein sequence ID" value="RCH84155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2J5"/>
    <dbReference type="STRING" id="86630.A0A367J2J5"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH84155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="24676" checksum="E8C9F43FB510BDB6" modified="2018-11-07" version="1">MTRPDRRTENTQLRTFSATQNVLHRADGSARFDLGATSVICSVSGPMEVPLRDEKLDEATVEVVVRPSSGIASTKEKLIENTLRTTFEPIILGGMMPRTLVQIVVQIIKDDGSVIAAAVNAIALALLDAGIPLKYMAASVTCMIDKTNNIILDPTAAELDNAKSVHTFAFDNTPRTTTVLLSDSSGVFSEEEYIECYDLCHQAVGQVHSFIRTAVEAKKQKEHQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3Z3</accession>
    <name>A0A367J3Z3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002334">
        <property type="protein sequence ID" value="RCH84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3Z3"/>
    <dbReference type="STRING" id="86630.A0A367J3Z3"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="466" mass="54551" checksum="94A87969D30F2CFF" modified="2018-11-07" version="1">MLHNLMAENDALKPSACFQKMCQVMMNEGLNKQQVEDFRLILHMLLLESSRHNIEAGKTWILEKCTSPNQVSALMEYLLSLSRSTTAREERLHLIYLLNDVLYHASRRKLFWIRDTIFPLLVPLLKLAYEAAETDEHRAKVTKCITFWSDRDIFDEASIAYMRQVIVQPALISQPAIPNVPNDSPSLPPKVQMVSPSKPYYELPAGLMTLVQHHVYYKPINPSTIKVPFPPPEPTKEVLDAIQEFYSGLDLLTKEVDPIFDDKVSQIIDPQGWQKGYLDNYYEKTIAQRKEWEEKQRQKEEEAERDRRRHSDHRTKRSRSRGRSPTYRSRSRDYHRSRSPSYSSYDSRGRSRSYTRRKRSRSRTRYRSRSPYRSLSRRHRHYSRSPPPSYHHRSPQQHHHKPVPTPVVPVVPTSSFNVPPPPPKHLGLGNQTMDEFAAFRRNKSESYSRREPPPPLICYKCGKVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4J0</accession>
    <name>A0A367J4J0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002248">
        <property type="protein sequence ID" value="RCH84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4J0"/>
    <dbReference type="STRING" id="86630.A0A367J4J0"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="232" mass="27032" checksum="D489692B3382846B" modified="2018-11-07" version="1" fragment="single">MKFGKQIETAAYELPEDWRPYLIHYKILKKLIRLVVDELESRGLSTKWISTLDTREAMKLDYSLDGNVENPHPCIKITVDDPTSIPPSGEPILLKLIPETQPISTQPLSIKIELVRDSEFFHRLLHELSHAAALYDTEKRRFLGNINDLEDQLTIAASPHKNDLYVWREIFHLYVEAAIFKDMCDKQESYKRSQEQLQWFTEELSRMNLANKLSSKRSRAALTMFLSINTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4L6</accession>
    <name>A0A367J4L6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002246">
        <property type="protein sequence ID" value="RCH84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4L6"/>
    <dbReference type="STRING" id="86630.A0A367J4L6"/>
    <dbReference type="OrthoDB" id="416752at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17769">
        <property type="entry name" value="NP_TgUP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF14">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="313" mass="34367" checksum="B51338FF37F55B0B" modified="2018-11-07" version="1">MKETIVGANFPRDAEGRVYHIGVKQGDVANRILTVGDHVRAKRIAQLLDSEEEAGHPVFEKLSQRGFLTITGRYKGVPVSIIAIGMGNSMMDFFVRETRASTEGTLAIVRFGSCGSLSHQAPAGAVIIPKAGFCIRRNLDYFSKEPLYPELKDKPYLFSGTFPADEEMTQLLSKQIKDALAPIEKDGLLVGPVLSDGLNADGCSFYASQGRTDSNFWDDNEGVLQEILSIYPETHSIEMETSMLFHLANCASKPIRAAGCMQVFADRIANNFIRPEIVAVLEPAVGRACLEALIKVQIEDEMDPVGTVWEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4S4</accession>
    <name>A0A367J4S4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_006509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002250">
        <property type="protein sequence ID" value="RCH84849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4S4"/>
    <dbReference type="STRING" id="86630.A0A367J4S4"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016950313" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="19063" checksum="784925800C972EE3" modified="2018-11-07" version="1">MFHRSFTLILVTVAVILATLLHTADAASRSSVKNILKVTNSLRAKHHAPPLKWSNKLATYAQNWSNRCVFEHSHGQYGENLAYGYPNWGSVIRAWYSEVKDYDYDHPQFNAGHFTQLVWKETSEVGCGAKVCNNLCPGCKLYTCSYKVPGNMMGDNWRYFKQNVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J6A1</accession>
    <name>A0A367J6A1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002086">
        <property type="protein sequence ID" value="RCH85484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J6A1"/>
    <dbReference type="STRING" id="86630.A0A367J6A1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23454">
        <property type="entry name" value="beta-trefoil_Ricin_GllA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH85484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="323" mass="36603" checksum="099EC4D3AC9B35BF" modified="2018-11-07" version="1">MHGFPDGQYFFIKSQANGQVMDVYMGETTDDSNIIIWPQKAGDDNDNQLWRAEDGFLINKRSGLVMDVRGGDLKSDTAIVQYSRKMTMSHNQRFGYRDGFVYCLADPRLVMDIRGGGNKEGTRIILYKRKDSDNHNQKWTIVPVGEPQHGDGQVPYYPPPDYPQQQQQQQGYPQYPQQQQSPGYPQYPQQQQGQNYPYYPPPSGQSYGYGQPDNQYGGSPYPSYEDASRAHNEVYNEGRKAHLSHQLIAGAAAFEAVKAYARHQARQGEPMSHAFIKQSVAALAAAEVVKLAEEHNWSGDQKEKATREAQEAAEKYASREFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J7J1</accession>
    <name>A0A367J7J1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrator complex subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">INTS9_1</name>
        <name evidence="7" type="ORF">CU097_006825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001984">
        <property type="protein sequence ID" value="RCH85917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J7J1"/>
    <dbReference type="STRING" id="86630.A0A367J7J1"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="302"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH85917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="643" mass="73113" checksum="54AE5CE5820BAE2D" modified="2018-11-07" version="1">MKIQCIGNNVFICRTRQLKILFNCSLETKTLNKQQQEQQQQETRSDLSFILSRYFSEQGKRATDTQYSSVTSAINNCDEQTVFRIPDFRLIDIHTIDLVVIANSECMLGLPYLTEYMGYKGKIIATEPTIEFAKQRMEELVIYHSQNISYIDPGSSRYLTQLLPSSSIPEGWRSIYTLRDIESCIEKIQPVRYNESLLLFSTLRLVAHSSGYCLGSANWLLETSFKKIVFLSTTSNFNHLHPAPFDQTVLADADAVIVADVVEPSSNHISFDRAMTKLLAHTARTLRSNHNVLIASPSMNILFDLIGMIQTYLKSIGGKEIGPDRHDIPMYVVSPIADKSLKYANICGEWMNLDRQSLLYEPHMPLPHGQLMKTGALKVIPSLDSTVKPEIREPCIVFAGDPTCIHKGSIVWFMNQWKSSKDNTCLTIVPEAPITDEIKPRDCEMTCVHTPLDTRLKLEDIPSILRVKQPLKDTRYLLIPKMKGADLVKEELSNDLKTKVYIYTIGDIIHIDLKREWEEITVSEKLAKSIIPTHRQVNGHHVSLYAPINGILNVYNNNLELHPDMSNLRDNGQALRIQVELNTIIQQFKQNSIPIEIKSSQDGEITIELPSDLDSRVHIRQDSVTIVSDDERVRSLLKSIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J826</accession>
    <name>A0A367J826_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001950">
        <property type="protein sequence ID" value="RCH86055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J826"/>
    <dbReference type="OrthoDB" id="2289047at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="152" mass="17431" checksum="D229CB0AFF4783F4" modified="2018-11-07" version="1" fragment="single">MSSSHINDIHNNQIVNIYQTDKRLNCEDSSSESSQSEPDVKRKKTLNYFHGKRIKSWEPVTALIVDDLDITEILKKFRDKNIRIAEASNHLSSVRLLSVSHIFPVSKLSQDNCLTNYMKSEIDIALKQFAYKDLCLSKVSAKSLIYVKDILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8N1</accession>
    <name>A0A367J8N1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_000891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001903">
        <property type="protein sequence ID" value="RCH86276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8N1"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016596738" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH86276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="76" mass="8332" checksum="037991774B3B5D31" modified="2018-11-07" version="1" fragment="single">MVSANYIFSLLVLTPLLVQAQPTKTSSAPLAKRSPHDCFSSGHWGYIRDVLSSCSQATVDLSNQLVGRNYAAQRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J948</accession>
    <name>A0A367J948_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_009730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001861">
        <property type="protein sequence ID" value="RCH86463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J948"/>
    <dbReference type="STRING" id="86630.A0A367J948"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="422" mass="49266" checksum="FD3A88FD44EDAAA2" modified="2018-11-07" version="1">MRHDRALCPNAPDLAGYYYDRAREELMEYFDAPASCALIEAIINLSMSCLICKRYSKTQIYLDLGYRKWLELGASRSQYRMDIMMRKRYLKLGLALRYNDYLNNYDSGEPCIIDDSDHNVDYNEINVLNDKILKGIKCKQDIMRFEQTRIREAYYVYHVELIKIGKQTTKLALCGASEKVLLARERSLIDWYERLPDNFVNHVESPSSAYASIERQASLLLKMEYERQWINIHKHIFKNINVNDDIHSQRAKSKIQCIKSAVAIVELAELYNEQFEWCVFQFFLTCIYQASTVFCMIALEKTGEQAQCKSMILRVMRILGVASRKYEGMPDGMARCLCEFLKNQNLHDDLECACNTYLKLKPNPIQEEKEEQKEQEQAQVQSLLQQDLLPDPQTTLANDEELRALGFDSELKELKQMLSTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9D0</accession>
    <name>A0A367J9D0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Williams Beuren syndrome chromosome region 22 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_003671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001886">
        <property type="protein sequence ID" value="RCH86351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9D0"/>
    <dbReference type="STRING" id="86630.A0A367J9D0"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="199"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH86351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32155" checksum="3F8EFD8848DD4AF1" modified="2018-11-07" version="1">MSRPEHIAPPEIFYGEDEARKYTDNSRITAIQAEMAYRALELLNLSEGPKYLLDIGCGSGLSGEILEEEGHIWVGMDISSAMLDVANEREVEGDLFLQDAGQGMGFRPGVFDGAISISVLQWLCNADKTINRPKARLQRFFSTLYASLNKGARAIFQFYPENDDQIELIIDVATKCGFEGGLLVDYPNSKKAKKYYLCLFAGQQSGVKNQMPKALGEDGELHPDEAQSIQYEKRRQQTRRRRGDRKSVKTKDWINNKKKIAREKGDKVVANDSKYTGRKRKIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9P1</accession>
    <name>A0A367J9P1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001823">
        <property type="protein sequence ID" value="RCH86648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9P1"/>
    <dbReference type="OrthoDB" id="2359716at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH86648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="75" mass="8313" checksum="534C3ED3D8DA7CED" modified="2018-11-07" version="1" fragment="single">SAVLLLAGTTVYYMVNVGMLVNRRMELKKQGKLQEELARLNGLMDQQNDRILHAETSTTPTPLPDTDTPGTVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAM7</accession>
    <name>A0A367JAM7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal-coenzyme A synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_005848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001774">
        <property type="protein sequence ID" value="RCH86889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAM7"/>
    <dbReference type="STRING" id="86630.A0A367JAM7"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="428"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH86889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58500" checksum="7E35B9933E77770E" modified="2018-11-07" version="1">MTSDTLYSIFEQRKDARKPAIIIPKSAPVPTTITYHQLLDIIHDFSNKLSNLVPASYLEPGRSISISYPNSLEFVVAFLGSTFMNLIASPLNPAYTEDEFNFYLEDAKSSVLVLPKGTLNQEKNPAILAAKKQGVFVVEMHWNGSQMEINAHAPSEFSQQPHRQIHSFNPKPDEPALLLHTSGTTGRPKGVPLTHLNLVTSMRNIINTYELNTQDRTLLVMPLFHVHGLICGLLSTLLSGGTAVIPQRFSASHFWPDFKDNHCNWYTAVPTIHQILLRNPPKEVPPIRFIRSCSSSLAPSTLEALEKHFKAPVLEAYAMTEASHQMTSNPLPHRGPHKPGSVGLGQGVEVVILDEQGNPAELGEVCIRGKNVTKGYLNNPEATASSFTKDGYFRTGDQGKKDKDGYLILTGRIKELINRGGEKISPIELDGVLLSHPKVAEAVSFGVPDEMYGQEVHATVVLKAGVKDDEKSIERELQAYCQSKLAKFKVPKRIYVTDIMPKTATGKIQRRKMVDVFFKGPVKPQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JD85</accession>
    <name>A0A367JD85_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCR4-Not complex component Not1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001574">
        <property type="protein sequence ID" value="RCH87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JD85"/>
    <dbReference type="STRING" id="86630.A0A367JD85"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="2">
        <location>
            <begin position="112"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="1">
        <location>
            <begin position="475"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="1">
        <location>
            <begin position="655"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="88649" checksum="D934A286182BF23C" modified="2018-11-07" version="1" fragment="single">DEILLNAYASRKKHREQQQQRGNPQPYFDMDIFSVSRFPATLPEPLRPKPNGIHANQLRIYEDFLRVPRLAPQAPAGQMLHSGYNTGLISLLEQQQVSAHQILERFAQYISDLEKLISVTNVPSFGHLPLQHDIITIIHQIPLLALSSFDKAEAARTFAQKVVQLLYKSETQLGREVYVVLLERLCEVSPNVGVLVTSWLTHADDERKYNVPVTVALIKANLINLPEQDQELATLIDSGRMSAIDFTARLIRACLYEEGGLATRQDFMASLEALSRLRGNVPESVLFLMEEMRRRSVPGSTAAPVTLQQHPMLPQGLSDEEVAIREQMHVLFSEWIRLYQHPTSTDKILKVFVTQLSQQNIFKMEDMSSLFYRTCIEASVEHAIKHKQLLNQPVGLTYLPIDALSKLIVCLVELPQPPVDNSAMGKAAMDSPDSARIALFTKILSIVILVISQMHDQRQQQFDQRPFLRFFTSLLCELHSSEQQLQTVYMSILSALSNTFNTLQPLNFPGFTFAWLQLTSHRMFMPKLLLAENQKGWPIFQQLLISLFKFLNPFLHKAKLKDTTRMLYRGTLRVLLVLLHDFPEFLCDYHYSLCDVIPSSCIQLRNLILSAFPRHMRLPDPFTPNLKVDLLPDINQSPNILSDYTITEGIPVNQGAPIQIFQYLLNELDSEGRYLFLSATANQLRYPNSHTHYFSCVILYLFAESTKEIVKEQITRVLLERLIVNRPHPWGLLITFIELIKNPRYSFWNHSFTRCATDIERLFESVSRSINQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEE1</accession>
    <name>A0A367JEE1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001494">
        <property type="protein sequence ID" value="RCH88290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEE1"/>
    <dbReference type="OrthoDB" id="2289025at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH88290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="476" mass="53606" checksum="F8692947E0A74971" modified="2018-11-07" version="1">MNEHVSHVLVGETNVMRTNAGFPCPDCASVFKDAKGFSRHILKQHNLKCKPIADPKSSRFTVQESPILSTSASSDSIADSFTDTDTDTFTDTNISTDTVGSSSVYSFEFPPPAANDRFIFMNMDISECFHNFQLAVKAKINQDPMSLTLEEHVQHILALSGILLLKPARTHADLHQHIDLDICDRLLDHILTSHLITRRHVFPSDIKDSVGEIVKRIVDLEPLDLPTYTEPYTRMYASREIMKLMEGVTLSQTNRILLVIRNMVECLPRHIIGDGPQEIELVTRNLQSVLVPLFEDIDAGIIFRWTSVSDDEKGITTRPDASINIVRGASLGQRLGCGEVKPQYQALNHKAIAKDLIRVGHLAKDASDKYQTRMIFGFVVVGNHGTFYVLHRTQEHLYLMCEIEHVQLPVVLGEIPLFLAQLDKVMNIVAGFAQAARREHHTYDHHPFTLADHKLLAIIDPKTSRKRKSITSHYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JEX0</accession>
    <name>A0A367JEX0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">AGC1_1</name>
        <name evidence="16" type="ORF">CU097_000777</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001470">
        <property type="protein sequence ID" value="RCH88419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JEX0"/>
    <dbReference type="STRING" id="86630.A0A367JEX0"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="133"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCH88419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="279" mass="30525" checksum="DB1F0D46E00F569E" modified="2018-11-07" version="1" fragment="single">GLGPQLVGVAPEKAIKLTVNDFVRYQFTSHQNGEIKFWQEMVGGGAAGASQVVFTNPLEIVKIRLQVQGEQAKSMPDAPRRSALWIVKHLGVVGLYKGVAACLLRDVPFSAIYFPAYAHLKKDVFKEGPDHKLTISELLLSGAIAGMPAAYFTTPADVIKTRLQVEARKGQTTYNGIMDAARKIYAEEGFKAFFKGGPARIFRSSPQFGVTLTAYELLHQLFPLPGHGAAGTAAPSPQKAASQLEAAEQRQMFRSTNALKMLLDLDYRFGVYQLPKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JFM0</accession>
    <name>A0A367JFM0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_000458</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001450">
        <property type="protein sequence ID" value="RCH88531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JFM0"/>
    <dbReference type="STRING" id="86630.A0A367JFM0"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH88531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="182" mass="21489" checksum="79832EC21EFDF7CF" modified="2018-11-07" version="1">MLSFALHSPQMEKAMYALKIVFGFIFVLFIDTINRLQRIEAEADAEQQHHHDYNYETSLKAKKFYSQRNLYLTGFTLFLSLILERTSALVLELAKREEELKSAKNQTAEITKGQKRLIDMEDDYKKQVEVLNVQIRELKRQNLDYDTLKKQADQQQKEFDRLATEYNKLESTLKEGESKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGL3</accession>
    <name>A0A367JGL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CU097_006436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="PJQL01001349">
        <property type="protein sequence ID" value="RCH89102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGL3"/>
    <dbReference type="STRING" id="86630.A0A367JGL3"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="248" mass="29095" checksum="FCD0C43B1EE549FE" modified="2018-11-07" version="1">MNQDESGRLRVERVLHDRRPKRSDRIEIFDGRHTAQNISAYGFLLGLVCGGGLLYSFYGQIPQLGIFLVALPIFHFLEYVATALFNAEKLSLDSYLINHGRQYHAAHTAALVEFIIEYYFFPNWKQFGYLSYFGLFLLVIGQGCRTIAMFSAKHNFSHHIVDHKENDHVLVTHGIYKIMRHPSYFGFFWWALGAQLLLGNPICFIGFIFVLQRFFSERITYEEYTLERFFGQEWRDYKSKTPTLMLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JGV3</accession>
    <name>A0A367JGV3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">WDR81_2</name>
        <name evidence="2" type="ORF">CU097_006367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001347">
        <property type="protein sequence ID" value="RCH89115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JGV3"/>
    <dbReference type="STRING" id="86630.A0A367JGV3"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH89115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="312" mass="35535" checksum="A3E0DE29DC50737D" modified="2018-11-07" version="1">MENSFKTQELKQLLYKDLKIDMAFPFFPLGAKAGSAACCVVDTDWIEKLTNNSTEIIELKSPHHSRITTEGGANQKQSPTVNVYVNLLLKSTANSLSIYEPSELKDQKQTTGVSITNYLKCLAEGKEADQKIEALNDDFGVYKPIFNPADETHEIFIQRILDLLWPKCNWFKKTRENTTHIFLEKRKRSDSQETTENCNSNLSDMFAMVETENAYYFLSSYRGTTLQDLLTYNPGVLNTKLKKGFVTYQLLRVVASLHSRGIMHGNLKASNILIDENLWIQVTGLEYEPNPADFGKLIKRLLMSAKLLIHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JH98</accession>
    <name>A0A367JH98_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_005028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="PJQL01001315">
        <property type="protein sequence ID" value="RCH89297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JH98"/>
    <dbReference type="STRING" id="86630.A0A367JH98"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="590"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH89297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="789" mass="92302" checksum="898A450825E5E6D3" modified="2018-11-07" version="1">MARIEDNKRRSSDTDEQGVSIRPPPKKRFMTQQSSNDDQEDTEELADIFKEPLEAFRKEAIIRQWKDYMRSANRWKKYVEQAEANNLRNEESLRLWEDSFKKLQVFLSNVIQDGMSSLGEALVMNIDKGDLDIILDEEWATNLTPTMLNAYRKKEFVDLTISKLNHLVETWINRREQIITGFDSVFENDSLKETQQEHKQALTHWVNGQRSLQEIKTQLKSKNFKLLMLKEEYRLLNKQLTASENNIQQAQLDLEKMENKKFVSEDVKMDIENDNKNINHGSVPVEGSVTTYNNQAISQDPLFHIQQMLNQKLHEIEMIKEDRIALKQQIARLEMDLICVPESRIYKAMMCRQLFQTRTYQKDKCNHLSDICHDLQMNVDDLSSNRRRFIRDLDYEQVSHFKDMESQLRKLDTDLTRIRGQRDALQMNLEERKASTDVGKASIAELKIVADARKERVSYLETELLRLQKKMAAKTGVKGYYELVSNSSGKEPLLAPLENELKSIEEKVQEYKNKICNILPQEKVENELKQLSQVKEIQLAATLFKEKYGLDPMLIDDEQSFELTLQDRIKKETSIILEVNEKLSALQAMEKQLLSEIESVAKAYGKLEEENVKKVQELAIIEDEIIKLQAERVKYSQIFTALNKSKDAHAILANALNKQIEKQLAYIKQMTEREKNLTNQVTCLDRKLAISNSIYEVYKQKNDEVKLLLDELKEKALVSKDKITELQKSIFEKVRSIEESAHARLRLEESRELLKRKMGAVSKSERPAEAKLRKEREEYRVFTTKLQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JHW7</accession>
    <name>A0A367JHW7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001272">
        <property type="protein sequence ID" value="RCH89533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JHW7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH89533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="92" mass="10414" checksum="6AC1C1BF91B81B02" modified="2018-11-07" version="1">MPVVSISVSGRLNMPSNSIYDFCRENKGTVTEKAHQVQHMLPLLLGFFHDLKVSVDETAKIIKELKVEDEAVKKAAAKRLYCVISFAFRFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JI06</accession>
    <name>A0A367JI06_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_006048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001304">
        <property type="protein sequence ID" value="RCH89351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JI06"/>
    <dbReference type="STRING" id="86630.A0A367JI06"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="70"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="383"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="303"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="600" mass="66863" checksum="DF712ED68EBEB9AD" modified="2018-11-07" version="1">MSGQISASKAKRLAARAAKADKKGGKSGKSTPATASGSNSGDELNMESLRIHSERTATGVYTSQERSRDIKIDSYSLNFHGRVLIDNASIELNFGRRYGLIGSNGSGKSTFLASLAGRDIEIPSHIDIYLLNQEAEPSDMNAIEAVIHSAQNEVARLEKQVEEILGQEDGADNPLLDDIYERIEAMDPSTFETRACTLLAGLGFTTAQMHKMTKDMSGGWRMRVALARALFIKPTLLLLDEPTNHLDLEATVWLEEYLKTYDRILVMVSHSQDFLNGVCTNIMHLTSKRKLIYYGGNYDMFVKTKEENEVNQAKAYAKQQEEIAHIKKFIASAGTYANLVKQAKSKQKIIDKMEAAGLVEKVEQEATFKFSFTNVPKLPPPVMAFQEVSFAYDGNPDHYLYKDLELAVDMDSRVALVGPNGAGKSTLLKLMNSELVPTGGRIQKHTSLKLGKYSQHSADQLDMELSPIDYMRKKFPEEGSDVEFWRRQLGRYGLTGAHQTSLIKTLSDGLKSRLVFAELAILRPHIILLDEPTNHLDMESIDSLADAIKRFSGGVVLVSHDFRLISQVAQQIWICEKGEVKNFEGSIKEYKEALRKNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JID3</accession>
    <name>A0A367JID3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apoptogenic protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_002759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001282">
        <property type="protein sequence ID" value="RCH89471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JID3"/>
    <dbReference type="OrthoDB" id="6246201at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH89471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="20383" checksum="F5D4ED2B14B733E6" modified="2018-11-07" version="1" fragment="single">HSLRSTVSTRTLTTVCTKKIKKRPTEDLSKPVAADMIGTPDPISNLRPVKYYIPPDETKEEREWRESCQRVDEFNQSFWYKNNLMFAEAKAEYEEQLRKRGQEVTAEAMSVFYKDFLNKAYDRQMEYNRNWWRMNIAQLYPGLKAAIRSMRKTRQTEIDRGTGFWEKSFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJD5</accession>
    <name>A0A367JJD5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-Gal betaGal beta 1,3-galactosyltransferase, polypeptide 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B3GALT6_2</name>
        <name evidence="11" type="ORF">CU097_011415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001195">
        <property type="protein sequence ID" value="RCH89989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJD5"/>
    <dbReference type="STRING" id="86630.A0A367JJD5"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH89989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="532" mass="61207" checksum="E57C181945226205" modified="2018-11-07" version="1">MAKSNKLKKPPRFYFWRKTLSLSDLNLPRRSKITVDALRTLSLFPSVLGWAYNWQQALQVPLRDAGGAVILQSSQLDYVVASFWCALAGYWNWILTTSMMRRWIYHYEIENAIVRLITFIVITWSISAFVGSRNGPDQPIRTWMINCFILLITDVIRLSIVSDPKYHGKNANVGDPNLFLKLTITKVLIIPMSVATCLSVIAVLIQIDQLHYSTSQLMSGPVLLDANLTQASHDSILVLIMSCWTYTCFERRQVLRKTTLKLLEPYQHVDYRFVLGQPPSAQAQMLVGPDIIQESDIHKDMILVQSSDIETDKSRKVFEAFKWAKELNHEHIVKVDDDVFVRWDTIIEELKAMDPKPYYWKGLTYRNIPIRTLSNYKTLKTDYALPVIPAYTHGMLYIFSKDVLELILNPSSPRRFVHGDGENFAIWLFGFNISPNHDRRIHDAYDVCENDFIGKRMERTTDMLVMYSNLVSGRLPCTGFDLNGCALCYSCLNKRPSWRTINFACDPDKGIILREMVGFSQIAGLLDRTSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JJE2</accession>
    <name>A0A367JJE2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001183">
        <property type="protein sequence ID" value="RCH90058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JJE2"/>
    <dbReference type="OrthoDB" id="2263377at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH90058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="213" mass="24208" checksum="2B1A59DFE455A963" modified="2018-11-07" version="1">MAFRNKNIKLAEKENSLNSMRVLSLSFIFPISKLESNRSIASYVDNDVAVIIKFLGSEINIDFPKVFDAAVLYCKAIVDEDVKGIPRDKNDMAVIIKDLSAIDHVDDNGNKPDFMLGISENKRKEVWFFFVEVKRPNVTNHYQEEGNFTKLMKQVKSSIDEQLHLGAEGPISLGLLVEGIMNLAADGIYLPVLVKNFRLMEEIHDLVHINQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JLP7</accession>
    <name>A0A367JLP7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">CU097_009886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001055">
        <property type="protein sequence ID" value="RCH90870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JLP7"/>
    <dbReference type="STRING" id="86630.A0A367JLP7"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="226" mass="26390" checksum="660D10C901A7BCA6" modified="2018-11-07" version="1">MQHSMRDQVNACLTEYADLIKKYFAFLSTAADHVTLDEANNPEHIIKEIVALEDKLQKSVEQIEEHQKRQQKIIQVQDEIHQYNKTLLNLVQKLNTSRNELDQHLSSAKIELKATEYARKSNIQFTDILSYASKLSKYTSAPPNFDVLNRDMKMDFEKPYPDEERMRRGLLYWQNSSQPHTEERFESSDSEMSATEDTTEQNANRQNEDTGGDPFWILDLNPDMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JM78</accession>
    <name>A0A367JM78_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pumilio 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PUM1</name>
        <name evidence="4" type="ORF">CU097_012774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001040">
        <property type="protein sequence ID" value="RCH90969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JM78"/>
    <dbReference type="STRING" id="86630.A0A367JM78"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH90969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="132" mass="15405" checksum="505ED5F7877A8224" modified="2018-11-07" version="1" fragment="single">FIIEAFHGQVYQLATHPYGCRVIQRMFEHCTEEQTCFEHGTEVDKQSFIDEITESSPDGLCPLVIMMKDQYANYVVQRMLDVVNDKQRKVLIEKIRPHLSSLKKYTYGKHLIQKVERLVAMQEGNADDTQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMC9</accession>
    <name>A0A367JMC9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_005733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001058">
        <property type="protein sequence ID" value="RCH90851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMC9"/>
    <dbReference type="STRING" id="86630.A0A367JMC9"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH90851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="322" mass="38396" checksum="1887213F27E40D4A" modified="2018-11-07" version="1">MHEFSCCNNNQLDRIQGHEAFKTIEPHAFFSSEMGQLLLEDHRFDIFRENIQLKWEKEQSDKMIESLQNELKSMRAYCHELKTMVEKSEETSKLLATKMNKEQELKTQISDLKQELTLLEKTNDTLNMKYKRLNEKHETLKITHDVLLKEHEQRLLLFRKDTRVIERVARLPKFEVAPVKHPLDVLHSVTQQTLDKIKSTDVRLLNKRLKRIFDMTELSEMSNKMIMTLLDDLDRFHEQFDWVHTCPDINRHFFPLVELVCNMMKEMCTIKMTLNDLQADYVKRIKKASSPTTTNRHTIIIIPEEKSTWLENFINTFWSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JMD2</accession>
    <name>A0A367JMD2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-and gamma-adaptin-binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001020">
        <property type="protein sequence ID" value="RCH91104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JMD2"/>
    <dbReference type="STRING" id="86630.A0A367JMD2"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32878" checksum="03CFACE95E001C7B" modified="2018-11-07" version="1">MSLKNKILVTSKQNGQSLQFVKDLFKESNSPFPDSLIDKRLEETKGDITGISIPYKIDTKYYTANVDLWVDEVDQQETAKVYSQKEEVTKAVDCFVFVMKETEHFESIKMWLPFLEQAEPNIRMCINYGSIKEEEAAEMNDWCLSHAFDYVDMNEVKSDVPFDKVGIELALDIIQTNLWEGMVKKKKKKMTEQEEEQDLIREIQELQLYKEEEEEEEDMDLPSQSEISEMQSKLFGSIDEEDGLDKTFQMLQSMREHGKTLSDQERRKMAAQVALSFAAQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JN66</accession>
    <name>A0A367JN66_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_008783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000975">
        <property type="protein sequence ID" value="RCH91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JN66"/>
    <dbReference type="STRING" id="86630.A0A367JN66"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="174" mass="20703" checksum="EFB2C6F95F1DAFDF" modified="2018-11-07" version="1">MKKMPECWFYSKYGECCNGDECMYLHIDPESKQKECPWYARGFCKHGPNCRNKHVRKLVCQNYLTGFCPDGLNCPNGHPKYELPVMYTLPTEVEQQKSQQTQQQQQQQQPQQQQQQQQQQSQQLHHPQQQQQQQHYNRPPGTFRRLEDVTCFKCGQQGHYANRCTQGRIRQQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNH1</accession>
    <name>A0A367JNH1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation protein spt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SPT3_2</name>
        <name evidence="6" type="ORF">CU097_012907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000965">
        <property type="protein sequence ID" value="RCH91477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNH1"/>
    <dbReference type="STRING" id="86630.A0A367JNH1"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH91477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="302" mass="34366" checksum="10D3B5A4E58716FC" modified="2018-11-07" version="1" fragment="single">NSRYLSAEDILFLIRHDRAKVNRLRSFLSWKDVRKNAKDASGEQVEDVVEETNTAGKLHRSIIKLPWELINQFSDAIIKSVNGEDESEDEDELEAYNDSAQRLKEADEVTRAMTKEEYVHYSECRQASFTYRKSKKFRDWANMSAFVEVKPNDDIVDSLGFLTYEMVSKLTLTAIKIKRDMMAAAGEQEDEPVGLGHKRKREQENQKSVKRAESSLSNDGVSITVTSADGTTATTTESSPDSEKEENSNFDADNQGLFMPSRSEQTPLLPEHIHEAFRRLQQVPQPLKNFRGGLVRTKISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNL3</accession>
    <name>A0A367JNL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000965">
        <property type="protein sequence ID" value="RCH91475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNL3"/>
    <dbReference type="STRING" id="86630.A0A367JNL3"/>
    <dbReference type="OrthoDB" id="2202318at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="1">
        <location>
            <begin position="295"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH91475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="418" mass="47062" checksum="AEC9F87BFA5DF332" modified="2018-11-07" version="1">MSNSYYSNLFNEPLYFDYNSLDQLPSQADTELEENFFNCEELLQNRTTAPPAFFQIQNYGASNFDITALQTVPDNAFTALFGPDFLANPSTSQQPMVSTAQRPVTPPDILLPTIYVAPNPQPIPQLMTYSAQHQITASNSSDASFSGISFCGGSSSGDTSCKGISSDDTKLISPSQGLMDPYASIKKATLNINARLLQSFPYKYCTDRLVDGRFCLKFASHQVNPGESFNGFRNDNTPTLWLRNDYNSLDGSIPVHPITPRVNNTERRILYVGFEFYNGTGHKSKKNKKGDKIDPRDIGEVAVSCIYWPQKKDWFITSTDFIELIEVCLLMHFCREERNRIRRNLQCFEPITLTKNAEKKDADPVFFARVMGYDEPTTSKIEKDIKVFRWSTLVAGMNKVINSFVASSTTCSRPPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JNS4</accession>
    <name>A0A367JNS4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000945">
        <property type="protein sequence ID" value="RCH91610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JNS4"/>
    <dbReference type="STRING" id="86630.A0A367JNS4"/>
    <dbReference type="OrthoDB" id="2266750at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH91610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="537" mass="61377" checksum="B27BC5FA0554FA59" modified="2018-11-07" version="1">MIRAQRLLFYILFIAFFAFFSISVFPRLKPTSSPAINSPYAPQQPPSAHSSPPRKVDPNEEKYLSWFPHSDFPEQQECFRNGIRLALETNRTIIAPMLRINKSYPWMPFEDLAKRYEAQDKKILRDLCNSNQYNWRTELEPCETIDEWTEIPWSSIMDLEAIKKDYGVRIIERTQGHGWGVHESALPEGSVRPEDVAVVDVMTFKENGTDWEHVDPAMEALKKKSDGSVYRWIQNHFLSKQQNDEKPKEPFKFVLYDSQLRAIDAKVIQFGALSSAARYATPPTEIQMSLRKAMMKTHFNVPDQMQKMTEQANKIVSALGGRFEYSTLILNLAKLVALDARAGTIQHLDVDGKAPQSDVAAPKSMSELSKQAKKDLMDALVLEIFGDIPINQAVSAAMPIKRSKLSEFLGNGRPFPITDPVQRRELLDACVDYHKHVERRYPIYYLISDMDVAPESQPDIFGPLLDMFPCIFSKQDMLNWGIQTEDWSKGQPGLVDGVNYEKLFQPLLDILIAGKGYSFFEIPTTPLTRFLNWSPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JPG2</accession>
    <name>A0A367JPG2_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CPR6_2</name>
        <name evidence="12" type="ORF">CU097_011486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="PJQL01000922">
        <property type="protein sequence ID" value="RCH91775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JPG2"/>
    <dbReference type="STRING" id="86630.A0A367JPG2"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH91775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="364" mass="40502" checksum="20862691D67A9244" modified="2018-11-07" version="1">MSNPRVYFDITIGGKPEGRIVFELFKDIVPKTAENFRALCTGEKGTGKSGKPLSYKGCTFHRIIKNFMVQGGDFTAGNGTGGESIYGEKFEDENFELKHDKPFLLSMANAGPGTNGSQFFITTVPTPHLDGKHVVFGKVLKGKGVVRALENLETVSDKPVKDAVIVNCGELAEGEDDGIPENADGDNYEEYPDDYEGSKEPNDVLEIASKLKDIGNTYFKKGDHENASKKYIKAIRYLNEKPAFDDTDPEELREKFAGVRIPCYLNRAMCALKLGNNNDCIKVTTTVLEYDPKYLKKTDITKAYFRRGMAKVNTKDFEGAIEDFEKAHEQDPEDAGIKRELANARSKLAAKKQREKNAYAKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR17</accession>
    <name>A0A367JR17_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IML1_2</name>
        <name evidence="4" type="ORF">CU097_001545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000844">
        <property type="protein sequence ID" value="RCH92325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR17"/>
    <dbReference type="STRING" id="86630.A0A367JR17"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IML1 N-terminal fungi" evidence="3">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH92325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="768" mass="88119" checksum="2971F16720F7B800" modified="2018-11-07" version="1" fragment="single">MPPKGFLLSNKPIVLWIHDLGLTHHNDAIVNPEIFPNFRDGQLLRIHCPPEQEKDQQTQEQEATEYVIVKGYAPDKESLTKQLQLSISKDLADRFNLRSRQEVYVELIDPTSVSVDHIELAFKEQYLSRSDMWRLQQSLKSTCAYLEKKILFAGSIKATVKRMFRARQEITSGYITEHTRLIFRSASAKYFLFIQMSKEMWEFDEDGELYFEKAVSNFLPQLFSRWKEEGANHVVSIVLFTRVFYEAHNGDPLLNKAEDGRYYKDFYKVLADWETSDDWMSIIGQLKKEQANFQPTVLLRSEPDGRQVMSGQISMAFEGNVLEAINLALNPFDKHYVDRDLMRTGLSIILITPGVGKFSVNKKLLRLTNERMTDNGIAMDLVCLSPLPLHITPLMYYMDAPLAIDENENRKQFTNFGASPEKSATTAKVLGYMDPLYQDNDDKPTKKYFNVPHWVDCSFYHHETGRFLKQDKFKTRCKMYELQMMGIMEHDLKGISVPYLSEHQKSIRPQKSSSSLTEKMTSSHEETTTYLSRSANISTSIRRSSFLAANSEITSSYSRRAYETYDASLFKSTPEPRFYKKPVSATKMIKTFHNARSPEDSPEKLENANEFWKNASSRHKSTTTWHYTGEQRRIPSIISQSMGTKGPLDRKEELKGSEPSPTYAKDDRFRSLRRGTMNSTDGKYASVSMNLPFDRGEDDDAVVVSSSTVDPVPIKLRGDMNNRTSTTTNKTNHSPRSLPSIHKQSGNSDLVLRTSVNRSSPSHTLNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JR96</accession>
    <name>A0A367JR96_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transcriptional repressor proteinral negative regulator of transcription subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NOT4_3</name>
        <name evidence="14" type="ORF">CU097_011740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000830">
        <property type="protein sequence ID" value="RCH92426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JR96"/>
    <dbReference type="STRING" id="86630.A0A367JR96"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="929"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCH92426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1248" mass="140200" checksum="9B8498122A8D1797" modified="2018-11-07" version="1">MSSDEEDPDCPLCMEELDIADRNFRPCSCGYQICRFCWHHIKTNLNGRCPACRRLYSEQIVEFIPVSAEEIMRLKKEKKEKDRQTREMRDPTRRQLSNVRVVQKNLVYVLGMSSKYAYADNEIFRKYGKIDKVVISKRSITTNANASVGIYVTFAKKEDACKAIEGLNGIEIDGKTIRASYGTTKYCTYYLRHMACPNPNCMYLHEPGDDVDSYNKDTVAIGKHSNTASTSLNGSTYPNKKLATSLKPVASKAAVAESKPSASATPRTWAPIPKVVPVSPAVAEAVPETEEPVVTPPMQSKEVSAKAKTAASPVLLKPSKSTTTKKTVVEKAKKAIKVNLEEEEKPALPPTASWAKAQPSVSLHENVITPTHFGPSLSDAVQTIQKPKQSPSLKVKKEKKSKGRMVRLEEFEEAEREAKKATHQPKDITQNEPSTEINTAQEISTQESLPSAIHDISTPMKASVGIEKDQGSFDANSLKEKETRDNSMESDKEITENDEDITMNESEVKTEQPIETAKTEAASSMEKPATGSLKTGNVEADVQQIEDLEEKQLMDADQSNQDHLNEHIALQETLKIDLNIEKRQKEDVFDVQQPTEKEAADLGNVLNEKQDERTKEKVEVLACLNEEVIKAFDVAMANETLPENLEKTHGHNEDTAYSNDTQSDITSSGLSEHIPSPLVAMERLSTLVEQEILTDIIPSSRQQQPLEGNLPKETLHTLENNVSAWPESRRQPIPPPGLPVPPILPEWMSRSFDPFNGQDPSLIAARRLQHSQRMMEASGLFGMNNGFPQHRPPPPPLPNVPHFGFPPNLNENVPGFSHQPPPFPNMLARPPPPSHPHGMMRYHPPPHPHPQEMLNMSRFGGPPHHQHPHHGPIDDTNKLRAEFNAMHLNGNIDELQSRENLRALLPNVNISFNDQQKVKMEELHHSHMMHRQGMLQRQSDQESHGSTPSSHHMSPLRHGSMPPNLHFHPPPPTPDHLQGNTPPNFFRQNSFRSSNQSVSSVDGNFTQDTNPDVRTEAQNFFGEFLRKAASSHQQESLEKKEEQHEAKPENPLMFQDPAIMSVSVTGNNDANHESNQSTMLQILGGQQPVPSSMVENQQYHIQQPRPVDARFAMNQQRMMMSDPNMDERGREQPFVNNANGNAMFMGMPPSFPPGQPNQDPMFNPNNNYMQQQQQYQQQPFLPFIPRFLEPSINTMGHIGGAPPPPNPMMRPPMMMPHQNDNFRNTGNMHHHHQQQQQQQQQQRPPGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JT50</accession>
    <name>A0A367JT50_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_009968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000736">
        <property type="protein sequence ID" value="RCH93134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JT50"/>
    <dbReference type="STRING" id="86630.A0A367JT50"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH93134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="336" mass="39854" checksum="FDBC4A9B17DFF94F" modified="2018-11-07" version="1">MHKRHYSDNKSNIAKYKRALSDQYYGRDSKHKVIRQEICRYLKENEEIYKFFVEDDQSFDSHLNNMQQDGTFGGNMELAAFAKLYKVDIKVYQPGLIYVIKGVDEGEEEEEEEEPRQVLHIAYHDWEHYSSVRNVEGPFTGPPEIKEERVQKEEQDDEGKEEEVLDSKEKVILNACPDVSIYMIRRMLKKYKGDTDKVIDRFYELRVTEKDKDIHLKERLEIDNDGNVDHLPLPEQGEEKGEEKDEEKDTEEKDKEEIEKDKEEPGKEKGKETDKETTEKEKPKKMSASERKKEAKRRQKEAKLIKERAKAARRVQREKEEEKSTNEPQTMKELCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTA7</accession>
    <name>A0A367JTA7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCR4-NOT transcription complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_013074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000732">
        <property type="protein sequence ID" value="RCH93173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTA7"/>
    <dbReference type="STRING" id="86630.A0A367JTA7"/>
    <dbReference type="OrthoDB" id="2236331at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="3">
        <location>
            <begin position="202"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="2">
        <location>
            <begin position="343"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="1">
        <location>
            <begin position="529"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH93173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="88360" checksum="AEAA4C6ACA275B83" modified="2018-11-07" version="1" fragment="single">LIKVYGEDIRKHLFYYLLVDISRDLKSSSSQVTLLTSHLSLDHSLISLCHAFGLLCTQNTSIDLDALFTCLGLDYFSKTVISVSLFRNANRQIHNQAMTIFKTDSTRTKDMLTNTTIPSSLALYFIDCFATAINDKIYEPTSKDLEWILMLAKRYPSDDDTYINVFQAMLLELIQKEEINYLRNTLMMCKSQSLSAEDTVRFIEHLVETHVRWPTLTDPILQTIHEQEMLPYILNILPPIISLDLASAASRQNMINLETWLQQKMKAQSDIFIPACLDYLSQKIIIKAYSIQQEVNGNKPVLPSAKELDIILKALARSVTSPYQFEQYIKLQNQCYMLYPDLINTNINIQDIEREADAYYERLYNDQLSVDDMLSLMKQLKTVGNRQEQQLFQCMIRVLFDEYEFFSKYPEKELMMTSKLFGQLIQQDIMPEDQLDSCFLFILDALRNLAQPKMIAFGIDTVKQFIDRLGEWPQFCKSIVELPGLVQTQPRFIHTVRRTLLRNRPISFTSICLPVIPNSAMSELDGLFEVPEENTQRRLITAFSSIQKNNTESRIEEFTQVLKPAFYQWFSRYLIAEHITAESDNQTLCLSILRHINSKLLDACMLYESFSNIIHILHTTDVSTAHVNTLTNLGSWLGKITLAQNKPILEKHMAMKRLLLQSYDVDRLTLVLPLVCRVLKQGSYGRVFIPPNPWLMGILSLLAELYEYGDIPVSLKHEIEALCKSLSIKLKGTYCFCKQDTALTIKLLQADINAASILRNRRLIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JTD9</accession>
    <name>A0A367JTD9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CU097_011440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000725">
        <property type="protein sequence ID" value="RCH93224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JTD9"/>
    <dbReference type="STRING" id="86630.A0A367JTD9"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000003">
        <property type="entry name" value="Phosphomethylpyrimidine kinase ThiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="5">
        <location>
            <begin position="300"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH93224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="497" mass="53799" checksum="EEC29CB5968258AE" modified="2018-11-07" version="1">MKSMSNIPKVLTIAGSDSGGGAGIQADIKTLTSLRVYATSVITSVTSQNTLGVDGIHDIPPEFVVKQLTAVLSDIGTDAVKIGMLSSAAIINSVATTLKQFPEQARYVVLDPVMISTSGSRLLAADAIHALVTTLLPLTYILSPNVPEAEVLLNLPAGSISTLEAMRSAAKSIASLGPKFVLVKGGHLPFDMNGKKQVIDVLYDSTKDVFFEIVNGFVDTRNTHGTGCTLSAALAGELAKGSTVEIACTNAIRYVKVAINQALPAIGKGSGPINHFHPLRWSPYEGKTLLTAIKEKLPKNLWFEFIHHPFVRGIADGTLPTESFVYYLKQDYLYLQHYARAAALASYKSKTMIDIEANAAIVLHIAKESQLHLDYCAKWGITKEEVLNTPESVYNAAYTRYVLDKGMSGDLLDLKAAMAPCLIGYGEIGFMLFNDPATKRGKCPTNTLFQPSGIDELEALAEHSISSSEARFKEVCSTFEQAVRLEIMFWEMGIRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JU29</accession>
    <name>A0A367JU29_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPB3</name>
        <name evidence="8" type="ORF">CU097_009963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000697">
        <property type="protein sequence ID" value="RCH93443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JU29"/>
    <dbReference type="STRING" id="86630.A0A367JU29"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH93443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="280" mass="31847" checksum="66A9041DBBDDEFAA" modified="2018-11-07" version="1">MDIGSSYGLSGPSITIRELTKDRINFILSDTDLSVANALRRVMIAEVPTVAIDMVEIETNTTVLADEFIAHRLGMVPIDSRDVDKLRYTRDCTCSQYCPECSVELTLHVKCTDDRTKDVTTRDLISTNPSFTPVLQDKDDSGVLLVKLRKGHELKLKCIAKKGVAKEHAKWSPVSGVAFEYDPYNKLRHTTYWFEETEDEWPLSKNAQYEAPPDKDAPFDYNAKPDKFYFEAETVGSLAPEEVVTMAMKTLVDKLAYVQMQIQEEVEMKEQENPNAWNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JUU7</accession>
    <name>A0A367JUU7_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_011465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000659">
        <property type="protein sequence ID" value="RCH93754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JUU7"/>
    <dbReference type="STRING" id="86630.A0A367JUU7"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN RSV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH93754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="391" mass="45844" checksum="A14B590984CDFEB4" modified="2018-11-07" version="1">MNSTNNYCMDIRRCPPSSNINSHSDSVLSPPLTPALSQQHPFEKRHSTDLSYSYRYSIDYHHWINHSSMQHQNVNQQQQQQEQEQQTRVATTRKQPTKQNKHACTYPDCSWSFKRYEHLKRHMLVHTGERPHLCPYPGCGKRFSRSDNFHAHYRTHEKKAFKQKQDILIKEERMPVQQGISILPQQDQHYYGNYPLLPTPSPPKQQVNFVYNTSNNNNSINNQCEEEARKPHACDHPNCNRRFRRLEHLKRHMRIHTHEQPFKCTFPGCFKAFSRSDNLTQHKKTHERRGSKYTEPSAPQFMHPEPFTLAEFVRDNNTKSTNSSNSSLFGWQHPGDTSISSHSLSPASPAHPDHPYHHHHHHHHHHHHHHGGNTNTSTTKENTNSTESVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVB1</accession>
    <name>A0A367JVB1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="9">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_011472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="9"/>
    <dbReference type="EMBL" id="PJQL01000646">
        <property type="protein sequence ID" value="RCH93870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVB1"/>
    <dbReference type="STRING" id="86630.A0A367JVB1"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH93870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="590" mass="66600" checksum="D13192416029B35D" modified="2018-11-07" version="1">MIQLPEPPTTAGAAIPAHTPHAVSVTLPTWQDNIYYEEGNPIVTSKMECGYPRFFIHPLIQKLSARLVAKFGKPNDSCMLFPSHKVAESCRAFMHRYYQQPLGTIRIAEFEIVAPESHERVPIHIVLFPQDAFPIAKQFWQHSGDIISSRMAEYCLSILDGKQNSPEPTKQEIKPKLTLGGRSQSHYGSKHTKQSKHEEEKVSEEQTTYLEERYGRNLPVQFAKNAKVALRRRIAGILTDVSVGDRLITSNVEEQRQLKGERGIQGLSEEDVYLYPCGMSAIFHAHQNAMAIGDASLKSVCFGFPYTDTLKILQKWGAGCHFYGLGEDKCIDELEQRLQAGERVLSLFCELPSNPLLKSPNLKRLRSLADQYGFLIVVDETIGNFCNVDVLSWADVVVSSLTKVFSGDSNVMGGSLVLNPKSIYYKQLKDALKHDYEDLVWSEDAVFLERNSRTFKERSKIINQNAEALCDFLVSHEKVQKVFYPKYVCREYYDAVKHKTEDAGYGGLFSVLLKDEKSAAQFFDTLKCAKGPSLGTNFTLACPYTILAHYTELDWANEYGVSRFLVRVSVGLEDREKLLSMFKEALDAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JVI8</accession>
    <name>A0A367JVI8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein of the rab/ypt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000640">
        <property type="protein sequence ID" value="RCH93917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JVI8"/>
    <dbReference type="STRING" id="86630.A0A367JVI8"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH93917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24583" checksum="4461FC8B01CC82AC" modified="2018-11-07" version="1">MSSTVNAGDRKPIPVKLVLLGESAVGKSSLVHRFVNKEYAENREPTIGAAFLTQKCPVDDRTIKFEIWDTAGQERFHSLAPMYYRNAQAAIVVYDITKTSTLEKAKGWIKELQRQAHSQIVIALVGNKLDLVEDDQKDDSASRQVSYEEASAYASEAGLLFFETSAKKSTNVDSVFIEIAKHIPHEYLASNRNGVRANGAGNNASLDILRDANTSKQGSSNCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW48</accession>
    <name>A0A367JW48_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000609">
        <property type="protein sequence ID" value="RCH94166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW48"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH94166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="175" mass="20296" checksum="909FF9523D56EE94" modified="2018-11-07" version="1" fragment="single">ELSFSEEEEESDDGDLFSSGLCPMSTSPTNRFYTKFEDSMLSLSPPTRRSLFDDEDDDLVDKHYDPSDMWLYRIYHDNNTQNELSELVDQRQPNDVENKPPQSLNVNNNKTWVKRSTTEQRLPLQEITLGELQDEEMPAKKKVILNSGKMRMIRTLSPPRFNTKRKGKIAADSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JW73</accession>
    <name>A0A367JW73_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_004283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000610">
        <property type="protein sequence ID" value="RCH94157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JW73"/>
    <dbReference type="STRING" id="86630.A0A367JW73"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="345" mass="39726" checksum="EA59B73431C3456A" modified="2018-11-07" version="1">MAKRKRKTRTHIAPTEEEMDKIPKSFVMRSGIVGRSVTALVRDVRRIFEPHTASHLRERRSNRLKDFVMVAGQLGVTHFVIFSRTEKNVNLRICRVPRGPTLTFRVVEYALAKDCLALQRNPKTSDTEYRTSPLIVLNNFQQPGKEFKVMTAMLQNMFPSIDVQTMQLSQAKRVLLFNYNEDTQQIDVRHYSIGVKATGVSKSIKRVVNTDLPNLGDFEDISDYILKEAIVSESDVEDGPESTVTLPDQRRNEQRAVRLCEIGPRMTLELVKVENGVCGGEVLYHRYVKKTKRERKENEERAAKKAKILKEKEEARALREKEKEEEASKEEEATDEDEEDDEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JWL3</accession>
    <name>A0A367JWL3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_005637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000584">
        <property type="protein sequence ID" value="RCH94382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86630.A0A367JWL3"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1886"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2052"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2059"/>
            <end position="2074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH94382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="2087" mass="231665" checksum="4705CED8FAB9AA00" modified="2018-11-07" version="1">MPPSSGQRLSNRAQQDIPDIFLLDEQKVQPSETTEKQELYVLQWLAQVERESKTIDVETLKKAQPILEKSLLRLISLASARPRRPIRFLIGRCYIILYTRGDTRTLFDTVTALHSLIATNKNIDKETKIAAISTTGAIMGATGSKVLSLFAETATLFLKVIKNSNNPLILRLETIAAFTLLLKGAGKAATESILKDLMKQLRHGLVDKALVMRAASAQCLQSVIQHATQSFTQVEIESLLQHCFKAFENSTFPVRRSVSSLCATILLFTQRPATVDPAKPNIRHATTGEETVPAKAEDAVSGKSVTLMSVEDMLSQISGCYNRPNSSRELRTGLIETYATLFILLGTEFVEANYDTITKHVLCEILDKELSASDSAYLRAQVNFLLHHTINKKLLSEHGQAFAIKTLTNNWIKKWPPLMANQVAPSKQILLCVTNLISQLVSELEGAASSVQEVIVEPLFVLLSHPSFAVQMAAVWCIRCFCNACPSNLLKLLPKTMNLLEKDLNNLTNPTTTTKIFQRTIAYAYTAAAVLSVFPAHPIYTSFELSARAMSLSSQLVKQVHKDPKIASVQVQVAWTLIGSVMCLGPNLVKIHLPQLLLLWKSALPKPSGKEVNSIRSEPEWSFLFHIRECAISSIYSFLLHNSQSLVTLDIAKRIAALLNNTLAFLATAPVTFAPTTLSPCVPYETRLIDQSYCLRRRIFQCFITLRPHLPTYESSLNSLLRHSLTVFIELDKISASSRAQQQVTATVPGQFVSVWNIADGHGCGVTSKMRGYHVEIVSAVEDTYEEINRGKEWMTKDRFERVEELLERPMIGSLELDPFYAYTYHDGNKKKSYIPQPVSPSTSYVDASIELFATLFCNQPTPIQESTFELMIKAVKDPKLEKNSPRRAALLVNIVVALIGAFKHMAVLSRKKKEVIGLSPKATQLLQEILMEVVTHPDPYLRNVACEAIGRLTNIVGGTFVASQMQILVDLVVSNRDPDVRAGCALAIGYIYSHVGGMAAATHLKTIVGILLSLSSDPHPVVHAWALEAMAMTVSAAGLMFSSYVNSTLGMVAKLYLSETHEPGSGSIAVSNAGMSVGFTAYQEFGRIIYELIGTLGPELQASPKVRELCLNMVEELKLEPDERVNVEAIRCIQHFLMFAPKYLNVYDLVPYLQHQITSLHLPLKRAAVTCLYQLVQRDSELVFKAAQPGLDSELFKMLDTDPQLSDVKNVIRNWLQETAVAEPSIWVNITKRIVTGAAVPTSTTSDTLDNDAGKKSFDDEEDDEFGDDDADGFVDEDNTDITTTVADASGLTAKLSINVEIPPRWRTQLFSLECLQQTIELVAASGIREHFDLILARRRRQQAGLGDYLVFRVPDLIRLSFTAATAHVNELRLAGIHLLRLVIEKFATTADADLEDMLLLEQYSAQIGAALTPAFGVDSSSEIVAAAVKVCAIYVGSGIVKDLYQLGRVLKLLTSALDRCKGETKLTGVGEVKDLSSHASVMVKLAVLNAWAELQVASQRQGYLKQILQPNLSVLSSMWLRSLQDYARIRLESDIVALSNRSERIQTASNSSIDSMYSAATKDVVLPYYRRSWLKIMEAVATLVETQTPAMLEAIANNPDSRADGQASNLFYILFGLCIESLSRASSSSKTDSTTIPICLRTLRTFIQPSLASNQFVPKAVFLELMNVFDRLIRTESYKIQMIIVETVQRLVQNYGASYLCDDLENDSSESNAFPTTSKMYYILRVLINVFLQYVPGLSTKRTSLPPSDASDNLDILLNLSLDSFAQLVGITPRQYKVDLLAVCLRVFSDIFTNERFIQTLAPRALVSLKTAVFNFESNLLPTDVVYLSKIVTATTHTLLGNFYSLQYEKEELTTASQKNRLLATVLVMTGCPQATLHSTESRAQLINVLKMCLPSNNSELSATAHQCVRNFISLPEKNILSLATLGQVMTSSLLSFTITRIVAAKHTNDTLPVLNENIKTLLTLLNSVQEEQQYSVLCIILPTLTILLDDPPYNGTESRVHDASLTHLLSIATNMPAVFRETVLKLPHHIRVKLESAMRYSILEKQKQQQEQQQQIKEEQQRRAMNEDHKQPTIALKMDFSHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JX74</accession>
    <name>A0A367JX74_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_008080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000568">
        <property type="protein sequence ID" value="RCH94530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JX74"/>
    <dbReference type="STRING" id="86630.A0A367JX74"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH94530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="11942" checksum="3C6459CE59BBA725" modified="2018-11-07" version="1">MVELKEPANLNEFRELLNTNSKVIVDFTATWCGPCRMVKPIIHKLAEQHTEILFLVVDVDERADIASEYGIRAMPTVMFFKNGEKVDEIVGAGSAAKYEEKISQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JXA6</accession>
    <name>A0A367JXA6_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_010991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000556">
        <property type="protein sequence ID" value="RCH94632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JXA6"/>
    <dbReference type="OrthoDB" id="2256928at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="495"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH94632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="635" mass="73089" checksum="0578C5219F126582" modified="2018-11-07" version="1">MDTTTLPQELMLQSSANTPPRVMNRKVKESIDENTNMMNKKNDDSEEDSEEDTYSFENEQPPLLLDPKSSQSDSVYHAYSDNTCYHPTSFEGIKEEPSGRFRTISLDDTDSLSVQEAVYTASVFSNRIPMRSRRSSSQADSILHALAPPSHALKARRLSKNNDPEPDQEEMRRKRSIVHEYQKELNSHSAVSPRFMTLRKLSEVTVLPSHGISFANSADIPPVPHIPHIHANNNSNNNNTMTTSVTHPSPPPSISEPSDSSKPTSPDVLSGIDRIIEAQLQYHLGQMAWRVSESHIEARRFWEEQKSQVFGFTTNVIDRLERDLNQRLKDLIDSKTDLDPDVSSLKRELEWHKQQLAEKQCQLHELEVLRIRNSELEKQHDIDVAIIKSQQIDKEKIEARLLKYEETGAPGKKHQMKLFELKSYSKQLRSHVARVEQINKTLHQQVNEYQKQLEAKDEEIKQLLTKMKRKCSNDSTNMTARSSKHQTWVEIMESEDEAKKNAEMWANKYKELEKVHQELEIDHARLISEKDQEIRQLKQLDSMNRVQLEYMQLELKKKVQPSKHCACNKYQIQAPSRVSKSQSVIAKDGYLTFTAEINGQLSKYSVKIPPKQAQIPIKKTALNPNAPPWRGTFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JY51</accession>
    <name>A0A367JY51_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000533">
        <property type="protein sequence ID" value="RCH94848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JY51"/>
    <dbReference type="STRING" id="86630.A0A367JY51"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH94848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="44595" checksum="96C94A0BF5FD2898" modified="2018-11-07" version="1">MHPTLSTPSSELTVTQLADFAASITYLMWHARRPSTTTKMTTHEQSFANPMGNDMAYLMWQAKKPMTNMRHDHTIMFTASPAFKKFCYQILSATQLKDSVVYLCLKYIANLLQANPGIEGAEGSEYRLFVVALMLANKYLDDNTYTNKTWSEVSGMKINDLNIMEAEFLEAIDFNLHIRAQDFAIWKILLESCRDRYQFSYLDTPEQRQKAISNTLHTLGLYHDQFEHRIVQEKVQETDHISRITDLLDKSYKKYLASVENQERQRKVKLDDEYLNYYRLRPITTTPTVSITTTTTTTTTERRSVQPPLLAPNQLPITLQPPAVRYGGYSNACRYVNRNHPITNLSQKSWDPLAYSLRCQGSYTNATNDQHFNVTARPISWRNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K006</accession>
    <name>A0A367K006_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000452">
        <property type="protein sequence ID" value="RCH95572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K006"/>
    <dbReference type="OrthoDB" id="10273797at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH95572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="87" mass="10389" checksum="DECC3FD3678AE708" modified="2018-11-07" version="1">MIILSQLHISYNQNYYSVLEKKPGIVYREFRRLNTGYVKRTIDLYIGIRDTPPYLVLGYNHQKEFIEYNKPEGAKETSEPYYIYSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0D3</accession>
    <name>A0A367K0D3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin Tsp3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_013481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000475">
        <property type="protein sequence ID" value="RCH95361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0D3"/>
    <dbReference type="STRING" id="86630.A0A367K0D3"/>
    <dbReference type="OrthoDB" id="71600at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25217" checksum="B2A6F9ABBF53A56D" modified="2018-11-07" version="1">MMTITSFIGLFGAQLEHTGFLNTYNGLHAIILVFELVIISIAYNYRSQILDPYASILWDFFIEHDPQFVMNTEQLLQCCGYQSITDRALPANCSLSLNTNIGCKYSIISLIKRWHQWIILILIFLLILQSTILVLSIVLDIIVERQIREEERYLTLLKQSNHNYWLGHHSNHEGPSTNSGYFGRHRASLHTQKSNNSSTFIPKYGSTPSTSSATFYQVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0F9</accession>
    <name>A0A367K0F9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-ATPase V1 sector subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VMA4</name>
        <name evidence="4" type="ORF">CU097_014227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000445">
        <property type="protein sequence ID" value="RCH95658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0F9"/>
    <dbReference type="STRING" id="86630.A0A367K0F9"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH95658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="229" mass="26417" checksum="3665B28F4D00F28D" modified="2018-11-07" version="1">MSTTRPLNDEEVFNEMKKMVAFIKQEAIEKAREIKVKADEEFNIEKAKIVRQESLNIDAVFERKIKQAEVQKRIAQSNHINKTRLKILQERQQVLDEVFEEANQRIHQVSDDQEAYGTLLEGLILQSAYSLMEPEMVIRCREKDVDAVNSVLETVADKYEETMKHRPTFTISEEYLPESSAGGVIMSGHYGKITVNNTLDARLDIVKDEMLPQIRVALFGHSPNRSFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K0Z9</accession>
    <name>A0A367K0Z9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CU097_004200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000423">
        <property type="protein sequence ID" value="RCH95883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K0Z9"/>
    <dbReference type="STRING" id="86630.A0A367K0Z9"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCH95883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="178" mass="20158" checksum="D28FC9A3E0F3704A" modified="2018-11-07" version="1">MSSSLFKTVCQHATPLFRMAPAWTRSMSNVTIVPKDEVVSQLVNTLMRDGKKARAQRLVNDSMKHLSKKIGEEKDPYNLLREAIEIASPLLKISSQKKGSKVVHVPTPLRDRQRRRRAIVWMLEAASKRGEKTFEERFASEVFDVTEGTSTVLQKKLQVHKQALANRANAQVSYGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2C5</accession>
    <name>A0A367K2C5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_006822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000375">
        <property type="protein sequence ID" value="RCH96364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2C5"/>
    <dbReference type="STRING" id="86630.A0A367K2C5"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="146"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH96364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="197" mass="22224" checksum="80F1ECE255AD78D6" modified="2018-11-07" version="1">MYIDDQYDGTSLEGNIIKYGNLIALKHNMTGRYLTSRPGDNYEGGSGQQKAFAGGWETSSETLFIVLPRFGDERTGDDVNFGDVIRLKHSETRANLHSHPDIVSPVTEQQEVTCYGDDSLTDENDEWIVEQWGFDEAENEEFDVEDPTWYVGRSFILRHVATGVTLHSHDEPIAEDANEVTGYGAGPDENDRWRVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2F0</accession>
    <name>A0A367K2F0_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_009291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000378">
        <property type="protein sequence ID" value="RCH96329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2F0"/>
    <dbReference type="STRING" id="86630.A0A367K2F0"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH96329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="104" mass="11864" checksum="8B7E6C13AE972608" modified="2018-11-07" version="1">MGLSEFFSSFVPTVFADEEPQEEQPVEEQEEVVEEEEEEEEEPEDPKPEIMEACADQCAALKKHLDECNERVENGSSENCVEEFFHFMHCADECAAPKIFAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2J4</accession>
    <name>A0A367K2J4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CU097_010332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000371">
        <property type="protein sequence ID" value="RCH96413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2J4"/>
    <dbReference type="STRING" id="86630.A0A367K2J4"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH96413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="431" mass="47671" checksum="13A37EE74C35D6DA" modified="2018-11-07" version="1">MIQERQQHGIRSQTNLDYDNNNNNNNKTGTTENFVLNQFTSDQANDQMIELTDIFGPLDEMMFANHEHIPLNDVQISYQLDNRTSNEILAATQMPYSNTTNAATTYSSFPANYQQQNIIPQSLADLQPVMPCQSIHDLNMTQNSPIDNANASYLAILAASAPAGLGSLPNATLYNKMLATLPKETLASAERLLSPRPKSQQPSQGQFDFVPESSSKKTPAHYYGTFKVDSTPPRKSSPKSGSTLSNNTTNNSSNTSYPATAVSGENNTPICSNCGARSTPLWRRSVNDEILCNACGLYLKLHNVPRPKHMKTTHRSTNDDISRDDKSIACSNCGTNKTPLWRRDSAGSPLCNACGLYLKLHNEKRPLSMKTDVIKKRQRTESLIANNNEEQSVKRPRYYDQQTLMPTGYSDTALPGTGILLMSASDHSSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2R4</accession>
    <name>A0A367K2R4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_004247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000358">
        <property type="protein sequence ID" value="RCH96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2R4"/>
    <dbReference type="STRING" id="86630.A0A367K2R4"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="417"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="400"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="838" mass="95869" checksum="1055EF7F1B7D65E2" modified="2018-11-07" version="1">MLRRALICRRRLYSTIPFDDKPFKFSRFEPCCPDSTKIAANGYVPCQAHPIPDVLGKKIEIHEPMVRPSGLRHMVACIGPDALEWTRAKVEAHRGGIIHSIDHLKNRWLKENRPTHDDKAILSTVADRPASSKTTDIIMFPEFKIYKDVNPNRLETFYPVLDTMWKDASSSLPKHVECDDMQADAFILVCTHGRRDMRCGRIGPLIVEEFKRVIREKGLTGKVEVWGTSHFGGHKFAGNVIIHQRGLGGHMYGNVRQCHIADIVDRHIIHQRVIKDLWRGQVTPIQLMDSTKQHGKVKDEEIANLYSSLQAVIERPLPPSNNNNNNDNDTKSADEAKFIPPPPSLPISPSSSSPIIQLKPTATTSLTTPRDSNLDCPCQKIIDKQDIRHCALCRSTIPIIEELLSEKNNHENEIAILEEQLKHEQSRIAEQMESIKVLNSRLEQVTLELDDKTAKFQALQSDMELLNDKYVDEIERVAEIQHSKDMVESELEDLSRRLFEEANGMVANEKREKHNLEIAHKHLENQLQETRERLAAEQMQLKELRKRMEEMMKNNTSEDNNDMPKTPDHVKDITALLSEKISQPLNGKHIEIDSLMLEEFKEFVETGKSVPLKKIHSIPFMKNCQEEDVEACLRFGPNSRLSARKVNEAIALNSCFIEEAPQGFAEEQAKRLVSENPLKISAAKSMMWERFSNSNNQATVFSGCQACGRNDGTALPYRFRISYFDDWACIDRFCRDRLVAVCEFYVLIRNIRQGLYSNRSIPDLYHEAMRLRLQMFYARMGALPWTLQTSGSNDELKVITSESCPLPKTKKVIDDNNVRRGSLNIVQSSIQETKNEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K2V0</accession>
    <name>A0A367K2V0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_007772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000361">
        <property type="protein sequence ID" value="RCH96507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K2V0"/>
    <dbReference type="OrthoDB" id="2238225at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH96507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="146" mass="16825" checksum="1BA4C000E9E8CB47" modified="2018-11-07" version="1">MTSTSMTTQYWSLVWIYFHTHKYQDDCTHSLQKIAKVATAKVSRKTNTGKSYMDISIFAGCYELLVVGEYPYENGSTTPFLGSFVDKLKLVEEETKIINVPTIALNYIATTRSLNQYMKRHSHQLWAFTVLAFISKAFTQYQLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K313</accession>
    <name>A0A367K313_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_005116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000356">
        <property type="protein sequence ID" value="RCH96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K313"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="106" mass="11589" checksum="BF6771E2547B755E" modified="2018-11-07" version="1">MIPFLSDQGRNIALQWTRSSSYEKESDIQSDFGEANPGNNNNQALTLHRAIFWQRISSSITVIASNSNRLLFDSILPSLPPPPLPNATILTFTSAAPLVQPPQAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4G0</accession>
    <name>A0A367K4G0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_014946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000311">
        <property type="protein sequence ID" value="RCH97067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4G0"/>
    <dbReference type="OrthoDB" id="2275967at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="63" mass="7341" checksum="0799769ADC817E07" modified="2018-11-07" version="1">MLKSVGNRFSRVSPETFQKLNLYFVQASDEHIRLWSAQYASNGIYKFALDDKVEAAEDRQQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K4P4</accession>
    <name>A0A367K4P4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathogen-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_011985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000300">
        <property type="protein sequence ID" value="RCH97184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K4P4"/>
    <dbReference type="OrthoDB" id="65445at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH97184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27372" checksum="B34D56230EDAD096" modified="2018-11-07" version="1">MTLPDFMTDPNAVLKDKDHQWRYGRVPDYNKVNKAFEEEKTMNHAEGSLEWLVSNLVKNWEKEMSYKLNADEMRTIDRSKYRFSVNGQKWQTIDEMLEIGTYNALIGDSELYKASEMDFAESHKLFKRALRTFSWEVLQVYSGPPVVAFKWRHWGTMTGDLSVKIGNGKKLEAPASNEVVEAVGVTVAKVNDKFEIEELETFYDASILMKQLAKNRADKEQSDSGATECPFMSLNKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K5U3</accession>
    <name>A0A367K5U3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000271">
        <property type="protein sequence ID" value="RCH97509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K5U3"/>
    <dbReference type="STRING" id="86630.A0A367K5U3"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH97509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="426" mass="46047" checksum="A2D10A8A5AB180B4" modified="2018-11-07" version="1">MDNSSTLIDENTPLVQNKQERQESFRDLKGHVKALLAAFYMAMIAGLNDGTLGSIIPRIKQYYDITNETISLLFLCSATGFFISAGFNGLIVHHIGQLKAIYLGGTVQLAAYFVLMMGLPFPVMATAMVCSGMGMALMDAAMNVFTANLPLATLMLNILHALYGVGAMISPLVATYLLEHDISWKGMYVFLAVCSIINLITVTIGFMGVKLDEEHDEDNTDNQQSRKALTKAAILHPMTIIGALYILIYVGDEVVVGGWGYTYLTEGRHGDPIAMGRVISAYWAGLASGRILLGYLAGKFGEKLMITVFTMMIIGCLTVMCISADVVLNSSVIISIGLLLGPMFPTTISLASKVLPRSYHTTAIGFISALGAGGAALFPFITGMISGRFGILSMPYACIIMTLGMLALWAMIPSDKPFFGYFQKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K6U8</accession>
    <name>A0A367K6U8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_007126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000239">
        <property type="protein sequence ID" value="RCH97897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K6U8"/>
    <dbReference type="STRING" id="86630.A0A367K6U8"/>
    <dbReference type="OrthoDB" id="2329609at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH97897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="411" mass="47851" checksum="6B2004E72A1ED84D" modified="2018-11-07" version="1">MPFGLSKRNTLTICLLCLFVTLSYLFYITQDANSLLLRQQQESQQGQDQLTELEQLVDQELPVEENPLRQCISNTETRDNKTLTQEEWKQCLHEGEDPSFYLSIVLVTRMDDYAGNQHHRFQNFIDSAYLLAEHSQQKIELLIIEWNPPANKRRVLDAFRFRRSKHLTYRIITISPKIHSILPNLGNAPLHEFEGKNVGIRFARGEYIVCTNQDDIWSHNFINAIQSKVFEKDTIYVQYQSRHDIHDNLPPSIVKLEPFPDDKTLYNACKLREQDWGNYQLPGPSTVTAEDYWYYGDQAGDFTMAHRDTWKELRGYRETGGVAWVDIEFILTAVGTFGKRLVYSGDTFTCHQEHPNEWEKTPERHTAKTNVADILNNKTYLVNEEGKWALYNIDIWQEGLECVEFGGGLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K779</accession>
    <name>A0A367K779_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SPB4_1</name>
        <name evidence="19" type="ORF">CU097_003564</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="14"/>
    <dbReference type="EMBL" id="PJQL01000232">
        <property type="protein sequence ID" value="RCH97989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K779"/>
    <dbReference type="STRING" id="86630.A0A367K779"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000877">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="257"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="566"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCH97989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="635" mass="72566" checksum="56CF9908403C868B" modified="2018-11-07" version="1">MTAVPNTAGSWRSLETPLSGSILETLDSFGFETMTPVQAGAIPLFMKNKDVVVEAVTGSGKTLAFVIPILEKLLRREEPLKNYEVGAIIITPTRELAQQILSVIDQFVDTHECKDQIHPGLFIGGTTSLAEDISTFKNDHPRILIGTPGRLEELLTKTGQLVNVKELEVLVMDEADRLLDMGFSRQLNTIIAQLPKQRRTGLFSATMTDAISELVRAGLRNPVRIVVKVEDLLNKGTVQRTPATLEIDYLVCDADQKLLQTVRILETELNQADGARKFIVYFATCAMVDYFYKVLSRMSCLKPFSLHSLHGQMDTKRRTVTYSSFIELSPAIPAVLLCTDVASRGLDISDLDYVIQVDPPQDPKAFSHRCGRAGRAGRRGKATVLLVRGREELYVDFLKLRKIPIQRRRYILPNGETVDNSIKDETQADEKATSVQVQDPSLSKFITDIRSIVKTDRDLHDRSIKAFVSWARSYSKHEASYIFRVKDINLGQLAMGFGLLKLPKMPELKQQQQNLNTFIEEQIDWNSYKYSDKMREAKRQREMAEQKEKPQIQLKKKSVAWSEKVEAKERKSIRKEKKQKKREYLKRMQEEEEEKKKRALEDDEDDWEELAKEERLFKKVKKGQLDRSAFDDMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K7K9</accession>
    <name>A0A367K7K9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CU097_013271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000219">
        <property type="protein sequence ID" value="RCH98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K7K9"/>
    <dbReference type="STRING" id="86630.A0A367K7K9"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="235" mass="25858" checksum="E12659B473160A48" modified="2018-11-07" version="1">MLGQNEEQYDNPFARQNETFDFYQDRTIEPDTDPVRQQTEPLINPFANVSGKIGSTESTSYSEPTYDAAYTGEDTLDEPVSVTILRDVKQVGRKLQQVLNPRGDRGVLKDWDLWGPLILCLTLAITLSTSVPSNQSVPIFTGVFVIVWIGAAVVTINAKLLGGAVSFFQSVCVIGYCLFPLVLVAIISIFITTVWFRVPSSLMAFAWSTYAALGFLSESKAHLANRHALAVSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K8E5</accession>
    <name>A0A367K8E5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_000352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000197">
        <property type="protein sequence ID" value="RCH98430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K8E5"/>
    <dbReference type="STRING" id="86630.A0A367K8E5"/>
    <dbReference type="OrthoDB" id="2421456at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH98430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="642" mass="73802" checksum="950673BFF8866A78" modified="2018-11-07" version="1" fragment="single">TMESKGPPEDERRQIRKLEMELANLQHDHQETLKEFDELLLRYQEALDHADALQSVHGDNVDLKHSPTENKEILVLRDKVKYLERELALKSRQDNNEASTEAEPTSNKQETSGLLQQDESIVQNFSELQRRFEHLKMEAQLHSINIANQQTIEADIFNQDITMEELYEKYELQMASYRQEIKNAARLLKEVKKIKTREMRSSMQQFSANDDAYTNNGIPSISFEHRVLLRNITNLEKQMSEQNEKLKTEAKKFSSEIMEIILKKDSTSNEHSNIPTSSTSLSSSSPSAEDTVLSEEDIPEKQTNQILVLKQHEEARSALQTRLFIAKQDLMCHKSIISVLENKLRNVEITVALFKKRTENNVLSVDDVEMEELMLKMDAMKLQLEGSEKMESKSISDQQQDIRASLMDKIGFQQSFETKDHEKVKAILNEYRDNTKDIIDSRVDLLLLAKSKPVPERNALLAIEALSSVFVLRKSPNSSLHPSLNPAPLSKDEWKWDNTSSVKCLQLQSKGIRMNKAILTYLLNLPFNEADGDRVFTVRIDWAAKPVSTLMMPSYFDELLSFEETLNYLYAWCNHHLCLKEIMLPALRKCKQEVSFSSVLETPISADDGSSPNIYLTQSRCRRNQASATTDPDLEDLNNDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367K914</accession>
    <name>A0A367K914_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-protein Rab-11A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB11A_3</name>
        <name evidence="8" type="ORF">CU097_014072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000175">
        <property type="protein sequence ID" value="RCH98732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367K914"/>
    <dbReference type="STRING" id="86630.A0A367K914"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH98732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="211" mass="23589" checksum="9FCAC76FD467787A" modified="2018-11-07" version="1">MSRDDEYDYLFKVVLIGDSGVGKTNLLSRFTRNEFNLESKSTIGVEFATRSVQVDNKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKYATYENVMRWLKELRDHADSNIVVMLVGNKSDLRHLRAVPTEEAKQFAADNGLSFIETSALDSSNVELAFQRILTEIYRIVSNKALESSNDVIRPTAGQTINVSQPTEEQKQGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAL4</accession>
    <name>A0A367KAL4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HEM15_2</name>
        <name evidence="13" type="ORF">CU097_015399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="PJQL01000137">
        <property type="protein sequence ID" value="RCH99235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAL4"/>
    <dbReference type="STRING" id="86630.A0A367KAL4"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH99235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="395" mass="44613" checksum="8A287903B0FC073F" modified="2018-11-07" version="1">MNIGSLLTLQVKQQHLRNATRAISWAGIQRLYTTQTNTKPPTAVILTNMGGPKTVDDVQGFLLNLFSDRDIMQFPFQSAAAKFISTRRTPKIKEQYQAIGGGSPILYWTRKQGEAMEKLLDTISPETAPHKHYIAFRYVEPFTKDALEEMKKDKVQRAIVFSQYPQYSCSTTGSSLNELHRRIKELGMDTGIQWSIIDRWPTHPGFIDATVHKIEQKLAEYGPEERKDAVIMFSAHSLPMSVVNKGDPYPAEVAATVDRVMSKLGNKYPYRLCWQSQVGPKAWLGPQTSDALKGFAKAGRKNIVVVPIAFTSDHIETLFELDQEYASEAKELGITGWKRVDALNDEPLFIKAMANIVKEHIDKGEVVSKQWPLRCPGCNFDTCGHSRDFFTKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KAQ5</accession>
    <name>A0A367KAQ5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_014545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000131">
        <property type="protein sequence ID" value="RCH99312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KAQ5"/>
    <dbReference type="STRING" id="86630.A0A367KAQ5"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19093">
        <property type="entry name" value="AKR_AtPLR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH99312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="333" mass="37338" checksum="DA769CA64B760E68" modified="2018-11-07" version="1">MTVFLESSVVPTKDTKLTLGKAIRVPPIAIGCWQWGDKSYWDWTPEAEEDAKKAFNKAFELGIPFYDTAEVYGDGESESEIKRFRESYAEEEKNQQVIATKFFPHPDRIQFPDVLLSALKDSLARLGMFKVDLYQIHAAIHPAEIEVVADALADAYDAGLVKAVGVSNYGLDEIKRMHAALQKRNVPLASNQISFSLLRTIPEKSGLIQLCHDLEVAVLAYSPLGMGLLTGKYSPHGPFPEKRDRFFKKFDPEQLTKLLDTLKTLSHKYERSQSAIALNWCIAKGTIPIGGARTADHVEQNFTALGFRLSQDEINMLDKFAFVGSNNNEWQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBB6</accession>
    <name>A0A367KBB6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_010833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000144">
        <property type="protein sequence ID" value="RCH99131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBB6"/>
    <dbReference type="STRING" id="86630.A0A367KBB6"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH99131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11896" checksum="8EA7BA636A431197" modified="2018-11-07" version="1">MSYHEEAYKKIEQEENKAEWTHELLSAAAGFAAMRAYNKKKEEEGANPEDDHHLAKQMIAALAAASVDHLVETKGMDWVDRHKAKKEAEEEAKKLYAEKTGYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBJ5</accession>
    <name>A0A367KBJ5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Notchless protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NLE1</name>
        <name evidence="7" type="ORF">CU097_010619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000118">
        <property type="protein sequence ID" value="RCH99510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBJ5"/>
    <dbReference type="STRING" id="86630.A0A367KBJ5"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="201"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="409"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="484" mass="53412" checksum="4E7BC5AEDEAA673F" modified="2018-11-07" version="1">MAAKLRQKKLDAIAAAAMPPGQKVIAQFKTAEGESTGPPLNLPGDATPEQLELLLNQLLNQGDDPVPYSFYVGEDEIKKDLWTDRRDKSTEDTIVIVYQPQAIFRVRAVSRCTSTLSGHTEAILSCSFSPDGSQLATGSGDCTVRIWDLNTETPKSTLRGHSGWVLCIAWSPDGSTLASGSMDNTVRLWDPKTGKQIGDGLKGHRKWITSLAWEPYHLNSKANRLASSSKDHTVRVWNTSLRKMEFSIAQHTAAVTCVKWGGEGLIYSASQDKTIKVWNSSGMLIKTLEGHGHWVNTLALSTDFVLRTGPYDHTGKRHKTEEEAKAAALARYNALKGKGSERLVSGSDDFTMFYWEPEKSKKPITRMTGHQKLVNHVAFSPDGRLIASASFDNSVKLWDGMTGKFIGNLRGHVGAVYQVAWSSDSRMLISSSKDSTLKIWDLKKMKIKMDLPGHLDEVFAVDWSPGGDKVASGGKDKQLKIWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KBP8</accession>
    <name>A0A367KBP8_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SSO2_6</name>
        <name evidence="10" type="ORF">CU097_015511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000109">
        <property type="protein sequence ID" value="RCH99654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KBP8"/>
    <dbReference type="STRING" id="86630.A0A367KBP8"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH99654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="316" mass="35930" checksum="1DFFEE8C002486DB" modified="2018-11-07" version="1">MANPSISNNNNPYQKPHDWGYSPRGGSSNSNTYEMSQVSPAITSTQAFFEQLDKAKNEIDSLNYQIDQIANLHSTLLQSLNDQQSRRASNDLERMKASAQRSNFNVKAMIQEMQSGNSQLPNNSDTQMRRAQTGALRKRFLDTIQRYQDVERNYQLKYRQQIERQIRIVKPEASQEEVDDIIDSDGPPQVFAQSLMSAGRQGQARAVLSEVQSRHDDIKHIEKTIIELHQLFMDMSMMVEQQGETLNTVEANAEQTQTKIKEGNQFIAKAIQTAKSTRTKKWCCFFLCIGICVMIAILVWWFGFNHVGVGGNNNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KCL1</accession>
    <name>A0A367KCL1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARC19_1</name>
        <name evidence="7" type="ORF">CU097_005614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000087">
        <property type="protein sequence ID" value="RCH99982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KCL1"/>
    <dbReference type="SMR" id="A0A367KCL1"/>
    <dbReference type="STRING" id="86630.A0A367KCL1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH99982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="180" mass="20851" checksum="AA1D3E67D9ED00A7" modified="2018-11-07" version="1">MSNTLRPYLTAVRSTLTAALCLENFSSQVAERHNYPEVESSKSKEVLLNPLIISRNENEKVLVEPSVNSVRVSIKIKQADDLERILCHKFSRFLMMRAEHFVILRRKPIDGYDISFLITNNHTEQMYKHKLVDFIVHFMEEVDKEISEMKLSVNTRARIVAESYLVQVSYSNDVIGSLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KDX8</accession>
    <name>A0A367KDX8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_015184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000064">
        <property type="protein sequence ID" value="RCI00377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KDX8"/>
    <dbReference type="STRING" id="86630.A0A367KDX8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI00377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="387" mass="45030" checksum="05818D811B5494ED" modified="2018-11-07" version="1">MGNTTSNENSDSSKALTKIPKHLQPIKKKPTPKKSSSNSAPTQPGIIPRVKNIHHHSHNNHHHDNRCNNALDIARNDSSTSDLQFRWTQGRRFPNIENIEYFLPNDQTEQDRHRVQFYVIRWAFGSRHIVPPEIKHRLFEGIRVLDVNCGPGLWVGHPILDMAQDFVRSTFNLVDICDLLPQQPVFNVYTRKQEPEQKYPNFTFILHNILQTKKLPFDSNQFDYAQQHITALTYKQQDWPIILQELSRVVKPGGYIQLIEVDLMPQNLGPQGELWLEQIHQVLIEKRNTEPRLACQLEKSLLDLGLVDVQSKFVSIPLGSWGLDLGNLWKQNFESFFDSAKPFLTELMEISGREYKRKVQAMMDEFNEYKPFSNVYLAWGRVPDEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KE71</accession>
    <name>A0A367KE71_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="16">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DUS4L_2</name>
        <name evidence="20" type="ORF">CU097_012855</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = uridine(20a) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53350"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = uridine(20a) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(20b) in tRNA + NAD(+) = uridine(20b) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53352"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(20b) in tRNA + NADP(+) = uridine(20b) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53356"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53358"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the Dus family. Dus4 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01000056">
        <property type="protein sequence ID" value="RCI00515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KE71"/>
    <dbReference type="STRING" id="86630.A0A367KE71"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102267">
        <property type="term" value="F:tRNA-dihydrouridine20b synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000159">
        <property type="entry name" value="tRNA-dihydrouridine synthase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16 18" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI00515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="312" mass="35436" checksum="6B738356E5638325" modified="2018-11-07" version="1">MTDRKKTTPLDVLQRKKRINVCAPMVRYSKLPFRELVRKYNTDIVYTPMILADVFKSSEFARNTDFSTNHLDDPVVVQFAANKPVDLADAAELVAPFAGGIDLNCGCPQKWAYQERIGAYLMEDPENVRDMIRTVKGRVDIPCSIKIRVHKDLRTTYEFVKRAEAVGVDFLTVHGRTRLQKSTEPVNFEGIKLVKESINVPVIANGSIFSLKDADEMYEKTGVDGVMSARGLLQNPALFAGYETTPWECIEEYVRLALGYGTNTFIFHHHLMFMFEDIMCNAERKTFNTLSSIPAILDHLEENWGLDVSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KEG5</accession>
    <name>A0A367KEG5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threalose-6-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TPS2_7</name>
        <name evidence="4" type="ORF">CU097_010225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000050">
        <property type="protein sequence ID" value="RCI00606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KEG5"/>
    <dbReference type="STRING" id="86630.A0A367KEG5"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011071">
        <property type="entry name" value="PRK14501.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI00606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="843" mass="95125" checksum="4E7FACA796631A6A" modified="2018-11-07" version="1">MIPLTAENVAHYLPLSGQSPHIKGRIIHVTHQIPYNILRAQHTDHQLPLSPPRSPSSKYSPPMPALDELSSSDAVAAAPISKLARHHRRGTTLRMRFHAADWTVVERRGHQALYAGLQSLRKDYETIHIGWTGPIKEQGTRKLIAPNKLALEDKVKLQALLWETAHVIPVFLDEKSHGHYEGYCKQVLWPVFHYLERSSSCSSRVEKSYWDDYVAVNRQFAKTVIDRYQPNDIIFINDYHLLLVPEMIREALPDAAIGIFIHVTFPSSEVFRCLQTRNEILQGILGANLVGFQTYSYARHFISSCTRVLGCETTQIGVSHHGTLISVGAFPIGVDCARVSQFSKQPGVQPKMNAIRDMHSGKKIIAGRDKLDSTKGILQKLHAFEVFLRDYPEWRNKVVLIQVATPTHGEHSKLEAKISETVSHINGKYGSLEYTPIHYYHQDIDRDEYYALLSVADLLLITCSRDGMNTTSYEYVLCQHHKNEPGQLILSEFTGTAGSMSAAILVNPWDYAEVAKSINDALTMSLDEKVTRHEQLYRHVTSRTADFWAHSFIKHLVTISQQHDLQSRATPSLNSSKLLTDYKAAKKRIMFFDYDGTLTPIVSVPSAATPSPEMLKALQGLCNDPKNIVWVISGRDQATLDEWLGSNIKNIGLSAEHGCYVKPVGSSEWQSVVDGLDMSWKSDVIEIFDYYTERTQGSFVEHKKSSVTWHYRQADAEYGAFQAKECQNHLENAIVSKYPVEILVGKKNLEVRPMSINKGEIVKRILSKNPDTNLVICAGDDKTDEDMFRALSSAHQSPSSVWPERDSHLYSITVGPSEKKTHANWHVNTPQEIIQMLQTLAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFT3</accession>
    <name>A0A367KFT3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_013263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01000046">
        <property type="protein sequence ID" value="RCI00682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFT3"/>
    <dbReference type="STRING" id="86630.A0A367KFT3"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17974">
        <property type="entry name" value="DEXHc_DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="415"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="601"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI00682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1045" mass="120665" checksum="D405A3B6696CFF5D" modified="2018-11-07" version="1">MDLRSWVSDNSMKLFGMSESTMVDFIIATAQKVPSSQDLVHSLVQAGAPNDDSTQRFCSELFNRVPRKQSRTAAATIAEKQAKKKEAKEQAKLRKANEQFQLLMNEDGHEEDDDREIRKKEKKLRKKRKQDDLSDDDTEVKTTERRKRDHRDEKDEKEENDDMDEETRAEIERLKDLRERDELAQRIKEKDKQKTKKVVEDRSAKEGSEAFKRRNLADDKEARQRALPELRVLSNQKYLKLREQQQLLLLEKEIEDEERFFSGQKMTKREIRDLEYKKEVLRLAKARMQIDTKQDGYMLPEDYITEKGKIDRKKKEEALYQRYKDEEKFETEQETWEKSQIQKSSVKVRQEEEDEYDYVFDEDQKIDFVLSAKLNEPDPKDAELMARIDEAERRAKSIEEIRKSLPIYQYRDELIQAINDYQVLIIVGETGSGKTTQLPQYLYEAGYTKNGMKIGCTQPRRVAAMSVAARVAEEMGVHLGQEVGYSIRFEDCTSERTVVKYMTDGMLLREFMTEPDLASYSCMIIDEAHERTLSTDILFGLIKDIARFRPDLKLLISSATMNAQKFSEFFDDAPIFNIPGRPYPVEIYYTKAPEANYLRAAITQVLTIHVTQGRGDILVFLTGQDEIEAAQEGLTQACKALGSKISELIICPIYANLPSEMQARIFEPTPEGARKVILATNIAETSITVEGVAYVIDPGFNKQKSFNPRTGMEALTVVPCSRASATQRAGRAGRTGPGKCFRLFTQWAFYNEMEENTVPEIQRVNLSNVVLLLKSLGINDLVNFDFLDPPVEDTMIRSLSQLYALGALNDRAELTKLGRRMAEFPIDPCMSKAIVASEKYECTDEVVSICAMLSEQSSLLYRPKDKKILADTAHQNLVKPGGDHLTLLNIWNQWVETDYSVQWCYENFIQVKTMERVRNVRDQLVQLLDRVEVKLVSNPNPNDPTPIQKAITSGFFFNAARLNKSGDSYRTVKQNQTVHIHPSSSMLQKKPKWIIYFELVLTSKEYMRQVMEIEPNWLLEVAPHYYKESDLDNLNDKKKMPKQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KFY6</accession>
    <name>A0A367KFY6_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="16">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DUS4L_1</name>
        <name evidence="20" type="ORF">CU097_011403</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = uridine(20a) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53350"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = uridine(20a) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(20b) in tRNA + NAD(+) = uridine(20b) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53352"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(20b) in tRNA + NADP(+) = uridine(20b) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53356"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53358"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the Dus family. Dus4 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="PJQL01000042">
        <property type="protein sequence ID" value="RCI00752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KFY6"/>
    <dbReference type="STRING" id="86630.A0A367KFY6"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102267">
        <property type="term" value="F:tRNA-dihydrouridine20b synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000159">
        <property type="entry name" value="tRNA-dihydrouridine synthase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16 18" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI00752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="312" mass="35396" checksum="AA0A6CD4FCE81B9C" modified="2018-11-07" version="1">MTDRKKTTPLDVLQRKKRINVCAPMVRYSKLPFRELVRKYNTDIVYTPMILADVFKSSEFARNTDFSTNHLDDPVVVQFAANKAVDLADAAELVAPFAGGIDLNCGCPQKWAYQERIGAYLMEDPENVRDMIRTVKGRVDIPCSIKIRVHKDLRTTYEFVKRAEAVGVDFLTVHGRTRLQKSTEPVNFEGIKLVKESVNVPVIANGSIFSLKDADEMYEKTGVDGVMSARGLLQNPALFAGYETTPWECIEEYVRLALGYGTNTFIFHHHLMFMFEDIMCNAERKTFNTLSSIPAILDHLEENWGLDVSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KG24</accession>
    <name>A0A367KG24_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CU097_015400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01000024">
        <property type="protein sequence ID" value="RCI01127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KG24"/>
    <dbReference type="STRING" id="86630.A0A367KG24"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="194"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI01127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="372" mass="41970" checksum="C67BA6913B362752" modified="2018-11-07" version="1">MSEQAALEELVKKRRARHRRQLSHVQFVKRTQRTEKCPPSLIIPIEQQQEEQSPEEENNKDECNILRYISIGPSTENDHWPLFSWLWLVILIILFSGELLLNRQTSGEFFELYPLNSMIGPSVETMIQTGARFVPCMKPVSAMPTGQRYICLDTTLMNETLSLLAPSSPALFNTSCSLEDICGMIPFRLPGVPDQVVRFATPLALHTGIIHLFLDGAILLIISVKLEQAINSLRTSLLFICSGIFGHALGANFAEPLTVYLGCSSSLFGYLGYLYIDLLVHWKSTKKRLQRFVKLFLVTFVCFLLGLLPGVDSYSHLGGLASGIILAFFLMPIKEKAPDLKKRIIVYFVRLCSLCIYGILLGILIRRFTIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KH60</accession>
    <name>A0A367KH60_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000007">
        <property type="protein sequence ID" value="RCI01508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KH60"/>
    <dbReference type="OrthoDB" id="2207689at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="172" mass="19088" checksum="E6EC0F76DD5CAAF2" modified="2018-11-07" version="1">MTPLHNHKLVKLQHNTNKVSLPIDNPQEETIAKRKVSFSLDPPTVHEYEPEYDALPEIKSVCFFDDGWPGRAKQAMTSDSFMDFKARIEAKLSATNSSSLMAELNQSSNSSNSSPLLSNSLYKHKKSPLVQSLELCPETETDGSDSSSSPSNESPITTPVNTMNAWINCTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KHR2</accession>
    <name>A0A367KHR2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_015562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01000012">
        <property type="protein sequence ID" value="RCI01392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KHR2"/>
    <dbReference type="STRING" id="86630.A0A367KHR2"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI01392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="121" mass="14171" checksum="AC09EB624F446A53" modified="2018-11-07" version="1">MFKLCCCWIGYDILLEFIPIVGKVISLMFSLSLYKLACQAELPRSIRKKMLYHISVDFLLGLIPILGILLDMLYRAHIKNLRLLRRFLYERARQQNVKLAEEKALANDDRIPLSERETDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IJN9</accession>
    <name>A0A367IJN9_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005579">
        <property type="protein sequence ID" value="RCH77879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IJN9"/>
    <dbReference type="OrthoDB" id="2263744at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH77879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="103" mass="11478" checksum="B8EDFABD18E1C582" modified="2018-11-07" version="1">MPSSVRGRKPTVPVLSSEQVQNLYKQFEIQRRQLVCTACQTMNSLYRNRTSSGDPFQPSLICKYCKNYNAPTMANLLQSALTITETPSDANAQYPLEISGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IL41</accession>
    <name>A0A367IL41_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin type-2 heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MYO2_3</name>
        <name evidence="2" type="ORF">CU097_000753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01005204">
        <property type="protein sequence ID" value="RCH78389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IL41"/>
    <dbReference type="STRING" id="86630.A0A367IL41"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="1">
        <location>
            <begin position="24"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="208" mass="24411" checksum="981E7205D4D99F5E" modified="2018-11-07" version="1" fragment="single">HIIGKCVTQMWRLGYLAESEQLLFRVMDTIQKDCSSFTGEETIVPCAYWLSNTHELLSLVYSVEQDLEREMHYNSIHGRRAVGWHDFEKLVSTMKYELQCLEDNLYHHWLSELKKKLNKMAIPALIESQSLPGFISSDSNRFFGKILSGNNQPAFSMDDLLNFMNRIYRTMKSYYVEPYVMEQVLTELLKVIGIITFNDLVMRRNFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IMK5</accession>
    <name>A0A367IMK5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar DEAD-box protein required for synthesis of 60S ribosomal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DRS1_1</name>
        <name evidence="2" type="ORF">CU097_000522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004831">
        <property type="protein sequence ID" value="RCH78904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IMK5"/>
    <dbReference type="STRING" id="86630.A0A367IMK5"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH78904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="160" mass="19014" checksum="9A63BBE154199284" modified="2018-11-07" version="1" fragment="single">GRNGRSVTLVGEADRKMLKMAIKSTAGSQVKNRVVPAELVQKFKLKIEKLQKKIKEVLEEEKEEKAIRNAEMQLKRSENLIKHQDEIMSRPARTWFQSEKDKKKAKHQATEPKKEKVEKKTKKDKYEGMSRRKRRRLQAMEEEAEERRLQKEEKESKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPD8</accession>
    <name>A0A367IPD8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="PJQL01004542">
        <property type="protein sequence ID" value="RCH79371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPD8"/>
    <dbReference type="STRING" id="86630.A0A367IPD8"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="126"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH79371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="259" mass="29539" checksum="808F26D4C38E9AC9" modified="2018-11-07" version="1">MTISTGLANLICIGFTVIYVVGFYMFKIPGSRNHPPVIRARMKAVTVASLISVAIVQYLTTANLLTVLGLTFNIQALVKPLLLTSLLFLGPISIRYFDDELPFQKNFNFHRDVILTLTEPLGQRNYYVAPFTEELVFRACMIVVLYQANYSKGYLIFMSPLYFGLAHLHHAWENYYVLGGTRRAMIQSISASLFQFAYTTVFGWYVSYLFLKTGSLWSCVICHSFCNIMGFPDFSCIKEMCNGIFVALVEMQLYMLVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IPX5</accession>
    <name>A0A367IPX5_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_001865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004426">
        <property type="protein sequence ID" value="RCH79551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IPX5"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH79551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="88" mass="10174" checksum="95F0688F88F774FB" modified="2018-11-07" version="1" fragment="single">EPIRDVVIESASEPLRTHRSHPSQIYSLTFSFFVKVFLLHPSEYTSLTPKGVHQESPYTRSPEYHVPTLKKSLSSNMTSIQSICRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IQK5</accession>
    <name>A0A367IQK5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CU097_004144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01004201">
        <property type="protein sequence ID" value="RCH79926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IQK5"/>
    <dbReference type="STRING" id="86630.A0A367IQK5"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCH79926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="89" mass="9848" checksum="B9694BB3CD09749F" modified="2018-11-07" version="1" fragment="single">KQKNPPCPTLFLGNLSFEATEQSIREAFEWAGDIRKVRVATFEDSGKCKGFAYVDYFTVESATKAIRAPDKHVLDGPLVVATTEARSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ISJ7</accession>
    <name>A0A367ISJ7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_001126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003804">
        <property type="protein sequence ID" value="RCH80648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ISJ7"/>
    <dbReference type="STRING" id="86630.A0A367ISJ7"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH80648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="678" mass="70638" checksum="DF097CF10335FC03" modified="2018-11-07" version="1" fragment="single">VFIALTCIHLVEANVQQRDVAMPTSINNGPGSIYTLKKRAAEDEESDSEVTIKTSEKEAKKVSDKDNETEKSTKTKSTSTEKHTSTEKHTSTEKHTSTSSKHTTTEKPTTTENHTKTSKHTTTEKPTTSSKHTTTEKHTTTEKHTTTEKHTTTEKPTTSSKHAITEKPTTTEKSTTSKHESTSSSKHKETSTSTHKSTVTEKSSSSSTKETTTSKKETTTDSPAPITHKSTEKPSTTAHKSTTVTAEKSTTTEHKSTSSTHKETPTTSLHKSSSTTTEKHTITDKPSESHSTKTSTVTSHKETTISSEKPTPTTHSKSPVSSSKDSTITTHHTATSSSSKSTTTHHTATSSSSKSTTTHHTATSSSSKSTTTHHSSSSSSSEKPTPTTHSATTVSSSKDSTITSDHSTTSSSKTPTTTSHHSTVSNTSSSEKSTSTTHSTTSMSSSKDSTNTSTTTATNEPTTTDRVIPTTTDSSSSRTETVSSSTLTSDHFTTTTEPTATVTTTSSDDNTTTSSSTSGSTSATSDVATSTPTSGSTSATTGSSTATDTDTPTPTTNSSNGPTSTDNSSSSTPTPTDTDSTTKGISSTTTGNSETSTQTTGTKEPTPTDSSSSSSPTPTNDSTTKDTSSTMTSATESTTKDTSSTTGSSDTATPTSTYDSTPTPTPTDNTTTDSSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367ITR4</accession>
    <name>A0A367ITR4_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Curved DNA-binding protein (42 kDa protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CDB4_1</name>
        <name evidence="3" type="ORF">CU097_004020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003587">
        <property type="protein sequence ID" value="RCH81094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367ITR4"/>
    <dbReference type="STRING" id="86630.A0A367ITR4"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH81094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="376" mass="41160" checksum="CC1B4012B8A9FF03" modified="2018-11-07" version="1">MADTTEVKKPATEPVLDISDSTVQSKYKEAGRIADDVLDKVIKLCVAGAKIIDICIAGDKAILEATSLVYNKKGKKKISKGIGFPTTVSVNNCVAHFSPLPSDPESEATLKEGDVAKIQLGVQFDGYCSTVATTIVVGANGAVTGAKADVIQAARTALEAAVRMIRPGNKNMDVTKAVDKIAESYEVKPVEGMLSHNQLKNKTDGDKQIILNPTEAQMSGFKRCEFGENEVYCVDILISSGEGKVRPLKTRTTIYKKTDIRYQLKMAASRAVLSEIQTKAGSFPFSLRDLEDERKARMGIVECAKHQTVLPYDVVYEREGAFVAQYLTTLFVTKKGNVMVTNPRFDAVQIQTDKTVKDEEINKILASEWEVPKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IV19</accession>
    <name>A0A367IV19_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CU097_002229</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003387">
        <property type="protein sequence ID" value="RCH81543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IV19"/>
    <dbReference type="STRING" id="86630.A0A367IV19"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCH81543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="210" mass="24964" checksum="9F7863162A137C75" modified="2018-11-07" version="1">MTIYYTTTFFILVIEMIVFCILVLPLPSRWRRALFKFASTSPLVGKALNTLRIIFGFIFVLFIDAVNRLQRIEEGEDNHKHDYGYEVGLKARKFYAQRNLYLTGFTLFLSLILERTSSLIVQMLKREEELEYVKEEHVSTTQDQERLENMEATYKNKIAALKLEVDELRKQEKDMENLKKQVEQQSEEYNQLINRHEALQRRAKESKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX41</accession>
    <name>A0A367IX41_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_000674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003115">
        <property type="protein sequence ID" value="RCH82179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX41"/>
    <dbReference type="STRING" id="86630.A0A367IX41"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="370" mass="40455" checksum="1B94EEBB6A912D51" modified="2018-11-07" version="1" fragment="single">MYINGIKYACSTCIKGHRSSHCNHVDRPLFEIRKKGRPVTQCTYCRDLRKTKQVHIKCACNSKKGDHQQQQQPILIYRNTSSTCSVHSNDDIIQDHPKQHCTCPSLNNGTPMIRSSSGGGQAYLSSNVPQDSVDVVPGSLMSAPLCTTPLVVKEEVPSYSWALVTSPSANHIDLPHASSSSSSCSASTSKLAEDDNNNHHNLHLGFIFHKPSNTSRILDGQPRVRRRRSAKKSSSSTPTRPLASNVNYDTLINVDTLTGLSTPPPSSTVSSSEPMDVQFDYLTQQLEILSTGGFTNAEELTAILNNVLQKDNGLTVDTMFQENQILSTVPNPLSPLPSLPPTTHISSGLVQPQQQQHSPVNTPNINRSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IX42</accession>
    <name>A0A367IX42_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_005931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003095">
        <property type="protein sequence ID" value="RCH82232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IX42"/>
    <dbReference type="STRING" id="86630.A0A367IX42"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017049591" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="167" mass="19058" checksum="39F6B5049BE56655" modified="2018-11-07" version="1">MLHRSFTLALVTVAVILATLLHTADAASRSSVKNILKVTNSLRAKHHAPPLKWNNKLATYAQNWSNRCVFEHSHGQYGENLAYGYPNWGSVIRDWYSEVKDYDYDHPQFNAGHFTQLVWKETSEVGCGAKVCNNLCPGCKLYTCSYKVPGNMMGDNWRYFKQNVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXH2</accession>
    <name>A0A367IXH2_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_002339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003037">
        <property type="protein sequence ID" value="RCH82372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXH2"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH82372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="151" mass="17424" checksum="5512B166BB4E3688" modified="2018-11-07" version="1">MIFYNTKRDIRKNWLRDLIKGNTSLLYNQRDRQTKYYWSLSANEPDEGVEAVAKGGPVELQILKMIEKCNFEYSAPLVYLGYGGRELDGVPQLGRNERNKSNQRSFNEKYACGAYKYLSVDRSTVKKIFCNMLQRLVVIVPSFVLTGAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367IXU9</accession>
    <name>A0A367IXU9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HHT1_2</name>
        <name evidence="8" type="synonym">HHT1_1</name>
        <name evidence="10" type="synonym">HHT1_3</name>
        <name evidence="8" type="ORF">CU097_004758</name>
        <name evidence="9" type="ORF">CU097_005231</name>
        <name evidence="10" type="ORF">CU097_005419</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01003454">
        <property type="protein sequence ID" value="RCH81396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01003005">
        <property type="protein sequence ID" value="RCH82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01001138">
        <property type="protein sequence ID" value="RCH90335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367IXU9"/>
    <dbReference type="STRING" id="86630.A0A367IXU9"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCH81396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH90335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="136" mass="15355" checksum="0786D0DBBE68EE07" modified="2018-11-07" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDIQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J1C8</accession>
    <name>A0A367J1C8_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_003409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002572">
        <property type="protein sequence ID" value="RCH83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J1C8"/>
    <dbReference type="STRING" id="86630.A0A367J1C8"/>
    <dbReference type="OrthoDB" id="2275614at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase zinc-binding" evidence="1">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="143" mass="16362" checksum="2D4A9E2C8EF5B9F4" modified="2018-11-07" version="1">MVEGEESLNLPLKWKSGADLMSKMLSSHPKIINMIVHSLVGNASIAFIARLKLYCGSASQGTSALPSQSWHLPLQLWRVFWAILIPDKALTPWWRLLHGCIDIQQKFHRWNPSRWPSAVCRTCDNAEEDIYHFAANCTLKQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J201</accession>
    <name>A0A367J201_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Porin por1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">POR1_1</name>
        <name evidence="12" type="synonym">POR1_3</name>
        <name evidence="11" type="ORF">CU097_003881</name>
        <name evidence="12" type="ORF">CU097_013879</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002570">
        <property type="protein sequence ID" value="RCH83741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="PJQL01000457">
        <property type="protein sequence ID" value="RCH95528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J201"/>
    <dbReference type="STRING" id="86630.A0A367J201"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH83741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCH95528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="283" mass="30101" checksum="675CF2BFA27505BA" modified="2018-11-07" version="1">MSVPVAFNDIGKSAKDLLSKDYPVGGVKLEVKTTAPNGVAFKVTGQRDNKSGIIVGDLETKYADKSKGLTFTEAWTTSNHLNGKIELENNLAKGLKLELLTSLLPSVNEKAAKINATYKKPNVHTVATLDVFKTNFSVNSVFGQQGFLVGAEVAYNVLDGKVGRYNAAVGYSAPEYGVAVHATNNLSQYSASYYHRVNSDLEASGKATWDSKGSNAVALEVGAKLQLDPSAFVKAKISNSGVLGLAYTQSLRPGVKVNLGASVDTTRLNENAHKLGLAFTLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2N4</accession>
    <name>A0A367J2N4_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBC13_3</name>
        <name evidence="9" type="ORF">CU097_005829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="PJQL01002440">
        <property type="protein sequence ID" value="RCH84180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2N4"/>
    <dbReference type="STRING" id="86630.A0A367J2N4"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCH84180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="149" mass="16771" checksum="7565958C1E6C658C" modified="2018-11-07" version="1">MALPKRIVKETERLLADPAPGICATPHEENLRYFDVVIAGPSQSPFEGGVFRLELFLPEDYPMGPPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVASHWKEDEKGAIEQARQWTAMYAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2N7</accession>
    <name>A0A367J2N7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_003610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002429">
        <property type="protein sequence ID" value="RCH84214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2N7"/>
    <dbReference type="OrthoDB" id="2233065at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="240" mass="27942" checksum="89D7FE46AD727E43" modified="2018-11-07" version="1">MYSISVKVKPKVLIHMRLLYKNEQYKETDHKTRYYHITYHTQFSLVIMFENNDDVGSYPLETLQAISSFFCQQKATLFDYPYSEDNTIKFLYKIAKEVTVEEIQYENNFRHTLDIVLTSNEKCFNRSKKSLEGAPDIKKAERLIEKGHTYNASIKRQLSNVSTESESDLEFPEKLPVGTKRPPTASQIADEIAFVKRFKTNAGRMNWAQCLAEAHKNNLLLRYSTVSSLRANFSTHVKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J2Y1</accession>
    <name>A0A367J2Y1_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar morphoproteinsis protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VAM6_2</name>
        <name evidence="7" type="ORF">CU097_004940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002411">
        <property type="protein sequence ID" value="RCH84276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J2Y1"/>
    <dbReference type="STRING" id="86630.A0A367J2Y1"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="14"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="622"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="910" mass="103675" checksum="6A03FE4350C47098" modified="2018-11-07" version="1">MHDAFQVTTVVDKLNRIESIFAHGDRLLIGTGSGQLLVFDIKEPLVADDNEVPEVTLSKTIKTFSKRPIEQLDIIKEIDVLVSLSDGLVSLHDLHTFELKMALAKTKGANLFAVQTMVEMSPEEQVPVLTTRLAVAVRKKLLVFVWKDTQFCETKELNIPDRIKAMSWVGTTKICLGFLAEYALMDVEQGQLTELFALTGQAEAGPMSTLNSLYNMSIGSRGGKPMITKIPNNEMLLARDHISIFLGLDGTPTRKVGIEWSGAPEQIGYSYPYVIAILPKHVEVRNIQTLSLVQHIDLANTRFLNQGKLVYVASTSQIYRLTPYSFSSQVDQLVEKQEYKEAVSLLDQIDAVLVQDKEAKLTSIRTAYAHDLFRHGEYDKALELFQELDTSPEEVISLYPDMIAGHLAKKEEDENSNHDGDAKKSIEEEKIERPASRASTKSKATTVASSIKREPVPLTGFHLRDAVTYLIRYLTDKRQKLARKLNDPSVKSPKSDSVDNQSLLDQASLVDTTLLKSYMMTNDALVGPLLRVQNHCDVEECETILMEKRKYKELVDLYNCKGLHGRALDLLQKLGNQQDGPLRGVLPTIRYLQRLGIEHFELVLEYSRWVLEKDPKHGMDIFIDDLEKTETFPRDKVLKHLESISSDLVIQYLEFIIQELHDESPEFHNRLVIVYLDKINSDKKKNAGDTYDTRSRLLSFLTGSSFYKAERILTRLPDDDLFEERAILLSRIGQHDQALDIYVYKLKNYVMAEEYCTKIFRVDSKKGEEMYLTLLKVYLNPSNQQEPLIQPALDLLAHHGSHINASEVLSILPSETQLHGLFPFFEKYIRAANKRRNMDLIVKNLLKAEQIQAEEQLMYYKSRAVKITEDRMCPQCNKRIGNSVFAVFPNGVVVHYSCKEKIEQTQWRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3A9</accession>
    <name>A0A367J3A9_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CU097_003303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002369">
        <property type="protein sequence ID" value="RCH84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3A9"/>
    <dbReference type="STRING" id="86630.A0A367J3A9"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140361">
        <property type="entry name" value="MIT domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCH84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47031" checksum="119C0B744DC9EE95" modified="2018-11-07" version="1">MSTEAPVNAGHRFANAAEDFEEEESWEKAAEAHFKAAEQFQIALNDVKDAETAKTLQLLIANHKRKANDLDRKIQRMKTITTQKDNQLTAHHNNNMRMMGSSGGLRNALPDKKGNSSSNNNKHNGLLVSRLANRSEYLSSEDGLQRADGIGESYALLSNDDENDDPFNKFLEVVEGLVQNLINPAVAFASAPLNENDIPVPIATQTPLDPDMDHDLQLDNNNMMESFYIVPKPKDYQERQYSIIKTGKDDTLKENDSEKNKEFYQHENEKLRKQIALLTKRVKALELAAEEGNTLKSSIIQFRNDVHRQAKRIMQSHHESSMRLSAVALPSTGASSINVNSIRHPGLIGGGGNDLVNRLRELEEENRQLKIQNEKQKMLVSKYKERWEMLKENAKKRRASTATTIADSMNTEVNNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J3S5</accession>
    <name>A0A367J3S5_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CU097_005414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002332">
        <property type="protein sequence ID" value="RCH84566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J3S5"/>
    <dbReference type="STRING" id="86630.A0A367J3S5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="765"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCH84566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="814" mass="92222" checksum="0D86D689B8D789B2" modified="2018-11-07" version="1">MATSPTAESQSRQRVSRACDLCRRKKVKCDGATPVCANCKSFGLECTFKDMTKKRGPPKGYIEAIENRLYKLENFLAELAKSGDIQSSHLLMELNSPLETPTGEQIRARPVRRVPKSERSKVFFWQQDKAGKRKRESLLSDSDTKDYQQQEQDLSSREESMDEGVGQLAMDENGQVRYLGKSSGYYLLQSSRTYQNGAFHFANYGKKRKRIPPLRPVDPLELPPKDLSEHLIILYFRYFYPFLPLFFRRQLFSAVEPGVTPLLLNSIYAVASRISPDVRVRSDPASPDTAGDIFFERAERLLDESYDKPSISTVQSLLLLASHQHGAMRSARAWLYSGMAFRMAQDLGLHRNCDHWNIPPEERERRKRVFWCCYIVDRLGSAMYGRATTFEEKDCDVPFPSVDDHNLLSSDGEPVRLLDNFINLIKICDILGHVLKCIYYVRSLQNTEAKQADSVLTTLNKRLHQWYDQLPSSLRIKNDKSGKSPSVAVCQLHLIYYTTVILLHRPFIPGPDQSVSVPSLLPCASICASAADSILSITTYMLEHNQLKYVWNFAVYYIFSAGIIYIKDANDSNSDKLMEARMKVNKCMQALDEIESTWVTASKRCQIIAELTGLQDPNLGNDDRVNSISSWQPHELYSGRIGSTAVKSEEYDDRKSLYTTNNADFVNLPNPYQPQRINSTTMDPFAAPGIIPVDNNINNSKQYDTSSYWESSLDDWDQFQSSHHEAALVTSAPSVSHYQEKQHLIHTDQNVDVLSGVPLPWETTPSSAANNKTSGSFINYLQSNNENDRSSADGGPSNNSNNSTLKDLANAYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4R7</accession>
    <name>A0A367J4R7_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_009434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002234">
        <property type="protein sequence ID" value="RCH84913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4R7"/>
    <dbReference type="OrthoDB" id="2237965at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001337">
        <property type="entry name" value="TMV-like_coat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00721">
        <property type="entry name" value="TMV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCH84913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="114" mass="12877" checksum="F63BC3CEAFB61B68" modified="2018-11-07" version="1" fragment="single">FDCLLLAANVMVNVNRLDRKYPEYKTAGDTEYYCILSINELLRMIASPELGEVIKQSAFEQRYALEWYDDAEDAKSIGLGFSRLPGFSSNDDLTSKTKNGPSGELAHNDQKFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J4S3</accession>
    <name>A0A367J4S3_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_006558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002226">
        <property type="protein sequence ID" value="RCH84940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J4S3"/>
    <dbReference type="STRING" id="86630.A0A367J4S3"/>
    <dbReference type="OrthoDB" id="2288122at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="131" mass="15292" checksum="CD74AABFEF684097" modified="2018-11-07" version="1">MPIININDNPTTRIIPEYDDEVATIRFVNEAEFEEWFTKPFLGQPLASLLRLHTIKYQCDHSGKPKKRKESEVSIKKARTKESIKIGCLAYINRHLLTDGAVEVKYRWEHPDHNPCDVQEIISYRLPSEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J512</accession>
    <name>A0A367J512_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL28_5</name>
        <name evidence="7" type="ORF">CU097_005101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01002226">
        <property type="protein sequence ID" value="RCH84939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J512"/>
    <dbReference type="STRING" id="86630.A0A367J512"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCH84939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="145" mass="16333" checksum="33F013D4D9097FE8" modified="2018-11-07" version="1">MPTRLHHNRKKRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRHFHLKKNPLWRPVINLDKIWTLAGEGVREKYKNTEKVPVIDTLQHGYAKVLAKGTISQPVIVRTRYVSALAEKKIKEAGGVVELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J862</accession>
    <name>A0A367J862_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CU097_002051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001930">
        <property type="protein sequence ID" value="RCH86144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J862"/>
    <dbReference type="STRING" id="86630.A0A367J862"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="189"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="330"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="478"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="662"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="865"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCH86144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="1167" mass="133083" checksum="DFA4792D96A29DA1" modified="2018-11-07" version="1">MAVTAKRKQKKSSESEPPAKIAKKEAPVIKDEYIDESGSDDYDEDEEDEDYQLESTEIKKTAPTEDDIIAGELEGLKETVELFKSNIFKLEIEELLSEINMNYDKHKALEKALHNLKATFDSIPEGQPMKLVEFADNMLKKNKIVIPFPDPQPSPDALHSFAFKKPSSIHIVGGYALKTVAKTKMPFTVDVAVEMPSSIFQEKDYSNYRYFHKRACYLGVLAHAIQSSKKKFHIEYSTMNNDSRRPILLVKPGGDKSDVDFSKTKCVIRILPSVDLNTFPMHRLAPGKSSVKTSTDNTMATPHYNASLLVDTSYTANLAFLYQHSKACSEFKNAVLLARTWIYQRGLANIGFTPFLFAMIMSYLMQGNKDGIDKKLSSTHSSYQLFRGTLDFIASRDFKQNPVFIGESERQEFSKQEFLSHYDVVIVDPSGTLNLAASIHSSGLAQIQHETKLAMSLLNDPVDRFEPMFLKKVNDTKLRYDNVVRIKLPVPSTEVFTEHVKADYYSYLPFFVQRISHILTRGLTNRVDLIAVQHTYHHPHTWSVDANMPTDMDQDAAITIGLLLNSDNAPRLVDQGPQSQNEEEVAEFRKFWGNKSELRRFKDGSIVEAVVWQTQGYENRSLIVQQIVQYLLELHLSLKPEEIQYWADQFYSYLNYAKCLPQHMFNPELKITGFHSVMTAFTQLSKQIREIDDALPLMVSSVYPASSSLRYTTATLPHPVDFSNAIGYPNTTRFYEAIDVIVQIERSAKFPDDLSALQKVKHSFYLKMGEELKNRYQVDTVVVDDICERNPMAIRGYLDVYYQGFVFRCHIGLEQEPQQLKKIIDTKLSTPLQKSMAKEALEKYNYNITYQQSHTFSVQALCARFTAYSSTVRLVKRWFASHMLSPHVTDEMIELITAYVFLEPHPWTSPVSTFSGFLRVLNLLAGWDWQNTPLIVDIEGELTSKQRDEIISQFNHHRTTNPQMTRGVMTIATAKDTSGHRWTRTKPCRAVALRICALAKASLKVLDNVVEQDKPEDIKRVFITPMSDYSVVLQLDKSKCTRYYQSLNPEPKYFKSTGYSLLGDRIFAGFDPVSELIKEIEHIYGQTVMVFHDKYGGDKLAIVWNPLAAEPIQWKVSAGFNSVPVDMKKNGFLKIPKGQDEVSKLIAPNFDAILEEIKRIAGNLLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8C0</accession>
    <name>A0A367J8C0_RHIAZ</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CU097_009809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001927">
        <property type="protein sequence ID" value="RCH86160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8C0"/>
    <dbReference type="OrthoDB" id="2255243at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCH86160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="124" mass="14599" checksum="238950A31B8424F9" modified="2018-11-07" version="1">MPKKATYKQRSMVQDFSGLYMNGTRSWEDKQQATLDKLTHPEWGVMKEEEFRPLTHKHQNDLEDLHRNGQFIQDFYFWQANLGGYCMADMVQKVLVSSEGAFPLVRRIVDGAPHPGRRRRKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J8Y1</accession>
    <name>A0A367J8Y1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PNO1</name>
        <name evidence="11" type="ORF">CU097_009619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001879">
        <property type="protein sequence ID" value="RCH86387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J8Y1"/>
    <dbReference type="STRING" id="86630.A0A367J8Y1"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCH86387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="248" mass="27531" checksum="223A42217B21E214" modified="2018-11-07" version="1">MASLESFKAPTLVSKKTQKEIQKDDDEDDVLIDANAVPSSTSADADMEDAEDKPNFAPASAVEEKKVTKGSRKIPIPPHRMSPLKRHWLEIYSPLVEHMKLQVRMNVKTKSVELKTSNLTEDDGALQKGADFVKAFALGFEVEDAMALLRLDDIYLDTFEIKDVKTLHGDHLSRAIGRIAGRDGKTKFTIENASKTRIVLADTKIHILGSFQNIKIARDAVVSLILGSPPGKVYATLRTISARMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367J9J1</accession>
    <name>A0A367J9J1_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCDC43 PWI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CU097_001222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001872">
        <property type="protein sequence ID" value="RCH86411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367J9J1"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000252139">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="4">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCH86411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000252139"/>
        </source>
    </evidence>
    <sequence length="295" mass="35032" checksum="55CD49D59E6DCCCD" modified="2018-11-07" version="1" fragment="single">PQKLKFKTYINKQKGTQEIVKRLFDNSKKYGTLSTVGAKNQNPNKSKHVPLSPTDLPSSSQRKRIIAFGNGSFCSSVKDDDISEYIAGIIQDDSMEDDEKREVITGFLAEATEKSTENLIDTLLDEWKNLIKKREKEEEEKRSKLLEEAKVREEERRRKVEQEKQERETQRTLQKQLTKEEKEARELLMREYGYISEEEGEKDKEKKKEDGDNQQKERRKGKGSHHQNSSIIDPLLVENRNAEMIKEKERIRREQMKQAHEKERERNRQNLEKQKKEKTLDKEKKKTQKGERRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367JAZ3</accession>
    <name>A0A367JAZ3_RHIAZ</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit epsilon, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CU097_010740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rhizopus azygosporus</name>
        <name type="synonym">Rhizopus microsporus var. azygosporus</name>
        <dbReference type="NCBI Taxonomy" id="86630"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Fungi incertae sedis</taxon>
            <taxon>Mucoromycota</taxon>
            <taxon>Mucoromycotina</taxon>
            <taxon>Mucoromycetes</taxon>
            <taxon>Mucorales</taxon>
            <taxon>Mucorineae</taxon>
            <taxon>Rhizopodaceae</taxon>
            <taxon>Rhizopus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="G3 (Bethesda)" volume="8" first="2007" last="2018">
            <title>Phylogenetic and Phylogenomic Definition of Rhizopus Species.</title>
            <authorList>
                <person name="Gryganskyi A.P."/>
                <person name="Golan J."/>
                <person name="Dolatabadi S."/>
                <person name="Mondo S."/>
                <person name="Robb S."/>
                <person name="Idnurm A."/>
                <person name="Muszewska A."/>
                <person name="Steczkiewicz K."/>
                <person name="Masonjones S."/>
                <person name="Liao H.L."/>
                <person name="Gajdeczka M.T."/>
                <person name="Anike F."/>
                <person name="Vuek A."/>
                <person name="Anishchenko I.M."/>
                <person name="Voigt K."/>
                <person name="de Hoog G.S."/>
                <person name="Smith M.E."/>
                <person name="Heitman J."/>
                <person name="Vilgalys R."/>
                <person name="Stajich J.E."/>
            </authorList>
            <dbReference type="PubMed" id="29674435"/>
            <dbReference type="DOI" id="10.1534/g3.118.200235"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 357.93</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PJQL01001723">
        <property type="protein sequence ID" value="RCH87122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367JAZ3"/>
    <dbReference type="STRING" id="86630.A0A367JAZ3"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" 
[file cut: first 33554432 bytes kept]
[document cut: first 30726907 of 33554432 characters kept]
